Read by QxMD icon Read

Multiple chemical sensitivity

Martina Tripepi, Federico Capuana, Eliana Gianolio, Flavio Kock, Amerigo Pagoto, Rachele Stefania, Giuseppe Digilio, Silvio Aime
Molecular imaging requires the specific accumulation of contrast agents at the target. To exploit the superb resolution of MRI for applications in molecular imaging, gadolinium chelates, as the MRI contrast agents (CA), have to be conjugated to a specific vector able to recognize the epitope of interest. Several Gd(III)-chelates can be chemically linked to the same binding vector in order to deliver multiple copies of the CA (multimers) in a single targeting event thus increasing the sensitivity of the molecular probe...
February 22, 2018: Bioconjugate Chemistry
Tatiana Heid Furley, Julie Brodeur, Helena C Silva de Assis, Pedro Carriquiriborde, Katia R Chagas, Jone Corrales, Marina Denadai, Julio Fuchs, Renata Mascarenhas, Karina Sb Miglioranza, Diana Margarita Miguez Caramés, José Maria Navas, Danaythi Nugegoda, Estela Planes, Ignacio Alejandro Rodriguez-Jorquera, Martha Orozco-Medina, Alistair Ba Boxall, Murray A Rudd, Bryan W Brooks
The Global Horizon Scanning Project (GHSP) is an innovative initiative that aims to identify important global environmental quality research needs. Here we report 20 key research questions from Latin America (LA). Members of the Society of Environmental Toxicology and Chemistry (SETAC) LA and other scientists from LA were asked to submit research questions that would represent priority needs to address in the region. One hundred questions were received, then partitioned among categories, examined, and some rearranged during a workshop in Buenos Aires, Argentina...
February 22, 2018: Integrated Environmental Assessment and Management
Fei Zhang, Minghui Wang, Jianing Xi, Jianghong Yang, Ao Li
An enduring challenge in personalized medicine lies in selecting a suitable drug for each individual patient. Here we concentrate on predicting drug responses based on a cohort of genomic, chemical structure, and target information. Therefore, a recently study such as GDSC has provided an unprecedented opportunity to infer the potential relationships between cell line and drug. While existing approach rely primarily on regression, classification or multiple kernel learning to predict drug responses. Synthetic approach indicates drug target and protein-protein interaction could have the potential to improve the prediction performance of drug response...
February 20, 2018: Scientific Reports
Zinnat Shahina, Amira M El-Ganiny, Jessica Minion, Malcolm Whiteway, Taranum Sultana, Tanya E S Dahms
Background: Cinnamon ( Cinnamomum zeylanicum) bark extract exhibits potent inhibitory activity against Candida albicans but the antifungal mechanisms of this essential oil remain largely unexplored. Results: We analyzed the impact of cinnamon bark oil on C. albicans RSY150, and clinical strains isolated from patients with candidemia and candidiasis. The viability of RSY150 was significantly compromised in a dose dependent manner when exposed to cinnamon bark oil, with extensive cell surface remodelling at sub inhibitory levels (62...
2018: Fungal Biology and Biotechnology
Emeric Bron, Chloé Daudon, Jérôme Pety, François Levrier, Maryvonne Gerin, Pierre Gratier, Jan H Orkisz, Viviana Guzman, Sébastien Bardeau, Javier R Goicoechea, Harvey Liszt, Karin Öberg, Nicolas Peretto, Albrecht Sievers, Pascal Tremblin
Context: Previous attempts at segmenting molecular line maps of molecular clouds have focused on using position-position-velocity data cubes of a single molecular line to separate the spatial components of the cloud. In contrast, wide field spectral imaging over a large spectral bandwidth in the (sub)mm domain now allows one to combine multiple molecular tracers to understand the different physical and chemical phases that constitute giant molecular clouds (GMCs). Aims: We aim at using multiple tracers (sensitive to different physical processes and conditions) to segment a molecular cloud into physically/chemically similar regions (rather than spatially connected components), thus disentangling the different physical/chemical phases present in the cloud...
February 2018: Astronomy and Astrophysics
Shikha Sharma, Nidhi Singh, Vartika Tomar, Ramesh Chandra
Serotonin is one of the important neurotransmitters of our body. It's abnormal concentration is associated with multiple disorders and diseases. Sensitive and precise electrochemical determination of serotonin is not possible with bare working electrodes due to various reasons viz. electro-chemical fouling, presence of other biological molecules having similar oxidation potential, and lower concentration of serotonin in biological samples. Surface modification of working electrode is required for fast, precise, selective, and sensitive detection of serotonin...
