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Lipidomics and cancer

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https://www.readbyqxmd.com/read/28347999/lipin-1-regulation-of-phospholipid-synthesis-maintains-endoplasmic-reticulum-homeostasis-and-is-critical-for-triple-negative-breast-cancer-cell-survival
#1
Jingquan He, Feng Zhang, Li Wei Rachel Tay, Salome Boroda, Weiqi Nian, Kandice R Levental, Ilya Levental, Thurl E Harris, Jeffrey T Chang, Guangwei Du
Cancer cells reprogram their metabolism to increase the synthesis of macromolecules for rapid proliferation. Compared to fatty acids, much less is known about the synthesis of phospholipids, which is essential for membrane biogenesis in cancer cells. We found that LPIN1, which encodes lipin-1, a phosphatidic acid phosphatase (PAP) controlling the rate-limiting step in the phospholipid synthesis pathway, is highly up-regulated in basal-like triple-negative breast cancer (TNBC). Moreover, high LPIN1 expression correlates with the poor prognosis of these patients...
March 27, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28287094/enlightening-discriminative-network-functional-modules-behind-principal-component-analysis-separation-in-differential-omic-science-studies
#2
Sara Ciucci, Yan Ge, Claudio Durán, Alessandra Palladini, Víctor Jiménez-Jiménez, Luisa María Martínez-Sánchez, Yuting Wang, Susanne Sales, Andrej Shevchenko, Steven W Poser, Maik Herbig, Oliver Otto, Andreas Androutsellis-Theotokis, Jochen Guck, Mathias J Gerl, Carlo Vittorio Cannistraci
Omic science is rapidly growing and one of the most employed techniques to explore differential patterns in omic datasets is principal component analysis (PCA). However, a method to enlighten the network of omic features that mostly contribute to the sample separation obtained by PCA is missing. An alternative is to build correlation networks between univariately-selected significant omic features, but this neglects the multivariate unsupervised feature compression responsible for the PCA sample segregation...
March 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28257116/valorization-of-lipids-from-gracilaria-sp-through-lipidomics-and-decoding-of-antiproliferative-and-anti-inflammatory-activity
#3
Elisabete da Costa, Tânia Melo, Ana S P Moreira, Carina Bernardo, Luisa Helguero, Isabel Ferreira, Maria Teresa Cruz, Andreia M Rego, Pedro Domingues, Ricardo Calado, Maria H Abreu, Maria Rosário Domingues
The lipidome of the red seaweed Gracilaria sp., cultivated on land-based integrated multitrophic aquaculture (IMTA) system, was assessed for the first time using hydrophilic interaction liquid chromatography-mass spectrometry and tandem mass spectrometry (HILIC-MS and MS/MS). One hundred and forty-seven molecular species were identified in the lipidome of the Gracilaria genus and distributed between the glycolipids classes monogalactosyl diacylglyceride (MGDG), digalactosyl diacylglyceride (DGDG), sulfoquinovosyl monoacylglyceride (SQMG), sulfoquinovosyl diacylglyceride (SQDG), the phospholipids phosphatidylcholine (PC), lyso-PC, phosphatidylglycerol (PG), lyso-PG, phosphatidylinositol (PI), phosphatidylethanolamine (PE), phosphatic acid (PA), inositolphosphoceramide (IPC), and betaine lipids monoacylglyceryl- and diacylglyceryl-N,N,N-trimethyl homoserine (MGTS and DGTS)...
March 2, 2017: Marine Drugs
https://www.readbyqxmd.com/read/28248089/mapping-novel-metabolic-nodes-targeted-by-anti-cancer-drugs-that-impair-triple-negative-breast-cancer-pathogenicity
#4
Lindsay S Roberts, Peter Yan, Leslie A Bateman, Daniel K Nomura
Triple-negative breast cancers (TNBCs) are estrogen receptor, progesterone receptor, and HER2 receptor-negative subtypes of breast cancers that show the worst prognoses and lack targeted therapies. Here, we have coupled the screening of ∼400 anticancer agents that are under development or in the clinic with chemoproteomic and metabolomic profiling to identify novel metabolic mechanisms for agents that impair TNBC pathogenicity. We identify 20 anticancer compounds that significantly impaired cell survival across multiple types of TNBC cells...
