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Plasma Mir

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https://www.readbyqxmd.com/read/29352517/mirna-binding-site-variants-of-type-2-diabetes-candidate-loci-predispose-to-gestational-diabetes-mellitus-in-chinese-han-women
#1
Xiaojing Wang, Wei Li, Liangkun Ma, Fan Ping, Juntao Liu, Xueyan Wu, Jiangfeng Mao, Xi Wang, Min Nie
AIMS/INTRODUCTION: Emerging evidence suggested that the genetic background of GDM was analogous to T2DM. In contrast to T2DM, the genetic studies for GDM were limited. Accordingly, the aim of this study was to extensively explore the influence of miR-binding-SNPs in T2DM candidate loci on GDM susceptibility in Chinese. METERIALS AND METHODS: A total of 839 GDM and 900 controls were enrolled. Six miR-binding-SNPs were selected from 30 T2DM susceptibility loci and genotyped using TaqMan allelic discrimination assays...
January 20, 2018: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/29345051/mir-595-suppresses-the-cellular-uptake-and-cytotoxic-effects-of-methotrexate-by-targeting-slc19a1-in-cem-c1-cells
#2
Shu-Mei Wang, Lu-Lu Sun, Wan-Shui Wu, Dan Yan
The human solute carrier family 19 member 1 (SLC19A1) is the gene coding for reduced folate carrier 1 (RFC1). In our previous work, we showed that the miR-595-related polymorphism, rs1051296 G>T, which was located in the 3'-untranslated region (3'-UTR) of SLC19A1, was associated with high methotrexate (MTX) plasma concentrations in pediatric acute lymphoblastic leukaemia (ALL) patients. The present study aimed to investigate the role of miR-595 in the regulation of SLC19A1 expression and its effects on the cellular uptake and cytotoxicity of MTX in ALL CEM/C1 cells...
January 17, 2018: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/29344661/plasma-levels-of-microrna-21-126-and-423-5p-alter-during-clinical-improvement-and-are-associated-with-the-prognosis-of-acute-heart-failure
#3
Stéfanie Ingrid Dos Reis Schneider, Daiane Silvello, Nidiane Carla Martinelli, Arthur Garbin, Andréia Biolo, Nadine Clausell, Michael Andrades, Kátia Gonçalves Dos Santos, Luís Eduardo Rohde
MicroRNAs are associated with myocardial damage and heart failure (HF). The present study investigated whether the plasma levels of microRNA (miR)‑21, ‑126 and ‑423‑5p alter according to the (de)compensated state of patients with HF and are associated with all‑cause mortality. In 48 patients with HF admitted to the emergency room for an episode of acute decompensation, blood samples were collected to measure miR and B‑type natriuretic peptide levels within 24 h of hospital admission, at the time of hospital discharge, and a number of weeks post‑discharge (chronic stable compensated state)...
January 15, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29344346/characterization-and-selective-incorporation-of-small-non-coding-rnas-in-non-small-cell-lung-cancer-extracellular-vesicles
#4
Chuang Li, Fang Qin, Fen Hu, Hui Xu, Guihong Sun, Guang Han, Tao Wang, Mingxiong Guo
Background: Extracellular vesicles (EVs) play important roles in intercellular communication through the delivery of their cargoes, which include proteins, lipids, and RNAs. Increasingly, multiple studies have reported the association between EV small non-coding RNAs and cancer, due to their regulatory functions in gene expression. Hence, analysis of the features of small non-coding RNA expression and their incorporation into EVs is important for cancer research. Results: We performed deep sequencing to investigate the expression of small RNAs in plasma EVs from lung adenocarcinoma (ADC) patients, lung squamous cell carcinoma (SQCC) patients, and healthy controls...
