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https://www.readbyqxmd.com/read/28432738/tick-bite-and-lyme-disease-related-emergency-department-encounters-in-new-hampshire-2010-2014
#1
E R Daly, C Fredette, A A Mathewson, K Dufault, D J Swenson, B P Chan
Lyme disease (LD) is a common tick-borne disease in New Hampshire (NH). While LD is a reportable condition and cases are counted for public health surveillance, many more people receive care for tick bites or diagnoses of LD than are reflected in surveillance data. NH's emergency department (ED) data system was queried for tick bite and LD-related encounters. Chief complaint text was queried for words related to LD or tick bites. International Classification of Diseases 9th Revision (ICD-9) codes were queried for the LD diagnosis code (088...
April 22, 2017: Zoonoses and Public Health
https://www.readbyqxmd.com/read/28431914/pain-trajectories-of-nursing-home-residents-nearing-death
#2
Genevieve N Thompson, Malcolm Doupe, R Colin Reid, Jennifer Baumbusch, Carole A Estabrooks
BACKGROUND/OBJECTIVES: Although examining point in time prevalence of pain among nursing home (NH) residents has value, there is a lack of evidence describing the actual changes (ie, trajectories) in pain that take place during their last 6 months of life. The main objective of this study is to describe the major pain trajectories experienced by NH residents during their last 6 months of life. DESIGN: Secondary analysis of Resident Assessment Instrument-Minimum Data Set (MDS) 2...
April 18, 2017: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/28429376/daily-crying-prevalence-and-associated-factors-in-older-adult-persons-living-in-nursing-homes-findings-from-a-regional-study
#3
Alvisa Palese, Arianna Simeoni, Antonio Ranieri Zuttion, Barbara Ferrario, Sandra Ponta, Elisa Ambrosi
OBJECTIVES: The study aims to evaluate the prevalence of nursing home (NH) resident crying and associated factors at the individual and NH levels. DESIGN: A regional retrospective study design has been used. PARTICIPANTS AND SETTING: A total of 8875 residents, living in 105 NHs, were included. MEASUREMENTS: The occurrence of an episode of crying on at least a daily basis in the last month was the dependent variable; independent variables were set at individual and at the NH levels as reported in the Val...
April 21, 2017: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28429026/n-difluoromethyl-triazole-as-a-constrained-scaffold-in-peptidomimetics
#4
M Mamone, R S B Gonçalves, F Blanchard, G Bernadat, S Ongeri, T Milcent, B Crousse
The N-difluoromethyl triazolo-β-aza-ε-amino acid present in the core of peptides led to constrained conformations due to CH-F and NH-F interactions. Pseudotetrapeptides were obtained in excellent yields directly by click chemistry between azidodifluoroacetamides and alkynes, both linked to an amino acid. This work demonstrates that the N-difluoromethyltriazole scaffold can induce extended structures to β-strand mimics.
April 21, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28428265/inhibition-of-thyroid-hormone-receptor-locally-in-the-retina-is-a-therapeutic-strategy-for-retinal-degeneration
#5
Hongwei Ma, Fan Yang, Michael R Butler, Joshua Belcher, T Michael Redmond, Andrew T Placzek, Thomas S Scanlan, Xi-Qin Ding
Thyroid hormone (TH) signaling regulates cell proliferation, differentiation, and metabolism. Recent studies have implicated TH signaling in cone photoreceptor viability. Using mouse models of retinal degeneration, we demonstrated that antithyroid drug treatment and targeting iodothyronine deiodinases (DIOs) to suppress cellular tri-iodothyronine (T3) production or increase T3 degradation preserves cones. In this work, we investigated the effectiveness of inhibition of the TH receptor (TR). Two genes, THRA and THRB, encode TRs; THRB2 has been associated with cone viability...
April 20, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28425709/beyond-structural-biology-to-functional-biology-solid-state-nmr-experiments-and-strategies-for-understanding-the-m2-proton-channel-conductance
#6
Huajun Qin, Yimin Miao, Timothy A Cross, Riqiang Fu
In terms of structural biology, solid-state NMR experiments and strategies have been well established for resonance assignments leading to the determination of three-dimensional structures of insoluble membrane proteins in their native-like environment. It is also known that NMR has the unique capabilities to characterize structure-function relationships of membrane-bound biological systems beyond structural biology. Here, we report on solid-state NMR experiments and strategies for extracting functional activities on a sub-msec time scale...
