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Plasma microRNA

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https://www.readbyqxmd.com/read/28434388/microrna-221-3p-is-up-regulated-and-serves-as-a-potential-biomarker-in-pancreatic-cancer
#1
Feng Li, Jian-Wei Xu, Lei Wang, Han Liu, Ye Yan, San-Yuan Hu
It has been demonstrated that circulating MicroRNAs (miRNAs) could be potential biomarkers for cancer diagnosis and prognosis. For pancreatic cancer (PCa), little is known about miR-221-3p biological function or its prognostic value. In the current study, we profiled miR-221-3p expression in PCa cell lines. Compared with normal pancreases ductal epithelial cells, miR-221-3p is up-regulated in all PCa cell lines analysed. In SW1990 cells, overexpression of miR-221-3p increased cell proliferation and inhibited apoptosis, while inhibition of miR-221-3p decreased cell growth rate and promoted apoptosis...
April 21, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28431866/circulating-micrornas-signature-correlates-with-positive-18-f-fluorodeoxyglucose-positron-emission-tomography-in-patients-with-abdominal-aortic-aneurysm
#2
Audrey Courtois, Betty Nusgens, Nancy Garbacki, Roland Hustinx, Pierre Gomez, Jean-Olivier Defraigne, Alain C Colige, Natzi Sakalihasan
BACKGROUND: Prediction of abdominal aortic aneurysm (AAA) rupture is a challenging issue. Small noncoding microRNAs (miRNAs) are potent regulators of gene expression and are considered as valuable circulating biomarkers. Recently, [(18)F]fluorodeoxyglucose (FDG) uptake detected by positron emission tomography (PET) in AAA was correlated with cellular and molecular alterations involved in wall instability and its potential rupture. Our study aimed at identifying circulating miRNAs correlated with a positive PET that could help discriminate patients at high risk of rupture...
April 18, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28429674/targeting-the-role-of-lipoprotein-a-in-stroke
#3
Mahdi Garelnabi, Zahra Mazhar, Andrew Hughes
Stroke is the third leading cause of death in the United States, behind only heart disease and cancer, with over 140,000 associated deaths per year. Considerable research is ongoing to examine the role of modifiable risk factors which may cause or contribute to a stroke occurring. Although age and family history are generally considered to be major risk factors, there are several modifiable and non-modifiable risk factors that are linked to the pathogenesis of a stroke. Lipoprotein (a), or Lp(a), is a type of low-density lipoprotein containing an integral apoB100 component with an attached ApoA1 isoform via a disulfide linkage...
April 21, 2017: Cardiovascular & Hematological Disorders Drug Targets
https://www.readbyqxmd.com/read/28427524/kallistatin-suppresses-cancer-development-by-multi-factorial-actions
#4
REVIEW
Julie Chao, Pengfei Li, Lee Chao
Kallistatin was first identified in human plasma as a tissue kallikrein-binding protein and a serine proteinase inhibitor. Kallistatin via its two structural elements regulates differential signaling cascades, and thus a wide spectrum of biological functions. Kallistatin's active site is essential for: inhibiting tissue kallikrein's activity; stimulating endothelial nitric oxide synthase and sirtuin 1 expression and activation; and modulating the synthesis of the microRNAs, miR-34a, miR-21 and miR-203. Kallistatin's heparin-binding site is crucial for antagonizing the signaling pathways of vascular endothelial growth factor, tumor necrosis factor-α, Wnt, transforming growth factor-β and epidermal growth factor...
May 2017: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/28425921/plasma-micro-rna-alterations-appear-late-in-pancreatic-cancer
#5
Oskar Franklin, Pär Jonsson, Ola Billing, Erik Lundberg, Daniel Öhlund, Hanna Nyström, Christina Lundin, Henrik Antti, Malin Sund
OBJECTIVES: The aim of this research was to study whether plasma microRNAs (miRNA) can be used for early detection of pancreatic cancer (PC) by analyzing prediagnostic plasma samples collected before a PC diagnosis. BACKGROUND: PC has a poor prognosis due to late presenting symptoms and early metastasis. Circulating miRNAs are altered in PC at diagnosis but have not been evaluated in a prediagnostic setting. METHODS: We first performed an initial screen using a panel of 372 miRNAs in a retrospective case-control cohort that included early-stage PC patients and healthy controls...
