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Lipidomics and cancer

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https://www.readbyqxmd.com/read/29316682/effect-of-omega-3-fatty-acid-supplementation-on-oxylipins-in-a-routine-clinical-setting
#1
Christoph Schmöcker, Ingrid W Zhang, Stefanie Kiesler, Ursula Kassner, Annika I Ostermann, Elisabeth Steinhagen-Thiessen, Nils H Schebb, Karsten-H Weylandt
Omega-6 polyunsaturated fatty acid (n-6 PUFA) is the predominant polyunsaturated fatty acid (PUFA), especially in Western diet. A high omega-6/omega-3 ratio in Western diets is implicated in the development of cardiovascular diseases and inflammatory processes. Studies in animal models and in humans have demonstrated beneficial effects of omega-3 PUFA (n-3 PUFA) in a variety of diseases, including cardiac arrhythmias and inflammatory diseases, as well as breast and colon cancer. The molecular mechanisms underlying the effects of n-3 PUFA are still not well understood...
January 8, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29301511/a-quantitative-multimodal-metabolomic-assay-for-colorectal-cancer
#2
Farshad Farshidfar, Karen A Kopciuk, Robert Hilsden, S Elizabeth McGregor, Vera C Mazurak, W Donald Buie, Anthony MacLean, Hans J Vogel, Oliver F Bathe
BACKGROUND: Early diagnosis of colorectal cancer (CRC) simplifies treatment and improves treatment outcomes. We previously described a diagnostic metabolomic biomarker derived from semi-quantitative gas chromatography-mass spectrometry. Our objective was to determine whether a quantitative assay of additional metabolomic features, including parts of the lipidome could enhance diagnostic power; and whether there was an advantage to deriving a combined diagnostic signature with a broader metabolomic representation...
January 4, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29296211/global-lipidomics-identified-plasma-lipids-as-novel-biomarkers-for-early-detection-of-lung-cancer
#3
Zongtao Yu, Hankui Chen, Junmei Ai, Yong Zhu, Yan Li, Jeffrey A Borgia, Jin-Song Yang, Jicai Zhang, Bin Jiang, Wei Gu, Youping Deng
Purpose: Lipids play roles in membrane structure, energy storage, and signal transduction as well as in human cancers. Here we adopt lipidomics to identify plasma lipid markers for early screening and detection of lung cancer. Experimental Design: Using mass spectrometry, we profiled 390 individual lipids using training and validation strategy in a total of 346 plasma samples from 199 early NSCLC patients, including 113 adenocacinoma and 86 squamous cell cancers (SqCC), and from 147 healthy controls...
December 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/29290822/mir-31-5p-acox1-axis-enhances-tumorigenic-fitness-in-oral-squamous-cell-carcinoma-via-the-promigratory-prostaglandin-e2
#4
Yi-Hsuan Lai, Hsuan Liu, Wei-Fan Chiang, Ting-Wen Chen, Lichieh Julie Chu, Jau-Song Yu, Shu-Jen Chen, Hua-Chien Chen, Bertrand Chin-Ming Tan
During neoplastic development, a multitude of changes in genome-encoded information are progressively selected to confer growth and survival advantages to tumor cells. microRNAs-mRNAs regulatory networks, given their role as a critical layer of robust gene expression control, are frequently altered in neoplasm. However, whether and how these gene perturbations impact metabolic homeostasis remains largely unresolved. Methods: Through targeted miRNA expression screening, we uncovered an oral squamous cell carcinoma (OSCC)-associated miRNAome, among which miR-31-5p was identified based on extent of up-regulation, functional impact on OSCC cell migration and invasion, and direct regulation of the rate-limiting enzyme in peroxisomal β-oxidation, ACOX1...
2018: Theranostics
https://www.readbyqxmd.com/read/29277894/the-sphingosine-kinase-2-inhibitor-abc294640-displays-anti-non-small-cell-lung-cancer-activities-in-vitro-and-in-vivo
#5
Lu Dai, Charles D Smith, Maryam Foroozesh, Lucio Miele, Zhiqiang Qin
Non-small cell lung cancer (NSCLC) accounts for about 85-90% of lung cancer cases, and is the number one killer among cancers in the U.S. The majority of lung cancer patients do not respond well to conventional chemo- and/or radio-therapeutic regimens, and have a dismal 5-year survival rate of ∼15%. The recent introduction of targeted therapy and immunotherapy gives new hopes to NSCLC patients, but even with these agents, not all patients respond, and responses are rarely complete. Thus, there is still an urgent need to identify new therapeutic targets in NSCLC and develop novel anti-cancer agents...
