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Yau Kei Chan, Gabriela Czanner, Ho Cheung Shum, Rachel L Williams, Ning Cheung, David Wong
PURPOSE: Emulsification is related to complications arising from silicone oil (SO) tamponade. Currently, there is no widely accepted method for testing the propensity of SO to emulsify that are physiologically realistic and quantitative. METHODS: We compared different ways of inducing emulsification namely vortex mixing, sonication and homogenization. Silicone oil (SO) emulsification was quantitatively assessed using the Coulter counter and laser light scattering...
October 24, 2016: Acta Ophthalmologica
Subhash Chandra Bose Penjuri, Saritha Damineni, Nagaraju Ravouru, Srikanth Reddy Poreddy Reddy Poreddy
BACKGROUND: The objective of this investigation was to develop a self emulsifying drug delivery system (SEDDS) of naproxen, a poorly water soluble drug, which could improve its solubility and oral bioavailability. Methoda: The recent patents on SEDDS of abiraterone acetate (WO2014/009434 A1) and tamoxifen (WO2013/0080083) helped in selecting the naproxen and excipients. Phase diagrams were constructed and the formulations were taken from the micro emulsion region. Formulations were subjected to thermodynamic stability, dispersibility and precipitation tests for optimization...
October 19, 2016: Recent Patents on Drug Delivery & Formulation
Md Akhlaquer Rahman, Md Mujahid, Arshad Hussain
AIMS: The purpose of the current study was to investigate the feasibility of producing solid self-emulsifying pellets using the extrusion/spheronization technique with an aim to increase the bioavailability of selected drug and also to encounter the problems associated with liquid lipid formulations. Self-emulsifying formulations are experiencing a very active development as reflected by the numerous publications and patents being granted on these systems. The patents on self-emulsifying formulation (US20036630150) and (US20006054136) helped in selecting the drug and excipients...
October 21, 2016: Recent Patents on Drug Delivery & Formulation
Mira M Sachdeva, Frederick A Jakobiec, Anna M Stagner, Athanasios Papakostas, Dean Eliott
PURPOSE: Large relaxing retinectomies have become increasingly used in the repair of retinal detachment related to proliferative vitreoretinopathy (PVR). Retinectomies expose the retinal pigment epithelium (RPE) to the vitreous cavity; the direct effects of silicone oil on the RPE are only beginning to be understood. DESIGN: Retrospective case series. PARTICIPANTS: Twelve patients noted to develop pigmented epiretinal deposits at regularly scheduled follow-up visits after repair of complex retinal detachments using silicone oil tamponade and retinectomy...
October 18, 2016: Ophthalmology
Kelly Muijlwijk, Wenqian Huang, Jan-Eise Vuist, Claire Berton-Carabin, Karin Schroën
Surfactant adsorption during emulsification can be quantified by measuring the acting interfacial tension using a Y-junction microfluidic device. To obtain insight into the surfactant transport mechanism to the interface, the effect of shear force on the acting interfacial tension was assessed by systematically varying the continuous phase viscosity and velocity. Varying the continuous phase viscosity did not affect the acting interfacial tension, indicating that surfactant adsorption during Y-junction emulsification is not diffusion-limited...
October 21, 2016: Soft Matter
Eduardo Huber, Diego Lucas Francio, Vanessa Biasi, Natália Mezzomo, Sandra Regina Salvador Ferreira
ABSTRACT: Vegetable fibers have been used lately as ingredients in popular meat products in order to increase its nutritional value. The objective of this study was the physical-chemical characterization of six vegetable fibers in order to apply them in chicken burger formulations as animal fat substitutes. The studied fibers showed moisture content below 14 %, low content of fat, protein and ash, and high levels of carbohydrates. The oat, wheat and bamboo fibers showed the highest content of total dietary fiber...
July 2016: Journal of Food Science and Technology
Intidhar Bkhairia, Rabeb Ben Slama Ben Salem, Rim Nasri, Mourad Jridi, Sofiane Ghorbel, Moncef Nasri
Bioactive Liza aurata protein hydrolysates (LAPHs) were prepared by treatment with Trypsine (PH-TR), Esperase (PH-ES), enzyme preparations from Pseudomonas aeruginosa A2 (PH-A2), Bacillus subtilis A26 (PH-A26) and Liza aurata (PH-LA). Their functional properties and antioxidant activities were evaluated. The hydrolysates had degree of hydrolysis (DH) values ranging from 8.15 % to 13.05 %. Reverse-phase HPLC analyses of the LAPHs showed considerable variation in peptide composition. All hydrolysates had high protein content (83...
