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https://www.readbyqxmd.com/read/28336397/soluble-endoglin-modulates-the-pro-inflammatory-mediators-nf-%C3%AE%C2%BAb-and-il-6-in-cultured-human-endothelial-cells
#1
Michala Varejckova, Eunate Gallardo-Vara, Matej Vicen, Barbora Vitverova, Petra Fikrova, Eva Dolezelova, Jana Rathouska, Alena Prasnicka, Katerina Blazickova, Stanislav Micuda, Carmelo Bernabeu, Ivana Nemeckova, Petr Nachtigal
AIMS: Endoglin is a transmembrane glycoprotein, that plays an important role in regulating endothelium. Proteolytic cleavage of membrane endoglin releases soluble endoglin (sEng), whose increased plasma levels have been detected in diseases related to the cardiovascular system. It was proposed that sEng might damage vascular endothelium, but detailed information about the potential mechanisms involved is not available. Thus, we hypothesized that sEng contributes to endothelial dysfunction, leading to a pro-inflammatory phenotype by a possible modulation of the TGF-β and/or inflammatory pathways...
March 20, 2017: Life Sciences
https://www.readbyqxmd.com/read/28288784/development-and-validation-of-a-measurement-procedure-based-on-ultra-high-performance-liquid-chromatography-tandem-mass-spectrometry-for-simultaneous-measurement-of-%C3%AE-lactam-antibiotic-concentration-in-human-plasma
#2
Raül Rigo-Bonnin, Alba Ribera, Ariadna Arbiol-Roca, Sara Cobo-Sacristán, Ariadna Padullés, Òscar Murillo, Evelyn Shaw, Rosa Granada, Xosé L Pérez-Fernández, Fe Tubau, Pedro Alía
BACKGROUND: The administration of β-lactam antibiotics in continuous infusion could let optimize the pharmacokinetic/pharmacodynamic parameters, especially in the treatment of serious bacterial infections. In this context, and also due to variability in their plasmatic concentrations, therapeutic drug monitoring (TDM) may be useful to optimize dosing and, therefore, be useful for the clinicians. MATERIAL AND METHODS: We developed and validated a measurement procedure based on ultra-high performance liquid chromatography-tandem mass spectrometry for simultaneous measurement of amoxicillin, ampicillin, cloxacillin, piperacillin, cefepime, ceftazidime, cefuroxime, aztreonam and meropenem concentrations in plasma...
March 10, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28208103/caring-for-children-with-intellectual-disabilities-part-1-experience-with-the-population-pain-related-beliefs-and-care-decisions
#3
Lara M Genik, C Meghan McMurtry, Lynn M Breau
Some children with intellectual disabilities (ID): experience pain more frequently than children without ID, express their pain differently, and are incapable of providing self-reports. No research has examined disability and pain-related beliefs of respite workers (RW) and their relations to pain assessment and management decisions for children with ID. OBJECTIVES: (1) compare disability and pain-related beliefs between RW and a sample with little experience in ID; (2) determine whether individuals' beliefs and personal characteristics are related to pain assessment and management decisions...
March 2017: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/28194004/genetic-contributions-to-self-reported-tiredness
#4
V Deary, S P Hagenaars, S E Harris, W D Hill, G Davies, D C M Liewald, A M McIntosh, C R Gale, I J Deary
Self-reported tiredness and low energy, often called fatigue, are associated with poorer physical and mental health. Twin studies have indicated that this has a heritability between 6 and 50%. In the UK Biobank sample (N=108 976), we carried out a genome-wide association study (GWAS) of responses to the question, 'Over the last two weeks, how often have you felt tired or had little energy?' Univariate GCTA-GREML found that the proportion of variance explained by all common single-nucleotide polymorphisms for this tiredness question was 8...
February 14, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28165774/factors-and-costs-associated-with-delay-in-treatment-initiation-and-prolonged-length-of-stay-with-inpatient-epoch-chemotherapy-in-patients-with-hematologic-malignancies
#5
Melissa K Accordino, Jason D Wright, Sowmya Vasan, Alfred I Neugut, Grace C Hillyer, Dawn L Hershman
Reducing delays related to inpatient chemotherapy may reduce healthcare costs. Using a national database, we identified patients with lymphoma/leukemia with ≥1 etoposide, vincristine, doxorubicin, cyclophosphamide, and prednisone (EPOCH) chemotherapy claim and evaluated chemotherapy initiation delay (ID), >1 day from admission. Standard tests/procedures prior to initiation were evaluated. Among 4453 inpatient cycles, 19.7% had ID, odds ratio 2.28 (95% confidence interval: 1.83-2.85) with cycle 1 compared to cycle 2, and mean costs were higher in patients with ID than without ID (p < ...
