keyword
https://read.qxmd.com/read/38489115/modulation-of-t-cell-differentiation-in-mice-with-copd-combined-with-lung-cancer-through-key-targets-of-pd-1-by-tao-hong-si-wu-tang
#1
JOURNAL ARTICLE
Guoli Wang, Ge Wang, Keming Zhao, Aifeng Sui, Lina Wang, Yanling Xu, Nini Qu, Xiande Ma, Hu Deng
The objective is to assess the anti-inflammatory effect of Tao Hong Si Wu Tang combined with anti-PD-1 in a mouse model of COPD combined with lung cancer, elucidating its mechanism through modulation of PD-1/PD-L binding, regulation of Th1/Th2 and Th17/Treg balance, inhibition of IL-4 and IL-17, and promotion of IFN-γ and TGF-β levels in peripheral blood. One hundred male C57/BL6 mice were randomly allocated to five groups: A (blank control), B (model control), C (THSW), D (anti-PD-1), and E (THSW + anti-PD-1), with 20 mice in each group...
March 15, 2024: Applied Biochemistry and Biotechnology
https://read.qxmd.com/read/38460973/association-between-heated-tobacco-product-use-and-airway-obstruction-a-single-centre-observational-study-japan
#2
JOURNAL ARTICLE
Satomi Odani, Shihoko Koyama, Isao Miyashiro, Hironobu Tanigami, Yoshifumi Ohashi, Takahiro Tabuchi
BACKGROUND: While heated tobacco products (HTPs) may affect pulmonary function, the evidence supporting the utility of screening for HTP use in clinical settings is insufficient. We examined the association between HTP use and airway obstruction after switching from cigarettes. METHOD: The study subjects were patients aged ≥20 years undergoing surgery from December 2021 to September 2022 who completed spirometry and reported tobacco (cigarette and HTP) use status during the preoperative assessment...
March 9, 2024: BMJ Open Respiratory Research
https://read.qxmd.com/read/38452638/anesthetic-management-of-thyroid-carcinoma-invading-the-upper-tracheal-segment-a-case-report
#3
Yuyan Ding, Lianbing Gu, Lijun Wang, Lingxi Xing, Yihu Zhou, Yueyi Jiang
INTRODUCTION AND IMPORTANCE: Intratracheal tumors account for approximately 0.2 % of respiratory tumors, including primary and secondary tumors. Secondary tumors of the upper trachea are most commonly derived from advanced thyroid cancer. Surgical resection is currently the general curative modality for thyroid cancer with tracheal invasion. Patients with tracheal tumors invading and protruding into the lumen may have reduced oxygen reserve capacity, leading to a shorter safe window for general anesthesia induction...
February 27, 2024: International Journal of Surgery Case Reports
https://read.qxmd.com/read/38444662/centrilobular-emphysema-and-airway-dysanapsis-factors-associated-with-low-respiratory-function-in-younger-smokers
#4
JOURNAL ARTICLE
Fumi Mochizuki, Naoya Tanabe, Takafumi Shimada, Hiroaki Iijima, Ryo Sakamoto, Yusuke Shiraishi, Tomoki Maetani, Kaoruko Shimizu, Masaru Suzuki, Shotaro Chubachi, Hiroichi Ishikawa, Takashi Naito, Megumi Kanasaki, Izuru Masuda, Tsuyoshi Oguma, Susumu Sato, Nobuyuki Hizawa, Toyohiro Hirai
BACKGROUND: Low respiratory function in young adulthood is one of the important factors in the trajectory leading to the future development of COPD, but its morphological characteristics are not well characterised. METHODS: We retrospectively enrolled 172 subjects aged 40-49 years with ≥10 pack-years smoking history who underwent lung cancer screening by computed tomography (CT) and spirometry at two Japanese hospitals. Emphysema was visually assessed according to the Fleischner Society guidelines and classified into two types: centrilobular emphysema (CLE) and paraseptal emphysema (PSE)...
