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https://www.readbyqxmd.com/read/27553104/risk-factor-optimization-and-guideline-directed-medical-therapy-in-us-veterans-with-peripheral-arterial-and-ischemic-cerebrovascular-disease-compared-to-veterans-with-coronary-heart-disease
#1
Ravi S Hira, Jennifer B Cowart, Julia M Akeroyd, David J Ramsey, Yashashwi Pokharel, Vijay Nambi, Hani Jneid, Anita Deswal, Ali Denktas, Addison Taylor, Khurram Nasir, Christie M Ballantyne, Laura A Petersen, Salim S Virani
Cardiovascular disease (CVD) is a systemic process involving multiple vascular beds and includes coronary heart disease (CHD), ischemic cerebrovascular disease (ICVD), and peripheral arterial disease (PAD). All these manifestations are associated with an increased risk of subsequent myocardial infarction, stroke, and death. Guideline-directed medical therapy is recommended for all patients with CVD. In a cohort of US veterans, we identified 1,242,015 patients with CVD receiving care in 130 Veterans Affairs facilities from October 1, 2013 to September 30, 2014...
October 15, 2016: American Journal of Cardiology
https://www.readbyqxmd.com/read/27190334/outcomes-in-patients-with-chronic-kidney-disease-not-on-dialysis-receiving-extended-dosing-regimens-of-darbepoetin-alfa-long-term-results-of-the-extend-observational-cohort-study
#2
Jan-Christoph Galle, Janet Addison, Michael G Suranyi, Kathleen Claes, Salvatore Di Giulio, Alain Guerin, Hans Herlitz, István Kiss, Mourad Farouk, Nick Manamley, Gerhard Wirnsberger, Christopher Winearls
BACKGROUND: Extended dosing of the erythropoiesis-stimulating agent (ESA) darbepoetin alfa (DA) once biweekly or monthly reduces anaemia treatment burden. This observational study assessed outcomes and dosing patterns in patients with chronic kidney disease not on dialysis (CKD-NoD) commencing extended dosing of DA. METHODS: Adult CKD-NoD patients starting extended dosing of DA in Europe or Australia in June 2006 or later were followed up until December 2012. Outcomes included haemoglobin (Hb) concentration, ESA dosing, mortality rates and receipt of dialysis and renal transplantation...
April 15, 2016: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/26909274/de-escalated-administration-of-bone-targeted-agents-in-patients-with-breast-and-prostate-cancer-a-survey-of-canadian-oncologists
#3
Brian Hutton, Christina Addison, Sasha Mazzarello, Anil A Joy, Nathaniel Bouganim, Dean Fergusson, Mark Clemons
OBJECTIVE: Questions remain regarding the optimal use of bone-targeted agents in patients with metastatic bone disease. The purpose of this study was to assess current clinical practice regarding the use and administration of bone-targeted agents by Canadian oncologists in patients with metastatic breast and prostate cancer. METHODS: A survey was designed to explore; bone-targeted agent use in metastatic bone disease, variability in the choice and the frequency of administration of these agents...
June 2013: Journal of Bone Oncology
https://www.readbyqxmd.com/read/26909271/oral-care-and-the-use-of-bone-targeted-agents-in-patients-with-metastatic-cancers-a-practical-guide-for-dental-surgeons-and-oncologists
#4
REVIEW
Iryna Kuchuk, Sasha Mazzarello, Kevin Butterfield, Anthony Appleton, Christina L Addison, Mark Clemons
BACKGROUND: Bone-targeted agents such as bisphosphonates and the RANKL antibody have revolutionised the care of patients with bone metastases. There has, however been increasing concern about the oral health of these patients and in particular osteonecrosis of the jaw (ONJ), especially with the increasing use of these agents at higher potencies for greater periods of time. METHODS: A review of the published data in PubMed and meeting abstracts was performed to examine incidence, risk factors, pathogenesis, clinical course and management of osteonecrosis of the jaw with focus on cancer patients treated with bone-targeted agents (BTA) for bone metastases...
