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https://www.readbyqxmd.com/read/28231048/original-research-paper-formulation-and-pharmaceutical-development-of-quetiapine-fumarate-sustained-release-matrix-tablets-using-a-qbd-approach
#1
Alexandru Gavan, Alina Porfire, Cristina Marina, Ioan Tomuta
The main objective of the present study was to apply QbD methodology in the development of once-a-day sustained release quetiapine tablets. The quality target product profile (QTPP) was defined after the pharmaceutical properties and kinetic release of the innovator product, Seroquel XR 200 mg. For the D-optimal experimental design, the level and ratio of matrix forming agents and the type of extragranular diluent were chosen as independent inputs, which represented critical formulation factors. The critical quality attributes (CQAs) studied were the cumulative percentages of quetiapine released after certain time intervals...
March 1, 2017: Acta Pharmaceutica
https://www.readbyqxmd.com/read/28230752/impact-of-particular-matter-exposure-and-surrounding-greenness-on-chronic-absenteeism-in-massachusetts-public-schools
#2
Piers MacNaughton, Erika Eitland, Itai Kloog, Joel Schwartz, Joseph Allen
Chronic absenteeism is associated with poorer academic performance and higher attrition in kindergarten to 12th grade (K-12) schools. In prior research, students who were chronically absent generally had fewer employment opportunities and worse health after graduation. We examined the impact that environmental factors surrounding schools have on chronic absenteeism. We estimated the greenness (Normalized Difference Vegetation Index (NDVI)) and fine particulate matter air pollution (PM2.5) within 250 m and 1000 m respectively of each public school in Massachusetts during the 2012-2013 academic year using satellite-based data...
February 20, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28230108/mediation-pathways-and-effects-of-green-structures-on-respiratory-mortality-via-reducing-air-pollution
#3
Yu-Sheng Shen, Shih-Chun Candice Lung
Previous studies have shown both health and environmental benefits of green spaces, especially in moderating temperature and reducing air pollution. However, the characteristics of green structures have been overlooked in previous investigations. In addition, the mediation effects of green structures on respiratory mortality have not been assessed. This study explores the potential mediation pathways and effects of green structure characteristics on respiratory mortality through temperature, primary and secondary air pollutants separately using partial least squares model with data from Taiwan...
February 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28229396/statistical-approaches-to-longitudinal-data-analysis-in-neurodegenerative-diseases-huntington-s-disease-as-a-model
#4
REVIEW
Tanya P Garcia, Karen Marder
Understanding the overall progression of neurodegenerative diseases is critical to the timing of therapeutic interventions and design of effective clinical trials. Disease progression can be assessed with longitudinal study designs in which outcomes are measured repeatedly over time and are assessed with respect to risk factors, either measured repeatedly or at baseline. Longitudinal data allows researchers to assess temporal disease aspects, but the analysis is complicated by complex correlation structures, irregularly spaced visits, missing data, and mixtures of time-varying and static covariate effects...
February 2017: Current Neurology and Neuroscience Reports
https://www.readbyqxmd.com/read/28227744/classification-of-non-weight-bearing-lower-limb-movements-towards-a-potential-treatment-for-phantom-limb-pain-based-on-myoelectric-pattern-recognition
#5
Eva Lendaro, Max Ortiz-Catalan, Eva Lendaro, Max Ortiz-Catalan, Max Ortiz-Catalan, Eva Lendaro
Research in myoelectric pattern recognition (MPR) for the prediction of motor volition has primarily focused on the upper limbs. Recent studies in the lower limbs have mainly concentrated on prosthetic control, while MPR for lower limb rehabilitation purposes has received little attention. In this work we investigated the viability of a MPR system for the prediction of four degrees of freedom controlled in a near natural or physiologically appropriate fashion. We explored three different electrode configurations for acquiring electromyographic (EMG) signals: two targeted (bipolar and monopolar) and one untargeted (electrodes equally spaced axially)...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227715/bivariate-autoregressive-state-space-modeling-of-psychophysiological-time-series-data
#6
Daniel M Smith, Mohammadreza Abtahi, Amir Mohammad Amiri, Kunal Mankodiya, Daniel M Smith, Mohammadreza Abtahi, Amir Mohammad Amiri, Kunal Mankodiya, Kunal Mankodiya, Daniel M Smith, Mohammadreza Abtahi, Amir Mohammad Amiri
Heart rate (HR) and electrodermal activity (EDA) are often used as physiological measures of psychological arousal in various neuropsychology experiments. In this exploratory study, we analyze HR and EDA data collected from four participants, each with a history of suicidal tendencies, during a cognitive task known as the Paced Auditory Serial Addition Test (PASAT). A central aim of this investigation is to guide future research by assessing heterogeneity in the population of individuals with suicidal tendencies...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227534/quantifying-the-human-finger-reachable-space
#7
Trieu H Pham, Pubudu N Pathirana, Trieu H Pham, Pubudu N Pathirana, Trieu H Pham, Pubudu N Pathirana
Describing the flexibility of the hand using the reachable space concept has drawn the attention of many researchers in recent years. Existing approaches involving numerical techniques to obtain the reachable space are generally computationally expensive. In this study, we propose a resource-friendly approach to determine and quantify the bidimensional reachable space of the finger. The fundamental idea of the approach connects to a set of arc formulae for the boundary of the reachable space. These formulae of the boundary result a unique description to calculate the area of the reachable space using Green's theorem...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227411/source-imaging-of-simple-finger-movements-captured-during-auditory-response-tasks-using-space-time-frequency-based-sparsity-constraints