December 26, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29274292/butyrate-and-docosahexaenoic-acid-interact-in-alterations-of-specific-lipid-classes-in-differentiating-colon-cancer-cells
#6
Zuzana Tylichová, Josef Slavík, Miroslav Ciganek, Petra Ovesná, Pavel Krčmář, Nicol Straková, Miroslav Machala, Alois Kozubík, Jiřina Hofmanová, Jan Vondráček
Docosahexaenoic acid (DHA) and sodium butyrate (NaBt) exhibit a number of interactive effects on colon cancer cell growth, differentiation or apoptosis; however, the molecular mechanisms responsible for these interactions and their impact on cellular lipidome are still not fully clear. Here, we show that both dietary agents together induce dynamic alterations of lipid metabolism, specific cellular lipid classes and fatty acid composition. In HT-29 cell line, a model of differentiating colon carcinoma cells, NaBt supported incorporation of free DHA into non-polar lipids and their accumulation in cytoplasmic lipid droplets...
December 23, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29232555/mtorc2-promotes-tumorigenesis-via-lipid-synthesis
#7
Yakir Guri, Marco Colombi, Eva Dazert, Sravanth K Hindupur, Jason Roszik, Suzette Moes, Paul Jenoe, Markus H Heim, Isabelle Riezman, Howard Riezman, Michael N Hall
Dysregulated mammalian target of rapamycin (mTOR) promotes cancer, but underlying mechanisms are poorly understood. We describe an mTOR-driven mouse model that displays hepatosteatosis progressing to hepatocellular carcinoma (HCC). Longitudinal proteomic, lipidomics, and metabolomic analyses revealed that hepatic mTORC2 promotes de novo fatty acid and lipid synthesis, leading to steatosis and tumor development. In particular, mTORC2 stimulated sphingolipid (glucosylceramide) and glycerophospholipid (cardiolipin) synthesis...
December 11, 2017: Cancer Cell
https://www.readbyqxmd.com/read/29229414/lipid-droplets-induced-by-secreted-phospholipase-a2and-unsaturated-fatty-acids-protect-breast-cancer-cells-from-nutrient-and-lipotoxic-stress
#8
Eva Jarc, Ana Kump, Petra Malavašič, Thomas O Eichmann, Robert Zimmermann, Toni Petan
Cancer cells driven by the Ras oncogene scavenge unsaturated fatty acids (FAs) from their environment to counter nutrient stress. The human group X secreted phospholipase A2(hGX sPLA2) releases FAs from membrane phospholipids, stimulates lipid droplet (LD) biogenesis in Ras-driven triple-negative breast cancer (TNBC) cells and enables their survival during starvation. Here we examined the role of LDs, induced by hGX sPLA2and unsaturated FAs, in protection of TNBC cells against nutrient stress. We found that hGX sPLA2releases a mixture of unsaturated FAs, including ω-3 and ω-6 polyunsaturated FAs (PUFAs), from TNBC cells...
December 8, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29211796/reprogramming-pancreatic-stellate-cells-via-p53-activation-a-putative-target-for-pancreatic-cancer-therapy
#9
Maya Saison-Ridinger, Kathleen E DelGiorno, Tejia Zhang, Annabelle Kraus, Randall French, Dawn Jaquish, Crystal Tsui, Galina Erikson, Benjamin T Spike, Maxim N Shokhirev, Christopher Liddle, Ruth T Yu, Michael Downes, Ronald M Evans, Alan Saghatelian, Andrew M Lowy, Geoffrey M Wahl
Pancreatic ductal adenocarcinoma (PDAC) is characterized by an extremely dense fibrotic stroma, which contributes to tumor growth, metastasis, and drug resistance. During tumorigenesis, quiescent pancreatic stellate cells (PSCs) are activated and become major contributors to fibrosis, by increasing growth factor signaling and extracellular matrix deposition. The p53 tumor suppressor is known to restrict tumor initiation and progression through cell autonomous mechanisms including apoptosis, cell cycle arrest, and senescence...
