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https://www.readbyqxmd.com/read/29457863/the-b-type-natriuretic-peptide-is-a-useful-biomarker-for-the-estimation-of-volume-overload-in-children-with-hypertension-in-children-on-peritoneal-dialysis
#1
Joo Hoon Lee, Young Seo Park
AIM: To evaluate the usefulness of serum B-type natriuretic peptide (BNP) as a biomarker of fluid retention in hypertensive children on peritoneal dialysis (PD). METHODS: We included hypertensive children on PD. We reviewed the changes (∆) of body weight (BWt), blood pressure (BP) and serum BNP at initial and follow-up periods. We presented data as mean±standard deviation (median, minimum - maximum). Wilcoxon signed-rank test was used to evaluate the changes in BWt, BP, and BNP...
February 19, 2018: Nephrology
https://www.readbyqxmd.com/read/29451509/-diagnosis-and-treatment-of-blood-volume-changes-in-acute-heart-failure-a-brief-practical-guide
#2
Paola Ciancetta, Salvatore M Maggiore, Flavia Petrini, Raffaele De Caterina
The correct management of acute heart failure continues to pose diagnostic and therapeutic challenges. In particular, administering the right type and dose of fluids and drugs, thus avoiding fluid overload while establishing organ perfusion, is of key importance in stabilizing critical patients and improving prognosis. A correct estimate of the fluid volume status, however, may be difficult, as the invasive evaluation of cardiac filling pressures by cardiac catheterization is limited in routine medical practice, and there is no universal consensus on the best tools for its non-invasive evaluation...
January 2018: Giornale Italiano di Cardiologia
https://www.readbyqxmd.com/read/29439257/assessing-extracellular-volume-in-hemodialysis-patients-using-intradialytic-blood-pressure-slopes
#3
Hao Liu, Rong Lu, Shani Shastri, Mark Sonderman, Peter Noel Van Buren
BACKGROUND/AIMS: Extracellular volume (ECV) overload is a mortality risk factor in hemodialysis patients, but no standard approach exists to objectively assess this clinically. We aimed to quantify relationships between slopes of repeated intradialytic blood pressure (BP) measurements and ECV. METHODS: In a cross-sectional study of 71 hemodialysis patients, we calculated BP slopes from all intradialytic measurements using Gaussian regression. We measured extracellular and total body water (TBW) with bioimpedance spectroscopy...
February 13, 2018: Nephron
https://www.readbyqxmd.com/read/29435519/analysis-of-the-causes-of-dental-implant-fracture-a-retrospective-clinical-study
#4
Biser Stoichkov, Dimitar Kirov
OBJECTIVE: Fracture of osseointegrated dental implants is the most severe mechanical complication. The aim of the present study was to analyze possible causative factors for implant body fracture. METHOD AND MATERIALS: One hundred and one patients with 218 fitted implants and a follow-up period of 3 to 10 years were studied. Factors associated with biomechanical and physiologic overloading such as parafunctional activity (eg, bruxism), occlusion, and cantilevers, and factors related to the planning of the dental prosthesis, available bone volume, implant area, implant diameter, number of implants, and their inclination were tracked...
February 12, 2018: Quintessence International
https://www.readbyqxmd.com/read/29434729/a-composite-mouse-model-of-aplastic-anemia-complicated-with-iron-overload
#5
Dijiong Wu, Xiaowen Wen, Wenbin Liu, Linlong Xu, Baodong Ye, Yuhong Zhou
Iron overload is commonly encountered during the course of aplastic anemia (AA), but no composite animal model has been developed yet, which hinders drug research. In the present study, the optimal dosage and duration of intraperitoneal iron dextran injection for the development of an iron overload model in mice were explored. A composite model of AA was successfully established on the principle of immune-mediated bone marrow failure. Liver volume, peripheral hemogram, bone marrow pathology, serum iron, serum ferritin, pathological iron deposition in multiple organs (liver, bone marrow, spleen), liver hepcidin, and bone morphogenetic protein 6 (BMP6), SMAD family member 4 (SMAD4) and transferrin receptor 2 (TfR2) mRNA expression levels were compared among the normal control, AA, iron overload and composite model groups to validate the composite model, and explore the pathogenesis and features of iron overload in this model...
