keyword
https://read.qxmd.com/read/38506985/participant-evaluation-of-a-multi-disciplinary-oncology-preceptorship-training-program-for-oncology-health-professionals-from-kumasi-ghana
#1
JOURNAL ARTICLE
Kenneth W Merrell, Thomas Okpoti Konney, Osei Acheamfour, Joseph Lucido, Abena Yeboah Aduse-Poku, Amanika Kumar, Mavis Bobie Ansah, Adu Tutu Amankwa, Dean Shumway, Fred Kwame Awittor, Augustina Badu-Peprah, Lionel Aurelien A Kankeu Fonkoua, Andrea E Wahner Hendrickson, Ernest Boakye, Ernest Kwasi Adjei, Ishmael Kyei, Katie Kemper, Miranda Rank, Prema P Peethambaram, Kathryn Spangenberg, Kasie Sorenson, Miranda Hearrold, Allison Garda, Rondell Graham, Karen Lang, Joseph Adom, Rita Achiaa, James Jakub, Bismark Dwobeng Amo, Ernest Osei-Bonsu, Rolando Camacho, Eric Clement Desmond Kotei Addison
A critical shortage of skilled healthcare workers is a primary cause of disparate global cancer outcomes. We report participant evaluation of a multidisciplinary preceptorship program. In collaboration with the city of Kumasi, Ghana, Mayo Clinic and the City Cancer Challenge hosted a preceptorship program for comprehensive multidisciplinary breast and cervix cancer training. A total of 14 healthcare workers from Kumasi received two weeks of training at Mayo Clinic in November and December 2021. Each participant and preceptor were requested to complete an anonymous post-participation survey...
March 20, 2024: Journal of Cancer Education: the Official Journal of the American Association for Cancer Education
https://read.qxmd.com/read/38244956/strategies-for-secondary-use-of-real-world-clinical-and-administrative-data-for-outcome-ascertainment-in-pragmatic-clinical-trials
#2
JOURNAL ARTICLE
Cynthia Hau, Patricia A Woods, Amanda S Guski, Srihari I Raju, Liang Zhu, Patrick R Alba, William C Cushman, Peter A Glassman, Areef Ishani, Addison A Taylor, Ryan E Ferguson, Sarah M Leatherman
BACKGROUND: Pragmatic trials are gaining popularity as a cost-effective way to examine treatment effectiveness and generate timely comparative evidence. Incorporating supplementary real-world data is recommended for robust outcome monitoring. However, detailed operational guidelines are needed to inform effective use and integration of heterogeneous databases. OBJECTIVE: Lessons learned from the Veterans Affairs (VA) Diuretic Comparison Project (DCP) are reviewed, providing adaptable recommendations to capture clinical outcomes from real-world data...
January 18, 2024: Journal of Biomedical Informatics
https://read.qxmd.com/read/38221850/-case-report-of-a-14-year-old-girl-with-addison-s-disease-under-initial-presumptive-diagnosis-of-anorexia-nervosa-confusingly-similar-and-yet-so-different
#3
JOURNAL ARTICLE
Linda M Bonnekoh, Ruth Fellmeth, Angelika Dübbers, Sandra Oesingmann-Weirich, Judith Fernholz, Heymut Omran, Georg Romer
Case Report of a 14-Year-Old Girl with Addison's Disease Under Initial Presumptive Diagnosis of Anorexia Nervosa: Confusingly Similar and Yet so Different? Abstract: Objective: Primary adrenal insufficiency (Addison's disease) is a rare differential diagnosis of anorexia nervosa. This case report presents important differential diagnostic aspects. Methods: We prepared a case report of a 14-year-old female patient according to the CARE guidelines, taking the patient's and the child's parents' view into consideration...
