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Airway assessment cancer

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https://www.readbyqxmd.com/read/29659420/needle-based-optical-coherence-tomography-to-guide-transbronchial-lymph-node-biopsy
#1
Eugene Shostak, Lida P Hariri, George Z Cheng, David C Adams, Melissa J Suter
BACKGROUND: Transbronchial needle aspiration (TBNA), often used to sample lymph nodes for lung cancer staging, is subject to sampling error even when performed with endobronchial ultrasound. Optical coherence tomography (OCT) is a high-resolution imaging modality that rapidly generates helical cross-sectional images. We aim to determine if needle-based OCT can provide microstructural information in lymph nodes that may be used to guide TBNA, and improve sampling error. METHODS: We performed ex vivo needle-based OCT on thoracic lymph nodes from patients with and without known lung cancer...
April 13, 2018: Journal of Bronchology & Interventional Pulmonology
https://www.readbyqxmd.com/read/29628082/epithelial-mesenchymal-transition-effect-of-fine-particulate-matter-from-the-yangtze-river-delta-region-in-china-on-human-bronchial-epithelial-cells
#2
Yulang Chi, Qiansheng Huang, Yi Lin, Guozhu Ye, Huimin Zhu, Sijun Dong
Epidemiological studies have demonstrated that fine particulate matter (PM2.5 ) exposure causes airway inflammation, which may lead to lung cancer. The activation of epithelial-mesenchymal transition (EMT) is assumed to be a crucial step in lung tumor metastasis and development. We assessed the EMT effect of low concentrations (0, 0.1, 1.0, and 5.0μg/mL) of PM2.5 organic extract on a human bronchial epithelial cell line (BEAS-2B). PM2.5 samples were collected from three cities (Shanghai, Ningbo, and Nanjing) in the Yangtze River Delta (YRD) region in autumn 2014...
April 2018: Journal of Environmental Sciences (China)
https://www.readbyqxmd.com/read/29598944/three-dimensional-imaging-assessment-of-anatomic-invasion-and-volumetric-considerations-for-chemo-radiotherapy-based-laryngeal-preservation-in-t3-larynx-cancer
#3
Mona Kamal, Sweet Ping Ng, Salman A Eraj, Crosby D Rock, Brian Pham, Jay A Messer, Adam S Garden, William H Morrison, Jack Phan, Steven J Frank, Adel K El-Naggar, Jason M Johnson, Lawrence E Ginsberg, Renata Ferrarotto, Jan S Lewin, Katherine A Hutcheson, Carlos E Cardenas, Mark E Zafereo, Stephen Y Lai, Amy C Hessel, Randal S Weber, G Brandon Gunn, Clifton D Fuller, Abdallah S R Mohamed, David I Rosenthal
OBJECTIVES: To investigate the impact of 3-Diminsional (3D) tumor volume (TV) and extent of involvement of primary tumor on treatment outcomes in a large uniform cohort of T3 laryngeal carcinoma patients treated with nonsurgical laryngeal preservation strategies. MATERIALS AND METHODS: The pretreatment contrast-enhanced computed tomography images of 90 patients with T3 laryngeal carcinoma were reviewed. Primary gross tumor volume (GTVp) was delineated to calculate the 3D TV and define the extent of invasion...
April 2018: Oral Oncology
https://www.readbyqxmd.com/read/29548630/sleep-apnea-morbidity-a-consequence-of-microbial-immune-cross-talk
#4
REVIEW
Nuria Farré, Ramon Farré, David Gozal
Obstructive Sleep Apnea (OSA) has emerged as a highly prevalent public health problem that imposes important mid-term and long-term consequences, namely cardiovascular, metabolic, cognitive and cancer-related alterations. OSA is characterized by increased upper airway resistance, alveolar hypoventilation, and recurrent upper airway obstruction during sleep. Recurrent collapse of the upper airway develops with sleep onset, and is associated with both intermittent hypoxemia and sleep fragmentation. The microbiome is a vast and complex polymicrobial ecosystem that coexists with the human organism, and has been identified as playing significant roles in the development of host immunological phenotypes...