February 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29428236/liver-fibrosis-marker-7s-domain-of-collagen-type-iv-in-patients-with-pre-capillary-pulmonary-hypertension
#6
Akiomi Yoshihisa, Yusuke Kimishima, Takatoyo Kiko, Yu Sato, Shunsuke Watanabe, Yuki Kanno, Satoshi Abe, Makiko Miyata-Tatsumi, Takamasa Sato, Satoshi Suzuki, Masayoshi Oikawa, Atsushi Kobayashi, Takayoshi Yamaki, Koichi Sugimoto, Hiroyuki Kunii, Kazuhiko Nakazato, Hitoshi Suzuki, Takafumi Ishida, Yasuchika Takeishi
BACKGROUND: Pulmonary hypertension (PH) causes right ventricular dysfunction and central venous congestion, and may lead to congestive hepatopathy. The serum 7S domain of collagen type IV (P4NP 7S) is an established marker of liver fibrosis in chronic liver disease. We aimed to determine whether P4NP 7S is related to hemodynamic parameters, and assessed the potential values of P4NP 7S to predict mortality. METHODS: Consecutive 76 pre-capillary PH patients were divided into tertiles based on their serum P4NP 7S levels...
February 7, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29427013/assessment-of-fluid-responsiveness-in-spontaneously-breathing-patients-a-systematic-review-of-literature
#7
REVIEW
Renato Carneiro de Freitas Chaves, Thiago Domingos Corrêa, Ary Serpa Neto, Bruno de Arruda Bravim, Ricardo Luiz Cordioli, Fabio Tanzillo Moreira, Karina Tavares Timenetsky, Murillo Santucci Cesar de Assunção
Patients who increase stoke volume or cardiac index more than 10 or 15% after a fluid challenge are usually considered fluid responders. Assessment of fluid responsiveness prior to volume expansion is critical to avoid fluid overload, which has been associated with poor outcomes. Maneuvers to assess fluid responsiveness are well established in mechanically ventilated patients; however, few studies evaluated maneuvers to predict fluid responsiveness in spontaneously breathing patients. Our objective was to perform a systematic review of literature addressing the available methods to assess fluid responsiveness in spontaneously breathing patients...
February 9, 2018: Annals of Intensive Care
https://www.readbyqxmd.com/read/29421004/variation-in-practice-patterns-in-device-closure-of-atrial-septal-defects-and-patent-ductus-arteriosus-an-analysis-of-data-from-the-improving-pediatric-and-adult-congenital-treatment-impact-registry
#8
Michael L O'Byrne, Kevin F Kennedy, Jonathan J Rome, Andrew C Glatz
Practice variation is a potentially important measure of healthcare quality. The IMPACT registry provides a representative national sample with which to study practice variation in trans-catheter interventions for congenital heart disease. METHODS: We studied cases for closure of atrial septal defect (ASD) and patent ductus arteriosus (PDA) in IMPACT between January 1, 2011, and September 30, 2015, using hierarchical multivariate models studying (1) the distribution of indications for closure and (2) in patients whose indication for closure was left (LVVO) or right ventricular volume overload (RVVO), the factors influencing probability of closure of a small defect (either in size or in terms of the magnitude of shunt)...