February 2013: Journal of Bone Oncology
https://www.readbyqxmd.com/read/26861251/efficacy-of-angiotensin-converting-enzyme-inhibitors-and-angiotensin-receptor-blockers-in-coronary-artery-disease-without-heart-failure-in-the-modern-statin-era-a-meta-analysis-of-randomized-controlled-trials
#5
Vu Hoang, Mahboob Alam, Daniel Addison, Francisco Macedo, Salim Virani, Yochai Birnbaum
PURPOSE: Current practice guidelines support the use of angiotensin-converting enzyme inhibitors (ACEi) and angiotensin-receptor blockers (ARBs) in patients with coronary artery disease (CAD) without heart failure (HF). However, a number of cited trials were performed prior to the era of prevalent statin use. Our objective was to evaluate the effectiveness of ACEi and ARBs in reducing cardiovascular events as well as the impact of statin therapy. METHODS: We searched the MEDLINE and EMBASE databases for randomized-controlled trials (1/1/1980 - 8/31/2015) with ACEi or ARBs as the single intervention for patients with CAD without HF...
April 2016: Cardiovascular Drugs and Therapy
https://www.readbyqxmd.com/read/26438519/nice-referral-guidelines-for-suspected-cancer-colorectal-cancer-and-faecal-occult-blood-testing
#6
EDITORIAL
Sally Benton, Robert Steele, Richard Logan, Natasha Djedovic, Steve Smith, Caroline Addison
No abstract text is available yet for this article.
January 2016: Annals of Clinical Biochemistry
https://www.readbyqxmd.com/read/26173380/impact-of-advanced-practice-providers-nurse-practitioners-and-physician-assistants-on-surgical-residents-critical-care-experience
#7
Steven A Kahn, Sarah A Davis, Caroline T Banes, Bradley M Dennis, Addison K May, Oliver D Gunter
BACKGROUND: Teaching hospitals often employ advanced practice providers (nurse practitioners and physician assistants or APPs) to counteract residents' work-hour restrictions. With increased utilization of APPs in labor-intense areas, such as intensive care units (ICUs), APPs may have an impact on resident education and experience. No studies have investigated the direct role an APP plays on the training experience of a surgical resident in the ICU. MATERIALS AND METHODS: An institutional review board-approved survey was emailed to residents in Accreditation Council for Graduate Medical Education-accredited general surgery programs...
November 2015: Journal of Surgical Research
https://www.readbyqxmd.com/read/25995639/depressive-disorders-co-existing-with-addison-biermer-anemia-case-report
#8
Mark Jean Just, Mariusz Kozakiewicz
BACKGROUND: Anemia is a disease that can co-exist with depression, other mental disorders, or somatic diseases. Anemia can imitate symptoms of depression, while depression symptoms can mask concurring symptoms of anemia. CASE PRESENTATION: I am presenting a case of a 48-year-old woman with Addison-Biermer anemia, with co-existing mood disorders. The clinical analysis of the presented patient's history indicates diagnostic problems and a need for a detailed analysis of drug-related complications that occurred during previous treatment, eg, in the form of neuroleptic malignant syndrome...
2015: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/25562492/trends-in-and-correlates-of-cd4-cell-count-at-antiretroviral-therapy-initiation-after-changes-in-national-art-guidelines-in-rwanda
#9
Eugene Mutimura, Diane Addison, Kathryn Anastos, Donald Hoover, Jean Claude Dusingize, Ben Karenzie, Isabelle Izimukwiye, Leo Mutesa, Sabin Nsanzimana, Denis Nash
BACKGROUND: Initiation of antiretroviral therapy (ART) in the advanced stages of HIV infection remains a major challenge in sub-Saharan Africa. This study was conducted to better understand barriers and enablers to timely ART initiation in Rwanda where ART coverage is high and national ART eligibility guidelines first expanded in 2007-2008. METHODS: Using data on 6326 patients (≥15 years) at five Rwandan clinics, we assessed trends and correlates of CD4 cell count at ART initiation and the proportion initiating ART with advanced HIV disease (CD4 <200 cells/μl or WHO stage IV)...
January 2, 2015: AIDS
https://www.readbyqxmd.com/read/25528352/salmonella-blood-stream-infections-in-a-tertiary-care-setting-in-ghana
#10
Appiah-Korang Labi, Noah Obeng-Nkrumah, Naa Okaikor Addison, Eric S Donkor, Eric Sampene Donkor
BACKGROUND: Despite the clinical significance of Salmonella infections, surveillance data worldwide remains limited and is more so exemplified by the lack of reports from Africa especially in eastern, central and western Africa. This study reports on Salmonella serotypes as significant causes of blood stream infections (BSI) and multidrug antibiotic resistance at Korle-Bu Teaching Hospital in Accra, Ghana. METHODS: Antibiogram patterns, seasonal variations in disease incidence and predisposing factors for infection with Salmonella serotypes were analyzed retrospectively over a 4-year period from January 2010 to December 2013...
