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adrenal insufficiency guidelines

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https://www.readbyqxmd.com/read/27798546/evaluation-of-early-corticosteroid-therapy-in-management-of-pediatric-septic-shock-in-pediatric-intensive-care-patients-a-randomized-clinical-study
#1
Ahmed El-Nawawy, Doaa Khater, Heba Omar, Yasser Wali
BACKGROUND: Septic shock is a major healthcare problem. Adrenal insufficiency in children with septic shock is a recognized complication, yet is controversial regarding its management and effect on mortality. According to the current guidelines, children with risk factors for adrenal insufficiency should receive a stress dose of steroids in step 3 of treatment. This study aimed to evaluate and compare early corticosteroid therapy with the traditional use of steroids among pediatric septic shock patients...
October 25, 2016: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/27635959/congress-of-neurological-surgeons-systematic-review-and-evidence-based-guideline-for-pretreatment-endocrine-evaluation-of-patients-with-nonfunctioning-pituitary-adenomas
#2
Maria Fleseriu, Mary E Bodach, Luis M Tumialan, Vivien Bonert, Nelson M Oyesiku, Chirag G Patil, Zachary Litvack, Manish K Aghi, Gabriel Zada
BACKGROUND: Nonfunctioning pituitary adenomas (NFPAs) are among the most common pituitary lesions and may present with hypopituitarism and/or hyperprolactinemia. OBJECTIVE: To review the existing literature as it pertains to preoperative endocrine assessment in the workup for NFPAs. METHODS: A systematic review methodology was utilized to identify and screen articles assessing the role and results of preoperative laboratory assessment in patients with NFPAs...
October 2016: Neurosurgery
https://www.readbyqxmd.com/read/27598428/challenges-in-the-acute-management-of-profound-hyponatremia-presenting-with-severe-symptoms
#3
Yaasir Mamoojee, Rasha Mukhtar
Currently available guidelines in the acute management of severely symptomatic hypotonic hyponatremia vary in their approach to the use of hypertonic saline. In the acute setting, deciding on when to implement available treatment algorithm using hypertonic saline may be difficult, given that the duration of hyponatremia and potential alternative diagnoses presenting with similar symptoms may be hard to establish promptly. We present the case of a young female with symptomatic profound hyponatremia who subsequently developed osmotic demyelination syndrome due to rapid overcorrection of serum sodium concentration...
October 2016: Hospital Practice (Minneapolis)
https://www.readbyqxmd.com/read/27350721/diagnosis-and-treatment-of-adrenal-insufficiency-including-adrenal-crisis-a-japan-endocrine-society-clinical-practice-guideline-opinion
#4
Toshihiko Yanase, Toshihiro Tajima, Takuyuki Katabami, Yasumasa Iwasaki, Yusuke Tanahashi, Akira Sugawara, Tomonobu Hasegawa, Tomoatsu Mune, Yutaka Oki, Yuichi Nakagawa, Nobuhiro Miyamura, Chikara Shimizu, Michio Otsuki, Masatoshi Nomura, Yuko Akehi, Makito Tanabe, Soji Kasayama
This clinical practice guideline of the diagnosis and treatment of adrenal insufficiency (AI) including adrenal crisis was produced on behalf of the Japan Endocrine Society. This evidence-based guideline was developed by a committee including all authors, and was reviewed by a subcommittee of the Japan Endocrine Society. The Japanese version has already been published, and the essential points have been summarized in this English language version. We recommend diagnostic tests, including measurement of basal cortisol and ACTH levels in combination with a rapid ACTH (250 μg corticotropin) test, the CRH test, and for particular situations the insulin tolerance test...
June 24, 2016: Endocrine Journal
https://www.readbyqxmd.com/read/27063934/self-management-support-in-patients-with-adrenal-insufficiency
#5
Nick T M van der Meij, Rachel S van Leeuwaarde, Sigrid C J M Vervoort, Pierre M J Zelissen
OBJECTIVE: Patient education is an important intervention to prevent an adrenal crisis in patients with adrenal insufficiency. The objective of this study was to assess the knowledge of adjusting the dose of glucocorticoids in special circumstances in patients with adrenal insufficiency who had previously been educated on this topic. In patients with insufficient knowledge, we tried to identify the underlying causes and care needs. DESIGN: Quantitative and qualitative study...
