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https://www.readbyqxmd.com/read/28545546/emulsifying-dietary-fat-modulates-postprandial-endotoxemia-associated-with-chylomicronemia-in-obese-men-a-pilot-randomized-crossover-study
#1
Cécile Vors, Jocelyne Drai, Gaëlle Pineau, Martine Laville, Hubert Vidal, Fabienne Laugerette, Marie-Caroline Michalski
BACKGROUND: Postprandial hyperlipemia is recognized as a major cardio-metabolic risk factor, recently linked to the co-absorption of pro-inflammatory lipopolysaccharides with dietary lipids. This causes endotoxemia that is involved in the pathophysiology of obesity and insulin resistance, but to date the impact of food formulation is unknown. We tested a novel concept that endotoxin absorption can be modulated by fat emulsified structure in the meal, and potentially differently in obese vs...
May 25, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28541052/janus-particles-templated-by-janus-emulsions-and-application-as-pickering-emulsifier
#2
Duo Wei, Lingling Ge, Shuhui Lu, Jingjing Li, Rong Guo
One-step vibrational mixing has afforded batch-scale preparation of Janus emulsion. Fabrication of Janus particles (JPs) templated by the Janus emulsions was motivated as the topology and composition of the Janus droplets were highly tunable and controllable. Two immiscible polymerizable monomers were introduced as inner phases of Janus emulsion. The advanced geometry of the resultant JPs was easily and precisely controlled from "snowman" to "dumbbell" by adjusting the mass ratio of two oils in initial emulsion...
May 25, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28541029/homochiral-mof-as-circular-dichroism-sensor-for-enantioselective-recognition-on-nature-and-chirality-of-unmodified-amino-acids
#3
Yan-Wu Zhao, Yan Wang, Xian-Ming Zhang
Self-assembly of zinc salt with rationally designed chiral ligand, (1R,2R)-2-(pyridine-4-yl carbamoyl) cyclohexanecarboxylic acid (RR-PCCH) generated 2D homochiral metal-organic framework [Zn(RR-PCCHC)2] (HMOF-1) that is composed of DNA-like right-handed double-helix structure. HMOF-1 shows high solvent and thermal stability and is also stable in neutral, weak acidic and weak basic aqueous solution. Emulsified HMOF-1 shows strong inherent circular dichroism (CD) signal in aqueous solution, which can show regular intensity change by induction of amino acids...
May 25, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28539182/the-lack-of-ivivc-for-monoacyl-phospholipid-based-self-emulsifying-drug-delivery-systems
#4
EDITORIAL
Kinam Park
No abstract text is available yet for this article.
June 10, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28534835/emulsion-based-intradermal-delivery-of-melittin-in-rats
#5
Sang Mi Han, Se Gun Kim, Sok Cheon Pak
Bee venom (BV) has long been used as a traditional medicine. The aim of the present study was to formulate a BV emulsion with good rheological properties for dermal application and investigate the effect of formulation on the permeation of melittin through dermatomed rat skin. A formulated emulsion containing 1% (w/v) BV was prepared. The emulsion was compared with distilled water (DW) and 25% (w/v) N-methyl-2-pyrrolidone (NMP) in DW. Permeation of melittin from aqueous solution through the dermatomed murine skin was evaluated using the Franz diffusion cells...
May 19, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28534401/physical-and-oxidative-stability-of-flaxseed-oil-in-water-emulsions-fabricated-from-sunflower-lecithins-impact-of-blending-lecithins-with-different-phospholipid-profiles
#6
Li Liang, Fang Chen, Xing-Guo Wang, Qingzhe Jin, Eric A Decker, David Julian McClements
There is great interest in the formulation of plant-based foods enriched with nutrients that promote health, such as polyunsaturated fatty acids. This study evaluated the impact of sunflower phospholipid type on the formation and stability of flaxseed oil-in-water emulsions. Two sunflower lecithins (Sunlipon 50 and 90) with different phosphatidylcholine (PC) levels (59 and 90%, respectively) were used in varying ratios to form emulsions. Emulsion droplet size, charge, appearance, microstructure, and oxidation were measured during storage at 55 C in the dark...
