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Kristen M Wilding, Addison K Smith, Joshua W Wilkerson, Derek B Bush, Thomas Allen Knotts, Bradley Charles Bundy
Although polyethylene glycol (PEG) is commonly used to improve protein stability and therapeutic efficacy, the optimal location for attaching PEG onto proteins is not well understood. Here, we present a cell-free protein synthesis-based screening platform which facilitates site-specific PEGylation and efficient evaluation of PEG attachment efficiency, thermal stability, and activity for different variants of PEGylated T4 lysozyme, including a di-PEGylated variant. We also report developing a computationally-efficient coarse-grain simulation model as a potential tool to narrow experimental screening candidates...
January 2, 2018: ACS Synthetic Biology
J Daniels, J M Turner-Cobb
Consideration of psychological distress in long-term endocrine conditions is of vital importance given the prevalence of anxiety and depression in such disorders. Poor mental health can lead to compromised self-care, higher utilization of health services, lower rates of adherence, reduced quality of life and ultimately poorer outcomes. Adjuvant psychological therapy offers an effective resource to reduce distress in endocrine conditions. While the vast majority of work in this area has focused on psychological screening and intervention in diabetes, identification and recognition of psychological distress are equally important in other endocrinological conditions, with supportive evidence in polycystic ovary syndrome and Addison's disease...
June 2017: Clinical Endocrinology
Azadeh Peyman, Darren Addison, Terry Mee, Cristian Goiceanu, Myron Maslanyj, Simon Mann
Laboratory measurements of electric fields have been carried out around examples of smart meter devices used in Great Britain. The aim was to quantify exposure of people to radiofrequency signals emitted from smart meter devices operating at 2.4 GHz, and then to compare this with international (ICNIRP) health-related guidelines and with exposures from other telecommunication sources such as mobile phones and Wi-Fi devices. The angular distribution of the electric fields from a sample of 39 smart meter devices was measured in a controlled laboratory environment...
May 2017: Bioelectromagnetics
Ravi V Shah, Aferdita Spahillari, Stanford Mwasongwe, J Jeffrey Carr, James G Terry, Robert J Mentz, Daniel Addison, Udo Hoffmann, Jared Reis, Jane E Freedman, Joao A C Lima, Adolfo Correa, Venkatesh L Murthy
Importance: Modern prevention guidelines substantially increase the number of individuals who are eligible for treatment with statins. Efforts to refine statin eligibility via coronary calcification have been studied in white populations but not, to our knowledge, in large African American populations. Objective: To compare the relative accuracy of US Preventive Services Task Force (USPSTF) and American College of Cardiology/American Heart Association (ACC/AHA) recommendations in identifying African American individuals with subclinical and clinical atherosclerotic cardiovascular disease (ASCVD)...
June 1, 2017: JAMA Cardiology
Ravi S Hira, Jennifer B Cowart, Julia M Akeroyd, David J Ramsey, Yashashwi Pokharel, Vijay Nambi, Hani Jneid, Anita Deswal, Ali Denktas, Addison Taylor, Khurram Nasir, Christie M Ballantyne, Laura A Petersen, Salim S Virani
Cardiovascular disease (CVD) is a systemic process involving multiple vascular beds and includes coronary heart disease (CHD), ischemic cerebrovascular disease (ICVD), and peripheral arterial disease (PAD). All these manifestations are associated with an increased risk of subsequent myocardial infarction, stroke, and death. Guideline-directed medical therapy is recommended for all patients with CVD. In a cohort of US veterans, we identified 1,242,015 patients with CVD receiving care in 130 Veterans Affairs facilities from October 1, 2013 to September 30, 2014...
October 15, 2016: American Journal of Cardiology
Jan-Christoph Galle, Janet Addison, Michael G Suranyi, Kathleen Claes, Salvatore Di Giulio, Alain Guerin, Hans Herlitz, István Kiss, Mourad Farouk, Nick Manamley, Gerhard Wirnsberger, Christopher Winearls
BACKGROUND: Extended dosing of the erythropoiesis-stimulating agent (ESA) darbepoetin alfa (DA) once biweekly or monthly reduces anaemia treatment burden. This observational study assessed outcomes and dosing patterns in patients with chronic kidney disease not on dialysis (CKD-NoD) commencing extended dosing of DA. METHODS: Adult CKD-NoD patients starting extended dosing of DA in Europe or Australia in June 2006 or later were followed up until December 2012. Outcomes included haemoglobin (Hb) concentration, ESA dosing, mortality rates and receipt of dialysis and renal transplantation...
