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https://www.readbyqxmd.com/read/28527394/elucidation-of-penetration-enhancement-mechanism-of-emu-oil-using-ftir-microspectroscopy-at-emira-laboratory-of-sesame-synchrotron
#1
Randa S H Mansour, Alsayed A Sallam, Imad I Hamdan, Enam A Khalil, Ibraheem Yousef
It has been proposed that Emu oil possesses skin permeation-enhancing effect. This study aimed to address its possible penetration enhancement mechanism(s) using IR microscopy, in accordance with LPP theory. The penetration of Emu oil through the layers of human skin was accomplished by monitoring oil-IR characteristic feature at 3006cm(-1). The unsaturated components of Emu oil accumulated at about 270μm depth of skin surface. The interaction of Emu oil with lipid and protein constituents of SC was investigated in comparison with a commonly used enhancer, IPM...
May 12, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28526392/susceptibility-to-tobacco-product-use-among-youth-in-wave-1-of-the-population-assessment-of-tobacco-and-health-path-study
#2
Dennis R Trinidad, John P Pierce, James D Sargent, Martha M White, David R Strong, David B Portnoy, Victoria R Green, Cassandra A Stanton, Kelvin Choi, Maansi Bansal-Travers, Yuyan Shi, Jennifer Pearson, Annette R Kaufman, Nicolette Borek, Blair N Coleman, Andrew Hyland, Charles Carusi, Sheila Kealey, Eric Leas, Madison Noble, Karen Messer
The purpose of this study was to investigate susceptibility and ever use of tobacco products among adolescents and young adults in the US. Cross-sectional analysis of Wave 1(2013-2014) adolescent (12-17year-olds; n=13,651) and young adult (18-24year-olds; n=9112) data from the nationally-representative Population Assessment of Tobacco and Health (PATH) Study was conducted. At 12years, 5% were ever tobacco users and 36% were susceptible to use. Seventy percent were susceptible at age 17years, and the same proportion were ever users at age 22years...
May 16, 2017: Preventive Medicine
https://www.readbyqxmd.com/read/28525871/different-binding-mechanisms-of-neutral-and-anionic-poly-perfluorinated-chemicals-to-human-transthyretin-revealed-by-in-silico-models
#3
Xianhai Yang, Felichesmi Lyakurwa, Hongbin Xie, Jingwen Chen, Xuehua Li, Xianliang Qiao, Xiyun Cai
Chemical forms-dependent binding interactions between phenolic compounds and human transthyretin (hTTR) have been elaborated previously. However, it is not known whether the binding interactions between ionizable halogenated alphatic compounds and hTTR also have the same manner. In this study, poly-/perfluorinated chemicals (PFCs) were selected as model compounds and molecular dynamic simulation was performed to investigate the binding mechanisms between PFCs and hTTR. Results show the binding interactions between the halogenated aliphatic compounds and hTTR are related to the chemical forms...
May 5, 2017: Chemosphere
https://www.readbyqxmd.com/read/28525839/discovery-of-efficient-stimulators-for-adult-hippocampal-neurogenesis-based-on-scaffolds-in-dragon-s-blood
#4
Jian-Hua Liang, Liang Yang, Si Wu, Si-Si Liu, Mark Cushman, Jing Tian, Nuo-Min Li, Qing-Hu Yang, He-Ao Zhang, Yun-Jie Qiu, Lin Xiang, Cong-Xuan Ma, Xue-Meng Li, Hong Qing
Reduction of hippocampal neurogenesis caused by aging and neurological disorders would impair neural circuits and result in memory loss. A new lead compound (N-trans-3',4'-methylenedioxystilben-4-yl acetamide 27) has been discovered to efficiently stimulate adult rats' neurogenesis. In-depth structure-activity relationship studies proved the necessity of a stilbene scaffold that is absent in highly cytotoxic analogs such as chalcones and heteroaryl rings and inactive analogs such as diphenyl acetylene and diphenyl ethane, and validated the importance of an NH in the carboxamide and a methylenedioxy substituent on the benzene ring...
May 10, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28522767/individual-hemoglobin-mass-response-to-normobaric-and-hypobaric-live-high-train-low-a-one-year-crossover-study
#5
Anna Hauser, Severin Troesch, Jonas J Saugy, Laurent Schmitt, Roberto Cejuela-Anta, Raphael Faiss, Thomas Steiner, Neil Robinson, Grégoire P Millet, Jon Peter Wehrlin
PURPOSE: To compare individual hemoglobin mass (Hbmass) changes following a live high-train low (LHTL) altitude training camp under either normobaric hypoxia (NH) or hypobaric hypoxia (HH) conditions in endurance athletes. METHODS: In a crossover design with a one-year washout, 15 male triathletes randomly performed two 18-d LHTL training camps in either HH or NH. All athletes slept at 2250 m and trained at altitudes < 1200 m. Hbmass was measured in duplicate with the optimized carbon monoxide rebreathing method before (pre-) and immediately after (post-) each 18 d training camp...
