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Airway assessment cancer

Josef Yayan, Kurt Rasche
Cannabis is the most widely smoked illicit substance in the world. It can be smoked alone in its plant form, marijuana, but it can also be mixed with tobacco. The specific effects of smoking cannabis are difficult to assess accurately and to distinguish from the effects of tobacco; however its use may produce severe consequences. Cannabis smoke affects the lungs similarly to tobacco smoke, causing symptoms such as increased cough, sputum, and hyperinflation. It can also cause serious lung diseases with increasing years of use...
August 30, 2016: Advances in Experimental Medicine and Biology
Loni C Arrese, Ricardo Carrau, Emily K Plowman
The Eating Assessment Tool-10 (EAT-10) represents a validated, easy to administer patient report dysphagia severity scale. Although its ability to detect swallowing impairment has been investigated in other patient populations, the utility of this instrument in individuals with head and neck cancer (HNC) has not been studied. The aim of the current investigation was to determine the relationship between patient ratings of swallowing impairment (EAT-10) and objective clinical ratings of swallow physiology in individuals with HNC...
August 18, 2016: Dysphagia
Karan Gupta, Dushyant Mandlik, Daxesh Patel, Purvi Patel, Bankim Shah, Devanhalli G Vijay, Jagdish M Kothari, Rajendra B Toprani, Kaustubh D Patel
BACKGROUND: Tracheostomy is a mainstay modality for airway management for patients with head-neck cancer undergoing surgery. This study aims to define factors predicting need of tracheostomy and define an effective objective criterion to predict tracheostomy need. METHODS: 486 patients undergoing composite resections were studied. Factors analyzed were age, previous surgery, extent of surgery, trismus, extent of mandibular resection and reconstruction etc. Factors were divided into major and minor, using the clinical assessment scoring system for tracheostomy (CASST) criterion...
September 2016: Journal of Cranio-maxillo-facial Surgery
Stefan P Wesolowski, Piotr W Boros, Tadeusz M Orłowski, Philip H Quanjer
BACKGROUND: Impaired lung function (LF) is a well-known risk factor for perioperative complications in patients qualified for lung resection surgery. The recent European guidelines recommend using values below 80% predicted as indicating abnormal LF rather than the lower limit of normal (LLN). OBJECTIVES: To assess how the choice of a cut-off point (80% predicted vs. LLN at -1.645 SD) affects the incidence of functional disorders and postoperative complications in lung cancer patients referred for lung resection...
2016: Respiration; International Review of Thoracic Diseases
Takahiro Nakajima, Kazuhiro Yasufuku, Taiki Fujiwara, Ichiro Yoshino
Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is a minimally invasive modality for sampling of mediastinal and hilar lymph nodes as well as pulmonary lesions adjacent to the airway. Guidelines for staging of lung cancer suggest that EBUS-TBNA should be considered the best first test of nodal staging for radiologically abnormal lymph nodes that are accessible by this approach. The application of EBUS-TBNA in pulmonary medicine and thoracic oncology is expanding with its role in the diagnosis of sarcoidosis, lymphoma, and tuberculosis...
July 2016: Respiratory Investigation
Pei-Ming Huang, Jang-Ming Lee
BACKGROUND: To analyze the outcomes of single or dual luminal self-expandable covered metallic stents (SECMS) for palliative treatment for esophageal cancer with esophago-airway fistula (EAF). METHODS: We retrospectively assessed 50 patients who underwent SECMS placement for malignant EAF at our institution between June 2005 and December 2014 to define clinical results of stenting. Treatment provided was classified into initial single airway, single esophageal, or double stent placement...
July 13, 2016: Surgical Endoscopy
Esther Pompe, Pim A de Jong, Eva M van Rikxoort, Leticia Gallardo Estrella, Werner U de Jong, Rozemarijn Vliegenthart, Matthijs Oudkerk, Carlijn M van der Aalst, Bram van Ginneken, Jan-Willem J Lammers, Firdaus Aa Mohamed Hoesein
Osteoporosis is more common in patients with COPD and in smokers. The aim of this study was to assess whether measures of emphysema and airway disease on computed tomography (CT) were associated with lower bone density or vertebral fractures in smokers with and without COPD. For this purpose, we included participants from the NELSON lung cancer screening trial. Bone density was measured as Hounsfield Units in the first lumbar vertebra, and vertebral fractures were assessed semiquantitatively. The 15th percentile method (Perc15) was used to assess emphysema, and the airway lumen perimeter (Pi10) was used for airway wall thickness...
