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https://www.readbyqxmd.com/read/29334615/hemodynamic-and-metabolic-responses-to-self-paced-and-ramp-graded-exercise-testing-protocols
#1
Nicholas M Beltz, Fabiano Amorim, Ann L Gibson, Jeffrey M Janot, Len Kravitz, Christine M Mermier, Nathan Cole, Terence A Moriarty, Tony P Nunez, Sam Trigg, Lance Dalleck
PURPOSE: Recent examinations have shown lower maximal oxygen uptake (VO2max) during traditional ramp (RAMP) compared to self-paced (SPV) graded exercise testing (GXT) attributed to differences in cardiac ouput. The current study examined the differences in hemodyamic and metabolic responses between RAMP and SPV during treadmill exercise. METHODS: Sixteen recreationally trained men (23.7±3.0 yrs) completed two separate treadmill GXT protocols. SPV consisted of five 2-min stages (10 min total) of increasing speed clamped by the Borg RPE6-20 scale...
January 15, 2018: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/29334345/arm-crank-ergometry-improves-cardiovascular-disease-risk-factors-and-community-mobility-independent-of-body-composition-in-high-motor-complete-spinal-cord-injury
#2
James J Bresnahan, Gary J Farkas, Jody L Clasey, James W Yates, David R Gater
OBJECTIVE: Evaluate the effect of aerobic exercise using arm crank ergometry (ACE) in high motor complete (ISNCSCI A/B) spinal cord injury (SCI) as primarily related to cardiovascular disease (CVD) risk factors and functional mobility and secondarily to body composition and metabolic profiles. DESIGN: Longitudinal interventional study at an academic medical center. METHODS: Ten previously untrained participants (M8/F2, Age 36.7 y ± 10.1, BMI 24...
January 15, 2018: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/29329555/exercise-during-and-after-neoadjuvant-rectal-cancer-treatment-the-exert-trial-study-protocol-for-a-randomized-controlled-trial
#3
Andria R Morielli, Nawaid Usmani, Normand G Boulé, Diane Severin, Keith Tankel, Tirath Nijjar, Kurian Joseph, Alysa Fairchild, Kerry S Courneya
BACKGROUND: Standard treatment for locally advanced rectal cancer includes 5-6 weeks of neoadjuvant chemoradiotherapy (NACRT) followed by total mesorectal excision 6-8 weeks later. NACRT improves local disease control and surgical outcomes but also causes side effects including fatigue, diarrhea, hand-foot syndrome, and physical deconditioning that may impede quality of life (QoL), treatment completion, treatment response, and long-term prognosis. Interventions to improve treatment outcomes and manage side effects that are safe, tolerable and low-cost are highly desirable...
January 12, 2018: Trials
https://www.readbyqxmd.com/read/29324983/pulsatile-hemodynamics-are-associated-with-exercise-capacity-in-patients-with-exertional-dyspnea-and-preserved-left-ventricular-ejection-fraction
#4
M Broufa, S Wassertheurer, B Hametner, R Zweiker, R K Binder, T Weber
Background: Pulsatile hemodynamics are associated with left ventricular filling pressures and diastolic dysfunction. We investigated their relationship with maximum workload and peak oxygen uptake (peak VO2) in patients with exertional dyspnea and preserved left ventricular ejection fraction (LVEF). Methods: Radial waveforms from tonometry were processed with a transfer function, pulse wave analysis and wave separation analysis, yielding central aortic pressures and measures of forward (amplitude of forward wave-Pf) and reflected waves (Augmentation Index-AIx, Augmentation Pressure-AP, amplitude of backward wave-Pb) and their ratio (Reflection Magnitude-RM)...
January 9, 2018: American Journal of Hypertension
https://www.readbyqxmd.com/read/29321131/efficacy-of-ranolazine-in-patients-with-symptomatic-hypertrophic-cardiomyopathy-the-restyle-hcm-randomized-double-blind-placebo-controlled-study
#5
Iacopo Olivotto, Paolo G Camici, Piera Angelica Merlini, Claudio Rapezzi, Monica Patten, Vicent Climent, Gianfranco Sinagra, Benedetta Tomberli, Francisco Marin, Philipp Ehlermann, Lars S Maier, Alessandra Fornaro, Claudius Jacobshagen, Antonello Ganau, Luciano Moretti, Antonio Hernandez Madrid, Raffaele Coppini, Giorgio Reggiardo, Corrado Poggesi, Francesco Fattirolli, Luiz Belardinelli, Gianfranco Gensini, Alessandro Mugelli
BACKGROUND: The late sodium current inhibitor ranolazine reverses the main electrophysiological and mechanical abnormalities of human hypertrophic cardiomyopathy (HCM) cardiomyocytes in vitro, suggesting potential clinical benefit. We aimed to assess the effect of ranolazine on functional capacity, symptomatic status, diastolic function, and arrhythmias in HCM. METHODS AND RESULTS: In this multicenter, double-blind, phase 2 study, 80 adult patients with nonobstructive HCM (age 53±14 years, 34 women) were randomly assigned to placebo (n=40) or ranolazine 1000 mg bid (n=40) for 5 months...
