Cecilie U Rank, Benjamin O Wolthers, Kathrine Grell, Birgitte K Albertsen, Thomas L Frandsen, Ulrik M Overgaard, Nina Toft, Ove J Nielsen, Peder S Wehner, Arja Harila-Saari, Mats M Heyman, Johan Malmros, Jonas Abrahamsson, Ulrika Norén-Nyström, Beata Tomaszewska-Toporska, Bendik Lund, Kirsten B Jarvis, Petter Quist-Paulsen, Goda E Vaitkevičienė, Laimonas Griškevičius, Mervi Taskinen, Ulla Wartiovaara-Kautto, Kristi Lepik, Mari Punab, Ólafur G Jónsson, Kjeld Schmiegelow
PURPOSE: Asparaginase-associated pancreatitis (AAP) is common in patients with acute lymphoblastic leukemia (ALL), but risk differences across age groups both in relation to first-time AAP and after asparaginase re-exposure have not been explored. PATIENTS AND METHODS: We prospectively registered AAP (n = 168) during treatment of 2,448 consecutive ALL patients aged 1.0-45.9 years diagnosed from July 2008 to October 2018 and treated according to the Nordic Society of Pediatric Hematology and Oncology (NOPHO) ALL2008 protocol...
January 10, 2020: Journal of Clinical Oncology