May 23, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28532667/evaluation-of-three-recombinant-outer-membrane-proteins-ompa1-tdr-and-tbpa-as-potential-vaccine-antigens-against-virulent-aeromonas-hydrophila-infection-in-channel-catfish-ictalurus-punctatus
#7
Hossam Abdelhamed, Iman Ibrahim, Seong Won Nho, Michelle M Banes, Robert W Wills, Attila Karsi, Mark L Lawrence
A virulent clonal population of Aeromonas hydrophila (VAh) is recognized as the etiological agent in outbreaks of motile aeromonas septicemia (MAS) in catfish aquaculture in the southeastern United States since 2009. Genomic subtraction revealed three outer membrane proteins present in VAh strain ML09-119 but not in low virulence reference A. hydrophila strains: major outer membrane protein OmpA1, TonB-dependent receptor (Tdr), and transferrin-binding protein A (TbpA). Here, the genes encoding ompA1, tdr, and tbpA were cloned from A...
May 19, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28532080/antibiotic-loaded-microspheres-as-antimicrobial-delivery-systems-for-medical-applications
#8
J Szczeblinska, K Fijalkowski, J Kohn, M El Fray
In this paper, we present the preparation and antibiotic loading of polymeric microspheres, composed of copolymers derived from fatty acid/amino acid components, as new polymeric platforms for antibiotic delivery systems. New polymeric materials were used to prepare microspheres with and without immobilized model antibiotics (streptomycin, chloramphenicol and amphotericin B) by a W/O/W double-emulsion/solvent evaporation method, in which chloroform and poly(vinyl alcohol) are used as the solvent and emulsifier, respectively...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28530283/composite-cd-mof-nanocrystals-containing-microspheres-for-sustained-drug-delivery
#9
Haiyan Li, Nana Lv, Xue Li, Botao Liu, Jing Feng, Xiaohong Ren, Tao Guo, Dawei Chen, J Fraser Stoddart, Ruxandra Gref, Jiwen Zhang
Metal-organic frameworks (MOFs), which are typically embedded in polymer matrices as composites, are emerging as a new class of carriers for sustained drug delivery. Most of the MOFs and the polymers used so far in these composites, however, are not pharmaceutically acceptable. In the investigation reported herein, composites of γ-cyclodextrin (γ-CD)-based MOFs (CD-MOFs) and polyacrylic acid (PAA) were prepared by a solid in oil-in-oil (s/o/o) emulsifying solvent evaporation method. A modified hydrothermal protocol has been established which produces efficiently at 50 °C in 6 h micron (5-10 μm) and nanometer (500-700 nm) diameter CD-MOF particles of uniform size with smooth surfaces and powder X-ray diffraction patterns that are identical with those reported in the literature...
May 22, 2017: Nanoscale
https://www.readbyqxmd.com/read/28528895/influence-of-perfluorocarbons-on-carbamazepine-and-benzodiazepine-for-a-neuro-lung-protective-strategy
#10
V Natchimuthu, Sabu Thomas, Murugan Ramalingam, S Ravi
Lennox-Gastaut syndrome (LGS) is commonly characterized by a triad of features including multiple seizure types, intellectual disability or regression. LGS type of seizures is epilepsy which is due to abnormal vibrations occurring in seizures. During the time of such abnormal vibrations, both the seizures and the lungs suffer a lack in oxygen content to a considerable extent. This results in prolonged vibrations and loses of nervous control. As a neuro-lung protective strategy, a novel attempt has been made to enrich both seizures and lungs with oxygen content through the support of Perfluorodecalin (an excellent oxygen carrier) C10F18 (PFD) and Perfluorohexane C6F14 (PFH) along with an enhancement in the antiepileptic activity by the two chosen antiepileptic drugs (AEDs) Carbamazepine (CBZ) and Benzodiazepine (BDZ)...