January 3, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28424819/plasma-micrornas-characterising-patients-with-immune-thrombocytopenic-purpura
#6
Bin Zuo, Juping Zhai, Lifang You, Yunxiao Zhao, Jianfeng Yang, Zhen Weng, Lan Dai, Qingyu Wu, Changgeng Ruan, Yang He
Altered microRNA (miRNA) expression has been reported in patients with immune thrombocytopenic purpura (ITP). However, the detailed expression profiling of cell-free circulating miRNAs in ITP patients has not been fully investigated. In this study, we aimed to examine plasma miRNAs in ITP patients and evaluate their diagnostic values. Plasma samples from 74 ITP patients and 58 healthy controls were obtained and allocated into discovery, validation, and therapy-response sets. Initial screen with a miRNA microarray assay identified 23 miRNAs with different levels between ITP patients and healthy controls (>1...
April 20, 2017: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/28423578/endothelial-microparticles-delivering-microrna-155-into-t-lymphocytes-are-involved-in-the-initiation-of-acute-graft-versus-host-disease-following-allogeneic-hematopoietic-stem-cell-transplantation
#7
Ran Zhang, Xiaoxiao Wang, Mei Hong, Ting Luo, Miaomiao Zhao, Haorui Shen, Jun Fang, Xiaojie Li, Sibin Zang, Ping Chen, Dimin Nie, Peng Zheng, Qiuling Wu, Linghui Xia
Endothelial microparticles (EMPs) upregulation has been observed in acute graft-versus-host disease (aGVHD) after allogeneic hematopoietic stem cell transplantation (allo-HSCT). However, the role of EMPs remains unclear. We found that EMPs derived from TNF-α-stimulated human umbilical vein endothelial cells (EA.hy926) concentrated more microRNA-155 (miR-155) compared with maternal cells. The miR-155 levels in MPs from peripheral blood of aGVHD patients and mice were remarkably elevated and significantly higher than the levels in plasma...
April 4, 2017: Oncotarget
https://www.readbyqxmd.com/read/28422008/arabidopsis-14-3-3-epsilon-members-contribute-to-polarity-of-pin-auxin-carrier-and-auxin-transport-related-development
#8
Jutta Keicher, Nina Jaspert, Katrin Weckermann, Claudia Möller, Christian Throm, Aaron Kintzi, Claudia Oecking
Eukaryotic 14-3-3 proteins have been implicated in the regulation of diverse biological processes by phosphorylation-dependent protein-protein interactions. The Arabidopsis genome encodes two groups of 14-3-3s, one of which - epsilon - is thought to fulfill conserved cellular functions. Here, we assessed the in vivo role of the ancestral 14-3-3 epsilon group members. Their simultaneous and conditional repression by RNA interference and artificial microRNA in seedlings led to altered distribution patterns of the phytohormone auxin and associated auxin transport-related phenotypes, such as agravitropic growth...
April 19, 2017: ELife
https://www.readbyqxmd.com/read/28413462/identification-of-mirna-biomarkers-of-pneumonia-using-rna-sequencing-and-bioinformatics-analysis
#9
Sai Huang, Cong Feng, Yong-Zhi Zhai, Xuan Zhou, Bei Li, Li-Li Wang, Wei Chen, Fa-Qin Lv, Tan-Shi Li
Pneumonia is a lower respiratory tract infection that causes dramatic mortality worldwide. The present study aimed to investigate the pathogenesis of pneumonia and identify microRNA (miRNA) biomarkers as candidates for targeted therapy. RNA from the peripheral blood plasma of participants with pneumonia (severe, n=9; non-severe, n=9) and controls (n=9) was isolated and paired-end sequencing was performed on an Illumina HiSeq4000 system. Following the processing of raw reads, the sequences were aligned against the Genome Reference Consortium human genome assembly 38 reference genome using Bowtie2 software...
April 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28405738/evaluation-of-mir-506-and-mir-4316-expression-in-early-and-non-invasive-diagnosis-of-colorectal-cancer
#10
Paweł Krawczyk, Tomasz Powrózek, Tomasz Olesiński, Adam Dmitruk, Joanna Dziwota, Dariusz Kowalski, Janusz Milanowski
PURPOSE: Examination of the entire colon by colonoscopy remains the golden standard for screening of colorectal cancer (CRC). However, patients are reluctant to perform invasive colonoscopies because of interference with their intimacy. Therefore, the potential use of non-invasive analysis of microRNAs expression in liquid biopsy as a novel biomarker for early CRC has investigated in several studies. In this study, we analyzed the expression of two novel microRNAs: miR-506 and miR-4316, which have never been examined in CRC...
