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JOURNAL ARTICLE
Timm Ubben, Christian Frerker, Buntaro Fujita, Stephan Rosenkranz, Roman Pfister, Stephan Baldus, Hannes Alessandrini, Karl-Heinz Kuck, Stephan Willems, Ingo Eitel, Tobias Schmidt
OBJECTIVES: The association of pulmonary hypertension (PH) with the outcome after mitral transcatheter edge-to-edge repair (M-TEER) focusing on the new ESC/ERS guidelines definition for PH. BACKGROUND: PH is frequently found in patients with mitral regurgitation and is associated with lower survival rates. Recent studies were based on echocardiographic parameters, but results based on invasive haemodynamics differentiating distinct types of PH using the new definition for PH are missing...
February 22, 2024: Heart
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JOURNAL ARTICLE
Espen Holte, Tomaž Podlesnikar, Fontes Carvalho, Ahmet Demirkiran, Robert Manka, Gabriela Guzmán Martínez, Błażej Michalski J, Agnès Pasquet Separovic, Hatem Soliman-Aboumarie, Joshi Shruti S, Kristina H Haugaa, Marc R Dweck
AIMS: To evaluate the diagnosis and imaging of patients with mitral regurgitation and the management in routine clinical practice across Europe, the EACVI Scientific Initiatives Committee performed a survey across European centres. In particular, the routine use of echocardiography, advanced imaging modalities, heart valve clinics and heart valve teams was explored. METHODS AND RESULTS: A total of 61 responders, mainly tertiary centres or university hospitals, from 26 different countries responded to the survey, which consisted of 22 questions...
February 22, 2024: European Heart Journal Cardiovascular Imaging
#23
REVIEW
Federico Vancheri, Giovanni Longo, Michael Y Henein
Risk stratification of cardiovascular death and treatment strategies in patients with heart failure (HF), the optimal timing for valve replacement, and the selection of patients for implantable cardioverter defibrillators are based on an echocardiographic calculation of left ventricular ejection fraction (LVEF) in most guidelines. As a marker of systolic function, LVEF has important limitations being affected by loading conditions and cavity geometry, as well as image quality, thus impacting inter- and intra-observer measurement variability...
2024: Frontiers in Cardiovascular Medicine
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JOURNAL ARTICLE
Julien Dreyfus, Monika Komar, David Attias, Michele De Bonis, Frank Ruschitzka, Bogdan A Popescu, Cécile Laroche, Christophe Tribouilloy, Alexander Bogachev Prokophiev, Vaida Mizariene, Jeroen J Bax, Aldo Pietro Maggioni, David Messika-Zeitoun, Alec Vahanian, Bernard Iung
AIMS: Tricuspid regurgitation (TR) is commonly observed in patients with severe left-sided valvular heart disease (VHD). This study sought to assess TR frequency, management and outcome in this population. METHODS AND RESULTS: Among 6883 patients with severe native left-sided VHD or previous left-sided valvular intervention enrolled in the EURObservational Research Programme prospective VHD II survey, moderate or severe TR was very frequent in patients with severe mitral VHD (30% when mitral stenosis, 36% when mitral regurgitation [MR]), especially in patients with secondary MR (46%), and rare in patients with severe aortic VHD (4% when aortic stenosis, 3% when aortic regurgitation)...
February 19, 2024: European Journal of Heart Failure
#25
JOURNAL ARTICLE
Karl-Patrik Kresoja, Marianna Adamo, Karl-Phillipp Rommel, Lukas Stolz, Nicole Karam, Cristina Giannini, Bruno Melica, Ralph Stephan von Bardeleben, Christian Butter, Patrick Horn, Fabien Praz, Daniel Kalbacher, Christos Iliadis, Holger Thiele, Jörg Hausleiter, Marco Metra, Philipp Lurz
AIMS: Achieving optimized guideline-directed medical therapy (GDMT) is recommended prior to transcatheter mitral valve edge-to-edge repair (M-TEER) for secondary mitral regurgitation (SMR). We aimed to propose and validate an easy-to-use score for assessing the quality of GDMT in patients with heart failure with reduced ejection fraction (HFrEF) undergoing M-TEER. METHODS AND RESULTS: Among the 1641 EuroSMR patients enrolled in the EuroSMR Registry who underwent M-TEER, a total of 1072 patients [median age 74, interquartile range (IQR) 67-79 years, 29% female] had complete data on GDMT and a left ventricular ejection fraction ≤ 40% and were included in the current study...
