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https://www.readbyqxmd.com/read/28214917/mtss1-promotes-maturation-and-maintenance-of-cerebellar-neurons-via-splice-variant-specific-effects
#1
Thorsten Sistig, Fanziska Lang, Sebastian Wrobel, Stephan L Baader, Karl Schilling, Britta Eiberger
Efficient coupling of the actin cytoskeleton to the cell membrane is crucial for histogenesis and maintenance of the nervous system. At this critical interface, BAR (Bin-Amphiphysin-Rvs) proteins regulate membrane bending, shown to be instrumental for mobility and morphogenesis of individual cells. Yet, the systemic significance of these proteins remains largely unexplored. Here, we probe the role of a prominent member of this protein family, the inverse-BAR protein Mtss1, for the development and function of a paradigmatic neuronal circuit, the cerebellar cortex...
February 18, 2017: Brain Structure & Function
https://www.readbyqxmd.com/read/28214102/vitreomacular-adhesion-and-the-risk-of-neovascular-age-related-macular-degeneration
#2
Emilia Maggio, Antonio Polito, Massimo Guerriero, Guido Prigione, Barbara Parolini, Grazia Pertile
PURPOSE: To assess the prevalence of vitreomacular adhesion (VMA) in consecutive naïve eyes diagnosed with exudative age-related macular degeneration (AMD) in comparison with eyes with nonexudative AMD and age-matched controls, and to evaluate prospectively the incidence of vitreomacular interface changes over time and their influence on choroidal neovascularization (CNV) development. DESIGN: Retrospective cross-sectional analysis and longitudinal cohort study conducted at Sacrocuore Hospital, Negrar, Verona, Italy...
February 14, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28213521/signalling-adaptor-shcd-suppresses-erk-phosphorylation-distal-to-the-ret-and-trk-neurotrophic-receptors
#3
Melanie K B Wills, Ava Keyvani Chahi, Hayley R Lau, Manali Tilak, Brianna Guild, Laura A New, Peihua Lu, Keévin Jacquet, Susan O Meakin, Nicolas Bisson, Nina Jones
Proteins of the Shc family are typically involved in signal transduction events involving Ras/MAPK and PI3K/Akt pathways. In the nervous system, they function proximal to the neurotrophic factors that regulate cell survival, differentiation, and neuron-specific characteristics. The least-characterized homolog, ShcD, is robustly expressed in the developing and mature nervous system, but its contributions to neural cell circuitry are largely uncharted. We now report that ShcD binds to active Ret, TrkA, and TrkB neurotrophic factor receptors predominantly via its phosphotyrosine binding (PTB) domain...
February 17, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28213514/peripheral-membrane-interactions-boost-the-engagement-by-an-anti-hiv-1-broadly-neutralizing-antibody
#4
Edurne Rujas, José M M Caaveiro, Sara Insausti, Miguel García-Porras, Kouhei Tsumoto, José L Nieva
The 4E10 antibody displays an extreme breadth of HIV-1 neutralization and therefore constitutes a suitable model system for structure- guided vaccine design and immunotherapeutics against AIDS. In this regard, the relevance of auto- reactivity with membrane lipids for the biological function of this antibody is still a subject of controversy. To address this dispute, herein we have compared the membrane-partitioning ability of the 4E10 antibody and several of its variants, which were mutated at the region of the paratope surface in contact with the membrane-interface...
February 17, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28213151/automatic-method-for-estimation-of-in-situ-effective-contact-angle-from-x-ray-micro-tomography-images-of-two-phase-flow-in-porous-media
#5
Alessio Scanziani, Kamaljit Singh, Martin J Blunt, Alberto Guadagnini
Multiphase flow in porous media is strongly influenced by the wettability of the system, which affects the arrangement of the interfaces of different phases residing in the pores. We present a method for estimating the effective contact angle, which quantifies the wettability and controls the local capillary pressure within the complex pore space of natural rock samples, based on the physical constraint of constant curvature of the interface between two fluids. This algorithm is able to extract a large number of measurements from a single rock core, resulting in a characteristic distribution of effective in situ contact angle for the system, that is modelled as a truncated Gaussian probability density distribution...