2014: BMC Infectious Diseases
https://www.readbyqxmd.com/read/25422671/world-society-of-emergency-surgery-wses-guidelines-for-management-of-skin-and-soft-tissue-infections
#11
REVIEW
Massimo Sartelli, Mark A Malangoni, Addison K May, Pierluigi Viale, Lillian S Kao, Fausto Catena, Luca Ansaloni, Ernest E Moore, Fred A Moore, Andrew B Peitzman, Raul Coimbra, Ari Leppaniemi, Yoram Kluger, Walter Biffl, Kaoru Koike, Massimo Girardis, Carlos A Ordonez, Mario Tavola, Miguel Cainzos, Salomone Di Saverio, Gustavo P Fraga, Igor Gerych, Michael D Kelly, Korhan Taviloglu, Imtiaz Wani, Sanjay Marwah, Miklosh Bala, Wagih Ghnnam, Nissar Shaikh, Osvaldo Chiara, Mario Paulo Faro, Gerson Alves Pereira, Carlos Augusto Gomes, Federico Coccolini, Cristian Tranà, Davide Corbella, Pietro Brambillasca, Yunfeng Cui, Helmut A Segovia Lohse, Vladimir Khokha, Kenneth Yy Kok, Suk-Kyung Hong, Kuo-Ching Yuan
Skin and soft tissue infections (SSTIs) encompass a variety of pathological conditions ranging from simple superficial infections to severe necrotizing soft tissue infections. Necrotizing soft tissue infections (NSTIs) are potentially life-threatening infections of any layer of the soft tissue compartment associated with widespread necrosis and systemic toxicity. Successful management of NSTIs involves prompt recognition, timely surgical debridement or drainage, resuscitation and appropriate antibiotic therapy...
2014: World Journal of Emergency Surgery: WJES
https://www.readbyqxmd.com/read/25396264/trends-in-and-determinants-of-cd4-cell-count-at-antiretroviral-therapy-initiation-after-changes-in-national-art-guidelines-in-rwanda
#12
Eugene Mutimura, Diane Addison, Kathryn Anastos, Donald Hoover, Jean Claude Dusingize, Ben Karenzi, Isabelle Izimukwiye, Leo Mutesa, Sabin Nsanzimana, Denis Nash
BACKGROUND: Initiation of antiretroviral therapy (ART) in the advanced stages of HIV infection remains a major challenge in sub-Saharan Africa. This study was conducted to better understand barriers and enablers to timely ART initiation in Rwanda where ART coverage is high and national ART eligibility guidelines first expanded in 2007-2008. METHODS: Using data on 6326 patients (≥15 years) at five Rwandan clinics, we assessed trends and determinants of CD4 cell count at ART initiation and the proportion initiating ART with advanced HIV disease (CD4 <200 cells/μl or WHO stage IV)...
November 13, 2014: AIDS
https://www.readbyqxmd.com/read/24801591/impaired-health-related-quality-of-life-in-addison-s-disease-impact-of-replacement-therapy-comorbidities-and-socio-economic-factors
#13
Nicolas Kluger, Niina Matikainen, Harri Sintonen, Annamari Ranki, Risto P Roine, Camilla Schalin-Jäntti
OBJECTIVE: Patients with Addison's disease (AD) on conventional replacement therapy have impaired health-related quality of life (HRQoL). It is possible that lower hydrocortisone (HC) doses recommended by current guidelines could restore HRQoL. We compared HRQoL in AD patients treated according to current HC recommendations to that of the age- and gender-standardized general population. SUBJECTS, DESIGN AND MEASUREMENT: We assessed HRQoL in a cross-sectional setting with the 15D instrument in a Finnish AD cohort (n = 107) and compared the results with those of a large sample of general population (n = 5671)...
October 2014: Clinical Endocrinology
https://www.readbyqxmd.com/read/23966517/saliva-tests-part-1-clinical-use-elements-of-testing-and-guidelines-for-posttreatment-interpretation
#14
John Kells, Charles M Dollbaum
Saliva is an excellent medium for the measurement of the biologically active fraction of steroid hormones in the bloodstream because it is a natural ultrafiltrate of blood, and steroids not bound by carrier proteins in the blood freely diffuse into saliva. The baseline measurement of hormone levels in saliva provides an accurate assessment and can be used to identify or monitor a number of clinical conditions, including climacteric changes in perimenopausal or postmenopausal women, adrenal disorders such as Addison's disease or Cushing's disease, and androgen deficiency in men and women, the age-related decrease of hormones such as testosterone and dehydroepiandrosterone can also be assessed and monitored...