February 13, 2024: ESC Heart Failure
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Karthic Chandran, Donald Quimby, Hiram G Bezerra, Daniela Crousillat
BACKGROUND: Prior exposure to cardiotoxic cancer therapies has been associated with an increased risk of peripartum cardiomyopathy (PPCM). The management of PPCM in this population remains a clinical challenge. Few studies have explored the use of mechanical circulatory support in PPCM. We present a case of early implementation of intra-aortic balloon pump (IABP) therapy for acute stabilization and intrapartum support of PPCM. CASE SUMMARY: A 36-year-old G4P2103 (4th pregnancy, two full-term, one premature birth, 0 abortions, and three living children) woman at 26 weeks and 5 days gestation with history of combined peripartum and anthracycline-induced cardiomyopathy [previously left ventricular ejection fraction (LVEF) 10-15% and recently 40-45%] presented with acute decompensated heart failure...
February 2024: European Heart Journal. Case Reports
#27
REVIEW
Despina-Manuela Toader
Mitral regurgitation is among the most common valvular heart diseases. Mitral regurgitation in patients with dilated cardiomyopathy is a complex pathology involving annular dilatation, papillary muscle displacement, systolic leaflet tethering, and left ventricular remodeling. Quantification of mitral apparatus damage in these patients is essential for successful interventional and surgical therapy. Mitral regurgitation in the presence of dilated cardiomyopathy is classified as Carpentier type IIIB, with restricted leaflet mobility as a standard feature...
February 2024: Journal of International Medical Research
#28
REVIEW
Moving from left ventricular ejection fraction to deformation imaging in mitral valve regurgitation.
Stylianos Daios, Vasileios Anastasiou, Maria-Anna Bazmpani, Stella-Maria Angelopoulou, Theodoros Karamitsos, Thomas Zegkos, Matthaios Didagelos, Christos Savopoulos, Antonios Ziakas, Vasileios Kamperidis
The increasing prevalence of valvular heart diseases, specifically mitral regurgitation (MR), underscores the need for a careful and timely approach to intervention. Severe MR, whether primary or secondary, when left untreated leads to adverse outcomes, emphasizing the critical role of a timely surgical or transcatheter intervention. While left ventricular ejection fraction (LVEF) remains the guideline-recommended measure for assessing left ventricle damage, emerging evidence raises concerns regarding its reliability in MR due to its volume-dependent nature...
April 2024: Current Problems in Cardiology
#29
REVIEW
Iva Minga, Esther Kwak, Kifah Hussain, Lucas Wathen, Safwan Gaznabi, Lavisha Singh, Victor Macrinici, Chi-Hsiung Wang, Cristine Singulane, Karima Addetia, Nitasha Sarswat, Jeremy Slivnick, Amit Pursnani
BACKGROUND: Limited data exists on the prognostic impact of valvular heart disease in cardiac amyloidosis (CA). We therefore sought to define the prevalence of valvular disease in patients with CA and assess the effects of significant valve disease on survival. METHODS: This multi-center retrospective cohort study included consecutive patients with confirmed transthyretin (TTR) or light chain (AL) amyloidosis. Echocardiographic data closest to the date of amyloid diagnosis was reviewed, and severity was graded according to ASE guidelines...
January 25, 2024: Current Problems in Cardiology
#30
REVIEW
William A Zoghbi, Pei-Ni Jone, Mohammed A Chamsi-Pasha, Tiffany Chen, Keith A Collins, Milind Y Desai, Paul Grayburn, Daniel W Groves, Rebecca T Hahn, Stephen H Little, Eric Kruse, Danita Sanborn, Sangeeta B Shah, Lissa Sugeng, Madhav Swaminathan, Jeremy Thaden, Paaladinesh Thavendiranathan, Wendy Tsang, Jonathan R Weir-McCall, Edward Gill
In patients with significant cardiac valvular disease, intervention with either valve repair or valve replacement may be inevitable. Although valve repair is frequently performed, especially for mitral and tricuspid regurgitation, valve replacement remains common, particularly in adults. Diagnostic methods are often needed to assess the function of the prosthesis. Echocardiography is the first-line method for noninvasive evaluation of prosthetic valve function. The transthoracic approach is complemented with two-dimensional and three-dimensional transesophageal echocardiography for further refinement of valve morphology and function when needed...