February 8, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28213148/interface-tuning-and-stabilization-of-monoglyceride-mesophase-dispersions-food-emulsifiers-and-mixtures-efficiency
#6
Sébastien Serieye, Fabienne Méducin, Irena Milošević, Ling Fu, Samuel Guillot
Several food surfactants were examined as possible efficient emulsifiers for liquid crystalline monolinolein-based particles and as alternative choices to the non-food-grade emulsifier conventionally used Pluronic® F127. We described a food emulsifiers' toolbox, investigating their ability to emulsify mesophases (stabilization capacity, particle size, zeta potential) and their impact on internal nanostructures (from swelling to drastic modifications). Among the selected surfactants, sucrose stearate (S1670) was found to be the best candidate for replacing in a long term F127 as an efficient stabilizer of lipid particles...
January 27, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28213141/thermostability-of-photosystem-i-trimers-and-monomers-from-the-cyanobacterium-thermosynechococcus-elongatus
#7
Vladimir V Shubin, Irina V Terekhova, Yulia V Bolychevtseva, Eithar El-Mohsnawy, Matthias Rögner, Werner Mäntele, Marta J Kopczak, Enela Džafić
The performance of solar energy conversion into alternative energy sources in artificial systems highly depends on the thermostability of photosystem I (PSI) complexes Terasaki et al. (2007), Iwuchukwu et al. (2010), Kothe et al. (2013) . To assess the thermostability of PSI complexes from the thermophilic cyanobacterium Thermosynechococcus elongatus heating induced perturbations on the level of secondary structure of the proteins were studied. Changes were monitored by Fourier transform infrared (FT-IR) spectra in the mid-IR region upon slow heating (1°C per minute) of samples in D2O phosphate buffer (pD 7...
February 6, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28212616/general-practitioners-views-on-long-term-prescription-and-use-of-problematic-and-potentially-inappropriate-medication-for-oldest-old-patients-a-qualitative-interview-study-with-gps-cim-triad-study
#8
Nadine Janis Pohontsch, Kathrin Heser, Antje Löffler, Britta Haenisch, Debora Parker, Tobias Luck, Steffi G Riedel-Heller, Wolfgang Maier, Frank Jessen, Martin Scherer
BACKGROUND: Potentially inappropriate medication (PIM) is defined as medication with uncertain therapeutic effects and/or potential adverse drug reactions outweighing the clinical benefits. The prescription rate of PIM for oldest-old patients is high despite the existence of lists of PIM (e.g. the PRISCUS list) and efforts to raise awareness. This study aims at identifying general practitioners' views on PIM and aspects affecting the (long-term) use of PIM. METHODS: As part of the CIM-TRIAD study, we conducted semi-structured, qualitative interviews with 47 general practitioners, discussing 25 patients with and 22 without PIM (according to the PRISCUS list)...
February 17, 2017: BMC Family Practice
https://www.readbyqxmd.com/read/28212602/happi-2-a-comprehensive-and-high-quality-map-of-human-annotated-and-predicted-protein-interactions
#9
Jake Y Chen, Ragini Pandey, Thanh M Nguyen
BACKGROUND: Human protein-protein interaction (PPI) data is essential to network and systems biology studies. PPI data can help biochemists hypothesize how proteins form complexes by binding to each other, how extracellular signals propagate through post-translational modification of de-activated signaling molecules, and how chemical reactions are coupled by enzymes involved in a complex biological process. Our capability to develop good public database resources for human PPI data has a direct impact on the quality of future research on genome biology and medicine...
February 17, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28212033/surface-induced-changes-in-the-thermochromic-transformation-of-an-ionic-liquid-cobalt-thiocyanate-complex
#10
Benjamin May, Michael Hönle, Bettina Heller, Francesco Greco, Radha Gobinda Bhuin, Hans-Peter Steinrück, Florian Maier
We demonstrate that a thermodynamic complex equilibrium within an ionic liquid film can be significantly influenced by the presence of the liquid-vacuum interface. Using surface sensitive X-ray photoelectron spectroscopy, we find that the temperature-driven transition from the blue-colored tetrahedral [Co(II)(NCS)4](2-) to the red-colored octahedral [Co(II)(NCS)6](4-) complex occurs within the outermost nanometers already around +4 °C as compared to -25 °C in the bulk. This thermochromic transformation in the near-surface region goes along with a loss in preferential surface orientation of free [SCN](-) anions and with a pronounced decrease in the complex density; both effects are attributed to the formation of a weakly-bound solvation shell around the [Co(II)(NCS)6](4-) anion leading to an effective complex dilution...