January 15, 2024: Zeitschrift Für Kinder- und Jugendpsychiatrie und Psychotherapie
https://read.qxmd.com/read/38059993/dermatologic-surgeons-approaches-to-acral-lentiginous-melanoma-a-survey-of-the-american-college-of-mohs-surgery
#4
JOURNAL ARTICLE
Nasro A Isaq, Addison M Demer, Nahid Y Vidal, Mary E Lohman
Acral lentiginous melanoma (ALM) is a subtype of melanoma that primarily affects ethnic minorities and is associated with poor outcomes. Racial inequalities in melanoma survival, particularly between Blacks and Whites, have been well documented in the literature. There are limited data on the role of surgical approach to ALM and its contribution to the existing disparities in ALM survival. Thus, this study aimed to investigate the role of surgical approach to ALM among Mohs surgeons. The survey was distributed to members of the American College of Mohs Surgery (ACMS), with 43 physicians completing the survey...
December 7, 2023: Archives of Dermatological Research
https://read.qxmd.com/read/37953609/the-risk-vs-benefit-calculus-of-anticoagulation-in-patients-with-ibrutinib-related-atrial-fibrillation
#5
JOURNAL ARTICLE
Ruchi Patel, Arushi Singh, Zhiying Meng, Abigail S Baldridge, Daniel Addison, Nausheen Akhter
For ibrutinib-related atrial fibrillation (IRAF), guidelines for anticoagulation do not exist. We sought to describe stroke, bleeding, and anticoagulation rates among patients with IRAF. We performed a single-center retrospective review of 168 patients treated with ibrutinib followed from 2013 to 2022. Over a median follow-up of 6.4 years, 44 (26.0%) patients developed IRAF of which 38 (86.4%) had a CHA2DS2-VASc ≥2 and 7 (15.9%) had a HAS-BLED ≥3. Anticoagulation was initiated in 20 (45...
November 13, 2023: Leukemia & Lymphoma
https://read.qxmd.com/read/37918821/on-primary-adrenal-insufficiency-with-normal-concentrations-of-cortisol-early-manifestation-of-addison-s-disease
#6
JOURNAL ARTICLE
Hanna Wäscher, Andreas Knauerhase, Bettina Klar, Till Postrach, Marc-André Weber, Holger Sven Willenberg
Primary adrenal insufficiency (AI) is an endocrine disorder in which hormones of the adrenal cortex are produced to an insufficient extent. Since receptors for adrenal steroids have a wide distribution, initial symptoms may be nonspecific. In particular, the lack of glucocorticoids can quickly lead to a life-threatening adrenal crisis. Therefore, current guidelines suggest applying a low threshold for testing and to rule out AI not before serum cortisol concentrations are higher than 500 nmol/l (18 μg/dl)...
November 2, 2023: Hormone and Metabolic Research
https://read.qxmd.com/read/37870730/association-between-race-cardiology-care-and-the-receipt-of-guideline-directed-medical-therapy-in-peripartum-cardiomyopathy
#7
JOURNAL ARTICLE
Ikeoluwapo Kendra Bolakale-Rufai, Shannon M Knapp, Amber E Johnson, LaPrincess Brewer, Selma Mohammed, Daniel Addison, Sula Mazimba, Brownsyne Tucker-Edmonds, Khadijah Breathett
BACKGROUND: Black patients with peripartum cardiomyopathy (PPCM) have disproportionately worse outcomes than White patients, possibly related to variable involvement of cardiovascular specialists in their clinical care. We sought to determine whether race was associated with cardiology involvement in clinical care during inpatient admission and whether cardiology involvement in care was associated with higher claims of guideline-directed medical therapy (GDMT) a week after hospital discharge...
