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https://www.readbyqxmd.com/read/29145494/global-analysis-of-gene-expression-mediated-by-ox1-orexin-receptor-signaling-in-a-hypothalamic-cell-line
#1
Eric Koesema, Thomas Kodadek
The orexins and their cognate G-protein coupled receptors have been widely studied due to their associations with various behaviors and cellular processes. However, the detailed downstream signaling cascades that mediate these effects are not completely understood. We report the generation of a neuronal model cell line that stably expresses the OX1 orexin receptor (OX1) and an RNA-Seq analysis of changes in gene expression seen upon receptor activation. Upon treatment with orexin, several families of related transcription factors are transcriptionally regulated, including the early growth response genes (Egr), the Kruppel-like factors (Klf), and the Nr4a subgroup of nuclear hormone receptors...
2017: PloS One
https://www.readbyqxmd.com/read/29145469/development-of-visual-cortical-function-in-infant-macaques-a-bold-fmri-study
#2
Tom J Van Grootel, Alan Meeson, Matthias H J Munk, Zoe Kourtzi, J Anthony Movshon, Nikos K Logothetis, Lynne Kiorpes
Functional brain development is not well understood. In the visual system, neurophysiological studies in nonhuman primates show quite mature neuronal properties near birth although visual function is itself quite immature and continues to develop over many months or years after birth. Our goal was to assess the relative development of two main visual processing streams, dorsal and ventral, using BOLD fMRI in an attempt to understand the global mechanisms that support the maturation of visual behavior. Seven infant macaque monkeys (Macaca mulatta) were repeatedly scanned, while anesthetized, over an age range of 102 to 1431 days...
2017: PloS One
https://www.readbyqxmd.com/read/29145416/two-is-better-than-one-the-effects-of-strategic-cooperation-on-intra-and-inter-brain-connectivity-by-fnirs
#3
Michela Balconi, Laurent Pezard, Jean-Louis Nandrino, Maria Elide Vanutelli
Inter-brain synchronization during joint actions is a core question in social neuroscience, and the differential contribution of intra- and inter-brain functional connectivity has yet to be clarified along with the role of psychological variables such as perceived self-efficacy. The cognitive performance and the neural activation underlying the execution of joint actions were recorded by functional Near-Infrared imaging during a synchronicity game. An 8-channel array of optodes was positioned over the frontal and prefrontal regions...
2017: PloS One
https://www.readbyqxmd.com/read/29145183/catastrophe-reaction-and-emotionalism
#4
Antonio Carota, Julien Bogousslavsky
The catastrophic reaction (CR; a disruptive and uncontrolled behavior triggered by anger, irritability, and hostility) and emotionalism (a condition of uncontrolled crying or laughing) are disorders of the emotional regulation and expression, the prevalence of which is underestimated in neurology. Their occurrence is an additional factor of poor outcome for neurologic patients. Although they have been recognized and completely described in their clinical manifestations more than a century ago, many issues remain unsolved regarding their pathogenesis and the respective role of the brain damage and psychological factors...
2018: Frontiers of Neurology and Neuroscience
https://www.readbyqxmd.com/read/29145027/differential-gene-expression-in-the-intestine-of-sea-cucumber-apostichopus-japonicus-under-low-and-high-salinity-conditions
#5
Libin Zhang, Qiming Feng, Lina Sun, Kui Ding, Da Huo, Yan Fang, Tao Zhang, Hongsheng Yang
Sea cucumber, Apostichopus japonicus is an important species for aquaculture, and its behavior and physiology can change in response to changing salinity conditions. For this reason, it is important to understand the molecular responses of A. japonicus when exposed to ambient changes in salinity. In this study, RNA-Seq provided a general overview of the gene expression profiles in the intestine of A. japonicus exposed to high salinity (SD40), normal salinity (SD30) and low salinity (SD20) environments. Screening for differentially expressed genes (DEGs) using the NOISeq method identified 109, 100, and 89 DEGs based on a fold change of ≥2 and divergence probability ≥0...