January 2018: Circulation. Heart Failure
https://www.readbyqxmd.com/read/29320309/isocapnic-buffering-phase-a-useful-indicator-of-exercise-endurance-and-prognosis-in-patients-with-coronary-artery-disease
#6
Yun-Shan Yen, Daniel Chiung Jui Su, Kuo-Shu Yuan, Po-Wei Chen, Julie Chi Chow, Willy Chou
OBJECTIVES: The significance of the isocapnic buffering (IB) phase - the period between the first ventilatory threshold (1stVT) and respiratory compensation point (RCP) - has not been adequately established in patients. This study aimed to determine the clinical significance of the IB phase in coronary artery disease (CAD) patients. METHODS: This retrospective study included data of sixty-two CAD patients after coronary artery bypass graft (CABG) or percutaneous coronary intervention (PCI) performed in a single medical center between 2010-2014...
January 10, 2018: Physician and Sportsmedicine
https://www.readbyqxmd.com/read/29317690/active-terahertz-chiral-metamaterials-based-on-phase-transition-of-vanadium-dioxide-vo2
#7
Shengxiang Wang, Lei Kang, Douglas H Werner
Compared with natural materials, chiral metamaterials have been demonstrated with orders of magnitude stronger chiroptical response, which provides the basis for applications such as ultracompact polarization components and plasmonic-enhanced biosensing. Terahertz chiral metamaterials that allow dynamic polarization control of terahertz waves are of great practical interest, but remain extremely rare. Here, we show that hybrid metamaterials integrated with vanadium dioxide (VO2) exhibiting phase transition can enable dynamically tunable chiroptical responses at terahertz frequencies...
January 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29311671/home-exercise-training-improves-exercise-capacity-in-cirrhosis-patients-role-of-exercise-adherence
#8
Calvin Kruger, Margaret L McNeely, Robert J Bailey, Milad Yavari, Juan G Abraldes, Michelle Carbonneau, Kim Newnham, Vanessa DenHeyer, Mang Ma, Richard Thompson, Ian Paterson, Mark J Haykowsky, Puneeta Tandon
Cirrhosis patients have reduced peak aerobic power (peak VO2) that is associated with reduced survival. Supervised exercise training increases exercise tolerance. The effect of home-based exercise training (HET) in cirrhosis is unknown. The objective was to evaluate the safety and efficacy of 8 weeks of HET on peak VO2, 6-minute walk distance (6MWD), muscle mass, and quality of life in cirrhosis. Random assignment to 8 weeks of HET (moderate to high intensity cycling exercise, 3 days/week) or usual care. Exercise adherence defined as completing ≥80% training sessions...
January 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29308846/validity-of-oxygen-uptake-cut-off-criteria-in-plateau-identification-during-horizontal-treadmill-running
#9
Clare E Marsh
BACKGROUND: When determining achievement of maximal oxygen uptake (VO2max) during treadmill running using speed increments, theVO2 cut-off criteria applied during plateau identification is often not justified, not protocol specific, or not related to actual change in VO2 (ΔVO2) with speed increment, which can influence plateau achievement rates between studies. The purpose of this study was to compare plateau incidence using an individualised plateau criteria approach based on a 'percentage' ΔVO2 compared to using previously established criteria of ΔVO2≤2...
January 4, 2018: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/29307865/real-time-analysis-of-the-heart-rate-variability-during-incremental-exercise-for-the-detection-of-the-ventilatory-threshold
#10
Yasuyuki Shiraishi, Yoshinori Katsumata, Taketaro Sadahiro, Koichiro Azuma, Keitaro Akita, Sarasa Isobe, Fumiaki Yashima, Kazutaka Miyamoto, Takahiko Nishiyama, Yuichi Tamura, Takehiro Kimura, Nobuhiro Nishiyama, Yoshiyasu Aizawa, Keiichi Fukuda, Seiji Takatsuki
BACKGROUND: It has never been possible to immediately evaluate heart rate variability (HRV) during exercise. We aimed to visualize the real-time changes in the power spectrum of HRV during exercise and to investigate its relationship to the ventilatory threshold (VT). METHODS AND RESULTS: Thirty healthy subjects (29.1±5.7 years of age) and 35 consecutive patients (59.0±13.2 years of age) with myocardial infarctions underwent cardiopulmonary exercise tests with an RAMP protocol ergometer...