2018: Cell & Bioscience
https://www.readbyqxmd.com/read/29342969/feature-fusion-of-icp-aes-uv-vis-and-ft-mir-for-origin-traceability-of-boletus-edulis-mushrooms-in-combination-with-chemometrics
#5
Luming Qi, Honggao Liu, Jieqing Li, Tao Li, Yuanzhong Wang
Origin traceability is an important step to control the nutritional and pharmacological quality of food products. Boletus edulis mushroom is a well-known food resource in the world. Its nutritional and medicinal properties are drastically varied depending on geographical origins. In this study, three sensor systems (inductively coupled plasma atomic emission spectrophotometer (ICP-AES), ultraviolet-visible (UV-Vis) and Fourier transform mid-infrared spectroscopy (FT-MIR)) were applied for the origin traceability of 192 mushroom samples (caps and stipes) in combination with chemometrics...
January 15, 2018: Sensors
https://www.readbyqxmd.com/read/29340099/a-plasma-mirna-signature-for-lung-cancer-early-detection
#6
Qixin Leng, Yanli Lin, Fangran Jiang, Cheng-Ju Lee, Min Zhan, HongBin Fang, Yue Wang, Feng Jiang
The early detection of lung cancer continues to be a major clinical challenge. Using whole-transcriptome next-generation sequencing to analyze lung tumor and the matched noncancerous tissues, we previously identified 54 lung cancer-associated microRNAs (miRNAs). The objective of this study was to investigate whether the miRNAs could be used as plasma biomarkers for lung cancer. We determined expressions of the lung tumor-miRNAs in plasma of a development cohort of 180 subjects by using reverse transcription PCR to develop biomarkers...
December 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29339719/mir-181a-5p-suppresses-invasion-and-migration-of-htr-8-svneo-cells-by-directly-targeting-igf2bp2
#7
Liang Wu, Wen-Yan Song, Ya Xie, Lin-Li Hu, Xiao-Man Hou, Rui Wang, Yang Gao, Jing-Na Zhang, Le Zhang, Wei-Wei Li, Cheng Zhu, Zhi-Ying Gao, Ying-Pu Sun
Pre-eclampsia is a pregnancy-related disease that may cause maternal, neonatal and fetal morbidity and mortality and exists in 3-5% of pregnancies worldwide. The discovery of dysregulated microRNAs and their roles in placental development has provided a new avenue for elucidating the mechanism involved in this pregnancy-specific disorder. Here, the roles of human miR-181a-5p, a microRNA that is increased in both the plasma and placenta of severe pre-eclamptic patients, in invasion and migration of trophoblasts were investigated...
January 16, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29338015/exercise-induced-circulating-microrna-changes-in-athletes-in-various-training-scenarios
#8
Martin Horak, Filip Zlamal, Robert Iliev, Jan Kucera, Jan Cacek, Lenka Svobodova, Zuzana Hlavonova, Tomas Kalina, Ondrej Slaby, Julie Bienertova-Vasku
BACKGROUND: The aim of the study was to compare selected extracellular miRNA levels (miR-16, miR-21, miR-93 and miR-222 with the response to 8-week-long explosive strength training (EXPL), hypertrophic strength training (HYP) and high-intensity interval training (HIIT). METHODS: 30 young male athletes of white European origin (mean age: 22.5 ± 4.06 years) recruited at the Faculty of Sports Studies of Masaryk University were enrolled in this study. The study participants were randomly assigned to three possible training scenarios: EXPL, HYP or HITT and participated in 8-week-long program in given arm...
2018: PloS One
https://www.readbyqxmd.com/read/29332918/plasmatic-microrna-signatures-in-elderly-people-with-stable-and-unstable-angina
#9
Yuxia Cui, Junxian Song, Sufang Li, Chongyou Lee, Feng Zhang, Hong Chen
We aimed to investigate the distinctive miRNA profiles in the plasma of elderly patients with unstable angina (UA) and stable angina (SA), and to find more effective markers of UA in elderly people. We compared miRNA expression levels in plasma samples from 10 elderly patients with UA and 10 elderly patients with SA by using microarray-based miRNA chip, and then performed validation with Real-time PCR. Mir-1202, mir-1207-5p, and mir-1225-5p showed a statistically significant down-regulation (P < 0.05), while mir-3162-3p showed an up-regulation (P < 0...
