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https://www.readbyqxmd.com/read/28822042/implementation-of-a-big-data-accessing-and-processing-platform-for-medical-records-in-cloud
#1
Chao-Tung Yang, Jung-Chun Liu, Shuo-Tsung Chen, Hsin-Wen Lu
Big Data analysis has become a key factor of being innovative and competitive. Along with population growth worldwide and the trend aging of population in developed countries, the rate of the national medical care usage has been increasing. Due to the fact that individual medical data are usually scattered in different institutions and their data formats are varied, to integrate those data that continue increasing is challenging. In order to have scalable load capacity for these data platforms, we must build them in good platform architecture...
August 18, 2017: Journal of Medical Systems
https://www.readbyqxmd.com/read/28821649/effector-invariant-movement-encoding-in-the-human-motor-system
#2
Shlomi Haar, Ilan Dinstein, Ilan Shelef, Opher Donchin
Ipsilateral motor areas of cerebral cortex are active during arm movements and even reliably predict movement direction. Is coding similar during ipsilateral and contralateral movements? If so, is it in extrinsic (world-centered) or intrinsic (joint-configuration) coordinates? We addressed these questions by examining the similarity of multi-voxel fMRI patterns in visuomotor cortical regions during unilateral reaching movements with both arms. The results of three complementary analyses revealed that fMRI response patterns were similar across right and left arm movements to identical targets (extrinsic coordinates) in visual cortices, and across movements with equivalent joint-angles (intrinsic coordinates) in motor cortices...
August 16, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28820598/methylene-blue-location-in-hydroperoxized-cardiolipin-monolayer-implication-in-membrane-photodegradation
#3
Rafael Maglia de Souza, Paulo Siani, Thaís F Schmidt, Rosangela Itri, Luis Gustavo Dias
We present molecular dynamics simulations of Cardiolipin (CL) and of a CL monohydroperoxized derivative (CLOOH) monolayers to investigate the initial steps of phospholipid oxidation induced by methylene blue (MB) photo-excitation under continuous illumination. We considered different MB atomic charge distributions to simulate MB electronic distribution in the singlet ground and triplet excited states. Simulation results allied to experimental data revealed that initial CL photooxidation probably occurs via type II mechanism, to produce lipid hydroperoxide by singlet oxygen attack to the alkyl chain unsaturations...
August 18, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28820239/capping-layer-cl-induced-anti-damping-in-cl-py-%C3%AE-w-system-cl-al-%C3%AE-ta-cu-%C3%AE-w
#4
Nilamani Behera, Puspendu Guha, Dinesh K Pandya, Sujeet Chaudhary
For achieving ultrafast switching speed and minimizing dissipation losses, the spin-based data storage device requires a control on effective damping (αeff) of nanomagnetic bits. Incorporation of interfacial anti-damping spin orbit torque (SOT) in spintronic devices therefore has high prospects in enhancing their performance efficiency. Clear evidence of such an interfacial anti-damping is found in Al capped Py(15 nm)/β-W(tW)/Si (Py=Ni81Fe19 and tW = thickness of β-W), which is in contrast to the increase of αeff (i...
August 18, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28820214/mediated-water-electrolysis-in-biphasic-systems
#5
Micheál D Scanlon, Pekka Peljo, Lucie Rivier, Heron Vrubel, Hubert H Girault
The concept of efficient electrolysis by linking photoelectrochemical biphasic H2 evolution and water oxidation processes in the cathodic and anodic compartments of an H-cell, respectively, is introduced. Overpotentials at the cathode and anode are minimised by incorporating light-driven elements into both biphasic reactions. The concepts viability is demonstrated by electrochemical H2 production from water splitting utilising a polarised water-organic interface in the cathodic compartment of a prototype H-cell...
