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https://www.readbyqxmd.com/read/27906376/spin-hall-effect-of-transmitted-light-in-a-three-layer-waveguide-with-lossy-epsilon-near-zero-metamaterial
#1
Tingting Tang, Jie Li, Yanfen Zhang, Chaoyang Li, Li Luo
We study spin Hall effect (SHE) of transmitted light in a three-layer waveguide with epsilon-near-zero (ENZ) metamaterial. As the increased loss of anisotropic ENZ metamaterial brings decreased propagation loss for oblique incidence, the transmission of incident light is enhanced which induces a different distribution of transverse shift peaks. Based on simulation results, the influences of ENZ permittivity components and thickness as well as gold layer thickness on transverse shift of left-circularly polarized light in ENZ/Au/ENZ waveguide are analyzed...
November 28, 2016: Optics Express
https://www.readbyqxmd.com/read/27906079/muscle-specific-loss-of-bmal1-leads-to-disrupted-tissue-glucose-metabolism-and-systemic-glucose-homeostasis
#2
Brianna D Harfmann, Elizabeth A Schroder, Maureen T Kachman, Brian A Hodge, Xiping Zhang, Karyn A Esser
BACKGROUND: Diabetes is the seventh leading cause of death in the USA, and disruption of circadian rhythms is gaining recognition as a contributing factor to disease prevalence. This disease is characterized by hyperglycemia and glucose intolerance and symptoms caused by failure to produce and/or respond to insulin. The skeletal muscle is a key insulin-sensitive metabolic tissue, taking up ~80 % of postprandial glucose. To address the role of the skeletal muscle molecular clock to insulin sensitivity and glucose tolerance, we generated an inducible skeletal muscle-specific Bmal1 (-/-) mouse (iMSBmal1 (-/-))...
March 30, 2016: Skeletal Muscle
https://www.readbyqxmd.com/read/27906072/actrii-blockade-protects-mice-from-cancer-cachexia-and-prolongs-survival-in-the-presence-of-anti-cancer-treatments
#3
Shinji Hatakeyama, Serge Summermatter, Marie Jourdain, Stefan Melly, Giulia C Minetti, Estelle Lach-Trifilieff
BACKGROUND: Cachexia affects the majority of patients with advanced cancer and is associated with reduced treatment tolerance, response to therapy, quality of life, and life expectancy. Cachectic patients with advanced cancer often receive anti-cancer therapies against their specific cancer type as a standard of care, and whether specific ActRII inhibition is efficacious when combined with anti-cancer agents has not been elucidated yet. METHODS: In this study, we evaluated interactions between ActRII blockade and anti-cancer agents in CT-26 mouse colon cancer-induced cachexia model...
July 26, 2016: Skeletal Muscle
https://www.readbyqxmd.com/read/27905090/marker-assisted-breeding-of-the-rice-restorer-line-wanhui-6725-for-disease-resistance-submergence-tolerance-and-aromatic-fragrance
#4
Yanchang Luo, Tingchen Ma, Aifang Zhang, Kar Hui Ong, Zefu Li, Jianbo Yang, Zhongchao Yin
BACKGROUND: Rice is a staple food crop in the world. With the increase in world population and economic development, farmers need to produce more rice in limited field. However, the rice production is frequently affected by biotic and abiotic stresses. The use of natural disease resistance and stress tolerance through genetic breeding is the most efficient and economical way to combat or acclimate to these stresses. In addition, rice with aromatic fragrance can significantly increase market value for its good grain quality...
December 2016: Rice
https://www.readbyqxmd.com/read/27903702/cold-acclimation-improves-chill-tolerance-in-the-migratory-locust-through-preservation-of-ion-balance-and-membrane-potential
#5
Mads Kuhlmann Andersen, Rasmus Folkersen, Heath A MacMillan, Johannes Overgaard
Most insects have the ability to alter their cold tolerance in response to temporal temperature fluctuations, and recent studies have shown that insect cold tolerance is closely tied to the ability to maintain transmembrane ion-gradients that are important for the maintenance of cell membrane potential (Vm). Accordingly, several studies have suggested a link between preservation of Vm and cellular survival after cold stress, but none have measured Vm in this context. We tested this hypothesis by acclimating locusts (Locusta migratoria) to high (31°C) and low temperature (11°C) for four days before exposing them to cold stress (0°C) for up to 48 hours and subsequently measuring ion balance, cell survival, muscle Vm, and whole animal performance...