January 7, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29282881/the-negative-influence-of-adiposity-extends-to-intraindividual-variability-in-cognitive-control-among-preadolescent-children
#11
Morgan R Chojnacki, Lauren B Raine, Eric S Drollette, Mark R Scudder, Arthur F Kramer, Charles H Hillman, Naiman A Khan
OBJECTIVE: The objective of this study was to investigate the relationship between adiposity and cognition by using mean accuracy, mean reaction time, and intraindividual variability (IIV) among preadolescents. METHODS: Children 7 to 9 years old (N = 233, 133 females) underwent dual-energy x-ray absorptiometry and a maximal oxygen consumption test to assess whole-body adiposity and aerobic fitness relative to fat-free mass (VO2 FF), respectively. Attentional inhibition was assessed by using a modified flanker task...
December 27, 2017: Obesity
https://www.readbyqxmd.com/read/29282259/exercise-response-in-parkinson-s-disease-insights-from-a-cross-sectional-comparison-with-sedentary-controls-and-a-per-protocol-analysis-of-a-randomised-controlled-trial
#12
Foteini Mavrommati, Johnny Collett, Marloes Franssen, Andy Meaney, Claire Sexton, Andrea Dennis-West, Jill F Betts, Hooshang Izadi, Marko Bogdanovic, Martin Tims, Andrew Farmer, Helen Dawes
OBJECTIVES: To investigate the acute and adaptation cardiovascular and metabolic training responses in people with Parkinson's disease (pwP). DESIGN: (1) A cross-sectional study of exercise response of pwP compared with sedentary controls and (2) an interventional study of exercise training in pwP. SETTING: Community leisure facilities. PARTICIPANTS: pwP (n=83) and sedentary controls (n=55). INTERVENTIONS: Study 1 included participants from a two-arm-parallel single-blind phase II randomised controlled trial (RCT), that undertook a baseline maximal incremental exercise test and study 2 included those randomised to the exercise group in the RCT, who completed a 6-month weekly exercise programme (n=37)...
December 26, 2017: BMJ Open
https://www.readbyqxmd.com/read/29279776/adolescent-trajectories-of-aerobic-fitness-and-adiposity-as-markers-of-cardiometabolic-risk-in-adulthood
#13
S A Jackowski, J C Eisenmann, L B Sherar, D A Bailey, A D G Baxter-Jones
Purpose: The aim of this study was to investigate whether adolescent growth trajectories of aerobic fitness and adiposity were associated with mid-adulthood cardiometabolic risk (CMR). Methods: Participants were drawn from the Saskatchewan Growth and Development Study (1963-1973). Adolescent growth trajectories for maximal aerobic capacity (absolute VO2 (AbsVO2)), skinfolds (SF), representing total body (Sum6SF) and central adiposity (TrunkSF), and body mass index (BMI) were determined from 7 to 17 years of age...
2017: Journal of Obesity
https://www.readbyqxmd.com/read/29276855/assessing-differences-in-cardiorespiratory-fitness-with-respect-to-maturity-status-in-highly-trained-youth-soccer-players
#14
Greg Doncaster, John Iga, Viswanath Unnithan
PURPOSE: The purpose of the study was to examine differences in measures of cardiorespiratory fitness and determinants of running economy with respect to maturity status in a group of highly trained youth soccer players. METHODS: A total of 21 highly trained youth soccer players participated in this study. On separate visits, players' peak oxygen uptake (VO2peak), running economy at 3 different speeds [8 km·h-1, 80% gaseous exchange threshold (GET), and 95% GET], and pulmonary oxygen uptake (VO2) kinetics were determined...
December 23, 2017: Pediatric Exercise Science
https://www.readbyqxmd.com/read/29261437/recovery-responses-to-maximal-exercise-in-healthy-weight-children-and-children-with-obesity
#15
Elizabeth A Easley, W Scott Black, Alison L Bailey, Terry A Lennie, Wilma J Sims, Jody L Clasey
PURPOSE: The purpose of this study was to examine differences in heart rate recovery (HRRec) and oxygen consumption recovery (VO2 recovery) between young healthy-weight children and children with obesity following a maximal volitional graded exercise test (GXTmax). METHOD: Twenty healthy-weight children and 13 children with obesity completed body composition testing and performed a GXTmax. Immediately after the GXTmax, HRRec and VO2 recovery were measured each minute for 5 consecutive minutes...
