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https://www.readbyqxmd.com/read/29691953/circulating-mots-c-levels-are-decreased-in-obese-male-children-and-adolescents-and-associated-with-insulin-resistance
#1
Caiqi Du, Cai Zhang, Wei Wu, Yan Liang, Anru Wang, Shimin Wu, Yue Zhao, Ling Hou, Qin Ning, Xiaoping Luo
BACKGROUND AND AIMS: A novel bioactive peptide, mitochondrial-derived peptide (MOTS-c), has recently attracted attention as a potential prevention or therapeutic option for obesity and type 2 diabetes mellitus (T2DM). MOTS-c profiles have not yet been reported in human obesity and T2DM. We aimed to determine circulating MOTS-c levels in obesity and explore the association between MOTS-c levels and various metabolic parameters. METHODS: In this case-control study, 40 obese children and adolescents (27 males) and 57 controls (40 males) were recruited in the Hubei Province of China in 2017...
April 25, 2018: Pediatric Diabetes
https://www.readbyqxmd.com/read/29691912/effect-of-hybridization-with-genome-exclusion-on-extinction-risk
#2
Claudio S Quilodrán, Mathias Currat, Juan I Montoya-Burgos
Human-induced habitat changes may lead to the breakdown of reproductive barriers between distantly related species. This phenomenon may result in fertile first-generation hybrids (F1 ) that exclude the genome of one parental species during gametogenesis, thus disabling introgression. The species extinction risk associated with hybridization with genome exclusion is largely underappreciated because the phenomenon produces only F1 hybrid phenotype, leading to the misconception that hybrids are sterile and potentially of minor conservation concern...
April 24, 2018: Conservation Biology: the Journal of the Society for Conservation Biology
https://www.readbyqxmd.com/read/29691896/genome-wide-interaction-with-the-insulin-secretion-locus-mtnr1b-reveals-cmip-as-a-novel-type-2-diabetes-susceptibility-gene-in-african-americans
#3
Jacob M Keaton, Chuan Gao, Meijian Guan, Jacklyn N Hellwege, Nicholette D Palmer, James S Pankow, Myriam Fornage, James G Wilson, Adolfo Correa, Laura J Rasmussen-Torvik, Jerome I Rotter, Yii-Der I Chen, Kent D Taylor, Stephen S Rich, Lynne E Wagenknecht, Barry I Freedman, Maggie C Y Ng, Donald W Bowden
Although type 2 diabetes (T2D) results from metabolic defects in insulin secretion and insulin sensitivity, most of the genetic risk loci identified to date relates to insulin secretion. We reported that T2D loci influencing insulin sensitivity may be identified through interactions with insulin secretion loci, thereby leading to T2D. Here, we hypothesize that joint testing of variant main effects and interaction effects with an insulin secretion locus increases power to identify genetic interactions leading to T2D...
April 24, 2018: Genetic Epidemiology
https://www.readbyqxmd.com/read/29691890/synthesis-and-in-vitro-pdt-evaluation-of-new-porphyrins-containing-meso-epoxymethylaryl-cationic-groups
#4
Jaqueline Carneiro, Alan Gonçalves, Zehua Zhou, Kaitlin E Griffin, Nichole E M Kaufman, Maria da Graça Henriques Vicente
OBJECTIVES: Photodynamic therapy (PDT) is an effective cancer treatment that uses photosensitizers, light, and oxygen to destroy malignant cells. Porphyrins, and in particular the cationic derivatives, are the most investigated photosensitizers for PDT. In this context, it is important to study new methodologies to develop efficient cationic photosensitizers for use in PDT. MATERIALS AND METHODS: New porphyrins bearing cationic epoxymethylaryl groups were synthesized and characterized...
April 25, 2018: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/29691881/3-hydroxyflavone-enhances-the-toxicity-of-zno-nanoparticles-in-vitro
#5
Yunfeng Luo, Chaohua Wu, Liangliang Liu, Yu Gong, Shengming Peng, Yixi Xie, Yi Cao
It is recently shown that flavonoids might reduce the toxicity of nanoparticles (NPs) due to their antioxidative properties. In this study, the influence of 3-hydroxyflavone (H3) on the toxicity of ZnO NPs was investigated. H3 increased hydrodynamic size, polydispersity index and absolute value of the zeta potential of ZnO NPs, which indicated that H3 could influence the colloidal aspects of NPs. Surprisingly, H3 markedly decreased the initial concentration of ZnO NPs required to induce cytotoxicity to Caco-2, HepG2, THP-1 and human umbilical vein endothelial cells, which suggested that H3 could promote the toxicity of ZnO NPs to both cancerous and normal cells...