April 12, 2017: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/28399937/specific-circulating-microrna-signature-of-bicuspid-aortic-valve-disease
#11
Neus Martínez-Micaelo, Raúl Beltrán-Debón, Isabel Baiges, Marta Faiges, Josep M Alegret
BACKGROUND: We aimed to determine the circulating miRNA expression profile associated with BAV and aortic dilation to provide diagnostic and prognostic biomarkers for BAV and/or aortic dilation. METHODS AND RESULTS: We applied a miRNome-wide microarray approach using plasma samples (n = 24) from healthy tricuspid aortic valve individuals, BAV patients and BAV patients with aortic dilation to compare and identify the specific miRNAs associated with BAV and aortic dilation...
April 11, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/28399134/an-improved-method-to-quantitate-mature-plant-microrna-in-biological-matrices-using-modified-periodate-treatment-and-inclusion-of-internal-controls
#12
Haiqiu Huang, Jamin Roh, Cindy D Davis, Thomas T Y Wang
MicroRNAs (miRNAs) ubiquitously exist in microorganisms, plants, and animals, and appear to modulate a wide range of critical biological processes. However, no definitive conclusion has been reached regarding the uptake of exogenous dietary small RNAs into mammalian circulation and organs and cross-kingdom regulation. One of the critical issues is our ability to assess and distinguish the origin of miRNAs. Although periodate oxidation has been used to differentiate mammalian and plant miRNAs, validation of treatment efficiency and the inclusion of proper controls for this method were lacking in previous studies...
2017: PloS One
https://www.readbyqxmd.com/read/28395057/early-mir-223-upregulation-in-gastroesophageal-carcinogenesis
#13
Matteo Fassan, Deborah Saraggi, Laura Balsamo, Stefano Realdon, Marco Scarpa, Carlo Castoro, Irene Coati, Roberta Salmaso, Fabio Farinati, Vincenza Guzzardo, Diletta Arcidiacono, Giada Munari, Pierluigi Gasparini, Nicola Veronese, Claudio Luchini, Nicola Valeri, Massimo Rugge
Objectives: To test miR-223 upregulation during gastric (intestinal-type) and Barrett esophageal carcinogenesis. Methods: miR-223 expression was assessed by quantitative reverse transcription polymerase chain reaction in a series of 280 gastroesophageal biopsy samples representative of the whole spectrum of phenotypic changes involved in both carcinogenetic cascades. The results were further validated by in situ hybridization on multiple tissue specimens obtained from six surgically treated gastroesophageal adenocarcinomas...
March 1, 2017: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28388588/non-coding-rnas-new-biomarkers-and-therapeutic-targets-for-esophageal-cancer
#14
Xiaobin Hou, Jiaxin Wen, Zhipeng Ren, Guoliang Zhang
Esophageal cancer is one of the most common gastrointestinal malignant diseases and there is still no effective treatment. The incidence of esophageal cancer in the world is relatively high and on the increase year by year. Thus, the elaboration on the carcinogenesis of esophageal cancer and the identification of new biomarkers and therapeutic targets is quite beneficial to optimizing the current therapeutic regimen for treating such deadly disease. More and more evidence has shown that non-coding RNAs play an important role in the development and progression of multiple human cancers, including esophageal cancer...
March 30, 2017: Oncotarget
https://www.readbyqxmd.com/read/28386155/corrigendum-to-predictive-value-of-plasma-microrna-216a-b-in-the-diagnosis-of-esophageal-squamous-cell-carcinoma
#15
Shuling Dong, Huiqing Yin, Cuicui Dong, Kaiyan Sun, Pin Lv, Weiwei Meng, Liang Ming, Fucheng He
[This corrects the article DOI: 10.1155/2016/1857067.].
2017: Disease Markers
https://www.readbyqxmd.com/read/28384161/microrna-hsa-mir-134-is-a-circulating-biomarker-for-mesial-temporal-lobe-epilepsy
#16
Simoni H Avansini, Beatriz Pereira de Sousa Lima, Rodrigo Secolin, Marilza L Santos, Ana Carolina Coan, André S Vieira, Fábio R Torres, Benilton S Carvalho, Marina K M Alvim, Márcia E Morita, Clarissa L Yasuda, Luciana R Pimentel-Silva, Danyella B Dogini, Fabio Rogerio, Fernando Cendes, Iscia Lopes-Cendes
Epilepsy is misdiagnosed in up to 25% of patients, leading to serious and long-lasting consequences. Recently, circulating microRNAs have emerged as potential biomarkers in a number of clinical scenarios. The purpose of this study was to identify and to validate circulating microRNAs that could be used as biomarkers in the diagnosis of epilepsy. Quantitative real-time PCR was used to measure plasma levels of three candidate microRNAs in two phases of study: an initial discovery phase with 14 patients with mesial temporal lobe epilepsy (MTLE), 13 with focal cortical dysplasia (FCD) and 16 controls; and a validation cohort constituted of an independent cohort of 65 patients with MTLE and 83 controls...