November 30, 2016: Journal of Experimental Biology
https://www.readbyqxmd.com/read/27901099/post-perovskite-transition-in-anti-structure
#6
Bosen Wang, Kenya Ohgushi
The discovery of the post-perovskite transition, which is the structural transition from the perovskite to post-perovskite structure in MgSiO3 under pressure, has aroused great interests in geosciences. Despite of previous extensive studies, key factors of the post-perovsktie transition are still under hot debate primarily due to the big difficulty in performing systematic experiments under extreme conditions. Hence, search for new materials showing the post-perovskite transition under ambient pressure has been highly expected...
November 30, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27900399/quantitative-trait-loci-mapping-of-heat-tolerance-in-broccoli-brassica-oleracea-var-italica-using-genotyping-by-sequencing
#7
Sandra E Branham, Zachary J Stansell, David M Couillard, Mark W Farnham
Five quantitative trait loci and one epistatic interaction were associated with heat tolerance in a doubled haploid population of broccoli evaluated in three summer field trials. Predicted rising global temperatures due to climate change have generated a demand for crops that are resistant to yield and quality losses from heat stress. Broccoli (Brassica oleracea var. italica) is a cool weather crop with high temperatures during production decreasing both head quality and yield. Breeding for heat tolerance in broccoli has potential to both expand viable production areas and extend the growing season but breeding efficiency is constrained by limited genetic information...
November 29, 2016: TAG. Theoretical and Applied Genetics. Theoretische und Angewandte Genetik
https://www.readbyqxmd.com/read/27900260/gut-microbiota-and-glucometabolic-alterations-in-response-to-recurrent-partial-sleep-deprivation-in-normal-weight-young-individuals
#8
Christian Benedict, Heike Vogel, Wenke Jonas, Anni Woting, Michael Blaut, Annette Schürmann, Jonathan Cedernaes
OBJECTIVE: Changes to the microbial community in the human gut have been proposed to promote metabolic disturbances that also occur after short periods of sleep loss (including insulin resistance). However, whether sleep loss affects the gut microbiota remains unknown. METHODS: In a randomized within-subject crossover study utilizing a standardized in-lab protocol (with fixed meal times and exercise schedules), we studied nine normal-weight men at two occasions: after two nights of partial sleep deprivation (PSD; sleep opportunity 02:45-07:00 h), and after two nights of normal sleep (NS; sleep opportunity 22:30-07:00 h)...
December 2016: Molecular Metabolism
https://www.readbyqxmd.com/read/27899926/bioinformatic-analyses-of-subgroup-a-members-of-the-wheat-bzip-transcription-factor-family-and-functional-identification-of-tabzip174-involved-in-drought-stress-response
#9
Xueyin Li, Biane Feng, Fengjie Zhang, Yimiao Tang, Liping Zhang, Lingjian Ma, Changping Zhao, Shiqing Gao
Extensive studies in Arabidopsis and rice have demonstrated that Subgroup-A members of the bZIP transcription factor family play important roles in plant responses to multiple abiotic stresses. Although common wheat (Triticum aestivum) is one of the most widely cultivated and consumed food crops in the world, there are limited investigations into Subgroup A of the bZIP family in wheat. In this study, we performed bioinformatic analyses of the 41 Subgroup-A members of the wheat bZIP family. Phylogenetic and conserved motif analyses showed that most of the Subgroup-A bZIP proteins involved in abiotic stress responses of wheat, Arabidopsis, and rice clustered in Clade A1 of the phylogenetic tree, and shared a majority of conserved motifs, suggesting the potential importance of Clade-A1 members in abiotic stress responses...
2016: Frontiers in Plant Science
https://www.readbyqxmd.com/read/27899263/adalimumab-dose-escalation-is-effective-and-well-tolerated-in-crohn-s-disease-patients-with-secondary-loss-of-response-to-adalimumab
#10
Nicolas Duveau, Maria Nachury, Romain Gerard, Julien Branche, Vincent Maunoury, Medina Boualit, Pauline Wils, Pierre Desreumaux, Benjamin Pariente
BACKGROUND: Although adalimumab is effective in Crohn's disease, most patients experience a loss of response over time. The aim of the present study was to evaluate efficacy and safety of adalimumab dose escalation and identify predictors of a clinical response in Crohn's disease patients with a secondary loss of response. METHODS: We performed a retrospective and observational study including all Crohn's disease patients who underwent dose escalation of adalimumab after a secondary loss of response from 2007 to 2015...