February 6, 2018: Biosensors & Bioelectronics
Xinyue Wang, Tianbang Li, Makiko Kashio, Yijuan Xu, Makoto Tominaga, Tatsuhiko Kadowaki
Solenopsis invicta , the red imported fire ant, represents one of the most devastating invasive species. To understand their sensory physiology, we identified and characterized their Hymenoptera-specific (Hs) TRPA channel, SiHsTRPA. Consistent with the sensory functions of SiHsTRPA, it is activated by heat, an electrophile, and an insect repellent. Nevertheless, SiHsTRPA does not respond to most of the honey bee ortholog (AmHsTRPA)-activating compounds. The jewel wasp ortholog (NvHsTRPA) is activated by these compounds even though it outgroups both AmHsTRPA and SiHsTRPA...
January 2018: ENeuro
Shanshan Wu, Siying Wu, Zheyuan Yi, Fei Zeng, Weizhen Wu, Yuan Qiao, Xingzhong Zhao, Xing Cheng, Yanqing Tian
In this study, we developed fluorescent dual pH and oxygen sensors loaded in multi-well plates for in-situ and high-throughput monitoring of oxygen respiration and extracellular acidification during microbial cell growth for understanding metabolism. Biocompatible PHEMA-co-PAM materials were used as the hydrogel matrix. A polymerizable oxygen probe (OS2) derived from PtTFPP and a polymerizable pH probe (S2) derived from fluorescein were chemically conjugated into the matrix to solve the problem of the probe leaching from the matrix...
February 13, 2018: Sensors
Darshan C Patel, M Farooq Wahab, Thomas C O'Haver, Daniel W Armstrong
The virtue of chemical sensors is speed and analyte specificity. The response time to generate an analytical signal typically varies from ∼1 to 20 s, and they are generally limited to a single analyte. Chemical sensors are significantly affected by multiple interferents, matrix effects, temperature, and can vary widely in sensitivity depending on the sensor format. Separation-based analyses remove matrix effects and interferents and are compatible with multiple analytes. However, the speed of such analyses has not been commensurate with traditional sensors until now...
February 13, 2018: Analytical Chemistry
James B McGivney, Andrew T Csordas, Faye M Walker, Elizabeth R Bagley, Emily M Gruber, Peter L Mage, Jose Casas-Finet, Margaret A Nakamoto, Michael Eisenstein, Christopher J Larkin, Robert J Strouse, H Tom Soh
Biologic drugs are typically manufactured in mammalian host cells, and it is critical from a drug safety and efficacy perspective to detect and remove host cell proteins (HCPs) during production. This is currently achieved with sets of polyclonal antibodies (pAbs), but these suffer from critical shortcomings because their composition is inherently undefined, and they cannot detect nonimmunogenic HCPs. In this work, we report a high-throughput screening and array-based binding characterization strategy that we employed to generate a set of aptamers that overcomes these limitations to achieve sensitive, broad-spectrum detection of HCPs from the widely used Chinese hamster ovary (CHO) cell line...
February 13, 2018: Analytical Chemistry
Anja Paulick, Victor Sourjik
Most motile bacteria follow spatial gradients of chemical and physical stimuli in their environment. In Escherichia coli and other bacteria, the best characterized chemotaxis is in gradients of amino acids or sugars, but other physiological stimuli such as pH, osmolarity, redox potentials, and temperature are also known to elicit tactic responses. These multiple environmental stimuli are integrated and processed within a highly sophisticated chemotaxis network to generate coordinated chemotaxis behavior, which features high sensitivity, a wide dynamic range, and robustness against variations in background stimulation, protein levels, and temperature...
2018: Methods in Molecular Biology
Stacie Flood, JoAnn Burkholder, Greg Cope
Anthropogenic inputs of chemical environmental contaminants are frequently associated with developing harmful algal blooms, but little is known about how estuarine phytoplankton assemblages respond to multiple, co-occurring chemical stressors in chronically disturbed habitats. The goals of this research were to establish a robust protocol for testing the effects of atrazine on estuarine phytoplankton, and then to use that protocol to compare the effects of atrazine exposure with and without nutrient enrichment on a cosmopolitan estuarine/marine alga, Dunaliella tertiolecta (Chlorophyta)...
February 8, 2018: Environmental Science and Pollution Research International
Christopher L Frank, Jasmine P Brown, Kathleen Wallace, John F Wambaugh, Imran Shah, Timothy J Shafer
Measuring electrical activity of neural networks by microelectrode array (MEA) has recently shown promise for screening level assessments of chemical toxicity on network development and function. Important aspects of interneuronal communication can be quantified from a single MEA recording, including individual firing rates, coordinated bursting, and measures of network synchrony, providing rich datasets to evaluate chemical effects. Further, multiple recordings can be made from the same network, including during the formation of these networks in vitro...
February 2, 2018: Toxicology and Applied Pharmacology
Takahiko Katoh
Multiple chemical sensitivity (MCS), also known as idiopathic environmental intolerance, has been described as a chronic acquired disorder characterized by nonspecific symptoms in multiple organ systems and is associated with exposure to low-level chemicals. The name was established by Cullen, in 1987, although the name and diagnostic criteria are still under debate even now. A number of hypotheses concering the etiology and pathogenesis of MCS have been proposed, including impairmens of neurological, immunological and psychological systems...