April 20, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28425563/differences-in-interregional-brain-connectivity-in-children-with-unilateral-hearing-loss
#7
Matthew E Jung, Miranda Colletta, Rebecca Coalson, Bradley L Schlaggar, Judith E C Lieu
OBJECTIVES: To identify functional network architecture differences in the brains of children with unilateral hearing loss (UHL) using resting-state functional-connectivity magnetic resonance imaging (rs-fcMRI). STUDY DESIGN: Prospective observational study. METHODS: Children (7 to 17 years of age) with severe to profound hearing loss in one ear, along with their normal hearing (NH) siblings, were recruited and imaged using rs-fcMRI. Eleven children had right UHL; nine had left UHL; and 13 had normal hearing...
April 20, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28424695/b-cell-tolerance-to-deiminated-histones-in-balb-c-c57bl-6-and-autoimmune-prone-mouse-strains
#8
Nishant Dwivedi, Annica Hedberg, Ying Yi Zheng, Indira Neeli, Minoru Satoh, Laurence Morel, Ole Petter Rekvig, Marko Radic
Deimination, a posttranslational modification of arginine to citrulline carried out by peptidylarginine deiminases, may compromise tolerance of self-antigens. Patients with connective tissue autoimmunity, particularly rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), or Felty's syndrome, present with autoantibodies to deiminated histones (dH), which thus form a category of antibodies to citrullinated protein antigens (ACPA). In general, ACPA are a sensitive diagnostic for RA and may form in response to the release of nuclear chromatin (DNA plus dH) from granulocytes, usually referred to as neutrophil extracellular traps...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28420170/fisetin-protects-pc12-cells-from-tunicamycin-mediated-cell-death-via-reactive-oxygen-species-scavenging-and-modulation-of-nrf2-driven-gene-expression-sirt1-and-mapk-signaling-in-pc12-cells
#9
Jui-Hung Yen, Pei-Shan Wu, Shu-Fen Chen, Ming-Jiuan Wu
BACKGROUND: Fisetin (3,7,3',4'-tetrahydroxyflavone) is a dietary flavonol and exhibits antioxidant, anti-inflammatory, and neuroprotective activities. However, high concentration of fisetin is reported to produce reactive oxygen species (ROS), induce endoplasmic reticulum (ER) stress and cause cytotoxicity in cancer cells. The aim of this study is to investigate the cytoprotective effects of low concentration of fisetin against tunicamycin (Tm)-mediated cytotoxicity in neuronal-like catecholaminergic PC12 cells...
April 17, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28418685/does-a-physical-activity-program-in-the-nursing-home-impact-on-depressive-symptoms-a-generalized-linear-mixed-model-approach
#10
Mona Diegelmann, Carl-Philipp Jansen, Hans-Werner Wahl, Oliver K Schilling, Eva-Luisa Schnabel, Klaus Hauer
OBJECTIVES: Physical activity (PA) may counteract depressive symptoms in nursing home (NH) residents considering biological, psychological, and person-environment transactional pathways. Empirical results, however, have remained inconsistent. Addressing potential shortcomings of previous research, we examined the effect of a whole-ecology PA intervention program on NH residents' depressive symptoms using generalized linear mixed-models (GLMMs). METHOD: We used longitudinal data from residents of two German NHs who were included without any pre-selection regarding physical and mental functioning (n = 163, Mage = 83...
April 18, 2017: Aging & Mental Health
https://www.readbyqxmd.com/read/28418642/structure-and-dynamics-of-individual-diastereomeric-complexes-on-platinum-surface-studies-related-to-heterogeneous-enantioselective-catalysis
#11
Yi Dong, Guillaume Goubert, Michael N Groves, Jean-Christian Lemay, Bjørk Hammer, Peter H McBreen
The modification of heterogeneous catalysts through the chemisorption of chiral molecules is a method to create catalytic sites for enantioselective surface reactions. The chiral molecule is called a chiral modifier by analogy to the terms chiral auxiliary or chiral ligand used in homogeneous asymmetric catalysis. While there has been progress in understanding how chirality transfer occurs, the intrinsic difficulties in determining enantioselective reaction mechanisms are compounded by the multisite nature of heterogeneous catalysts and by the challenges facing stereospecific surface analysis...