January 15, 2018: International Heart Journal
https://www.readbyqxmd.com/read/29330663/human-cytomegalovirus-encoded-mir-ul112-contributes-to-hcmv-mediated-vascular-diseases-by-inducing-vascular-endothelial-cell-dysfunction
#10
Kai Shen, Liyun Xu, Dongdong Chen, Weiguo Tang, Yanyan Huang
Human cytomegalovirus (HCMV) infection has been linked to the pathogenesis of vasculopathy by inducing dysfunction of vascular cells such as endothelial cells. Hcmv-miR-UL112 is the most well-characterized HCMV-encoded microRNA occurring in the plasma of patients with cardiovascular diseases such as hypertension, while the specific underlying pathophysiological mechanisms are yet to be defined. The current study investigated the effect of hcmv-miR-UL112 on the growth and proliferation of human umbilical vascular endothelial cells (HUVECs); it might also be associated with signaling pathways...
January 12, 2018: Virus Genes
https://www.readbyqxmd.com/read/29329380/circulating-micrornas-as-potential-biomarkers-of-disease-activity-and-structural-damage-in-ankylosing-spondylitis-patients
#11
Carlos Perez-Sanchez, Pilar Font-Ugalde, Patricia Ruiz-Limon, Chary Lopez-Pedrera, Maria C Castro-Villegas, Maria C Abalos-Aguilera, Nuria Barbarroja, Ivan Arias-de la Rosa, Maria D Lopez-Montilla, Alejandro Escudero-Contreras, Clementina Lopez-Medina, Eduardo Collantes-Estevez, Yolanda Jimenez-Gomez
Ankylosing spondylitis (AS) remains difficult to diagnose before irreversible damage to sacroiliac joint is noticeable. Circulating microRNAs have demonstrated to serve as diagnostic tools for several human diseases. Here, we analyzed plasma microRNAs to identify potential AS biomarkers. Higher expression levels of microRNA (miR)-146a-5p, miR-125a-5p, miR-151-3p, and miR-22-3p, and lower of miR-150-5p, and miR-451a were found in AS versus healthy donors. Interestingly, higher miR-146a-5p, miR-125a-5p, miR-151-3p, miR-22-3p, and miR-451a expression was also observed in AS than psoriatic arthritis patients...
January 10, 2018: Human Molecular Genetics
https://www.readbyqxmd.com/read/29325455/influence-of-middle-distance-running-on-muscular-micro-rnas
#12
Elisa Danese, Marco Benati, Fabian Sanchis-Gomar, Cantor Tarperi, Gian Luca Salvagno, Elisa Paviati, Martina Montagnana, Federico Schena, Giuseppe Lippi
A specific subset of micro RNAs (miRs), including miR-133 and miR-206, is specifically expressed in muscle tissue, so that they are currently defined as muscular miRs (myomiRs). To further elucidate the role of myomiRs in muscle biology, we measured miR-133a and miR-206 in plasma of 28 middle-age recreational athletes. The study population consisted of 28 middle aged, recreation athletes (11 women and 17 men; mean age, 46 years) who completed a 21.1 km, half-marathon. The plasma concentration of miR-133a and miR-206, the serum concentration of creatine kinase (CK) and high-sensitivity (HS) cardiac troponin T (cTnT), as well as capillary lactate, were measured before and immediately after the run...
January 11, 2018: Scandinavian Journal of Clinical and Laboratory Investigation
https://www.readbyqxmd.com/read/29321815/circulating-plasma-microrna-profiling-in-patients-with-polymyositis-dermatomyositis-before-and-after-treatment-mirna-may-be-associated-with-polymyositis-dermatomyositis
#13
Takuya Hirai, Keigo Ikeda, Hiroshi Tsushima, Maki Fujishiro, Kunihiro Hayakawa, Yuko Yoshida, Shinji Morimoto, Ken Yamaji, Yoshinari Takasaki, Kenji Takamori, Naoto Tamura, Iwao Sekigawa
Background: MicroRNAs (miRNAs) are involved in the regulation of key biological processes and have been implicated in various diseases, including autoimmune disorders. The pathogenesis of polymyositis (PM) and dermatomyositis (DM) is considered to be mediated by autoimmune reactions. To determine miRNA role in the development and progression of PM and DM, we performed plasma miRNA profiling in PM/DM patients before and after treatment. Methods: Total RNA was isolated from plasma of 10 patients before and after treatment with prednisolone, or, in case of prednisolone resistance or complications, with the combination of calcineurin inhibitors (cyclosporine or tacrolims) and/or pulse intravenous cyclophosphamide...