March 8, 2017: ACS Chemical Biology
https://www.readbyqxmd.com/read/28207743/lipidomic-approach-for-stratification-of-acute-myeloid-leukemia-patients
#5
Adam Stefanko, Christian Thiede, Gerhard Ehninger, Kai Simons, Michal Grzybek
The pathogenesis and progression of many tumors, including hematologic malignancies is highly dependent on enhanced lipogenesis. De novo fatty-acid synthesis permits accelerated proliferation of tumor cells by providing membrane components but these may also alter physicochemical properties of lipid bilayers, which can impact signaling or even increase drug resistance in cancer cells. Cancer type-specific lipid profiles would permit us to monitor and interpret actual effects of lipid changes, potential fingerprints of individual tumors to be explored as diagnostic markers...
2017: PloS One
https://www.readbyqxmd.com/read/28192938/size-dependent-lipidomic-analysis-of-urinary-exosomes-from-patients-with-prostate-cancer-by-flow-field-flow-fractionation-and-nanoflow-liquid-chromatography-tandem-mass-spectrometry
#6
Joon Seon Yang, Jong Cheol Lee, Seul Kee Byeon, Koon Ho Rha, Myeong Hee Moon
Exosomes are membrane-bound extracellular vesicles involved in intercellular communication and tumor cell metastasis. In this study, flow field-flow fractionation (FlFFF) was utilized to separate urinary exosomes by size, demonstrating a significant difference in exosome sizes between healthy controls and patients with prostate cancer (PCa). Exosome fractions of different sizes were collected for microscopic analysis during an FlFFF run and evaluated with exosome marker proteins using Western blot analysis...
February 2, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28185575/integration-of-metabolomics-lipidomics-and-clinical-data-using-a-machine-learning-method
#7
Animesh Acharjee, Zsuzsanna Ament, James A West, Elizabeth Stanley, Julian L Griffin
BACKGROUND: The recent pandemic of obesity and the metabolic syndrome (MetS) has led to the realisation that new drug targets are needed to either reduce obesity or the subsequent pathophysiological consequences associated with excess weight gain. Certain nuclear hormone receptors (NRs) play a pivotal role in lipid and carbohydrate metabolism and have been highlighted as potential treatments for obesity. This realisation started a search for NR agonists in order to understand and successfully treat MetS and associated conditions such as insulin resistance, dyslipidaemia, hypertension, hypertriglyceridemia, obesity and cardiovascular disease...
November 22, 2016: BMC Bioinformatics
https://www.readbyqxmd.com/read/28138993/arachidonic-acid-containing-phosphatidylcholine-characterized-by-consolidated-plasma-and-liver-lipidomics-as-an-early-onset-marker-for-tamoxifen-induced-hepatic-phospholipidosis
#8
Kosuke Saito, Keisuke Goda, Akio Kobayashi, Naohito Yamada, Kyoko Maekawa, Yoshiro Saito, Shoichiro Sugai
Lipid profiling has emerged as an effective approach to not only screen disease and drug toxicity biomarkers but also understand their underlying mechanisms of action. Tamoxifen, a widely used antiestrogenic agent for adjuvant therapy against estrogen-positive breast cancer, possesses side effects such as hepatic steatosis and phospholipidosis (PLD). In the present study, we administered tamoxifen to Sprague-Dawley rats and used lipidomics to reveal tamoxifen-induced alteration of the hepatic lipid profile and its association with the plasma lipid profile...
January 31, 2017: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/28132185/spatial-metabolite-profiling-by-matrix-assisted-laser-desorption-ionization-mass-spectrometry-imaging
#9
Berin A Boughton, Brett Hamilton
Mass spectrometry imaging (MSI) is rapidly maturing as an advanced method for spatial metabolite profiling. Herein, we provide an introduction to MSI including types of instrumentation, detailed sample preparation, data collection, overview of data analysis steps, software, common standards, and new developments. Further, we provide an overview of MSI in the clinical space over the past 3 years where MSI has been deployed in diverse research areas including cancer, neurobiology, lipidomics, and metabolite profiling and mapping to name only a few...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28110652/ambient-mass-spectrometry-in-cancer-research
#10
Z Takats, N Strittmatter, J S McKenzie
Ambient ionization mass spectrometry was developed as a sample preparation-free alternative to traditional MS-based workflows. Desorption electrospray ionization (DESI)-MS methods were demonstrated to allow the direct analysis of a broad range of samples including unaltered biological tissue specimens. In contrast to this advantageous feature, nowadays DESI-MS is almost exclusively used for sample preparation intensive mass spectrometric imaging (MSI) in the area of cancer research. As an alternative to MALDI, DESI-MSI offers matrix deposition-free experiment with improved signal in the lower (<500m/z) range...
