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Multiple chemical sensitivity

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https://www.readbyqxmd.com/read/29019246/wearable-ring-based-sensing-platform-for-detecting-chemical-threats
#1
Juliane R Sempionatto, Rupesh K Mishra, Aida Martín, Guangda Tang, Tatsuo Nakagawa, Xiaolong Lu, Alan S Campbell, Kay Mengjia Lyu, Joseph Wang
This work describes a wireless wearable ring-based multiplexed chemical sensor platform for rapid electrochemical monitoring of explosive and nerve-agent threats in vapor and liquid phases. The ring-based sensor system consists of two parts: a set of printed electrochemical sensors and a miniaturized electronic interface, based on a battery-powered stamp-size potentiostat, for signal processing and wireless transmission of data. A wide range of electrochemical capabilities have thus been fully integrated into a 3D printed compact ring structure, toward performing fast square-wave voltammetry and chronoamperometric analyses, along with interchangeable screen-printed sensing electrodes for the rapid detection of different chemical threats...
October 11, 2017: ACS Sensors
https://www.readbyqxmd.com/read/29017328/the-tolerome-a-database-of-transcriptome-level-contributions-to-diverse-escherichia-coli-resistance-and-tolerance-phenotypes
#2
Keesha E Erickson, James D Winkler, Danh Nyugen, Ryan T Gill, Anushree Chatterjee
Tolerance and resistance are complex biological phenotypes that are desirable bioengineering goals for those seeking to design industrial strains or prevent the spread of antibiotic resistance. Over decades of research, a wealth of information has been generated to attempt to decode a molecular basis for tolerance, but to fully achieve the goal of engineering tolerance, researchers must be able to easily learn from a variety of data sources. To this end, we here describe a resource designed to enable scrutiny of diverse tolerance phenotypes...
October 10, 2017: ACS Synthetic Biology
https://www.readbyqxmd.com/read/29016195/critical-assessment-of-analytical-techniques-in-the-search-for-biomarkers-on-mars-a-mummified-microbial-mat-from-antarctica-as-a-best-case-scenario
#3
Yolanda Blanco, Ignacio Gallardo-Carreño, Marta Ruiz-Bermejo, Fernando Puente-Sánchez, Erika Cavalcante-Silva, Antonio Quesada, Olga Prieto-Ballesteros, Víctor Parro
The search for biomarkers of present or past life is one of the major challenges for in situ planetary exploration. Multiple constraints limit the performance and sensitivity of remote in situ instrumentation. In addition, the structure, chemical, and mineralogical composition of the sample may complicate the analysis and interpretation of the results. The aim of this work is to highlight the main constraints, performance, and complementarity of several techniques that have already been implemented or are planned to be implemented on Mars for detection of organic and molecular biomarkers on a best-case sample scenario...
October 10, 2017: Astrobiology
https://www.readbyqxmd.com/read/28994801/sequence-specific-and-selective-recognition-of-double-stranded-rnas-over-single-stranded-rnas-by-chemically-modified-peptide-nucleic-acids
#4
Desiree-Faye Kaixin Toh, Kiran M Patil, Gang Chen
RNAs are emerging as important biomarkers and therapeutic targets. Thus, there is great potential in developing chemical probes and therapeutic ligands for the recognition of RNA sequence and structure. Chemically modified Peptide Nucleic Acid (PNA) oligomers have been recently developed that can recognize RNA duplexes in a sequence-specific manner. PNAs are chemically stable with a neutral peptide-like backbone. PNAs can be synthesized relatively easily by the manual Boc-chemistry solid-phase peptide synthesis method...
September 21, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28980796/mechanism-of-surface-enhanced-raman-scattering-based-on-3d-graphene-tio2-nanocomposites-and-application-to-real-time-monitoring-of-telomerase-activity-in-differentiation-of-stem-cells
#5
Tingting Zheng, Enduo Feng, Zhiqiang Wang, Xueqing Gong, Yang Tian
With a burst development of new nanomaterials for plasmon-free surface-enhanced Raman scattering (SERS), the understanding of chemical mechanism (CM) and further applications have become more and more attractive. Herein, a novel SERS platform was specially designed through electrochemical deposition of graphene onto TiO2 nanoarrays (EG-TiO2). The developed EG-TiO2 nanocomposite SERS platform possessed remarkable Raman activity using copper phthalocyanine (CuPc) as a probe molecule. X-ray photoelectron spectroscopy measurement revealed that the chemical bond Ti-O-C was formed at the interface between graphene and TiO2 in EG-TiO2 nanocomposites...