July 2009: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/23048013/how-to-avoid-precipitating-an-acute-adrenal-crisis
#15
EDITORIAL
John A H Wass, Wiebke Arlt
No abstract text is available yet for this article.
October 9, 2012: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/22288685/a-randomized-double-blind-crossover-study-comparing-two-and-four-dose-hydrocortisone-regimen-with-regard-to-quality-of-life-cortisol-and-acth-profiles-in-patients-with-primary-adrenal-insufficiency
#16
RANDOMIZED CONTROLLED TRIAL
Bertil Ekman, Margareta Bachrach-Lindström, Torbjörn Lindström, Jeanette Wahlberg, Johan Blomgren, Hans J Arnqvist
CONTEXT: Current guidelines on how to divide the daily cortisol substitution dose in patients with primary adrenal insufficiency (PAI) are controversial and mainly based on empirical data. OBJECTIVE: To assess how an equal dose of hydrocortisone (HC) given either four times daily or twice daily influence diurnal profiles of cortisol and ACTH, patient preferences and health-related quality of life (HRQoL). DESIGN: Double blind, crossover. METHODS: Fifteen patients with PAI (six women) were included...
July 2012: Clinical Endocrinology
https://www.readbyqxmd.com/read/21989337/inflammation-aging-and-adiposity-implications-for-physical-therapists
#17
Odessa Addison, Paul C LaStayo, Leland E Dibble, Robin L Marcus
BACKGROUND: Physical therapists treat older individuals, characterized as both a needy and expanding population. Frailty, a predisability condition with links to chronic inflammatory conditions, is estimated to affect 7% of individuals older than 60 years and 40% of people older than 80 years. Chronic inflammation is one of the most important physiologic correlates of the frailty syndrome and high levels of proinflammatory cytokines, related to both aging and increasing adiposity in older individuals are related to an increased risk of mortality, sarcopenia, reduced muscle strength and decreased mobility...
April 2012: Journal of Geriatric Physical Therapy
https://www.readbyqxmd.com/read/21856328/exposure-to-radio-frequency-electromagnetic-fields-from-wireless-computer-networks-duty-factors-of-wi-fi-devices-operating-in-schools
#18
M Khalid, T Mee, A Peyman, D Addison, C Calderon, M Maslanyj, S Mann
The growing use of wireless local area networks (WLAN) in schools has prompted a study to investigate exposure to the radio frequency (RF) electromagnetic fields from Wi-Fi devices. International guidelines on limiting the adverse health effects of RF, such as those of ICNIRP, allow for time-averaging of exposure. Thus, as Wi-Fi signals consist of intermittent bursts of RF energy, it is important to consider the duty factors of devices in assessing the extent of exposure and compliance with guidelines. Using radio packet capture methods, the duty factor of Wi-Fi devices has been assessed in a sample of 6 primary and secondary schools during classroom lessons...
December 2011: Progress in Biophysics and Molecular Biology
https://www.readbyqxmd.com/read/21767156/skin-and-soft-tissue-infections-the-new-surgical-infection-society-guidelines
#19
REVIEW
Addison K May
BACKGROUND: The Surgical Infection Society Guidelines for the treatment of complicated skin and soft tissue infections (SSTIs) were published in October 2009 in Surgical Infections, and an overview of these guidelines was provided at the Thirtieth Annual Meeting of the Society. A summary of this overview is provided. METHODS: Review of relevant papers related to complicated SSTIs published between 1966 and 2008 with graded recommendations and summations of general epidemiology and recommendations...
June 2011: Surgical Infections
https://www.readbyqxmd.com/read/21402737/characteristics-and-effects-of-nurse-dosing-over-rides-on-computer-based-intensive-insulin-therapy-protocol-performance
#20
Thomas R Campion, Addison K May, Lemuel R Waitman, Asli Ozdas, Nancy M Lorenzi, Cynthia S Gadd
OBJECTIVE: To determine characteristics and effects of nurse dosing over-rides of a clinical decision support system (CDSS) for intensive insulin therapy (IIT) in critical care units. DESIGN: Retrospective analysis of patient database records and ethnographic study of nurses using IIT CDSS. MEASUREMENTS: The authors determined the frequency, direction-greater than recommended (GTR) and less than recommended (LTR)- and magnitude of over-rides, and then compared recommended and over-ride doses' blood glucose (BG) variability and insulin resistance, two measures of IIT CDSS associated with mortality...
May 1, 2011: Journal of the American Medical Informatics Association: JAMIA
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