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JOURNAL ARTICLE
Jesús Domínguez, Denys Prociuk, Branko Marović, Kristijonas Čyras, Oana Cocarascu, Francis Ruiz, Ella Mi, Emma Mi, Christian Ramtale, Antonio Rago, Ara Darzi, Francesca Toni, Vasa Curcin, Brendan Delaney
INTRODUCTION: Clinical decision support (CDS) systems (CDSSs) that integrate clinical guidelines need to reflect real-world co-morbidity. In patient-specific clinical contexts, transparent recommendations that allow for contraindications and other conflicts arising from co-morbidity are a requirement. In this work, we develop and evaluate a non-proprietary, standards-based approach to the deployment of computable guidelines with explainable argumentation, integrated with a commercial electronic health record (EHR) system in Serbia, a middle-income country in West Balkans...
April 2024: Learning Health Systems
#2
JOURNAL ARTICLE
Juliana C N Chan, Chun-Kwan O, Andrea O Y Luk
Precision diagnosis is the keystone of clinical medicine. In East Asians, classical type 1 diabetes is uncommon in patients with youngonset diabetes diagnosed before age of 40, in whom a family history, obesity, and beta-cell and kidney dysfunction are key features. Young-onset diabetes affects one in five Asian adults with diabetes in clinic settings; however, it is often misclassified, resulting in delayed or non-targeted treatment. Complex aetiologies, long disease duration, aggressive clinical course, and a lack of evidence-based guidelines have contributed to variable care standards and premature death in these young patients...
April 16, 2024: Endocrinology and Metabolism
#3
JOURNAL ARTICLE
Camille Godet, Charles Sabbagh, Laura Beyer-Berjot, Mehdi Ouaissi, Philippe Zerbib, Bridoux Valérie, Gilles Manceau, Yves Panis, Etienne Buscail, Aurélien Venara, Iman Khaoudy, Martin Gaillard, Manon Viennet, Alexandre Thobie, Benjamin Menahem, Clarisse Eveno, Catherine Bonnel, Jean-Yves Mabrut, Bogdan Badic, Julien Chautard, Yassine Eid, Emilie Duchalais, Zaher Lakkis, Eddy Cotte, Anaïs Laforest, Véronique Desfourneaux-Denis, Léon Maggiori, Lionel Rebibo, Christou Niki, Ali Talal, Diane Mege, Cécile Bonnamy, Adeline Germain, François Mauvais, Christophe Tresallet, Jean Roudie, Alexis Laurent, Bertrand Trilling, Martin Bertrand, Damien Massalou, Benoit Romain, Hadrien Tranchart, Alexandra Pellegrin, Olivier Dejardin, Arnaud Alves
BACKGROUND: The observed increase in the incidence of complicated diverticulitis may lead to the performance of more emergency surgeries. This study aimed to assess the rate and risk factors of emergency surgery for sigmoid diverticulitis. METHOD: The primary outcomes were the rate of emergency surgery for sigmoid diverticulitis and its associated risk factors. The urgent or elective nature of the surgical intervention was provided by the surgeon and in accordance with the indication for surgical treatment...
April 11, 2024: Surgery
#4
JOURNAL ARTICLE
Atsushi Shinonaga, Shigeharu Tanaka, Takashi Tsuru, Yuya Sato, Masahiro Taguchi, Ryosuke Takane
BACKGROUND: The effectiveness of a high level of physical activity in maintaining physical function in patients with hip osteoarthritis has not been adequately examined. OBJECTIVE: This study aimed to determine whether self-reported physical activity is associated with physical function and walking ability in female patients with hip osteoarthritis. METHODS: This was a multicenter cross-sectional study. The dependent variables were the lower-limb range of motion and muscle strength, and walking ability...