July 2016: Journal of Food Science and Technology
Saehun Mun, Jisu Kim, David Julian McClements, Yong-Ro Kim, Yongdoo Choi
A whey protein isolate-rhodamine B conjugate (WPI-RB) was synthesized to visualize changes in the location of a protein emulsifier in oil-in-water emulsions during digestion. An oil-soluble dye (Nile Red) was used to visualize changes in the lipid phase during digestion. Protein-labeled and lipid-labeled emulsions were passed through a simulated gastrointestinal tract consisting of mouth, stomach, and intestinal phases, and changes in protein and lipid location and morphology were monitored using confocal laser scanning microscopy...
March 15, 2017: Food Chemistry
Yung-Hao Liu, Pai-Shan Chen, Shang-Da Huang
Shaker-assisted dispersive liquid-liquid microextraction (SA-DLLME) and surfactant dispersive liquid-liquid microextraction (SDLLME) have been developed to determine five diphenylether herbicides in water samples using high-performance liquid chromatography with photodiode array detection (HPLC-PDA). For SA-DLLME, an up-and-down shaker-assisted emulsification was used. Extraction was complete in 3 min. Only 30 μL of decyl acetate was required, without a dispersive solvent. The linear range was from 2 to 1000 μg L(-1), the coefficient of determination (r (2)) was better than 0...
October 19, 2016: Journal of AOAC International
Samuel A Einstein, Bradley P Weegman, Meri T Firpo, Klearchos Papas, Michael Garwood
Techniques to monitor the oxygen partial pressure (pO<sub>2</sub>) within implanted tissue-engineered grafts (TEGs) are critically necessary for TEG development, but current methods are invasive and inaccurate. In this study, we investigated an accurate and noninvasive technique to monitor TEG pO<sub>2</sub> utilizing proton (<sup>1</sup>H) or fluorine (<sup>19</sup>F) magnetic resonance spectroscopy (MRS) relaxometry. The value of the spin-lattice relaxation rate constant (R<sub>1</sub>) of some biocompatible compounds is sensitive to dissolved oxygen (and temperature), while insensitive to other external factors...
October 19, 2016: Tissue Engineering. Part C, Methods
Imran Rashid, Nathalie Moiré, Bruno Héraut, Isabelle Dimier-Poisson, Marie-Noëlle Mévélec
Infection with the parasite Toxoplasma gondii causes serious public health problems and is of great economic importance worldwide. No vaccine is currently available, so the design of efficient vaccine strategies is still a topical question. In this study, we evaluated the immunoprophylactic potential of a T. gondii virulence factor, the rhoptry kinase ROP18, in a mouse model of chronic toxoplasmosis: first using a recombinant protein produced in Schneider insect cells adjuvanted with poly I:C emulsified in Montanide SV71 by a parenteral route or adjuvanted with cholera toxin by the nasal route and second using a DNA plasmid encoding ROP18 adjuvanted with GM-CSF ± IL-12 DNA...
October 18, 2016: Medical Microbiology and Immunology
Jing Li, Tengfei Fan, Yong Xu, Xuemin Wu
Emulsifiers for pesticide microemulsions contain a part of volatile organic compounds (VOCs), and ionic liquids (ILs) are becoming potential substitutes. In order to apply ILs in pesticide microemulsions, the study of interaction between ILs and surfactants is necessary. Therefore, the surface properties and aggregation of anionic surfactant sodium dodecyl sulfate (SDS) in ILs, including N-hexyl-N-methylmorpholinyl bromide ([C6mm][Br]), N-hexyl-N-methylpiperidyl bromide ([C6mp][Br]), N-hexyl-N-methylpyrrolidyl bromide ([C6mpyr][Br]), N-octyl-N-methylpyrrolidyl bromide ([C8mpyr][Br]), N-dodecyl-N-methylpyrrolidyl bromide ([C12mpyr][Br]) and N-hexadecyl-N-methylpyrrolidyl bromide ([C16mpyr][Br]), were investigated in terms of surface tension, conductivity, dynamic light scattering (DLS), viscosity, fluorescence, pseudo-ternary phase diagram and (1)H NMR measurements...
October 19, 2016: Physical Chemistry Chemical Physics: PCCP
L A Trujillo-Cayado, M C Alfaro, M C García, J Muñoz
In recent years, interest in submicron emulsions has increased due to their high stability and potential applications in the encapsulation and release of active ingredients in many industrial fields, such as the food industry, pharmaceuticals or agrochemicals. Furthermore, the social demand for eco-friendly solutions to replace hazardous solvents in many dispersion formulations has steadily risen. In this study, the influence of surfactant concentration on the formation and physical stability of submicron oil-in-water emulsions using a high-pressure dual-channel homogenizer (microfluidizer) has been investigated...
October 11, 2016: Colloids and Surfaces. B, Biointerfaces
Chao Zhang, Runqiang Liu, Jun He, Zhiqing Ma, Xing Zhang
In order to develop novel botanical insecticides, the joint action of Ligusticum chuanxiong oil (LCO) and lemongrass oil (LO) against Aphis citricola van der Goot was determined systematically indoors and outdoors. The chemical profiles of LCO and LO as determined by gas chromatography-mass spectrometry (GC-MS) analysis revealed that the main compounds from LCO were (Z)-ligustilide (44.58%) and senkyunolide A (26.92%), and that of LO were geranial (42.16%) and neral (32.58%), respectively. The mixture of LCO and LO showed significant synergy against A...