February 17, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28211795/a-murine-model-of-a-novel-surgical-architecture-for-proprioceptive-muscle-feedback-and-its-potential-application-to-control-of-advanced-limb-prostheses
#11
Tyler R Clites, Matthew Carty, Shriya Srinivasan, Anthony Zorzos, Hugh Herr
<i>Objective:</i> Proprioceptive mechanisms play a critical role in both reflexive and volitional lower extremity control. Significant strides have been made in the development of bionic limbs that are capable of bi-directional communication with the peripheral nervous system, but none of these systems have been capable of providing physiologically-relevant muscle-based proprioceptive feedback through natural neural pathways. In this study, we present the Agonist-antagonist Myoplastic Interface (AMI), a surgical approach with the capacity to provide graded kinesthetic feedback from a prosthesis through mechanical activation of native mechanoreceptors within residual agonist-antagonist muscle pairs...
February 17, 2017: Journal of Neural Engineering
https://www.readbyqxmd.com/read/28211741/enhanced-crystal-growth-in-binary-lennard-jones-mixtures
#12
M Radu, K Kremer
We study the crystal growth in binary Lennard-Jones mixtures by molecular dynamics simulations. Growth dynamics, the structure of the liquid-solid interfaces as well as droplet incorporation into the crystal vary with solution properties. For demixed systems we observe a strongly enhanced crystal growth at the cost of enclosed impurities. Furthermore, we find different interface morphologies depending on solubility. We relate our observations to growth mechanisms based on the Gibbs-Thomson effect as well as to predictions of the Kardar-Parisi-Zhang theory in 2+1 dimensions...
February 3, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28211673/capillary-microfluidics-assembled-virus-like-particle-bio-nano-receptor-interfaces-for-label-free-biosensing
#13
Faheng Zang, Konstantinos Gerasopoulos, Adam D Brown, James N Culver, Reza Ghodssi
In this paper, a capillary microfluidics-integrated sensor system is developed for rapid assembly of bionanoreceptor interfaces on-chip and label-free biosensing. Genetically engineered Tobacco mosaic virus (TMV) virus-like particle (VLP), displaying thousands copies of identical receptor peptides FLAG-tags, are utilized as nanoceptors for antibody sensing. Controlled and accelerated assembly of VLP receptor layer on impedance sensor has been achieved using capillary effect and surface evaporation from an open-channel capillary microfluidic system...
February 17, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28211288/imaging-evaluating-of-the-implant-bone-interface-an-in-vitro-radiographic-study
#14
M M Vidor, G S Liedke, M B Vizzotto, Hld da Silveira, P F da Silveira, C W Araujo, Hed da Silveira
OBJECTIVES: To analyze the diagnostic accuracy of conventional and digital radiographic images and the impact of digital filters in evaluating the bone/implant interface. METHODS: Titanium implants were inserted into 74 fresh bovine ribs blocks, 37 fitting tight to the bone walls (simulating the existence of osseointegration), and 37 with a gap of 0.125 mm (simulating a failure in the osseointegration process). Periapical radiographs were taken with conventional film and two phosphor-plate systems (Vista Scan and Express)...
February 17, 2017: Dento Maxillo Facial Radiology
https://www.readbyqxmd.com/read/28211275/suppression-of-hydrogen-evolution-by-oxygen-reduction-in-nanoporous-electrocatalysts
#15
Ellen Benn, Bernard Gaskey, Jonah D Erlebacher
Electroreduction of small molecules in aqueous solution often competes with the hydrogen evolution reaction (HER), especially if the reaction is driven even moderately hard using a large overpotential. Here, the oxygen reduction reaction (ORR) was studied under proton diffusion-limited conditions in slightly acidic electrolytes - a model system to study the relative transport kinetics of protons and reactants to an electrocatalyst and the relationship between transport and catalytic performance. Using dealloyed nanoporous nickel-platinum (np-NiPt) electrodes, we find the hydrogen evolution reaction can be completely suppressed even at high overpotentials (-400 mV vs...