2018: Inflammation and Regeneration
https://www.readbyqxmd.com/read/29314582/transcoronary-concentration-gradients-of-circulating-micrornas-in-heart-failure
#14
Salvatore De Rosa, Francesca Eposito, Cristina Carella, Antonio Strangio, Giuseppe Ammirati, Jolanda Sabatino, Fabio Giovanni Abbate, Claudio Iaconetti, Vincenzo Liguori, Valerio Pergola, Alberto Polimeni, Silvio Coletta, Clarice Gareri, Bruno Trimarco, Giuseppe Stabile, Antonio Curcio, Ciro Indolfi, Antonio Rapacciuolo
AIMS: Circulating levels of microRNAs (miRNAs) are emergent promising biomarkers for cardiovascular disease. Altered expression of miRNAs has been related to heart failure (HF) and cardiac remodelling. We measured the concentration gradients across the coronary circulation to assess their usefulness to diagnose HF of different aetiologies. METHODS AND RESULTS: Circulating miRNAs were measured in plasma samples simultaneously obtained from the aorta and the coronary venous sinus in patients with non-ischaemic HF (NICM-HF, n = 23) ischaemic HF (ICM-HF, n = 41), and in control patients (n = 11)...
January 4, 2018: European Journal of Heart Failure
https://www.readbyqxmd.com/read/29310530/unc569-induced-morphological-changes-in-pigment-epithelia-and-photoreceptor-cells-in-the-retina-through-mertk-inhibition-in-mice
#15
Ayako Sayama, Keiko Okado, Koichi Nakamura, Tatsuya Kawaguchi, Takuma Iguchi, Toshihiko Makino, Koichi Yabe, Kiyonori Kai, Kazuhiko Mori
Mer proto-oncogene tyrosine kinase (MerTK), which is expressed in the retinal pigment epithelium (RPE), regulates phagocytosis of shed photoreceptor outer segments (POS). To investigate the effects of drug-induced MerTK inhibition on the retina, UNC569, a specific MerTK inhibitor, was orally administered to male mice at a concentration of 60, 100, or 150 mg/kg for up to 14 days. Furthermore, MerTK inhibition in the retinal tissue sample was examined using a phosphorylation assay following a single dose of UNC569 at 100 mg/kg...
January 1, 2018: Toxicologic Pathology
https://www.readbyqxmd.com/read/29308623/mir-31-and-mir-145-as-potential-non-invasive-regulatory-biomarkers-in-patients-with-endometriosis
#16
Oranous Bashti, Mehrdad Noruzinia, Masoud Garshasbi, Morteza Abtahi
OBJECTIVES: Endometriosis is a prevalent gynecologic disease affecting 10% of women in reproductive age. Endometriosis is diagnosed by laparoscopy that was followed by histologic confirmation. Early diagnosis will lead to a more effective treatment with much less morbidity. As miR-31 and miR-145 are shown to be directly or indirectly correlated to biological processes involved in endometriosis, the aim of this study was to examine the association of miR-31 and miR-145 expression in plasma with the presence of endometriosis...