October 2016: Clinical Endocrinology
https://www.readbyqxmd.com/read/26995200/a-comparison-of-salivary-steroid-levels-during-diagnostic-tests-for-adrenal-insufficiency
#6
Michaela Dušková, Kateřina Šimůnková, Jana Vítků, Lucie Sosvorová, Hana Jandíková, Hana Pospíšilová, Monika Šrámková, Mikuláš Kosák, Michal Kršek, Václav Hána, Magdaléna Žánová, Drahomíra Springer, Luboslav Stárka
Numerous diagnostic tests are used to evaluate the hypothalamic-pituitary-adrenal axis (HPA axis). The gold standard is still considered the insulin tolerance test (ITT), but this test has many limitations. Current guidelines therefore recommend the Synacthen test first when an HPA axis insufficiency is suspected. However, the dose of Synacthen that is diagnostically most accurate and sensitive is still a matter of debate. We investigated 15 healthy men with mean/median age 27.4/26 (SD±4.8) years, and mean/median BMI (body mass index) 25...
2016: Prague Medical Report
https://www.readbyqxmd.com/read/26844622/doping-status-of-dhea-treatment-for-female-athletes-with-adrenal-insufficiency
#7
David J Handelsman, Alvin M Matsumoto, David F Gerrard
OBJECTIVE: To review the doping status of dehydroepiandrosterone (DHEA) for female athletes with adrenal insufficiency within the framework of Therapeutic Use Exemption (TUE) applications for this proandrogen, which is included on the World Anti-Doping Agency (WADA)'s Prohibited List. DATA SOURCES AND MAIN RESULTS: Current knowledge of adrenal pathophysiology with a focus on the physiological role and pharmacological effects of DHEA in female athletes including placebo-controlled clinical trials of DHEA and consensus clinical practice and prescribing guidelines...
February 2, 2016: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
https://www.readbyqxmd.com/read/26807295/standards-of-ultrasound-imaging-of-the-adrenal-glands
#8
REVIEW
Rafał Z Słapa, Wiesław S Jakubowski, Katarzyna Dobruch-Sobczak, Anna A Kasperlik-Załuska
Adrenal glands are paired endocrine glands located over the upper renal poles. Adrenal pathologies have various clinical presentations. They can coexist with the hyperfunction of individual cortical zones or the medulla, insufficiency of the adrenal cortex or retained normal hormonal function. The most common adrenal masses are tumors incidentally detected in imaging examinations (ultrasound, tomography, magnetic resonance imaging), referred to as incidentalomas. They include a range of histopathological entities but cortical adenomas without hormonal hyperfunction are the most common...
December 2015: Journal of Ultrasonography
https://www.readbyqxmd.com/read/26760044/diagnosis-and-treatment-of-primary-adrenal-insufficiency-an-endocrine-society-clinical-practice-guideline
#9
REVIEW
Stefan R Bornstein, Bruno Allolio, Wiebke Arlt, Andreas Barthel, Andrew Don-Wauchope, Gary D Hammer, Eystein S Husebye, Deborah P Merke, M Hassan Murad, Constantine A Stratakis, David J Torpy
OBJECTIVE: This clinical practice guideline addresses the diagnosis and treatment of primary adrenal insufficiency. PARTICIPANTS: The Task Force included a chair, selected by The Clinical Guidelines Subcommittee of the Endocrine Society, eight additional clinicians experienced with the disease, a methodologist, and a medical writer. The co-sponsoring associations (European Society of Endocrinology and the American Association for Clinical Chemistry) had participating members...
