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Iris L A Bodewes, Erika Huijser, Cornelia G van Helden-Meeuwsen, Liselotte Tas, Ruth Huizinga, Virgil A S H Dalm, P Martin van Hagen, Noortje Groot, Sylvia Kamphuis, Paul L A van Daele, Marjan A Versnel
OBJECTIVE: Upregulation of type I interferons (IFN-I) is a hallmark of systemic autoimmune diseases like primary Sjögren's syndrome (pSS), systemic lupus erythematosus (SLE) and systemic sclerosis (SSc). Expression of IFN-I is induced by three different receptor families: Toll-like receptors (TLRs), RIG-like receptors (RLRs) and DNA-sensing receptors (DSRs). TANK-binding kinase (TBK1) is an important signaling hub downstream of RLRs and DSRs. TBK1 activates IRF3 and IRF7, leading to IFN-I production and subsequent induction of interferon stimulated genes (ISGs)...
July 2018: Journal of Autoimmunity
James D Weinstein
Despite decades of research, at present there is no curative therapy for Alzheimer's disease. Changes in the way new drugs are tested appear to be necessary. Three changes are presented here and will be discussed. The first change is that Alzheimer's disease must be considered a disease of four major pathological processes, not one. The four processes are: 1) vascular hypoperfusion of the brain with associated mitochondrial dysfunction, 2) destructive protein inclusions, 3) uncontrolled oxidative stress, and 4) proinflammatory immune processes secondary to microglial and astrocytic dysfunction in the brain...
February 2018: Neural Regeneration Research
Pan Wang, Kangjun Zhao, Xiaosheng Xiao, Changxi Yang
We report on the first demonstration of dual-wavelength square-wave pulses in a thulium-doped fiber laser. Under appropriate cavity parameters, dual-wavelength dissipative soliton resonances (DSRs) and domain wall solitons (DWSs) are successively obtained. Meanwhile, dark pulses generation is achieved at the dual-wavelength DWSs region due to the overlap of the two domain wall pulses. The fiber-based Lyot filter, conducted by inserting PMF between an in-line PBS and a PD-ISO, facilitates the generation of dual-wavelength operation...
November 27, 2017: Optics Express
Zhen Li, Shengjuan Wei, Hejun Li, Keliang Wu, Zhaowei Cai, Dongfeng Li, Wei Wei, Qifa Li, Jie Chen, Honglin Liu, Lifan Zhang
As typical Chinese indigenous pig breeds, Erhualian and Meishan have been widely used to produce new strain or breed in the world. However, the genetic basis of characteristics of these pig breeds is still limited. Moreover, considering cost and output of sequencing, it is necessary to further develop cost-effective method for pig genome screening. To contribute on this issue, we developed a SLAF-seq (specific-locus amplified fragment sequencing) method for pigs and applied it to analyze the genetic difference among Landrace, Erhualian, and Meishan pigs...
August 30, 2017: Scientific Reports
Berton R Moed, Heidi A Israel
INTRODUCTION: The purposes of this study were to determine the current attitude of orthopaedic trauma surgeons toward device sales representatives (DSRs), especially regarding their presence in the operating room (OR), and to establish the existence of any surgeon generational differences. METHODS: A survey was created using a 5-point Likert response scale, related to conflict of interest (COI) and attitudes toward DSRs. Participants were solicited from the Orthopaedic Trauma Association database of 384 active members and 127 (33%) completed the survey...
September 2017: Journal of Orthopaedic Trauma
Zihnet Selimbasic, Osman Sinanovic, Esmina Avdibegovic, Maja Brkic, Jasmin Hamidovic
INTRODUCTION: Behavioral problems and emotional difficulties at children of the veterans of war with post-traumatic stress disorder (PTSD) have not been researched entirely. In our country, which has a lot of persons suffering from some psychological traumas, this trauma seems to continue. AIM: The aim of this study was to determine the exposure, manifestations of behavioral problems and emotional difficulties at children and early adolescents, whose fathers were the veterans of war demonstrating post-traumatic stress disorder symptoms...
February 2017: Medical Archives
H Essa, D H Vasant, A Raginis-Zborowska, A Payton, E Michou, S Hamdy
BACKGROUND: The aim of this study was to explore the effect of brain-derived neurotrophic factor (BDNF) polymorphism rs6265 (Val66Met) in both "natural" and treatment induced recovery of swallowing after dysphagic stroke. METHODS: Sixteen dysphagic stroke patients that completed a single-blind randomized sham controlled trial of pharyngeal electrical stimulation (PES) within 6 weeks of their stroke (N=38), were genotyped for the BDNF SNP Val66Met (rs6265) from saliva samples...