2017: PloS One
https://www.readbyqxmd.com/read/29209003/prostate-cancer-diagnosis-and-characterization-with-mass-spectrometry-imaging
#10
REVIEW
Annika Kurreck, Lindsey A Vandergrift, Taylor L Fuss, Piet Habbel, Nathalie Y R Agar, Leo L Cheng
BACKGROUND: Prostate cancer (PCa), the most common cancer and second leading cause of cancer death in American men, presents the clinical challenge of distinguishing between indolent and aggressive tumors for proper treatment. PCa presents significant alterations in metabolic pathways that can potentially be measured using techniques like mass spectrometry (MS) or MS imaging (MSI) and used to characterize PCa aggressiveness. MS quantifies metabolomic, proteomic, and lipidomic profiles of biological systems that can be further visualized for their spatial distributions through MSI...
December 5, 2017: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/29206907/a-novel-bioactive-derivative-of-eicosapentaenoic-acid-epa-suppresses-intestinal-tumor-development-in-apc%C3%AE-14-mice
#11
Masako Nakanishi, Matthew P Hanley, Ruochen Zha, Yuichi Igarashi, Mark A Hull, Gary Mathias, Frank Sciavolino, James J Grady, Daniel W Rosenberg
Familial adenomatous polyposis (FAP) is a genetic disorder characterized by the development of hundreds of polyps throughout the colon. Without prophylactic colectomy, most individuals with FAP develop colorectal cancer at an early age. Treatment with eicosapentaenoic acid (EPA) in the free fatty acid form (EPA-FFA) has been shown to reduce polyp burden in FAP patients. Since high-purity EPA-FFA is subject to rapid oxidation, a stable form of EPA compound has been developed in the form of magnesium l-lysinate bis-eicosapentaenoate (TP-252)...
December 1, 2017: Carcinogenesis
https://www.readbyqxmd.com/read/29191603/serum-lipid-profile-discriminates-patients-with-early-lung-cancer-from-healthy-controls
#12
Małgorzata Ros-Mazurczyk, Karol Jelonek, Michał Marczyk, Franciszek Binczyk, Monika Pietrowska, Joanna Polanska, Rafał Dziadziuszko, Jacek Jassem, Witold Rzyman, Piotr Widlak
OBJECTIVES: The role of a low-dose computed tomography lung cancer screening remains a matter of controversy due to its low specificity and high costs. Screening complementation with blood-based biomarkers may allow a more efficient pre-selection of candidates for imaging tests or discrimination between benign and malignant chest abnormalities detected by low-dose computed tomography (LD-CT). We searched for a molecular signature based on a serum lipid profile distinguishing individuals with early lung cancer from healthy participants of the lung cancer screening program...
October 2017: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/29182572/aberrant-lipid-metabolism-in-hepatocellular-carcinoma-revealed-by-liver-lipidomics
#13
Zhao Li, Ming Guan, Yu Lin, Xiao Cui, Yangyang Zhang, Zhenwen Zhao, Jiye Zhu
BACKGROUND: The aim of this study was to characterize the disorder of lipid metabolism in hepatocellular carcinoma (HCC). HCC is a worldwide disease. The research into the disorder of lipid metabolism in HCC is very limited. Study of lipid metabolism in liver cancer tissue may have the potential to provide new insight into HCC mechanisms. METHODS: A lipidomics study of HCC based on Ultra high performance liquid chromatography-electronic spray ionization-QTOF mass spectrometer (UPLC-ESI-QTOF MS) and Matrix assisted laser desorption ionization-fourier transform ion cyclotron resonance mass spectrometer (MALDI-FTICR MS) was performed...
November 28, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29168190/innovative-food-products-for-cancer-patients-future-directions
#14
Itziar Tueros, Matxalen Uriarte
One of the main challenges for cancer patients under treatment is to prevent and tackle malnutrition. The current clinical nutrition market offers different food supplements or oral nutritional support products (mainly milkshakes or modified texture products) for cancer patients under risk of malnutrition. However, it is worth mentioning, that these products do not address the pleasure of eating, since they do not meet sensory requirements, such as taste and smell alterations, nor patients' food preferences, leading to a big impact on their quality of life (QOL)...
November 23, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/29166560/analytical-challenges-and-recent-advances-in-mass-spectrometry-based-lipidomics
#15
Yepy H Rustam, Gavin E Reid
No abstract text is available yet for this article.
