keyword
https://read.qxmd.com/read/38115255/hypersensitivity-reaction-to-nedaplatin-a-case-report-and-literature-review
#21
REVIEW
Kelun Gan, Daiyuan Ma
RATIONALE: Although rare, systemic hypersensitivity reactions to nedaplatin chemotherapy arise rapidly and can be life-threatening. The causes are unclear, and multiple potential mechanisms exist. Here, we report a case of systemic hypersensitivity reaction to nedaplatin and review the literature to establish a recommended protocol. PATIENT CONCERNS: A 62-year-old man was being treated for squamous lung cancer with multiple metastases. On the first day of chemotherapy, 5 minutes after nedaplatin infusion, he developed panic, shortness of breath, and dyspnea with rapid heart rate, reduced oxygen saturation, and elevated blood pressure...
December 15, 2023: Medicine (Baltimore)
https://read.qxmd.com/read/38051468/follow-up-assessment-of-sleep-related-symptoms-in-patients-after%C3%A2-treatment-for%C3%A2-cancer-responses-to-continuous-positive-airway-pressure-treatment-for-co-morbid-obstructive-sleep-apnoea
#22
JOURNAL ARTICLE
Harini Subramanian, Ritu Trivedi, Veronika Fuchsova, Elisabeth Elder, Alison Brand, Julie Howle, Graham J Mann, Anna DeFazio, Terence Amis, Kristina Kairaitis
PURPOSE: To assess changes in sleep-related symptoms in patients with breast cancer, endometrial cancer and melanoma previously examined for sleep-related symptoms and the presence of PSG (polysomnography)-determined OSA, ≥ 3 years post-treatment; and to evaluate how CPAP treatment affects sleep-related symptoms in patients previously diagnosed with OSA. METHODS: Patients initially recruited from breast cancer, endometrial cancer, and melanoma follow-up clinics at Westmead Hospital (Sydney, Australia) participated in this questionnaire-based study...
December 5, 2023: Sleep & Breathing
https://read.qxmd.com/read/38049001/assessing-community-health-risks-from-exposure-to-ultrafine-particles-containing-transition-metals-in-the-greater-houston-area
#23
JOURNAL ARTICLE
Wei-Chung Su, Jinho Lee, Masoud Afshar, Kai Zhang, Inkyu Han
Ultrafine particles (UFPs) in urban air environments have been an essential public health concern. The inhalation of UFPs can introduce transition metals contained in the UFP into the human airways, leading to adverse health effects. Therefore, it is crucial to investigate urban air UFP exposure and health risks induced by transition metals. This research carried out a series of field measurements to study urban air UFP exposure in the Greater Houston Area. Three sampling sites in the Greater Houston Area representing varying levels of UFP exposures were selected...
December 2, 2023: Science of the Total Environment
https://read.qxmd.com/read/38048642/prediction-and-analysis-of-quality-markers-for-chuantieling-gel-patches-based-on-hplc-fingerprinting-and-network-pharmacology
#24
JOURNAL ARTICLE
Lixin Du, Huiling Lu, Yifei Xiao, Zhihua Guo, Ya Li
The Chuantieling gel patch (CGP), a traditional Chinese medicine compound, is an external treatment for asthma. It has shown remarkable effectiveness in alleviating asthma-related airway hyperresponsiveness and inflammation. Nevertheless, there is currently no information available regarding the analysis of quality markers for CGP, and there is a need for further improvement in quality control research. In this study, we developed an HPLC fingerprinting method for CGP and conducted a comprehensive methodological investigation...
December 4, 2023: Biomedical Chromatography: BMC
https://read.qxmd.com/read/38005657/the-state-of-the-art-on-graphene-based-sensors-for-human-health-monitoring-through-breath-biomarkers
#25
REVIEW
Pedro Catalão Moura, Paulo António Ribeiro, Maria Raposo, Valentina Vassilenko
The field of organic-borne biomarkers has been gaining relevance due to its suitability for diagnosing pathologies and health conditions in a rapid, accurate, non-invasive, painless and low-cost way. Due to the lack of analytical techniques with features capable of analysing such a complex matrix as the human breath, the academic community has focused on developing electronic noses based on arrays of gas sensors. These sensors are assembled considering the excitability, sensitivity and sensing capacities of a specific nanocomposite, graphene...