2016: International Journal of Chronic Obstructive Pulmonary Disease
Asude Ayhan, Serife Kaplan, Zeynep Kayhan, Gulnaz Arslan
The primary aim of this single center retrospective study was to evaluate difficult mask ventilation (DMV) and difficult laryngoscopy (DL) in a unique group of obese patients. A total of 427 adult patients with body mass index (BMI) ≥ 25 and surgically treated for endometrial cancer from 2011 to 2014 were assessed. Additional increase in BMI, comorbidities, bedside screening tests for risk factors, and the tools used to manage the patients were noted and their effects on DMV and/or DL investigated. Every escalation in the number of risk factors increased the probability of DMV 2...
March 2016: Acta Clinica Croatica
Gunnar Damgård Nielsen, Søren Thor Larsen, Peder Wolkoff
In 2010, the World Health Organization (WHO) established an indoor air quality guideline for short- and long-term exposures to formaldehyde (FA) of 0.1 mg/m(3) (0.08 ppm) for all 30-min periods at lifelong exposure. This guideline was supported by studies from 2010 to 2013. Since 2013, new key studies have been published and key cancer cohorts have been updated, which we have evaluated and compared with the WHO guideline. FA is genotoxic, causing DNA adduct formation, and has a clastogenic effect; exposure-response relationships were nonlinear...
May 21, 2016: Archives of Toxicology
Asuka Matsuzaki, Naozumi Hashimoto, Shotaro Okachi, Tetsuo Taniguchi, Koji Kawaguchi, Takayuki Fukui, Kenji Wakai, Kohei Yokoi, Yoshinori Hasegawa
BACKGROUND: Previously, it has been shown that using a fixed ratio of FEV1/FVC of 0.7 to classify airway obstruction could not predict survival outcomes in lung cancer patients undergoing thoracic surgery. We demonstrated that use of the lower limit of normal (LLN) of FEV1/FVC may allow better risk stratification for postoperative outcomes in patients with chronic obstructive pulmonary disease (COPD) patients. Nevertheless, it remained unclear whether survival outcomes in this population could be predicted by LLN-defined airway obstruction...
May 2016: Respiratory Investigation
Masumi Suzui, Mitsuru Futakuchi, Katsumi Fukamachi, Takamasa Numano, Mohamed Abdelgied, Satoru Takahashi, Makoto Ohnishi, Toyonori Omori, Shuji Tsuruoka, Akihiko Hirose, Jun Kanno, Yoshimitsu Sakamoto, David B Alexander, William T Alexander, Xu Jiegou, Hiroyuki Tsuda
Multiwalled carbon nanotubes (MWCNT) have a fibrous structure and physical properties similar to asbestos and have been shown to induce malignant mesothelioma of the peritoneum after injection into the scrotum or peritoneal cavity in rats and mice. For human cancer risk assessment, however, data after administration of MWCNT via the airway, the exposure route that is most relevant to humans, is required. The present study was undertaken to investigate the carcinogenicity of MWCNT-N (NIKKISO) after administration to the rat lung...
July 2016: Cancer Science
Fahrettin Talay, Mehmet Tosun, Zehra Asuk Yaşar, Özlem Kar Kurt, Aysel Karği, Serkan Öztürk, Mehmet Fatih Özlü, Aytekin Alçelik
Chronic obstructive pulmonary disease (COPD) represents a systemic disorder characterized by chronic airflow limitation and an increased inflammatory response of the airways. Comorbidities are frequent in COPD and it is crucial to predict these in early stage for adequate management of COPD. Recent studies have reported that elevated levels of pregnancy-associated plasma protein-A (PAPP-A), a zinc-binding metalloproteinase, detected in patients with asthma, lung cancer, and pulmonary embolism and independently associated with cardiovascular events...
June 2016: Inflammation
Livia Lamartina, S Ippolito, M Danis, F Bidault, I Borget, A Berdelou, A Al Ghuzlan, D Hartl, P Blanchard, M Terroir, D Deandreis, M Schlumberger, E Baudin, S Leboulleux
BACKGROUND: Antiangiogenic tyrosine kinase inhibitors (TKIs) are the mainstay of advanced thyroid cancer (TC) treatment. Concern is rising about TKI-related toxicity. OBJECTIVE: To determine the incidence and to investigate the risk factors of hemoptysis in TC patients during TKI treatment. METHODS: We analyzed consecutive TC patients treated with TKI in our center between 2005 and 2013 and performed an independent review of computed tomography scan images for airway invasion assessment...
