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Multiple chemical sensitivity

Xian Luo, Mingrui An, Kyle C Cuneo, David M Lubman, Liang Li
Circulating exosomes in bodily fluids such as blood are being actively studied as a rich source of chemical biomarkers for cancer diagnosis and monitoring. While nucleic acid analysis is a primary tool for discovery of circulating biomarkers in exosomes, metabolomics holds the potential of expanding the chemical diversity of biomarkers that may be easy and rapid to detect. However, only trace amounts of exosomes can be isolated from a small volume of patient blood and thus a very sensitive technique is required to analyze the metabolome of exosomes...
June 19, 2018: Analytical Chemistry
Mang Lin, Shichang Kang, Robina Shaheen, Chaoliu Li, Shih-Chieh Hsu, Mark H Thiemens
Increased anthropogenic-induced aerosol concentrations over the Himalayas and Tibetan Plateau have affected regional climate, accelerated snow/glacier melting, and influenced water supply and quality in Asia. Although sulfate is a predominant chemical component in aerosols and the hydrosphere, the contributions from different sources remain contentious. Here, we report multiple sulfur isotope composition of sedimentary sulfates from a remote freshwater alpine lake near Mount Everest to reconstruct a two-century record of the atmospheric sulfur cycle...
June 18, 2018: Proceedings of the National Academy of Sciences of the United States of America
Xun Sun, H Jane Dyson, Peter E Wright
Aggregation of transthyretin (TTR) is the causative agent for TTR cardiomyopathy and polyneuropathy amyloidoses. Aggregation is initiated by dissociation of the TTR tetramer into a monomeric intermediate, which self-assembles into amyloid. The coupled multiple-step equilibria and low-concentration, aggregation-prone intermediates are challenging to probe using conventional assays. We report a 19 F-NMR assay that leverages a highly sensitive trifluoroacetyl probe at a strategic site that gives distinct 19 F chemical shifts for the TTR tetramer and monomeric intermediate and enables direct quantification of their populations during the aggregation process...
June 18, 2018: Proceedings of the National Academy of Sciences of the United States of America
Marie Thi Dao Tran, Sine Skovbjerg, Lars Arendt-Nielsen, Per Bech, Marianne Lunde, Jesper Elberling
Background Multiple chemical sensitivity (MCS) is a chronic, disabling condition characterized by recurrent multisystem symptoms triggered by common airborne chemicals. Evidence points towards abnormal sensory processing in the central nervous system (CNS) as a likely pathophysiological mechanism. No effective treatment has yet been reported, but clinical observations suggest that as pulsed electromagnetic fields (PEMF) is a treatment for some CNS disorders (depression and chronic pain), it may also be a treatment modality for MCS...
December 29, 2017: Scandinavian Journal of Pain
Linus Andersson
No abstract text is available yet for this article.
December 29, 2017: Scandinavian Journal of Pain
V Davydenko, I Starchenko, А Davydenko, V Trufanova, V Kuznetsov
The analysis of publications shows that diverse multiple factors can induce changes in taste sensitivity and the main irritants are the chemicals of different types. However, the study of the effect of the components of dental structural materials on the state of lingual mucosa, in particular, taste sensors, has not been fully elucidated to date. The purpose of the paper was the study of the effect of monomer of the "Ftoraks" base acrylic resin on the state of the rats' lingual mucosa within 2-4 weeks after its impact...
May 2018: Georgian Medical News
Ryohei Narumi, Keiko Masuda, Takeshi Tomonaga, Jun Adachi, Hiroki R Ueda, Yoshihiro Shimizu
High-sensitivity mass spectrometry approaches using selected reaction monitoring (SRM) or multiple reaction monitoring (MRM) methods are powerful tools for targeted quantitative proteomics-based investigation of dynamics in specific biological systems. Both high-sensitivity detection of low-abundance proteins and their quantification using this technique employ stable isotope-labeled peptide internal standards. Currently, there are various ways for preparing standards, including chemical peptide synthesis, cellular protein expression, and cell-free protein or peptide synthesis...
June 2018: Synthetic and Systems Biotechnology
Howard Hu, Cornelia Baines
No abstract text is available yet for this article.