April 11, 2024: Physiotherapy Theory and Practice
#5
JOURNAL ARTICLE
Veronika Dill, Philipp Blüm, Anja Lindemann, Alexander Biederstädt, Marion Högner, Katharina S Götze, Florian Bassermann, Martin Hildebrandt
BACKGROUND: Despite recent advances in the treatment of multiple myeloma, high-dose chemotherapy followed by autologous hematopoietic stem cell transplantation (ASCT) remains an essential therapeutic keystone. As for the stem cell mobilization procedure, different regimens have been established, usually consisting of a cycle of chemotherapy followed by application of granulocyte-colony stimulating factor (G-CSF), although febrile neutropenia is a common complication. Following national guidelines, our institution decided to primarily use G-CSF only mobilization during the COVID-19 pandemic to minimize the patients' risk of infection and to reduce the burden on the health system...
April 10, 2024: Transfusion
#6
REVIEW
Felix Mahfoud, Jiguang Wang, Saumitra Ray
The benefits of improved clinical outcomes through blood pressure (BP) reduction have been proven in multiple clinical trials and meta-analyses. The new (2023) guideline from the European Society of Hypertension (ESH) includes β-blockers within five main classes of antihypertensive agents suitable for initiation of antihypertensive pharmacotherapy and for combination with other antihypertensive agents. This is in contrast to the 2018 edition of ESH guidelines that recommended β-blockers for use primarily in patients with compelling indications such as cardiovascular comorbidities, e...
2024: Current Medical Research and Opinion
#7
JOURNAL ARTICLE
Jayalakshmi Venugopal, Shalini S, Rajasekaran A, Deepika Karnan
BACKGROUND: Cancer patients are at a significantly increased risk of drug-related problems due to multiple drugs. An inclusive review of drug-related problems would offer an approach for healthcare providers to decrease the frequency of drug-related problems in cancer patients. The purpose of this study was to assess all characteristic components of drug-related problems in cancer patients, and explore actions taken to resolve the detected drug-related problems the results could be used as a baseline for epidemiology and potential related risk factors for drug-related problems in cancer patients...
April 9, 2024: Journal of Oncology Pharmacy Practice
#8
JOURNAL ARTICLE
Nadeem Bin Nusrat, Assad Ur Rehman, Nauman Zafar, Shujah Muhammad, Sarmad Imtiaz Bajwa, Saira Imtiaz
OBJECTIVE: To evaluate long-term outcomes in patients homogenously treated with radical cystectomy and ileal conduit for muscle invasive bladder cancer. METHODS: The retrospective study was conducted at the Urology Department of Pakistan Kidney and Liver Institute and Research Centre, Lahore, Pakistan, and comprised data from December 25, 2017, to January 16, 2023, related to patients who underwent radical cystectomy with ileal conduit with or without neo-adjuvant and adjuvant radiation, chemotherapy, or immunotherapy for papillary urothelial carcinom of the bladder...
March 2024: JPMA. the Journal of the Pakistan Medical Association
#9
JOURNAL ARTICLE
Nathalia Garrido-Torres, Renata Marqués Rodríguez, María Alemany-Navarro, Javier Sánchez-García, Susana García-Cerro, María Irene Ayuso, Antonio González-Meneses, Amalia Martinez-Mir, Miguel Ruiz-Veguilla, Benedicto Crespo-Facorro
Several studies show great heterogeneity in the type of genetic test requested and in the clinicopathological characteristics of patients with ASD. The following study aims, firstly, to explore the factors that might influence professionals' decisions about the appropriateness of requesting genetic testing for their patients with ASD and, secondly, to determine the prevalence of genetic alterations in a representative sample of children with a diagnosis of ASD. Methods: We studied the clinical factors associated with the request for genetic testing in a sample of 440 children with ASD and the clinical factors of present genetic alterations...
April 8, 2024: European Child & Adolescent Psychiatry
#10
JOURNAL ARTICLE
Taro Kojima
After the publication of the guidelines about the safe drug therapy for older people in 2015 by the Japan Geriatrics Society, the risk of polypharmacy has become popular. Older people are likely to have multimorbidity, resulting in the use of multiple drugs. This not only increases the frequency of side effects, but also increase confusion and difficulty in medication management and adherence. Polypharmacy is the problem related to these complicated drug therapies and will increase by age. It is necessary to review drugs and resolve polypharmacy without making comorbid conditions worth...
