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echocardiography rheumatoid arthritis

Enrico Vizzardi, Ilaria Cavazzana, Franco Franceschini, Ivano Bonadei, Edoardo Sciatti, Carlo M Lombardi, Angela Tincani, Marco Metra
AIM: Rheumatoid arthritis (RA) shows a high risk for cardiovascular disease, including heart failure. Although TNF-α has been implicated in the pathogenesis of myocardial remodelling, TNF-α inhibition did not show any efficacy in patients with advanced heart failure and should be contraindicated in RA with cardiac complications. We aimed to assess global left ventricular (LV) systolic function using global longitudinal strain (GLS) as a measure of myocardial deformation, in a group of RA patients before and during anti-TNF-α treatment...
2016: Monaldi Archives for Chest Disease, Archivio Monaldi Per le Malattie del Torace
Irandokht Shenavar Masooleh, Habib Zayeni, Asghar Haji-Abbasi, Manouchehr Azarpira, Ali Hadian, Amir Hassankhani, Banafsheh Ghavidel Parsa
BACKGROUND: Cardiovascular disease is one of the extra-articular manifestations of rheumatoid arthritis (RA) that is the most common cause of death in these patients. So we decided to evaluate RA patients in terms of history, clinical examination, electrocardiography, and echocardiography to determine the prevalence of types of cardiac involvements in these patients. METHODS: 100 consecutive patients, diagnosed with RA, referred to rheumatology clinic in Razi referral hospital of Rasht, Iran, were enrolled...
May 2016: Indian Heart Journal
Maha A Al-Mohaissen, Kwan-Leung Chan
Cardiovascular disease is an important extra-articular manifestation of rheumatologic diseases leading to considerable mortality and morbidity. Echocardiography emerges as a useful non-invasive technique for the screening and evaluation of cardiac involvement in these patients. With the technological advancement in echocardiographic techniques, we have gained a greater appreciation of the prevalence and nature of the cardiac involvement in these patients, as detection of subclinical disease is increasingly feasible...
August 2016: Current Cardiology Reports
Jung-Hye Choi, Jeong-Eun Park, Jang-Young Kim, Taeyoung Kang
Rheumatoid arthritis (RA) is frequently associated with various extra-joint complications. Although rare, thromboembolic complications are associated with high morbidity and mortality. We experienced a very rare case of nonbacterial thrombotic endocarditis (NBTE) and subsequent embolic stroke in a patient with RA. A 72-year-old male with a 15-year history of RA suddenly developed neurologic symptoms of vomiting and dizziness. Brain magnetic resonance imaging revealed recently developed multiple cerebellar and cerebral lacunar infarctions...
May 2016: Korean Circulation Journal
G E M Reeves, N Collins, P Hayes, J Knapp, M Squance, H Tran, B Bastian
Pulmonary artery hypertension (PAH) is a disorder of elevated resistance in the pulmonary arterial vessels, reflected by elevation of measured pulmonary artery pressure (PAP), and presenting with breathlessness and, if untreated, progressing to right heart failure and death. The heightened prevalence of PAH in populations with underlying systemic autoimmune conditions, particularly scleroderma and its variants, is well recognised, consistent with the proposed autoimmune contribution to PAH pathogenesis, along with disordered thrombotic, inflammatory, and mitogenic factors...
2016: International Journal of Rheumatology
Giovanni Cioffi, Ombretta Viapiana, Federica Ognibeni, Andrea Dalbeni, Giovanni Orsolini, Silvano Adami, Davide Gatti, Maurizio Fisicaro, Luigi Tarantini, Maurizio Rossini
OBJECTIVES: Ascending aorta has an increased stiffness (AoSI) in rheumatoid arthritis (RA) patients due to their chronic inflammatory status. We assessed prevalence and factors associated with increased AoSI and its prognostic role in a large cohort of RA patients. METHODS: We prospectively analysed 226 RA patients without overt cardiac disease compared with 226 non-RA patients matched for cardiovascular risk factors (non-RA controls). Abnormally high AoSI was diagnosed if AoSI > 6...
May 6, 2016: European Journal of Preventive Cardiology
Atsushi Sugiura, Nobusada Funabashi, Koya Ozawa, Yoshio Kobayashi
PURPOSE: Systemic autoimmune disease (SAD) frequently affects the pericardium, and pathology is characterized by both immunological and inflammatory processes. We hypothesized that these processes simultaneously influence mitral-valve (MV) deterioration and left-ventricular (LV) wall thickening in SAD subjects. METHODS: 101 SAD subjects were selected (76 female; 53±17years; systemic-lupus-erythematosus, 26%; vasculitis, 20%; scleroderma, 14%; polymyositis/dermatomyositis complex, 10%; mixed connective tissue disease, 11% and rheumatoid-arthritis, 2%)...