October 13, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28978706/coat-protein-mutations-that-alter-the-flux-of-morphogenetic-intermediates-through-the-%C3%AF-x174-early-assembly-pathway
#6
Brody J Blackburn, Shuaizhi Li, Aaron P Roznowski, Alexis R Perez, Rodrigo H Villarreal, Curtis J Johnson, Margaret Hardy, Edward C Tuckerman, April D Burch, Bentley A Fane
Two scaffolding proteins orchestrate φX174 morphogenesis. The internal scaffolding protein B mediates the formation of pentameric assembly intermediates, whereas the external scaffolding protein D organizes 12 of these intermediates into procapsids. Aromatic amino acid side chains mediate most coat-internal scaffolding protein interactions. One residue in the internal scaffolding protein and three in the coat protein constitute the core of the B protein binding cleft. The three coat gene codons were randomized separately to ascertain the chemical requirements of the encoded amino acids and the morphogenetic consequences of mutation...
October 4, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28975958/a-programmable-soft-chemo-mechanical-actuator-exploiting-a-catalyzed-photochemical-water-oxidation-reaction
#7
P Yuan, J M McCracken, D E Gross, P V Braun, J S Moore, R G Nuzzo
We describe a composite hydrogel containing an embedding coupled chemistry for light-sensitized catalytic reactions that enables chemo-mechanical actuation of poly(acrylic acid)-based gels. In these materials, a photosensitizer and catalyst-ruthenium trisbipyridine and iridium dioxide nanoparticles, respectively-are incorporated into the hydrogel where together, with visible light irradiation, they undergo a catalytic water-oxidation reaction that lowers the pH and induces a dissipative/chemically-driven strain change in the gel...
October 4, 2017: Soft Matter
https://www.readbyqxmd.com/read/28973697/fenretinide-troglitazone-and-elmiron-add-to-weight-of-evidence-support-for-hemangiosarcoma-mode-of-action-from-studies-in-mice
#8
Jon C Cook, Leslie A Obert, Petra Koza-Taylor, Tim Coskran, Alan Opsahl, Daniel Ziemek, Marc Roy, Jessie Qian, Michael P Lawton, Kay Criswell
Pharmaceuticals and chemicals produce hemangiosarcomas (HS) in mice, often by nongenotoxic, proliferative mechanisms. A mode-of-action (MOA) for hemangiosarcoma was proposed based on information presented at an international workshop (Cohen et al., 2009). Five key elements of the MOA were articulated and included hypoxia, macrophage activation, increased angiogenic growth factors, dysregulated angiogenesis/erythropoiesis, and endothial cell proliferation. The goal of the current study was to add to the weight-of-evidence for the proposed MOA by assessing these key elements with three different compounds of varying potency for HS induction: fenretinide (high), troglitazone (intermediate), and elmiron (low)...
September 18, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28972786/absolute-quantification-of-amyloid-propagons-by-digital-microfluidics
#9
Manuela Pfammatter, Maria Andreasen, Georg Meisl, Christopher G Taylor, Jozef Adamcik, Sreenath Bolisetty, Antoni Sanchez-Ferrer, David Klenerman, Christopher M Dobson, Raffaele Mezzenga, Tuomas P J Knowles, Adriano A Aguzzi, Simone Hornemann
The self-replicating properties of numerous proteins into amyloid fibrils is a common phenomenon and underlies several neurodegenerative diseases. Because propagation-active fibrils are chemically indistinguishable from innocuous aggregates and monomeric precursors, their detection requires measurements of their replicative capacity. In the present study, we pre-sent a digital amyloid quantitative assay (d-Aqua) with insulin as amyloid model for the absolute quantification of single replicative units, propagons...
October 3, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28971204/toward-breath-analysis-on-a-chip-for-disease-diagnosis-using-semiconductor-based-chemiresistors-recent-progress-and-future-perspectives
#10
REVIEW
Ji-Wook Yoon, Jong-Heun Lee
Semiconductor gas sensors using metal oxides, carbon nanotubes, graphene-based materials, and metal chalcogenides have been reviewed from the viewpoint of the sensitive, selective, and reliable detection of exhaled biomarker gases, and perspectives/strategies to realize breath analysis on a chip for disease diagnosis are discussed based on the concurrent design of high-performance sensing materials and miniaturized pretreatment components. Carbon-based sensing materials that show relatively high responses to NO and NH3 at low or mildly raised temperatures can be applied to the diagnosis of asthma and renal disease...