May 18, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28521971/comparison-of-early-sequential-hypothermia-and-delayed-hypothermia-on-neurological-function-after-resuscitation-in-a-swine-model
#6
Wei Yuan, Jun-Yuan Wu, Yong-Zhen Zhao, Jie Li, Jie-Bin Li, Zhen-Hua Li, Chun-Sheng Li
BACKGROUND: We utilized a porcine cardiac arrest model to compare early sequential hypothermia (ESH) with delayed hypothermia (DH) and no hypothermia (NH) to investigate the different effects on cerebral function after resuscitation. METHODS: After return of spontaneous circulation (ROSC), resuscitated 24 pigs divided into three groups. The ESH group implemented early sequential hypothermia immediately, and the DH group implemented delayed hypothermia at 1 h after ROSC...
May 11, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28515796/genetic-heterogeneity-of-patients-with-suspected-silver-russell-syndrome-genome-wide-copy-number-analysis-in-82-patients-without-imprinting-defects
#7
Takanobu Inoue, Akie Nakamura, Tomoko Fuke, Kazuki Yamazawa, Shinichiro Sano, Keiko Matsubara, Seiji Mizuno, Yoshika Matsukura, Chie Harashima, Tatsuji Hasegawa, Hisakazu Nakajima, Kumi Tsumura, Zenro Kizaki, Akira Oka, Tsutomu Ogata, Maki Fukami, Masayo Kagami
BACKGROUND: Silver-Russell syndrome (SRS) is a rare congenital disorder characterized by pre- and postnatal growth failure and dysmorphic features. Recently, pathogenic copy number variations (PCNVs) and imprinting defects other than hypomethylation of the H19-differentially methylated region (DMR) and maternal uniparental disomy chromosome 7 have been reported in patients with the SRS phenotype. This study aimed to clarify the frequency and clinical features of patients with SRS phenotype caused by PCNVs...
2017: Clinical Epigenetics
https://www.readbyqxmd.com/read/28514507/hydrogen-bond-involving-cavity-nh-protons-drives-supramolecular-oligomerization-of-amido-corroles
#8
Daniel T Gryko, Rafał Orłowski, Mariusz Tasior, Barbara Ventura, Olga Staszewska-Krajewska, Wojciech Schilf, Michał Cyrański, Łukasz Dobrzycki
Trans-A2B-Corroles with amide substituents at different positions versus the macrocyclic core have been synthesized. Their self-organizing properties have been comprehensively evaluated both in solid-state and in solution. The rigid arrangement of the amide functionality with the corrole ring led to the formation of strong intramolecular interactions and precluded intermolecular interactions. Replacement of sterically hindered C6F5 substituents at positions 5 and 15 with smaller electron-withdrawing CO2Me groups resulted in significant changes in the self-assembly pattern...
May 17, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28509854/the-phenolic-fraction-of-mentha-haplocalyx-and-its-constituent-linarin-ameliorate-inflammatory-response-through-inactivation-of-nf-%C3%AE%C2%BAb-and-mapks-in-lipopolysaccharide-induced-raw264-7-cells
#9
Xiangyang Chen, Shujing Zhang, Zinan Xuan, Dongyu Ge, Xiaoming Chen, Junjie Zhang, Qian Wang, Ying Wu, Bin Liu
Mentha haplocalyx has been widely used for its flavoring and medicinal properties and as a traditional Chinese medicine with its anti-inflammation properties. The present study was designed to investigate the anti-inflammatory effects and potential molecular mechanisms of the phenolic fraction of M. haplocalyx (MHP) and its constituent linarin in lipopolysaccharide (LPS)-induced RAW264.7 cells. The high-performance liquid chromatography coupled with linear ion trap-orbitrap mass spectrometry (HPLC-LTQ-Orbitrap MS) was used to analyze the chemical composition of MHP...
May 16, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28508647/copper-promoted-desulfitative-n-arylation-of-sulfonamides-and-sulfoximines-with-sodium-arylsulfinates
#10
Yangji Jiang, Yaping You, Wanrong Dong, Zhihong Peng, Yingjun Zhang, Delie An
A general and direct N-arylation of sulfonamides and NH-sulfoximines by sodium arylsulfinates through a desulfitative pathway was herein demonstrated. The reaction proceeded with catalytic loadings of Cu(II)-catalysts without any external ligands. And the novel arylation protocol featured for high efficiency (up to 93% yields) and good substituent tolerance (up to 53 examples). Moreover, a plausible reaction mechanism was also discussed.