November 14, 2016: Digestive and Liver Disease
https://www.readbyqxmd.com/read/27895821/implanting-1-1b4-human-%C3%AE-cell-pseudoislets-improves-glycaemic-control-in-diabetic-severe-combined-immune-deficient-mice
#11
Alastair D Green, Srividya Vasu, Neville H McClenaghan, Peter R Flatt
AIM: To investigate the potential of implanting pseudoislets formed from human insulin-releasing β-cell lines as an alternative to islet transplantation. METHODS: In this study, the anti-diabetic potential of novel human insulin releasing 1.1B4 β-cells was evaluated by implanting the cells, either as free cell suspensions, or as three-dimensional pseudoislets, into the subscapular region of severe combined immune deficient mice rendered diabetic by single high-dose administration of streptozotocin...
November 15, 2016: World Journal of Diabetes
https://www.readbyqxmd.com/read/27895554/systemic-radical-scavenger-treatment-of-a-mouse-model-of-rett-syndrome-merits-and-limitations-of-the-vitamin-e-derivative-trolox
#12
Oliwia A Janc, Marc A Hüser, Katharina Dietrich, Belinda Kempkes, Christiane Menzfeld, Swen Hülsmann, Michael Müller
Rett syndrome (RTT) is a severe neurodevelopmental disorder typically arising from spontaneous mutations in the X-chromosomal methyl-CpG binding protein 2 (MECP2) gene. The almost exclusively female Rett patients show an apparently normal development during their first 6-18 months of life. Subsequently, cognitive- and motor-impairment, hand stereotypies, loss of learned skills, epilepsy and irregular breathing manifest. Early mitochondrial impairment and oxidative challenge are considered to facilitate disease progression...
2016: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/27892643/the-rice-osnac6-transcription-factor-orchestrates-multiple-molecular-mechanisms-involving-root-structural-adaptions-and-nicotianamine-biosynthesis-for-drought-tolerance
#13
Dong-Keun Lee, Pil Joong Chung, Jin Seo Jeong, Geupil Jang, Seung Woon Bang, Harin Jung, Youn Shic Kim, Sun-Hwa Ha, Yang Do Choi, Ju-Kon Kim
Drought has a serious impact on agriculture worldwide. A plant's ability to adapt to rhizosphere drought stress requires reprograming of root growth and development. Although physiological studies have documented the root adaption for tolerance to the drought stress, underlying molecular mechanisms is still incomplete, which is essential for crop engineering. Here, we identified OsNAC6-mediated root structural adaptations, including increased root number and root diameter, which enhanced drought tolerance. Multiyear drought field tests demonstrated that the grain yield of OsNAC6 root-specific overexpressing transgenic rice lines was less affected by drought stress than were non-transgenic controls...
November 28, 2016: Plant Biotechnology Journal
https://www.readbyqxmd.com/read/27890728/the-role-of-alkyl-chain-length-of-monothiol-terminated-alkyl-carboxylic-acid-in-the-synthesis-characterization-and-application-of-gelatin-g-poly-n-isopropylacrylamide-carriers-for-antiglaucoma-drug-delivery
#14
Li-Jyuan Luo, Jui-Yang Lai
To improve ocular bioavailability and extend pharmacological response, this study aims to investigate the role of alkyl chain length of monothiol-terminated alkyl carboxylic acids in the synthesis, characterization, and application of gelatin-g-poly(N-isopropylacrylamide) (GN) biodegradable in situ gelling carriers for antiglaucoma drug delivery. In the presence of mercaptoacetic acid (MAA), mercaptopropionic acid (MPA), mercaptobutyric acid (MBA), or mercaptohexanoic acid (MHA) as a chain transfer agent, the carboxylic end-capped poly(N-isopropylacrylamide) samples were prepared by free radical polymerization technique...
November 24, 2016: Acta Biomaterialia
https://www.readbyqxmd.com/read/27889524/early-responses-of-mature-arabidopsis-thaliana-plants-to-reduced-water-potential-in-the-agar-based-polyethylene-glycol-infusion-drought-model
#15
Andrej Frolov, Tatiana Bilova, Gagan Paudel, Robert Berger, Gerd U Balcke, Claudia Birkemeyer, Ludger A Wessjohann
Drought is one of the most important environmental stressors resulting in increasing losses of crop plant productivity all over the world. Therefore, development of new approaches to increase the stress tolerance of crop plants is strongly desired. This requires precise and adequate modeling of drought stress. As this type of stress manifests itself as a steady decrease in the substrate water potential (ψw), agar plates infused with polyethylene glycol (PEG) are the perfect experimental tool: they are easy in preparation and provide a constantly reduced ψw, which is not possible in soil models...