February 2018: American Heart Journal
https://www.readbyqxmd.com/read/29415313/fetal-cardiac-remodeling-in-response-to-anemia-using-hemoglobin-bart-s-disease-as-a-study-model
#9
Theera Tongsong, Fuanglada Tongprasert, Kasemsri Srisupundit, Suchaya Luewan, Kuntharee Traisrisilp, Phudit Jatavan
OBJECTIVE:  To assess fetal cardiac remodeling in response to anemia, by comparing the fetal cardiac dimensions and global sphericity index (GSI) of normal fetuses and fetuses with anemia using fetal Hb Bart's disease as a study model. METHODS:  Fetuses at risk for Hb Bart's disease undergoing cordocentesis at 18 to 22 weeks of gestation were recruited. Fetal cardiac dimensions including GSI (cardiac length to cardiac width ratio), interventricular septum thickness (IVST), left ventricular wall thickness (LVWT) and right ventricular wall thickness (RVWT) were measured...
February 7, 2018: Ultraschall in der Medizin
https://www.readbyqxmd.com/read/29407589/prognostic-implications-of-low-transferrin-saturation-in-patients-with-primary-myelofibrosis
#10
Marko Lucijanic, Zeljko Prka, Vlatko Pejsa, Tajana Stoos-Veic, Jelena Lucijanic, Rajko Kusec
OBJECTIVES: Transferrin saturation (TSAT) 20% or less is considered to represent functional iron deficiency in the context of malignant disease, phenomenon mediated through inflammatory changes of iron homeostasis. We aimed to investigate clinical and prognostic significance of low TSAT in patients with primary (PMF) and secondary myelofibrosis (SMF), malignant diseases characterized by strong inflammatory milieu. METHODS: We retrospectively analyzed 87 patients with myelofibrosis and compared TSAT with disease specific parameters...
January 29, 2018: Leukemia Research
https://www.readbyqxmd.com/read/29402528/influence-of-chronic-volume-overload-induced-atrial-remodeling-on-electrophysiological-responses-to-cholinergic-receptor-stimulation-in-the-isolated-rat-atria
#11
Xin Cao, Megumi Aimoto, Marie Fukumoto, Yoshinobu Nagasawa, Hikaru Tanaka, Akira Takahara
Whereas molecular mechanisms of atrial fibrillation (AF) have been widely investigated, there is limited information regarding interrelation between chronic volume overload and parasympathetic nervous system in the pathophysiology of AF. In this study, we investigated the influence of abdominal aorto-venocaval shunt (AVS)-induced atrial remodeling on electrophysiological responses to cholinergic receptor stimulation in the isolated rat atria. Interstitial fibrosis, cardiomyocyte hypertrophy and atrial enlargement, known as structural arrhythmogenic substrates for AF, took place after one month of AVS operation...
January 16, 2018: Journal of Pharmacological Sciences
https://www.readbyqxmd.com/read/29401264/stretch-induced-compliance-a-novel-adaptive-biological-mechanism-following-acute-cardiac-load
#12
André M Leite-Moreira, João Almeida-Coelho, João S Neves, Ana L Pires, João Ferreira-Martins, Ricardo Castro-Ferreira, Ricardo Ladeiras-Lopes, Glória Conceição, Daniela Miranda-Silva, Patrícia Rodrigues, Nazha Hamdani, Melissa Herwig, Inês Falcão-Pires, Walter J Paulus, Wolfgang A Linke, André P Lourenço, Adelino F Leite-Moreira
Aims: The heart is constantly challenged with acute bouts of stretching or overload. Systolic adaptations to these challenges are known but adaptations in diastolic stiffness remain unknown. We evaluated adaptations in myocardial stiffness due to acute stretching and characterized the underlying mechanisms. Methods and Results: Left ventricles (LV) of intact rat hearts, rabbit papillary muscles and myocardial strips from cardiac surgery patients were stretched. After stretching, there was a sustained >40% decrease in end-diastolic pressure (EDP) or passive tension (PT) for 15 minutes in all species and experimental preparations...