June 2018: Canadian Family Physician Médecin de Famille Canadien
Mazhar Abbas, Muhammad Adil, Syed Ehtisham-Ul-Haque, Bushra Munir, Muhammad Yameen, Abdul Ghaffar, Ghulam Abbas Shar, M Asif Tahir, Munawar Iqbal
Vibrio fischeri bioluminescence inhibition bioassay (VFBIA) has been widely applied for the monitoring of toxicity on account of multiple advantages encompassing shorter test duration, sensitive, cost-effective and ease of operation. Moreover, this bioassay found to be equally applicable to all types of matrices (organic & inorganic compounds, metals, wastewater, river water, sewage sludge, landfill leachate, herbicides, treated wastewater etc.) for toxicity monitoring. This review highlights the apparent significance of Vibrio fischeri bioluminescence inhibition assay for ecotoxicological screening and evaluation of diverse chemical substances toxicity profile...
June 1, 2018: Science of the Total Environment
Hebatallah Ali, Robert Seidel, Marvin N Pohl, Bernd Winter
We report on electronic structure measurements of the interface between hematite nanoparticles (6 nm diameter) and aqueous solutions. Using soft X-ray photoelectron spectroscopy from a liquid microjet we detect valence and core-level photoelectrons as well as Auger electrons from liquid water, from the nanoparticle-water interface, and from the interior of the aqueous-phase nanoparticles. Most noteworthy, the method is shown to be sufficiently sensitive for the detection of adsorbed hydroxyl species, resulting from H2 O dissociation at the nanoparticle surface in aqueous solution...
May 21, 2018: Chemical Science
Siqi Zhang, Danielle Hagstrom, Patrick Hayes, Aaron Graham, Eva-Maria S Collins
There is an increased recognition in the field of toxicology of the value of medium-to-high-throughput screening methods using in vitro and alternative animal models. We have previously introduced the asexual freshwater planarian Dugesia japonica as a new alternative animal model and proposed that it is particularly well-suited for the study of developmental neurotoxicology. In this paper, we discuss how we have expanded and automated our screening methodology to allow for fast screening of multiple behavioral endpoints, developmental toxicity, and mortality...
June 8, 2018: Toxicological Sciences: An Official Journal of the Society of Toxicology
Sewoong Chung, Hyungseok Park, Jisu Yoo
Inland waters are substantial sources of atmospheric carbon, but relevant data are rare in Asian monsoon regions including Korea. Emissions of CO2 to the atmosphere depend largely on the partial pressure of CO2 (pCO2 ) in water; however, measured pCO2 data are scarce and calculated pCO2 can show large uncertainty. This study had three objectives: 1) to examine the spatial variability of pCO2 in diverse surface water systems in Korea; 2) to compare pCO2 calculated using pH-total alkalinity (Alk) and pH-dissolved inorganic carbon (DIC) with pCO2 measured by an in situ submersible nondispersive infrared detector; and 3) to characterize the major environmental variables determining the variation of pCO2 based on physical, chemical, and biological data collected concomitantly...
May 1, 2018: Science of the Total Environment
Shaowei Ding, Suprem R Das, Benjamin J Brownlee, Kshama Parate, Taylor M Davis, Loreen R Stromberg, Edward K L Chan, Joseph Katz, Brian D Iverson, Jonathan C Claussen
Vertically aligned carbon nanotube array (VANTA) coatings have recently garnered significant attention due in part to their unique material properties including light absorption, chemical inertness, and electrical conductivity. Herein we report the first use of VANTAs grown via chemical vapor deposition in a 2D interdigitated electrode (IDE) footprint with a high height-to-width aspect ratio (3:1 or 75:25 µm). The VANTA-IDEs were functionalized with an antibody (Ab) specific to the human cancerous inhibitor PP2A (CIP2A)-an oncoprotein that is associated with a variety of malignancies such as oral, breast, and multiple myeloma cancers...
April 8, 2018: Biosensors & Bioelectronics
Andreas Tittl, Aleksandrs Leitis, Mingkai Liu, Filiz Yesilkoy, Duk-Yong Choi, Dragomir N Neshev, Yuri S Kivshar, Hatice Altug
Metasurfaces provide opportunities for wavefront control, flat optics, and subwavelength light focusing. We developed an imaging-based nanophotonic method for detecting mid-infrared molecular fingerprints and implemented it for the chemical identification and compositional analysis of surface-bound analytes. Our technique features a two-dimensional pixelated dielectric metasurface with a range of ultrasharp resonances, each tuned to a discrete frequency; this enables molecular absorption signatures to be read out at multiple spectral points, and the resulting information is then translated into a barcode-like spatial absorption map for imaging...