April 18, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/28418449/association-of-a-communication-training-program-with-use-of-antipsychotics-in-nursing-homes
#12
Jennifer Tjia, Jacob N Hunnicutt, Laurie Herndon, Carolyn R Blanks, Kate L Lapane, Susan Wehry
Importance: Off-label antipsychotic prescribing in nursing homes (NHs) is common and is associated with increased risk of mortality in older adults. Prior large-scale, controlled trials in the NH setting failed to show meaningful reductions in antipsychotic use. Objective: To quantify the influence of a large-scale communication training program on NH antipsychotic use called OASIS. Design, Setting, and Participants: This investigation was a quasi-experimental longitudinal study of NHs in Massachusetts enrolled in the OASIS intervention...
April 17, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/28417502/a-quinonoid-imine-enriched-nanostructured-polymer-mediator-for-lithium-sulfur-batteries
#13
Chen-Yu Chen, Hong-Jie Peng, Ting-Zheng Hou, Pei-Yan Zhai, Bo-Quan Li, Cheng Tang, Wancheng Zhu, Jia-Qi Huang, Qiang Zhang
The reversible formation of chemical bonds has potential for tuning multi-electron redox reactions in emerging energy-storage applications, such as lithium-sulfur batteries. The dissolution of polysulfide intermediates, however, results in severe shuttle effect and sluggish electrochemical kinetics. In this study, quinonoid imine is proposed to anchor polysulfides and to facilitate the formation of Li2 S2 /Li2 S through the reversible chemical transition between protonated state (NH(+) ) and deprotonated state (N)...
April 18, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28417111/speech-intelligibility-in-persian-hearing-impaired-children-with-cochlear-implants-and-hearing-aids
#14
Mohammad Rezaei, Maryam Emadi, Peyman Zamani, Farhad Farahani, Gohar Lotfi
The aim of present study is to evaluate and compare speech intelligibility in hearing impaired children with cochlear implants (CI) and hearing aid (HA) users and children with normal hearing (NH). The sample consisted of 45 Persian-speaking children aged 3 to 5-years-old. They were divided into three groups, and each group had 15, children, children with CI and children using hearing aids in Hamadan. Participants was evaluated by the test of speech intelligibility level. Results of ANOVA on speech intelligibility test showed that NH children had significantly better reading performance than hearing impaired children with CI and HA...
April 2017: Journal of Audiology & Otology
https://www.readbyqxmd.com/read/28415475/novel-non-cytotoxic-bioactive-and-biodegradable-hybrid-materials-based-on-polyurethanes-tio2-for-biomedical-applications
#15
Dulce M González-García, L Téllez Jurado, R Jiménez-Gallegos, Luis M Rodríguez-Lorenzo
Titanium compounds have demonstrated great interfacial properties with biological tissues whereas a wide variety of polyurethanes have also been successfully probed in medical applications. However, studies about hybrids based on polyurethanes/TiO2 for medical applications are scarce. The aim of this work is to design novel biodegradable hybrid materials based on polyurethanes/TiO2 (80% organic-20% inorganic) and to perform a preliminary study of the potential applications in bone regeneration. The hybrids have been prepared by a sol-gel reaction using titanium isopropoxide as precursor of the inorganic component and polyurethane as the organic one...
June 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28414961/interaction-between-bacterial-cell-membranes-and-nano-tio2-revealed-by-two-dimensional-ftir-correlation-spectroscopy-using-bacterial-ghost-as-a-model-cell-envelope
#16
Guocheng Huang, Tsz Wai Ng, Taicheng An, Guiying Li, Bo Wang, Dan Wu, Ho Yin Yip, Huijun Zhao, Po Keung Wong
The interaction between microorganisms and nanoparticles is a crucial step towards understanding the subsequent biological effect. In this study, the interaction between TiO2 nanoparticles and bacterial cell membrane was investigated by Two-dimensional Correlation Fourier Transformation Infrared spectroscopy (2D-FTIR-COS) using bacterial ghosts (BGs), which are non-living bacterial cell envelopes devoid of cytoplasm. The synchronous map of 2D-FTIR-COS results indicated that the functionalities in proteins of BGs preferentially interacted with TiO2 nanoparticles; whereas the interaction of TiO2 nanoparticles with characteristic functionality in polysaccharides (COH) and phospholipids (PO) were very weak or insensitive...