February 1, 2018: Cardiovascular Research
https://www.readbyqxmd.com/read/29399871/the-correlation-between-cardiac-magnetic-resonance-t2-and-left-ventricular-global-longitudinal-strain-in-people-with-%C3%AE-thalassemia
#13
Mozhgan Parsaee, Nehzat Akiash, Azita Azarkeivan, Zahra Alizadeh Sani, Ahmad Amin, Mahboubeh Pazoki, Niloufar Samiei, Mohammad Ali Jalili, Mohammad Hassan Adel, Nahid Rezaian
BACKGROUND: Heart failure is the biggest cause of mortality and morbidity in people with thalassemia, and iron deposition in cardiac tissue impairs cardiovascular function. Therefore, early detection of cardiac involvement is important to improve the prognosis in these individuals. METHOD: Two- and three-dimensional echocardiography was performed to evaluate left ventricular ejection fraction (LVEF), left ventricular volumes and diameters, and global longitudinal strain (GLS) in 130 individuals with β-thalassemia using the speckle tracking method...
February 4, 2018: Echocardiography
https://www.readbyqxmd.com/read/29389698/goal-directed-fluid-resuscitation-protocol-based-on-arterial-waveform-analysis-of-major-burn-patients-in-a-mass-burn-casualty
#14
Hao-Yu Chiao, Chang-Yi Chou, Yuan-Sheng Tzeng, Chih-Hsin Wang, Shyi-Gen Chen, Niann-Tzyy Dai
BACKGROUND: Adequate fluid titration during the initial resuscitation period of major burn patients is crucial. This study aimed to evaluate the feasibility and efficacy of a goal-directed fluid resuscitation protocol that used hourly urine output plus the arterial waveform analysis FloTrac (Edwards LifeSciences, Irvine, Calif) system for major burns to avoid fluid overload. METHODS: We conducted a retrospective cohort study of 43 major burn patients at the Tri-Service General Hospital after the Formosa Fun Coast Dust Explosion on June 27, 2015...
January 31, 2018: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29386302/does-routine-bioimpedance-guided-fluid-management-provide-additional-benefit-to-non-anuric-peritoneal-dialysis-patients-results-from-compass-clinical-trial
#15
Kook-Hwan Oh, Seon Ha Baek, Kwon-Wook Joo, Dong Ki Kim, Yon-Su Kim, Sejoong Kim, Yun Kyu Oh, Byoung Geun Han, Jae Hyun Chang, Wookyung Chung, Ki Young Na
INTRODUCTION: In peritoneal dialysis (PD) patients, volume overload is related to cardiac dysfunction and mortality, while intravascular volume depletion is associated with a rapid decline in the residual renal function (RRF). This study sought to determine the clinical usefulness of bioimpedance spectroscopy (BIS)-guided fluid management for preserving RRF and cardiac function in PD patients. SUBJECTS AND METHODS: This is a multicenter, prospective, open-label study that was conducted over a 1-year period (NCT01887262)...
January 31, 2018: Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis
https://www.readbyqxmd.com/read/29379040/mri-of-the-cervical-spinal-cord-predicts-respiratory-dysfunction-in-als
#16
G Grolez, M Kyheng, R Lopes, C Moreau, K Timmerman, F Auger, G Kuchcinski, A Duhamel, P Jissendi-Tchofo, P Besson, C Laloux, M Petrault, J C Devedjian, Thierry Pérez, Pierre François Pradat, L Defebvre, R Bordet, V Danel-Brunaud, D Devos
For patients with amyotrophic lateral sclerosis (ALS), the primary therapeutic goal is to minimize morbidity. Non-invasive ventilation improves survival. We aim to assess whether Magnetic Resonance Imaging (MRI) of the cervical spinal cord predicts the progression of respiratory disorders in ALS. Brain and spinal MRI was repeatedly performed in the SOD1G86R mouse model, in 40 patients and in healthy controls. Atrophy, iron overload, white matter diffusivity and neuronal loss were assessed. In Superoxide Dismutase-1 (SOD1) mice, iron accumulation appeared in the cervical spinal cord at symptom onset but disappeared with disease progression (after the onset of atrophy)...
