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https://www.readbyqxmd.com/read/28335421/pamam-dendrimers-cross-the-blood-brain-barrier-when-administered-through-the-carotid-artery-in-c57bl-6j-mice
#1
Bhairavi Srinageshwar, Sarah Peruzzaro, Melissa Andrews, Kayla Johnson, Allison Hietpas, Brittany Clark, Crystal McGuire, Eric Petersen, Jordyn Kippe, Andrew Stewart, Olivia Lossia, Abeer Al-Gharaibeh, Aaron Antcliff, Rebecca Culver, Douglas Swanson, Gary Dunbar, Ajit Sharma, Julien Rossignol
Drug delivery into the central nervous system (CNS) is challenging due to the blood-brain barrier (BBB) and drug delivery into the brain overcoming the BBB can be achieved using nanoparticles such as dendrimers. The conventional cationic dendrimers used are highly toxic. Therefore, the present study investigates the role of novel mixed surface dendrimers, which have potentially less toxicity and can cross the BBB when administered through the carotid artery in mice. In vitro experiments investigated the uptake of amine dendrimers (G1-NH₂ and G4-NH₂) and novel dendrimers (G1-90/10 and G4-90/10) by primary cortical cultures...
March 14, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28335355/influence-of-external-gaseous-environments-on-the-electrical-properties-of-zno-nanostructures-obtained-by-a-hydrothermal-method
#2
Marcin Procek, Tadeusz Pustelny, Agnieszka Stolarczyk
This paper deals with experimental investigations of ZnO nanostructures, consisting of a mixture of nanoparticles and nanowires, obtained by the chemical (hydrothermal) method. The influences of both oxidizing (NO₂) and reducing gases (H₂, NH₃), as well as relative humidity (RH) on the physical and chemical properties of ZnO nanostructures were tested. Carrier gas effect on the structure interaction with gases was also tested; experiments were conducted in air and nitrogen (N₂) atmospheres. The effect of investigated gases on the resistance of the ZnO nanostructures was tested over a wide range of concentrations at room temperature (RT) and at 200 °C...
November 29, 2016: Nanomaterials
https://www.readbyqxmd.com/read/28335246/quaternized-carboxymethyl-chitosan-based-silver-nanoparticles-hybrid-microwave-assisted-synthesis-characterization-and-antibacterial-activity
#3
Siqi Huang, Jing Wang, Yang Zhang, Zhiming Yu, Chusheng Qi
A facile, efficient, and eco-friendly approach for the preparation of uniform silver nanoparticles (Ag NPs) was developed. The synthesis was conducted in an aqueous medium exposed to microwave irradiation for 8 min, using laboratory-prepared, water-soluble quaternized carboxymethyl chitosan (QCMC) as a chemical reducer and stabilizer and silver nitrate as the silver source. The structure of the prepared QCMC was characterized using Fourier transform infrared (FT-IR) and ¹H nuclear magnetic resonance (NMR)...
June 17, 2016: Nanomaterials
https://www.readbyqxmd.com/read/28335196/gold-nanomaterial-uptake-from-soil-is-not-increased-by-arbuscular-mycorrhizal-colonization-of-solanum-lycopersicum-tomato
#4
Jonathan D Judy, Jason K Kirby, Mike J McLaughlin, Timothy Cavagnaro, Paul M Bertsch
Bioaccumulation of engineered nanomaterials (ENMs) by plants has been demonstrated in numerous studies over the past 5-10 years. However, the overwhelming majority of these studies were conducted using hydroponic systems and the degree to which the addition of the biological and chemical components present in the soil might fundamentally alter the potential of plant bioaccumulation of ENMs is unclear. Here, we used two genotypes of Solanum lycopersicum (tomato), reduced mycorrhizal colonization (rmc), a mutant which does not allow arbuscular mycorrhizal fungi (AMF) colonization, and its progenitor, 76R, to examine how colonization by AMF alters trends of gold ENM bioaccumulation from a natural soil...
April 13, 2016: Nanomaterials
https://www.readbyqxmd.com/read/28333120/an-analytical-model-for-bds-b1-spreading-code-self-interference-evaluation-considering-nh-code-effects
#5
Xin Zhang, Xingqun Zhan, Shaojun Feng, Washington Ochieng
The short spreading code used by the BeiDou Navigation Satellite System (BDS) B1-I or GPS Coarse/Acquistiion (C/A) can cause aggregately undesirable cross-correlation between signals within each single constellation. This GPS-to-GPS or BDS-to-BDS correlation is referred to as self-interference. A GPS C/A code self-interference model is extended to propose a self-interference model for BDS B1, taking into account the unique feature of the B1-I signal transmitted by BDS medium Earth orbit (MEO) and inclined geosynchronous orbit (IGSO) satellites-an extra Neumann-Hoffmann (NH) code...
