M Manook, J Kwun, C Burghuber, K Samy, M Mulvihill, J Yoon, H Xu, A L MacDonald, K Freischlag, V Curfman, E Branum, D Howell, A B Farris, R A Smith, S Sacks, A Dorling, N Mamode, S J Knechtle
Early activation of coagulation is an important factor in the initiation of innate immunity, as characterized by thrombotic microangiopathy (TMA). In transplantation, systemic anticoagulation is difficult due to bleeding. A novel "cytotopic" agent, thrombalexin (TLN), combines a cell-membrane-bound (myristoyl tail) anti-thrombin (hirudin-like peptide [HLL]), which can be perfused directly to the donor organ or cells. Thromboelastography was used to measure time to clot formation (r-time) in both rhesus and human blood, comparing TLN versus HLL (without cytotopic tail) versus negative control...
August 2017: American Journal of Transplantation