November 19, 2023: Sensors
https://read.qxmd.com/read/37997884/hyperinflation-and-reduced-diffusing-capacity-predict-prognosis-in-sclc-value-of-extended-pre-therapeutic-lung-function-testing
#26
JOURNAL ARTICLE
Kathrin Kahnert, Lilli Maria Lempert, Jürgen Behr, Laura Elsner, Toki Bolt, Amanda Tufman, Diego Kauffmann-Guerrero
BACKGROUND: Small cell lung cancer (SCLC) is characterized by aggressive growth and poor prognosis. Although SCLC affects nearly exclusively heavy smokers and leads to frequent respiratory symptoms, the impact of pre-therapeutic lung function testing in SCLC is sparely investigated until now. Therefore, we sought to examine whether we could find prognostic markers in pre-therapeutic lung function testing of SCLC patients. PATIENTS AND METHODS: We retrospectively analysed a cohort of 205 patients with the diagnosis of SCLC between 2010 and 2018...
2023: Therapeutic Advances in Respiratory Disease
https://read.qxmd.com/read/37943736/tracheostomy-care-quality-improvement-in-low-and-middle-income-countries-a-scoping-review
#27
JOURNAL ARTICLE
Msiba Selekwa, Ivy Maina, Tiffany Yeh, Aslam Nkya, Isaie Ncogoza, Roger C Nuss, Beatrice P Mushi, Sumaiya Haddadi, Katherine Van Loon, Elia Mbaga, Willybroad Massawe, David W Roberson, Nazima Dharsee, Baraka Musimu, Mary Jue Xu
Tracheostomy is a lifesaving, essential procedure performed for airway obstruction in the case of head and neck cancers, prolonged ventilator use, and for long-term pulmonary care. While successful quality improvement interventions in high-income countries such as through the Global Tracheostomy Collaborative significantly reduced length of hospital stay and decreased levels of anxiety among patients, limited literature exists regarding tracheostomy care and practices in low and middle-income countries (LMIC), where most of the world resides...
2023: PLOS Glob Public Health
https://read.qxmd.com/read/37910195/seasonal-disparities-of-human-health-risk-and-particle-bound-metal-characteristics-associated-with-atmospheric-particles-in-a-fishery-harbor
#28
JOURNAL ARTICLE
Cheng-Yun Tsai, Yen-Ping Peng, Chia-Hua Lin, Ku-Fan Chen, Chia-Hsiang Lai, Pin-Hao Qiu
The effects of atmospheric pollution from ship emissions have been considered for several harbors worldwide. The health risk assessment and source apportionment of particle-bound metals in a fishery harbor were investigated in this study. The most abundant metal elements in particulate matter (PM) on all sampling days in three seasons were Fe (280.94 ± 136.93 ng/m3 ), Al (116.40 ± 71.25 ng/m3 ), and Zn (110.55 ± 26.70 ng/m3 ). The ratios of V/Ni were 1...
November 1, 2023: Archives of Environmental Contamination and Toxicology
https://read.qxmd.com/read/37901763/sputum-induction-and-its-diagnostic-applications-in-inflammatory-airway-disorders-a-review
#29
REVIEW
Beatriz Goncalves, Ukpai A Eze
Sputum induction is a technique that covers the induction and the subsequent processing of the expectorate primarily for the analysis of cells and different inflammatory biomarkers present in the airways to further understand the pathophysiology of different inflammatory respiratory disorders such as asthma and chronic obstructive pulmonary disease (COPD) as well as the diagnosis of lung diseases such as lung cancer, tuberculosis, and Pneumocystis jirovecii pneumonia. It is a non-invasive, safe, cost-effective, and reliable technique reported to exhibit a high success rate...
2023: Front Allergy
https://read.qxmd.com/read/37899877/late-laryngeal-dysfunction-in-head-and-neck-cancer-survivors
#30
JOURNAL ARTICLE
Sarah Almas, Caroline C Jeffery
OBJECTIVES: Head and neck cancer (HNC) survivorship issues are areas of increasing research interest. Laryngeal dysfunction in HNC patients is particularly important given the importance of the larynx in voice, swallowing, and airway protection. The objective of our study is to characterize late laryngeal dysfunction in a cohort of long-term HNC survivors. METHODS: HNC survivors who were at least 2 years post-treatment were recruited prospectively for standard collection of videolaryngoscopy findings, videofluoroscopic swallowing studies, and assessment of clinical outcomes...
October 2023: Laryngoscope Investigative Otolaryngology
https://read.qxmd.com/read/37886437/differential-pulmonary-toxicity-and-autoantibody-formation-in-genetically-distinct-mouse-strains-following-combined-exposure-to-silica-and-diesel-exhaust-particles
#31
Lisa Mf Janssen, Frauke Lemaire, Nora Fopke Marain, Steven Ronsmans, Natasja Heylen, Arno Vanstapel, Greetje Vande Velde, Jeroen Aj Vanoirbeek, K Michael Pollard, Manosij Ghosh, Peter Hm Hoet
Background Inhalation of airborne particulate matter, such as silica and diesel exhaust particles, poses serious long-term respiratory health risks. Silica exposure can lead to silicosis and systemic autoimmune diseases, while DEP exposure is linked to asthma and cancer. Combined exposure to silica and DEP, common in mining, may have more severe effects. This study investigates the separate and combined effects of silica and DEP on lung injury, inflammation, and autoantibody formation in two genetically distinct mouse strains, thereby aiming at understanding the interplay between genetic susceptibility, particulate exposure, and disease outcomes...