April 25, 2018: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/29691712/gc-formula-see-text-nmf-a-novel-matrix-factorization-framework-for-gene-phenotype-association-prediction
#6
Yaogong Zhang, Jiahui Liu, Xiaohu Liu, Yuxiang Hong, Xin Fan, Yalou Huang, Yuan Wang, Maoqiang Xie
Gene-phenotype association prediction can be applied to reveal the inherited basis of human diseases and facilitate drug development. Gene-phenotype associations are related to complex biological processes and influenced by various factors, such as relationship between phenotypes and that among genes. While due to sparseness of curated gene-phenotype associations and lack of integrated analysis of the joint effect of multiple factors, existing applications are limited to prediction accuracy and potential gene-phenotype association detection...
April 24, 2018: Interdisciplinary Sciences, Computational Life Sciences
https://www.readbyqxmd.com/read/29691615/seasonal-variation-and-exposure-risks-of-perchlorate-in-soil-indoor-dust-and-outdoor-dust-in-china
#7
Yiwen Li, Ruoying Liao, Zhiwei Gan, Bing Qu, Rong Wang, Mengqin Chen, Sanglan Ding, Shijun Su
A total of 97 paired soil, outdoor dust, and indoor dust samples were collected in the national scale of China in summer, and the perchlorate levels were compared with those in soil and outdoor dust samples collected in winter in our previous study. The median perchlorate concentrations in the outdoor dust, indoor dust, and soil samples were 8.10, 11.4, and 0.05 mg/kg, respectively, which were significantly lower than those in the winter samples due to the natural factors and human activities. No significant differences in perchlorate concentrations were found between Northern and Southern China in the dust samples, whereas the difference was obtained in the soil samples...
April 25, 2018: Archives of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/29691553/-klf10-silencing-inhibited-mechanical-force-induced-osteogenic-differentiation-of-human-periodontal-ligament-cells
#8
Xiao-Qin Yu, Yun-Long Li, Jin-Yu Gao, Hua Liu
PURPOSE: To investigate the effect of Klf10 silence on human periodontal ligament cells (HPDLCs) under mechanical force. METHODS: HPDLCs were isolated and transfected with Klf10 siRNA, and then exposed to centrifugal force for 6 h at 631 r/min. Purmorphamine, an hedgehog signaling pathway agonist, was used for intervention. The activity of alkaline phosphatase (ALP) was detected by ELISA. RT-PCR and Western blot were performed to detect the mRNA and protein expression of Klf10, Runt related transcription factor 2 (Runx2), osteopontin (OPN) and osteocalcin (OCN)...
December 2017: Shanghai Kou Qiang Yi Xue, Shanghai Journal of Stomatology
https://www.readbyqxmd.com/read/29691552/-cytotoxicity-of-3-resin-cements-to-human-gingival-fibroblasts
#9
Chang-Yuan Zhang, Gang Niu, Yi-Yi Jin, Hao Yu, Hui Cheng
PURPOSE: To study the cytotoxicity of 3 resin cements to human gingival fibroblasts (HGFs). METHODS: Three resin cements (Panavia F, RelyXTM Unicem and Multilink Speed) test samples were immersed and incubated in the culture medium for 48 h at 37degrees centigrade. Cultured HGFs were exposed to two concentrations (50% and 100%) of material elutes for 24 h, 72 h and 120 h. The proliferation rate was evaluated using CCK-8 assay. The data were statistically analyzed by one-way analysis of variance using SPSS 20...
December 2017: Shanghai Kou Qiang Yi Xue, Shanghai Journal of Stomatology
https://www.readbyqxmd.com/read/29691440/maternal-imprinting-on-cognition-markers-of-wild-type-and-transgenic-alzheimer-s-disease-model-mice
#10
Marta Zamarbide, Francisco J Gil-Bea, Paul Bannenberg, Eva Martínez-Pinilla, Juan Sandoval, Rafael Franco, Alberto Pérez-Mediavilla
The risk of suffering from Alzheimer's disease (AD) is higher in individuals from AD-affected mothers. The purpose of this investigation was to study whether maternal transmission might produce AD-related alterations in progenies of mice that do not have any genotypic alteration. We used cognitively-intact mothers harbouring in heterozygosity the transgene for overexpressing the Swedish double mutant version of the human amyloid precursor protein (hAβPPswe). The phenotype of the offspring with or without the transgene resulting from crossing young Tg2576 females with wild-type males were compared with those of the offspring resulting from crossing wild-type females with Tg2576 males...