2017: Advances in Cancer Research
https://www.readbyqxmd.com/read/28106223/next-generation-of-network-medicine-interdisciplinary-signaling-approaches
#11
REVIEW
Tamas Korcsmaros, Maria Victoria Schneider, Giulio Superti-Furga
In the last decade, network approaches have transformed our understanding of biological systems. Network analyses and visualizations have allowed us to identify essential molecules and modules in biological systems, and improved our understanding of how changes in cellular processes can lead to complex diseases, such as cancer, infectious and neurodegenerative diseases. "Network medicine" involves unbiased large-scale network-based analyses of diverse data describing interactions between genes, diseases, phenotypes, drug targets, drug transport, drug side-effects, disease trajectories and more...
February 20, 2017: Integrative Biology: Quantitative Biosciences From Nano to Macro
https://www.readbyqxmd.com/read/28073184/functional-lipidomics-palmitic-acid-impairs-hepatocellular-carcinoma-development-by-modulating-membrane-fluidity-and-glucose-metabolism
#12
Ling Lin, Ying Ding, Yi Wang, Zhenxin Wang, Xuefei Yin, Guoquan Yan, Lei Zhang, Pengyuan Yang, Huali Shen
Lipids are essential cellular components and energy sources of living organisms, altered lipid composition is increasingly recognized as a signature of cancer. We performed the lipidomic analysis in a series of hepatocellular carcinoma (HCC) cells and identified over 1700 intact lipids originating from 3 major lipid categories. Comparative lipidomic screening revealed 93 significantly changed lipids and decreased palmitic acyl (C16:0)-containing glycerophospholipids (GPs) were positively associated with metastatic abilities of HCC cells...
January 10, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/27992229/comprehensive-metabolomic-and-lipidomic-profiling-of-human-kidney-tissue-a-platform-comparison
#13
Patrick Leuthold, Elke Schaeffeler, Stefan Winter, Florian Büttner, Ute Hofmann, Thomas E Mürdter, Steffen Rausch, Denise Sonntag, Judith Wahrheit, Falko Fend, Jörg Hennenlotter, Jens Bedke, Matthias Schwab, Mathias Haag
Metabolite profiling of tissue samples is a promising approach for the characterization of cancer pathways and tumor classification based on metabolic features. Here, we present an analytical method for nontargeted metabolomics of kidney tissue. Capitalizing on different chemical properties of metabolites allowed us to extract a broad range of molecules covering small polar molecules and less polar lipid classes that were analyzed by LC-QTOF-MS after HILIC and RP chromatographic separation, respectively. More than 1000 features could be reproducibly extracted and analyzed (CV < 30%) in porcine and human kidney tissue, which were used as surrogate matrices for method development...
January 12, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/27956048/omental-adipocytes-enhance-the-invasiveness-of-gastric-cancer-cells-by-oleic-acid-induced-activation-of-the-pi3k-akt-signaling-pathway
#14
Fan Xiang, Ke Wu, Yulin Liu, Liang Shi, Di Wang, Gang Li, Kaixiong Tao, Guobin Wang
A considerable number of patients with advanced gastric cancer have a clear predilection for metastasis to the great omentum, an organ mainly composed of adipose tissue. However, it remains unclear why tumor cells preferentially spread to and progress in the omentum. Here, we used a two-dimensional co-culture system to simulate the crosstalk between adipocytes and gastric cancer cells and showed that after co-culture with isolated omental adipocytes, gastric cancer cells exhibited a significant increase in lipid uptake and enhanced invasiveness...
December 9, 2016: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/27936316/bioprospecting-of-turbinaria-macroalgae-as-a-potential-source-of-health-protective-compounds
#15
Milena Stranska-Zachariasova, Isma Kurniatanty, Helena Gbelcova, Monika Jiru, Josep Rubert, Tjokorda Gde Tirta Nindhia, Cosimo Walter D'Acunto, Sony Heru Sumarsono, Marselina Irasonia Tan, Jana Hajslova, Tomas Ruml
The present study aims to focus on the bioprospecting of marine macroalgae of Turbinaria species, plenteous biomass of the world ocean. Three types of solvents, i.e., H2 O, MeOH/H2 O (80:20, v/v) and hexane/i-PrOH (50:50, v/v), were used for extraction. Both the biological activity and the pattern of present chemicals were characterized. For the cell proliferation assay, the human embryonic kidney 293 cells, cervix/breast/pancreatic adenocarcinoma, and osteosarcoma cells were used. For the antioxidant activity determination, both intracellular assay with human embryonic kidney and cervix adenocarcinoma cells, as well as the biochemical DPPH test, were employed...