May 18, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28528850/overview-of-solidification-techniques-for-self-emulsifying-drug-delivery-systems-from-industrial-perspective
#11
J Mandić, A Zvonar Pobirk, F Vrečer, M Gašperlin
Self-emulsifying drug delivery systems (SEDDS) are lipid formulations that improve solubility and oral bioavailability of the incorporated drug with poor biopharmaceutical properties. As liquids they are traditionally filled into soft or hard capsules. Transformation of SEDDS into solid dosage form has been extensively investigated in the recent years because solid dosage forms improve stability, handling and patient compliance. By using different solidification techniques selfemulsifying powders, granules, pellets and tablets can be produced...
May 18, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28528111/protection-of-%C3%AE-carotene-from-chemical-degradation-in-emulsion-based-delivery-systems-using-antioxidant-interfacial-complexes-catechin-egg-white-protein-conjugates
#12
Luping Gu, Yujie Su, Mengqi Zhang, Cuihua Chang, Junhua Li, David Julian McClements, Yanjun Yang
The aim of the present study was to fabricate catechin-egg white protein (CT-EWP) conjugates as novel food-grade antioxidant emulsifiers designed to improve the physicochemical stability of β-carotene (BC) emulsions. CT-EWP conjugates were synthesized using free radical grafting, and the formation of conjugates was confirmed by electrophoresis and liquid chromatography-mass spectrometry. The physicochemical stability of BC emulsions was characterized by measuring alterations in particle size, ζ-potential and BC retention...
June 2017: Food Research International
https://www.readbyqxmd.com/read/28528089/production-of-highly-concentrated-oil-in-water-emulsions-using-dual-channel-microfluidization-use-of-individual-and-mixed-natural-emulsifiers-saponin-and-lecithin
#13
Xiang Luo, Yanyan Zhou, Long Bai, Fuguo Liu, Ruojie Zhang, Zipei Zhang, Bingjing Zheng, Yihui Deng, David Julian McClements
The fabrication of concentrated oil-in-water emulsions is useful for reducing storage and transportation costs, as well as for providing desirable textural, optical, stability, and release characteristics in commercial products. In this study, 50wt% oil-in-water emulsions were produced from natural emulsifiers using high-pressure dual-channel microfluidization (89.6MPa, 1 pass). The particle size and charge characteristics of emulsions stabilized using a hydrophilic biosurfactant (quillaja saponin) or mixtures of hydrophilic and hydrophobic biosurfactants (quillaja saponin+soy lecithin) were measured...
June 2017: Food Research International
https://www.readbyqxmd.com/read/28521998/co2-switchable-behavior-of-chitosan-g-poly-2-dimethylamino-ethyl-methacrylate-as-an-emulsifier
#14
Yeong-Tarng Shieh, Yen-Tzu Lin, Chih-Chia Cheng
Chitosan-g-poly[(2-dimethylamino)ethyl methacrylate] was investigated as a CO2-switchable emulsifier in this study. Poly(2-dimethylamino)ethyl methacrylate (PDMAEMA) was prepared by atom transfer radical polymerization followed by grafting to chitosan (CS). The CO2-responsiveness and reversible CO2-switchable temperature- and pH-sensitive behavior of PDMAEMA and CS-g-PDMAEMA were investigated as emulsifiers via simple CO2 and N2 bubbling. The lower critical solution temperatures (LCSTs) of PDMAEMA and CS-g-PDMAEMA aqueous solutions both increased as pH decreased to about pH 7...
August 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28516413/self-emulsification-of-lipidic-drug-delivery-system-in-pure-water-and-in-concentrated-glycerol-solution
#15
Carole Planchette, Annalisa Mercuri, Lorenzo Arcangeli, Manfred Kriechbaum, Peter Laggner
Self-emulsifying drug delivery systems (SEDDS), often intended for oral delivery, are normally explored in biorelevant aqueous media. The high complexity of these multi-component systems leaves the understanding of self-emulsification poor, hindering formulation rationalization. In this work, we aimed to fill this gap by studying the effects of glycerol on the self-emulsification of a ternary component formulation made of 20% w/w Tween 80, 15% w/w Span 80, and 65% w/w Captex 300 Low C6. The behavior of SEDDS in pure water and a binary mixture of water and glycerol (58...