March 16, 2017: Cancer Investigation
https://www.readbyqxmd.com/read/28141509/development-validation-and-testing-costs-of-an-in-house-real-time-polymerase-chain-reaction-assay-for-the-detection-of-chlamydia-trachomatis
#6
Camila Gurgel Dos Santos, Meritxell Sabidó, André Luiz Leturiondo, Cynthia de Oliveira Ferreira, Thielle Pereira da Cruz, Adele Schwartz Benzaken
To improve screening of Chlamydia trachomatis (CT) in Brazil, an accurate and affordable method is needed. The objective of this study was to develop and assess the performance and costs of a new in-house real time polymerase chain reaction (qPCR) assay for the diagnosis of CT infection. Asymptomatic women aged 14-25 years who attended primary health services in Manaus, Brazil, were screened for CT using the Digene® Hybrid Capture II (HCII CT-ID) CT-ID DNA-test. A subset of cervical specimens were tested using an in-house qPCR and a commercial qPCR (Artus qPCR) as a reference test...
January 27, 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28067796/combined-effects-of-androgen-and-growth-hormone-on-osteoblast-marker-expression-in-mouse-c2c12-and-mc3t3-e1-cells-induced-by-bone-morphogenetic-protein
#7
Kosuke Kimura, Tomohiro Terasaka, Nahoko Iwata, Takayuki Katsuyama, Motoshi Komatsubara, Ryota Nagao, Kenichi Inagaki, Fumio Otsuka
Osteoblasts undergo differentiation in response to various factors, including growth factors and steroids. Bone mass is diminished in androgen- and/or growth hormone (GH)-deficient patients. However the functional relationship between androgen and GH, and their combined effects on bone metabolism, remains unclear. Here we investigated the mutual effects of androgen and GH on osteoblastic marker expression using mouse myoblastic C2C12 and osteoblast-like MC3T3-E1 cells. Combined treatment with dihydrotestosterone (DHT) and GH enhanced BMP-2-induced expression of Runx2, ALP, and osteocalcin mRNA, compared with the individual treatments in C2C12 cells...
January 5, 2017: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/28065236/expressions-of-inhibitors-of-dna-binding-1-and-matrix-metalloproteinase-9-in-colorectal-adenocarcinoma-tissues-and-their-correlations-with-microvessel-density
#8
Xue-Liang Wu, Jun Xue, Li-Kun Wang, Dong-Dong Yang, Ming Qu, Fei Guo, Guang-Yuan Sun, Lei Han, Rui-Min Yang
Objective To explore the expressions of inhibitors of DNA binding-1 (Id-1) and matrix metalloproteinase-9 (MMP-9) in colorectal carcinoma tissues and its correlation with microvessel density (MVD). Methods The expressions of Id-1 and MMP-9 as well as CD34-labelled MVD in colorectal adenocarcinoma tissues (n=50) and normal adjacent tissues (n=50) were examined by immunohistochemistry. Results The positive expressions of Id-1 and MMP-9 were seen in 72.00% (36/50) and 78.00%(39/50) of colorectal adenocarcinoma tissues,which were significantly higher than those [24...
December 20, 2016: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
https://www.readbyqxmd.com/read/27995128/intravenous-topiramate-pharmacokinetics-in-dogs-with-naturally-occurring-epilepsy
#9
Irene Vuu, Lisa D Coles, Patricia Maglalang, Ilo E Leppik, Greg Worrell, Daniel Crepeau, Usha Mishra, James C Cloyd, Edward E Patterson
RATIONALE: Barriers to developing treatments for human status epilepticus include the inadequacy of experimental animal models. In contrast, naturally occurring canine epilepsy is similar to the human condition and can serve as a platform to translate research from rodents to humans. The objectives of this study were to characterize the pharmacokinetics of an intravenous (IV) dose of topiramate (TPM) in dogs with epilepsy and evaluate its effect on intracranial electroencephalographic (iEEG) features...
2016: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/27908498/hydrophilic-interaction-and-reversed-phase-mixed-mode-liquid-chromatography-coupled-to-high-resolution-tandem-mass-spectrometry-for-polar-lipids-analysis
#10
Sara Granafei, Pietro Azzone, Vito Alessandro Spinelli, Ilario Losito, Francesco Palmisano, Tommaso R I Cataldi
A hydrophilic interaction liquid chromatography (HILIC) fused-core column (150×2.1mm ID, 2.7μm particle size) and a short reversed-phase liquid chromatography (RPLC) column (20mm×2.1mm ID, 1.9μm) were serially coupled to perform mixed-mode chromatography (MMC) on complex mixtures of phospholipids (PL). Mobile phase composition and gradient elution program were, preliminarily, optimized using a mixture of phosphatidylcholines (PC), phosphatidylethanolamines (PE), their corresponding lyso-forms (LPC and LPE), and sphingomyelins (SM)...