#8
Aritra Chaudhuri, Aurobinda Routray, Aritra Chaudhuri, Aurobinda Routray, Aurobinda Routray, Aritra Chaudhuri
Neural Information Flow during simple cognitive or motor actions is a significant research topic; one of which is a simple finger movement. In this paper, Electro-encephalograph (EEG) Source Imaging has been used to model the Neural Information flow, during performance of a simple Auditory Response Task (ART), specifically by employment of a space-time-frequency sparsity constrained based algorithm, namely, Spatio-temporal Unifying Tomography (STOUT). The estimated sources are then studied according to location defined based on Destrieux atlas...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226703/cerebra-a-3-d-visualization-tool-for-brain-network-extracted-from-fmri-data
#9
Baris Nasir, Fatos T Yarman Vural, Baris Nasir, Fatos T Yarman Vural, Baris Nasir, Fatos T Yarman Vural
In this paper, we introduce a new tool, CEREBRA, to visualize the 3D network of human brain, extracted from the fMRI data. The tool aims to analyze the brain connectivity by representing the selected voxels as the nodes of the network. The edge weights among the voxels are estimated by considering the relationships among the voxel time series. The tool enables the researchers to observe the active brain regions and the interactions among them by using graph theoretic measures, such as, the edge weight and node degree distributions...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28223465/assessment-of-bohr-and-enghoff-dead-space-equations-in-mechanically-ventilated-children
#10
Pierre Bourgoin, Florent Baudin, David Brossier, Guillaume Emeriaud, Marc Wysocki, Philippe Jouvet
BACKGROUND: Recent findings suggest that using alveolar PCO2 (PACO2 ) estimated by volumetric capnography in the Bohr equation instead of PaCO2 (Enghoff modification) could be appropriate for the calculation of physiological dead space to tidal volume ratio (VD/VT Bohr and VD/VT Enghoff, respectively). We aimed to describe the relationship between these 2 measurements in mechanically ventilated children and their significance in cases of ARDS. METHODS: From June 2013 to December 2013, mechanically ventilated children with various respiratory conditions were included in this study...
February 21, 2017: Respiratory Care
https://www.readbyqxmd.com/read/28222849/considering-employee-needs-during-a-catastrophe-requires-innovative-recovery-plans-why-traditional-workplace-recovery-solutions-are-outdated
#11
Joe Sullivan
Mobile technology has changed the way we live and operate, with co-working, flexible spaces and home office solutions that offer us the freedom to work when and where we choose. However, when disaster strikes the workplace, people are often the last to be considered in the recovery process. This paper examines strategies for businesses and their employees to continue working after a disaster strikes. It explores the trends in the market, the benefits and drawbacks of different approaches and the attitudes of continuity experts and small business owners who have the responsibility to ensure that businesses, and people, continue to function, even when their main place of work is inaccessible...
January 1, 2017: Journal of Business Continuity & Emergency Planning
https://www.readbyqxmd.com/read/28220098/intelligence-and-creativity-in-problem-solving-the-importance-of-test-features-in-cognition-research
#12
Saskia Jaarsveld, Thomas Lachmann
This paper discusses the importance of three features of psychometric tests for cognition research: construct definition, problem space, and knowledge domain. Definition of constructs, e.g., intelligence or creativity, forms the theoretical basis for test construction. Problem space, being well or ill-defined, is determined by the cognitive abilities considered to belong to the constructs, e.g., convergent thinking to intelligence, divergent thinking to creativity. Knowledge domain and the possibilities it offers cognition are reflected in test results...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28219262/individual-differences-in-the-flexibility-of-peripersonal-space
#13
Samuel B Hunley, Arwen M Marker, Stella F Lourenco
The current study investigated individual differences in the flexibility of peripersonal space (i.e., representational space near the body), specifically in relation to trait claustrophobic fear (i.e., fear of suffocating or being physically restricted). Participants completed a line bisection task with either a laser pointer (Laser condition), allowing for a baseline measure of the size of one's peripersonal space, or a stick (Stick condition), which produces expansion of one's peripersonal space. Our results revealed that individuals high in claustrophobic fear had larger peripersonal spaces than those lower in claustrophobic fear, replicating previous research...
January 2017: Experimental Psychology
https://www.readbyqxmd.com/read/28218637/mechanisms-of-chromosome-congression-during-mitosis
#14
REVIEW
Helder Maiato, Ana Margarida Gomes, Filipe Sousa, Marin Barisic
Chromosome congression during prometaphase culminates with the establishment of a metaphase plate, a hallmark of mitosis in metazoans. Classical views resulting from more than 100 years of research on this topic have attempted to explain chromosome congression based on the balance between opposing pulling and/or pushing forces that reach an equilibrium near the spindle equator. However, in mammalian cells, chromosome bi-orientation and force balance at kinetochores are not required for chromosome congression, whereas the mechanisms of chromosome congression are not necessarily involved in the maintenance of chromosome alignment after congression...