February 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/26696958/adrenal-function-testing-following-hormone-therapy-for-infantile-spasms-case-series-and-review-of-literature
#10
John R Mytinger, Sasigarn A Bowden
Prednisolone and adrenocorticotropic hormone (ACTH) are "hormone" therapies for infantile spasms. There is limited data on the occurrence of decreased adrenal reserve or signs of clinical adrenal insufficiency after hormone therapy. This is a retrospective medical record review of patients referred to our Infantile Spasms Program. Our standardized infantile spasms management guideline began in September 2012 and initially included a post-hormone laboratory assessment of adrenal function. Medical records were assessed for hormone treatments, adrenal function testing, and signs of adrenal insufficiency...
2015: Frontiers in Neurology
https://www.readbyqxmd.com/read/26414641/a-survey-of-attitudes-and-practices-regarding-the-use-of-steroid-supplementation-in-pediatric-sepsis
#11
Amanda Carmean, James D Fortenberry, Courtney McCracken, Kiran B Hebbar
OBJECTIVE: Although corticosteroid (CS) supplementation for pediatric septic shock (PSS) is recommended by American College of Critical Care Medicine sepsis guidelines, most data are based on adult trials. Standardized protocols for stimulation testing for adrenal insufficiency (AI) and CS treatment in children have been reported, but the current state of CS use and protocols have not been evaluated in pediatric intensive care units in the United States. We surveyed a group of pediatric intensivists to assess current approaches...
October 2015: Pediatric Emergency Care
https://www.readbyqxmd.com/read/26339484/congenital-adrenal-hyperplasia
#12
REVIEW
Phyllis W Speiser
Congenital adrenal hyperplasia associated with deficiency of steroid 21-hydroxylase is the most common inborn error in adrenal function and the most common cause of adrenal insufficiency in the pediatric age group. As patients now survive into adulthood, adult health-care providers must also be familiar with this condition. Over the past several years, F1000 has published numerous commentaries updating research and practical guidelines for this condition. The purposes of this review are to summarize basic information defining congenital adrenal hyperplasia and to highlight current knowledge and controversies in management...
2015: F1000Research
https://www.readbyqxmd.com/read/26327341/-glucocorticoid-treatment-may-need-to-be-adjusted-during-operations-hospital-guidelines-reduces-the-risk-of-adrenal-insufficiency
#13
REVIEW
Sandra Jonmarker, Daniel Smole, Jan Calissendorff
In Sweden 200 000 patients annually receive corticosteroid treatment for inflammatory and immunological diseases. Corticosteroid treatment has adverse effects that are common and serious, but lack of corticosteroids can be life threatening. Supplemental perioperative corticosteroid treatment, stress dose, was prompted by two case reports in the 1950s describing patients on corticosteroid treatment that died after surgery. A review of studies identified 328 surgical patients on corticosteroid treatment who did not receive a stress dose...
2015: Läkartidningen
https://www.readbyqxmd.com/read/26282194/hypothalamic-pituitary-adrenal-hpa-axis-suppression-after-treatment-with-glucocorticoid-therapy-for-childhood-acute-lymphoblastic-leukaemia
#14
REVIEW
Maartje S Gordijn, Niki Rensen, Reinoud J B J Gemke, Elvira C van Dalen, Joost Rotteveel, Gertjan J L Kaspers
BACKGROUND: Glucocorticoids play a major role in the treatment of acute lymphoblastic leukaemia (ALL). However, supraphysiological doses can suppress the hypothalamic-pituitary-adrenal (HPA) axis. HPA axis suppression resulting in reduced cortisol response may cause an impaired stress response and an inadequate host defence against infections, which remains a cause of morbidity and death. Suppression commonly occurs in the first days after cessation of glucocorticoid therapy, but the exact duration is unclear...