March 2024: ERJ Open Research
https://read.qxmd.com/read/38414192/airway-protection-and-outcomes-after-staged-versus-concurrent-bilateral-neck-dissections-with-transoral-base-of-tongue-cancer-resection
#5
JOURNAL ARTICLE
Jake J Lee, Nicholas A Rapoport, Patrik Pipkorn, Sidharth V Puram, Ryan S Jackson
OBJECTIVES: To assess airway, safety, and resource utilization outcomes between transoral base of tongue (BOT) surgery with staged versus concurrent bilateral neck dissections (BND). METHODS: A retrospective cohort study of patients with human papilloma virus (HPV)-related BOT cancer who underwent transoral surgery and BND from January 2015 through June 2022 was conducted. Free flap patients were excluded. RESULTS: Of 126 patients (46 [37%] staged and 80 [63%] concurrent BND), there were no significant differences in rates of postoperative intubation, tracheostomy, intensive care admission, operative takebacks, gastrostomy, and 30-day readmission...
February 27, 2024: Head & Neck
https://read.qxmd.com/read/38409078/differential-pulmonary-toxicity-and-autoantibody-formation-in-genetically-distinct-mouse-strains-following-combined-exposure-to-silica-and-diesel-exhaust-particles
#6
JOURNAL ARTICLE
Lisa Mf Janssen, Frauke Lemaire, Nora Fopke Marain, Steven Ronsmans, Natasja Heylen, Arno Vanstapel, Greetje Vande Velde, Jeroen Aj Vanoirbeek, Kenneth Michael Pollard, Manosij Ghosh, Peter Hm Hoet
BACKGROUND: Inhalation of airborne particulate matter, such as silica and diesel exhaust particles, poses serious long-term respiratory and systemic health risks. Silica exposure can lead to silicosis and systemic autoimmune diseases, while DEP exposure is linked to asthma and cancer. Combined exposure to silica and DEP, common in mining, may have more severe effects. This study investigates the separate and combined effects of occupational-level silica and ambient-level DEP on lung injury, inflammation, and autoantibody formation in two genetically distinct mouse strains, thereby aiming at understanding the interplay between genetic susceptibility, particulate exposure, and disease outcomes...
February 27, 2024: Particle and Fibre Toxicology
https://read.qxmd.com/read/38372643/association-between-airport-ultrafine-particles-and-lung-cancer-risk-the-multiethnic-cohort-study
#7
JOURNAL ARTICLE
Arthur Bookstein, Justine Po, Chiuchen Tseng, Timothy V Larson, Juan Yang, Sung-Shim L Park, Jun Wu, Salma Shariff-Marco, Pushkar P Inamdar, Ugonna Ihenacho, Veronica Wendy Setiawan, Mindy C DeRouen, Loïc Le Marchand, Daniel O Stram, Jonathan Samet, Beate Ritz, Scott Fruin, Anna H Wu, Iona Cheng
BACKGROUND: Ultrafine particles (UFPs) are unregulated air pollutants abundant in aviation exhaust. Emerging evidence suggests that UFPs may impact lung health due to their high surface area-to-mass ratio and deep penetration into airways. This study aimed to assess long-term exposure to airport-related UFPs and lung cancer incidence in a multiethnic population in Los Angeles County. METHODS: Within the California Multiethnic Cohort, we examined the association between long-term exposure to airport-related UFPs and lung cancer incidence...
February 19, 2024: Cancer Epidemiology, Biomarkers & Prevention
https://read.qxmd.com/read/38369388/medication-based-comorbidity-measures-and-prostate-cancer-treatment-selection
#8
JOURNAL ARTICLE
Tenaw Tiruye, Michael O'Callaghan, Liesel M FitzGerald, Kim Moretti, Alex Jay, Braden Higgs, Ganessan Kichenadasse, Gillian Caughey, David Roder, Kerri Beckmann
INTRODUCTION: We aimed to assess the association between comorbidities and prostate cancer management. PATIENTS AND METHODS: We studied 12,603 South Australian men diagnosed with prostate cancer between 2003 and 2019. Comorbidity was measured one year prior to prostate cancer diagnosis using a medication-based comorbidity index (Rx-Risk). Binomial logistic regression analyses were used to assess the association between comorbidities and primary treatment selection (active surveillance, radical prostatectomy (RP), external beam radiotherapy (EBRT) with or without androgen deprivation therapy (ADT), brachytherapy, ADT alone, and watchful waiting (WW))...