January 29, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29378757/systemic-right-ventricle-in-adults-with-congenital-heart-disease-anatomic-and-phenotypic-spectrum-and-current-approach-to-management
#17
REVIEW
Margarita Brida, Gerhard-Paul Diller, Michael A Gatzoulis
The systemic right ventricle (SRV) is commonly encountered in congenital heart disease representing a distinctly different model in terms of its anatomic spectrum, adaptation, clinical phenotype, and variable, but overall guarded prognosis. The most common clinical scenarios where an SRV is encountered are complete transposition of the great arteries with previous atrial switch repair, congenitally corrected transposition of the great arteries, double inlet right ventricle mostly with previous Fontan palliation, and hypoplastic left heart syndrome palliated with the Norwood-Fontan protocol...
January 30, 2018: Circulation
https://www.readbyqxmd.com/read/29377313/sost-sclerostin-improves-post-traumatic-osteoarthritis-and-inhibits-mmp2-3-expression-after-injury
#18
Jiun C Chang, Blaine A Christiansen, Deepa K Murugesh, Aimy Sebastian, Nicholas R Hum, Nicole M Collette, Sarah Hatsell, Aris N Economides, Craig D Blanchette, Gabriela G Loots
Patients with anterior cruciate ligament (ACL) rupture are 2X as likely to develop post traumatic osteoarthritis (PTOA). Annually, there are ∼900,000 knee injuries in the US, which account for ∼12% of all OA cases. PTOA leads to reduced physical activity, deconditioning of the musculoskeletal system and in severe cases, requires joint replacement to restore function. Therefore, treatments that would prevent cartilage degradation post injury would provide attractive alternatives to surgery. Sclerostin (Sost), a Wnt antagonist and a potent negative regulator of bone formation has recently been implicated in regulating chondrocyte function in osteoarthritis (OA)...
January 26, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29369739/organ-level-right-ventricular-dysfunction-with-preserved-frank-starling-mechanism-in-a-mouse-model-of-pulmonary-arterial-hypertension
#19
Zhijie Wang, Jitandrakumar R Patel, David A Schreier, Timothy A Hacker, Richard L Moss, Naomi C Chesler
Pulmonary arterial hypertension (PAH) is a rapidly fatal disease in which mortality is due to right ventricular (RV) failure. It is unclear whether RV dysfunction initiates at the organ-level or the subcellular-level or both. We hypothesized that chronic pressure overload-induced RV dysfunction begins at the organ level with preserved Frank-Starling mechanism in myocytes. To test this hypothesis, we induced PAH with SUGEN+hypoxia (HySu) in mice and measured RV whole-organ and subcellular functional changes by in vivo pressure-volume measurements and in vitro trabeculae length-tension measurements, respectively at multiple time points for up to 56 days...
January 25, 2018: Journal of Applied Physiology
https://www.readbyqxmd.com/read/29367547/the-dark-side-of-the-moon-the-right-ventricle
#20
REVIEW
Massimiliano Foschi, Michele Di Mauro, Fabrizio Tancredi, Carlo Capparuccia, Renata Petroni, Luigi Leonzio, Silvio Romano, Sabina Gallina, Maria Penco, Mario Cibelli, Antonio Calafiore
The aim of this review article is to summarize current knowledge of the pathophysiology underlying right ventricular failure (RVF), focusing, in particular, on right ventricular assessment and prognosis. The right ventricle (RV) can tolerate volume overload well, but is not able to sustain pressure overload. Right ventricular hypertrophy (RVH), as a response to increased afterload, can be adaptive or maladaptive. The easiest and most common way to assess the RV is by two-dimensional (2D) trans-thoracic echocardiography measuring surrogate indexes, such as tricuspid annular plane systolic excursion (TAPSE), fractional area change (FAC), and tissue Doppler velocity of the lateral aspect of the tricuspid valvular plane...
October 20, 2017: Journal of Cardiovascular Development and Disease
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