October 3, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28960517/psychological-and-cognitive-effects-of-laser-printer-emissions-a-controlled-exposure-study
#11
Britta Herbig, Rudolf A Jörres, Rudolf Schierl, Myriam Simon, Jeanette Langner, Stefan Seeger, Dennis Nowak, Stefan Karrasch
The possible impact of ultrafine particles from laser printers on human health is controversially discussed although there are persons reporting substantial symptoms in relation to these emissions. A randomized, single-blinded, cross-over experimental design with two exposure conditions (high-level and low-level exposure) was conducted with 23 healthy subjects, 14 subjects with mild asthma, and 15 persons reporting symptoms associated with laser printer emissions. To separate physiological and psychological effects a secondary physiologically-based categorization of susceptibility to particle effects was used...
September 28, 2017: Indoor Air
https://www.readbyqxmd.com/read/28955000/levetiracetam-improves-symptoms-of-multiple-chemical-sensitivity-case-report
#12
Yosuke Kakisaka, Kazutaka Jin, Mayu Fujikawa, Yu Kitazawa, Kazuhiro Kato, Nobukazu Nakasato
Multiple chemical sensitivity (MCS) is a disorder of unknown etiology with no effective treatment. Many clinicians accept that a diagnosis of somatic symptoms disorder (SSD) is an appropriate diagnostic category for MCS. We found that administration of levetiracetam improved recurrent symptoms of MCS in a patient. A 23-year-old female presented with recurrent multiple symptoms of musculoskeletal, airway or mucous membrane, heart/chest-related, gastrointestinal, cognitive, affective, neuromuscular, head-related, and skin-related induced by exposure to diesel or gas engine exhaust, tobacco smoke, insecticide, gasoline, paint or paint thinner, cleaning products, fragrances, tar or asphalt, nail polish or hairspray, and new furnishings...
2017: Journal of Medical Investigation: JMI
https://www.readbyqxmd.com/read/28950703/multimodal-non-linear-optical-imaging-for-sensitive-detection-of-multiple-pharmaceutical-solid-state-forms-and-surface-transformations
#13
Dunja Novakovic, Jukka Kalle Samuel Saarinen, Tatu Petteri Rojalin, Osmo Antikainen, Sara Jane Fraser-Miller, Timo Laaksonen, Leena Peltonen, Antti Isomäki, Clare J Strachan
Two non-linear imaging modalities, coherent anti-Stokes Raman scattering (CARS) and sum-frequency generation (SFG), were successfully combined for sensitive multimodal imaging of multiple solid-state forms and their changes on drug tablet surfaces. Two imaging approaches were used and compared: (i) hyperspectral CARS combined with principal component analysis (PCA) and SFG imaging, and (ii) simultaneous narrowband CARS and SFG imaging. Three different solid-state forms of indomethacin - the crystalline gamma and alpha forms, as well as the amorphous form - were clearly distinguished using both approaches...
September 26, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28947319/ecological-risk-assessment-of-mixtures-of-radiological-and-chemical-stressors-methodology-to-implement-an-mspaf-approach
#14
Léa Beaumelle, Claire Della Vedova, Karine Beaugelin-Seiller, Jacqueline Garnier-Laplace, Rodolphe Gilbin
A main challenge in ecological risk assessment is to account for the impact of multiple stressors. Nuclear facilities can release both radiological and chemical stressors in the environment. This study is the first to apply species sensitivity distribution (SSD) combined with mixture models (concentration addition (CA) and independent action (IA)) to derive an integrated proxy of the ecological impact of combined radiological and chemical stressors: msPAF (multisubstance potentially affected fraction of species)...
September 22, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28941401/effect-based-assessment-of-toxicity-removal-during-wastewater-treatment
#15
Pia Välitalo, Riccardo Massei, Ilse Heiskanen, Peter Behnisch, Werner Brack, Andrew J Tindall, David Du Pasquier, Eberhard Küster, Anna Mikola, Tobias Schulze, Markus Sillanpää
Wastewaters contain complex mixtures of chemicals, which can cause adverse toxic effects in the receiving environment. In the present study, the toxicity removal during wastewater treatment at seven municipal wastewater treatment plants (WWTPs) was investigated using an effect-based approach. A battery of eight bioassays was applied comprising of cytotoxicity, genotoxicity, endocrine disruption and fish embryo toxicity assays. Human cell-based CALUX assays, transgenic larval models and the fish embryo toxicity test were particularly sensitive to WWTP effluents...