May 16, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28506828/stringency-of-bacterial-prolipoprotein-signal-peptidase-lspa-in-recognition-of-signal-peptides-structure-function-correlation
#11
Nikhil Sangith, Krishnan Sankaran
Bacterial lipid modification of proteins is an essential post-translational event committed by Phosphatidylglycerol: prolipoprotein diacylglyceryl transferase (Lgt) by catalysing diacyglyceryl transfer from Phosphatidylglycerol to cysteine present in the characteristic 'lipobox' ([LVI] ((-3)) [ASTVI] ((-2)) [GAS] ((-1)) C ((+1))) of prolipoprotein signal peptides. This is then followed by the cleavage of the signal peptide by lipoprotein-specific signal peptidase (LspA). It had been known for long that threonine at the -1 position allows diacylglyceryl modification by Lgt, but not signal peptide cleavage by LspA...
May 12, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28504894/preventing-burdensome-transitions-of-nursing-home-residents-with-advanced-dementia-it-s-more-than-advance-directives
#12
Ruth Palan Lopez, Susan L Mitchell, Jane L Givens
BACKGROUND: Although a palliative approach to care is recommended for people with advanced dementia, many nursing home (NH) residents with dementia experience burdensome interventions such as hospital transfers at the end of life. OBJECTIVE: The goal of this study was to examine how decisions to transfer NH residents with advanced dementia are made, from the perspective of NH nurses and physicians. METHODS: A qualitative, descriptive method was used...
May 15, 2017: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/28503675/costs-of-a-staff-communication-intervention-to-reduce-dementia-behaviors-in-nursing-home-care
#13
Kristine N Williams, Padmaja Ayyagari, Yelena Perkhounkova, Marjorie J Bott, Ruth Herman, Ann Bossen
CONTEXT: Persons with Alzheimer's disease and other dementias experience behavioral symptoms that frequently result in nursing home (NH) placement. Managing behavioral symptoms in the NH increases staff time required to complete care, and adds to staff stress and turnover, with estimated cost increases of 30%. The Changing Talk to Reduce Resistivenes to Dementia Care (CHAT) study found that an intervention that improved staff communication by reducing elderspeak led to reduced behavioral symptoms of dementia or resistiveness to care (RTC)...
2017: Journal of Nursing Home Research Sciences
https://www.readbyqxmd.com/read/28502085/pathogenicity-of-adar1-mutation-in-a-chinese-family-with-dyschromatosis-symmetrica-hereditaria
#14
S-D Zhang, S-J Feng, K Nh-Tseung, J-J Zhao
Dyschromatosis symmetrica hereditaria (DSH, OMIM 127400) is a rare pigmentary genodermatosis with an autosomal dominant mode of inheritance that is characterized by a mixture of hyperpigmented and hypopigmented macules on the dorsal regions of the extremities and freckle-like macules on the face. ADAR1 is the corresponding causal gene of DSH.(1) Here, we report a novel heterozygous mutation in the ADAR1 gene in a Chinese family with DSH that may potentially be responsible for the observed clinical presentations, which differ from those previously described...
May 14, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28498653/recovering-rare-earth-elements-from-aqueous-solution-with-porous-amine-epoxy-networks
#15
Walter Christopher Wilfong, Brian W Kail, Tracy L Bank, Bret H Howard, McMahan L Gray
Recovering aqueous rare earth elements (REEs) from domestic water sources is one key strategy to diminish the U.S.'s foreign reliance of these precious commodities. Herein, we synthesized an array of porous, amine-epoxy monolith and particle REE recovery sorbents from different polyamine, namely tetraethylenepentamine, and diepoxide (E2), triepoxide (E3), and tetra-epoxide (E4) monomer combinations via a polymer-induced phase separation (PIPS) method. The polyamines provided -NH2 (primary amine) plus -NH (secondary amine) REE adsorption sites, which were partially reacted with C-O-C (epoxide) groups at different amine/epoxide ratios to precipitate porous materials that exhibited a wide range of apparent porosities and REE recoveries/affinities...
