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Dementia severity rating scale

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https://www.readbyqxmd.com/read/28320196/extended-timed-up-and-go-assessment-as-a-clinical-indicator-of-cognitive-state-in-parkinson-s-disease
#1
Tess Evans, Alexa Jefferson, Michelle Byrnes, Sue Walters, Soumya Ghosh, Frank L Mastaglia, Brian Power, Ryan S Anderton
OBJECTIVE: To evaluate a modified extended Timed Up and Go (extended-TUG) assessment against a panel of validated clinical assessments, as an indicator of Parkinson's disease (PD) severity and cognitive impairment. METHODS: Eighty-seven participants with idiopathic PD were sequentially recruited from a Movement Disorders Clinic. An extended-TUG assessment was employed which required participants to stand from a seated position, walk in a straight line for 7m, turn 180° and then return to the start, in a seated position...
April 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28288263/neurofibrillary-tangle-stage-and-the-rate-of-progression-of-alzheimer-symptoms-modeling-using-an-autopsy-cohort-and-application-to-clinical-trial-design
#2
Jing Qian, Bradley T Hyman, Rebecca A Betensky
Importance: The heterogeneity of rate of clinical progression among patients with Alzheimer disease leads to difficulty in providing clinical counseling and diminishes the power of clinical trials using disease-modifying agents. Objective: To gain a better understanding of the factors that affect the natural history of progression in Alzheimer disease for the purpose of improving both clinical care and clinical trial design. Design, Setting, and Participants: A longitudinal cohort study of aging from 2005 to 2014 in the National Alzheimer Coordinating Center...
March 13, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28275701/sleep-wake-cycle-disturbances-in-elderly-acute-general-medical-inpatients-longitudinal-relationship-to-delirium-and-dementia
#3
James M FitzGerald, Niamh O'Regan, Dimitrios Adamis, Suzanne Timmons, Colum P Dunne, Paula T Trzepacz, David J Meagher
INTRODUCTION: Sleep disturbances in elderly medical inpatients are common, but their relationship to delirium and dementia has not been studied. METHODS: Sleep and delirium status were assessed daily for a week in 145 consecutive newly admitted elderly acute general hospital patients using the Delirium Rating Scale-Revised-98 (DRS-R98), Diagnostic and Statistical Manual 5, and Richards-Campbell Sleep Quality Scale measures. The longitudinal relationship between DRS-R98 and Richards-Campbell Sleep Quality Scale sleep scores and delirium, also with dementia as a covariate, was evaluated using generalized estimating equation logistic regression...
2017: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://www.readbyqxmd.com/read/28260547/surrogate-inaccuracy-in-predicting-older-adults-desire-for-life-sustaining-interventions-in-the-event-of-decisional-incapacity-is-it-due-in-part-to-erroneous-quality-of-life-assessments
#4
Gina Bravo, Modou Sene, Marcel Arcand
BACKGROUND: Family members are often called upon to make decisions for an incapacitated relative. Yet they have difficulty predicting a loved one's desire to receive treatments in hypothetical situations. We tested the hypothesis that this difficulty could in part be explained by discrepant quality-of-life assessments. METHODS: The data come from 235 community-dwelling adults aged 70 years and over who rated their quality of life and desire for specified interventions in four health states (current state, mild to moderate stroke, incurable brain cancer, and severe dementia)...
March 6, 2017: International Psychogeriatrics
https://www.readbyqxmd.com/read/28239906/complementary-medicine-for-treatment-of-agitation-and-delirium-in-older-persons-a-systematic-review-and-narrative-synthesis
#5
REVIEW
Ilana Levy, Samuel Attias, Eran Ben-Arye, Boaz Bloch, Elad Schiff
BACKGROUND: Agitation and delirium frequently occur in cognitively impaired older people. We conducted a systematic review with narrative synthesis of the literature aiming to assess effectiveness of complementary and alternative medicine (CAM) modalities to address these conditions. METHODS: Following preliminary search, we included 40 original researches on CAM treatment of delirium and agitation in older persons. Then, the quality of these studies was assessed using the Downs and Black Checklist and Quality Assessment Tool for Studies with Diverse Designs, and the effect sizes were calculated...