November 10, 2016: Journal of Plant Physiology
https://www.readbyqxmd.com/read/27885975/hearing-benefit-and-rated-satisfaction-in-children-with-unilateral-conductive-hearing-loss-using-a-transcutaneous-magnetic-coupled-bone-conduction-hearing-aid
#16
Melissa J Polonenko, Lora Carinci, Karen A Gordon, Blake C Papsin, Sharon L Cushing
BACKGROUND: Bilateral hearing is important for learning, development, and function in complex everyday environments. Children with conductive and mixed hearing loss (HL) have been treated for years with percutaneous coupling through an abutment, which achieves powerful output, but the implant site is susceptible to skin reactions and trauma. To overcome these complications, transcutaneous magnetic coupling systems were recently introduced. PURPOSE: The purpose of the study was to evaluate whether the new transcutaneous magnetic coupling is an effective coupling paradigm for bone-conduction hearing aids (BCHAs)...
November 2016: Journal of the American Academy of Audiology
https://www.readbyqxmd.com/read/27885538/multi-institutional-prospective-feasibility-study-to-explore-tolerability-and-efficacy-of-oral-nutritional-supplements-for-patients-with-gastric-cancer-undergoing-gastrectomy-ccog1301
#17
Daisuke Kobayashi, Kiyoshi Ishigure, Yoshinari Mochizuki, Hiroshi Nakayama, Mitsuru Sakai, Seiji Ito, Hiroshi Kojima, Masaki Kajikawa, Masahiko Ando, Yasuhiro Kodera
BACKGROUND: Postoperative malnutrition after gastrectomy is deemed inevitable, which could have prejudicial influence on survival for gastric cancer patients. A prospective feasibility study was conducted to evaluate the efficacy of postoperative oral nutritional supplements. METHODS: Stage I-III gastric cancer patients who underwent distal or total gastrectomy received oral administration of Racol(®) NF (Otsuka Pharmaceutical Factory, Japan), a liquid enteral nutritional formula, as a supplement to regular meals...
November 24, 2016: Gastric Cancer
https://www.readbyqxmd.com/read/27884783/secondary-multidrug-efflux-pump-mutants-alter-escherichia-coli-biofilm-growth-in-the-presence-of-cationic-antimicrobial-compounds
#18
Denice C Bay, Carol A Stremick, Carmine J Slipski, Raymond J Turner
Escherichia coli possesses many secondary active multidrug resistance transporters (MDTs) that confer overlapping substrate resistance to a broad range of antimicrobials via proton and/or sodium motive force. It is uncertain whether redundant MDTs uniquely alter cell survival when cultures grow planktonically or as biofilms. In this study, the planktonic and biofilm growth and antimicrobial resistance of 13 E. coli K-12 single MDT gene deletion strains in minimal and rich media were determined. Antimicrobial tolerance to tetracycline, tobramycin and benzalkonium were also compared for each ΔMDT strain...
November 22, 2016: Research in Microbiology
https://www.readbyqxmd.com/read/27884748/isolation-of-bacterial-strains-able-to-degrade-biphenyl-diphenyl-ether-and-the-heat-transfer-fluid-used-in-thermo-solar-plants
#19
Rafael Blanco-Moreno, Lara P Sáez, Víctor M Luque-Almagro, M Dolores Roldán, Conrado Moreno-Vivián
Thermo-solar plants use eutectic mixtures of diphenyl ether (DE) and biphenyl (BP) as heat transfer fluid (HTF). Potential losses of HTF may contaminate soils and bioremediation is an attractive tool for its treatment. DE- or BP-degrading bacteria are known, but up to now bacteria able to degrade HTF mixture have not been described. Here, five bacterial strains which are able to grow with HTF or its separate components DE and BP as sole carbon sources have been isolated, either from soils exposed to HTF or from rhizospheric soils of plants growing near a thermo-solar plant...
November 21, 2016: New Biotechnology
https://www.readbyqxmd.com/read/27884198/use-of-poly-adp-ribose-polymerase-parp-inhibitors-in-cancer-cells-bearing-ddr-defects-the-rationale-for-their-inclusion-in-the-clinic
#20
REVIEW
Aniello Cerrato, Francesco Morra, Angela Celetti
BACKGROUND: DNA damage response (DDR) defects imply genomic instability and favor tumor progression but make the cells vulnerable to the pharmacological inhibition of the DNA repairing enzymes. Targeting cellular proteins like PARPs, which cooperate and complement molecular defects of the DDR process, induces a specific lethality in DDR defective cancer cells and represents an anti-cancer strategy. Normal cells can tolerate the DNA damage generated by PARP inhibition because of an efficient homologous recombination mechanism (HR); in contrast, cancer cells with a deficient HR are unable to manage the DSBs and appear especially sensitive to the PARP inhibitors (PARPi) effects...
November 24, 2016: Journal of Experimental & Clinical Cancer Research: CR
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