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https://www.readbyqxmd.com/read/29458210/preparation-of-a-solid-self-microemulsifying-drug-delivery-system-by-hot-melt-extrusion
#1
Luis Antonio D Silva, Susana L Almeida, Ellen C P Alonso, Priscila B R Rocha, Felipe T Martins, Luís A P Freitas, Stephania F Taveira, Marcilio S S Cunha-Filho, Ricardo N Marreto
Hot-melt extrusion (HME) has gained increasing attention in the pharmaceutical industry; however, its potential in the preparation of solid self-emulsifying drug delivery systems (S-SMEDDS) is still unexplored. This study sought to prepare enteric S-SMEDDS by HME and evaluate the effects of the process and formulation variables on S-SMEDDS properties via Box-Behnken design. Liquid SMEDDS were developed, and carvedilol was used as a class II model drug. Mean size, polydispersity index (PdI) and zeta potential of the resulting microemulsions were determined...
February 16, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29458206/mucoadhesive-self-emulsifying-delivery-systems-for-ocular-administration-of-econazole
#2
Ibrahim A Elbahwy, Noemi Lupo, Hany M Ibrahim, Hatem R Ismael, Alaa A Kasem, Cagri Caliskan, Barbara Matuszczak, Andreas Bernkop-Schnürch
AIM: Development of mucoadhesive self-emulsifying drug delivery systems (SEDDS) providing a prolonged ocular residence time for poorly soluble active pharmaceutical ingredient. METHODS: L-Cysteine was covalently linked to 6-mercaptonicotinamide. The obtained ligand, Cysteine-6- mercaptonicotinamide (Cys-6-MNA) was attached to Eudragit® L100-55 via a carbodiimide mediated amide bond formation. The resulting entirely S-protected thiolated Eudragit® L100-55 was characterized regarding the degree of modification as well as stability toward oxidation in the presence of strong oxidizing agent (H2 O2 )...
February 16, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29457726/a-robust-oil-in-oil-emulsion-for-the-nonaqueous-encapsulation-of-hydrophilic-payloads
#3
Xiaocun Lu, Joshua S Katz, Adam Schmitt, Jeffrey S Moore
Compartmentalized structures widely exist in cellular systems (organelles) and perform essential functions in smart composite materials (microcapsules, vasculatures, and micelles) to provide localized functionality and enhance materials compatibility. An entirely water-free compartmentalization system is of significant value to the materials community as nonaqueous conditions are critical to packaging microcapsules with water-free hydrophilic payloads while avoiding energy-intensive drying steps. Few nonaqueous encapsulation techniques are known, especially when considering just the scalable processes that operate in batch mode...
February 19, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29455997/effect-of-dynamic-high-pressure-on-emulsifying-and-encapsulant-properties-of-cashew-tree-gum
#4
Bruna Castro Porto, Marcelo Cristianini
Dynamic high pressure (DHP) has been applied in the physical modification of biopolymers as polysaccharides, proteins and gums. It is known that DHP is able to promote degradation of polysaccharides (e.g. molecular weight reduction). However, few studies have assessed the effect of DHP on the emulsifying and encapsulating properties of polysaccharides. Thus, this study aimed to investigate the effect of DHP on the emulsifying (average droplet size and particle size distribution, optical and confocal scanning laser microscopy, rheology, zeta potential and electric conductivity, creaming index, and turbidity) and encapsulating (scanning electronic microscopy, flavor retention, average droplet size, and particle size distribution) properties of cashew tree gum (CG)...
April 15, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29453437/enhancement-of-immunomodulative-effect-of-lactic-acid-bacteria-on-plasmacytoid-dendritic-cells-with-sucrose-palmitate
#5
Masaya Kanayama, Yukiko Kato, Toshikazu Tsuji, Yuki Konoeda, Akiko Hashimoto, Osamu Kanauchi, Toshio Fujii, Daisuke Fujiwara
Plasmacytoid dendritic cells (pDCs) play a key role in the immune response against viruses. In addition, recent research has suggested that pDCs possess direct and indirect tumoricidal activities. We previously found that a lactic acid bacteria strain, Lactococcus lactis JCM 5805 (LC-Plasma), stimulated pDCs and prevented viral infection in mouse and human studies. Meanwhile, emulsifiers have recently been highlighted as candidate adjuvants for some viral vaccines and cancer immunotherapies. In this study, we discovered some specific emulsifiers, mainly consisting of sucrose fatty acid esters, that drastically enhance the potency of LC-Plasma to activate pDCs in vitro...
