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Plasma Mir

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https://www.readbyqxmd.com/read/28720782/dysregulated-mirnas-and-their-pathogenic-implications-for-the-neurometabolic-disease-propionic-acidemia
#1
Ana Rivera-Barahona, Alejandro Fulgencio-Covián, Celia Pérez-Cerdá, Ricardo Ramos, Michael A Barry, Magdalena Ugarte, Belén Pérez, Eva Richard, Lourdes R Desviat
miRNome expression profiling was performed in a mouse model of propionic acidemia (PA) and in patients' plasma samples to investigate the role of miRNAs in the pathophysiology of the disease and to identify novel biomarkers and therapeutic targets. PA is a potentially lethal neurometabolic disease with patients developing neurological deficits and cardiomyopathy in the long-term, among other complications. In the PA mouse liver we identified 14 significantly dysregulated miRNAs. Three selected miRNAs, miR-34a-5p, miR-338-3p and miR-350, were found upregulated in brain and heart tissues...
July 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28720759/depleted-tumor-suppressor-mir-107-in-plasma-relates-to-tumor-progression-and-is-a-novel-therapeutic-target-in-pancreatic-cancer
#2
Taisuke Imamura, Shuhei Komatsu, Daisuke Ichikawa, Mahito Miyamae, Wataru Okajima, Takuma Ohashi, Jun Kiuchi, Keiji Nishibeppu, Hirotaka Konishi, Atsushi Shiozaki, Ryo Morimura, Hisashi Ikoma, Toshiya Ochiai, Kazuma Okamoto, Hiroki Taniguchi, Eigo Otsuji
This study explored decreased tumor suppressor microRNA (miRNA) plasma levels in pancreatic cancer (PCa) patients to clarify their potential as novel biomarkers and therapeutic targets. We used the microRNA array-based approach to select candidates by comparing plasma levels between PCa patients and healthy volunteers. Six down-regulated miRNAs (miR-107, miR-126, miR-451, miR-145, miR-491-5p, and miR-146b-5p) were selected. Small- and large-scale analyses using samples from 100 PCa patients and 80 healthy volunteers revealed that miR-107 was the most down-regulated miRNA in PCa patients compared with healthy volunteers (P < 0...
July 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28710381/evaluation-and-diagnostic-potential-of-circulating-extracellular-vesicle-associated-micrornas-in-adrenocortical-tumors
#3
Pál Perge, Henriett Butz, Raffaele Pezzani, Irina Bancos, Zoltán Nagy, Krisztina Pálóczi, Gábor Nyírő, Ábel Decmann, Erna Pap, Michaela Luconi, Massimo Mannelli, Edit I Buzás, Miklós Tóth, Marco Boscaro, Attila Patócs, Peter Igaz
There is no available blood marker for the preoperative diagnosis of adrenocortical malignancy. The objective of this study was to investigate the expression of extracellular vesicle-associated microRNAs and their diagnostic potential in plasma samples of patients suffering from adrenocortical tumors. Extracellular vesicles were isolated either by using Total Exosome Isolation Kit or by differential centrifugation/ultracentrifugation. Preoperative plasma extracellular vesicle samples of 6 adrenocortical adenomas (ACA) and 6 histologically verified adrenocortical cancer (ACC) were first screened by Taqman Human Microarray A-cards...
July 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28710248/microrna-9-regulates-fetal-alcohol-induced-changes-in-d2-receptor-to-promote-prolactin-production
#4
Omkaram Gangisetty, Shaima Jabbar, Olivia Wynne, Dk K Sarkar
Fetal alcohol exposure (FAE) is known to increase prolactin (PRL) secretion from the pituitary lactotropes. In this study we determined whether microRNAs (miRs) are involved in FAE induced alteration in PRL release. We employed a rat animal model of FAE involving feeding pregnant Fisher 344 rats with a liquid diet containing 6.7% alcohol between gestational day 7 to 21 (AF). Both cyclic and estradiol implanted FAE females showed increased levels of plasma PRL and pituitary PRL mRNA but reduced levels of pituitary dopamine D2 receptor (D2R) and its short spliced form (D2S)...