2024: Nihon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics
#11
REVIEW
André Luiz Schuh Teixeira da Rosa, Olivia Sorato Bezerra, Luis Augusto Rohde, Ana Soledade Graeff-Martins
BACKGROUND: Patients with autism spectrum disorder (ASD) may experience severe psychiatric symptoms, often unresponsive to conventional pharmacological therapies, highlighting the need for more effective alternatives. AIMS: This study aims to map and synthesize evidence on the use of clozapine as a therapeutic option for managing severe psychiatric symptomatology co-occurring with ASD. METHODS: We conducted a scoping review on multiple sources following the JBI guidelines...
April 4, 2024: Journal of Psychopharmacology
#12
Marie-Louis Wronski, Ralf Kuja-Halkola, Elin Hedlund, Miriam I Martini, Paul Lichtenstein, Sebastian Lundström, Henrik Larsson, Mark J Taylor, Nadia Micali, Cynthia M Bulik, Lisa Dinkler
BACKGROUND: Avoidant restrictive food intake disorder (ARFID) is a feeding and eating disorder, characterized by limited variety and/or quantity of food intake impacting physical health and psychosocial functioning. Children with ARFID often present with a range of psychiatric and somatic symptoms, and therefore consult various pediatric subspecialties; large-scale studies mapping comorbidities are however lacking. To characterize health care needs of people with ARFID, we systematically investigated ARFID-related mental and somatic conditions in 616 children with ARFID and >30,000 children without ARFID...
March 15, 2024: medRxiv
#13
JOURNAL ARTICLE
Deborah E Malden, John M McLaughlin, Vennis Hong, Joseph Lewnard, Bradley K Ackerson, Laura Puzniak, Jeniffer S Kim, Harpreet Takhar, Timothy B Frankland, Jeff M Slezak, Sara Y Tartof
A clear understanding of real-world uptake of nirmatrelvir-ritonavir for treatment of SARS-CoV-2 can inform treatment allocation strategies and improve interpretation of effectiveness studies. We used data from a large US healthcare system to describe nirmatrelvir-ritonavir dispenses among all SARS-CoV-2 positive patients aged ≥ 12 years meeting recommended National Institutes of Health treatment eligibility criteria for the study period between 1 January and 31 December, 2022. Overall, 10...
March 29, 2024: Scientific Reports
#14
Hitesh P Rai, Cameron Sandefur
Tuberous sclerosis complex (TSC) is a neurocutaneous disease that manifests across multiple body systems. While there are substantial guidelines and protocols for managing the physical presentation of the disease, managing the psychosocial factors and the adverse effects as a social determinant of health is complex and unclear. This study discusses a patient with TSC who was hospitalized for pneumonia and how both her psychiatric and somatic symptoms were managed. Here we present the case of a 38-year-old Caucasian female with shortness of breath and generalized weakness...
February 2024: Curēus
#15
JOURNAL ARTICLE
Adina Greene, Scott Penner, Jacqueline Kunesh, Amal Altaf, William McGrade, Jiaxin Niu
OBJECTIVE: We report a case of a 77-year-old male with metastatic melanoma who developed immune-checkpoint-inhibitor (ICI) induced type 1 diabetes mellitus (T1DM) after seven months of pembrolizumab treatment and required life-long insulin use. This prompted a literature review of best practice guidelines for long-term management of checkpoint-inhibitor induced T1DM including oral steroids as a treatment option similar to other ICI adverse effects. DATA SOURCES AND SUMMARY: A literature search on PubMed was conducted to evaluate the efficacy of steroid treatment ICI-induced T1DM in any cancer type...
March 28, 2024: Journal of Oncology Pharmacy Practice
#16
REVIEW
Vasileios Giannopapas, Maria-Ioanna Stefanou, Vassiliki Smyrni, Dimitrios K Kitsos, Maria Kosmidou, Sophia Stasi, Athanasios K Chasiotis, Konstantina Stavrogianni, Georgia Papagiannopoulou, John S Tzartos, George P Paraskevas, Georgios Tsivgoulis, Sotirios Giannopoulos
Background: While obesity has been shown to elevate the risk of developing multiple sclerosis (MS), there is a lack of strong evidence regarding its role in the disability progression and status of MS patients. Methods: This systematic review and meta-analysis aimed to provide comparative estimates of WC and BMI in patients with MS (PwMS) and to investigate potential associations between the waist circumference (WC) and body mass index (BMI) and demographic and specific MS characteristics. Adhering to PRISMA guidelines, a detailed search of the MEDLINE PubMed, Cochrane Library, and Scopus databases was conducted...