2015: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/26197430/intermittent-inhaled-corticosteroid-therapy-versus-placebo-for-persistent-asthma-in-children-and-adults
#15
REVIEW
Jimmy Chong, Cheyaanthan Haran, Bhupendrasinh F Chauhan, Innes Asher
BACKGROUND: International guidelines advocate using daily inhaled corticosteroids (ICS) in the management of children and adults with persistent asthma. However, in real world clinical settings, these medicines are often used at irregular intervals by patients. Recent evidence suggests that the use of intermittent ICS, with treatment initiated at the time of early symptoms, may still have benefits for reducing the severity of an asthma exacerbation. OBJECTIVES: To compare the efficacy and safety of intermittent ICS versus placebo in the management of children and adults diagnosed with, or suspected to have, symptoms of mild persistent asthma...
2015: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/26108083/stepping-down-inhaled-corticosteroids-from-scheduled-to-as-needed-in-stable-asthma-systematic-review-and-meta-analysis
#16
REVIEW
Michael R Gionfriddo, John B Hagan, Christina R Hagan, Gerald W Volcheck, Ana Castaneda-Guarderas, Matthew A Rank
BACKGROUND: Many patients with asthma are potentially overtreated, which results in unnecessary cost and unnecessary exposure to drugs that may result in adverse events. Step down helps reduce overtreatment, may mitigate these harms, and is advocated by major guidelines. Unfortunately, data that support step down are sparse. OBJECTIVES: This systematic review aimed to examine the effect of stepping down from scheduled inhaled corticosteroids (ICS) to as-needed ICS in patients with stable asthma...
July 2015: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/26039319/vitamin-b6-intoxication-after-inappropriate-supplementation-with-micronutrients-following-bariatric-surgery
#17
N Cupa, D M Schulte, M Ahrens, S Schreiber, M Laudes
A 50-year-old Caucasian woman was admitted to our hospital with intermittent diarrhoea, emesis and increasingly brown-coloured skin, mainly the in light-exposed areas, after biliopancreatic diversion for obesity treatment. Differential diagnoses such as adrenal insufficiency were ruled out, but biochemical analysis demonstrated unusual high pyridoxine serum levels (vitamin B6). History revealed the intake of 300 mg of vitamin B6 per day over 6 months as described by her general practitioner. All symptoms disappeared after the discontinuation of vitamin B6 supplementation...
July 2015: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/26021762/radiographic-characteristics-of-adrenal-masses-preceding-the-diagnosis-of-adrenocortical-cancer
#18
T M Nogueira, R Lirov, E M Caoili, A M Lerario, B S Miller, M C B V Fragoso, N R Dunnick, G D Hammer, T Else
Incidentally discovered adrenal masses are common and the clinical evaluation and surveillance aims to diagnose hormone excess and malignancy. Adrenocortical cancer (ACC) is a very rare malignancy. This study aims to define the imaging characteristics of adrenal tumors preceding the diagnosis of ACC. Patients with prior (>5 months) adrenal tumors (<6 cm) subsequently diagnosed with ACC were identified in a large registry at a tertiary referral center. Retrospective chart and image review for patient characteristics and initial, interval, and diagnostic imaging characteristics (size, homogeneity, borders, density, growth rate, etc...
August 2015: Hormones & Cancer
https://www.readbyqxmd.com/read/25927108/evidence-for-exercise-training-in-the-management-of-hypertension-in-adults
#19
REVIEW
Alexandra S Ghadieh, Basem Saab
UNLABELLED: OBJECTIVE To provide recommendations on exercise training as part of the management of hypertension in adults.Quality of evidence Evidence was found through a systematic search of PubMed, MEDLINE, EMBASE, Agency for Healthcare Research and Quality evidence-based reports, Bandolier, Clinical Evidence, the Institute for Clinical Systems Improvement guidelines, the National Guideline Clearinghouse database, UpToDate,and the Cochrane Database of Systematic Reviews (part of Ovid Evidence Based Medicine Reviews) for articles published from January 1973 to September 2013...
March 2015: Canadian Family Physician Médecin de Famille Canadien
https://www.readbyqxmd.com/read/25743967/-medications-for-respiratory-insufficiency-and-exacerbations
#20
Martin Bischoff
No abstract text is available yet for this article.
March 5, 2015: MMW Fortschritte der Medizin
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