2017: PloS One
https://www.readbyqxmd.com/read/28382463/micrornas-association-in-the-cardiac-hypertrophy-secondary-to-complex-congenital-heart-disease-in-children
#17
Ma C Sánchez-Gómez, K A García-Mejía, M Pérez-Díaz Conti, G Díaz-Rosas, I Palma-Lara, R Sánchez-Urbina, M Klünder-Klünder, J A Botello-Flores, N A Balderrábano-Saucedo, A Contreras-Ramos
Complex congenital heart disease (CHD) affects cardiac blood flow, generating a pressure overload in the compromised ventricles and provoking hypertrophy that over time will induce myocardial dysfunction and cause a potential risk of imminent death. Therefore, the early diagnosis of complex CHD is paramount during the first year of life, with surgical treatment of patients favoring survival. In the present study, we analyzed cardiac tissue and plasma of children with cardiac hypertrophy (CH) secondary to CHD for the expression of 11 miRNAs specific to CH in adults...
April 5, 2017: Pediatric Cardiology
https://www.readbyqxmd.com/read/28382439/plasma-level-of-mir-93-is-associated-with-higher-risk-to-develop-type-2-diabetic-retinopathy
#18
Hui-Ling Zou, Yan Wang, Qiang Gang, Ying Zhang, Yu Sun
PURPOSE: MicroRNA-93 (miR-93) usually acts as a promoter of tumor progression in several human carcinomas. It has been found distinctly high in eyes with proliferative diabetic retinopathy (DR). The present study aims to investigate the role of plasma miR-93 in the progression of type 2 diabetic retinopathy (T2DR). METHODS: Our study subjects were made up of 140 type 2 diabetes mellitus (T2DM) patients who were assigned into DR (DR patients, n = 75), NDR (non-DR patients, n = 65), and control (healthy individuals, n = 127) groups...
April 5, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28381180/follow-up-of-gestational-trophoblastic-disease-neoplasia-via-quantification-of-circulating-nucleic-acids-of-placental-origin-using-c19mc-micrornas-hypermethylated-rassf1a-and-sry-sequences
#19
Ilona Hromadnikova, Katerina Kotlabova, Ladislav Krofta, Filip Hron
The aim of the study was to evaluate the effectiveness of placental-specific markers, extracellular fetal DNA (sex-determining region Y and hypermethylated RASSF1A sequences) and circulating C19MC microRNAs (miR-516-5p, miR-517-5p, miR-518b, miR-520a-5p, miR-520h, miR-525, and miR-526a) for the diagnosis and consecutive follow-up of gestational trophoblastic disease/neoplasia. Increased levels of extracellular fetal DNA and C19MC microRNAs were detected in patients with active disease when compared with the period when the patients reached remission of the disease...
April 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28380431/a-six-microrna-signature-in-plasma-was-identified-as-a-potential-biomarker-in-diagnosis-of-esophageal-squamous-cell-carcinoma
#20
Xin Zhou, Wei Wen, Jun Zhu, Zebo Huang, Lan Zhang, Huo Zhang, Lian-Wen Qi, Xia Shan, Tongshan Wang, Wenfang Cheng, Danxia Zhu, Yin Yin, Yan Chen, Wei Zhu, Yongqian Shu, Ping Liu
The differential expression of microRNAs (miRNAs) in plasma of esophageal squamous cell carcinoma (ESCC) patients may serve as a diagnostic biomarker. A four-stage study was conducted to identify plasma miRNAs with potential in detecting ESCC. Exiqon panels (2 ESCC pools vs. 1 normal control (NC) pool) were applied in the screening phase to obtain miRNA profiles. The identified miRNAs were further evaluated through training (36 ESCC VS. 42 NCs) and testing stages (101 ESCC VS. 113 NCs) with qRT-PCR assays. A six-miRNA signature including up-regulated miR-106a, miR-18a, miR-20b, miR-486-5p, miR-584 and down-regulated miR-223-3p in ESCC was identified...
March 23, 2017: Oncotarget
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