2018: Nihon Eiseigaku Zasshi. Japanese Journal of Hygiene
Ruben R G Soares, Alessandra Ricelli, Corrado Fanelli, Domenico Caputo, Giampiero de Cesare, Virginia Chu, M Raquel Aires-Barros, João P Conde
The assurance of food and feed safety, including the identification and effective monitoring of multiple biological and chemical hazards, is a major societal challenge, given the increasing pace at which food commodities are demanded, produced and traded across the globe. Within this context, mycotoxins are globally widespread secondary fungal metabolites, which can contaminate crops either in the field or during storage and have serious human and animal health impacts such as carcinogenic, teratogenic and hepatotoxic effects...
January 31, 2018: Analyst
Libin Wang, Jun Zhao, Ruitao Zhang, Le Mi, Xin Shen, Nan Zhou, Tian Feng, Juan Jing, Xueying Liu, Shengyong Zhang
Currently, patients with co-infection with HIV and tuberculosis are treated with more than one drug. PA-824 a new chemical entity and a member of a class of compounds known as nitroimidazo-oxazines, has significant antituberculosis activity and a unique mechanism of action. Darunavir (PrezistaTM) is a new protease inhibitor of HIV-1. A simple, sensitive and rapid LC-MS-MS method has been developed and validated for simultaneous determination of PA-824 and darunavir. Chromatographic separation was achieved on Agilent Eclipse plus C18 column (100 mm × 2...
January 24, 2018: Journal of Chromatographic Science
Jia Zheng, Cunxian Xi, Shurui Cao, Guomin Wang, Bobin Tang, Zhi Wang, Zhaode Mu
A method for the simultaneous determination of 21 illegally added chemical drugs in improving sleep and immunity health foods using ultra performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) was developed. Oral liquid and health wine samples were shaken with acetonitrile and acetonitrile-water-formic acid (60:39:1, v/v/v), respectively, then purified by QuEChERS method. The extracts were separated on an Acquity UPLCTM BEH C18 column (50 mm×2.1 mm, 1.7 μm) with gradient elution of acetonitrile and 2 mmol/L ammonium acetate solution containing 0...
December 8, 2017: Se Pu, Chinese Journal of Chromatography
Davide Corinti, Barbara Gregori, Leonardo Guidoni, Debora Scuderi, Terry B McMahon, Barbara Chiavarino, Simonetta Fornarini, Maria Elisa Crestoni
The binding motifs in the halide adducts with tyrosine ([Tyr + X]-, X = Cl, Br, I) have been investigated and compared with the analogues with 3-nitrotyrosine (nitroTyr), a biomarker of protein nitration, in a solvent-free environment by mass-selected infrared multiple photon dissociation (IRMPD) spectroscopy over two IR frequency ranges, namely 950-1950 and 2800-3700 cm-1. Extensive quantum chemical calculations at B3LYP, B3LYP-D3 and MP2 levels of theory have been performed using the 6-311++G(d,p) basis set to determine the geometry, relative energy and vibrational properties of likely isomers and interpret the measured spectra...
January 26, 2018: Physical Chemistry Chemical Physics: PCCP
J Günther, F Brenne, M Droste, M Wendler, O Volkova, H Biermann, T Niendorf
Electron Beam Melting (EBM) is a powder-bed additive manufacturing technology enabling the production of complex metallic parts with generally good mechanical properties. However, the performance of powder-bed based additively manufactured materials is governed by multiple factors that are difficult to control. Alloys that solidify in cubic crystal structures are usually affected by strong anisotropy due to the formation of columnar grains of preferred orientation. Moreover, processing induced defects and porosity detrimentally influence static and cyclic mechanical properties...
January 22, 2018: Scientific Reports
Amanda Balboni Iniguez, Björn Stolte, Emily Jue Wang, Amy Saur Conway, Gabriela Alexe, Neekesh V Dharia, Nicholas Kwiatkowski, Tinghu Zhang, Brian J Abraham, Jaume Mora, Peter Kalev, Alan Leggett, Dipanjan Chowdhury, Cyril H Benes, Richard A Young, Nathanael S Gray, Kimberly Stegmaier
Many cancer types are driven by oncogenic transcription factors that have been difficult to drug. Transcriptional inhibitors, however, may offer inroads into targeting these cancers. Through chemical genomics screening, we identified that Ewing sarcoma is a disease with preferential sensitivity to THZ1, a covalent small-molecule CDK7/12/13 inhibitor. The selective CDK12/13 inhibitor, THZ531, impairs DNA damage repair in an EWS/FLI-dependent manner, supporting a synthetic lethal relationship between response to THZ1/THZ531 and EWS/FLI expression...
January 17, 2018: Cancer Cell
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"