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Addison's disease guidelines

J Daniels, J M Turner-Cobb
Consideration of psychological distress in long-term endocrine conditions is of vital importance given the prevalence of anxiety and depression in such disorders. Poor mental health can lead to compromised self-care, higher utilization of health services, lower rates of adherence, reduced quality of life and ultimately poorer outcomes. Adjuvant psychological therapy offers an effective resource to reduce distress in endocrine conditions. While the vast majority of work in this area has focused on psychological screening and intervention in diabetes, identification and recognition of psychological distress are equally important in other endocrinological conditions, with supportive evidence in polycystic ovary syndrome and Addison's disease...
June 2017: Clinical Endocrinology
Ravi V Shah, Aferdita Spahillari, Stanford Mwasongwe, J Jeffrey Carr, James G Terry, Robert J Mentz, Daniel Addison, Udo Hoffmann, Jared Reis, Jane E Freedman, Joao A C Lima, Adolfo Correa, Venkatesh L Murthy
Importance: Modern prevention guidelines substantially increase the number of individuals who are eligible for treatment with statins. Efforts to refine statin eligibility via coronary calcification have been studied in white populations but not, to our knowledge, in large African American populations. Objective: To compare the relative accuracy of US Preventive Services Task Force (USPSTF) and American College of Cardiology/American Heart Association (ACC/AHA) recommendations in identifying African American individuals with subclinical and clinical atherosclerotic cardiovascular disease (ASCVD)...
June 1, 2017: JAMA Cardiology
Ravi S Hira, Jennifer B Cowart, Julia M Akeroyd, David J Ramsey, Yashashwi Pokharel, Vijay Nambi, Hani Jneid, Anita Deswal, Ali Denktas, Addison Taylor, Khurram Nasir, Christie M Ballantyne, Laura A Petersen, Salim S Virani
Cardiovascular disease (CVD) is a systemic process involving multiple vascular beds and includes coronary heart disease (CHD), ischemic cerebrovascular disease (ICVD), and peripheral arterial disease (PAD). All these manifestations are associated with an increased risk of subsequent myocardial infarction, stroke, and death. Guideline-directed medical therapy is recommended for all patients with CVD. In a cohort of US veterans, we identified 1,242,015 patients with CVD receiving care in 130 Veterans Affairs facilities from October 1, 2013 to September 30, 2014...
October 15, 2016: American Journal of Cardiology
Jan-Christoph Galle, Janet Addison, Michael G Suranyi, Kathleen Claes, Salvatore Di Giulio, Alain Guerin, Hans Herlitz, István Kiss, Mourad Farouk, Nick Manamley, Gerhard Wirnsberger, Christopher Winearls
BACKGROUND: Extended dosing of the erythropoiesis-stimulating agent (ESA) darbepoetin alfa (DA) once biweekly or monthly reduces anaemia treatment burden. This observational study assessed outcomes and dosing patterns in patients with chronic kidney disease not on dialysis (CKD-NoD) commencing extended dosing of DA. METHODS: Adult CKD-NoD patients starting extended dosing of DA in Europe or Australia in June 2006 or later were followed up until December 2012. Outcomes included haemoglobin (Hb) concentration, ESA dosing, mortality rates and receipt of dialysis and renal transplantation...
December 2016: Nephrology, Dialysis, Transplantation
Brian Hutton, Christina Addison, Sasha Mazzarello, Anil A Joy, Nathaniel Bouganim, Dean Fergusson, Mark Clemons
OBJECTIVE: Questions remain regarding the optimal use of bone-targeted agents in patients with metastatic bone disease. The purpose of this study was to assess current clinical practice regarding the use and administration of bone-targeted agents by Canadian oncologists in patients with metastatic breast and prostate cancer. METHODS: A survey was designed to explore; bone-targeted agent use in metastatic bone disease, variability in the choice and the frequency of administration of these agents...
June 2013: Journal of Bone Oncology
Vu Hoang, Mahboob Alam, Daniel Addison, Francisco Macedo, Salim Virani, Yochai Birnbaum
PURPOSE: Current practice guidelines support the use of angiotensin-converting enzyme inhibitors (ACEi) and angiotensin-receptor blockers (ARBs) in patients with coronary artery disease (CAD) without heart failure (HF). However, a number of cited trials were performed prior to the era of prevalent statin use. Our objective was to evaluate the effectiveness of ACEi and ARBs in reducing cardiovascular events as well as the impact of statin therapy. METHODS: We searched the MEDLINE and EMBASE databases for randomized-controlled trials (1/1/1980 - 8/31/2015) with ACEi or ARBs as the single intervention for patients with CAD without HF...