February 26, 2017: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28222815/cognitive-stimulation-therapy-as-a-sustainable-intervention-for-dementia-in-sub-saharan-africa-feasibility-and-clinical-efficacy-using-a-stepped-wedge-design
#6
Stella-Maria Paddick, Sarah Mkenda, Godfrey Mbowe, Aloyce Kisoli, William K Gray, Catherine L Dotchin, Laura Ternent, Adesola Ogunniyi, John Kissima, Olaide Olakehinde, Declare Mushi, Richard W Walker
BACKGROUND: Cognitive stimulation therapy (CST) is a psychosocial group-based intervention for dementia shown to improve cognition and quality of life with a similar efficacy to cholinesterase inhibitors. Since CST can be delivered by non-specialist healthcare workers, it has potential for use in low-resource environments, such as sub-Saharan Africa (SSA). We aimed to assess the feasibility and clinical effectiveness of CST in rural Tanzania using a stepped-wedge design. METHODS: Participants and their carers were recruited through a community dementia screening program...
February 22, 2017: International Psychogeriatrics
https://www.readbyqxmd.com/read/28182110/a-preliminary-study-of-patient-dignity-inventory-validation-among-patients-hospitalized-in-an-acute-psychiatric-ward
#7
Rosaria Di Lorenzo, Giulio Cabri, Eleonora Carretti, Giacomo Galli, Nina Giambalvo, Giulia Rioli, Serena Saraceni, Giulia Spiga, Cinzia Del Giovane, Paola Ferri
PURPOSE: To investigate the perception of dignity among patients hospitalized in a psychiatric setting using the Patient Dignity Inventory (PDI), which had been first validated in oncologic field among terminally ill patients. PATIENTS AND METHODS: After having modified two items, we administered the Italian version of PDI to all patients hospitalized in a public psychiatric ward (Service of Psychiatric Diagnosis and Treatment of a northern Italian town), who provided their consent and completed it at discharge, from October 21, 2015 to May 31, 2016...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28128435/vitamin-e-for-alzheimer-s-dementia-and-mild-cognitive-impairment
#8
REVIEW
Nicolas Farina, David Llewellyn, Mokhtar Gad El Kareem Nasr Isaac, Naji Tabet
BACKGROUND: Vitamin E occurs naturally in the diet. It has several biological activities, including functioning as an antioxidant to scavenge toxic free radicals. Evidence that free radicals may contribute to the pathological processes behind cognitive impairment has led to interest in the use of vitamin E supplements to treat mild cognitive impairment (MCI) and Alzheimer's disease (AD). This is an update of a Cochrane Review first published in 2000, and previously updated in 2006 and 2012...
January 27, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28124590/a-multicentre-italian-validation-study-in-aging-adults-with-down-syndrome-and-other-forms-of-intellectual-disabilities-dementia-screening-questionnaire-for-individuals-with-intellectual-disabilities
#9
Tiziano Gomiero, Marco Bertelli, Shoumitro Deb, Elisabeth Weger, Annachiara Marangoni, Elisa De Bastiani, Ulrico Mantesso, Luc Pieter De Vreese
BACKGROUND: The USA National Task Group (NTG) guidelines advocate the use of an adapted version of Dementia Screening Questionnaire for Individuals with Intellectual Disabilities (DSQIID) for dementia screening of individuals with Down syndrome (DS) and with other forms of ID (non-DS). OBJECTIVE: In order to meet these guidelines, this study verifies the psychometric properties of an Italian version of the original DSQIID in a population composed of adults aged 40 years and over with DS and non-DS ID...
January 16, 2017: Current Alzheimer Research
https://www.readbyqxmd.com/read/28116342/subsyndromal-delirium-compared-with-delirium-dementia-and-subjects-without-delirium-or-dementia-in-elderly-general-hospital-admissions-and-nursing-home-residents
#10
Esteban Sepulveda, Maeve Leonard, Jose G Franco, Dimitrios Adamis, Geraldine McCarthy, Colum Dunne, Paula T Trzepacz, Ana M Gaviria, Joan de Pablo, Elisabet Vilella, David J Meagher
INTRODUCTION: Subsyndromal delirium (SSD) complicates diagnosis of delirium and dementia, although there is little research comparing their symptom profiles. METHODS: Cross-sectional study of 400 elderly patients' admission to a general hospital or nursing home diagnosed with delirium, SSD, dementia, or no-delirium/no-dementia (NDND). Symptom profiles were assessed using the Delirium Rating Scale-Revised-98 (DRS-R98). RESULTS: Twenty percent patients had delirium, 19...