February 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29452970/effect-of-tear-supplements-on-signs-symptoms-and-inflammatory-markers-in-dry-eye
#6
Eilidh Martin, Katherine M Oliver, E Ian Pearce, Alan Tomlinson, Peter Simmons, Suzanne Hagan
PURPOSE: Three tear supplements were compared for their effects on the signs, symptoms and inflammatory status of subjects with dry eye disease. Assessments were made before and after both 2 and 4 weeks of treatment. METHODS: In this masked, randomized, 3-way crossover trial, eighteen dry eye subjects were recruited. At each visit, symptoms, tear evaporation rate, stability and osmolarity were measured and tear samples were analyzed for 7 inflammatory markers, using multiplex immunoassays...
February 13, 2018: Cytokine
https://www.readbyqxmd.com/read/29452848/optimization-of-liquid-fermentation-conditions-for-biotransformation-zein-by-cordyceps-militaris-202-and-characterization-of-physicochemical-and-functional-properties-of-fermentative-hydrolysates
#7
Shuang Yang, Mingzhu Zheng, Yong Cao, Yanjiao Dong, Sanabil, Jingsheng Liu
Cordyceps militaris 202 is a potential fungus for biotransformation zein, due to its various proteases, high tolerance and viability in nature. In this article, single factor experiment and response surface methodology were applied to optimize the liquid fermentation conditions and improve the ability of biotransformation zein. The optimized fermentation conditions were as follows: inoculum concentration of 19%, volume of liquor of 130mL/500mL and pH of 4.7. Under this condition, the degree of hydrolysis (DH) was 27...
February 13, 2018: Brazilian Journal of Microbiology: [publication of the Brazilian Society for Microbiology]
https://www.readbyqxmd.com/read/29448899/dietary-exposure-of-the-belgian-population-to-emulsifiers-e481-sodium-stearoyl-2-lactylate-and-e482-calcium-stearoyl-2-lactylate
#8
Sarah Bel, Thomas Struyf, Tine Fierens, Griet Jacobs, Christine Vinkx, Mia Bellemans, Stefan Voorspoels, Karin De Ridder
A dietary exposure assessment of food emulsifiers E481 (sodium stearoyl-2-lactylate) and E482 (calcium stearoyl-2-lactylate) in the Belgian population was performed. Nationally representative food consumption data from the Belgian National Food Consumption Surveys 2004 (BNFCS2004) and 2014 (BNFCS2014) were used for calculations. A conservative approach (combining individual food consumption data with the maximum permitted level (MPL) of foods (tier 2), was compared with more refined estimates (combining individual food consumption data with actual concentrations measured in food products available on the Belgian market (tier 3))...
February 15, 2018: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://www.readbyqxmd.com/read/29441979/using-pva-and-tpgs-as-combined-emulsifier-in-nanoprecipitation-method-improves-characteristics-and-anticancer-activity-of-ibuprofen-loaded-plga-nanoparticles
#9
A Sahin, F Spiroux, I Guedon, F B Arslan, E T Sarcan, T Ozkan, N Colak, S Yuksel, S Ozdemir, B Ozdemir, S Akbas, G Ultav, Y Aktas, Y Capan
In the preparation of nanoparticles (NPs) by the nanoprecipitation method, emulsifiers play a key role for NPs' characteristics. The present study aimed to investigate the combined emulsifier effect on ibuprofen loaded poly(lactic-co-glycolic acid) (PLGA) NPs' characteristics and anticancer activity. Ibuprofen loaded PLGA NPs were prepared by nanoprecipitation using different concentrations of PVA (poly(vinyl alcohol)) or PVA-TPGS (d-α-tocopherol polyethylene glycol 1000 succinate) combination as emulsifier...
September 1, 2017: Die Pharmazie
https://www.readbyqxmd.com/read/29439533/molecular-and-functional-properties-of-protein-fractions-and-isolate-from-cashew-nut-anacardium-occidentale-l
#10
Cheng-Mei Liu, Qian Peng, Jun-Zhen Zhong, Wei Liu, Ye-Jun Zhong, Fang Wang
Some molecular and functional properties of albumin (83.6% protein), globulin (95.5% protein), glutelin (81.3% protein) as well as protein isolate (80.7% protein) from cashew nut were investigated. These proteins were subjected to molecular (circular dichroism, gel electrophoresis, scanning electron microscopy) and functional (solubility, emulsification, foaming, water/oil holding capacity) tests. Cashew nut proteins represent an abundant nutrient with well-balanced amino acid composition and could meet the requirements recommended by FAO/WHO...