December 20, 2017: Research Quarterly for Exercise and Sport
https://www.readbyqxmd.com/read/29259808/how-is-rating-of-perceived-capacity-related-to-vo2max-and-what-is-vo2max-at-onset-of-training
#16
Christina Gjestvang, Trine Stensrud, Lene A H Haakstad
Objective: To evaluate how rating of perceived capacity (RPC) is related to maximal oxygen uptake (VO2max) and examine VO2max at onset of training in healthy adults. Methods: In total, 125 newly registered fitness centre members, equally men and women, answered the RPC scale and performed a treadmill test for measurement of VO2max. Eligible criteria were <4 weeks of fitness centre membership, physically inactive, ≥18 years and not pregnant. The RPC is a one-page scale (1-20) based on metabolic equivalent tasks, where the individual chooses the most strenuous activity that can be sustained for at least 30 min...
2017: BMJ Open Sport & Exercise Medicine
https://www.readbyqxmd.com/read/29248640/association-of-active-and-passive-components-of-lv-diastolic-filling-with-exercise-intolerance-in-heart-failure-with-preserved-ejection-fraction-mechanistic-insights-from-spironolactone-response
#17
Wojciech Kosmala, Monika Przewlocka-Kosmala, Thomas H Marwick
OBJECTIVES: This study sought to investigate the association of left ventricular (LV) untwisting rate (UT) and E/e' ratio with the response of exercise capacity to spironolactone in heart failure with preserved ejection fraction (HFpEF). BACKGROUND: In most patients with HFpEF, LV filling abnormalities represent a central component in the development of dyspnea. LV diastolic filling is determined by the interplay of passive (LV stiffness and myocardial collagen content, reflected by E/e' ratio) and active myocardial properties (UT, a precursor to isovolumic pressure decay and contributor to diastolic suction)...
December 8, 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29244836/energy-compensation-after-sprint-and-high-intensity-interval-training
#18
Matthew M Schubert, Elyse Palumbo, Rebekah F Seay, Katie K Spain, Holly E Clarke
BACKGROUND: Many individuals lose less weight than expected in response to exercise interventions when considering the increased energy expenditure of exercise (ExEE). This is due to energy compensation in response to ExEE, which may include increases in energy intake (EI) and decreases in non-exercise physical activity (NEPA). We examined the degree of energy compensation in healthy young men and women in response to interval training. METHODS: Data were examined from a prior study in which 24 participants (mean age, BMI, & VO2max = 28 yrs, 27...
2017: PloS One
https://www.readbyqxmd.com/read/29243013/exercise-performance-in-pediatric-liver-transplant-recipients-and-its-related-cardiac-function
#19
Seyed Mohsen Dehghani, Mitra Moshref, Hamid Amoozgar, Seyed Ali Malek Hoseini, Saman Nikeghbalian
The aim of this study was to evaluate an exercise test in pediatric liver transplant recipients and its relation to their cardiac function. This cross-sectional study was conducted on 58 children who had successfully undergone orthotopic liver transplantation at least 6 months prior to the study, with the same age and gender-matched control group. M-mode, Doppler, tissue Doppler echocardiography and an exercise test were performed for all the participants. The VO2 values and METS in patients were less than the control (P = 0...
December 14, 2017: Pediatric Cardiology
https://www.readbyqxmd.com/read/29239983/effects-of-2-dehydration-on-lactate-concentration-during-constant-load-cycling
#20
J M Green, Miller Bl, J D Simpson, Dubroc Dr, Keyes Aa, Neal Kk, Gann Jj, Andre Tl
The lactate [La] threshold can predict endurance performance potential. Dehydration may alter [La] threshold. This study examined effects of dehydration on [La] response during constant load cycling. Recreationally fit (VO2 peak = 48.7 ± 5.2 ml•kg•min) male participants (n=9) completed 2 x 40 min constant-load cycling trials; euhydrated (HYD) and following previous evening passive (water bath) dehydration (2% body weight, DEH) (HYD and DEH counterbalanced). [La], heart rate (HR), 10 point Omni Ratings of Perceived Exertion (RPE) and rectal temperature (Trec) were measured following warm-up and at 10, 20, 30, and 40 min...
December 11, 2017: Journal of Strength and Conditioning Research
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