December 2016: Nephrology, Dialysis, Transplantation
Brian Hutton, Christina Addison, Sasha Mazzarello, Anil A Joy, Nathaniel Bouganim, Dean Fergusson, Mark Clemons
OBJECTIVE: Questions remain regarding the optimal use of bone-targeted agents in patients with metastatic bone disease. The purpose of this study was to assess current clinical practice regarding the use and administration of bone-targeted agents by Canadian oncologists in patients with metastatic breast and prostate cancer. METHODS: A survey was designed to explore; bone-targeted agent use in metastatic bone disease, variability in the choice and the frequency of administration of these agents...
June 2013: Journal of Bone Oncology
Iryna Kuchuk, Sasha Mazzarello, Kevin Butterfield, Anthony Appleton, Christina L Addison, Mark Clemons
BACKGROUND: Bone-targeted agents such as bisphosphonates and the RANKL antibody have revolutionised the care of patients with bone metastases. There has, however been increasing concern about the oral health of these patients and in particular osteonecrosis of the jaw (ONJ), especially with the increasing use of these agents at higher potencies for greater periods of time. METHODS: A review of the published data in PubMed and meeting abstracts was performed to examine incidence, risk factors, pathogenesis, clinical course and management of osteonecrosis of the jaw with focus on cancer patients treated with bone-targeted agents (BTA) for bone metastases...
February 2013: Journal of Bone Oncology
Vu Hoang, Mahboob Alam, Daniel Addison, Francisco Macedo, Salim Virani, Yochai Birnbaum
PURPOSE: Current practice guidelines support the use of angiotensin-converting enzyme inhibitors (ACEi) and angiotensin-receptor blockers (ARBs) in patients with coronary artery disease (CAD) without heart failure (HF). However, a number of cited trials were performed prior to the era of prevalent statin use. Our objective was to evaluate the effectiveness of ACEi and ARBs in reducing cardiovascular events as well as the impact of statin therapy. METHODS: We searched the MEDLINE and EMBASE databases for randomized-controlled trials (1/1/1980 - 8/31/2015) with ACEi or ARBs as the single intervention for patients with CAD without HF...
April 2016: Cardiovascular Drugs and Therapy
Sally Benton, Robert Steele, Richard Logan, Natasha Djedovic, Steve Smith, Caroline Addison
No abstract text is available yet for this article.
January 2016: Annals of Clinical Biochemistry
Steven A Kahn, Sarah A Davis, Caroline T Banes, Bradley M Dennis, Addison K May, Oliver D Gunter
BACKGROUND: Teaching hospitals often employ advanced practice providers (nurse practitioners and physician assistants or APPs) to counteract residents' work-hour restrictions. With increased utilization of APPs in labor-intense areas, such as intensive care units (ICUs), APPs may have an impact on resident education and experience. No studies have investigated the direct role an APP plays on the training experience of a surgical resident in the ICU. MATERIALS AND METHODS: An institutional review board-approved survey was emailed to residents in Accreditation Council for Graduate Medical Education-accredited general surgery programs...
November 2015: Journal of Surgical Research
Mark Jean Just, Mariusz Kozakiewicz
BACKGROUND: Anemia is a disease that can co-exist with depression, other mental disorders, or somatic diseases. Anemia can imitate symptoms of depression, while depression symptoms can mask concurring symptoms of anemia. CASE PRESENTATION: I am presenting a case of a 48-year-old woman with Addison-Biermer anemia, with co-existing mood disorders. The clinical analysis of the presented patient's history indicates diagnostic problems and a need for a detailed analysis of drug-related complications that occurred during previous treatment, eg, in the form of neuroleptic malignant syndrome...
2015: Neuropsychiatric Disease and Treatment
Eugene Mutimura, Diane Addison, Kathryn Anastos, Donald Hoover, Jean Claude Dusingize, Ben Karenzie, Isabelle Izimukwiye, Leo Mutesa, Sabin Nsanzimana, Denis Nash
BACKGROUND: Initiation of antiretroviral therapy (ART) in the advanced stages of HIV infection remains a major challenge in sub-Saharan Africa. This study was conducted to better understand barriers and enablers to timely ART initiation in Rwanda where ART coverage is high and national ART eligibility guidelines first expanded in 2007-2008. METHODS: Using data on 6326 patients (≥15 years) at five Rwandan clinics, we assessed trends and correlates of CD4 cell count at ART initiation and the proportion initiating ART with advanced HIV disease (CD4 <200 cells/μl or WHO stage IV)...
January 2, 2015: AIDS
Appiah-Korang Labi, Noah Obeng-Nkrumah, Naa Okaikor Addison, Eric S Donkor, Eric Sampene Donkor
BACKGROUND: Despite the clinical significance of Salmonella infections, surveillance data worldwide remains limited and is more so exemplified by the lack of reports from Africa especially in eastern, central and western Africa. This study reports on Salmonella serotypes as significant causes of blood stream infections (BSI) and multidrug antibiotic resistance at Korle-Bu Teaching Hospital in Accra, Ghana. METHODS: Antibiogram patterns, seasonal variations in disease incidence and predisposing factors for infection with Salmonella serotypes were analyzed retrospectively over a 4-year period from January 2010 to December 2013...