February 12, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29437527/first-victim-later-aggressor-how-the-intestinal-microbiota-drives-the-pro-inflammatory-effects-of-dietary-emulsifiers
#11
Emilie Viennois, Benoit Chassaing
The intestinal tract is inhabited by a large and diverse community of bacteria, collectively referred to as the gut microbiota. Composed of 500-1000 distinct species, the intestinal microbiota plays an important role in immunity and metabolism. However, alterations in its composition are associated with a variety of inflammatory diseases including obesity, diabetes, and inflammatory bowel disease (IBD). Among many other factors, our diet impacts microbiota composition and function, in either beneficial or detrimental ways...
February 13, 2018: Gut Microbes
https://www.readbyqxmd.com/read/29434396/structural-and-functional-properties-of-exopolysaccharide-excreted-by-a-novel-bacillus-anthracis-strain-pfab2-of-hot-spring-origin
#12
Aparna Banerjee, Shalini Gaur Rudra, Koushik Mazumder, Vinod Nigam, Rajib Bandopadhyay
Exopolysaccharide produced by a unique avirulent Bacillus anthracis strain PFAB2 of hot spring origin has been characterized and its functional properties are investigated which is a first report. Maximum yield of EPS is 7.66 g/l with 2% glucose and 1% peptone as optimum carbon and nitrogen source respectively. The EPS is found to be a homopolymer consisting of only glucose as principle monosaccharide component. Through 1H NMR study, different dextran-like proton peaks are observed. Molecular weight of the EPS resembles low molecular weight bacterial origin polysaccharides...
March 2018: Indian Journal of Microbiology
https://www.readbyqxmd.com/read/29433910/effect-of-the-coexistence-of-sodium-caseinate-and-tween-20-as-stabilizers-of-food-emulsions-at-acidic-ph
#13
Luisa Perugini, Giuseppe Cinelli, Martina Cofelice, Andrea Ceglie, Francesco Lopez, Francesca Cuomo
In the present investigation the properties of edible nanoemulsions were studied. Sodium caseinate represents a good candidate for food emulsion preparations thanks to its surface-active properties and because it is perceived as a natural product by consumers. Nevertheless, it is very sensitive to acidic pH close to its isoelectric point and, if used as emulsion stabilizer, this aspect can negatively affect the emulsion stability. In order to prevent this drawback, sodium caseinate was used in combination with a non-ionic surfactant (Tween 20) as emulsifier of oil/water nanoemulsions...
February 5, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29433276/interfacial-activity-and-emulsifying-behaviour-of-inclusion-complexes-between-helical-polysaccharides-and-flavouring-molecules-resulting-from-non-covalent-interactions
#14
Louise De Fenoyl, Déborah Hirel, Emile Perez, Sophie Lecomte, Estelle Morvan, Mathieu Delample
This study deals with the fabrication of inclusion complexes starting from a cross coupling of seven helical polysaccharides (host) and six flavouring agents (guest). Neither of the substrates is considered as an emulsifier when studied alone. Due to a complexation mechanism, the presence of intermolecular hydrogen bonds between substrates was highlighted by infra-red spectroscopy and 13 C NMR. In addition, depending on the polysaccharide used, the guest molecule could be preferentially located either inside or in the interstitial spaces of the helix...
March 2018: Food Research International
https://www.readbyqxmd.com/read/29433230/in-vitro-digestion-behavior-of-water-in-oil-in-water-emulsions-with-gelled-oil-water-inner-phases
#15
Jonathan Andrade, Amanda J Wright, Milena Corredig
Double emulsions may be able to protect and release in a controlled manner bioactive compounds during digestion of food matrices. It was hypothesized that the physical state and solid content in the inner phases of water-in-oil-in-water (W1/O/W2) emulsions may affect the overall stability and the release behavior of bioactives during in vitro digestion. Therefore, hydrophobic (phytosterols or Vitamin D3) and hydrophilic (Vitamin B12) molecules were incorporated in double emulsions prepared either with a liquid (soybean oil - SO) or oil-fat gel (soybean oil+trimyristin - STO) lipid phase and liquid internal aqueous phase...
