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https://www.readbyqxmd.com/read/29667322/bhlh104-confers-tolerance-to-cadmium-stress-in-arabidopsis-thaliana
#1
Xiani Yao, Yuerong Cai, Diqiu Yu, Gang Liang
Cd is a non-essential heavy metal that is toxic to both plants and animals. Here, we reveal that the transcription factor bHLH104 positively regulates Cd tolerance in Arabidopsis thaliana. We found that Fe deficiency-responsive genes were induced by Cd treatment, and that their upregulation was suppressed in bhlh104 loss-of-function mutants but enhanced upon overexpression of bHLH104. Correspondingly, the bhlh104 mutants displayed sensitivity to Cd stress, whereas plants overexpressing bHLH104 exhibited enhanced Cd tolerance...
April 18, 2018: Journal of Integrative Plant Biology
https://www.readbyqxmd.com/read/29667253/patient-blood-management-what-does-this-actually-mean-for-neonates-and-infants
#2
REVIEW
G L Crighton, H V New, H G Liley, S J Stanworth
Patient blood management (PBM) refers to an evidence-based package of care that aims to improve patient outcomes by optimal use of transfusion therapy, including managing anaemia, preventing blood loss and improving anaemia tolerance in surgical and other patients who may need transfusion. In adults, PBM programmes are well established, yet the definition and implementation of PBM in neonates and children lags behind. Neonates and infants are frequently transfused, yet they are often under-represented in transfusion trials...
April 17, 2018: Transfusion Medicine
https://www.readbyqxmd.com/read/29666436/alterations-in-the-health-of-hibernating-bats-under-pathogen-pressure
#3
Hana Bandouchova, Tomáš Bartonička, Hana Berkova, Jiri Brichta, Tomasz Kokurewicz, Veronika Kovacova, Petr Linhart, Vladimir Piacek, Jiri Pikula, Alexandra Zahradníková, Jan Zukal
In underground hibernacula temperate northern hemisphere bats are exposed to Pseudogymnoascus destructans, the fungal agent of white-nose syndrome. While pathological and epidemiological data suggest that Palearctic bats tolerate this infection, we lack knowledge about bat health under pathogen pressure. Here we report blood profiles, along with body mass index (BMI), infection intensity and hibernation temperature, in greater mouse-eared bats (Myotis myotis). We sampled three European hibernacula that differ in geomorphology and microclimatic conditions...
April 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29665034/metabolic-features-of-nonalcoholic-fatty-liver-nafl-in-obese-adolescents-findings-from-a-multi-ethnic-cohort
#4
Domenico Tricò, Sonia Caprio, Giuseppina Rosaria Umano, Bridget Pierpont, Jessica Nouws, Alfonso Galderisi, Grace Kim, Mariana M Mata, Nicola Santoro
AIMS: We conducted a prospective study in a large, multiethnic cohort of obese adolescents to characterize clinical and genetic features associated with pediatric Non-Alcoholic Fatty Liver (NAFL), the most common cause of chronic liver disease in youth. METHODS: A total of 503 obese adolescents were enrolled, including 191 (38.0%) Caucasians, 134 (26.6%) African Americans, and 178 (35.4%) Hispanics. Participants underwent abdominal magnetic resonance imaging (MRI) to quantify hepatic fat content, an oral glucose tolerance test to assess glucose tolerance and insulin sensitivity, and the genotyping of three SNPs associated with fatty liver (PNPLA3 rs738409, GCKR rs1260326, and TM6SF2 rs58542926)...
April 17, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29664675/knockout-of-glucose-transporter-glut6-has-minimal-effects-on-whole-body-metabolic-physiology-in-mice
#5
Frances L Byrne, Ellen M Olzomer, Robert Brink, Kyle L Hoehn
Glucose transporter 6 (GLUT6) is a member of the facilitative glucose transporter family. GLUT6 is up-regulated in several cancers, but is not widely expressed in normal tissues. Previous studies have shown that GLUT6 knockdown kills endometrial cancer cells that express elevated levels of the protein. However, whether GLUT6 represents a viable anti-cancer drug target is unclear because the role of GLUT6 in normal metabolic physiology is unknown. Herein we generated GLUT6 knockout mice to determine how loss of GLUT6 affected whole body glucose homeostasis and metabolic physiology...