October 23, 2023: Journal of Racial and Ethnic Health Disparities
https://read.qxmd.com/read/37847274/orthostatic-hypotension-hypertension-treatment-and-cardiovascular-disease-an-individual-participant-meta-analysis
#8
COMPARATIVE STUDY
Stephen P Juraschek, Jiun-Ruey Hu, Jennifer L Cluett, Anthony M Ishak, Carol Mita, Lewis A Lipsitz, Lawrence J Appel, Nigel S Beckett, Ruth L Coleman, William C Cushman, Barry R Davis, Greg Grandits, Rury R Holman, Edgar R Miller, Ruth Peters, Jan A Staessen, Addison A Taylor, Lutgarde Thijs, Jackson T Wright, Kenneth J Mukamal
IMPORTANCE: There are ongoing concerns about the benefits of intensive vs standard blood pressure (BP) treatment among adults with orthostatic hypotension or standing hypotension. OBJECTIVE: To determine the effect of a lower BP treatment goal or active therapy vs a standard BP treatment goal or placebo on cardiovascular disease (CVD) or all-cause mortality in strata of baseline orthostatic hypotension or baseline standing hypotension. DATA SOURCES: Individual participant data meta-analysis based on a systematic review of MEDLINE, EMBASE, and CENTRAL databases through May 13, 2022...
October 17, 2023: JAMA
https://read.qxmd.com/read/37758506/autoimmune-disease-in-turner-syndrome-in-sweden-an-up-to-25-years%C3%A2-controlled-follow-up-study
#9
JOURNAL ARTICLE
Sabine Naessén, Malin Eliasson, Kerstin Berntorp, Margareta Kitlinski, Penelope Trimpou, Emily Amundson, Sofia Thunström, Bertil Ekman, Jeanette Wahlberg, Anders Karlsson, Magnus Isaksson, Ingrid Bergström, Carina Levelind, Inger Bryman, Kerstin Landin-Wilhelmsen
CONTEXT: Turner syndrome (TS) is the most common chromosomal aberration in women; it is the result of structural or numeric abnormalities in the X chromosome. Autoimmune hypothyroidism has been recognized as one of the more prominent disorders associated with TS. OBJECTIVE: To study the prevalence of autoimmune diseases in TS. DESIGN AND SETTING: A cross sectional, longitudinal, 25-year follow-up study of patients from adult Turner Centers at the University Hospitals, Sweden...
September 27, 2023: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/37702618/alternative-dolutegravir-dosing-strategies-with-concurrent-rifapentine-utilized-for-latent-tuberculosis-treatment
#10
JOURNAL ARTICLE
Addison Taylor, Elizabeth Winthrop, Patricia Pecora Fulco
We present a case of a 53-year-old person living with human immunodeficiency virus and a new diagnosis of latent tuberculosis. The patient had baseline suppressed HIV viral load on fixed dose combination dolutegravir/abacavir/lamivudine when once-weekly rifapentine 900 mg/isoniazid 900 mg/pyridoxine 25 mg was initiated for 12 weeks. An additional 50 mg dolutegravir dose, administered in the evenings, was added to the daily antiretroviral regimen for treatment duration secondary to rifapentine uridine diphosphate glucuronsyl transferase induction...
December 2023: International Journal of STD & AIDS
https://read.qxmd.com/read/37680621/development-and-external-validation-of-a-mixed-effects-deep-learning-model-to-diagnose-covid-19-from-ct-imaging
#11
JOURNAL ARTICLE
Joshua Bridge, Yanda Meng, Wenyue Zhu, Thomas Fitzmaurice, Caroline McCann, Cliff Addison, Manhui Wang, Cristin Merritt, Stu Franks, Maria Mackey, Steve Messenger, Renrong Sun, Yitian Zhao, Yalin Zheng
BACKGROUND: The automatic analysis of medical images has the potential improve diagnostic accuracy while reducing the strain on clinicians. Current methods analyzing 3D-like imaging data, such as computerized tomography imaging, often treat each image slice as individual slices. This may not be able to appropriately model the relationship between slices. METHODS: Our proposed method utilizes a mixed-effects model within the deep learning framework to model the relationship between slices...