March 20, 2017: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
Xu Luo, Yu-Ze Zhao, Jing Ma, Jian-Qiang Li, Ji-Liang Xu
To explore the nest survival rate of Reeves's pheasant( Syrmaticus reevesii ) and the nest-site factors that affect it, we conducted artificial nest experiments with reference to natural nests at Dongzhai National Nature Reserve(DNNR), Henan Province and Pingjingguan, Hubei Province from April to June 2014 simulating the situation in its early and later breeding season. We also determined distance characteristics of the nest sites by ArcGIS 10.0. Nest survival models were constructed in Program MARK for data analysis...
January 18, 2017: Zoological Research
Lei Yin, Kevin Yu, Simon Lin, Xiao Song, Xiaozhong Yu
The potential adverse health effects of mercury from amalgam and bisphenol A (BPA) from composite resin have been significant concerns. It is unclear whether dental restorative materials significantly contribute to mercury or BPA levels. The purpose of this study is to use NHANES data including 14,703 subjects (2003-2004: n=7514; 2011-2012: n=7189) to examine the association between Dental Surface Restorations (DSR) and blood total mercury (THg), inorganic mercury (IHg), methyl mercury (MeHg) and urinary BPA through the stratification of covariates and multivariate analysis...
December 2016: Ecotoxicology and Environmental Safety
Frances A Stillman, Andrea Soong, Yuanjie Pang, Laura Zheng, Esther Garcia-Esquinas, Maria Jose Lopez, Ana Navas-Acien
Objective: Conduct a systematic evaluation of indoor and outdoor areas of selected airports, assess compliance and identify areas of improvement with smoke-free policies in airports. Methods: Cross-sectional observational study conducted at 21 airports in Europe (11) and the United States (10). Using a standardized protocol, we assessed compliance (smoking, cigarette butts, smoke smell), and the physical environment (signage, ashtrays, designated smoking rooms [DSRs], tobacco sales)...
November 7, 2017: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
Tsuyoshi Sasaki, Kenji Hashimoto, Yasunori Oda, Tamaki Ishima, Madoka Yakita, Tsutomu Kurata, Masaru Kunou, Jumpei Takahashi, Yu Kamata, Atsushi Kimura, Tomihisa Niitsu, Hideki Komatsu, Tadashi Hasegawa, Akihiro Shiina, Tasuku Hashimoto, Nobuhisa Kanahara, Eiji Shimizu, Masaomi Iyo
OBJECTIVE: 'Treatment-resistant depression' is depression that does not respond to an adequate regimen of evidence-based treatment. Treatment-resistant depression frequently becomes chronic. Children with treatment-resistant depression might also develop bipolar disorder (BD). The objective of this study was to determine whether serum levels of oxytocin (OXT) in treatment-resistant depression in adolescents (TRDIA) differ from non-treatment-resistant depression in adolescents (non-TRDIA) or controls...
2016: PloS One
Zhi Qu, Lue Ping Zhao, Xiemin Ma, Siyan Zhan
BACKGROUND There is increasing interest in clinical research with electronic medical data, but it often faces the challenges of heterogeneity between hospitals. Our objective was to develop a single numerical score for characterizing such heterogeneity via computing inpatient mortality in treating acute myocardial infarction (AMI) patients based on diagnostic information recorded in the database of Discharge Summary Reports (DSR). MATERIAL AND METHODS Using 4 216 135 DSRs of 49 tertiary hospitals from 2006 to 2010 in Beijing, more than 200 secondary diagnoses were identified to develop a risk score for AMI (n=50 531)...
June 19, 2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
Sofia Vadlin, Cecilia Åslund, Charlotta Hellström, Kent W Nilsson
The aim of the present study was to investigate associations between problematic gaming and psychiatric symptoms among adolescents. Data from adolescents in the SALVe cohort, including adolescents in Västmanland who were born in 1997 and 1999 (N=1868; 1034 girls), and data from consecutive adolescent psychiatric outpatients in Västmanland (N=242; 169 girls) were analyzed. Adolescents self-rated on the Gaming Addiction Identification Test (GAIT), Adult ADHD Self-Report Scale Adolescent version (ASRS-A), Depression Self-Rating Scale Adolescent version (DSRS-A), Spence Children's Anxiety Scale (SCAS), and psychotic-like experiences (PLEs)...