April 24, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29691434/global-similarity-method-based-on-a-two-tier-random-walk-for-the-prediction-of-microrna-disease-association
#11
Min Chen, Bo Liao, Zejun Li
microRNAs (miRNAs) mutation and maladjustment are related to the occurrence and development of human diseases. Studies on disease-associated miRNA have contributed to disease diagnosis and treatment. To address the problems, such as low prediction accuracy and failure to predict the relationship between new miRNAs and diseases and so on, we design a Laplacian score of graphs to calculate the global similarity of networks and propose a Global Similarity method based on a Two-tier Random Walk for the prediction of miRNA-disease association (GSTRW) to reveal the correlation between miRNAs and diseases...
April 24, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29691417/rna-seq-analysis-of-interferon-inducible-p204-mediated-network-in-anti-tumor-immunity
#12
Jinlong Jian, Wei Wei, Guowei Yin, Aubryanna Hettinghouse, Chuanju Liu, Yongxiang Shi
p204, a murine member of the interferon-inducible p200 protein family, and its human analogue, IFI16, have been shown to function as tumor suppressors in vitro, but the molecular events involved, in particular in vivo, remain unclear. Herein we induced the Lewis Lung carcinoma (LLC) murine model of human lung cancer in p204 null mice (KO) and their control littermates (WT). We compared the transcriptome in spleen from WT and p204 KO mice using a high-throughput RNA-sequencing array. A total 30.02 Gb of clean data were obtained, and overall Q30% was greater than 90...
April 24, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29691385/deep-whole-genome-sequencing-reveals-recent-selection-signatures-linked-to-evolution-and-disease-risk-of-japanese
#13
Yukinori Okada, Yukihide Momozawa, Saori Sakaue, Masahiro Kanai, Kazuyoshi Ishigaki, Masato Akiyama, Toshihiro Kishikawa, Yasumichi Arai, Takashi Sasaki, Kenjiro Kosaki, Makoto Suematsu, Koichi Matsuda, Kazuhiko Yamamoto, Michiaki Kubo, Nobuyoshi Hirose, Yoichiro Kamatani
Understanding natural selection is crucial to unveiling evolution of modern humans. Here, we report natural selection signatures in the Japanese population using 2234 high-depth whole-genome sequence (WGS) data (25.9×). Using rare singletons, we identify signals of very recent selection for the past 2000-3000 years in multiple loci (ADH cluster, MHC region, BRAP-ALDH2, SERHL2). In large-scale genome-wide association study (GWAS) dataset (n = 171,176), variants with selection signatures show enrichment in heterogeneity of derived allele frequency spectra among the geographic regions of Japan, highlighted by two major regional clusters (Hondo and Ryukyu)...
April 24, 2018: Nature Communications
https://www.readbyqxmd.com/read/29691382/snord116-dependent-diurnal-rhythm-of-dna-methylation-in-mouse-cortex
#14
Rochelle L Coulson, Dag H Yasui, Keith W Dunaway, Benjamin I Laufer, Annie Vogel Ciernia, Yihui Zhu, Charles E Mordaunt, Theresa S Totah, Janine M LaSalle
Rhythmic oscillations of physiological processes depend on integrating the circadian clock and diurnal environment. DNA methylation is epigenetically responsive to daily rhythms, as a subset of CpG dinucleotides in brain exhibit diurnal rhythmic methylation. Here, we show a major genetic effect on rhythmic methylation in a mouse Snord116 deletion model of the imprinted disorder Prader-Willi syndrome (PWS). More than 23,000 diurnally rhythmic CpGs are identified in wild-type cortex, with nearly all lost or phase-shifted in PWS...
April 24, 2018: Nature Communications
https://www.readbyqxmd.com/read/29691375/thc-exposure-of-human-ipsc-neurons-impacts-genes-associated-with-neuropsychiatric-disorders
#15
Boris Guennewig, Maina Bitar, Ifeanyi Obiorah, James Hanks, Elizabeth A O'Brien, Dominik C Kaczorowski, Yasmin L Hurd, Panos Roussos, Kristen J Brennand, Guy Barry
There is a strong association between cannabis use and schizophrenia but the underlying cellular links are poorly understood. Neurons derived from human-induced pluripotent stem cells (hiPSCs) offer a platform for investigating both baseline and dynamic changes in human neural cells. Here, we exposed neurons derived from hiPSCs to Δ9 -tetrahydrocannabinol (THC), and identified diagnosis-specific differences not detectable in vehicle-controls. RNA transcriptomic analyses revealed that THC administration, either by acute or chronic exposure, dampened the neuronal transcriptional response following potassium chloride (KCl)-induced neuronal depolarization...