August 18, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28819973/mobile-platform-for-multiplexed-detection-and-differentiation-of-disease-specific-nucleic-acid-sequences-using-microfluidic-loop-mediated-isothermal-amplification-and-smartphone-detection
#6
Weili Chen, Hojeong Yu, Fu Sun, Akid Ornob, Ryan Brisbin, Anurup Ganguli, Vinay Kumar Vemuri, Piotr Strzebonski, Guangzhe Cui, Karen J Allen, Smit A Desai, Weiran Lin, David M Nash, David Hirschberg, Ian Brooks, Rashid Bashir, Brian T Cunningham
New tools are needed to enable rapid detection, identification, and reporting of infectious viral and microbial pathogens in a wide variety of point-of-care applications that impact human and animal health. We report the design, construction, and characterization of a platform for multiplexed analysis of disease-specific DNA sequences that utilizes a smartphone camera as the sensor in conjunction with a handheld "cradle" that interfaces the phone with a silicon-based microfluidic chip embedded within a credit card-sized cartridge...
August 18, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28819547/continuous-force-decoding-from-deep-brain-local-field-potentials-for-brain-computer-interfacing
#7
Syed A Shah, Huiling Tan, Peter Brown
Current Brain Computer Interface (BCI) systems are limited by relying on neuronal spikes and decoding limited to kinematics only. For a BCI system to be practically useful, it should be able to decode brain information on a continuous basis with low latency. This study investigates if force can be decoded from local field potentials (LFP) recorded with deep brain electrodes located at the Subthalamic nucleus (STN) using data from 5 patients with Parkinson's disease, on a continuous basis with low latency. A Wiener-Cascade (WC) model based decoder was proposed using both time-domain and frequency-domain features...
2017: International IEEE/EMBS Conference on Neural Engineering: [proceedings]
https://www.readbyqxmd.com/read/28819295/tailoring-heterovalent-interface-formation-with-light
#8
Kwangwook Park, Kirstin Alberi
Integrating different semiconductor materials into an epitaxial device structure offers additional degrees of freedom to select for optimal material properties in each layer. However, interfaces between materials with different valences (i.e. III-V, II-VI and IV semiconductors) can be difficult to form with high quality. Using ZnSe/GaAs as a model system, we explore the use of ultraviolet (UV) illumination during heterovalent interface growth by molecular beam epitaxy as a way to modify the interface properties...
August 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28819205/fast-wide-volume-functional-imaging-of-engineered-in-vitro-brain-tissues
#9
G Palazzolo, M Moroni, A Soloperto, G Aletti, G Naldi, M Vassalli, T Nieus, F Difato
The need for in vitro models that mimic the human brain to replace animal testing and allow high-throughput screening has driven scientists to develop new tools that reproduce tissue-like features on a chip. Three-dimensional (3D) in vitro cultures are emerging as an unmatched platform that preserves the complexity of cell-to-cell connections within a tissue, improves cell survival, and boosts neuronal differentiation. In this context, new and flexible imaging approaches are required to monitor the functional states of 3D networks...
August 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28818635/linking-the-tao-biomathics-and-information-through-the-logic-of-energy
#10
REVIEW
Joseph E Brenner
The knowledge accumulated in West and East is incomplete in different ways. The mainstream Western approach has contributed the basis for modern science, but indications have appeared in the Western literature that something has been missing in it that Eastern thought could offer. This paper explores the similarities and differences between Eastern and Western approaches to knowledge and whether a trend exists toward their conjunction or convergence. I suggest that a process of conjunction of these different modes of exploration of what the concepts of 'Life and Mind' really entail, at the interface of philosophy and science, is taking place in the areas of information and biomathics...
August 14, 2017: Progress in Biophysics and Molecular Biology
https://www.readbyqxmd.com/read/28818509/the-use-of-high-flow-nasal-cannula-in-the-pediatric-emergency-department
#11
REVIEW
Katherine N Slain, Steven L Shein, Alexandre T Rotta
OBJECTIVES: To summarize the current literature describing high-flow nasal cannula (HFNC) use in children, the components and mechanisms of action of a HFNC system, the appropriate clinical applications, and its role in the pediatric emergency department (ED). SOURCES: A computer-based search of PubMed/MEDLINE and Google Scholar for literature on HFNC use in children was performed. DATA SUMMARY: HFNC, a non-invasive respiratory support modality, provides heated and fully humidified gas mixtures to patients via a nasal cannula interface...