March 2018: Food Research International
https://www.readbyqxmd.com/read/29429693/swirling-cavitation-improves-the-emulsifying-properties-of-commercial-soy-protein-isolate
#16
Feng Yang, Xue Liu, Xian'e Ren, Yongchun Huang, Chengdu Huang, Kunming Zhang
Since emulsifying properties are important functional properties of soy protein, many physical, chemical, and enzymatic methods have been applied to treat soy protein to improve emulsifying properties. In this study, we investigated the effects of swirling cavitation at different pressures and for different times on emulsifying and physicochemical properties of soy protein isolate (SPI). The SPI treated with swirling cavitation showed a significant decrease in particle size and increase in solubility. Emulsions formed from treated SPI had higher emulsifying activity and emulsifying stability indexes, smaller oil droplet sizes, lower flocculation indexes, higher adsorbed proteins, lower interfacial protein concentrations, and lower creaming indexes than those formed from untreated SPI, indicating that swirling cavitation improved the emulsifying properties of the SPI...
April 2018: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/29429667/effects-of-ultrasonic-and-graft-treatments-on-grafting-degree-structure-functionality-and-digestibility-of-rapeseed-protein-isolate-dextran-conjugates
#17
Wenjuan Qu, Xinxin Zhang, Weiyu Chen, Zhiping Wang, Ronghai He, Haile Ma
Rapeseed protein isolate (RPI) and dextran conjugates were prepared by traditional and ultrasonic assisted wet-heating. The effects on the grafting degree (GD), structure, functionality, and digestibility of conjugates were studied. Ultrasonic frequency, temperature, and time all significantly affected the GD. Under the optimum conditions (temperature of 90 °C and time of 60 min), compared to traditional wet-heating, ultrasonic treatment at 28 kHz significantly increased the GD by 2.12 times. Compared to RPI, surface hydrophobicities of conjugates were significantly decreased by graft and ultrasonic treatments...
April 2018: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/29428793/confocal-raman-microspectroscopy-as-an-alternative-method-to-investigate-the-extraction-of-lipids-from-stratum-corneum-by-emulsifiers-and-formulations
#18
Ziwei Zhang, Dominique Jasmin Lunter
The purpose of this study was to investigate the impact of emulsifiers and formulations on intercellular lipids of porcine stratum corneum (SC) and evaluate confocal Raman microscopy (CRM) as an alternative method in this research context. To this end, four different formulations were used: three conventional creams that contained ionic and/or non-ionic emulsifiers and one surfactants-free emulsion stabilized by a polymeric emulsifier. Additionally, all emulsifiers were tested in aqueous solution/dispersion in the respective concentrations as present in the formulations...
February 8, 2018: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/29422862/geraniol-pharmacokinetics-bioavailability-and-its-multiple-effects-on-the-liver-antioxidant-and-xenobiotic-metabolizing-enzymes
#19
Barbara Pavan, Alessandro Dalpiaz, Luca Marani, Sarah Beggiato, Luca Ferraro, Donatella Canistro, Moreno Paolini, Fabio Vivarelli, Maria C Valerii, Antonietta Comparone, Luigia De Fazio, Enzo Spisni
Geraniol is a natural monoterpene showing anti-inflammatory, antioxidant, neuroprotective and anticancer effects. No pharmacokinetic and bioavailability data on geraniol are currently available. We therefore performed a systematic study to identify the permeation properties of geraniol across intestinal cells, and its pharmacokinetics and bioavailability after intravenous and oral administration to rats. In addition, we systematically investigated the potential hepatotoxic effects of high doses of geraniol on hepatic phase I, phase II and antioxidant enzymatic activities and undertook a hematochemical analysis on mice...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29421676/dynamic-forces-between-emulsified-water-drops-coated-with-poly-glycerol-poly-ricinoleate-pgpr-in-canola-oil
#20
Srinivas Mettu, Chu Wu, Raymond R Dagastine
The dynamic collision of emulsified water drops in the presence of non-ionic surfactants plays a crucial role in many practical applications. Interaction force between water drops coated with non-ionic food grade surfactants is expected to exhibit rich dynamic behavior that is not yet explored. The collision forces between immobilized water drops in canola oil in the presence of a well-known food grade surfactant polyglycerol polyricinoleate (PGPR) are measured at concentrations well below typically used to form stable emulsions...
January 31, 2018: Journal of Colloid and Interface Science
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