July 15, 2016: International Journal of Cardiology
Helga Midtbø, Eva Gerdts, Tore K Kvien, Inge C Olsen, Mai Tone Lønnebakken, Einar Skulstad Davidsen, Silvia Rollefstad, Anne Grete Semb
BACKGROUND: The association of hypertension with asymptomatic cardiovascular organ damage in patients with rheumatoid arthritis (RA) has been little studied by echocardiography. METHODS: Echocardiography was done in 134 RA patients and 102 healthy controls. Left ventricular (LV) geometry was considered abnormal if LV mass index or relative wall thickness was increased. LV diastolic dysfunction was considered present if septal early diastolic tissue velocity <8 cm/s...
October 2016: Blood Pressure
Chin-Yu Lin, Chien-Yi Hsu, Po-Hsun Huang
UNLABELLED: A 64-year-old man with rheumatoid arthritis (RA) presented to our emergency department with severe chest tightness and dyspnea. His electrocardiography (ECG) showed multiple premature atrial complexes (PACs) with wide QRS, and transthoracic echocardiography revealed severe hypokinesis of the left ventricle. The patient later developed sudden cardiovascular collapse with presumed fulminant myocarditis and cardiogenic shock. Further investigation showed that coronary angiogram, viral studies and autoimmune vasculitis markers were all negative...
November 2014: Acta Cardiol Sin
Esperanza Naredo, Annamaria Iagnocco
Musculoskeletal ultrasound (MSUS) has become a relevant part of rheumatology practice and research because it substantially allows us to optimize management of rheumatic and musculoskeletal diseases. This non-invasive imaging modality is a valuable point-of-care tool to accurately evaluate intra-articular and periarticular structures involved in a wide range of rheumatic diseases in adults and children. In addition, MSUS is an invaluable bedside aid for guiding accurate and safe musculoskeletal aspirations, injections and biopsies...
January 2016: Clinical and Experimental Rheumatology
A Zoli, S Bosello, G Comerci, N Galiano, A Forni, F Loperfido, G F Ferraccioli
Rheumatoid arthritis (RA) is associated with an increased risk of myocardial infarction and congestive heart failure. In RA patients, elevated NT-proBNP levels have been reported to be a prognostic marker of left ventricular dysfunction. In this study, we evaluated cardiorespiratory functional capacity and NT-proBNP levels before and during cardiopulmonary exercise test in early RA (ERA) patients. Twenty ERA patients and 10 healthy controls were studied by color Doppler echocardiography to evaluate ventricular systolic and diastolic function...
November 19, 2015: Rheumatology International
Kentaro Kakuta, Kaoru Dohi, Yoshiko Sato, Takashi Yamanaka, Masaki Kawamura, Toru Ogura, Shiro Nakamori, Naoki Fujimoto, Eitaro Fujii, Norikazu Yamada, Masaaki Ito
BACKGROUND: Chronic inflammatory disease (CID) is a complex multisystem disease characterized by chronic inflammation, which can lead to coronary microvascular dysfunction (CMD) and can also predispose to coronary artery calcium deposition, even in the absence of obstructive coronary artery disease. METHODS: Twenty-one patients with systemic lupus erythematosus (SLE; mean age, 60 ± 11 years), 21 patients with systemic sclerosis (SSc; mean age, 66 ± 11 years), 32 patients with rheumatoid arthritis (RA; mean age, 65 ± 9 years), and 23 control subjects with comparable traditional risk factors for coronary artery disease (mean age, 65 ± 10 years) were prospectively enrolled in the outpatient clinic...
February 2016: Journal of the American Society of Echocardiography
Yasemin Ozden Ayyildiz, Mustafa Gokhan Vural, Tolga Han Efe, Ahmet Goktug Ertem, Cemal Koseoglu, Mehmet Ayturk, Ekrem Yeter, Göksal Keskin, Ramazan Akdemir
INTRODUCTION: We evaluated the impact of tumor necrosis factor alpha (TNF-α) inhibition on left ventricular torsion (LVtor) in patients with rheumatoid arthritis (RA) using speckle-tracking echocardiography (STE). METHODS: Thirty-eight RA patients without cardiovascular disease and 30 healthy subjects were enrolled in the study. Twenty patients received infliximab, a monoclonal antibody against TNF-α, and 18 patients received increasing doses of prednisolone for 180 days...
September 2015: Hellenic Journal of Cardiology: HJC, Hellēnikē Kardiologikē Epitheōrēsē
Tariq Yousuf, Jason Kramer, Adam Kopiec, Zachary Bulwa, Shuvani Sanyal, Jeffrey Ziffra
Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease primarily involving the joint synovium. RA is a systemic disease which has many known extra-articular manifestations. We present a unique case of a patient with long standing RA who presented with a primary complaint of chest and back pain. Echocardiography revealed borderline normal left ventricular function and a large pericardial effusion with the finding of elevated intrapericardial pressure suspicious for cardiac tamponade. Infectious workup was all found to be negative...