February 1, 2024: Clinical Genitourinary Cancer
https://read.qxmd.com/read/38337438/comorbidities-in-copd-current-and-future-treatment-challenges
#9
REVIEW
Domenica Francesca Mariniello, Vito D'Agnano, Donatella Cennamo, Stefano Conte, Gianluca Quarcio, Luca Notizia, Raffaella Pagliaro, Angela Schiattarella, Rosario Salvi, Andrea Bianco, Fabio Perrotta
Chronic obstructive pulmonary disease (COPD) is a heterogeneous lung condition, primarily characterized by the presence of a limited airflow, due to abnormalities of the airways and/or alveoli, that often coexists with other chronic diseases such as lung cancer, cardiovascular diseases, and metabolic disorders. Comorbidities are known to pose a challenge in the assessment and effective management of COPD and are also acknowledged to have an important health and economic burden. Local and systemic inflammation have been proposed as having a potential role in explaining the association between COPD and these comorbidities...
January 27, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38305501/diagnostic-value-of-systematic-bronchial-aspirate-on-postoperative-pneumonia-after-pulmonary-resection-surgery-for-lung-cancer-a-mono-center-retrospective-study
#10
JOURNAL ARTICLE
Olivier Georges, Osama Abou Arab, Malek Ben Rahal, Florence de Dominicis, Alejandro Witte Pfister, Geoni Merlusca, Jules Iquille, Pascal Berna
OBJECTIVES: Intraoperative bacterial airway colonization seems to be associated with an increased risk of postoperative pneumonia (POP). It can be easily assessed by performing a bronchial aspirate (BA). The objective of this study is to assess the diagnostic performance of the BA to predict POP. METHODS: We conducted a single-center retrospective observational study over a period of 10 years, from January 1st, 2011, to December 30th, 2020. The population study was patients admitted for a scheduled pulmonary resection surgery for lung cancer...
February 1, 2024: Interdiscip Cardiovasc Thorac Surg
https://read.qxmd.com/read/38300206/acr-lung-rads-v2022-assessment-categories-and-management-recommendations
#11
JOURNAL ARTICLE
Jared Christensen, Ashley Elizabeth Prosper, Carol C Wu, Jonathan Chung, Elizabeth Lee, Brett Elicker, Andetta R Hunsaker, Milena Petranovic, Kim L Sandler, Brendon Stiles, Peter Mazzone, David Yankelevitz, Denise Aberle, Caroline Chiles, Ella Kazerooni
The American College of Radiology created the Lung CT Screening Reporting and Data System (Lung-RADS) in 2014 to standardize the reporting and management of screen-detected pulmonary nodules. Lung-RADS was updated to version 1.1 in 2019 and revised size thresholds for nonsolid nodules, added classification criteria for perifissural nodules, and allowed for short-interval follow-up of rapidly enlarging nodules that may be infectious in etiology. Lung-RADS v2022, released in November 2022, provides several updates including guidance on the classification and management of atypical pulmonary cysts, juxtapleural nodules, airway-centered nodules, and potentially infectious findings...
January 29, 2024: Chest
https://read.qxmd.com/read/38276115/bronchial-progenitor-cells-in-obstructive-and-neoplastic-lung-disease-a-pilot-study
#12
JOURNAL ARTICLE
Beatrice Ragnoli, Federica Fusco, Patrizia Pignatti, Tiziana Cena, Guido Valente, Mario Malerba
The alteration of progenitor/stem cells present in the airway epithelium has been observed in patients with COPD. Smoking exposure induces remodeling patterns in bronchial progenitor cells (BPCs), encompassing squamous metaplasia, hyperplasia of basal and of mucus-secreting cells, and the depletion of ciliated and non-mucous secretory cells. Our aim was to assess the expression of p63 and vimentin as potential markers of airway remodeling and the regulation of stem cell populations in obstructive and neoplastic lung disease patients...