2014: BMC Infectious Diseases
Massimo Sartelli, Mark A Malangoni, Addison K May, Pierluigi Viale, Lillian S Kao, Fausto Catena, Luca Ansaloni, Ernest E Moore, Fred A Moore, Andrew B Peitzman, Raul Coimbra, Ari Leppaniemi, Yoram Kluger, Walter Biffl, Kaoru Koike, Massimo Girardis, Carlos A Ordonez, Mario Tavola, Miguel Cainzos, Salomone Di Saverio, Gustavo P Fraga, Igor Gerych, Michael D Kelly, Korhan Taviloglu, Imtiaz Wani, Sanjay Marwah, Miklosh Bala, Wagih Ghnnam, Nissar Shaikh, Osvaldo Chiara, Mario Paulo Faro, Gerson Alves Pereira, Carlos Augusto Gomes, Federico Coccolini, Cristian Tranà, Davide Corbella, Pietro Brambillasca, Yunfeng Cui, Helmut A Segovia Lohse, Vladimir Khokha, Kenneth Yy Kok, Suk-Kyung Hong, Kuo-Ching Yuan
Skin and soft tissue infections (SSTIs) encompass a variety of pathological conditions ranging from simple superficial infections to severe necrotizing soft tissue infections. Necrotizing soft tissue infections (NSTIs) are potentially life-threatening infections of any layer of the soft tissue compartment associated with widespread necrosis and systemic toxicity. Successful management of NSTIs involves prompt recognition, timely surgical debridement or drainage, resuscitation and appropriate antibiotic therapy...
2014: World Journal of Emergency Surgery: WJES
Eugene Mutimura, Diane Addison, Kathryn Anastos, Donald Hoover, Jean Claude Dusingize, Ben Karenzi, Isabelle Izimukwiye, Leo Mutesa, Sabin Nsanzimana, Denis Nash
BACKGROUND: Initiation of antiretroviral therapy (ART) in the advanced stages of HIV infection remains a major challenge in sub-Saharan Africa. This study was conducted to better understand barriers and enablers to timely ART initiation in Rwanda where ART coverage is high and national ART eligibility guidelines first expanded in 2007-2008. METHODS: Using data on 6326 patients (≥15 years) at five Rwandan clinics, we assessed trends and determinants of CD4 cell count at ART initiation and the proportion initiating ART with advanced HIV disease (CD4 <200 cells/μl or WHO stage IV)...
November 13, 2014: AIDS
Nicolas Kluger, Niina Matikainen, Harri Sintonen, Annamari Ranki, Risto P Roine, Camilla Schalin-Jäntti
OBJECTIVE: Patients with Addison's disease (AD) on conventional replacement therapy have impaired health-related quality of life (HRQoL). It is possible that lower hydrocortisone (HC) doses recommended by current guidelines could restore HRQoL. We compared HRQoL in AD patients treated according to current HC recommendations to that of the age- and gender-standardized general population. SUBJECTS, DESIGN AND MEASUREMENT: We assessed HRQoL in a cross-sectional setting with the 15D instrument in a Finnish AD cohort (n = 107) and compared the results with those of a large sample of general population (n = 5671)...
October 2014: Clinical Endocrinology
John Kells, Charles M Dollbaum
Saliva is an excellent medium for the measurement of the biologically active fraction of steroid hormones in the bloodstream because it is a natural ultrafiltrate of blood, and steroids not bound by carrier proteins in the blood freely diffuse into saliva. The baseline measurement of hormone levels in saliva provides an accurate assessment and can be used to identify or monitor a number of clinical conditions, including climacteric changes in perimenopausal or postmenopausal women, adrenal disorders such as Addison's disease or Cushing's disease, and androgen deficiency in men and women, the age-related decrease of hormones such as testosterone and dehydroepiandrosterone can also be assessed and monitored...
July 2009: International Journal of Pharmaceutical Compounding
John A H Wass, Wiebke Arlt
No abstract text is available yet for this article.
October 9, 2012: BMJ: British Medical Journal
Bertil Ekman, Margareta Bachrach-Lindström, Torbjörn Lindström, Jeanette Wahlberg, Johan Blomgren, Hans J Arnqvist
CONTEXT: Current guidelines on how to divide the daily cortisol substitution dose in patients with primary adrenal insufficiency (PAI) are controversial and mainly based on empirical data. OBJECTIVE: To assess how an equal dose of hydrocortisone (HC) given either four times daily or twice daily influence diurnal profiles of cortisol and ACTH, patient preferences and health-related quality of life (HRQoL). DESIGN: Double blind, crossover. METHODS: Fifteen patients with PAI (six women) were included...
July 2012: Clinical Endocrinology
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