June 8, 2018: Science
Ginny X H Li, Christine Vogel, Hyungwon Choi
While tandem mass spectrometry can detect post-translational modifications (PTM) at the proteome scale, reported PTM sites are often incomplete and include false positives. Computational approaches can complement these datasets by additional predictions, but most available tools use prediction models pre-trained for single PTM type by the developers and it remains a difficult task to perform large-scale batch prediction for multiple PTMs with flexible user control, including the choice of training data. We developed an R package called PTMscape which predicts PTM sites across the proteome based on a unified and comprehensive set of descriptors of the physico-chemical microenvironment of modified sites, with additional downstream analysis modules to test enrichment of individual or pairs of PTMs in protein domains...
June 7, 2018: Molecular omics
Abraham Yosipof, Rita C Guedes, Alfonso T García-Sosa
Data mining approaches can uncover underlying patterns in chemical and pharmacological property space decisive for drug discovery and development. Two of the most common approaches are visualization and machine learning methods. Visualization methods use dimensionality reduction techniques in order to reduce multi-dimension data into 2D or 3D representations with a minimal loss of information. Machine learning attempts to find correlations between specific activities or classifications for a set of compounds and their features by means of recurring mathematical models...
2018: Frontiers in Chemistry
Donald R Baer
Nanoparticles in a variety of forms are increasing important in fundamental research, technological and medical applications, and environmental or toxicology studies. Physical and chemical drivers that lead to multiple types of particle instabilities complicate both the ability to produce, appropriately characterize, and consistently deliver well-defined particles, frequently leading to inconsistencies, and conflicts in the published literature. This perspective suggests that provenance information, beyond that often recorded or reported, and application of a set of core characterization methods, including a surface sensitive technique, consistently applied at critical times can serve as tools in the effort minimize reproducibility issues...
2018: Frontiers in Chemistry
Anne Steinemann
Multiple chemical sensitivities (MCS) is a medical condition associated with exposure to common chemical pollutants. The aims of this study are to assess the prevalence of MCS, its overlaps with asthma and fragrance sensitivity, and its health and societal effects in Australia. Data were collected in June 2016 using an on-line survey with a representative national sample (N = 1098) of adults (ages 18-65) in Australia. Results found that, across the country, 6.5% report medically diagnosed MCS, 18.9% report chemical sensitivity (being unusually sensitive to everyday chemicals and chemically formulated products), and 19...
June 2018: Preventive Medicine Reports
Daniel Rodrigo, Andreas Tittl, Nadine Ait-Bouziad, Aurelian John-Herpin, Odeta Limaj, Christopher Kelly, Daehan Yoo, Nathan J Wittenberg, Sang-Hyun Oh, Hilal A Lashuel, Hatice Altug
A multitude of biological processes are enabled by complex interactions between lipid membranes and proteins. To understand such dynamic processes, it is crucial to differentiate the constituent biomolecular species and track their individual time evolution without invasive labels. Here, we present a label-free mid-infrared biosensor capable of distinguishing multiple analytes in heterogeneous biological samples with high sensitivity. Our technology leverages a multi-resonant metasurface to simultaneously enhance the different vibrational fingerprints of multiple biomolecules...
June 4, 2018: Nature Communications
José F Ek-Vitorín, Tasha K Pontifex, Janis M Burt
Connexin 43 (Cx43), a gap junction protein seemingly fit to support cardiac impulse propagation and synchronic contraction, is phosphorylated in normoxia by casein kinase 1 (CK1). However, during cardiac ischemia or pressure overload hypertrophy, this phosphorylation fades, Cx43 abundance decreases at intercalated disks and increases at myocytes' lateral borders, and the risk of arrhythmia rises. Studies in wild-type and transgenic mice indicate that enhanced CK1-phosphorylation of Cx43 protects from arrhythmia, while dephosphorylation precedes arrhythmia vulnerability...
June 4, 2018: International Journal of Molecular Sciences
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