October 2016: Addictive Behaviors
Amanda S Newton, Kassi Shave, Rhonda J Rosychuk
PURPOSE: To identify geographic areas in Alberta, Canada with higher numbers of adolescents with an emergency department (ED) presentation for a mental or behavioral disorder secondary to alcohol and other drug use. METHODS: A population-based cohort analysis of ED visits (n = 7787) by adolescents aged 15-17 years (n = 7238) during 2002-2011. We calculated sex-adjusted directly standardized rates (DSRs) and identified space-time clusters in health zones (North, Edmonton, Calgary, Central, and South)...
July 28, 2016: Substance Use & Misuse
Orlando Luis de Andrade Santarém, Roberto de Cleva, Flávia Megumi Sasaya, Marianna Siqueira de Assumpção, Meive Santos Furtado, Alfonso Julio Guedes Barbato, Paulo Herman
OBJECTIVE: The aim of this study was to prospectively investigate the long-term cardiovascular and pulmonary hemodynamic effects of surgical shunt for treatment of portal hypertension (PH) due to Schistosomiasis mansoni. LOCATION: The University of São Paulo Medical School, Brazil; Public Practice. METHODS: Hemodynamic evaluation was performed with transesophageal Doppler and contrast-enhanced echocardiography (ECHO) on twenty-eight participants with schistosomal portal hypertension...
2016: PloS One
Katrina L Williams, Nancy L Low Choy, Sandra G Brauer
OBJECTIVES: To explore differences in gait endurance, speed, and standing balance in people with multiple sclerosis (MS) across the Disease Step Rating Scale, and to determine if differences are statistically significant and clinically meaningful. DESIGN: Observational study. SETTING: Community rehabilitation - primary health care center. PARTICIPANTS: Community-dwelling people with MS (N=222; mean age, 48±12y; 32% men)...
September 2016: Archives of Physical Medicine and Rehabilitation
Yusong Pan, Ming Yang, Yumei Li, Zhenhua Wang, Chunling Zhang, Ying Zhao, Jianghong Yao, Qiang Wu, Jingjun Xu
Deep sub-wavelength ripples (DSRs) and near sub-wavelength ripples (NSRs) with uniform periods of ~160 nm and ~660 nm generated at the MoS2-vacuum interface is reported for the first time by the processing of femtosecond laser (800 nm, 120 fs, 1 kHz) in this paper. The DSRs and NSRs formation fluence thresholds are experimentally determined as 160 mJ/cm(2) and 192 mJ/cm(2), respectively. In addition, the ripple period is insensitive to the pulse number. Moreover, Raman analyses show that the MoS2 lattice in the irradiated area does not exhibit oxidation at room environment and the crystalline representation is well preserved in NSRs region...
2016: Scientific Reports
Polly Scutt, Han S Lee, Shaheen Hamdy, Philip M Bath
Background. Dysphagia after stroke is common, associated independently with poor outcome, and has limited treatment options. Pharyngeal electrical stimulation (PES) is a novel treatment being evaluated for treatment of poststroke dysphagia. Methods. We searched electronically for randomised controlled trials of PES in dysphagic patients within 3 months of stroke. Individual patient data were analysed using regression, adjusted for trial, age, severity, and baseline score. The coprimary outcomes were radiological aspiration (penetration aspiration score, PAS) and clinical dysphagia (dysphagia severity rating scale, DSRS) at 2 weeks; secondary outcomes included functional outcome, death, and length of stay in hospital...
2015: Stroke Research and Treatment
Grazia Antonella Cannone, Maria Giovanna Burgio Lo Monaco, Simona Carone, Anna Melcarne, Margherita Tanzarella, Lucia Bisceglia, Antonino Ardizzone, Sante Minerba, Fabrizio Quarta, Vincenzo Coviello
OBJECTIVES: to investigate, for the first time, the incidence rates of malignant childhood cancers (children aged 0-14 years) in Apulia Region (Southern Italy) in the period 2003-2008. DESIGN: to compute incidence rates of childhood cancers from Apulia Region Cancer Registry database compared with the corresponding results published in 2012 by the Italian cancer registries network (AIRTUM),where data from the Apulia population were not included, because not available...
2015: Epidemiologia e Prevenzione
Xie-Min Ma, Xiao-Hong Chen, Ji-Shan Wang, Gary H Lyman, Zhi Qu, Wen Ma, Jing-Chen Song, Chuan-Kun Zhou, Lue Ping Zhao
Healthcare reforms (HR) initiated by many countries impacts on healthcare systems worldwide. Being one of fast developing countries, China launched HR in 2009. Better understanding of its impact is helpful for China and others in further pursuit of HR. Here we evaluate inpatient mortality, a proxy to healthcare quality, in 43 top tertiary hospitals in China during this critical period. This is a hospital-based observational study with 8 million discharge summary reports (DSR) from 43 Chinese hospitals from 2010-2012...
2015: PloS One
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