Hui Shen, Ya Gao, Dedong Ge, Meng Tan, Qing Yin, Tong-You Wade Wei, Fangzhou He, Tzong-Yi Lee, Zhongyan Li, Yuqin Chen, Qifeng Yang, Zhangyu Liu, Xinxin Li, Zixuan Chen, Yi Yang, Zhengang Zhang, Patricia A Thistlethwaite, Jian Wang, Atul Malhotra, Jason X-J Yuan, John Y-J Shyy, Kaizheng Gong
BACKGROUND: An imbalance of antiproliferative BMP (bone morphogenetic protein) signaling and proliferative TGF-β (transforming growth factor-β) signaling is implicated in the development of pulmonary arterial hypertension (PAH). The posttranslational modification (eg, phosphorylation and ubiquitination) of TGF-β family receptors, including BMPR2 (bone morphogenetic protein type 2 receptor)/ALK2 (activin receptor-like kinase-2) and TGF-βR2/R1, and receptor-regulated (R) Smads significantly affects their activity and thus regulates the target cell fate...
April 1, 2024: Circulation