December 16, 2016: Journal of Chromatography. A
https://www.readbyqxmd.com/read/27864248/the-challenge-of-universal-eye-health-in-latin-america-distributive-inequality-of-ophthalmologists-in-14-countries
#11
Hannah Hong, Oscar J Mújica, José Anaya, Van C Lansingh, Ellery López, Juan Carlos Silva
BACKGROUND: No comprehensive study currently exists on the supply of ophthalmologists across Latin America. We explored sociogeographic inequalities in the availability and distribution of ophthalmologists across 14 Latin American countries. METHODS: The National Ophthalmologic Societies of Argentina, Bolivia, Brazil, Colombia, Costa Rica, Chile, the Dominican Republic, Ecuador, Guatemala, Mexico, Paraguay, Peru, Uruguay and Venezuela provided data on affiliated ophthalmologists by first-order subnational divisions in 2013...
November 18, 2016: BMJ Open
https://www.readbyqxmd.com/read/27832631/a-double-negative-feedback-interaction-between-microrna-29b-and-dnmt3a-3b-contributes-to-ovarian-cancer-progression
#12
Yue Teng, Xiaohang Zuo, Meng Hou, Yan Zhang, Chen Li, Wenjuan Luo, Xu Li
BACKGROUND: Epigenetic abnormalities are increasingly observed in multiple malignancies, including epithelial ovarian cancer (EOC), and their effects can be significantly counteracted by tumor-suppressor microRNAs, namely epi-miRNAs. Here, we investigated the role of miR-29b, a well-established epi-miRNA, in the DNA methylation regulation of EOC cells. METHODS: The correlation between miR-29b and DNMT3A/3B expression was evaluated by RT-qPCR, western blotting and immunohistochemical analysis...
2016: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/27752090/dnmt1-regulates-the-myogenic-lineage-specification-of-muscle-stem-cells
#13
Renjing Liu, Kun-Yong Kim, Yong-Wook Jung, In-Hyun Park
DNA methylation is an important epigenetic mark that regulates gene expression. Dnmt1 plays an important role in maintaining DNA methylation patterns on daughter DNA strands. Studies have shed light into the functional role of Dnmt1 regulation in the hematopoietic and epidermal systems. Here we show that Dnmt1 is required for myogenesis. Loss of Dnmt1 results in reduced expression of myogenic genes and defects in myogenic differentiation. We have utilized a conditional knockout mouse approach to examine the functional consequences of Dnmt1 depletion specifically in the developing muscle...
October 18, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27633352/knockdown-of-rpl9-expression-inhibits-colorectal-carcinoma-growth-via-the-inactivation-of-id-1-nf-%C3%AE%C2%BAb-signaling-axis
#14
In Hye Baik, Guk-Heui Jo, Daekwan Seo, Min Ji Ko, Chi Heum Cho, Min Goo Lee, Yun-Han Lee
Ribosomal protein L9 (RPL9), a component of the 60S subunit for protein synthesis, is upregulated in human colorectal cancer. In the present study, we investigated whether RPL9 gained extraribosomal function during tumorigenesis and whether targeting of RPL9 with small interfering (si) RNA could alter the course of colorectal cancer progression. Our results showed that siRNA knockdown of RPL9 suppresses colorectal cancer (CRC) cell growth and long-term colony formation through an increase in sub-G1 cell population and a strong induction of apoptotic cell death...
November 2016: International Journal of Oncology
https://www.readbyqxmd.com/read/27540101/exploring-academics-views-on-designs-methods-characteristics-and-outcomes-of-inclusive-health-research-with-people-with-intellectual-disabilities-a-modified-delphi-study
#15
T K Frankena, J Naaldenberg, M Cardol, J V Meijering, G Leusink, H M J van Schrojenstein Lantman-de Valk
BACKGROUND: The British Medical Journal's (BMJ's) patient revolution strives for collaboration with patients in healthcare and health research. This paper studies collaboration with people with intellectual disabilities (ID) in health research, also known as inclusive health research. Currently, transparency and agreement among academics is lacking regarding its main aspects, preventing upscaling of the patient revolution. OBJECTIVE: This study aims to gain agreement among academics on 3 aspects of inclusive health research for people with ID: (1) designs and methods, (2) most important characteristics and (3) outcomes...