August 14, 2017: Jornal de Pediatria
https://www.readbyqxmd.com/read/28818344/the-2016-espen-arvid-wretlind-lecture-the-gut-in-stress
#12
REVIEW
Stephen A McClave, Cynthia C Lowen, Robert G Martindale
The gut has a major influence on the course of the human stress response in critical illness for several reasons; the quantity of its immune tissue, the extent of interface with the external environment, the expanse of the microbiome, and its access to the systemic circulation. In critical illness, it is not uncommon to lose mucosal barrier function, which exposes the host to the downside effects of luminal contents and epithelial cell regulation. In that setting, the microbiome is converted to a pathobiome, upregulation of metabolic and immune responses occurs, and homeostatic defense systems are compromised...
July 29, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/28816702/as-above-so-below-towards-understanding-inverse-models-in-bci
#13
Jussi T Lindgren
In Brain-Computer Interfaces (BCI), measurements of the users brain activity are classified into commands for the computer. With EEG-based BCIs, the origins of the classified phenomena are often considered to be spatially localized in the cortical volume and mixed in the EEG. Does the reconstruction of the source activities in the volume help in building more accurate BCIs? The answer remains inconclusive despite previous work. In this paper, we study the question by contrasting the physiology-driven source reconstruction with data-driven representations obtained by statistical machine learning...
August 17, 2017: Journal of Neural Engineering
https://www.readbyqxmd.com/read/28816431/carbon-nanotubes-arranged-as-smart-interfaces-in-lipid-langmuir-blodgett-films-enhancing-the-enzymatic-properties-of-penicillinase-for-biosensing-applications
#14
Fabio Scholl, Paulo Morais, Rayla Gabriel, Michael J Schöning, Jose Roberto Siqueira, Luciano Caseli
In this paper, carbon nanotubes (CNTs) were incorporated in penicillinase-phospholipid Langmuir and Langmuir-Blodgett (LB) films to enhance the enzyme catalytic properties. Adsorption of the penicillinase and CNTs at dimyristoylphosphatidic acid (DMPA) monolayers at the air-water interface was investigated by surface pressure-area isotherms, vibrational spectroscopy and Brewster angle microscopy. The floating monolayers were transferred to solid supports through the LB technique, forming mixed DMPA-CNTs-PEN films, which were investigated by quartz crystal microbalance, vibrational spectroscopy, and atomic force microscopy...
August 17, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28816360/c-c-motif-chemokine-ligand-2-regulates-lps-induced-inflammation-and-er-stress-to-enhance-proliferation-of-bovine-endometrial-epithelial-cells
#15
Whasun Lim, Hyocheol Bae, Fuller W Bazer, Sung-Man Kim, Gwonhwa Song
Chemokines play an important role in regulating the complex immune system at the maternal-fetal interface during pregnancy. Among various chemokines, C-C motif chemokine ligand 2 (CCL2) plays a role in the recruitment of immune regulatory cells to implantation sites within the endometrium. In cattle, CCL2 is abundantly expressed in the uterine endometrium. However, its intracellular signaling has not been identified. In this study, we examined the effects of CCL2 on bovine endometrial (BEND) cell proliferation...