April 17, 2018: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29664502/hospital-acquired-hyponatremia-does-the-type-of-fluid-therapy-affect-children-admitted-to-intensive-care
#6
Pilar Velasco, Andrés J Alcaraz, Niki Oikonomopoulou, Marina Benito, Raquel Moya, Álvaro Sánchez
INTRODUCTION: The objective of this study was to evaluate the association between the type of initial fluid therapy used (isotonic or hypotonic solutions) and the development of hyponatremia, the plas ma chlorine values and the tolerance of venous access. PATIENTS AND METHOD: Retrospective cohort study in a Pediatric Intensive Care Unit (PICU) of a high complexity hospital. There were included children younger than 15 years old hospitalized during the first semester of 2010 and 2013 who recei ved intravenous maintenance fluid therapy, excluding patients undergoing cardiac surgery, kidney transplant and admissions that lasted less than 24 hours...
February 2018: Revista Chilena de Pediatría
https://www.readbyqxmd.com/read/29663944/repair-of-a-large-ventral-hernia-in-a-rhesus-macaque-macaca-mulatta-by-using-an-abdominal-component-separation-technique
#7
Steve J Kempton, Jacqueline S Israel, Saverio Capuano Iii, Samuel O Poore
Here we present a 32-y-old rhesus macaque (Macaca mulatta) with a large recurrent ventral incisional hernia. The initial surgery included midline celiotomy for treatment of endometriosis, in which the animal developed a hernia that was repaired with interposition of mesh. Hernia recurrence at 1 y resulted in a defect measuring 7 × 13 cm, with loss of abdominal domain. Skin breakdown was noted with areas of exposed mesh through the skin with associated acute on chronic infection. Clinically, the animal was lethargic, not eating, and failing to thrive...
April 2, 2018: Comparative Medicine
https://www.readbyqxmd.com/read/29663701/efficacy-and-safety-of-retinaldehyde-0-1-and-0-05-creams-used-to-treat-photoaged-skin-a-randomized-double-blind-controlled-trial
#8
Hyuck Sun Kwon, Ji Hae Lee, Gyong Moon Kim, Jung Min Bae
BACKGROUND: Although topical retinoic acid effectively restores photoaged skin, the associated irritation limits the utility of the material. Retinaldehyde (RAL) is the natural precursor of retinoic acid and can also be used to treat photoaged skin; the safety profile is good. AIMS: To evaluate the efficacy and safety of new anti-aging creams containing RAL at 0.1% and 0.05% used to treat photoaged skin. PATIENTS AND METHODS: We enrolled 40 female Korean volunteers who applied RAL 0...
April 16, 2018: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/29663549/ostreolysin-induces-browning-of-adipocytes-and-ameliorates-hepatic-steatosis
#9
Lili Nimri, Katerina Staikin, Irena Peri, Einav Yehuda-Shnaidman, Betty Schwartz
BACKGROUND AND AIM: Nonalcoholic fatty liver disease (NAFLD) is associated with all features of the metabolic syndrome. Deposition of excess triglycerides in liver cells, a hallmark of NAFLD, is associated with loss of insulin sensitivity. Ostreolysin (Oly) is a 15-kDa fungal protein known to interact with cholesterol-enriched raft-like membrane domains. We aim to test whether a recombinant version of Oly (rOly) can induce functional changes in vitro in adipocytes or in vivo in mice fed a high-fat diet (HFD)...
April 16, 2018: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29663335/long-term-efficacy-of-add-on-lacosamide-treatment-in-children-and-adolescents-with-refractory-epilepsies-a-single-center-observational-study
#10
Anna Rosati, Lucrezia Ilvento, Riccardo Rizzi, Viola Doccini, Maria Carmela Leo, Alessandra Pugi, Salvatore De Masi, Renzo Guerrini
OBJECTIVE: To assess long-term efficacy and tolerability of lacosamide (LCM) as adjunctive treatment through a retrospective study in children and adolescents with refractory epilepsies. METHODS: All patients consecutively treated with LCM as add-on for refractory focal and generalized epilepsy and followed at the Neuroscience Center of Excellence of the Meyer Children's Hospital of Florence between January 2011 and September 2015 were included in the study. Responder rate, relapse-free survival, and retention rate were calculated...
April 17, 2018: Epilepsia
https://www.readbyqxmd.com/read/29662261/prediabetes-in-colombia-expert-consensus
#11
REVIEW
Patricio López-Jaramillo, Carlos Calderón, Jorge Castillo, Iván Darío Escobar, Enrique Melgarejo, Gustavo Adolfo Parra
The prevalence of Prediabetes in Colombia is high, and despite being recognized and categorized in the main Medical Guidelines and included in the International Classification of Diseases in Colombia, knowledge and awareness of it is limited amongst healthcare professionals and in the community. Our expert group recommends that educational programs emphasize a global approach to risk which includes a recognition of the importance of prediabetes and its evaluation along with and other risk factors such as a family history of DM2, overweight and obesity, dislipidemia and hypertension...