September 2015: Journal of Clinical Medicine Research
Kwi Young Kang, Chan Hong Jeon, Sung Jae Choi, Bo Young Yoon, Chan-Bum Choi, Chang Hoon Lee, Chang-Hee Suh, Choong Won Lee, Chul Soo Cho, Eon Jeong Nam, Eun-Mi Koh, Ho-Youn Kim, Hyo Jin Choi, Hyoun-Ah Kim, Jae-Bum Jun, Jaejoon Lee, Jinseok Kim, Jong Dae Ji, Jun Ki Min, Ki Jo Kim, Kichul Shin, Min Wook So, Seong Ryul Kwon, Seong-Kyu Kim, Seong-Su Nah, Seung-Ki Kwok, Soo-Kon Lee, Sung Won Lee, Sung-Hwan Park, Won Park, Yong-Beom Park, Young Ho Lee, Shin-Seok Lee, Dae Hyun Yoo
OBJECTIVES: Pulmonary arterial hypertension (PAH) is a major cause of mortality in connective tissue disease (CTD). The survival rates and mortality-predictive factors of a nationwide registry of Korean patients with CTD-PH measured by echocardiography were determined. METHODS: Patients with CTD-PH were enrolled between April 2008 and December 2012. Hemodynamic parameters and clinical data (WHO-functional class [FC], organ involvement, laboratory tests and treatment agents) were recorded...
July 27, 2015: International Journal of Rheumatic Diseases
I G Kirillova, D S Novikova, T V Popkova, Yu N Gorbunova, E I Markelova, Yu O Korsakova, A V Volkov, E N Alexandrova, A A Novikov, O A Fomicheva, E L Luchikhina, D E Karateev, E L Nasonov
AIM: To estimate the rate of diastolic dysfunction (DD) of the left and right ventricles (LV and RV) in patients with early rheumatoid arthritis (RA) before using disease-modifying antirheumatic drugs (DMARDs) therapy and to investigate its association with traditional risk factors (TRFs) for cardiovascular diseases (CVD) and inflammatory markers. SUBJECTS AND METHODS: The investigation enrolled 74 patients with a valid diagnosis of RA, including 56 (74%) women (median age, 54 years; disease duration, 7 months); the patients who were seropositive for rheumatoid factor (RF) (87%) and/or anti-cyclic citrullinated peptide (anti-CCP) antibodies (100%) who had not been on DMARDs or glucocorticosteroids...
2015: Terapevticheskiĭ Arkhiv
Erdem Fatma, Koc Bunyamin, Sarikaya Savas, Ucar Mehmet, Yazıcı Selma, Boyraz Ismail, Caglar Sabri, Ozyalvacli Gulzade, Donmez Ibrahim, Yazici Mehmet
BACKGROUND: Epidemiologic data indicates that rheumatoid arthritis is an independent risk factor for cardiovascular disease. Epicardial adipose tissue is a novel cardio-metabolic risk factor. Our aim was to evaluate epicardial fat thickness (EFT) using echocardiography in patients with rheumatoid arthritis compared to healthy control subjects. Secondly, we investigated relationship between epicardial fat thickness and clinical and echocardiographic parameters in patients with rheumatoid arthritis...
June 2015: African Health Sciences
Katarzyna Leszczyńska, Maciej Chojnicki, Ireneusz Haponiuk, Krzysztof Preis, Katarzyna Ciach, Katarzyna Gierat-Haponiuk, Zbigniew Łajkowski
INTRODUCTION: Complete heart block (third-degree atrioventricular block) is a defect of the conduction system of the heart, in which the impulse generated in the sinoatrial node does not propagate to the ventricles, and thus the latter contract independently of the atria. A third-degree atrioventricular block can be either congenital or acquired. In 60-70% of the cases, the congenital heart block results from destruction of the conduction system of the fetal heart by anti-Ro/SSA and anti-La/SSB antibodies present in maternal serum...
May 2015: Ginekologia Polska
Mohammad Al-Ani, Michelle Weber, David Winchester, Matthew Kosboth
A 65-year-old man presented with long-standing rheumatoid arthritis (RA), severe fatigue and mild arthritis of metacarpophalaneal joints. Physical examination revealed S3, II/IV decrescendo diastolic murmur and 2+ LL oedema. Anticyclic citrullinated peptide antibodies were >250 units. Echocardiogram showed an 8 cm pericardial mass with no atrial or ventricular collapse and mild to moderate aortic regurgitation. Cardiac MRI defined the mass as a heterogeneous entity attached to the right, anterior and inferior heart borders, with compression on right cardiac structures and the left ventricle...
2015: BMJ Case Reports
Giovanni Cioffi, Ombretta Viapiana, Federica Ognibeni, Andrea Dalbeni, Davide Gatti, Silvano Adami, Carmine Mazzone, Giorgio Faganello, Andre Di Lenarda, Maurizio Rossini
BACKGROUND: Patients with rheumatoid arthritis (RA) have a high risk for cardiovascular disease due to a chronic inflammatory state, accelerated atherosclerosis, and changes in left ventricular (LV) geometry. These conditions predispose patients to LV systolic dysfunction (LVSD). In this study we assessed whether RA is a condition associated with LVSD, and analyzed the prevalence and factors associated with LVSD in patients with RA. PATIENTS AND METHODS: Echocardiographic and clinical data from 198 patients with RA without presence or history of symptoms of cardiac disease were compared with 198 non-RA controls matched for cardiovascular risk factors...
November 2015: Herz
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