2017: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://www.readbyqxmd.com/read/28106550/factors-underpinning-caregiver-burden-in-frontotemporal-dementia-differ-in-spouses-and-their-children
#11
Cassandra Kaizik, Jashelle Caga, Julieta Camino, Claire M O'Connor, Colleen McKinnon, Jan R Oyebode, Olivier Piguet, John R Hodges, Eneida Mioshi
The objectives of this observational study were to (1) compare spousal and child caregiver burden; (2) compare co-resident and live-out child caregiver burden; and (3) investigate factors influencing spousal and child caregiver burden. Data was collected from 90 caregivers of people with frontotemporal degeneration (FTD) recruited from the Frontotemporal Dementia Research Group (Frontier) at Neuroscience Research, Australia. Of this caregiver group, 43 were spousal caregivers and 47 were child caregivers. Caregiver burden and emotional state were evaluated using the short Zarit Burden Interview and the short version of the Depression, Anxiety and Stress Scale-21...
2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28095946/electroconvulsive-therapy-ect-for-treating-agitation-in-dementia-major-neurocognitive-disorder-a-promising-option
#12
Oliver M Glass, Brent P Forester, Adriana P Hermida
BACKGROUND: Agitation in patients with dementia increases caretaker burden, increases healthcare costs, and worsens the patient's quality of life. Antipsychotic medications, commonly used for the treatment of agitation in patients with dementia have a box warning from the FDA for elevated mortality risk. Electroconvulsive therapy (ECT) has made significant advances over the past several years, and is efficacious in treating a wide range of psychiatric conditions. We provide a systematic review of published literature regarding the efficacy of ECT for the treatment of agitation in patients with dementia (major neurocognitive disorder)...
January 18, 2017: International Psychogeriatrics
https://www.readbyqxmd.com/read/28093795/natural-history-of-pure-autonomic-failure-a-united-states-prospective-cohort
#13
Horacio Kaufmann, Lucy Norcliffe-Kaufmann, Jose-Alberto Palma, Italo Biaggioni, Phillip A Low, Wolfgang Singer, David S Goldstein, Amanda C Peltier, Cyndia A Shibao, Christopher H Gibbons, Roy Freeman, David Robertson
OBJECTIVE: To define the clinical features and biomarkers that predict which patients with pure autonomic failure will develop Parkinson disease, dementia with Lewy bodies, or multiple system atrophy. METHODS: One hundred patients who presented with pure autonomic failure were recruited at 5 medical centers in the United States. Seventy-four patients agreed to be followed prospectively. Patients underwent clinical evaluations including neurological rating scales, sleep questionnaires, smell test, and sympathetic and parasympathetic cardiovascular autonomic function tests...
February 2017: Annals of Neurology
https://www.readbyqxmd.com/read/28069027/reliability-of-health-related-quality-of-life-assessments-made-by-older-adults-and-significant-others-for-health-states-of-increasing-cognitive-impairment
#14
Gina Bravo, Modou Sene, Marcel Arcand
BACKGROUND: Older adults are encouraged by many organizations to engage in advance care planning in the event of decisional incapacity. Planning for future health care often involves anticipating health-related quality of life (HRQoL) in states of reduced cognitive functioning. No study has yet examined whether anticipated HRQoL is stable over time. The accuracy with which significant others can predict how an older adult envisions HRQoL in a future state of cognitive impairment is also unknown...
January 7, 2017: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/28067961/quality-of-life-in-relation-to-neuropsychiatric-symptoms-in-alzheimer-s-disease-5-year-prospective-alsova-cohort-study
#15
Kristiina Hongisto, Ilona Hallikainen, Tuomas Selander, Soili Törmälehto, Saku Väätäinen, Janne Martikainen, Tarja Välimäki, Sirpa Hartikainen, Jaana Suhonen, Anne M Koivisto
OBJECTIVE: To examine the association between neuropsychiatric symptoms (NPS) with self- and caregiver-rated Quality of Life (QoL) for patients with Alzheimer's disease (AD) during a 5-year follow-up. METHODS: The ALSOVA 5-year follow-up study included, at baseline, 236 patients with either very mild (Clinical Dementia Rating Scale (CDR) 0.5), or mild (CDR 1) AD, together with their caregivers from three Finnish hospital districts. QoL was evaluated using patient self-reported, and caregiver-rated, QoL in AD (QoL-AD) scores...