July 14, 2017: Journal of Endocrinology
https://www.readbyqxmd.com/read/28699915/circulating-mirnas-as-novel-diagnostic-biomarkers-in-hepatocellular-carcinoma-detection-a-meta-analysis-based-on-24-articles
#5
Yan Ding, Jia-Iai Yan, An-Ning Fang, Wei-Feng Zhou, Ling Huang
The diagnostic value and suitability of circulating miRNAs for the detection of hepatocellular carcinoma have been inconsistent in the literature. A meta-analysis to systematically evaluate the diagnostic value of circulating miRNAs. Eligible studies were selected and the heterogeneity was assessed by subgroup analysis, meta-regression, and publication bias. After strictly and comprehensive screening, the source methods, internal reference and the cut-off values of the included miRNAs were first listed. Circulating miRNAs demonstrated a relatively good diagnostic value in hepatocellular carcinoma, In the subgroup analysis, diagnosis odds ratio showed a higher accuracy with multiple miRNAs than with a single miRNA as well as with serum types than plasma types...
July 4, 2017: Oncotarget
https://www.readbyqxmd.com/read/28699362/elevated-levels-of-granzyme-b-correlated-with-mir-874-3p-downregulation-in-patients-with-acute-myocardial-infarction
#6
Youyou Yan, Xinjing Song, Zhibo Li, Jinpu Zhang, Jiajun Ren, Junduo Wu, Yali Li, Yinuo Guan, Junnan Wang
AIM: Granzyme B could induce apoptosis of target cell in acute myocardial infarction (AMI) and was identified as the target of miR-874-3p by searching the miRNA database. We aim to determine the levels of granzyme B and miR-874-3p as well as assay their correlations or predict powers in AMI. PATIENTS & METHODS: We measured levels of plasma granzyme B and miR-874-3p in 80 AMI patients or 40 healthy controls and assayed their correlations or predicted powers for AMI...
July 12, 2017: Biomarkers in Medicine
https://www.readbyqxmd.com/read/28694557/overexpression-of-mir-24-is-involved-in-the-formation-of-hypocoagulation-state-after-severe-trauma-by-inhibiting-the-synthesis-of-coagulation-factor-x
#7
Lu-Jia Chen, Lian Yang, Xing Cheng, Yin-Kai Xue, Li-Bo Chen
BACKGROUND: Dysregulation of microRNAs may contribute to the progression of trauma-induced coagulopathy (TIC). We aimed to explore the biological function that miRNA-24-3p (miR-24) might have in coagulation factor deficiency after major trauma and TIC. METHODS: 15 healthy volunteers and 36 severe trauma patients (Injury Severity Score ≥ 16 were enrolled. TIC was determined as the initial international normalized ratio >1.5. The miR-24 expression and concentrations of factor X (FX) and factor XII in plasma were measured...
2017: Disease Markers
https://www.readbyqxmd.com/read/28694210/circulating-microrna-expression-as-predictor-of-preeclampsia-and-its-severity
#8
Deeba S Jairajpuri, Zainab H Malalla, Naeema Mahmood, Wassim Y Almawi
Preeclampsia (PE) is a pregnancy syndrome characterized by hypertension and proteinuria, and a leading cause of maternal and fetal morbidity and mortality, with poorly defined pathophysiological mechanisms remain. Circulating microRNAs (miRNAs) are small, noncoding RNA molecules, which negatively regulate gene expression, and considered as promising biomarkers for PE. The objective of the study was to evaluate circulating miRNA signatures in women with PE compared to healthy women, and in women sub-grouped per PE severity...
July 7, 2017: Gene
https://www.readbyqxmd.com/read/28693239/biological-effects-and-clinical-characteristics-of-microrna-106a-in-human-colorectal-cancer
#9
Yuzheng He, Guiqi Wang, Lei Zhang, Congjie Zhai, Jun Zhang, Xusheng Zhao, Xia Jiang, Zengren Zhao
MicroRNAs serve important roles in various diseases, particularly cancer. microRNA-106a (miR-106a) exhibits abnormal expression and oncogenic activity in carcinogenesis. The clinical significance of the abnormal expression of miR-106a in colorectal cancer is poorly understood. In the present study, miR-106a expression from colorectal cancer tissues was quantified using the reverse transcription-quantitative polymerase chain reaction. The overexpression or knockdown of miR-106a was performed by transfection with microRNA mimic or inhibitor in human colorectal carcinoma HCT116 cells...
July 2017: Oncology Letters
https://www.readbyqxmd.com/read/28692540/unique-microrna-expression-in-the-colonic-mucosa-during-chronic-hiv-1-infection
#10
Jennifer A Fulcher, Georgios Koukos, Marina Koutsioumpa, Julie Elliott, Alexandra Drakaki, Dimitrios Iliopoulos, Peter A Anton
OBJECTIVE: Chronic HIV-1 infection leads to widespread inflammation and immune dysregulation. The gastrointestinal mucosa, a primary site for HIV-1 replication, is thought to play a significant role in this response. MicroRNAs (miRs) are small non-coding RNAs that regulate gene expression, including immune activation and inflammation. Here we investigate miR expression and function in the colonic mucosa during HIV-1 infection. DESIGN AND METHODS: Using miR profiling, we examined miR expression in the colonic mucosa of HIV-infected subjects...