2023: Frontiers in Medicine
https://read.qxmd.com/read/37546049/management-of-adrenal-deficiency-and-shock-in-a-patient-with-polyglandular-autoimmune-syndrome-type-ii
#12
Rebekah Lantz, Waseem Naboulsi, Sarah Yu, Maher Al-Samkari
Polyglandular autoimmune syndrome (PAS) is a rare disorder characterized by the autoimmune destruction of multiple endocrine glands. Type II PAS is the most common of the PAS subtypes and is characterized by Addison's disease, autoimmune thyroid disease, and type I diabetes mellitus. Disease manifestations are predominantly seen in young adulthood with an emerging endocrine disorder; however, a host of other autoimmune conditions can also be present before endocrine organ dysfunction. Due to the complex nature of presentation and management, an important consideration in patient care involves a multidisciplinary team with the addition of an endocrinologist...
July 2023: Curēus
https://read.qxmd.com/read/36893918/spine-patient-care-with-wearable-medical-technology-state-of-the-art-opportunities-and-challenges-a-systematic-review
#13
REVIEW
Ram Haddas, Mark Lawlor, Ehsan Moghadam, Andrew Fields, Addison Wood
BACKGROUND CONTEXT: Healthcare reforms that demand quantitative outcomes and technical innovations have emphasized the use of Disability and Functional Outcome Measurements (DFOMs) to spinal conditions and interventions. Virtual healthcare has become increasingly important following the COVID-19 pandemic, and wearable medical devices have proven to be a useful adjunct. Thus, given the advancement of wearable technology, broad adoption of commercial devices (i.e. smartwatches, phone applications, and wearable monitors) by the general public, and the growing demand from consumers to take control of their health, the medical industry is now primed to formally incorporate evidence-based wearable device-mediated telehealth into standards of care...
March 7, 2023: Spine Journal: Official Journal of the North American Spine Society
https://read.qxmd.com/read/36728060/local-recurrence-rates-of-malignant-melanoma-after-mohs-micrographic-surgery-are-lowest-with-5-to-10-mm-initial-margins-a-systematic-review-and-meta-analysis
#14
JOURNAL ARTICLE
Elliott H Campbell, Olivia M Crum, Cynthia J Chelf, Addison M Demer, Jerry D Brewer
BACKGROUND: Current consensus guidelines have discouraged the use of sub-0.5-cm (in situ) and sub-1-cm (invasive) margins when performing Mohs micrographic surgery (Mohs) for melanoma, with minimal evidence to guide this recommendation. OBJECTIVE: To compare melanoma local recurrence rates after Mohs based on initial margin size. MATERIALS AND METHODS: A systematic review and meta-analysis was conducted with search terms including Mohs micrographic surgery, surgical margin, recurrent disease, and melanoma...
February 1, 2023: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://read.qxmd.com/read/36727874/local-recurrence-rates-of-malignant-melanoma-after-mohs-micrographic-surgery-are-lowest-with-5-to-10-mm-initial-margins-a-systematic-review-and-meta-analysis
#15
JOURNAL ARTICLE
Elliott H Campbell, Olivia M Crum, Cynthia J Chelf, Addison M Demer, Jerry D Brewer
BACKGROUND: Current consensus guidelines have discouraged the use of sub-0.5-cm (in situ) and sub-1-cm (invasive) margins when performing Mohs micrographic surgery (Mohs) for melanoma, with minimal evidence to guide this recommendation. OBJECTIVE: To compare melanoma local recurrence rates after Mohs based on initial margin size. MATERIALS AND METHODS: A systematic review and meta-analysis was conducted with search terms including Mohs micrographic surgery, surgical margin, recurrent disease, and melanoma...