December 30, 2017: Colombia Médica: CM
https://www.readbyqxmd.com/read/29661782/doc2b-protects-%C3%AE-cells-against-inflammatory-damage-and-enhances-function
#12
Arianne Aslamy, Eunjin Oh, Erika M Olson, Jing Zhang, Miwon Ahn, Abu Saleh Md Moin, Ragadeepthi Tunduguru, Vishal A Salunkhe, Rajakrishnan Veluthakal, Debbie C Thurmond
Loss of functional β-cell mass is an early feature of type 1 diabetes. To release insulin, β-cells require soluble n-ethylmaleimide-sensitive factor-attachment protein receptor (SNARE) complexes, as well as SNARE complex regulatory proteins like Double C2-domain protein β (DOC2B). We hypothesized that DOC2B deficiency or overabundance may confer susceptibility or protection, respectively, to the functional β-cell mass. Indeed, Doc2b +/- knockout mice show an unusually severe response to multiple-low-dose streptozotocin (MLD-STZ), resulting in more apoptotic β-cells and a smaller β-cell mass...
April 16, 2018: Diabetes
https://www.readbyqxmd.com/read/29659577/transcription-factor-hat1-is-a-substrate-of-snrk2-3-kinase-and-negatively-regulates-aba-synthesis-and-signaling-in-arabidopsis-responding-to-drought
#13
Wenrong Tan, Dawei Zhang, Huapeng Zhou, Ting Zheng, Yanhai Yin, Honghui Lin
Drought is a major threat to plant growth and crop productivity. The phytohormone abscisic acid (ABA) plays a critical role in plant response to drought stress. Although ABA signaling-mediated drought tolerance has been widely investigated in Arabidopsis thaliana, the feedback mechanism and components negatively regulating this pathway are less well understood. Here we identified a member of Arabidopsis HD-ZIP transcription factors HAT1 which can interacts with and be phosphorylated by SnRK2s. hat1hat3, loss-of-function mutant of HAT1 and its homolog HAT3, was hypersensitive to ABA in primary root inhibition, ABA-responsive genes expression, and displayed enhanced drought tolerance, whereas HAT1 overexpressing lines were hyposensitive to ABA and less tolerant to drought stress, suggesting that HAT1 functions as a negative regulator in ABA signaling-mediated drought response...
April 16, 2018: PLoS Genetics
https://www.readbyqxmd.com/read/29659193/pharmacologic-and-pharmacodynamic-equivalence-of-2-formulations-of-orlistat
#14
Steven Johnson, Susan M Schwartz
We sought to establish the bioequivalence of 2 weight-loss aids: orlistat 27-mg chewable tablet and orlistat 60-mg capsule, measured pharmacodynamically as percentage fecal fat excretion. Two open-label, single-center, randomized, 3-period, 3-treatment crossover studies were conducted in adults with body mass index 25-33 kg/m2 . For each 9-day treatment period, subjects received orlistat 27-mg chewable tablet, 60-mg capsule, or 120-mg capsules (2 60-mg capsules) 3 times daily; a 2-day washout separated treatments...
April 16, 2018: Clinical Pharmacology in Drug Development
https://www.readbyqxmd.com/read/29658340/a-novel-use-of-cement-as-a-salvage-procedure-in-patients-with-complex-spinal-injuries-with-proximal-junctional-failure
#15
K Divani, S Selvadurai, S Molloy
Long-construct fixations can be complicated by proximal junctional kyphosis. In elderly, high-risk patients with numerous comorbidities, lengthy surgical times and increased blood loss associated with revision osteotomies and extension of fusions are not often tolerated and pose serious life-threatening risks. We present a salvage technique used in a patient with proximal junctional failure and demonstrate its role in improving symptoms and functionality in those not deemed fit for major surgery. Pre- and postoperative pain scores in accordance with the visual analogue scale, walking distances and radiographs were reviewed in a patient who underwent the salvage technique to ascertain the subjective and objective difference in pain and functionality...
