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Matthias Boentert, Christian Glatz, Cornelia Helmle, Angelika Okegwo, Peter Young
OBJECTIVE: This retrospective study aimed to investigate whether overnight oxymetry and early morning blood gas analysis predict nocturnal hypoventilation (NH) as reflected by night-time hypercapnia in patients with amyotrophic lateral sclerosis (ALS). In addition, prevalence and clinical determinants of sleep apnoea in ALS were evaluated. METHODS: In 250 patients with non-ventilated ALS, transcutaneous capnometry was performed along with polysomnography or polygraphy and early morning blood gases...
October 20, 2017: Journal of Neurology, Neurosurgery, and Psychiatry
Gigliola Lusvardi, Corrado Barani, Federica Giubertoni, Giulia Paganelli
The aim of this manuscript was the optimization of the synthesis of TiO₂ nanoparticles (TiO₂ NPs) with conditions that could be easily reproducible at the industrial level. Several procedures were tested and those with C12H28O₄Ti and CO(NH₂)₂ as precursors seemed the most promising and, consequently, were improved with different molar ratios, lower temperatures and the addition of NH₄Cl as a secondary dopant of nitrogen. The obtained samples were studied with analytical techniques such as X-ray powder diffraction (XRPD) and field emission scanning electron microscopy (FESEM)...
October 20, 2017: Materials
Ying Kong, Xin Liu, Sha Liu, Yong-Xin Li
BACKGROUND: Cochlear implants (CIs) can improve speech recognition for children with severe congenital hearing loss, and open-set word recognition is an important efficacy measure. This study examined Mandarin open-set word recognition development among Chinese children with CIs and normal hearing (NH). METHODS: This study included 457 children with CIs and 131 children with NH, who completed the Mandarin lexical neighborhood test. The results for children at 1-8 years after receiving their CIs were compared to those from the children with NH using linear regression analysis and analysis of variance...
October 20, 2017: Chinese Medical Journal
Menglong Wang, Yao Xu, Jianfang Liu, Jing Ye, Wenhui Yuan, Huimin Jiang, Zhen Wang, Hong Jiang, Jun Wan
Sestrins (Sesns) have been identified as a family of highly conserved stress-inducible proteins that are strongly up-regulated by various stresses, including DNA damage, oxidative stress, and hypoxia. The Sesns play protective roles in most physiological and pathological conditions mainly through the regulation of oxidative stress, inflammation, autophagy, endoplasmic reticulum stress, and metabolic homeostasis. In this review, we discussed the possible regulators of Sesns expression, such as p53, forkhead box O, nuclear factor erythroid 2 like 2 (Nrf2), NH (2)-terminal kinase (JNK)/c-Jun pathway and hypoxia-inducible factor-1α (Hif-1α), and the downstream pathways regulated by the Sesns including AMP-activated protein kinase (AMPK)/mammalian target of rapamycin (mTOR) signaling, mitogen-activated protein kinases (MAPKs) signaling, Nrf2 signaling, NADPH oxidase signaling and transforming growth factor β (TGF-β) signaling in heart diseases, lung diseases, gastrointestinal tract diseases, liver and metabolism diseases, neurological diseases, kidney diseases and immunological diseases...
October 19, 2017: Cellular Physiology and Biochemistry
Zachary Hass, Mark Woodhouse, Robert Kane, Greg Arling
OBJECTIVE: To build and test a model that predicts community discharge probabilities for Medicaid-eligible nursing home (NH) residents who remain in the nursing home at 90 days after admission and, thus, would be candidates for the Money Follows the Person (MFP) program. DATA SOURCE: The Minimum Data Set, Medicaid Management Information Systems, and Minnesota Vital Statistics file. DATA: Cohort of 33, 590 nursing home stays that qualified for Medicaid by the 90th day of their stay from 383 Minnesota nursing homes from July 2011 to June 2013...
October 18, 2017: Health Services Research
Jian Wen, Hanchao Cheng, Gerhard Raabe, Carsten Bolm
A Cp*Rh(III) complex has been used as catalyst for the preparation of unprecedented 1,2-benzothiazepine 1-oxides by [4 + 3] cyclization of NH-sulfoximines with α,β-unsaturated ketones. For a wide range of substrates with various functional groups, moderate to good product yields were obtained.
October 18, 2017: Organic Letters
Andrew R Zullo, Sadia Sharmin, Yoojin Lee, Lori A Daiello, Nishant R Shah, W John Boscardin, David D Dore, Sei J Lee, Michael A Steinman
BACKGROUND/OBJECTIVES: Secondary prevention medications are recommended for older adults after acute myocardial infarction (AMI), but little is known about whether nursing home (NH) residents receive these medications. The objective was to evaluate new use of secondary prevention medications after AMI in NH residents who were previously nonusers and to evaluate what factors were associated with use. DESIGN: Retrospective cohort using linked national Minimum Data Set assessments; Online Survey, Certification and Reporting records; and Medicare claims...