January 21, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38263898/allergooncology-biomarkers-and-refined-classification-for-research-in-the-allergy-and-glioma-nexus-a-joint-eaaci-eano-position-paper
#13
JOURNAL ARTICLE
Michelle C Turner, Urszula Radzikowska, Denisa E Ferastraoaru, Mariona Pascal, Pieter Wesseling, Alexandra McCraw, Claudine Backes, Heather J Bax, Christoph Bergmann, Rodolfo Bianchini, Luigi Cari, Leticia de Las Vecillas, Elena Izquierdo, Frida Lind-Holm Mogensen, Alessandro Michelucci, Petr V Nazarov, Simone P Niclou, Giuseppe Nocentini, Markus Ollert, Matthias Preusser, Nataliya Rohr-Udilova, Andrea Scafidi, Reka Toth, Mieke Van Hemelrijck, Michael Weller, Uta Jappe, Maria M Escribese, Erika Jensen-Jarolim, Sophia N Karagiannis, Aurélie Poli
Epidemiological studies have explored the relationship between allergic diseases and cancer risk or prognosis in AllergoOncology. Some studies suggest an inverse association, but uncertainties remain, including in IgE-mediated diseases and glioma. Allergic disease stems from a Th2-biased immune response to allergens in predisposed atopic individuals. Allergic disorders vary in phenotype, genotype and endotype, affecting their pathophysiology. Beyond clinical manifestation and commonly used clinical markers, there is ongoing research to identify novel biomarkers for allergy diagnosis, monitoring, severity assessment and treatment...
January 24, 2024: Allergy
https://read.qxmd.com/read/38234342/successful-one-lung-ventilation-in-a-patient-after-laryngectomy-by-inserting-a-long-spiral-single-lumen-tube-into-the-left-main-bronchus-a-case-report
#14
Emi Imai, Masataka Fukuda, Tsukasa Kochiyama, Ai Yamaguchi, Yusuke Sugasawa, Masakazu Hayashida, Izumi Kawagoe
BACKGROUND: Patients who have had laryngectomy require a thorough preoperative assessment for potential stomal stenosis, and an action plan for possible inadvertent displacement of the voice prosthesis (VP) must be considered. We report the anesthetic management of a post-laryngectomy patient undergoing lung resection surgery. The patient had both a laryngectomy and a VP in situ . CASE DESCRIPTION: A 66-year-old man with Parkinson's disease, who had previously undergone total laryngectomy for supraglottic laryngeal cancer, had a cuffed tracheostomy tube and a VP inserted into the tracheoesophageal fistula below it...
2024: AME Case Reports
https://read.qxmd.com/read/38175360/presentation-of-hypoparathyroidism-in-italy-a-nationwide-register-based-study
#15
JOURNAL ARTICLE
C Cipriani, J Pepe, L Colangelo, M Cilli, L Nieddu, S Minisola
PURPOSE: We sought to assess the clinical presentation of hypoparathyroidism (HypoPT) in Italy. METHODS: We performed a nationwide study retrieving data from the hospital discharge ICD-9 codes database of the Italian Health Ministry, from 2007 through 2017. The codes corresponding to diagnosis of cardiovascular disease, cancer, infection, renal failure, psychiatric disease, upper airway tract infection and pneumonia, seizures, nephrolithiasis, cognitive impairment, cerebral calcifications, skin disorders, fracture, and cataract were retrieved when associated with the diagnosis of HypoPT (252...
January 4, 2024: Journal of Endocrinological Investigation
https://read.qxmd.com/read/38163953/identification-of-candidate-mrna-genes-and-their-potential-microrna-targets-in-lung-cancer-induced-by-smoking-tobacco
#16
JOURNAL ARTICLE
Amresh Kumar Mishra, Neha Mumtaz, Maneesh Kumar Misra
BACKGROUND: Smoking is considered the single highest risk factor for lung cancer and has been suggested to be associated with accelerated somatic mutations in respiratory mucosa that lead to the development of lung cancer. MicroRNAs serve as modulators in smoking-induced mRNA gene expression changes in the human airway epithelium and are linked to the development of lung cancer. The thermodynamics in the microRNA (miRNA)-mRNA interactions may be affected in tobacco smokers, consequently, leading to phenotypic variations in lung cancer patients...