April 16, 2018: Annals of the Royal College of Surgeons of England
https://www.readbyqxmd.com/read/29658290/dietary-restriction-slightly-affects-glucose-homeostasis-and-delays-plasma-cholesterol-removal-in-rabbits-with-dietary-lipid-lowering
#16
Qi Yu, Ruihan Liu, Lijuan Han, Guangwei Zhang, Hua Guan, Qi Pan, Siwang Wang, Enqi Liu
Dietary restriction (DR) has been reported to promote the beneficial effects on atherosclerotic progression, lipid and glucose metabolism, but little is known about these effects can be enhanced or weakened by dietary lipid lowering. After 12 weeks of the high-cholesterol diet (HCD) feeding, hypercholesterolemic rabbits were fed with either a chow diet ad libitum (AL) or a chow diet with DR for 16 weeks of dietary lipid lowering. Here, we found the DR group exhibited a loss in body weight, small internal organs and the reduced fat mass, but the AL group accumulated more subcutaneous fat than the baseline group...
April 15, 2018: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/29658118/transcription-factor-wrky22-promotes-aluminum-tolerance-via-activation-of-osfrdl4-expression-and-enhancement-of-citrate-secretion-in-rice-oryza-sativa
#17
Ge Zi Li, Zhan Qi Wang, Kengo Yokosho, Bing Ding, Wei Fan, Qiao Qiao Gong, Gui Xin Li, Yun Rong Wu, Jian Li Yang, Jian Feng Ma, Shao Jian Zheng
Whilst WRKY transcription factors are known to be involved in diverse plant responses to biotic stresses, their involvement in abiotic stress tolerance is poorly understood. OsFRDL4, encoding a citrate transporter, has been reported to be regulated by ALUMINUM (Al) RESISTANCE TRANSCRIPTION FACTOR 1 (ART1) in rice, but whether it is also regulated by other transcription factors is unknown. We define the role of OsWRKY22 in response to Al stress in rice by using mutation and transgenic complementation assays, and characterize the regulation of OsFRDL4 by OsWRKY22 via yeas one-hybrid, electrophoretic mobility shift assay and ChIP-quantitative PCR...
April 15, 2018: New Phytologist
https://www.readbyqxmd.com/read/29657147/longterm-safety-and-efficacy-of-subcutaneous-abatacept-in-patients-with-rheumatoid-arthritis-5-year-results-from-a-phase-iiib-trial
#18
Mark C Genovese, César Pacheco-Tena, Arturo Covarrubias, Gustavo Leon, Eduardo Mysler, Mauro Keiserman, Robert M Valente, Peter Nash, J Abraham Simon-Campos, Jane Box, Clarence W Legerton, Evgeny Nasonov, Patrick Durez, Ayanbola Elegbe, Robert Wong, Xiaohui Li, Subhashis Banerjee, Rieke Alten
OBJECTIVE: To assess 5-year safety, tolerability, and efficacy of subcutaneous (SC) abatacept (ABA) in methotrexate (MTX)-refractory patients with rheumatoid arthritis (RA). METHODS: The Abatacept Comparison of sub[QU]cutaneous versus intravenous in Inadequate Responders to methotrexatE (ACQUIRE) phase IIIb, randomized, double-dummy, multinational trial compared efficacy and safety of SC and intravenous (IV) ABA in patients with RA. In the initial 6-month double-blind (DB) period, patients received IV or SC ABA, plus MTX, and in the subsequent open-label longterm extension (LTE) period, all patients received SC ABA (125 mg/wk)...
April 15, 2018: Journal of Rheumatology
https://www.readbyqxmd.com/read/29651307/effectiveness-of-gliclazide-mr-60-mg-in-the-management-of-type-2-diabetes-analyses-from-the-easydia-trial
#19
Lawrence A Leiter, Marina V Shestakova, Ilhan Satman
Background: Although the number of antihyperglycemic agents has expanded significantly, sulfonylureas (in particular gliclazide) remain an important option because of a variety of patient and health system factors. The large, real world, observational, and international EASYDia trial evaluated the effectiveness of gliclazide modified release (MR) 60 mg in individuals with type 2 diabetes with a broad range of diabetes history, body mass index (BMI) and background antihyperglycemic treatment...
2018: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/29651292/autoantibodies-to-chemokines-and-cytokines-participate-in-the-regulation-of-cancer-and-autoimmunity
#20
REVIEW
Nathan Karin
We have previously shown that predominant expression of key inflammatory cytokines and chemokines at autoimmune sites or tumor sites induces loss of B cells tolerance, resulting in autoantibody production against the dominant cytokine/chemokine that is largely expressed at these sites. These autoantibodies are high-affinity neutralizing antibodies. Based on animal models studies, we suggested that they participate in the regulation of cancer and autoimmunity, albeit at the level of their production cannot entirely prevent the development and progression of these diseases...
2018: Frontiers in Immunology
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