October 17, 2017: Journal of the American Geriatrics Society
Maikel Herbrink, Herman Vromans, Jan Schellens, Jos Beijnen, Bastiaan Nuijen
The thermal characteristics and the thermal degradation of crystalline and amorphous nilotinib hydrochloride (NH) were studied. The spray drying technique was successfully utilized for the amorphization of NH and was evaluated by spectroscopic techniques and differential scanning calorimetry (DSC). The ethanolic spray drying process yielded amorphous NH with a glass transition temperature (Tg) of 147°C. Thermal characterization of the amorphous phase was performed by heat capacity measurements using modulated DSC (mDSC)...
October 12, 2017: Journal of Pharmaceutical and Biomedical Analysis
A Kessentini, A Ben Ahmed, T Dammak, M Belhouchet
The current work undertakes the growth and the physicochemical properties of a novel green-yellow luminescence semi-organic material, the 3-picolylammonium bromide abbreviated (Pico-Br). In this paper, we report the X-ray diffraction measurements which show that the crystal lattice consists of distinct 3-picolylammonium cations and free bromide anions connected via NH⋯Br and NH⋯N hydrogen bonds leading to form a two dimensional frameworks. Molecular geometry compared with its optimized counterpart shows that the quantum chemical calculations carried out with density functional method (DFT) well produce the perceived structure by X-ray resolution of the studied material...
October 13, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
Zhan Jin, Xinyu Xie, Jin Zhou, Ke Bei, Yejian Zhang, Xianfeng Huang, Min Zhao, Hainan Kong, Xiangyong Zheng
This study assesses the use of vertical greening for blackwater treatment. The effects of hydraulic retention time (HRT) and drip frequency on treatment performance were systematically studied. Additionally, microbial communities in the vertical greening system were characterized. The results show that the removal efficiencies of NH4(+)-N and total phosphate (TP) increased with an increase in HRT, and the drip frequency had a significant effect on TP. High-throughput sequencing revealed that the diversity of the microbial community did not change significantly along vertical and horizontal directions, but the dominant species shifted...
September 28, 2017: Bioresource Technology
Yu Liu, Xiangli Yi, Xuewei Luo, Chanjuan Xi
A metal-free multicomponent domino reaction for the highly regioselective synthesis of tetrasubstituted NH-pyrroles from readily available alkylnitriles, arylalkynes, and MeOTf has been developed. A variety of NH-pyrroles were obtained in moderate to good yields under mild conditions. In addition, the reactions using diarylalkynes with electron-rich aryl groups were found to afford isoquinolines.
October 17, 2017: Journal of Organic Chemistry
Haijin Zhu, Hengrui Yang, Jiaye Li, Kristine J Barlow, Lingxue Kong, David Mecerreyes, Douglas R MacFarlane, Maria Forsyth
Polymeric ionic liquids have emerged recently as a promising alternative to traditional polymers as the polymer electrolyte membrane materials of choice because of their strongly decoupled dynamics between the polymer backbone and the counterions. Knowledge of proton exchange and transport mechanism in such materials is critical to the design and development of new poly(ionic liquid) materials with improved electrochemical properties. Our NMR results show that the proton exchange between the labile proton of the diethylmethylammonium (NH122) cation and H2O molecules is accompanied by a concerted configuration rearrangement of the ammonium...
October 20, 2017: Journal of Physical Chemistry Letters
Lukas Neudert, Dajana Durach, Felix Fahrnbauer, Gavin B M Vaughan, Wolfgang Schnick, Oliver Oeckler
La24Sr14-7x[Si36N72](O1-xFx)14 with x = 0.489 was obtained as a microcrystalline product by metathesis at 1500 °C in a radio-frequency furnace starting from Si(NH)2, La(NH2)3, SrH2, LaF3, and CeF3. The structure of the new nitridosilicate oxide fluoride was determined by combining transmission electron microscopy (TEM) and single-crystal X-ray diffraction using a microfocused synchrotron beam. The structure model with pronounced disorder [P63/mmc, Z = 1, a = 16.2065(3), c = 9.4165(1) Å, R1(obs) = 0.0436] was confirmed by electron diffraction and aberration-corrected Z-contrast scanning TEM...
October 17, 2017: Inorganic Chemistry
C Rodrigues, E Machado, S Fernandes, L Peixe, Â Novais
ESBL-producing Enterobacteriaceae and particularly Escherichia coli ST131 isolates producing CTX-M enzymes are commonly found colonizing the intestine of nursing home (NH) residents, but ST131 subclonal structure has been scarcely explored in this vulnerable population. Our goal was to perform a pilot study to assess the faecal carriage rate and epidemiological features of ESBL- and/or carbapenemase-producing Enterobacteriaceae (ESBL-E and CPE, respectively) among NH residents. For this purpose, faecal samples from residents at 4 different NHs in the North of Portugal (representing 9·5% of the residents' population, July 2014) were screened for ESBL-E and/or CPE by phenotypic and genotypic methods...