November 27, 2023: Frontiers in Bioscience (Scholar Edition)
https://read.qxmd.com/read/38162050/-relationship-between-dynamic-compliance-and-airway-resistance-and-infection-indicators-in-elderly-patients-with-lung-infection-after-radiotherapy-for-esophageal-cancer
#17
JOURNAL ARTICLE
Zhaoxia Tian, Weiwei Tian, Hongmei Li, Xiaoyan Xue, Na Zhao
OBJECTIVE: To investigate the performance of using lung dynamic compliance (Cdyn) and airway resistance (RAW) levels to predict lung infection in elderly esophageal cancer patients who have undergone radiotherapy. METHODS: A total of 298 elderly esophageal cancer patients who received radiotherapy at Shanxi Fenyang Hospital between October 2017 and July 2022 were retrospectively enrolled and their clinical data were collected. The patients were divided into an infection group (124 cases) and a non-infection group (174 cases) according to their status of lung infection...
November 20, 2023: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
https://read.qxmd.com/read/38152085/epithelial-mesenchymal-transition-changes-in-nonsmall-cell-lung-cancer-patients-with-early-copd
#18
JOURNAL ARTICLE
Wenying Lu, Mathew Suji Eapen, Ashutosh Hardikar, Collin Chia, Iain Robertson, Gurpreet Kaur Singhera, Tillie L Hackett, Sukhwinder Singh Sohal
BACKGROUND: Epithelial-mesenchymal transition (EMT) might be central to lung cancer development in smokers and COPD. We illustrate EMT changes in a broader demographic of patient groups who were diagnosed with nonsmall cell lung cancer (adenocarcinoma and squamous cell carcinoma). These included COPD current and ex-smokers, patients with small airway disease and normal lung function smokers compared to normal controls. METHODS: We had access to surgically resected small airway tissue from 46 subjects and assessed for airway wall thickness and immunohistochemically for the EMT biomarkers E-cadherin, N-cadherin, S100A4, vimentin and epidermal growth factor receptor (EGFR)...
November 2023: ERJ Open Research
https://read.qxmd.com/read/38148054/association-between-clinicopathological-parameters-and-s100a8-a9-expression-according-to-smoking-history-in-patients-with-non-small-cell-lung-cancer
#19
JOURNAL ARTICLE
Sung Bae Cho, In Kyoung Kim, Chang Dong Yeo, Sang Haak Lee
BACKGROUND/AIM: Lung cancer is a major cause of cancer-related deaths worldwide, and chronic inflammation caused by cigarette smoke plays a crucial role in the development and progression of this disease. S100A8/9 and RAGE are associated with chronic inflammatory diseases and cancer. This study aimed to investigate the expression of S100A8/9, HMBG1, and other related pro-inflammatory molecules and clinical characteristics in patients with non-small cell lung cancer (NSCLC). PATIENTS AND METHODS: We obtained serum and bronchoalveolar lavage (BAL) fluid samples from 107 patients and categorized them as never or ever-smokers...
2024: In Vivo
https://read.qxmd.com/read/38143955/pulmonary-immune-related-adverse-events-of-pd-1-versus-pd-l1-checkpoint-inhibitors-a-retrospective-review-of-pharmacovigilance
#20
JOURNAL ARTICLE
Ugochi Ebinama, Ajay Sheshadri, Kartik Anand, Iyer Swaminathan
INTRODUCTION: Immune checkpoint inhibitors (ICIs) have revolutionized cancer therapeutics. However, immune-related adverse events (irAEs) increase morbidity and mortality and thereby limit therapeutic utility. The real-world incidence of the entire spectrum of pulmonary irAEs has not been systematically described. The objective of this study is to assess the risk of developing pulmonary irAEs (pneumonitis, pleural events [i.e., effusion and pleurisy], exacerbations of airway disease [i...
November 2023: Journal of immunotherapy and precision oncology
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