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Dementia severity rating scale

Marcela Moreira Lima Nogueira, Jose Pedro Simões Neto, Maria Fernanda B Sousa, Raquel L Santos, Isabel Barbeito Lacerda, Maria Alice Tourinho Baptista, Marcia Cristina Nascimento Dourado
INTRODUCTION: The onset of Alzheimer's disease (AD) affects couples' relationship. We investigated the perception of change and sexual satisfaction in spouse-caregivers and their partners diagnosed with AD. METHODS: We compared 74 dyads of people with Alzheimer's disease (PwAD)/spouse-caregivers and 21 elderly dyads control. We assessed sexual satisfaction with Questionnaire on Sexual Experience and Satisfaction (QSES), cognition using a Mini-Mental State Examination (MMSE), disease severity using a Clinical Dementia Rating scale (CDR), awareness of disease with Assessment Scale of Psychosocial Impact of the Diagnosis of Dementia (ASPIDD), functionality with Pfeffer Functional Activities Questionnaire (FAQ), depressive symptoms with Cornell Scale for Depression in Dementia (CSDD), quality of life using a Quality of Life in Alzheimer's Disease Scale (QoL-AD), and burden using a Zarit Burden Interview (ZBI)...
October 10, 2016: International Psychogeriatrics
Tanya E Davison, Marita P McCabe, Michael Bird, David Mellor, Sarah MacPherson, David Hallford, Melissa Seedy, Daniel W O'Connor
The current study aimed to profile behaviors associated with dementia that pose management difficulties for staff and determine whether existing rating scales capture these reported behaviors. Staff in 17 nursing homes described the behavioral symptoms of 229 residents with predominantly moderate-severe dementia associated with management difficulties. Behaviors were categorized by an expert clinical panel and compared to items in four dementia behavior rating scales. Staff reported 59 discrete behavioral symptoms, with physically agitated, aggressive verbal, non-aggressive verbal, and aggressive physical behaviors most common, followed by resistance to care and inappropriate social and sexual behaviors...
October 5, 2016: Journal of Gerontological Nursing
André Hajek, Christian Brettschneider, Dagmar Lühmann, Marion Eisele, Silke Mamone, Birgitt Wiese, Siegfried Weyerer, Jochen Werle, Michael Pentzek, Angela Fuchs, Steffi G Riedel-Heller, Tobias Luck, Horst Bickel, Dagmar Weeg, Alexander Koppara, Michael Wagner, Martin Scherer, Wolfgang Maier, Hans-Helmut König
OBJECTIVES: To examine how visual impairment affects physical and cognitive function in old age. DESIGN: A longitudinal population-based prospective cohort study. SETTING: General practitioner offices at six study centers in Germany. They were observed every 1.5 years over four waves. PARTICIPANTS: Individuals aged 77-101 at follow-up Wave 2 (N = 2,394). MEASUREMENTS: Physical and cognitive function were assessed using an adapted scale that had been previously developed, and visual impairment was rated on a Likert scale (none, mild, severe or profound)...
September 27, 2016: Journal of the American Geriatrics Society
Mario Tombini, Maura Sicari, Giovanni Pellegrino, Francesca Ursini, Pasqualina Insardá, Vincenzo Di Lazzaro
BACKGROUND: Malnutrition is one of the most important conditions that negatively affects the health of elder people, particularly in patients with dementia. OBJECTIVE: To provide an assessment of nutritional status of patients affected by Alzheimer's disease (AD) living at home and of their caregivers by means of Mini Nutritional Assessment (MNA), and to explore the influence of different factors on nutrition. METHODS: 90 patients affected by AD living at home and 90 age- and sex-matched caregivers were enrolled...
September 12, 2016: Journal of Alzheimer's Disease: JAD
Clarissa M Giebel, David Challis
OBJECTIVE: The Mini-Mental State Examination (MMSE) is one of the most frequently used cognitive measures for dementia severity and linked to deficits in everyday functioning. Recently, the Montreal Cognitive Assessment (MoCA) and the Addenbrooke's Cognitive Examination III (ACE-III) increasingly substitute for the MMSE. However, there are no specific cutoffs in the ACE-III for mild dementia. The objectives of this exploratory study were to assess the sensitivity of each scale to everyday functioning and to examine the cutoffs between mild and moderate dementia on the ACE-III...
September 5, 2016: International Journal of Geriatric Psychiatry
Bo-Lin Ho, Yi-Hui Kao, Mei-Chuan Chou, Yuan-Han Yang
BACKGROUND: Rivastigmine has been approved in the treatment of Alzheimer's disease (AD) patients as it can inhibit acetyl- and butyryl-cholinesterase and provide neuroprotective effects involving the synapses. White matter changes (WMCs) are frequently observed in AD, and clinical-pathological correlations imply their possible impacts on cognitive function by interference with cortical and subcortical neuronal pathways. OBJECTIVE: To evaluate the therapeutic effects of rivastigmine in AD patients with cerebral WMCs...