March 23, 2017: Sensors
https://www.readbyqxmd.com/read/28330413/molecular-dynamic-simulation-and-dft-study-on-the-drug-dna-interaction-crocetin-as-an-anticancer-and-dna-nanostructure-model
#6
Ebrahim Azarhazin, Mohammad Izadyar, Mohammad Reza Housaindokht
In this research, the interaction of Crocetin as an anticancer drug and a Dickerson DNA has been investigated. 25 ns molecular dynamic simulations of Crocetin and DNA composed of twelve base pairs and a sequence of d(CGCGAATTCGCG)2 were done in water. Three definite parts of the B-DNA were considered in analyzing the best interactive site from the thermodynamic point of view. Binding energy analysis showed that van der Waals interaction is the most important part related to the reciprocal O and H atoms of the Crocetin and DNA...
March 22, 2017: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/28327529/mass-spectrometric-characteristics-of-prenylated-indole-derivatives-from-marine-derived-penicillium-sp-nh-sl
#7
Hui Ding, Wanjing Ding, Zhongjun Ma
Two prenylated indole alkaloids were isolated from the ethyl acetate extracts of a marine-derived fungus Penicillium sp. NH-SL and one of them exhibited potent cytotoxic activity against mouse hepa 1c1c7 cells. In order to detect other bioactive analogs, we used liquid chromatogram tandem mass spectrometry (LC-MS/MS) to analyze the mass spectrometric characteristics of the isolated compounds as well as the crude extracts. As a result, three other analogs were detected, and their structures were deduced according to the similar fragmentation patterns...
March 22, 2017: Marine Drugs
https://www.readbyqxmd.com/read/28324643/unsymmetrical-iron-p-nh-p-catalysts-for-the-asymmetric-pressure-hydrogenation-of-aryl-ketones
#8
Robert Harold Morris, Samantha Alizabeth Michelle Smith, Paraskevi Olympia Lagaditis, Alan J Lough, Anne Lüpke
The reductive amination of -dialkylphosphine acetaldehydes with enantiopure -aminophosphines is a new, versatile route to unsymmetrical tridentate (pincer) ligands P-NH-P'. Four new ligands PR2CH2CH2NHCHR'CHR''PPh2 (R = iPr, Cy, R' = Ph, CH(CH3)2, R'' = Ph, H) prepared in this way are used to make the iron(II) complexes mer-FeCl2(CO)(P-NH-P') and mer-FeCl(H)(CO)(P-NH-P'). The hydride complex with the rigid ligand with R'= R''= Ph is an efficient and highly enantioselective homogeneous asymmetric pressure hydrogenation (APH) catalyst...
March 21, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28320046/increased-insulin-resistance-and-glucagon-levels-in-mild-inactive-systemic-lupus-patients-despite-normal-glucose-tolerance
#9
Cíntia Nh Miyake, Bruno Gualano, Wagner S Dantas, Renato T Pereira, William Neves, Vanessa O Zambelli, Samuel K Shinjo, Rosa M Pereira, Elizabeth R Silva, Ana Lúcia Sá-Pinto, Eduardo Borba, Hamilton Roschel, Eloisa Bonfá, Fabiana B Benatti
OBJECTIVE: To assess insulin sensitivity in patients with systemic lupus erythematosus (SLE) in response to a meal tolerance test (MTT). METHODS: In this cross-sectional study, 33 adult females mild/inactive SLE and 16 age- and body mass index (BMI)-matched female healthy controls (CTRL) underwent a MTT and were assessed for insulin sensitivity and beta-cell function. Skeletal muscle protein expressions of total and membrane GLUT-4 were also evaluated (SLE, n=10; CTRL, n=5); muscle biopsies were performed after MTT...
March 20, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28318583/effects-of-feeding-hull-less-barley-on-production-performance-milk-fatty-acid-composition-and-nutrient-digestibility-of-lactating-dairy-cows
#10
Y Yang, G Ferreira, C L Teets, B A Corl, W E Thomason, C A Griffey
The objectives of this study were to evaluate production performance, milk fatty acid composition, and nutrient digestibility in high-producing dairy cows consuming diets containing corn and hull-less barley (cultivar Amaze 10) in different proportions as the grain source. Eight primiparous and 16 multiparous Holstein cows were assigned to 1 of 4 diets in a replicated 4 × 4 Latin square design with 21-d periods. Cows were fed once daily (1200 h) by means of a Calan gate system (American Calan Inc., Northwood, NH)...