November 4, 2017: Comparative Biochemistry and Physiology. Part D, Genomics & Proteomics
https://www.readbyqxmd.com/read/29145012/the-gut-brain-interaction-in-opioid-tolerance
#6
REVIEW
Hamid I Akbarali, William L Dewey
The prevailing opioid crisis has necessitated the need to understand mechanisms leading to addiction and tolerance, the major contributors to overdose and death and to develop strategies for developing drugs for pain treatment that lack abuse liability and side-effects. Opioids are commonly used for treatment of pain and symptoms of inflammatory bowel disease. The significant effect of opioids in the gut, both acute and chronic, includes persistent constipation and paradoxically may also worsen pain symptoms...
November 13, 2017: Current Opinion in Pharmacology
https://www.readbyqxmd.com/read/29144982/bone-mesenchymal-stem-cell-secretion-of-srankl-opg-m-csf-in-response-to-macrophage-mediated-inflammatory-response-influences-osteogenesis-on-nanostructured-ti-surfaces
#7
Qian-Li Ma, Liang Fang, Nan Jiang, Liang Zhang, Ying Wang, Yu-Mei Zhang, Li-Hua Chen
Although it has been well established that osteogenic differentiation of bone mesenchymal stem cells (bMSCs) as well as osteoclastic differentiation of macrophages can be manipulated by the nanostructure of biomaterial surfaces, the interactions among the effects of the surface on immune cells and bMSCs remained unknown. Therefore, in this study, the osteogenic behaviors and secretion of osteoclastogenesis-related cytokines of human bMSCs on TiO2 nanotubular (NT) surfaces in conditioned medium (CM) generated by macrophages cultured on the respective NT surfaces (NT-CM) were analyzed...
November 4, 2017: Biomaterials
https://www.readbyqxmd.com/read/29144892/preventable-tooth-loss-in-hawai-i-the-role-of-socioeconomic-status-diabetes-and-dental-visits
#8
Mikako Deguchi, Marjorie K Leimomi Mala Mau, James Davis, Richard Niederman
INTRODUCTION: Tooth preservation in adults and children is one of the Healthy People 2020 goals for oral health. Although the overall prevalence of tooth loss has been declining in the United States, substantial racial/ethnic differences in preventable tooth loss persist as a public health problem. We examined the strength of the association of health risk factors and tooth loss in Hawai'i. METHODS: We used data from the Hawai'i Behavioral Risk Factor Surveillance System survey collected from 2011 through 2014...
November 16, 2017: Preventing Chronic Disease
https://www.readbyqxmd.com/read/29144422/atypical-processing-of-novel-distracters-in-a-visual-oddball-task-in-autism-spectrum-disorder
#9
Estate M Sokhadze, Eva V Lamina, Emily L Casanova, Desmond P Kelly, Ioan Opris, Irma Khachidze, Manuel F Casanova
Several studies have shown that children with autism spectrum disorder (ASD) show abnormalities in P3b to targets in standard oddball tasks. The present study employed a three-stimulus visual oddball task with novel distracters that analyzed event-related potentials (ERP) to both target and non-target items at frontal and parietal sites. The task tested the hypothesis that children with autism are abnormally orienting attention to distracters probably due to impaired habituation to novelty. We predicted a lower selectivity in early ERPs to target, frequent non-target, and rare distracters...
November 16, 2017: Behavioral Sciences
https://www.readbyqxmd.com/read/29144282/substrate-effects-in-high-gain-low-operating-voltage-snse2-photoconductor
#10
Krishna Murali, Sangeeth Kallatt, Kausik Majumdar
High gain photoconductive devices find wide spread applications in low intensity light detection. Ultra-thin layered materials have recently attracted a lot of attention from researchers in this regard. However, in general, a large operating voltage is required to obtain large responsivity in these devices. In addition, the characteristics are often confounded by substrate induced trap effects. Here we report multi-layer SnSe2 based photoconductive devices using two different structures: (1) SiO2 substrate supported interdigitated electrode (IDE), and (2) suspended channel...