2016: BMJ Open
https://www.readbyqxmd.com/read/27516242/iron-deficiency-anemia-and-mortality-in-renal-transplant-recipients
#16
Michele F Eisenga, Isidor Minović, Stefan P Berger, Jenny E Kootstra-Ros, Else van den Berg, Ineke J Riphagen, Gerjan Navis, Peter van der Meer, Stephan J L Bakker, Carlo A J M Gaillard
Anemia, iron deficiency anemia (IDA), and iron deficiency (ID) are highly prevalent in renal transplant recipients (RTR). Anemia is associated with poor outcome, but the role of ID is unknown. Therefore, we aimed to investigate the association of ID, irrespective of anemia, with all-cause mortality in RTR. Cox regression analyses were used to investigate prospective associations. In 700 RTR, prevalences of anemia, IDA, and ID were 34%, 13%, and 30%, respectively. During follow-up for 3.1 (2.7-3.9) years, 81 (12%) RTR died...
November 2016: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/27459117/fucoidan-induced-id-1-suppression-inhibits-the-in-vitro-and-in-vivo-invasion-of-hepatocellular-carcinoma-cells
#17
Yuri Cho, Eun Ju Cho, Jeong-Hoon Lee, Su Jong Yu, Yoon Jun Kim, Chung Yong Kim, Jung-Hwan Yoon
Hepatocellular carcinoma (HCC) is a fast growing tumor associated with a high tendency for vascular invasion and distant metastasis. Recently, we reported that fucoidan displays inhibitory effect on proliferation and invasion of HCC cells. In this study, we investigated the anti-metastatic effect of fucoidan on HCC cells and the key signal that modulates metastasis. The anti-metastatic effect of fucoidan was evaluated in vitro using an invasion assay with human HCC cells (Huh-7, SNU-761, and SNU-3085) under both normoxic (20% O2 and 5% CO2, at 37°C) and hypoxic (1% O2, 5% CO2, and 94% N2, at 37°C) conditions...
October 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27391392/characterization-of-the-pigment-fraction-in-sweet-bell-peppers-capsicum-annuum-l-harvested-at-green-and-overripe-yellow-and-red-stages-by-offline-multidimensional-convergence-chromatography-liquid-chromatography-mass-spectrometry
#18
Ivana Bonaccorsi, Francesco Cacciola, Margita Utczas, Veronica Inferrera, Daniele Giuffrida, Paola Donato, Paola Dugo, Luigi Mondello
Offline multidimensional supercritical fluid chromatography combined with reversed-phase liquid chromatography was employed for the carotenoid and chlorophyll characterization in different sweet bell peppers (Capsicum annuum L.) for the first time. The first dimension consisted of an Acquity HSS C18 SB (100 × 3 mm id, 1.8 μm particles) column operated with a supercritical mobile phase in an ultra-performance convergence chromatography system, whereas the second dimension was performed in reversed-phase mode with a C30 (250 × 4...
September 2016: Journal of Separation Science
https://www.readbyqxmd.com/read/27390286/pilot-mouse-study-of-1-mm-inner-diameter-id-vascular-graft-using-electrospun-poly-ester-urea-nanofibers
#19
Yaohua Gao, Tai Yi, Toshiharu Shinoka, Yong Ung Lee, Darrell H Reneker, Christopher K Breuer, Matthew L Becker
An off-the-shelf, small diameter tissue engineered vascular graft (TEVG) would be transformative to surgeons in multiple subspecialties. Herein, the results of a small diameter (ID ≈ 1 mm) vascular graft constructed from resorbable, amino acid-based poly(ester urea) (PEU) are reported. Electrospun PEU grafts of two different wall thicknesses (type A: 250 μm; type B: 350 μm) are implanted as abdominal infra-renal aortic grafts in a severe combined immune deficient/beige mouse model and evaluated for vessel remodeling over one year...
September 2016: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/27126345/factors-influencing-internal-medicine-resident-choice-of-infectious-diseases-or-other-specialties-a-national-cross-sectional-study
#20
Erin M Bonura, Eun Sul Lee, Katrina Ramsey, Wendy S Armstrong
BACKGROUND: Only 49% of infectious diseases (ID) fellowship programs were filled in 2015 through the national match, but little is known about internal medicine (IM) resident perceptions of ID and factors related to IM resident career choice. METHODS: We conducted 25 interviews and disseminated a Web-based survey to graduating IM residents in the United States utilizing a 2-stage sampling strategy. Participants were categorized into 3 groups based on interest in ID: (1) applied/intended to apply to ID; (2) interested in ID but did not apply; (3) never interested in ID...
July 15, 2016: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
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