October 12, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Sun-Hyung Kim, Yeun-Sun Ji, Eui-Seok Lee, Soon-Taek Hong
Curcumin is a flavonoid found in the rhizome of the turmeric plant (Curcuma longa L.) and has recently attracted interest because it has numerous biological functions and therapeutic properties. In the present study, we attempted to incorporate curcumin into medium-chain triglyceride (MCT) nanoemulsions (0.15 wt% curcumin, 10 wt% MCT oil, and 10 wt% emulsifiers) with various emulsifiers [polyoxyethylene (20) sorbitan monolaurate (Tween-20), sorbitan monooleate (SM), and soy lecithin (SL)]. The physicochemical properties of the nanoemulsions including the Ostwald ripening stability were investigated...
September 2016: Preventive Nutrition and Food Science
Xiantao Shen, Chuixiu Huang, Sudhirkumar Shinde, Kishore Kumar Jagadeesan, Simon Ekström, Emelie Fritz, Börje Sellergren
This work describes the preparation and investigation of molecularly imprinted polymer (MIP) microgels (MGs) stabilized Pickering emulsions (PE) for their ability to catalyze the formation of disulfide bonds in peptides at the O/W interface. The MIP MGs were synthesized via precipitation polymerization and a programmed initiator change strategy. The MIP MGs were characterized using DLS analysis, SEM measurement and optical microscopy analysis. The dry and wet MIP MGs showed a hydrodynamic diameter of 100 nm and 280 nm, respectively...
October 17, 2016: ACS Applied Materials & Interfaces
David A Riehm, David J Rokke, Prakash G Paul, Han Seung Lee, Brent S Vizanko, Alon V McCormick
Lecithin-rich mixtures of the nontoxic surfactants lecithin and Tween 80 are effective marine oil spill dispersants, but produce much higher oil-water interfacial tension than other, comparably effective dispersants. This suggests interfacial phenomena other than interfacial tension influence lecithin-Tween 80 dispersants' effectiveness. The interface between seawater and dispersant-crude oil mixtures was studied using light microscopy, cryogenic scanning electron microscopy, and droplet coalescence tests. Lecithin:Tween 80 ratio was varied from 100:0 to 0:100 and wt% dispersant in the oil was varied from 1...
October 5, 2016: Journal of Colloid and Interface Science
Mir Mahdi Zahedi, Ahmad Rezaei
After complexation of Cr(III) and Cr(VI) species with diethyldithiocarbamate (0.2 mmol/L), effective parameters of emulsification-based dispersive liquid microextraction procedure was optimized for its preconcentration in artificial seawater. Triton X-305 as the emulsifying disperser and mixture of the chloroform and carbon tetrachloride as the extraction solvents show a better behavior at sample pH of 6.5. The method was applied for extraction and UV detection (λ = 254 nm) of chromium species of the Chabahar Bay seawater prior to high-performance liquid chromatography (conditions: C18, methanol: acetic acid solution 2% v (85:15), flow rate of 0...
October 13, 2016: Journal of Chromatographic Science
Christopher A Seid, Kathryn M Jones, Jeroen Pollet, Brian Keegan, Elissa Hudspeth, Molly Hammond, Junfei Wei, C Patrick McAtee, Leroy Versteeg, Amanda Gutierrez, Zhuyun Liu, Bin Zhan, Jonathan L Respress, Ulrich Strych, Maria Elena Bottazzi, Peter J Hotez
A therapeutic vaccine for human Chagas disease is under development by the Sabin Vaccine Institute Product Development Partnership. The aim of the vaccine is to significantly reduce the parasite burden of Trypanosoma cruzi in humans, either as a standalone product or in combination with conventional chemotherapy. Vaccination of mice with Tc24 formulated with monophosphoryl-lipid A (MPLA) adjuvant results in a Th1 skewed immune response with elevated IgG2a and IFNγ levels and a statistically significant decrease in parasitemia following T...
October 13, 2016: Human Vaccines & Immunotherapeutics
Juntao Yin, Cuiyu Xiang, Guangxiu Lu
Palmatine (PM) is a potent anti-infective agent used to treat eye diseases. However, PM is less effective for ocular application due to short residence time within the eyes. This study aimed to develop a cationic lipid emulsions (CLEs) for ophthalmic delivery of PM and evaluate its suitability in infection treatment. PM-loaded CLEs (PM-CLEs) were prepared through emulsifying/high pressure homogenization and characterized by particle size, ζ potential and morphology. The resulting PM-CLEs possessed a particle size of 192 nm and ζ potential of 45 mV around...
October 13, 2016: Journal of Microencapsulation
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