December 8, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/29037587/lipidomic-analysis-of-biological-samples-comparison-of-liquid-chromatography-supercritical-fluid-chromatography-and-direct-infusion-mass-spectrometry-methods
#16
Miroslav Lísa, Eva Cífková, Maria Khalikova, Magdaléna Ovčačíková, Michal Holčapek
Lipidomic analysis of biological samples in a clinical research represents challenging task for analytical methods given by the large number of samples and their extreme complexity. In this work, we compare direct infusion (DI) and chromatography - mass spectrometry (MS) lipidomic approaches represented by three analytical methods in terms of comprehensiveness, sample throughput, and validation results for the lipidomic analysis of biological samples represented by tumor tissue, surrounding normal tissue, plasma, and erythrocytes of kidney cancer patients...
October 8, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/29028617/a-plasma-lipidomics-strategy-reveals-perturbed-lipid-metabolic-pathways-and-potential-lipid-biomarkers-of-human-colorectal-cancer
#17
Sensen Shen, Li Yang, Linnan Li, Yu Bai, Chun Cai, Huwei Liu
To explore underlying molecular mechanisms and identify novel lipid biomarkers promising for colorectal cancer (CRC) diagnosis, a continuous-flow two dimensional liquid chromatography-quadrupole time-of-flight mass spectrometry (2D LC-QToF/MS) method was employed to comprehensively measure lipid species in human plasma of CRC patients and healthy controls. With a total of 427 annotated lipid species, we identified 64 lipid species with corrected p value less than 0.05 and fold change more than 1.5. These significantly altered lipid species were mainly involved in glycerolipids and glycerophospholipids metabolism and sphingolipids metabolism...
October 4, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28947740/group-iii-phospholipase-a2-promotes-colitis-and-colorectal-cancer
#18
Remi Murase, Yoshitaka Taketomi, Yoshimi Miki, Yasumasa Nishito, Moe Saito, Kiyoko Fukami, Kei Yamamoto, Makoto Murakami
Lipid mediators play pivotal roles in colorectal cancer and colitis, but only a limited member of the phospholipase A2 (PLA2) subtypes, which lie upstream of various lipid mediators, have been implicated in the positive or negative regulation of these diseases. Clinical and biochemical evidence suggests that secreted PLA2 group III (sPLA2-III) is associated with colorectal cancer, although its precise role remains obscure. Here we have found that sPLA2-III-null (Pla2g3 (-/-)) mice are highly resistant to colon carcinogenesis...
September 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28911967/applications-of-nuclear-magnetic-resonance-in-lipid-analyses-an-emerging-powerful-tool-for-lipidomics-studies
#19
REVIEW
Jingbo Li, Thomas Vosegaard, Zheng Guo
The role of lipids in cell, tissue, and organ physiology is crucial; as many diseases, including cancer, diabetes, neurodegenerative, and infectious diseases, are closely related to absorption and metabolism of lipids. Mass spectrometry (MS) based methods are the most developed powerful tools to study the synthetic pathways and metabolic networks of cellular lipids in biological systems; leading to the birth of an emerging subject lipidomics, which has been extensively reviewed. Nuclear magnetic resonance (NMR), another powerful analytical tool, which allows the visualization of single atoms and molecules, is receiving increasing attention in lipidomics analyses...
October 2017: Progress in Lipid Research
https://www.readbyqxmd.com/read/28894173/lipidomes-of-lung-cancer-and-tumour-free-lung-tissues-reveal-distinct-molecular-signatures-for-cancer-differentiation-age-inflammation-and-pulmonary-emphysema
#20
Lars F Eggers, Julia Müller, Chakravarthy Marella, Verena Scholz, Henrik Watz, Christian Kugler, Klaus F Rabe, Torsten Goldmann, Dominik Schwudke
Little is known about the human lung lipidome, its variability in different physiological states, its alterations during carcinogenesis and the development of pulmonary emphysema. We investigated how health status might be mirrored in the lung lipidome. Tissues were sampled for both lipidomic and histological analysis. Using a screening approach, we characterised lipidomes of lung cancer tissues and corresponding tumour-free alveolar tissues. We quantified 311 lipids from 11 classes in 43 tissue samples from 26 patients...
September 11, 2017: Scientific Reports
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