September 7, 2017: Water Research
https://www.readbyqxmd.com/read/28940940/tuning-excitonic-properties-of-monolayer-mos2-with-microsphere-cavity-by-high-throughput-chemical-vapor-deposition-method
#16
Yang Mi, Zhepeng Zhang, Liyun Zhao, Shuai Zhang, Jie Chen, Qingqing Ji, Jianping Shi, Xiebo Zhou, Rui Wang, Jia Shi, Wenna Du, Zhiyong Wu, Xiaohui Qiu, Qing Zhang, Yanfeng Zhang, Xinfeng Liu
Tuning the optical properties of 2D direct bandgap semiconductors is crucial for applications in photonic light source, optical communication, and sensing. In this work, the excitonic properties of molybdenum disulphide (MoS2 ) are successfully tuned by directly depositing it onto silica microsphere resonators using chemical vapor deposition method. Multiple whispering gallery mode (WGM) peaks in the emission wavelength range of ≈650-750 nm are observed under continuous wave excitation at room temperature...
September 20, 2017: Small
https://www.readbyqxmd.com/read/28940842/an-unsymmetrical-squaraine-dye-based-chemical-platform-for-multiple-analyte-recognition
#17
Ayyappanpillai Ajayaghosh, Divya Susan Philips, Samrat Ghosh, Karivachery V Sudheesh, Cherumuttathu H Suresh
Design of fluorescent molecular platforms capable of responding to multiple analytes is a topic of great interest. Herein, we report the use of a Zn2+-complexed unsymmetrical squaraine dye, Sq-Zn2+ as a chemical platform for recognizing structurally distinct analytes. The squaraine ring is substituted on one side with a dipicolylamine unit which acts as the metal ion receptor while the other part of the molecule carries a dibutyl aniline moiety which is an electron donor. The molecular system is unique as it could respond specifically to different types of analytes viz atmospheric carbon dioxide, cyclic phosphates and picric acid...
September 22, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28940334/uncovering-a-third-dissolved-phase-129-xe-resonance-in-the-human-lung-quantifying-spectroscopic-features-in-healthy-subjects-and-patients-with-idiopathic-pulmonary-fibrosis
#18
Scott H Robertson, Rohan S Virgincar, Elianna A Bier, Mu He, Geoffrey M Schrank, Rose Marie Smigla, Craig Rackley, H Page McAdams, Bastiaan Driehuys
PURPOSE: The purpose of this work was to accurately characterize the spectral properties of hyperpolarized (129) Xe in patients with idiopathic pulmonary fibrosis (IPF) compared to healthy volunteers. METHODS: Subjects underwent hyperpolarized (129) Xe breath-hold spectroscopy, during which 38 dissolved-phase free induction decays (FIDs) were acquired after reaching steady state (echo time/repetition time = 0.875/50 ms; bandwidth = 8.06 kHz; flip angle≈22 °)...
October 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28939123/development-of-polyurethane-based-passive-samplers-for-ambient-monitoring-of-urban-use-insecticides-in-water
#19
Chunyang Liao, Jaben Richards, Allison R Taylor, Jay Gan
Widespread use of insecticides for the control of urban pests such as ants, termites, and spiders has resulted in contamination and toxicity in urban aquatic ecosystems in different regions of the world. Passive samplers are a convenient and integrative tool for in situ monitoring of trace contaminants in surface water. However, the performance of a passive sampler depends closely on its affinity for the target analytes, making passive samplers highly specific to the types of contaminants being monitored. The goal of this study was to develop a passive sampler compatible with a wide range of insecticides, including the strongly hydrophobic pyrethroids and the weakly hydrophobic fipronil and organophosphates...
September 19, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28936868/a-microwave-flow-detector-for-gradient-elution-liquid-chromatography
#20
Duye Ye, Weizheng Wang, David Moline, Md Saiful Islam, Feng Chen, Pingshan Wang
This study presents a microwave flow detector technique for liquid chromatography (LC) application. The detector is based on a tunable microwave interferometer (MIM) with a vector network analyzer (VNA) for signal measurement and a computer for system control. A microstrip-line-based 0.3 μL flow cell is built and incorporated into the MIM. With syringe pump injection, the detector is evaluated by measuring a few common chemicals in DI water at multiple frequencies from 0.98 to 7.09 GHz. Less than 30 ng minimum detectable quantity (MDQ) is demonstrated...
October 3, 2017: Analytical Chemistry
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