March 13, 2018: Chest
https://www.readbyqxmd.com/read/29477113/traditional-and-novel-halogenated-flame-retardants-in-urban-ambient-air-gas-particle-partitioning-size-distribution-and-health-implications
#5
A de la Torre, B Barbas, P Sanz, I Navarro, B Artíñano, M A Martínez
Urban ambient air samples, including gas-phase (PUF), total suspended particulates (TSP), PM10 , PM2.5 and PM1 airborne particle fractions were collected to evaluate gas-particle partitioning and size particle distribution of traditional and novel halogenated flame retardants. Simultaneously, passive air samplers (PAS) were deployed in the same location. Analytes included 33 polybrominated diphenyl ether (PBDE), 2,2',4,4',5,5'-hexabromobiphenyl (BB-153), hexabromobenzene (HBB), pentabromoethylbenzene (PBEB), 1,2-bis(2,4,6-tribromophenoxy)ethane (BTBPE), decabromodiphenyl ethane (DBDPE), dechloranes (Dec 602, 603, 604, 605 or Dechorane plus (DP)) and chlordane plus (CP)...
February 21, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29463557/the-airway-transcriptome-as-a-biomarker-for-early-lung-cancer-detection
#6
Ehab Billatos, Jessica L Vick, Marc E Lenburg, Avrum E Spira
Lung cancer remains the leading cause of cancer-related death due to its advanced stage at diagnosis. Early detection of lung cancer can be improved by better defining who should be screened radiographically, and determining which imaging-detected pulmonary nodules are malignant. Gene expression biomarkers measured in normal-appearing airway epithelium provide an opportunity to use lung cancer associated molecular changes in this tissue for early detection of lung cancer. Molecular changes in the airway may result from an etiologic field of injury and/or field cancerization...
February 20, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29437466/gene-promoter-hypermethylation-detected-in-sputum-predicts-fev1-decline-and-all-cause-mortality-in-smokers
#7
Shuguang Leng, Brenda Diergaarde, Maria A Picchi, David O Wilson, Frank D Gilliland, Jian-Min Yuan, Jill M Siegfried, Steven A Belinsky
RATIONALE: Gene promoter hypermethylation detected in sputum assesses the extent of field cancerization and predicts lung cancer (LC) risk in ever smokers. A rapid decline of forced expiratory volume in 1 second (FEV1) is a major driver for development of airway obstruction. OBJECTIVES: To assess the effects of methylation of 12 genes on FEV1 decline and of FEV1 decline on subsequent LC incidence using two independent, longitudinal cohorts (i.e., Lovelace Smokers cohort [LSC] and Pittsburgh Lung Screening Study [PLuSS])...
February 13, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29423747/relationship-between-swallowing-related-quality-of-life-and-fiberoptic-endoscopic-evaluation-of-swallowing-in-patients-who-underwent-open-partial-horizontal-laryngectomy
#8
Nicole Pizzorni, Antonio Schindler, Marco Fantini, Andy Bertolin, Giuseppe Rizzotto, Federico Ambrogi, Giovanni Succo, Erika Crosetti
BACKGROUND: Several studies have previously analyzed the relationship between QOL and signs of dysphagia in patients treated for head and neck cancer and have reported heterogeneous findings. To the best of our knowledge, no study has previously investigated this relationship among patients who underwent open partial horizontal laryngectomy (OPHL). The aim of the study is to determine if patient-reported swallowing-related QOL can discriminate between safe and unsafe swallowing in OPHL patients...
February 8, 2018: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29358001/catheter-based-endobronchial-electroporation-is-feasible-for-the-focal-treatment-of-peribronchial-tumors
#9
Hiroshi Kodama, Laurien G Vroomen, Eisuke Ueshima, Jennifer Reilly, Whitney Brandt, Lee-Ronn Paluch, Sebastien Monette, David Jones, Stephen B Solomon, Govindarajan Srimathveeravalli
OBJECTIVE: To evaluate the feasibility of catheter-based endobronchial electroporation for the treatment of peribronchial tumors and assess the incidence of treatment-related adverse events. METHODS: Cytotoxicity of electroporation with or without cisplatin or gefitinib was assessed in vitro with lung cancer and normal cell lines. A novel catheter was designed for endobronchial electroporation, and computer simulations were used to predict in vivo treatment effects...
May 2018: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29304175/genome-scale-metabolic-models-as-tools-for-drug-design-and-personalized-medicine
#10
Vytautas Raškevičius, Valeryia Mikalayeva, Ieva Antanavičiūtė, Ieva Ceslevičienė, Vytenis Arvydas Skeberdis, Visvaldas Kairys, Sergio Bordel
In this work we aim to show how Genome Scale Metabolic Models (GSMMs) can be used as tools for drug design. By comparing the chemical structures of human metabolites (obtained using their KEGG indexes) and the compounds contained in the DrugBank database, we have observed that compounds showing Tanimoto scores higher than 0.9 with a metabolite, are 29.5 times more likely to bind the enzymes metabolizing the considered metabolite, than ligands chosen randomly. By using RNA-seq data to constrain a human GSMM it is possible to obtain an estimation of its distribution of metabolic fluxes and to quantify the effects of restraining the rate of chosen metabolic reactions (for example using a drug that inhibits the enzymes catalyzing the mentioned reactions)...