August 10, 2016: Journal of Alzheimer's Disease: JAD
Akira Midorikawa, Cristian E Leyton, David Foxe, Ramon Landin-Romero, John R Hodges, Olivier Piguet
BACKGROUND: Anecdotal evidence indicates that some patients with dementia exhibit novel or increased positive behaviors, such as painting or singing, after the disease onset. Due to the lack of objective measures, however, the frequency and nature of these changes has not been formally investigated. OBJECTIVE: This study aimed to systematically identify changes in these behaviors in the two most common younger-onset dementia syndromes: Alzheimer's disease (AD) and behavioral-variant frontotemporal dementia (bvFTD)...
September 6, 2016: Journal of Alzheimer's Disease: JAD
Pantelis Maiovis, Panagiotis Ioannidis, Georgios Gerasimou, Anna Gotzamani-Psarrakou, Dimitrios Karacostas
Severity assessment scales for frontotemporal lobar degeneration (FTLD) have been recently introduced. In the present study, the authors examined whether the FTLD-modified Clinical Dementia Rating (FTLD-CDR) scale and the Frontotemporal Dementia Rating Scale (FRS) correlated with regional brain perfusion in Greek FTLD patients. A total of 47 behavioral variant frontotemporal dementia (bvFTD) patients and 33 primary progressive aphasia (PPA) patients were assessed for demographic data, cognitive reserve (CR), and severity of dementia and underwent brain single-photon emission computed tomography...
July 15, 2016: Journal of Neuropsychiatry and Clinical Neurosciences
David Crosiers, Aline Verstraeten, Eline Wauters, Sebastiaan Engelborghs, Karin Peeters, Maria Mattheijssens, Peter P De Deyn, Jessie Theuns, Christine Van Broeckhoven, Patrick Cras
OBJECTIVE: To investigate the frequency of glucocerebrosidase (GBA) mutations in a Flanders-Belgian Parkinson's disease (PD) patient cohort and to assess genotype-phenotype correlations. METHODS: We performed an in-depth sequencing of all coding exons of GBA in 266 clinically well-characterized PD patients and 536 healthy control individuals. RESULTS: We identified rare, heterozygous GBA mutations in 12 PD patients (4.5%) and in 2 healthy control individuals (0...
August 26, 2016: Neuroscience Letters
Gülsen Babacan-Yıldız, Emel Ur-Özçelik, Mehmet Kolukısa, Ahmet Turan Işık, Esra Gürsoy, Gülşen Kocaman, Arif Çelebi
OBJECTIVE: To investigate the validity and reliability of modified Mini Mental State Examination (MMSE-E) for illiterate patients in a Turkish population with Alzheimer's disease (AD). METHOD: A total of 107 illiterate patients with Alzheimer's Disease (women: 65, men: 42) and 68 illiterate healthy volunteer subjects (women: 36, men: 32) were included in the study. MMSE-I and Geriatrics Depression Scale were performed on all subjects, Alzheimer patients were also administered Basic Activities of Daily Living (B- ADL)...
2016: Türk Psikiyatri Dergisi, Turkish Journal of Psychiatry
Yasushi Moriyama, Aihide Yoshino, Taro Muramatsu, Masaru Mimura
AIM: The supermarket task, which is included in the Japanese version of the Rapid Dementia Screening Test, requires the quick (1 min) generation of words for things that can be bought in a supermarket. Cluster size and switches are investigated during this task. We investigated how the severity of dementia related to cluster size and switches on the supermarket task in patients with Alzheimer's disease. METHODS: We administered the Japanese version of the Rapid Dementia Screening Test to 250 patients with very mild to severe Alzheimer's disease and to 49 healthy volunteers...
June 30, 2016: Psychogeriatrics: the Official Journal of the Japanese Psychogeriatric Society
Pan Li, Wei Quan, Yu-Ying Zhou, Yan Wang, Hui-Hong Zhang, Shuai Liu
Previous studies have focused on the curative effects of memantine in patients with mild-to-moderate frontotemporal lobar degeneration (FTLD); however, its benefits in patients with moderate-to-severe FTLD have not been investigated. The present study explores the behavioral, cognitive and functional effects of memantine on behavioral variant frontotemporal dementia (bvFTD) in patients with mild and moderate-to-severe stage bvFTD. A total of 42 patients with bvFTD completed a 6-month treatment plan of 20 mg memantine daily in an open-label, self-controlled clinical trial...
July 2016: Experimental and Therapeutic Medicine
Alessandro Morandi, Jin H Han, David Meagher, Eduard Vasilevskis, Joaquim Cerejeira, Wolfgang Hasemann, Alasdair M J MacLullich, Giorgio Annoni, Marco Trabucchi, Giuseppe Bellelli
OBJECTIVES: Delirium disproportionately affects patients with dementia and is associated with adverse outcomes. The diagnosis of delirium superimposed on dementia (DSD), however, can be challenging due to several factors, including the absence of caregivers or the severity of preexisting cognitive impairment. Altered level of consciousness has been advocated as a possible useful indicator of delirium in this population. Here we evaluated the performance of the Richmond Agitation and Sedation Scale (RASS) and the modified-RASS (m-RASS), an ultra-brief measure of the level of consciousness, in the diagnosis of DSD...