August 17, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28816053/in-vitro-exposure-systems-and-dosimetry-assessment-tools-for-inhaled-tobacco-products-workshop-proceedings-conclusions-and-paths-forward-for-in-vitro-model-use
#16
Holger Behrsing, Erin Hill, Hans Raabe, Raymond Tice, Suzanne Fitzpatrick, Robert Devlin, Kent Pinkerton, Günter Oberdörster, Chris Wright, Roman Wieczorek, Michaela Aufderheide, Sandro Steiner, Tobias Krebs, Bahman Asgharian, Richard Corley, Michael Oldham, Jason Adamson, Xiang Li, Irfan Rahman, Sonia Grego, Pei-Hsuan Chu, Shaun McCullough, Rodger Curren
In 2009, the passing of the Family Smoking Prevention and Tobacco Control Act facilitated the establishment of the FDA Center for Tobacco Products (CTP), and gave it regulatory authority over the marketing, manufacture and distribution of tobacco products, including those termed 'modified risk'. On 4-6 April 2016, the Institute for In Vitro Sciences, Inc. (IIVS) convened a workshop conference entitled, In Vitro Exposure Systems and Dosimetry Assessment Tools for Inhaled Tobacco Products, to bring together stakeholders representing regulatory agencies, academia and industry to address the research priorities articulated by the FDA CTP...
July 2017: Alternatives to Laboratory Animals: ATLA
https://www.readbyqxmd.com/read/28816051/lipid-stabilized-water-oil-interfaces-studied-by-micro-focusing-small-angle-x-ray-scattering
#17
Emanuela Di Cola, Kristian Torbensen, Ilaria Clemente, Federico Rossi, Sandra Ristori, Ali Abou-Hassan
Water in oil (w/o) simple emulsions are dispersed micro-confined systems which find applications in many areas of advanced materials and biotechnology, such as food industry, drug delivery and cosmetics, to name but a few. In these systems, the structural and chemical properties of the boundary layer at the w/o interface are of paramount importance to determine functionality and stability. Recently, microfluidic methods have emerged as a valuable tool to fabricate monodisperse emulsion droplets. Due to the intrinsic flexibility of microfluidics, different interfaces can be obtained, and general principles governing the interfacial stability are needed to guide the experimental approach...
August 17, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28816025/aromatic-interactions-at-the-ligand-protein-interface-implications-for-the-development-of-docking-scoring-functions
#18
Michal Brylinski
The ability to design and fine-tune non-covalent interactions between organic ligands and proteins is indispensable to rational drug development. Aromatic stacking has long been recognized as one of the key constituents of ligand-protein interfaces. In this communication, we employ a two-parameter geometric model to conduct a large-scale statistical analysis of aromatic contacts in the experimental and computer-generated structures of ligand-protein complexes, considering various combinations of aromatic amino acid residues and ligand rings...
August 17, 2017: Chemical Biology & Drug Design
https://www.readbyqxmd.com/read/28815640/in-vitro-genotoxicity-of-airborne-ni-np-in-air-liquid-interface
#19
Siiri Latvala, Daniel Vare, Hanna L Karlsson, Karine Elihn
Studies using advanced toxicological methods enabling in vitro conditions that are more realistic are currently needed for understanding the risks of pulmonary exposure to airborne nanoparticles. Owing to the carcinogenicity of certain nickel compounds, the increased production of nickel nanoparticles (Ni-NPs) raises occupational safety concerns. The aim of this study was to investigate the genotoxicity of airborne Ni-NPs using a recently developed air-liquid interface exposure system. The wild-type Chinese hamster lung fibroblast cell line (V79) was used and cytotoxicity, DNA damage and mutagenicity were studied by testing colony forming efficiency, alkaline DNA unwinding and HPRT mutation assays, respectively...
August 16, 2017: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/28815151/eye-tracking-for-clinical-decision-support-a-method-to-capture-automatically-what-physicians-are-viewing-in-the-emr
#20
Andrew J King, Harry Hochheiser, Shyam Visweswaran, Gilles Clermont, Gregory F Cooper
Eye-tracking is a valuable research tool that is used in laboratory and limited field environments. We take steps toward developing methods that enable widespread adoption of eye-tracking and its real-time application in clinical decision support. Eye-tracking will enhance awareness and enable intelligent views, more precise alerts, and other forms of decision support in the Electronic Medical Record (EMR). We evaluated a low-cost eye-tracking device and found the device's accuracy to be non-inferior to a more expensive device...
2017: AMIA Summits on Translational Science Proceedings
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