November 16, 2017: Nanotechnology
https://www.readbyqxmd.com/read/29144200/mechanisms-underlying-melatonin-mediated-prevention-of-fenvalerate-induced-behavioral-and-oxidative-toxicity-in-zebrafish
#11
Jingjing Han, Cheng Ji, Yichen Guo, Rui Yan, Ting Hong, Yuanyan Dou, Yan An, Shasha Tao, Fenju Qin, Jihua Nie, Chen Ji, Han Wang, Jian Tong, Wei Xiao, Jie Zhang
The neurotoxic effects attributed to the pesticide fenvalerate (FEN) are well-established. The aim of this study was to determine whether melatonin (MLT) was able to protect against FEN-induced behavior, oxidative stress, apoptosis, and neurogenesis using zebrafish (Danio rerio) model. Zebrafish exposed to 100 μg/L FEN for 120 h exhibited decreased swimming activity accompanied by downregulated expression of neurogenesis-related genes (Dlx2, Shha, Ngn1, Elavl3, and Gfap), suggesting that neurogenesis were impaired...
November 16, 2017: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/29144147/pursued-for-their-prescription-exposure-to-compliance-gaining-strategies-predicts-stimulant-diversion-in-emerging-adults
#12
Laura J Holt, Paige N Marut, Ty S Schepis
Researchers have begun to identify predictors of who will divert their stimulant prescriptions, as most emerging adults (EAs) who use prescription stimulants nonmedically procure these drugs from a friend or acquaintance with a prescription. Far less research has examined how EAs with attention-deficit/hyperactivity disorder (ADHD) are approached for these medications, and their affective and behavioral responses to these requests. We hypothesized that EAs with a stimulant prescription who reported greater exposure to compliance-gaining attempts from peers, particularly rational appeals for academic work, would be more likely to divert, as would EAs who reported lower resistance to peer influence...
November 16, 2017: Psychology of Addictive Behaviors: Journal of the Society of Psychologists in Addictive Behaviors
https://www.readbyqxmd.com/read/29143523/new-insights-into-electronic-structure-and-photoelectrochemical-property-of-nitrogen-doped-hnb3o8-behaviors-via-a-combined-in-situ-experimental-with-dft-investigation
#13
Xiaobin Liu, Zhenyu Wang, Peng Chen, Huanfu Zhou, Ling Bing Kong, Chunming Niu, Wenxiu Que
Nitrogen-doping approach has been intensively adopted to improve the various properties of metal oxides-especially for adjusting energy band structure and extending photo-response range of oxide photocatalyst. However, nitrogen doped behavior is still unintelligible and complex due to the diversity of the compositions and crystal structures. In this work, new insights into electronic structure and photoelectrochemical property of nitrogen-doping HNb3O8 behaviors were presented. On the one hand, we utilized an in-situ experimental strategy to ascertain the effect of nitrogen-doping on the energy band and photoelectrochemical (PEC) property of HNb3O8 and nitrogen-doped HNb3O8 (N-HNb3O8)...
November 16, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29143414/central-pain-processing-in-drug-na%C3%A3-ve-pain-free-patients-with-parkinson-s-disease
#14
Alessandro Tessitore, Antonio Russo, Rosa De Micco, Michele Fratello, Giuseppina Caiazzo, Alfonso Giordano, Mario Cirillo, Gioacchino Tedeschi, Fabrizio Esposito
BACKGROUND: Despite its clinical relevance, the pathophysiology of pain in Parkinson's disease (PD) is still largely unknown, and both central and peripheral mechanisms have been invoked. OBJECTIVES: To investigate whether central pain processing is altered in "drug-naive" pain-free PD (dnPD) patients. METHODS: Using event-related functional MRI (fMRI), functional response to forearm heat stimulation (FHS) at two different intensities (41°C and 53°C) was investigated in 20 pain-free dnPD patients, compared with 18 healthy controls (HCs)...
November 15, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/29143335/self-perceived-coparenting-of-nonresident-fathers-scale-development-and-validation
#15
W Justin Dyer, Jay Fagan, Rebecca Kaufman, Jessica Pearson, Natasha Cabrera
This study reports on the development and validation of the Fatherhood Research and Practice Network coparenting perceptions scale for nonresident fathers. Although other measures of coparenting have been developed, this is the first measure developed specifically for low-income, nonresident fathers. Focus groups were conducted to determine various aspects of coparenting. Based on this, a scale was created and administered to 542 nonresident fathers. Participants also responded to items used to examine convergent and predictive validity (i...