January 2024: Journal of the American Society of Echocardiography
#31
JOURNAL ARTICLE
Firezer Haregu, Ningyan Wong, Michael McCulloch, D Scott Lim
Rigorous clinical trials have demonstrated the safety and efficacy of Transcatheter Edge-to-Edge Repair to treat severe secondary mitral regurgitation (MR) in adults with primary cardiomyopathy who have failed guideline-directed medical therapy, as well as those with primary MR at high surgical risk. To date, there are only three case reports describing this procedure in the pediatric population. We report a case series of four pediatric patients, including the youngest and smallest reported, who underwent this procedure...
December 27, 2023: Pediatric Cardiology
#32
JOURNAL ARTICLE
Jiangtao Li, Xiang Wei
OBJECTIVES: A novel transapical beating-heart septal myectomy (TA-BSM) procedure was performed for patients with latent obstruction through the left intercostal incision and without cardiopulmonary bypass. This study aims to demonstrate the experience of the TA-BSM procedure for patients with latent obstruction and compare outcomes to patients with resting obstruction. METHODS: We studied 120 symptomatic hypertrophic obstructive cardiomyopathy patients (33 with latent obstruction and 87 with resting obstruction) who underwent TA-BSM...
December 19, 2023: European Journal of Cardio-thoracic Surgery
#33
JOURNAL ARTICLE
Leo Marcoff, Konstantinos Koulogiannis, Lilian Aldaia, Anuj Mediratta, Scott M Chadderdon, Moody M Makar, Tobias Friedrich Ruf, Theresa Gößler, Jonathan G Zaroff, Gordon K Leung, Ivy A Ku, Michael Nabauer, Paul A Grayburn, Zuyue Wang, Katie M Hawthorne, Dale E Fowler, Jacob P Dal-Bianco, Mani A Vannan, Carmine Bevilacqua, Massimiliano Meineri, Joerg Ender, Anna Flo Forner, Jyothy J Puthumana, Atizazul Hassan Mansoor, Dustin J Lloyd, Steven J Voskanian, Andrew Ghobrial, Rebecca T Hahn, Feroze Mahmood, Christiane Haeffele, Geraldine Ong, Leonhard Moritz Schneider, Dee Dee Wang, Nishant K Sekaran, Elana Koss, Priti Mehla, Serge Harb, Rhonda Miyasaka, Maria Ivannikova, Terri Stewart-Dehner, Lucas Mitchel, Sasan R Raissi, Daniel Kalbacher, Santanu Biswas, Edwin C Ho, Ythan Goldberg, Robert L Smith, Jörg Hausleiter, D Scott Lim, Linda D Gillam
BACKGROUND: The CLASP IID randomized trial (Edwards PASCAL TrAnScatheter Valve RePair System Pivotal Clinical Trial; NCT03706833) demonstrated the safety and effectiveness of the PASCAL system for mitral transcatheter edge-to-edge repair (M-TEER) in patients at prohibitive surgical risk with significant symptomatic degenerative mitral regurgitation (DMR). OBJECTIVES: This study describes the echocardiographic methods and outcomes from the CLASP IID trial and analyzes baseline variables associated with residual mitral regurgitation (MR) ≤1+...
December 1, 2023: JACC. Cardiovascular Imaging
#34
REVIEW
Jasper Iske, Maximilian J Roesel, Nikola Cesarovic, Leonard Pitts, Annabel Steiner, Leonard Knoedler, Timo Z Nazari-Shafti, Serdar Akansel, Stephan Jacobs, Volkmar Falk, Joerg Kempfert, Markus Kofler
Mitral valve prolapse (MVP) is common among heart valve disease patients, causing severe mitral regurgitation (MR). Although complications such as cardiac arrhythmias and sudden cardiac death are rare, the high prevalence of the condition leads to a significant number of such events. Through next-generation gene sequencing approaches, predisposing genetic components have been shown to play a crucial role in the development of MVP. After the discovery of the X-linked inheritance of filamin A, autosomal inherited genes were identified...
November 30, 2023: Journal of Clinical Medicine
#35
JOURNAL ARTICLE
Maximilian Spieker, Sidabras Jonas, Hannah Lagarden, Lucas Christian, Stephan Angendohr, Elric Zweck, Alex Bejinariu, Verena Veulemanns, Christian Schulze, Amin Polzin, Obaida Rana, Ralf Westenfeld, Malte Kelm, Patrick Horn
AIMS: In atrial functional mitral regurgitation (aFMR), a considerable proportion of patients displays a discrepancy between symptoms and echocardiographic findings at rest. Exercise testing plays a substantial role in assessing the haemodynamic relevance of mitral regurgitation (MR) and is recommended by current guidelines. Here, we aimed to assess the prevalence, extent, and prognostic impact of exercise-induced changes in patients with aFMR. METHODS AND RESULTS: Patients with at least mild MR who underwent handgrip exercise echocardiography at the University Hospital Duesseldorf between January 2019 and September 2021 were enrolled...