May 19, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28497971/9-9-difluorobispidine-analogues-of-cisplatin-carboplatin-and-oxaliplatin
#16
Raja Mitra, Richard Goddard, Klaus-Richard Pörschke
As part of a comprehensive study of N-unsubstituted bispidines, the novel 9,9-difluorobispidine (D) has been synthesized. The compound crystallizes from pentane below 0 °C in the ordered-crystalline phase D-II and undergoes at 0-30 °C a stepwise endothermic phase transition to a dynamically disordered crystalline phase D-I; melting occurs at 227 °C. Single crystalline D-II has been subjected to X-ray structure analysis, revealing association of the molecules to form chains. Reaction of (1,5-hexadiene)PtCl2 with D affords {C7H10F2(NH)2}PtCl2 (D1), which can be converted by conventional routes to {C7H10F2(NH)2}Pt(cbdca)·5H2O (D2) and {C7H10F2(NH)2}Pt(C2O4) (D3)...
May 12, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28497214/comparative-theoretical-studies-of-differently-bridged-nitramino-substituted-ditetrazole-2-n-oxides-with-high-detonation-performance-and-an-oxygen-balance-of-around-zero
#17
Qiong Wu, Bo Kou, Zusheng Hang, Weihua Zhu
In this work, six (A-F) nitramino (-NHNO2)-substituted ditetrazole 2-N-oxides with different bridging groups (-CH2-, -CH2-CH2-, -NH-, -N=N-, and -NH-NH-) were designed. The six compounds were based on the parent compound tetrazole 2-N-oxide, which possesses a high oxygen balance and high density. The structure, heat of formation, density, detonation properties (detonation velocity D and detonation pressure P), and the sensitivity of each compound was investigated systematically via density functional theory, by studying the electrostatic potential, and using molecular mechanics...
June 2017: Journal of Molecular Modeling
https://www.readbyqxmd.com/read/28497135/unscrambling-micro-solvation-of-cooh-and-nh-groups-in-neat-dimethyl-sulfoxide-insights-from-1-h-nmr-spectroscopy-and-computational-studies
#18
Panteleimon G Takis, Konstantinos D Papavasileiou, Loukas D Peristeras, Georgios C Boulougouris, Vasilios S Melissas, Anastassios N Troganis
Dimethyl sulfoxide (DMSO) has a significant, multi-faceted role in medicine, pharmacy, and biology as well as in biophysical chemistry and catalysis. Its physical properties and impact on biomolecular structures still attract major scientific interest, especially the interactions of DMSO with biomolecular functional groups. In the present study, we shed light on the "isolated" carboxylic (-COOH) and amide (-NH) interactions in neat DMSO via(1)H NMR studies along with extensive theoretical approaches, i.e. molecular dynamics (MD) simulations, density functional theory (DFT), and ab initio calculations, applied on model compounds (i...
May 12, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28494395/conformational-and-vibrational-reassessment-of-solid-paracetamol
#19
Ana M Amado, Celeste Azevedo, Paulo J A Ribeiro-Claro
This work provides an answer to the urge for a more detailed and accurate knowledge of the vibrational spectrum of the widely used analgesic/antipyretic drug commonly known as paracetamol. A comprehensive spectroscopic analysis - including infrared, Raman, and inelastic neutron scattering (INS) - is combined with a computational approach which takes account for the effects of intermolecular interactions in the solid state. This allows a full reassessment of the vibrational assignments for Paracetamol, thus preventing the propagation of incorrect data analysis and misassignments already found in the literature...
April 27, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28493433/highly-active-and-iso-selective-catalysts-for-rop-of-cyclic-esters-using-group-2-metal-initiators
#20
Tarun Kanti Panda, Jayeeta Bhattacharjee, A Harinath, Hari P Nayek, Alok Sarkar
A series of alkali and alkaline earth (Ae) metal complexes bearing 1,2 phenylene(bis-diphenylphosphinothioic/selenoic amide) [{Ph2P(E)NH}2C6H4] (E = S (1-H2); Se (2-H2) ligands are reported. Alkali metal complexes [{Ph2P(S)N}2C6H4]Na(THF)4 (3a) [{Ph2P(Se)N}2C6H4]Na(THF)4 (3b), and [{Ph2P(Se)N}2C6H4]K(THF)5 (4b) were obtained in good yield by treating protic ligand 1-H2 or 2-H2 with corresponding metal hexamethyldisilazides [MN(SiMe3)2] (M = Na and K) at ambient temperature. The Ae metal complexes formulated as [{Ph2P(E)N}2C6H4]M(THF)3 [E = S, M = Ca (5a), Sr (6a), Ba (7a); E = Se, M = Ca (5b), Sr (6b), Ba (7b)] can be synthesized using two routes...
May 11, 2017: Chemistry: a European Journal
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