2018: PloS One
https://www.readbyqxmd.com/read/29277176/-establishment-and-optimization-of-enhanced-recovery-after-surgery-system-for-lung-cancer
#11
Guowei Che
With the development of key techniques and programs, the concept of enhanced recovery after surgery (ERAS) has been utilized in a wide range of diseases and surgical specialties. The key technological elements of enhanced lung recovery after surgery (ELRAS), which is regarded as the mainstay of minimally invasive lung cancer surgery, consist of the airway management and the lung protection. A multidisciplinary team cooperation based on physicians, nurses and rehabilitative therapists is needed to achieve the goals of airway management and lung protection, thus establishing a comprehensive ELRAS system for lung cancer patients...
December 20, 2017: Zhongguo Fei Ai za Zhi, Chinese Journal of Lung Cancer
https://www.readbyqxmd.com/read/29214067/malignant-central-airway-obstruction
#12
REVIEW
Lakshmi Mudambi, Russell Miller, George A Eapen
This review comprehensively describes recent advances in the management of malignant central airway obstruction (CAO). Malignant CAO can be a dramatic and devastating manifestation of primary lung cancer or metastatic disease. A variety of diagnostic modalities are available to provide valuable information to plan a therapeutic intervention. Clinical heterogeneity in the presentation of malignant CAO provides opportunities to adapt and utilize endoscopic technology and tools in many ways. Mechanical debulking, thermal tools, cryotherapy and airway stents are methods and instruments used to rapidly restore airway patency...
September 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29187726/expression-of-interleukin-27-il-27-in-the-lower-airways-diseases-increased-levels-of-il-27-in-early-clinical-stages-of-non-small-cell-lung-cancer-nsclc-patients
#13
Piotr Kopiński, Tomasz Wandtke, Andrzej Dyczek, Ewelina Wędrowska, Adriana Roży, Tomasz Senderek, Grzegorz Przybylski, Joanna Chorostowska-Wynimko
INTRODUCTION    Interleukin-27, is a cytokine secreted mostly by antigen presenting cells, key for the Th1 cells immune polarization. Its role in interstitial lung diseases (ILD) as well as in lung cancer has been investigated.  OBJECTIVES    Assessment of IL-27 expression in the lower airways of patients with selected ILD and early-stage non-small cell lung cancer (NSCLC).  PATIENTS AND METHODS    IL-27 concentration was examined by ELISA in bronchoalveolar lavage (BAL) supernatants collected from patients with pulmonary sarcoidosis (PS), extrinsic allergic alveolitis (EAA), idiopathic pulmonary fibrosis (IPF), nonspecific interstitial pneumonia (NSIP) and I-IIa NSCLC with peripheral localization, as well as in control subjects (n = 14, 30, 12, 14, 16 and 14, respectively)...
November 29, 2017: Polish Archives of Internal Medicine
https://www.readbyqxmd.com/read/29039225/toxicological-impact-of-waterpipe-smoking-and-flavorings-in-the-oral-cavity-and-respiratory-system
#14
Fawad Javed, Shatha Subhi ALHarthi, Munerah Saleh BinShabaib, Sangeeta Gajendra, Georgios E Romanos, Irfan Rahman
Waterpipe smoking (WS), an emerging trend has major health concerns. It is prevalent worldwide as a recreational activity both indoors and outdoors. The aim of this review was to assess the impact of waterpipe smoke on the oral and respiratory system (oral cavity and pulmonary tissues). A number of studies have shown that periodontal health status is compromised in waterpipe smokers when compared with nonsmokers. Some studies have associated WS with oral premalignant and malignant lesions; however, due to the poor quality of these studies, the presented outcomes should be interpreted with caution...
August 2017: Inhalation Toxicology
https://www.readbyqxmd.com/read/29031119/index-analysis-and-human-health-risk-model-application-for-evaluating-ambient-air-heavy-metal-contamination-in-chemical-valley-sarnia
#15
Richard Olawoyin, Linda Schweitzer, Kuangyuan Zhang, Oladapo Okareh, Kevin Slates
The impacts of air emissions as a consequence of industrial activities around communities of human habitation have been extensively reported. This study is the first to assess potential adverse human health effects in the Chemical Valley Sarnia (CVS) area, around the St. Clair River, using health risk models, ecological and pollution indices. Large quantities of particulate matters (PM) are generated from anthropogenic activities, which contain several heavy metals in trace quantities with potentially adverse effects to humans and environmental health...