November 16, 2017: Family Process
https://www.readbyqxmd.com/read/29142907/social-effects-of-health-care-reform-medicaid-expansion-under-the-affordable-care-act-and-changes-in-volunteering
#16
Heeju Sohn, Stefan Timmermans
Do public health policy interventions result in pro-social behaviors? The Affordable Care Act (ACA)'s Medicaid expansions were responsible for the largest gains in public insurance coverage since its inception in 1965. These gains were concentrated in states that opted to expand Medicaid eligibility and provide a unique opportunity to study not just medical but also social consequences of increased public health coverage. This article examines the association between Medicaid and volunteer work. Volunteerism is implicated in individuals' health and well-being yet it is highly correlated with a person's existing socioeconomic resources...
January 2017: Socius
https://www.readbyqxmd.com/read/29142865/osteosarcoma-of-the-jaws-in-koreans-analysis-of-26-cases
#17
Hye-In Jeong, Mi Jee Lee, Woong Nam, In-Ho Cha, Hyung Jun Kim
Objectives: In order to assess clinical behavior, response to treatment, and factors influencing prognosis of Korean patients with osteosarcoma of the jaws (OSJ). Materials and Methods: A retrospective study of clinical, and pathological records of 26 patients with OSJ treated at the Department of Oral and Maxillofacial Surgery in Yonsei University Dental Hospital from 1990 to March 2017. Results: Of 26 patients, there were 9 men (34.6%) and 17 women (65...
October 2017: Journal of the Korean Association of Oral and Maxillofacial Surgeons
https://www.readbyqxmd.com/read/29142795/comorbid-post-traumatic-stress-disorder-and-opioid-dependence
#18
Rikinkumar S Patel, Ahmed Elmaadawi, Suhayl Nasr, John Haskin
Post-traumatic stress disorder (PTSD) is predominant amongst individuals addicted to opioids and obscures the course of illness and the treatment outcome. We report the case of a patient with major depressive disorder and opioid dependence, who experienced post-traumatic stress disorder symptoms during a recent visit to the inpatient unit. The similarity of symptoms between post-traumatic stress disorder and opioid dependence is so high that, sometimes, it is a challenge to differentiate between these conditions...
September 3, 2017: Curēus
https://www.readbyqxmd.com/read/29142226/people-with-higher-interoceptive-sensitivity-are-more-altruistic-but-improving-interoception-does-not-increase-altruism
#19
Richard M Piech, Daniela Strelchuk, Jake Knights, Jonathan V Hjälmheden, Jonas K Olofsson, Jane E Aspell
People consistently show preferences and behaviors that benefit others at a cost to themselves, a phenomenon termed altruism. We investigated if perception of one's body signals - interoception - may be underlying such behaviors. We tested if participants' sensitivity to their own heartbeat predicted their decision on a choice between self-interest and altruism, and if improving this sensitivity through training would make participants more altruistic. Across these two experiments, interoceptive sensitivity predicted altruism measured through monetary generosity...
November 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29141883/thermal-history-and-gape-of-individual-mytilus-californianus-correlate-with-oxidative-damage-and-thermoprotective-osmolytes
#20
Lani U Gleason, Luke P Miller, Jacob R Winnikoff, George N Somero, Paul H Yancey, Dylan Bratz, W Wesley Dowd
The ability of animals to cope with environmental stress depends - in part - on past experience, yet knowledge of the factors influencing an individual's physiology in nature remains underdeveloped. We used an individual monitoring system to record body temperature and valve gaping behavior of rocky intertidal zone mussels (Mytilus californianus). Thirty individuals were selected from two mussel beds (wave-exposed and wave-protected) that differ in thermal regime. Instrumented mussels were deployed at two intertidal heights (near the lower and upper edges of the mussel zone) and in a continuously submerged tidepool...
November 15, 2017: Journal of Experimental Biology
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