March 16, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28318245/dinuclear-rhenium-complex-with-a-proton-responsive-ligand-as-a-redox-catalyst-for-the-electrochemical-co2-reduction
#11
Alexander Wilting, Thorsten Stolper, Ricardo A Mata, Inke Siewert
Herein, we present the reduction chemistry of a dinuclear α-diimine rhenium complex, 1, [Re2(L)(CO)6Cl2], with a proton responsive ligand and its application as a catalyst in the electrochemical CO2 reduction reaction (L = 4-tert-butyl-2,6-bis(6-(1H-imidazol-2-yl)-pyridin-2-yl)phenol). The complex has a phenol group in close proximity to the active center, which may act as a proton relay during catalysis, and pyridine-NH-imidazole units as α-diimine donors. The complex is an active catalyst for the electrochemical CO2 reduction reaction...
March 20, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28314098/pathways-for-excited-state-nonradiative-decay-of-5-6-dihydroxyindole-a-building-block-of-eumelanin
#12
Avdhoot Datar, Anirban Hazra
The photophysics of 5,6-dihydroxyindole (DHI) following excitation to its lowest two optically bright states has been investigated using the complete active space self consistent field method with second order perturbative energy corrections. There is a barrierless pathway for the molecule to relax from the second lowest bright state (2(1)ππ*) to the lowest bright state (1(1)ππ*). The 1(1)ππ* state has a conical intersection with the optically dark 1(1)πσ* state, which further intersects with the ground state along the NH and OH stretching coordinates...
March 17, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28304172/ab-initio-studies-on-the-clathrate-hydrates-of-some-nitrogen-and-sulfur-containing-gases
#13
Ningru Sun, Zewen Li, Nianxiang Qiu, Xiaohui Yu, Xuran Zhang, Yanjun Li, Longbin Yang, Kan Luo, Qing Huang, Shiyu Du
Ab initio calculations are performed to investigate the host-guest interactions and multiple occupancies of some sulfur- (H2S, CS2) and nitrogen-containing (N2, NO, and NH3) molecules in dodecahedral, tetrakaidecahedral, and hexakaidecahedral water cages in this work. Five functionals in the framework of density functional theory are compared, and the M06-2X method appears to be the best to predict the binding energies as well as the geometries. Results show that N2 and NO molecules are more stable in the 5(12)6(4) cage, while NH3 and H2S prefer to stabilize in the 5(12)6(2) cage...
March 24, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28304048/regioselective-c8-metalation-of-n-phosphine-tethered-adenine-derivatives-via-c8-h-activation
#14
D Brackemeyer, C Schulte To Brinke, F Roelfes, F E Hahn
Two new adenine derivatives bearing a N-methylene (1) or N-ethylene (2) tethered diphenylphosphine group have been reacted with [M(III)Cl2Cp*]2 (M = Ir, Rh) or [Ru(II)ClCp*]4. The formation of Werner-type phosphine complexes [3]-[6] and upon heating their subsequent rearrangement into complexes bearing an NH,NR-NHC^PRPh2 chelate ligand in [7]Cl (M = Ir) and [8] (M = Ru) have been observed.
March 17, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28302507/design-and-synthesis-of-selective-cdk8-19-dual-inhibitors-discovery-of-4-5-dihydrothieno-3-4-3-4-benzo-1-2-d-isothiazole-derivatives
#15
Koji Ono, Hiroshi Banno, Masanori Okaniwa, Takaharu Hirayama, Naoki Iwamura, Yukiko Hikichi, Saomi Murai, Maki Hasegawa, Yuka Hasegawa, Kazuko Yonemori, Akito Hata, Kazunobu Aoyama, Douglas R Cary
To develop a novel series of CDK8/19 dual inhibitors, we employed structure-based drug design using docking models based on a library compound, 4,5-dihydroimidazolo[3',4':3,4]benzo[1,2-d]isothiazole 16 bound to CDK8. We designed various [5,6,5]-fused tricyclic scaffolds bearing a carboxamide group to maintain predicted interactions with the backbone CO and NH of Ala100 in the CDK8 kinase hinge region. We found that 4,5-dihydrothieno[3',4':3,4]benzo[1,2-d]isothiazole derivative 29a showed particularly potent enzymatic inhibitory activity in both CDK8/19 (CDK8 IC50: 0...