October 9, 2023: Research Square
https://read.qxmd.com/read/37880425/preoperative-tracheostomy-is-associated-with-thyroid-gland-invasion-and-poorer-prognosis-in-laryngectomized-patients
#32
JOURNAL ARTICLE
Roee Noy, Nadeem Habashi, Sharon Akrish, Jacob Cohen, Yotam Shkedy
PURPOSE: Patients with laryngeal cancer may necessitate tracheostomy placement to alleviate compromised airways. However, the impact of tracheostomy on thyroid gland invasion and its implications for prognosis in individuals who further undergo total laryngectomy remains unclear. This study aimed to assess thyroid gland invasion rates and explore the 5-years disease-free and overall survival in laryngectomized patients stratified by preoperative tracheostomy. METHODS: All patients who underwent total laryngectomy for laryngeal cancer between 2003 and 2023 at a tertiary referral center were retrospectively reviewed...
October 25, 2023: European Archives of Oto-rhino-laryngology
https://read.qxmd.com/read/37820837/acr-lung-rads-v2022-assessment-categories-and-management-recommendations
#33
JOURNAL ARTICLE
Jared Christensen, Ashley Elizabeth Prosper, Carol C Wu, Jonathan Chung, Elizabeth Lee, Brett Elicker, Andetta R Hunsaker, Milena Petranovic, Kim L Sandler, Brendon Stiles, Peter Mazzone, David Yankelevitz, Denise Aberle, Caroline Chiles, Ella Kazerooni
The American College of Radiology (ACR) created the Lung CT Screening Reporting and Data System (Lung-RADS) in 2014 to standardize the reporting and management of screen-detected pulmonary nodules. Lung-RADS was updated to version 1.1 in 2019, and revised size thresholds for non-solid nodules, added classification criteria for peri-fissural nodules, and allowed for short-interval follow-up of rapidly enlarging nodules that may be infectious in etiology. Lung-RADS v2022, released in November 2022, provides several updates including guidance on the classification and management of atypical pulmonary cysts, juxtapleural nodules, airway-centered nodules, and potentially infectious findings...
October 9, 2023: Journal of the American College of Radiology: JACR
https://read.qxmd.com/read/37818502/correlation-of-fire-made-frailty-index-in-rural-elderly-mental-status-activities-of-daily-living-depression-and-events-with-sarcopenia-in-elderly-population-of-central-rural-india
#34
JOURNAL ARTICLE
Khalid I Khan, Shilpa A Gaidhane, Sunil Kumar, Sourya Acharya
Introduction Ageing results in the deprivation of various physiological reserves and resources resulting in the development of frailty. Frailty in turn brings various morbidities and dependence on others for the survival of an individual making him weak and vulnerable to various infective and non-infective insults leading to death. The present study assessed frailty in rural older adults of central India by using the Frailty Index in Rural Elderly - Mental Status, Activities of Daily Living, Depression, and Events (FIRE-MADE) and correlated it with sarcopenia assessed by the Asian Working Group for Sarcopenia (AWGS) and European Working Group on Sarcopenia in Older People (EWGSOP2) criteria...
September 2023: Curēus
https://read.qxmd.com/read/37804437/pd-1-inhibitors-combined-with-paclitaxel-albumin-bound-and-cisplatin-for-larynx-preservation-in-locally-advanced-laryngeal-and-hypopharyngeal-squamous-cell-carcinoma-a-retrospective-study
#35
JOURNAL ARTICLE
Qi Fang, Pengfei Xu, Fei Cao, Di Wu, Xuekui Liu
BACKGROUND: laryngeal and hypopharyngeal squamous cell carcinoma (SCC) is a common head and neck cancer with significant impact on quality of life due to its crucial roles in vocalization, airway protection, and swallowing. This retrospective study aims to evaluate the efficacy and larynx organ preservation of neoadjuvant treatment with PD-1 inhibitors in combination with paclitaxel (Albumin-bound) and cisplatin for locally advanced laryngeal and hypopharyngeal SCC. METHODS: Medical records of consecutive patients diagnosed with histologically or cytologically confirmed locally advanced SCC of the larynx and hypopharynx, who received PD-1 inhibitor therapy at a single tertiary care center, were reviewed from January 1, 2019, to December 15, 2022...