October 17, 2017: Epidemiology and Infection
Meenakshi Srivastava, Arun Kumar Mishra
Diazotrophy is considered as one of the most crucial and dynamic phenomena in the rice field and also a major source of nitrogen input. The objective of this study was to elucidate possible interactions between diverse and dominant diazotrophic bacterial community and organic carbon composition of the paddy soil. Our results suggest that most abundantly found diazotrophs belong to a proteobacteria group and uncultured bacterial forms. A gene abundance study clearly showed significantly higher diazotrophic abundance (P < 0...
October 17, 2017: Environmental Science and Pollution Research International
Dengjun Wang, Chang Min Park, Arvid Masud, Nirupam Aich, Chunming Su
Carbon-metal oxide nanohybrids (NHs) are increasingly recognized as the next-generation, promising group of nanomaterials for solving emerging environmental issues and challenges. This research, for the first time, systematically explored the transport and retention of carbon nanotubes-magnetite (CNT-Fe3O4) NH aggregates in water-saturated porous media under environmentally relevant conditions. A macromolecule modifier, carboxymethylcellulose (CMC) was employed to stabilize the NHs. Our results show that transport of the magnetic CNT-Fe3O4 NHs was lower than that of non-magnetic CNT due to larger hydrodynamic sizes of NHs (induced by magnetic attraction) and size-dependent retention in porous media...
October 17, 2017: Environmental Science & Technology
Sandip Mondal, Sachinath Bera, Suvendu Maity, Prasanta Ghosh
The study discloses that the redox activity of N-(1,4-naphthoquinone)-o-aminophenol derivatives (L(R)H2) containing a (phenol)-NH-(1,4-naphthoquinone) fragment is notably different from that of a (phenol)-NH-(phenol) precursor. The former is a platform for a redox cascade. L(R)H2 is redox noninnocent and exists in Cat-N-(1,4-naphthoquinone)(2-) (L(R 2-)) and SQ-N-(1,4-naphthoquinone) (L(R •-)) states in the complexes. Reactions of L(R)H2 with cobalt(II) salts in MeOH in air promote a cascade affording spiro oxazine-oxazepine derivatives ((OX)L(R)) in good yields, when R = H, Me, (t)Bu...
October 16, 2017: Inorganic Chemistry
Arathala Parandaman, Chanin B Tangtartharakul, Manoj Kumar, Joseph S Francisco, Amitabha Sinha
High level ab initio calculations are used to explore the energetics and kinetics for the formation of 1,1-dimethyl urea via the reaction of isocyanic acid (HNCO) with dimethyl amine (DMA) catalyzed by a single water molecule. Compared to the uncatalyzed HNCO+DMA reaction, the presence of a water molecule lowers the reaction barrier, defined here as the energy difference between the separated HNCO+DMA+H2O reactants and the transition state (TS), by ~23 kcal/mol. In addition to the HNCO+DMA+H2O reaction, the energetics of the analogous reactions involving respectively ammonia and methyl amine were also investigated...
October 16, 2017: Journal of Physical Chemistry. A
Ewa Daniela Raczynska, Jean-Francois Gal, Pierre-Charles Maria, Piotr Michalec, Marcin Zalewski
Substituted biguanides are known for their biological effect and a few of them are used as drugs, the most prominent example being metformin (1,1-dimethylbiguanide, IUPAC name: N,N-dimethylimidodicarbonimidic diamide). Owing to the presence of hydrogen atoms at the amino groups, biguanides exhibit a multiple tautomerism. This aspect of their structures was examined in detail for unsubstituted biguanide and metformin in the gas phase. At the DFT level {essentially B3LYP/6-311+G(d,p)}, the most stable structures correspond to the conjugated, push-pull, system (NR2)(NH2)C=N-C(=NH)NH2 (R= H, CH3), further stabilized by an internal hydrogen bond...
October 16, 2017: Journal of Physical Chemistry. A
Mitsuhiko Miyazaki, Ryuhei Ohara, Claude Dedonder, Christophe Jouvet, Masaaki Fujii
Excited-state hydrogen transfer (ESHT) is responsible for various photochemical processes of aromatics, including photoprotection of nuclear basis. Its mechanism is explained by internal conversion from the aromatic ππ* to πσ* states via conical intersection. This means that the electron is transferred to a diffuse Rydberg-like σ* orbital apart from proton migration. This picture means the electron and the proton do not move together and the dynamics are different in principle. Here, we have applied picosecond time-resolved near-infrared (NIR) and infrared (IR) spectroscopies to the phenol-(NH3)5 cluster, the benchmark system of ESHT, and monitored the electron transfer and proton motion independently...
October 15, 2017: Chemistry: a European Journal
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