April 2018: Cell Journal
https://www.readbyqxmd.com/read/29306454/transcoronary-gradients-of-hdl-associated-micrornas-in-unstable-coronary-artery-disease
#17
Sébastien A Choteau, Luisa F Cuesta Torres, Jennifer Y Barraclough, Alexander M M Elder, Gonzalo J Martínez, William Y Chen Fan, Sudichhya Shrestha, Kwok L Ong, Philip J Barter, David S Celermajer, Kerry-Anne Rye, Sanjay Patel, Fatiha Tabet
AIMS: MicroRNAs (miRNAs) are transported on high-density lipoproteins (HDLs) and HDL-associated miRNAs are involved in intercellular communication. We explored HDL-associated miRNAs concentration gradients across the coronary circulation in stable and unstable coronary artery disease patients and whether changes in the transcoronary gradient were associated with changes in HDL composition and size. METHODS: Acute coronary syndrome (ACS, n=17) patients, those with stable coronary artery disease (stable CAD, n=19) and control subjects without CAD (n=6) were studied...
February 15, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29299981/normalizers-for-microrna-quantification-in-plasma-of-patients-with-vulvar-intraepithelial-neoplasia-lesions-and-vulvar-carcinoma
#18
Kamil Zalewski, Marcin Misiek, Artur Kowalik, Elwira Bakuła-Zalewska, Janusz Kopczyński, Aleksandra Zielińska, Mariusz Bidziński, Jakub Radziszewski, Stanisław Góźdź, Magdalena Kowalewska
The role of circulating microRNAs as a promising tool for diagnosing cancer and monitoring anticancer therapies has been widely studied in the past decades. To date, no suitable reference microRNAs for normalizing quantitative real-time polymerase chain reaction assays has been identified in vulvar intraepithelial neoplasia lesions and vulvar squamous cell carcinoma. The purpose of this study was to select appropriate references for gene expression studies in plasma of patients with these lesions. Expression levels of six microRNAs-hsa-miR-425-5p, hsa-miR-191-5p, hsa-miR-93-5p, hsa-miR-423-5p, hsa-miR-103a-3p, and hsa-miR-16-5p-were analyzed by quantitative reverse transcription polymerase chain reaction in plasma samples obtained from 17 patients with vulvar intraepithelial neoplasia lesion and 27 patients with vulvar squamous cell carcinoma...
November 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/29299796/analysis-of-circulating-extracellular-vesicle-associated-micrornas-in-cortisol-producing-adrenocortical-tumors
#19
Pál Perge, Ábel Decmann, Raffaele Pezzani, Irina Bancos, Ambrogio Fassina, Michaela Luconi, Letizia Canu, Miklós Tóth, Marco Boscaro, Attila Patócs, Peter Igaz
PURPOSE: Circulating microRNAs (miRNA) have been described in patients with adrenocortical tumors, but the expression of miRNAs in non-functioning and cortisol-producing tumors has not been yet compared. Therefore, the objective of this study was to evaluate the expression of plasma extracellular vesicle (EV)-associated microRNAs in patients with non-functioning adrenocortical adenoma (NFA), cortisol-producing adrenocortical adenoma (CPA) and cortisol-producing adrenocortical carcinoma (CP-ACC)...
January 3, 2018: Endocrine
https://www.readbyqxmd.com/read/29298817/circulating-mir-375-as-a-novel-prognostic-marker-for-metastatic-medullary-thyroid-cancer-patients
#20
Paola Romeo, Carla Colombo, Roberta Granata, Giuseppina Calareso, Ambra V Gualeni, Matteo Dugo, Loris De Cecco, Maria Grazia Rizzetti, Angela Zanframundo, Antonella Aiello, Maria Luisa Carcangiu, Annunziata Gloghini, Stefano Ferrero, Lisa Licitra, Angela Greco, Laura Fugazzola, Laura D Locati, Maria Grazia Borrello
This study aimed to identify circulating miRNAs as novel non-invasive biomarkers for prognosis and vandetanib response in advanced medullary thyroid cancer (MTC) patients. We prospectively recruited two independent cohorts of locally advanced/metastatic MTC patients including a subgroup of vandetanib-treated subjects: a discovery cohort (n = 20), including matched plasma/tissue samples (n = 17/20), and a validation cohort, yielding only plasma samples (n = 17). Plasma samples from healthy subjects (n = 36) and MTC patients in remission (n = 9) were used as controls...
January 3, 2018: Endocrine-related Cancer
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