October 7, 2023: Cancer Immunology, Immunotherapy: CII
https://read.qxmd.com/read/37794575/delivery-of-re-irradiation-and-complex-palliative-radiotherapy-using-proton-therapy-in-pediatric-cancer-patients
#36
JOURNAL ARTICLE
Eva Berlin, Rachel Eisenberg, Christine Hill-Kayser, Robert A Lustig, Goldie Kurtz, Elizabeth Cummings, Michael LaRiviere
BACKGROUND: The intent of this study is to characterize indications for pediatric palliative-intent proton radiation therapy (PIPRT). PROCEDURE: We retrospectively reviewed patients 21 years and younger who received PIPRT. We defined PIPRT as radiotherapy (RT) aimed to improve cancer-related symptoms/provide durable local control in the non-curative setting. Mixed proton/photon plans were included. Adjacent re-irradiation (reRT) was defined as a reRT volume within the incidental dose cloud of a prior RT target, whereas direct reRT was defined as in-field overlap with prior RT target...
December 2023: Pediatric Blood & Cancer
https://read.qxmd.com/read/37786077/anatomy-guided-deep-learning-model-for-accurate-and-robust-gross-tumor-volume-segmentation-in-lung-cancer-radiation-therapy
#37
JOURNAL ARTICLE
P Wang, J Ge, D Zheng, X Zhu, J Liu, Y Wu, L Lu, S Yan, D Jin, X Ye
PURPOSE/OBJECTIVE(S): In lung cancer radiation therapy, clinicians must outline the gross tumor volume (GTV) precisely on the planning computed tomography (pCT) for accurate radiation dose delivery. However, due to the limited contrast between tumor and normal tissues in lung parenchyma, accurate delineation of tumor boundaries is difficult leading to large inter-observer variation. In this study, we develop an anatomy-guided lung GTV deep segmentation model using a training cohort of multi-center datasets...
October 1, 2023: International Journal of Radiation Oncology, Biology, Physics
https://read.qxmd.com/read/37773042/the-role-of-corticosteroids-in-the-palliation-of-dyspnea-in-cancer-patients-an-evidence-based-review
#38
JOURNAL ARTICLE
David Hui, Sriram Yennurajalingam
PURPOSE OF REVIEW: To provide an evidence-based review on the use of corticosteroids for dyspnea in cancer patients. RECENT FINDINGS: Corticosteroids are commonly used for palliation of dyspnea; however, there is wide variation in how they are prescribed due to the paucity of high-quality evidence. Some clinicians would offer corticosteroids routinely regardless of the causes of dyspnea, while others would only prescribe corticosteroids selectively for specific indications, such as lymphangitic carcinomatosis, upper airway obstruction, superior vena cava obstruction, and cancer treatment-induced pneumonitis...
September 29, 2023: Current Opinion in Supportive and Palliative Care
https://read.qxmd.com/read/37761254/utility-and-safety-of-bronchoscopic-cryotechniques-a-comprehensive-review
#39
REVIEW
Shaikh M Noor Husnain, Abhishek Sarkar, Taha Huseini
Cryosurgical techniques are employed for diagnostic and therapeutic bronchoscopy and serve as important tools for the management of pulmonary diseases. The diagnosis of interstitial lung disease requires multidisciplinary team discussions after a thorough assessment of history, physical exam, computed tomography, and lung-function testing. However, histological diagnosis is required in selected patients. Surgical lung biopsy has been the gold standard but this can be associated with increased morbidity and mortality...
September 8, 2023: Diagnostics
https://read.qxmd.com/read/37719298/all-in-one-properties-of-an-anticancer-covered-airway-stent-for-the-prevention-of-malignant-central-airway-obstruction
#40
JOURNAL ARTICLE
Zhaonan Li, Wenguang Zhang, Dechao Jiao, Chuan Tian, Kaihao Xu, Haidong Zhu, Xinwei Han
Malignant central airway obstruction (MCAO) resulting from tumor metastasis and compression severely impairs respiration, posing life-threatening risks. To address this, we employed a synergistic modification strategy, combining cisplatin (CIS) and silver nanoparticles (AgNPs). Polycaprolactone (PCL) served as a drug carrier, enabling the preparation of a functional CIS@AgNPs@PCL fiber membrane-covered airway stent via electrospinning. This approach aimed to enhance the patency rate of MCAO. Characterization via ATR-FTIR, scanning electron microscope-energy-dispersive spectroscopy, and transmission electron microscope confirmed successful immobilization of CIS and AgNPs onto the stent surface...
September 2023: APL Bioengineering
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