January 19, 2023: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://read.qxmd.com/read/36724537/extensor-mechanism-reconstruction-for-chronic-patellar-tendon-tears
#16
JOURNAL ARTICLE
Addison Cimino, Kevin C Wall, Joseph Elphingstone, Kyle Paul, Alexandra M Arguello, Aaron Casp, Eugene Brabston, Brent Ponce, Amit Momaya
OBJECTIVES: Reconstruction for a chronic patellar tendon rupture in a native knee is an uncommon surgical procedure. Although there have been case series investigating patient-reported outcomes, there is no systematic review of these studies to date. The purpose of this review is to synthesize the literature on this procedure to better understand its outcomes, complications, and surgical technique options. METHODS: A systematic review was performed following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines to identify studies that reported outcomes and techniques of patellar tendon reconstruction for chronic disruption in native knees...
February 2023: Southern Medical Journal
https://read.qxmd.com/read/36650009/pornography-use-among-adolescents-and-the-role-of-primary-care
#17
JOURNAL ARTICLE
Grace B Jhe, Jessica Addison, Jessica Lin, Emily Pluhar
Given the increase in pornography use among adolescents over the years, we discuss the impact of its use on sexual health development as well as the role of primary care providers (PCPs) in assessing use and providing sexual health education. While pornography use is often viewed negatively, it is important to develop unbiased understanding of the use in order to provide non-judgemental, adolescent-focused and educational care. As PCPs are often the first point of contact when adolescents experience medical and behavioural health concerns, it is essential for them to be equipped to screen for pornography use effectively, create a confidential and comfortable environment to talk about pornography use and sexuality, and be informed of ways to promote open discussion between youth and parents...
January 2023: Family Medicine and Community Health
https://read.qxmd.com/read/36526353/seasonality-of-month-of-birth-in-patients-with-autoimmune-endocrine-diseases-a-systematic-review
#18
JOURNAL ARTICLE
Ana M Ramos-Leví, Gloria Collado, Monica Marazuela
BACKGROUND: Exposure to seasonal environmental factors during gestation or early in the postnatal period could influence the development of autoimmunity, determining a seasonality in the month of birth (MOB). There are studies evaluating this potential seasonality in patients with type 1 diabetes (T1D), autoimmune thyroid diseases (AITD), and Addison's disease (ADD), but results have been controversial. METHODS: Systematic review according to PRISMA guidelines, using PubMed, Web of Science and WorldCat databases (2005-2020) of studies that explored the association between the seasonality of the MOB and T1D, AITD and ADD...
December 2022: Endocrinología, diabetes y nutrición
https://read.qxmd.com/read/36483642/pediatric-fractures-following-implant-removal-a-systematic-review
#19
REVIEW
Anthony M Padgett, Cole M Howie, Thomas C Sanchez, Addison Cimino, Kevin A Williams, Shawn R Gilbert, Michael J Conklin
OBJECTIVES: To evaluate the available literature for postoperative fracture rates following implant removal in the pediatric population. METHODS: A systematic review of articles in the PubMed and Embase computerized literature databases from January 2000 to June 2022 was performed using PRISMA guidelines. Randomized controlled trials, case-control studies, cohort studies (retrospective and prospective), and case series involving pediatric patients that included data on fracture rate following removal of orthopedic implants were eligible for review...
December 2022: Journal of Children's Orthopaedics
https://read.qxmd.com/read/36394218/praziquantel-efficacy-urinary-and-intestinal-schistosomiasis-reinfection-a-systematic-review
#20
JOURNAL ARTICLE
Isaac Frimpong Aboagye, Yvonne Abena Afadua Addison
Praziquantel (PZQ) has been extensively used as the drug of choice for the treatment of schistosomiasis on account of its safety and effectiveness against all major forms of schistosomiasis. However, low cure rate, reduced susceptibility of Schistosoma mansoni to PZQ and treatment failures in S . haematobium infections have been reported, raising concerns about its efficacy. Using the search terms, 'praziquantel efficacy, schistosomiasis, school children, reinfection' as well as defined inclusion criteria, and guided by the PRISMA guidelines, articles from 2001 to 2022 were selected from the PubMed and Google Scholar databases and reviewed to assess their importance to the research question...
November 17, 2022: Pathogens and Global Health
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