December 8, 2023: European Heart Journal Cardiovascular Imaging
#36
JOURNAL ARTICLE
Augustin Coisne, Andrea Scotti, Juan F Granada, Paul A Grayburn, Michael J Mack, David J Cohen, Saibal Kar, D Scott Lim, JoAnn Lindenfeld, Jeroen Bax, Lak N Kotinkaduwa, Björn Redfors, Neil J Weissman, Federico M Asch, Gregg W Stone
AIMS: The conceptual framework of proportionate versus disproportionate mitral regurgitation (MR) translates poorly to individual patients with heart failure (HF) and secondary MR. A novel index, the ratio of MR severity to left atrial volume (LAV), may identify patients with "disproportionate" MR and a higher risk of events. The objectives, therefore, were to investigate the prognostic impact of MR severity to LAV ratio on outcomes among HF patients with severe secondary MR randomized to transcatheter edge-to-edge repair (TEER) with the MitraClipTM device plus guideline-directed medical therapy (GDMT) vs...
December 7, 2023: European Heart Journal Cardiovascular Imaging
#37
REVIEW
Jacqueline H Fortier, Yashaswi Thapa, Andrew M Crean, Himanshu Gupta, Juan B Grau
For patients with hypertrophic cardiomyopathy (HCM), a thickened intraventricular septum and systolic anterior motion of the mitral valve (SAM) can contribute to significant left ventricular outflow tract obstruction, mitral regurgitation, and debilitating symptoms. Current guidelines recommend septal reduction therapy through alcohol septal ablation or surgical septal myectomy for patients whose symptoms persist despite medical therapy. While alcohol septal ablation is a less invasive treatment option, it is not suitable for patients with septal perforator branch anatomy that is not compatible with the procedure, those with midcavitary obstruction, and patients in whom the mechanism of LVOTO is primarily related to SAM...
December 3, 2023: Canadian Journal of Cardiology
#38
Filip Depta, Martin Pažitný, Michal Trebišovský, Tatiana Maďarová, Jana Deptová
BACKGROUND: Paenibacillus constitutes a genus of gram-positive, facultatively anaerobic, rod-shaped bacteria that act as potentially opportunistic pathogens. With only a few documented case studies to date, Paenibacillus species are rarely the cause of a disease in humans. CASE SUMMARY: We report a case involving a 64-year-old male with known mild mitral regurgitation, who presented with fever and dyspnoea. Initially treated with empirical antibiotics, his blood cultures cultivated Paenibacillus thiaminolyticus , a previously unreported cause of endocarditis...
November 2023: European Heart Journal. Case Reports
#39
REVIEW
Bansi Patel, Steve D'Souza, Tamanna Sahni, Amin Yehya
Pulmonary hypertension (PH) is a common disease affecting up to 1% of the population and at least 50% of patients diagnosed with heart failure (HF) (Hoeper et al. in Lancet Respir Med 4(4):306-322, 2016). It is estimated that PH is present in 15% to 60% of patients with valvular heart disease (VHD) which can result from an increase in pulmonary blood flow and subsequently in pulmonary venous congestion and pulmonary vascular resistance (PVR). It is important to identify the severity of PH in patients with VHD to appropriately risk stratify and manage these patients (Magne et al...
November 29, 2023: Heart Failure Reviews
#40
JOURNAL ARTICLE
David Leibowitz, Donna Zwas, Ronen Beeri, Ronny Alcalai, Israel Gotsman
BACKGROUND: Chronic mitral regurgitation (MR) is a volume overload state that causes dilatation of the left sided cardiac chambers. The presence of significant dilatation is considered an indication for mitral valve intervention, however, aging may affect left ventricular (LV) remodeling independently of valvular disease. The objective of this study was to examine age-related changes in cardiac remodeling in a broad population of patients with chronic MR. METHODS: Consecutive subjects that underwent echocardiography examinations recorded in the echocardiography database of a university-affiliated laboratory were retrieved...
October 28, 2023: Journal of Geriatric Cardiology: JGC
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