March 18, 2024: Journal of Clinical Medicine
#17
REVIEW
Jaleel Jerry G Sweis, Fatima Alnaimat, Valeria Esparza, Supritha Prasad, Abeera Azam, Zeel Modi, Mina Al-Awqati, Pim Jetanalin, Nadia J Sweis, Christian Ascoli, Richard M Novak, Israel Rubinstein, Ilias C Papanikolaou, Nadera Sweiss
The COVID-19 pandemic has resulted in a growing number of patients experiencing persistent symptoms and physiological changes after recovering from acute SARS-CoV-2 infection, known as Long COVID. Long COVID is characterized by recurring symptoms and inflammation across multiple organ systems. Diagnosis can be challenging, influenced by factors like demographics, comorbidities, and immune responses. Long COVID impacts various organ systems and can have neuropsychological effects. Health disparities, particularly related to race, contribute to a higher burden of infection and ongoing symptoms in minority populations...
March 11, 2024: International Journal of Environmental Research and Public Health
#18
REVIEW
Soulandi Djorwé, Amale Bousfiha, Néhémie Nzoyikorera, Joseph Nyandwi, Bellamine Kawthar, Abderrahim Malki
BACKGROUND: COVID-19 patients usually present multiple comorbidities and complications associated with severe forms of SARS-CoV-2 infection. This study aimed to assess the risk factors and prevalence of comorbidities and complications contributing to the severity of COVID-19. METHODS: This meta-analysis was performed according to PRISMA guidelines. We searched various databases, including PubMed, Google Scholar, and Scopus (between 2020 and 2023), for eligible studies for this meta-analysis...
2024: BioMedicine
#19
JOURNAL ARTICLE
Yi-Heng Li, Chun-Chieh Wang, Chung-Lieh Hung, Yen-Wen Wu, Chih-Hsin Hsu, Yi-Liang Tsou, Chao-Hung Wang, Cho-Kai Wu, Po-Lin Lin, Hung-Yu Chang, Shih-Hsien Sung, Zheng-Wei Chen, Jyh-Ming Jimmy Juang, Tzung-Dau Wang, Wen-Jone Chen
Heart failure with preserved ejection fraction (HFpEF) is a multi-organ systemic syndrome that involves cardiac and extra-cardiac pathophysiological abnormalities. Its growing prevalence causes a major public concern worldwide. HFpEF is usually associated with multiple comorbidities, and non-cardiovascular death is common in patients with HFpEF. In Asia, patients with HFpEF has a younger age, higher prevalence of diabetes and chronic kidney disease than Western countries. A 2-step diagnostic algorithm is recommended in this guideline...
March 2024: Acta Cardiologica Sinica
#20
JOURNAL ARTICLE
Nicholas Siegel, Mark J Lambrechts, Parker L Brush, Alexa Tomlak, Yunsoo Lee, Brian A Karamian, Jose A Canseco, Barrett I Woods, I David Kaye, Alan S Hilibrand, Christopher K Kepler, Alexander R Vaccaro, Gregory D Schroeder
STUDY DESIGN: Retrospective cohort. OBJECTIVE: The objectives were to (1) compare the safety of spine surgery before and after the emergence of coronavirus disease 2019 (COVID-19) and (2) determine whether patients with a history of COVID-19 were at increased risk of adverse events. SUMMARY AND BACKGROUND DATA: The COVID-19 pandemic had a tremendous impact on several health care services. In spine surgery, elective cases were canceled and patients received delayed care due to the uncertainty of disease transmission and surgical outcomes...
April 1, 2024: Clinical Spine Surgery
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