February 17, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28211190/technology-to-engage-hospitalised-patients-in-their-nutrition-care-a-qualitative-study-of-usability-and-patient-perceptions-of-an-electronic-foodservice-system
#16
S Roberts, A P Marshall, R Gonzalez, W Chaboyer
BACKGROUND: Active patient involvement in nutrition care may improve dietary intakes in hospital. Our team is developing an innovative programme allowing patients to self-assess and self-monitor their nutrition at the bedside. The present study aimed to assess usability and patient perceptions of an electronic foodservice system (EFS) for participating in nutrition care. METHODS: This qualitative study was conducted in an Australian tertiary hospital. Participants were sampled purposively and included patients who were able to provide informed consent and communicate in English...
February 16, 2017: Journal of Human Nutrition and Dietetics: the Official Journal of the British Dietetic Association
https://www.readbyqxmd.com/read/28210734/ceria-based-model-catalysts-fundamental-studies-on-the-importance-of-the-metal-ceria-interface-in-co-oxidation-the-water-gas-shift-co2-hydrogenation-and-methane-and-alcohol-reforming
#17
REVIEW
José A Rodriguez, David C Grinter, Zongyuan Liu, Robert M Palomino, Sanjaya D Senanayake
Model metal/ceria and ceria/metal catalysts have been shown to be excellent systems for studying fundamental phenomena linked to the operation of technical catalysts. In the last fifteen years, many combinations of well-defined systems involving different kinds of metals and ceria have been prepared and characterized using the modern techniques of surface science. So far most of the catalytic studies have been centered on a few reactions: CO oxidation, the hydrogenation of CO2, and the production of hydrogen through the water-gas shift reaction and the reforming of methane or alcohols...
February 17, 2017: Chemical Society Reviews
https://www.readbyqxmd.com/read/28209390/liquid-crystal-based-capillary-sensory-platform-for-the-detection-of-bile-acids
#18
Hyeong Jin Kim, Chang-Hyun Jang
Bile acids directly related to liver and intestinal function are used as indicators of hepatobiliary and intestinal diseases. Here, we have designed and realized a capillary sensory platform for the detection of bile acids using liquid crystals (LCs). LC droplets confined in micro-capillaries are homeotropically aligned at the surfactant-packed LC/aqueous interface. However, the competitive adsorption of bile acids disrupts the surfactant packing at this interface and triggers the orientational transition of the LC droplets from homeotropic to planar at the interface, followed by changes in optical images captured by polarized light microscopy...
February 13, 2017: Chemistry and Physics of Lipids
https://www.readbyqxmd.com/read/28208763/iterative-development-of-an-online-dietary-recall-tool-intake24
#19
Emma Simpson, Jennifer Bradley, Ivan Poliakov, Dan Jackson, Patrick Olivier, Ashley J Adamson, Emma Foster
Collecting large-scale population data on dietary intake is challenging, particularly when resources and funding are constrained. Technology offers the potential to develop novel ways of collecting large amounts of dietary information while making it easier, more convenient, intuitive, and engaging for users. INTAKE24 is an online multiple pass 24 h dietary recall tool developed for use in national food and nutrition surveys. The development of INTAKE24 was a four-stage iterative process of user interaction and evaluation with the intended end users, 11-24 years old...
February 9, 2017: Nutrients
https://www.readbyqxmd.com/read/28208734/towards-building-a-computer-aided-education-system-for-special-students-using-wearable-sensor-technologies
#20
Raja Majid Mehmood, Hyo Jong Lee
Human computer interaction is a growing field in terms of helping people in their daily life to improve their living. Especially, people with some disability may need an interface which is more appropriate and compatible with their needs. Our research is focused on similar kinds of problems, such as students with some mental disorder or mood disruption problems. To improve their learning process, an intelligent emotion recognition system is essential which has an ability to recognize the current emotional state of the brain...
February 8, 2017: Sensors
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