April 2016: Cardiovascular Drugs and Therapy
Mark Jean Just, Mariusz Kozakiewicz
BACKGROUND: Anemia is a disease that can co-exist with depression, other mental disorders, or somatic diseases. Anemia can imitate symptoms of depression, while depression symptoms can mask concurring symptoms of anemia. CASE PRESENTATION: I am presenting a case of a 48-year-old woman with Addison-Biermer anemia, with co-existing mood disorders. The clinical analysis of the presented patient's history indicates diagnostic problems and a need for a detailed analysis of drug-related complications that occurred during previous treatment, eg, in the form of neuroleptic malignant syndrome...
2015: Neuropsychiatric Disease and Treatment
Eugene Mutimura, Diane Addison, Kathryn Anastos, Donald Hoover, Jean Claude Dusingize, Ben Karenzie, Isabelle Izimukwiye, Leo Mutesa, Sabin Nsanzimana, Denis Nash
BACKGROUND: Initiation of antiretroviral therapy (ART) in the advanced stages of HIV infection remains a major challenge in sub-Saharan Africa. This study was conducted to better understand barriers and enablers to timely ART initiation in Rwanda where ART coverage is high and national ART eligibility guidelines first expanded in 2007-2008. METHODS: Using data on 6326 patients (≥15 years) at five Rwandan clinics, we assessed trends and correlates of CD4 cell count at ART initiation and the proportion initiating ART with advanced HIV disease (CD4 <200 cells/μl or WHO stage IV)...
January 2, 2015: AIDS
Appiah-Korang Labi, Noah Obeng-Nkrumah, Naa Okaikor Addison, Eric S Donkor, Eric Sampene Donkor
BACKGROUND: Despite the clinical significance of Salmonella infections, surveillance data worldwide remains limited and is more so exemplified by the lack of reports from Africa especially in eastern, central and western Africa. This study reports on Salmonella serotypes as significant causes of blood stream infections (BSI) and multidrug antibiotic resistance at Korle-Bu Teaching Hospital in Accra, Ghana. METHODS: Antibiogram patterns, seasonal variations in disease incidence and predisposing factors for infection with Salmonella serotypes were analyzed retrospectively over a 4-year period from January 2010 to December 2013...
2014: BMC Infectious Diseases
Massimo Sartelli, Mark A Malangoni, Addison K May, Pierluigi Viale, Lillian S Kao, Fausto Catena, Luca Ansaloni, Ernest E Moore, Fred A Moore, Andrew B Peitzman, Raul Coimbra, Ari Leppaniemi, Yoram Kluger, Walter Biffl, Kaoru Koike, Massimo Girardis, Carlos A Ordonez, Mario Tavola, Miguel Cainzos, Salomone Di Saverio, Gustavo P Fraga, Igor Gerych, Michael D Kelly, Korhan Taviloglu, Imtiaz Wani, Sanjay Marwah, Miklosh Bala, Wagih Ghnnam, Nissar Shaikh, Osvaldo Chiara, Mario Paulo Faro, Gerson Alves Pereira, Carlos Augusto Gomes, Federico Coccolini, Cristian Tranà, Davide Corbella, Pietro Brambillasca, Yunfeng Cui, Helmut A Segovia Lohse, Vladimir Khokha, Kenneth Yy Kok, Suk-Kyung Hong, Kuo-Ching Yuan
Skin and soft tissue infections (SSTIs) encompass a variety of pathological conditions ranging from simple superficial infections to severe necrotizing soft tissue infections. Necrotizing soft tissue infections (NSTIs) are potentially life-threatening infections of any layer of the soft tissue compartment associated with widespread necrosis and systemic toxicity. Successful management of NSTIs involves prompt recognition, timely surgical debridement or drainage, resuscitation and appropriate antibiotic therapy...
2014: World Journal of Emergency Surgery: WJES
Eugene Mutimura, Diane Addison, Kathryn Anastos, Donald Hoover, Jean Claude Dusingize, Ben Karenzi, Isabelle Izimukwiye, Leo Mutesa, Sabin Nsanzimana, Denis Nash
BACKGROUND: Initiation of antiretroviral therapy (ART) in the advanced stages of HIV infection remains a major challenge in sub-Saharan Africa. This study was conducted to better understand barriers and enablers to timely ART initiation in Rwanda where ART coverage is high and national ART eligibility guidelines first expanded in 2007-2008. METHODS: Using data on 6326 patients (≥15 years) at five Rwandan clinics, we assessed trends and determinants of CD4 cell count at ART initiation and the proportion initiating ART with advanced HIV disease (CD4 <200 cells/μl or WHO stage IV)...
November 13, 2014: AIDS
Nicolas Kluger, Niina Matikainen, Harri Sintonen, Annamari Ranki, Risto P Roine, Camilla Schalin-Jäntti
OBJECTIVE: Patients with Addison's disease (AD) on conventional replacement therapy have impaired health-related quality of life (HRQoL). It is possible that lower hydrocortisone (HC) doses recommended by current guidelines could restore HRQoL. We compared HRQoL in AD patients treated according to current HC recommendations to that of the age- and gender-standardized general population. SUBJECTS, DESIGN AND MEASUREMENT: We assessed HRQoL in a cross-sectional setting with the 15D instrument in a Finnish AD cohort (n = 107) and compared the results with those of a large sample of general population (n = 5671)...