April 25, 2018: Translational Psychiatry
https://www.readbyqxmd.com/read/29691330/cortical-mechanisms-of-prioritizing-selection-for-rejection-in-visual-search
#16
Sarah E Donohue, Mandy V Bartsch, Hans-Jochen Heinze, Mircea A Schoenfeld, Jens-Max Hopf
In visual search, the more one knows about a target, the faster one can find it. Surprisingly, target identification is also faster with knowledge about distractor-features. The latter is paradoxical, as it implies that to avoid the selection of an item, the item must somehow be selected to some degree. This conundrum has been termed the 'ignoring paradox,' and, to date, little is known about how the brain resolves it. Here, in data from four experiments using neuromagnetic brain recordings in male and female humans, we provide evidence that this paradox is resolved by giving distracting information priority in cortical processing...
April 24, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29691221/small-ncrna-seq-results-of-human-tissues-variations-depending-on-sample-integrity
#17
Nicole Ludwig, Tobias Fehlmann, Valentina Galata, Andre Franke, Christina Backes, Eckart Meese, Andreas Keller
BACKGROUND: Although mature miRNAs are relatively stable in vivo, RNA degradation can have a substantial influence on small noncoding RNA (sncRNA) profiles. METHODS: Using different tissue storage conditions and RNA isolation procedures, we analyzed the integrity and quality of RNA isolates from human lung and heart tissues. We sequenced a total of 64 RNA samples and quantified the effect of RNA degradation, DNA contamination, and other confounding factors on the sncRNA-seq data...
April 24, 2018: Clinical Chemistry
https://www.readbyqxmd.com/read/29691127/digenic-heterozigosity-in-scn5a-and-cacna1c-explains-the-variable-expressivity-of-the-long-qt-phenotype-in-a-spanish-family
#18
Paloma Nieto-Marín, Juan Jiménez-Jáimez, David Tinaquero, Silvia Alfayate, Raquel G Utrilla, María Del Mar Rodríguez Vázquez Del Rey, Francesca Perin, Geòrgia Sarquella-Brugada, Lorenzo Monserrat, Josep Brugada, Luis Tercedor, Juan Tamargo, Eva Delpón, Ricardo Caballero
INTRODUCTION AND OBJECTIVES: A known long QT syndrome-related mutation in Nav1.5 cardiac channels (p.R1644H) was found in 4 members of a Spanish family but only 1 of them showed prolongation of the QT interval. In the other 3 relatives, a novel missense mutation in Cav1.2 cardiac channels was found (p.S1961N). Here, we functionally analyzed p.S1961N Cav1.2 channels to elucidate whether this mutation regulates the expressivity of the long QT syndrome phenotype in this family. METHODS: L-type calcium current (ICaL ) recordings were performed by using the whole-cell patch-clamp technique in Chinese hamster ovary cells transiently transfected with native and/or p...
April 21, 2018: Revista Española de Cardiología
https://www.readbyqxmd.com/read/29691107/-the-controversial-burkholderia-cepacia-complex-a-group-of-plant-growth-promoting-species-and-plant-animals-and-human-pathogens
#19
Fernando U Rojas-Rojas, David López-Sánchez, Georgina Meza-Radilla, Ausel Méndez-Canarios, J Antonio Ibarra, Paulina Estrada-de Los Santos
The Burkholderia cepacia complex is a group of 22 species, which are known as opportunistic pathogens in immunocompromised people, especially those suffering from cystic fibrosis. It is also found in nosocomial infections and is difficult to eradicate due to intrinsic resistance to several antibiotics. The species have large genomes (up to 9 Mbp), distributed into 2-5 replicons. These features significantly contribute to genome plasticity, which makes them thrive in different environments like soil, water, plants or even producing nodules in legume plants...
April 21, 2018: Revista Argentina de Microbiología
https://www.readbyqxmd.com/read/29691085/the-smyd3-vntr-3-3-polymorphism-confers-an-increased-risk-and-poor-prognosis-of-hepatocellular-carcinoma-in-a-chinese-population
#20
Rui-Dong Li, Yan-Hua Tang, Hui-Li Wang, Dong Yang, Li-Jun Sun, Wei Li
OBJECTIVE: Hepatocellular carcinoma (HCC) is one of the most lethal human malignancies in China, and the genetic link of hepatocarcinogenesis remains to be defined. Thus, we explored the role of SET and myeloid translocation protein 8, Nervy, and DEAF1 (MYND) domain containing protein 3 (SMYD3) gene polymorphism on risk and prognosis of HCC. METHODS: A total of 236 patients with HCC who received treatment in Affiliated Hospital of Jining Medical University for the first time and 230 healthy individuals were enrolled in the study...
April 17, 2018: Pathology, Research and Practice
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