May 17, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/28515639/influence-of-adding-recovered-protein-from-processing-wastewater-on-the-quality-of-mechanically-separated-chicken-meat-surimi-like-material
#16
William Renzo Cortez-Vega, Gustavo Graciano Fonseca, Daniela Cardozo Bagatini, Carlos Prentice
Functional and nutritional soluble proteins can be recovered from surimi (and surimi-like material) processing wastewater, reducing environmental problems and the cost of an irresponsible waste disposal. Recovered proteins may be added back at a low percentage to surimi products. The aim of this work was to evaluate the effect of the addition of soluble recovered proteins (RP), obtained from mechanically separated chicken meat surimi-like material (MSCM-SLM) processing wastewater by acidic pH-shifting, on the composition and texture of RP-MSCM-SLM, with RP contents of 0, 10, 20 and 30% (w/w) in the mixture...
2017: Korean Journal for Food Science of Animal Resources
https://www.readbyqxmd.com/read/28510456/thermoresponsive-pickering-emulsions-stabilized-by-silica-nanoparticles-in-combination-with-alkyl-polyoxyethylene-ether-nonionic-surfactant
#17
Yue Zhu, Ting Fu, Kaihong Liu, Qi Lin, Xiaomei Pei, Jianzhong Jiang, Zhenggang Cui, Bernard P Binks
We put forward a simple protocol to prepare thermoresponsive Pickering emulsions. Using hydrophilic silica nanoparticles in combination with a low concentration of alkyl polyoxyethylene monododecyl ether (C12En) nonionic surfactant as emulsifier, oil-in-water (o/w) emulsions can be obtained, which are stable at room temperature but demulsified at elevated temperature. The stabilization can be restored once the separated mixture is cooled and rehomogenized, and this stabilization-destabilization behavior can be cycled many times...
May 26, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28508436/bio-functional-properties-of-sardine-protein-hydrolysates-obtained-by-brewer-s-spent-yeast-and-commercial-proteases
#18
Elsa F Vieira, Olívia Pinho, Isabel Mplvo Ferreira
BACKGROUND: Canned sardine industry generates large amounts of protein rich waste, which demands a useful exploitation. This paper describes the potential use of muscle and viscera proteins from canned sardine by-products as substrate to obtain hydrolysates with biological and functional properties. Three enzymatic approaches, brewer's spent yeast (Bsy) proteases, Alcalase® and Neutrase® were applied to perform protein hydrolysis at the same proteolytic activity (1 U mL(-1) ), using an enzyme/substrate ratio of 20% (v/v), at 50 °C and for 7 h...
May 16, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28506870/development-of-solid-sedds-vii-effect-of-pore-size-of-silica-on-drug-release-from-adsorbed-self-emulsifying-lipid-based-formulations
#19
Suhas G Gumaste, Abu T M Serajuddin
PURPOSE: Lipid-based self-emulsifying drug delivery systems (SEDDS) are usually liquids, and they can be converted into solid dosage forms by adsorbing onto silicates. However, most commercially available silicates are mesoporous with small pore sizes of 1 to 50nm that lead to incomplete emulsification of SEDDS inside the pores and thus incomplete drug release. The objective of this study was to investigate the impact of silica pore size on the extent of drug release from SEDDS solidified by adsorbing onto macroporous silicas with different pore sizes...
May 12, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28505509/fungal-biocatalyst-activated-by-an-electric-field-improved-mass-transfer-and-non-specificity-for-hydrocarbon-degradation-in-an-airlift-bioreactor
#20
Victor Sánchez-Vázquez, Keiko Shirai, Ignacio González, Mariano Gutiérrez-Rojas
The combination of biological and electrochemical techniques enhances the bioremediation efficiency of treating oil-contaminated water. In this study a non-growing fungal whole cell biocatalyst (BC; Aspergillus brasiliensis attached to perlite) pretreated with an electric field (EF), was used to degrade a hydrocarbon blend (hexadecane-phenanthrene-pyrene; 100:1:1w/w) in an airlift bioreactor (ALB). During hydrocarbon degradation, all mass transfer resistances (internal and external) and sorption capacity were experimentally quantified...
May 3, 2017: Journal of Hazardous Materials
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