October 2014: Clinical Endocrinology
John Kells, Charles M Dollbaum
Saliva is an excellent medium for the measurement of the biologically active fraction of steroid hormones in the bloodstream because it is a natural ultrafiltrate of blood, and steroids not bound by carrier proteins in the blood freely diffuse into saliva. The baseline measurement of hormone levels in saliva provides an accurate assessment and can be used to identify or monitor a number of clinical conditions, including climacteric changes in perimenopausal or postmenopausal women, adrenal disorders such as Addison's disease or Cushing's disease, and androgen deficiency in men and women, the age-related decrease of hormones such as testosterone and dehydroepiandrosterone can also be assessed and monitored...
July 2009: International Journal of Pharmaceutical Compounding
John A H Wass, Wiebke Arlt
No abstract text is available yet for this article.
October 9, 2012: BMJ: British Medical Journal
Bertil Ekman, Margareta Bachrach-Lindström, Torbjörn Lindström, Jeanette Wahlberg, Johan Blomgren, Hans J Arnqvist
CONTEXT: Current guidelines on how to divide the daily cortisol substitution dose in patients with primary adrenal insufficiency (PAI) are controversial and mainly based on empirical data. OBJECTIVE: To assess how an equal dose of hydrocortisone (HC) given either four times daily or twice daily influence diurnal profiles of cortisol and ACTH, patient preferences and health-related quality of life (HRQoL). DESIGN: Double blind, crossover. METHODS: Fifteen patients with PAI (six women) were included...
July 2012: Clinical Endocrinology
Odessa Addison, Paul C LaStayo, Leland E Dibble, Robin L Marcus
BACKGROUND: Physical therapists treat older individuals, characterized as both a needy and expanding population. Frailty, a predisability condition with links to chronic inflammatory conditions, is estimated to affect 7% of individuals older than 60 years and 40% of people older than 80 years. Chronic inflammation is one of the most important physiologic correlates of the frailty syndrome and high levels of proinflammatory cytokines, related to both aging and increasing adiposity in older individuals are related to an increased risk of mortality, sarcopenia, reduced muscle strength and decreased mobility...
April 2012: Journal of Geriatric Physical Therapy
Addison K May
BACKGROUND: The Surgical Infection Society Guidelines for the treatment of complicated skin and soft tissue infections (SSTIs) were published in October 2009 in Surgical Infections, and an overview of these guidelines was provided at the Thirtieth Annual Meeting of the Society. A summary of this overview is provided. METHODS: Review of relevant papers related to complicated SSTIs published between 1966 and 2008 with graded recommendations and summations of general epidemiology and recommendations...
June 2011: Surgical Infections
Lalantha Leelarathna, Louise Breen, James K Powrie, Stephen M Thomas, Rustom Guzder, Barbara McGowan, Paul V Carroll
There are no consensus guidelines on the optimum long-term care of patients with primary adrenal failure. Published data suggest increased morbidity and mortality in patients treated with current therapy. Investigations of bone mineral density (BMD) in adults with adrenal failure have reported conflicting results. The objectives of this study were to determine the prevalence of auto-immune and other co-morbidities, describe the treatment regimens and to assess the BMD of adults with auto-immune Addison's disease (AAD)...
August 2010: Endocrine
Joseph S Solomkin, John E Mazuski, John S Bradley, Keith A Rodvold, Ellie J C Goldstein, Ellen J Baron, Patrick J O'Neill, Anthony W Chow, E Patchen Dellinger, Soumitra R Eachempati, Sherwood Gorbach, Mary Hilfiker, Addison K May, Avery B Nathens, Robert G Sawyer, John G Bartlett
Evidence-based guidelines for managing patients with intra-abdominal infection were prepared by an Expert Panel of the Surgical Infection Society and the Infectious Diseases Society of America. These updated guidelines replace those previously published in 2002 and 2003. The guidelines are intended for treating patients who either have these infections or may be at risk for them. New information, based on publications from the period 2003-2008, is incorporated into this guideline document. The panel has also added recommendations for managing intra-abdominal infection in children, particularly where such management differs from that of adults; for appendicitis in patients of all ages; and for necrotizing enterocolitis in neonates...
February 2010: Surgical Infections
Kamaljit K Chatha, Jonathan G Middle, Eric S Kilpatrick
UNLABELLED: We present the first national audit of the Short Synacthen Test (SST), identifying the clinical, analytical and interpretative procedures adopted by 89 laboratories. BACKGROUND: The SST has replaced the insulin stress test as the first-line test to assess adrenal insufficiency and has received considerable attention regarding its sensitivity and specificity. Concerns regarding this test include the bias of cortisol methods, cut-off values used, contraindications and the limitations of the test in diagnosing recent, mild secondary adrenal insufficiency...
March 2010: Annals of Clinical Biochemistry
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