February 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/27916803/advances-in-lipidomics-for-cancer-biomarkers-discovery
#16
REVIEW
Francesca Perrotti, Consuelo Rosa, Ilaria Cicalini, Paolo Sacchetta, Piero Del Boccio, Domenico Genovesi, Damiana Pieragostino
Lipids play critical functions in cellular survival, proliferation, interaction and death, since they are involved in chemical-energy storage, cellular signaling, cell membranes, and cell-cell interactions. These cellular processes are strongly related to carcinogenesis pathways, particularly to transformation, progression, and metastasis, suggesting the bioactive lipids are mediators of a number of oncogenic processes. The current review gives a synopsis of a lipidomic approach in tumor characterization; we provide an overview on potential lipid biomarkers in the oncology field and on the principal lipidomic methodologies applied...
November 28, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27915214/recent-advances-in-expanding-the-coverage-of-the-lipidome
#17
REVIEW
Sergey Tumanov, Jurre J Kamphorst
The lipidome comprises a large array of molecules with diverse physicochemical properties. Lipids are structural components of cells, act as a source of energy, and function as signaling mediators. Alterations in lipid metabolism are involved in the onset and progression of a variety of diseases, including metabolic syndrome and cancer. Because of this, interest in lipidomics, the comprehensive characterization of the lipidome by mass spectrometry, has intensified in recent years. However, obtaining a truly complete overview of all lipids in a sample has remained very challenging due to their enormous structural diversity...
February 2017: Current Opinion in Biotechnology
https://www.readbyqxmd.com/read/27914242/molecular-lipid-species-in-urinary-exosomes-as-potential-prostate-cancer-biomarkers
#18
Tore Skotland, Kim Ekroos, Dimple Kauhanen, Helena Simolin, Therese Seierstad, Viktor Berge, Kirsten Sandvig, Alicia Llorente
BACKGROUND: Exosomes have recently appeared as a novel source of noninvasive cancer biomarkers, since these nanovesicles contain molecules from cancer cells and can be detected in biofluids. We have here investigated the potential use of lipids in urinary exosomes as prostate cancer biomarkers. METHODS: A high-throughput mass spectrometry quantitative lipidomic analysis was performed to reveal the lipid composition of urinary exosomes in prostate cancer patients and healthy controls...
January 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/27893427/cholesterol-import-and-steroidogenesis-are-biosignatures-for-gastric-cancer-patient-survival
#19
Wei-Chun Chang, Shang-Fen Huang, Yang-Ming Lee, Hsueh-Chou Lai, Bi-Hua Cheng, Wei-Chung Cheng, Jason Yen-Ping Ho, Long-Bin Jeng, Wen-Lung Ma
Androgens, estrogens, progesterone and related signals are reported to be involved in the pathology of gastric cancer. However, varied conclusions exist based on serum hormone levels, receptor expressions, and in vitro or in vivo studies. This report used a web-based gene survival analyzer to evaluate biochemical processes, including cholesterol importing via lipoprotein/receptors (L/R route), steroidogenic enzymes, and steroid receptors, in gastric cancer patients prognosis. The sex hormone receptors (androgen receptor, progesterone receptor, and estrogen receptor ESR1 or ESR2), L/R route (low/high-density lipoprotein receptors, LDLR/LRP6/SR-B1 and lipoprotein lipase, LPL) and steroidogenic enzymes (CYP11A1, HSD3B1, CYP17, HSD17B1, HSD3B1, CYP19A1 and SRD5A1) were associated with 5-year survival of gastric cancer patients...
January 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/27889637/cell-membrane-modulation-as-adjuvant-in-cancer-therapy
#20
REVIEW
Sara Zalba, Timo L M Ten Hagen
Cancer is a complex disease involving numerous biological processes, which can exist in parallel, can be complementary, or are engaged when needed and as such can replace each other. This redundancy in possibilities cancer cells have, are fundamental to failure of therapy. However, intrinsic features of tumor cells and tumors as a whole provide also opportunities for therapy. Here we discuss the unique and specific makeup and arrangement of cell membranes of tumor cells and how these may help treatment. Interestingly, knowledge on cell membranes and associated structures is present already for decades, while application of membrane modification and manipulation as part of cancer therapy is lagging...
January 2017: Cancer Treatment Reviews
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