July 7, 2017: AIDS
https://www.readbyqxmd.com/read/28690868/mirna-200c-3p-is-crucial-in-acute-respiratory-distress-syndrome
#11
Qiang Liu, Jianchao Du, Xuezhong Yu, Jun Xu, Fengming Huang, Xiaoyun Li, Cong Zhang, Xiao Li, Jiahui Chang, Daozhen Shang, Yan Zhao, Mingyao Tian, Huijun Lu, Jiantao Xu, Chang Li, Huadong Zhu, Ningyi Jin, Chengyu Jiang
Influenza infection and pneumonia are known to cause much of their mortality by inducing acute respiratory distress syndrome (ARDS), which is the most severe form of acute lung injury (ALI). Angiotensin-converting enzyme 2 (ACE2), which is a negative regulator of angiotensin II in the renin-angiotensin system, has been reported to have a crucial role in ALI. Downregulation of ACE2 is always associated with the ALI or ARDS induced by avian influenza virus, severe acute respiratory syndrome-coronavirus, respiratory syncytial virus and sepsis...
2017: Cell Discovery
https://www.readbyqxmd.com/read/28690499/reduced-circulating-levels-of-mir-433-and-mir-133b-are-potential-biomarkers-for-parkinson-s-disease
#12
Xiong Zhang, Rui Yang, Bei-Lei Hu, Pengcheng Lu, Li-Li Zhou, Zhi-Yong He, Hong-Mei Wu, Jian-Hong Zhu
Aberrant expression of microRNA (miRNA) in tissues may lead to altered level in circulation. Considerable evidence has suggested that miRNA deregulation is involved in the pathogenesis of Parkinson's disease (PD). In this study, we screened a set of PD-associated miRNAs and aimed to identify differentially expressed miRNAs in plasma of PD patients and to evaluate their potentiality to serve as PD biomarkers. A total of 95 subjects consisting of 46 sporadic PD cases and 49 controls were recruited. Plasma levels of six miRNAs including miR-433, miR-133b, miR-34b, miR-34c, miR-153, and miR-7 were evaluated using reverse transcribed quantitative PCR, among which we found that miR-34c and miR-7 were below detection limit under our condition...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/28685964/hsa_circ_0013958-a-circular-rna-and-potential-novel-biomarker-for-lung-adenocarcinoma
#13
Xiaoli Zhu, Xiyong Wang, Shuzhen Wei, Yan Chen, Yang Chen, Xiaobo Fan, Shuhua Han, Guoqiu Wu
Circular RNAs (circRNAs) are associated with cancer progression and metastasis, although little is known about their role in lung adenocarcinoma (LAC). In the present study, microarrays were first used to screen for tumour-specific circRNA candidates in LAC tissue. Thirty-nine circRNAs were found to be up-regulated and 20 were down-regulated (fold change > 2.0). Among them, hsa_circ_0013958 was further confirmed to be up-regulated in all of the LAC tissues, cells and plasma. In addition, hsa_circ_0013958 levels were associated with TNM stage (P = 0...
July 7, 2017: FEBS Journal
https://www.readbyqxmd.com/read/28684747/mir-320a-as-a-potential-novel-circulating-biomarker-of-arrhythmogenic-cardiomyopathy
#14
Elena Sommariva, Yuri D'Alessandra, Floriana Maria Farina, Michela Casella, Fabio Cattaneo, Valentina Catto, Mattia Chiesa, Ilaria Stadiotti, Silvia Brambilla, Antonio Dello Russo, Corrado Carbucicchio, Giulia Vettor, Daniela Riggio, Maria Teresa Sandri, Andrea Barbuti, Gianluca Vernillo, Manuela Muratori, Matteo Dal Ferro, Gianfranco Sinagra, Silvia Moimas, Mauro Giacca, Gualtiero Ivanoe Colombo, Giulio Pompilio, Claudio Tondo
Diagnosis of Arrhythmogenic CardioMyopathy (ACM) is challenging and often late after disease onset. No circulating biomarkers are available to date. Given their involvement in several cardiovascular diseases, plasma microRNAs warranted investigation as potential non-invasive diagnostic tools in ACM. We sought to identify circulating microRNAs differentially expressed in ACM with respect to Healthy Controls (HC) and Idiopathic Ventricular Tachycardia patients (IVT), often in differential diagnosis. ACM and HC subjects were screened for plasmatic expression of 377 microRNAs and validation was performed in 36 ACM, 53 HC, 21 IVT...