January 9, 2017: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28059789/the-mild-behavioral-impairment-checklist%C3%A2-mbi-c-a-rating-scale-for%C3%A2-neuropsychiatric-symptoms-in%C3%A2-pre-dementia-populations
#16
Zahinoor Ismail, Luis Agüera-Ortiz, Henry Brodaty, Alicja Cieslak, Jeffrey Cummings, Corinne E Fischer, Serge Gauthier, Yonas E Geda, Nathan Herrmann, Jamila Kanji, Krista L Lanctôt, David S Miller, Moyra E Mortby, Chiadi U Onyike, Paul B Rosenberg, Eric E Smith, Gwenn S Smith, David L Sultzer, Constantine Lyketsos
BACKGROUND: Mild behavioral impairment (MBI) is a construct that describes the emergence at ≥50 years of age of sustained and impactful neuropsychiatric symptoms (NPS), as a precursor to cognitive decline and dementia. MBI describes NPS of any severity, which are not captured by traditional psychiatric nosology, persist for at least 6 months, and occur in advance of or in concert with mild cognitive impairment. While the detection and description of MBI has been operationalized in the International Society to Advance Alzheimer's Research and Treatment - Alzheimer's Association (ISTAART-AA) research diagnostic criteria, there is no instrument that accurately reflects MBI as described...
December 3, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28039311/sleep-characteristics-and-cognitive-impairment-in-the-general-population-the-hypnolaus-study
#17
José Haba-Rubio, Helena Marti-Soler, Nadia Tobback, Daniela Andries, Pedro Marques-Vidal, Gérard Waeber, Peter Vollenweider, Armin von Gunten, Martin Preisig, Enrique Castelao, Mehdi Tafti, Raphaël Heinzer, Julius Popp
OBJECTIVE: To assess the association between sleep structure and cognitive impairment in the general population. METHODS: Data stemmed from 580 participants aged >65 years of the population-based CoLaus/PsyCoLaus study (Lausanne, Switzerland) who underwent complete sleep evaluation (HypnoLaus). Evaluations included demographic characteristics, personal and treatment history, sleep complaints and habits (using validated questionnaires), and a complete polysomnography at home...
December 30, 2016: Neurology
https://www.readbyqxmd.com/read/28034977/which-facial-descriptors-do-care-home-nurses-use-to-infer-whether-a-person-with-dementia-is-in-pain
#18
Stefan Lautenbacher, Elizabeth L Sampson, Sonja Pähl, Miriam Kunz
OBJECTIVES : Pain assessment in people with advanced dementia relies strongly on observable pain behaviors, such as facial expressions, body movement, and vocalizations. However, the process of inferring pain in others based on such observations is not well understood. We aimed to investigate which features of facial expressions caregivers rely on when inferring the presence and intensity of pain in people with dementia. METHODS : A questionnaire, including items on 13 facial descriptors, which were extracted from established observational scales for pain in dementia, was sent to 366 nursing homes in Germany...
December 29, 2016: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28034964/predictors-and-clinical-impact-of-incident-lacunes-in-cerebral-autosomal-dominant-arteriopathy-with-subcortical-infarcts-and-leukoencephalopathy
#19
Yifeng Ling, François De Guio, Marco Duering, Eric Jouvent, Dominique Hervé, Ophélia Godin, Martin Dichgans, Hugues Chabriat
BACKGROUND AND PURPOSE: Previous studies in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy showed that accumulation of lacunes strongly relate to clinical severity. However, the potential predictors of incident lacunes and their clinical consequences over a short time frame have not been investigated. This study aimed to determine the predictors and clinical impact of such lesions in a large cohort of patients. METHODS: Two hundred and six NOTCH3 mutation carriers (mean age, 49...
December 29, 2016: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28033471/identifiable-characteristics-and-potentially-malleable-beliefs-predict-stigmatizing-attributions-toward-persons-with-alzheimer-s-disease-dementia-results-of-a-survey-of-the-u-s-general-public
#20
Shana D Stites, Rebecca Johnson, Kristin Harkins, Pamela Sankar, Dawei Xie, Jason Karlawish
The general public's views can influence whether people with Alzheimer's disease (AD) experience stigma. The purpose of this study was to understand what characteristics in the general public are associated with stigmatizing attributions. A random sample of adults from the general population read a vignette about a man with mild Alzheimer's disease dementia and completed a modified Family Stigma in Alzheimer's Disease Scale (FS-ADS). Multivariable ordered logistic regressions were used to examine relationships between personal characteristics and FS-ADS ratings...
December 29, 2016: Health Communication
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