September 1, 2016: Journal of the American Medical Directors Association
Claudia Woolf, Melissa J Slavin, Brian Draper, Floortje Thomassen, Nicole A Kochan, Simone Reppermund, John D Crawford, Julian N Trollor, Henry Brodaty, Perminder S Sachdev
BACKGROUND: The Clinical Dementia Rating Scale (CDR) is used to rate dementia severity. Its utility in diagnosing mild cognitive impairment (MCI) and its predictive value remain unknown. AIMS: The aim of this study was to examine the association between CDR scores and expert MCI diagnosis, and to determine whether baseline CDR scores were predictive of cognitive or functional decline and progression to dementia over 6 years. METHODS: At baseline, the sample comprised 733 non-demented participants aged 70-90 years from the longitudinal Sydney Memory and Ageing Study...
2016: Dementia and Geriatric Cognitive Disorders
Reidun K Sandvik, Geir Selbaek, Sverre Bergh, Dag Aarsland, Bettina S Husebo
OBJECTIVES: To investigate whether it is possible to determine signs of imminent dying and change in pain and symptom intensity during pharmacological treatment in nursing home patients, from day perceived as dying and to day of death. DESIGN: Prospective, longitudinal trajectory trial. SETTING: Forty-seven nursing homes within 35 municipalities of Norway. PARTICIPANTS: A total of 691 nursing home patients were followed during the first year after admission and 152 were assessed carefully in their last days of life...
September 1, 2016: Journal of the American Medical Directors Association
Eirini Kelaiditi, Marco Canevelli, Sandrine Andrieu, Natalia Del Campo, Maria E Soto, Bruno Vellas, Matteo Cesari
OBJECTIVES: To determine whether the Frailty Index (FI) was associated with short-term cognitive decline (according to changes in Mini Mental State Examination (MMSE) and Alzheimer's Disease Assessment Scale-Cognitive subscale (ADAS-Cog) scores at 1-year follow-up) in individuals with Alzheimer's disease (AD). DESIGN: Prospective cohort study. SETTING: Impact of Cholinergic Treatment USe study. PARTICIPANTS: Individuals with mild-to-moderate AD (N = 973)...
June 2016: Journal of the American Geriatrics Society
Yu Chen, Chunxue Wang, Huazheng Liang, Hongyan Chen, Yanchao Bi, Haixin Sun, Qingli Shi, Yongmei Deng, Jia Li, Yongjun Wang, Yumei Zhang
OBJECTIVES: The aim of the study was to investigate the difference of resting-state default-mode network (DMN) between patients with leukoaraiosis (LA)-associated subcortical vascular cognitive impairment (SVCI) and control subjects, and to provide functional imaging evidence of SVCI. METHODS: All subjects (n = 58) were divided into two groups based on their clinical diagnosis: a LA-associated SVCI group (n = 31, 14 males) and a control group (n = 27, 14 males)...
June 2016: Neurological Research
Flora M Hammond, David N Alexander, Andrew J Cutler, Stephen D'Amico, Rachelle S Doody, William Sauve, Richard D Zorowitz, Charles S Davis, Paul Shin, Fred Ledon, Charles Yonan, Andrea E Formella, Joao Siffert
BACKGROUND: Phase 3 trials supporting dextromethorphan/quinidine (DM/Q) use as a treatment for pseudobulbar affect (PBA) were conducted in patients with amyotrophic lateral sclerosis (ALS) or multiple sclerosis (MS). The PRISM II study provides additional DM/Q experience with PBA secondary to dementia, stroke, or traumatic brain injury (TBI). METHODS: Participants in this open-label, multicenter, 90-day trial received DM/Q 20/10 mg twice daily. The primary outcome was the Center for Neurologic Study-Lability Scale (CNS-LS), assessing change in PBA episode frequency and severity...
2016: BMC Neurology
Dawn M Schiehser, J Vincent Filoteo, Irene Litvan, Eva Pirogovsky-Turk, Stephanie L Lessig, David S Song
OBJECTIVE: To examine longitudinal changes in cognition in individuals with Parkinson's disease (PD) with and without a history of traumatic brain injury (TBI). METHODS: Twenty-five PD participants with a history of mild-moderate post-acute (>9 months) TBI and 25 demographically-matched PD controls without a history of TBI were administered measures of cognition (Mattis Dementia Rating Scale), mood, and motor functioning at baseline and at a two-year follow-up evaluation...
September 2016: Parkinsonism & related Disorders
Samanta Lalic, Kris M Jamsen, Barbara C Wimmer, Edwin C K Tan, Sarah N Hilmer, Leonie Robson, Tina Emery, J Simon Bell
PURPOSE: The purpose of this study is to investigate the association between polypharmacy with health-related quality of life (HRQoL) and medication regimen complexity with HRQoL in residential aged care facilities (RACFs). METHODS: A cross-sectional study of 383 residents from six Australian RACFs was conducted. The primary exposures were polypharmacy (≥9 regular medications) and the validated Medication Regimen Complexity Index (MRCI). The outcome measure was staff informant rated quality of life assessed using the Quality of Life Alzheimer's disease (QoL-AD) scale...
September 2016: European Journal of Clinical Pharmacology
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