February 17, 2017: Biology
https://www.readbyqxmd.com/read/28217739/grounded-and-embodied-mathematical-cognition-promoting-mathematical-insight-and-proof-using-action-and-language
#15
Mitchell J Nathan, Candace Walkington
We develop a theory of grounded and embodied mathematical cognition (GEMC) that draws on action-cognition transduction for advancing understanding of how the body can support mathematical reasoning. GEMC proposes that participants' actions serve as inputs capable of driving the cognition-action system toward associated cognitive states. This occurs through a process of transduction that promotes valuable mathematical insights by eliciting dynamic depictive gestures that enact spatio-temporal properties of mathematical entities...
2017: Cogn Res Princ Implic
https://www.readbyqxmd.com/read/28215448/evolution-in-a-community-context-on-integrating-ecological-interactions-and-macroevolution
#16
REVIEW
Marjorie G Weber, Catherine E Wagner, Rebecca J Best, Luke J Harmon, Blake Matthews
Despite a conceptual understanding that evolution and species interactions are inextricably linked, it remains challenging to study ecological and evolutionary dynamics together over long temporal scales. In this review, we argue that, despite inherent challenges associated with reconstructing historical processes, the interplay of ecology and evolution is central to our understanding of macroevolution and community coexistence, and cannot be safely ignored in community and comparative phylogenetic studies...
February 16, 2017: Trends in Ecology & Evolution
https://www.readbyqxmd.com/read/28215283/why-neighborhoods-and-how-we-study-them-matter-for-adolescent-development
#17
T D Warner, R A Settersten
Adolescence is a sensitive developmental period marked by significant changes that unfold across multiple contexts. As a central context of development, neighborhoods capture-in both physical and social space-the stratification of life chances and differential distribution of resources and risks. For some youth, neighborhoods are springboards to opportunities; for others, they are snares that constrain progress and limit the ability to avoid risks. Despite abundant research on "neighborhood effects," scant attention has been paid to how neighborhoods are a product of social stratification forces that operate simultaneously to affect human development...
2017: Advances in Child Development and Behavior
https://www.readbyqxmd.com/read/28213824/an-approach-to-the-research-on-ion-and-water-properties-in-the-interphase-between-the-plasma-membrane-and-bulk-extracellular-solution
#18
REVIEW
Hiroshi Hibino, Madoka Takai, Hidenori Noguchi, Seishiro Sawamura, Yasufumi Takahashi, Hideki Sakai, Hitoshi Shiku
In vivo, cells are immersed in an extracellular solution that contains a variety of bioactive substances including ions and water. Classical electrophysiological analyses of epithelial cells in the stomach and small intestine have revealed that within a distance of several hundred micrometers above their apical plasma membrane, lies an extracellular layer that shows ion concentration gradients undetectable in the bulk phase. This "unstirred layer", which contains stagnant solutes, may also exist between the bulk extracellular solution and membranes of other cells in an organism and may show different properties...
February 17, 2017: Journal of Physiological Sciences: JPS
https://www.readbyqxmd.com/read/28213686/the-iswi-remodeler-in-plants-protein-complexes-biochemical-functions-and-developmental-roles
#19
REVIEW
Dongjie Li, Jie Liu, Wu Liu, Guang Li, Zhongnan Yang, Peng Qin, Lin Xu
Imitation Switch (ISWI) is a member of the ATP-dependent chromatin remodeling factor family, whose members move or restructure nucleosomes using energy derived from ATP hydrolysis. ISWI proteins are conserved in eukaryotes and usually form complexes with DDT (DNA-binding homeobox and different transcription factors)-domain proteins. Here, we review recent research on ISWI in the model plant Arabidopsis thaliana (AtISWI). AtISWI forms complexes with AtDDT-domain proteins, many of which have domain structures that differ from those of DDT-domain proteins in yeast and animals...
February 17, 2017: Chromosoma
https://www.readbyqxmd.com/read/28212675/sex-differences-in-the-association-of-skin-advanced-glycation-endproducts-with-knee-osteoarthritis-progression
#20
Charles B Eaton, Maria Sayeed, Syeda Ameernaz, Mary B Roberts, John D Maynard, Jeffrey B Driban, Timothy E McAlindon
BACKGROUND: The accumulation of advanced glycation endproducts in articular cartilage has been suggested as an etiologic factor in the development and progression of knee osteoarthritis (KOA). METHODS: We conducted a prospective cohort study of skin advanced glycation endproducts (sAGEs) measured non-invasively by skin intrinsic fluorescence and the relationship between sAGE KOA progression in 160 men and 287 women in a sub-cohort of the Osteoarthritis Initiative at a single site...
February 17, 2017: Arthritis Research & Therapy
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