April 10, 2017: Water Research
https://www.readbyqxmd.com/read/28414576/hcbs-spending-and-nursing-home-admissions-for-1915%C3%A2-waiver-enrollees
#17
Micah Segelman, Orna Intrator, Yue Li, Dana Mukamel, Peter Veazie, Helena Tempkin-Greener
Medicaid waiver programs for home and community-based services (HCBS) have grown rapidly and serve a population at high risk for nursing home (NH) admission. This study utilized the Medicaid Analytic Extract (MAX) Personal Summary File and the NH Minimum Dataset (MDS) and tested whether higher levels of per beneficiary HCBS spending were associated with: 1) lower risk of long-term (90+ days) NH admission; and 2) higher functional/cognitive impairment at admission, for new enrollees in 1915(c) aged or aged and disabled waiver programs...
April 17, 2017: Journal of Aging & Social Policy
https://www.readbyqxmd.com/read/28414434/ammonia-activation-h2-evolution-and-nitride-formation-from-a-molybdenum-complex-with-a-chemically-and-redox-non-innocent-ligand
#18
Grant W Margulieux, Mate J Bezdek, Zoë R Turner, Paul J Chirik
Treatment of the bis(imino)pyridine molybdenum η6-benzene complex (iPrPDI)Mo(η6-C6H6) (iPrPDI, 2,6-(2,6-iPr2C6H3N=CMe)2C5H3N) with NH3 resulted in coordination in-duced haptotropic rearrangement of the arene to form (iPrPDI)Mo(NH3)2(η2-C6H6). Analogous η2-ethylene and η2-cyclohexene complexes were also synthesized and the latter crystallo-graphically characterized. All three compounds undergo loss of the η2-coordinated ligand followed by N-H bond activation, bis(imino)pyridine modification and H2 loss...
April 17, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28414235/bis-heteroleptic-ruthenium-ii-complex-of-pendant-urea-functionalized-pyridyl-triazole-and-phenathroline-for-recognition-sensing-and-extraction-of-oxyanions
#19
Tamal Kanti Ghosh, Sourav Chakraborty, Bijit Chowdhury, Pradyut Ghosh
A new bis-heteroleptic Ru(II) complex based ditopic receptor, 1[PF6]2, having an anion binding triazole -CH unit and appended 4-fluorophenyl urea arm has been developed. (1)H NMR and isothermal titration calorimetry (ITC) experiments showed binding of 1[PF6]2 toward oxyanions such as phosphates (e.g., H2PO4(-) and HP2O7(3-)) and carboxylates (e.g., CH3CO2(-) and C6H5CO2(-)) anions selectively. (1)H NMR studies showed that highly basic phosphate anions such as HP2O7(3-)/H2PO4(-) are bound by both -CH and -NH units of complex 1[PF6]2...
April 17, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28413747/understanding-tetrahydropyranyl-as-a-protecting-group-in-peptide-chemistry
#20
REVIEW
Anamika Sharma, Iván Ramos-Tomillero, Ayman El-Faham, Ernesto Nicolas, Hortensia Rodriguez, Beatriz G de la Torre, Fernando Albericio
Tetrahydropyranyl (Thp) is recognized as a useful protecting group for alcohols in organic synthesis. It has several advantages, including low cost, ease of introduction, general stability to most non-acidic reagents, it confers good solubility, and the ease with which it can be removed if the functional group it protects requires manipulation. However, little attention has been paid to Thp in peptide chemistry. Provided here is a concise analysis of the Thp protection of various amino acid functionalities (OH, SH, NH and COOH) and its application to peptide synthesis...
April 2017: ChemistryOpen
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