July 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28684219/elevated-plasma-levels-of-mir-29a-are-associated-with-hemolysis-in-patients-with-hypertrophic-cardiomyopathy
#15
Dimitrios Ntelios, Soultana Meditskou, Georgios Efthimiadis, Antonios Pitsis, Eleni Nikolakaki, Fotios Girtovitis, Despoina Parcharidou, Thomas Zegkos, Sofia Kouidou, Haralampos Karvounis, Georgios Tzimagiorgis
BACKGROUND: miR-29a is a small non-coding RNA that is known to repress collagen synthesis. Interestingly, elevated plasma miR-29a was reported to correlate with pronounced myocardial fibrosis in patients with hypertrophic cardiomyopathy. The objective of this study was to elucidate the origin of plasma miR-29a, and evaluate its significance as a biomarker. METHODS: miR-29a expression was evaluated in plasma (n=50) and myocardial samples (n=4) from patients with hypertrophic cardiomyopathy using RT-qPCR...
July 4, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28678312/identification-of-mirnas-as-atherosclerosis-biomarkers-and-functional-role-of-mir-126-in-atherosclerosis-progression-through-mapk-signalling-pathway
#16
X-Z Hao, H-M Fan
OBJECTIVE: Mounting evidence suggests the role of microRNAs (miRNAs) in regulating inflammatory responses in various vascular diseases. Inflammation is the key mechanism leading to atherosclerosis (AS) and various miRNAs are aberrantly expressed in response to AS pathophysiology. However, there are very limited studies that serve to elucidate the role of specific miRNA in in vivo or in vitro AS models. MATERIALS AND METHODS: Microarray analysis of blood plasma of apolipoprotein deficient (apoE-/-) mice was performed followed by the confirmation using qPCR...
June 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28677735/mir%C3%A2-199a%C3%A2-3p-is-involved-in-the-pathogenesis-and-progression-of-diabetic-neuropathy-through-downregulation-of-serpine2
#17
Ying-Bo Li, Qun Wu, Jie Liu, Yong-Zhi Fan, Kai-Feng Yu, Yi Cai
The present study aimed to investigate the expression status of miRNA‑199a‑3p in patients with diabetic neuropathy (DN) and the mechanism by which this miRNA is involved in the genesis of DN. The expression of miRNA‑199a‑3p in plasma of peripheral blood was compared between patients with diabetes and a family history of diabetes and control volunteers by reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR); in 60 diabetes patients, 45 (75%) demosntrated upregulated miR‑199a‑3p expression compared with control volunteer plasma...
June 28, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28677323/caloric-restriction-impacts-plasma-micrornas-in-rhesus-monkeys
#18
Augusto Schneider, Joseph M Dhahbi, Hani Atamna, Josef P Clark, Ricki J Colman, Rozalyn M Anderson
Caloric restriction (CR) is one of the most robust interventions shown to delay aging in diverse species, including rhesus monkeys (Macaca mulatta). Identification of factors involved in CR brings a promise of translatability to human health and aging. Here, we show that CR induced a profound change in abundance of circulating microRNAs (miRNAs) linked to growth and insulin signaling pathway, suggesting that miRNAs are involved in CR's mechanisms of action in primates. Deep sequencing of plasma RNA extracts enriched for short species revealed a total of 243 unique species of miRNAs including 47 novel species...
July 5, 2017: Aging Cell
https://www.readbyqxmd.com/read/28675303/plasma-mir-200b-3p-level-for-oral-squamous-cell-carcinoma-diagnosis
#19
Guo-Ming Zhang
No abstract text is available yet for this article.
July 4, 2017: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/28670374/combination-of-circulating-mir-19b-3p-mir-122-5p-and-mir-486-5p-expressions-correlates-with-risk-and-disease-severity-of-knee-osteoarthritis
#20
Ruina Kong, Jie Gao, Yanhui Si, Dongbao Zhao
The aim of this study was to investigate the association of circulating miRNAs profile with the risk of knee osteoarthritis (OA), and evaluate their correlation with clinical characteristics. This study was divided into two parts: exploration stage and validation stage. In exploration stage, 8 knee OA patients and 8 age and gender highly matched health controls (HCs) were recruited, and plasma sample were collected for microarray examination. Differentially expressed miRNAs and enrichment analysis were subsequently performed...
2017: American Journal of Translational Research
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