February 22, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28301137/conformational-regulation-and-crystalline-manipulation-of-plla-through-a-self-assembly-nucleator
#16
Chunhai Li, Shanshan Luo, Jianfeng Wang, Hong Wu, Shaoyun Guo, Xi Zhang
Self-assembly nucleators have been increasingly used to manipulate the crystallization of PLLA due to their strong intermolecular interaction with PLLA, while the molecular mechanism of such interaction is still unrevealed. In present work, one special self-assembly nucleator (TMC-300) with relatively high solubility in PLLA matrix, is chosen to investigate how the interaction works at molecular level to promote the crystallization of PLLA mainly through time-resolved spectroscopy. The results indicate that due to the dipole-dipole NH…O=C interaction between dissolved TMC-300 and PLLA, PLLA chains are transformed into gt conformer before TMC-300 phase-separating from PLLA melt, resulting in low energy barrier to pass for the following formation of PLLA α-crystal (α-crystal is consisted of gt conformer)...
March 16, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28300771/inhibitors-of-brd4-protein-from-a-marine-derived-fungus-alternaria-sp-nh-f6
#17
Hui Ding, Dashan Zhang, Biao Zhou, Zhongjun Ma
Bromodomains (BRD) are readers of the epigenetic code that regulate gene transcription through their recognition of acetyl-lysine modified histone tails. Recently, bromodomain-containing proteins such as BRD4 have been demonstrated to be druggable through the discovery of potent inhibitors. These protein-protein interaction inhibitors have the potential to modulate multiple diseases by their profound anti-inflammatory and antiproliferative effects. In order to explore new BRD4 inhibitors as well as lead compounds for the development of new drugs, the secondary metabolites of Alternaria sp...
March 16, 2017: Marine Drugs
https://www.readbyqxmd.com/read/28300596/combined-virtual-screening-mmpbsa-molecular-docking-and-dynamics-studies-against-deadly-anthrax-an-in-silico-effort-to-inhibit-bacillus-anthracis-nucleoside-hydrolase
#18
Masoumeh Karami, Chiya Jalali, Sako Mirzaie
Anthrax is a deadly disease caused by Bacillus anthracis, a dangerous biological warfare agent employed for both military and terrorist purposes. A critical selective target for chemotherapy against this disease is nucleoside hydrolase (NH), an enzyme still not found in mammals. In the current study, we have performed molecular docking and dynamics studies, aiming to propose the new potent inhibitors of B. anthracis NH among National Cancer Institute (NCI) Diversity Set. We also analyzed the principal interactions of proposed compounds with the active site residues of NH and the relevant factors to biological activity...
March 12, 2017: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/28299447/markers-of-physiological-stress-during-exercise-under-conditions-of-normoxia-normobaric-hypoxia-hypobaric-hypoxia-and-genuine-high-altitude
#19
David Richard Woods, John Paul O'Hara, Christopher John Boos, Peter David Hodkinson, Costas Tsakirides, Neil Edward Hill, Darren Jose, Amanda Hawkins, Kelly Phillipson, Antonia Hazlerigg, Nicola Arjomandkhah, Liam Gallagher, David Holdsworth, Mark Cooke, Nicholas Donald Charles Green, Adrian Mellor
PURPOSE: To investigate whether there is a differential response at rest and following exercise to conditions of genuine high altitude (GHA), normobaric hypoxia (NH), hypobaric hypoxia (HH), and normobaric normoxia (NN). METHOD: Markers of sympathoadrenal and adrenocortical function [plasma normetanephrine (PNORMET), metanephrine (PMET), cortisol], myocardial injury [highly sensitive cardiac troponin T (hscTnT)], and function [N-terminal brain natriuretic peptide (NT-proBNP)] were evaluated at rest and with exercise under NN, at 3375 m in the Alps (GHA) and at equivalent simulated altitude under NH and HH...
March 15, 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/28296522/effect-of-spatial-separation-and-noise-type-on-sentence-recognition-by-mandarin-speaking-cochlear-implant-users
#20
Yang-Wenyi Liu, Duo-Duo Tao, Ye Jiang, John J GalvinIII, Qian-Jie Fu, Ya-Sheng Yuan, Bing Chen
OBJECTIVES: To investigate the effects of spatial separation and noise type on sentence recognition by unilateral Mandarin-speaking cochlear implant (CI) users and normal-hearing (NH) listeners. METHOD: Twenty-two unilateral Mandarin-speaking CI users and six NH listeners participated in this study. Speech reception thresholds were measured for three noise types (steady state noise, speech babble, and music). Sentences from the Mandarin Speech Perception test were presented directly in front of the listener (0°)...
March 15, 2017: Acta Oto-laryngologica
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