July 2016: Journal of Clinical Endocrinology and Metabolism
Kirsten Lindner, Linda Lübbe, Ann-Kathrin Müller, Daniel Palmes, Norbert Senninger, Richard Hummel
Fistulas between the upper intestinal tract and the airway following esophagectomy are a rare and severe complication with significant mortality. Treatment and therapy are difficult and require a multidisciplinary approach. The objective of this retrospective study was to identify risk factors for these fistulas following esophagetcomy, and to assess their impact on the further clinical course and outcome. 211 patients undergoing Ivor-Lewis esophagectomy for esophageal cancer between 2005 and 2012 were included...
April 7, 2016: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
Urszula Kosikowska, Anna Biernasiuk, Paweł Rybojad, Renata Łoś, Anna Malm
BACKGROUND: Haemophili are representative microbiota of the upper respiratory tract. The aim of this study was to assess the effects of perioperative antimicrobial prophylaxis and/or postoperative treatment on Haemophilus parainfluenzae prevalence, and antimicrobial sensitivity in short-term hospitalized patients with lung cancer who underwent surgery. RESULTS: Samples were collected from 30 short-term hospitalized patients with lung cancer and from 65 healthy people...
2016: BMC Microbiology
Abu Bakar Hafeez Bhatti, Hassan Iqbal, Raza Hussain, Aamir Ali Syed, Arif Jamshed
Tracheotomy is commonly performed for the management of upper airway compromise. Trauma and head and neck cancers are the most frequent indications. The objective of this study was to share our experience with tracheotomy performed for a broad range of malignancies including but not limited to head and neck cancer. This study is a retrospective case series of patients who underwent tracheotomy from January 2004 to June 2012 at Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan. A total of 130 patients were included in the study...
December 2015: Indian Journal of Surgery
Ali Sarfraz Siddiqui, Samie Asghar Dogar, Shankar Lal, Shabbir Akhtar, Fauzia Anis Khan
BACKGROUND AND AIMS: General anesthesia and airway management of patients for head and neck cancer surgery is a challenge for the anesthesiologist. Appropriate assessment and planning are essential for successful airway management. Our objectives were to review airway management strategies in patients undergoing head and neck cancer surgery in our tertiary care institution and also to observe the effect of airway management techniques on postoperative length of hospital stay (PLOS). MATERIAL AND METHODS: A retrospective medical record review of 400 patients who underwent major head and neck cancer surgery in our institution was conducted...
January 2016: Journal of Anaesthesiology, Clinical Pharmacology
M Emura, M Aufderheide
Lung cancer is still one of the major intractable diseases and we urgently need more efficient preventive and curative measures. Recent molecular studies have provided strong evidence that allows us to believe that classically well-known early airway lesions such as hyperplasia, metaplasia, dysplasia and carcinoma in situ are really precancerous lesions progressing toward cancer but not necessarily transient and reversible alteration. This suggests that adequate early control of the precancerous lesions may lead to improved prevention of lung cancer...
May 2016: Experimental and Toxicologic Pathology: Official Journal of the Gesellschaft Für Toxikologische Pathologie
Sayaka Suzuki, Hideo Yasunaga, Hiroki Matsui, Kiyohide Fushimi, Yuki Saito, Tatsuya Yamasoba
To identify risk factors for post-thyroidectomy hematoma requiring airway intervention or surgery ("wound hematoma") and determine post-thyroidectomy time to intervention. Post-thyroidectomy hematoma is rare but potentially lethal. Information on wound hematoma in a nationwide clinical setting is scarce.Using the Japanese Diagnosis Procedure Combination database, we extracted data from records of patients undergoing thyroidectomy from July 2010 to March 2014. Patients with clinical stage IV cancer or those with bilateral neck dissection were excluded because they could have undergone planned tracheotomy on the day of thyroidectomy...
February 2016: Medicine (Baltimore)
Siegfried Wieshammer, Jens Dreyhaupt, Dirk Müller, Felix Momm, Andreas Jakob
BACKGROUND: Cancer patients are at increased risk for venous thromboembolism (VTE). OBJECTIVE: This monocenter cross-sectional study prospectively assessed the association between a history of ≥1 VTE episode and the presence of pulmonary hypertension (PH) among cancer patients presenting with pulmonary or cardiac symptoms. METHODS: A consecutive series of 583 patients underwent a diagnostic work-up for heart and lung disease. PH was diagnosed if a patient's peak systolic pressure gradient across the tricuspid valve was ≥35 mmHg, as measured by echocardiography...
2016: Thrombosis Journal
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