February 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28981500/optical-coherence-tomography-for-identification-and-quantification-of-human-airway-wall-layers
#16
Julia N S d'Hooghe, Annika W M Goorsenberg, Daniel M de Bruin, Joris J T H Roelofs, Jouke T Annema, Peter I Bonta
BACKGROUND: High-resolution computed tomography has limitations in the assessment of airway wall layers and related remodeling in obstructive lung diseases. Near infrared-based optical coherence tomography (OCT) is a novel imaging technique that combined with bronchoscopy generates highly detailed images of the airway wall. The aim of this study is to identify and quantify human airway wall layers both ex-vivo and in-vivo by OCT and correlate these to histology. METHODS: Patients with lung cancer, prior to lobectomy, underwent bronchoscopy including in-vivo OCT imaging...
2017: PloS One
https://www.readbyqxmd.com/read/28940774/functional-airway-obstruction-observed-with-hyperpolarized-129-xenon-mri
#17
Erin J Song, Chris R Kelsey, Bastiaan Driehuys, Leith Rankine
Hyperpolarized (129) Xenon-MRI (HP (129) Xe MRI) is an emerging imaging modality that allows assessment of both ventilation and gas transfer. Most research to date has focused on non-malignant pulmonary diseases. However, the capability of evaluating the two primary physiological processes of the lung (ventilation and gas transfer) makes HP (129) Xe MRI a promising imaging modality in the management of patients with lung cancer.
September 22, 2017: Journal of Medical Imaging and Radiation Oncology
https://www.readbyqxmd.com/read/28900521/effectiveness-of-ultrasonography-and-computed-tomography-in-assessing-thyroid-cartilage-invasion-in-laryngeal-and-hypopharyngeal-cancers
#18
Nilu Malpani Dhoot, B Choudhury, A C Kataki, L Kakoti, S Ahmed, J Sharma
OBJECTIVE: To evaluate the adequacy of ultrasonography (US) and computed tomography (CT) in the assessment of thyroid cartilage invasion in patients with airway cancer. MATERIALS AND METHODS: Sixty-two consecutive patients referred to our institute underwent US and CT to stage laryngeal (n = 27) or hypopharyngeal (n = 35) cancer in this prospective study. Two radiologists, who were blinded to the patients' clinical histories and histopathology, evaluated thyroid cartilage invasion on US and CT separately and independently...
September 2017: Journal of Ultrasound
https://www.readbyqxmd.com/read/28890556/ethnicity-and-upper-airway-measurements-a-study-in-south-indian-population
#19
Kalpana P Balakrishnan, Punitha A Chockalingam
BACKGROUND AND AIMS: Most studies on upper airway are conducted based on airway measurements in the western population. We set out to find the normal values of upper airway measurements in South Indian population. The aim of this study was to perform various upper airway examinations and to set standards for normal measurements in the South Indian population as well as to analyse the data for predictors of difficult intubation. METHODS: This prospective observational study was conducted in a tertiary cancer hospital in Southern India...
August 2017: Indian Journal of Anaesthesia
https://www.readbyqxmd.com/read/28843492/effects-of-gasoline-and-ethanol-gasoline-exhaust-exposure-on-human-bronchial-epithelial-and-natural-killer-cells-in-vitro
#20
Michèle Roth, Jakob Usemann, Christoph Bisig, Pierre Comte, Jan Czerwinski, Andreas C R Mayer, Konstantin Beier, Barbara Rothen-Rutishauser, Philipp Latzin, Loretta Müller
Air pollution exposure, including passenger car emissions, may cause substantial respiratory health effects and cancer death. In western countries, the majority of passenger cars are driven by gasoline fuel. Recently, new motor technologies and ethanol fuels have been introduced to the market, but potential health effects have not been thoroughly investigated. We developed and verified a coculture model composed of bronchial epithelial cells (ECs) and natural killer cells (NKs) mimicking the human airways to compare toxic effects between pure gasoline (E0) and ethanol-gasoline-blend (E85, 85% ethanol, 15% gasoline) exhaust emitted from a flexfuel gasoline car...
December 2017: Toxicology in Vitro: An International Journal Published in Association with BIBRA
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