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Biospecimen procurement

Elizabeth R Eisenhauer, Cynthia Arslanian-Engoren
Biobanking may include research procedures that violate the religious values and preferences of some patients. This integrative literature review evaluated the influence of religious values on participants' decisions to donate biospecimens to biobanks for research. The review followed the method of Whittemore and Knafl (2005). PubMed, CINAHL, and Google Scholar databases were searched for studies published between January 1, 1994 and March 31, 2014. The influence of religious values on decision making in biobanking included the following themes: (a) religious prohibitions, (b) pursuit of health, (c) decisional conflict, and (d) scope of consent...
2016: Research and Theory for Nursing Practice
Li Zhou, Daniel Catchpoole
The 'genomics era' is considered to have begun with the commencement of the Human Genome Project. As translational genomic studies can only be established when human tissue samples are available for analysis, biospecimens are now proven to be an essential element for their success. During the genomics era the necessity for more extensive biobanking infrastructure has been highlighted. With the increased number of genomic studies into cancer, it is considered that the availability of biospecimens will become the rate limiting step...
April 2015: Translational pediatrics
Latarsha J Carithers, Kristin Ardlie, Mary Barcus, Philip A Branton, Angela Britton, Stephen A Buia, Carolyn C Compton, David S DeLuca, Joanne Peter-Demchok, Ellen T Gelfand, Ping Guan, Greg E Korzeniewski, Nicole C Lockhart, Chana A Rabiner, Abhi K Rao, Karna L Robinson, Nancy V Roche, Sherilyn J Sawyer, Ayellet V Segrè, Charles E Shive, Anna M Smith, Leslie H Sobin, Anita H Undale, Kimberly M Valentino, Jim Vaught, Taylor R Young, Helen M Moore
The Genotype-Tissue Expression (GTEx) project, sponsored by the NIH Common Fund, was established to study the correlation between human genetic variation and tissue-specific gene expression in non-diseased individuals. A significant challenge was the collection of high-quality biospecimens for extensive genomic analyses. Here we describe how a successful infrastructure for biospecimen procurement was developed and implemented by multiple research partners to support the prospective collection, annotation, and distribution of blood, tissues, and cell lines for the GTEx project...
October 2015: Biopreservation and Biobanking
Thomas J Bell, Bill Leinweber
No abstract text is available yet for this article.
October 2015: Biopreservation and Biobanking
Marcel Kap, Anieta M Sieuwerts, Mikael Kubista, Monique Oomen, Shazia Arshad, Peter Riegman
The advent of molecular characterization of tissues has brought an increasing emphasis on the quality of biospecimens, starting with the tissue procurement process. RNA levels are particularly affected by factors in the collection process, but the influence of different pre-analytical factors is not well understood. Here we present the influence of tissue specimen size, as well as the transport and freezing protocols, on RNA quality. Large, medium, and smaller porcine liver samples were stored either dry, on moist gauze, or in salt solution for various times, and then frozen in either liquid nitrogen or in pre-cooled isopentane...
June 2015: Biopreservation and Biobanking
Sarah R Greytak, Kelly B Engel, B Paige Bass, Helen M Moore
Formalin-fixed and paraffin-embedded (FFPE) tissue biospecimens are a valuable resource for molecular cancer research. Although much can be gained from their use, it remains unclear whether the genomic and expression profiles obtained from FFPE biospecimens accurately reflect the physiologic condition of the patient from which they were procured, or if such profiles are confounded by biologic effects from formalin fixation and processing. To assess the physiologic accuracy of genomic and expression data generated with FFPE specimens, we surveyed the literature for articles investigating genomic and expression endpoints in case-matched FFPE and fresh or frozen human biospecimens using the National Cancer Institute's Biospecimen Research Database (http://biospecimens...
April 15, 2015: Cancer Research
Savitri Krishnamurthy
Biospecimen repositories are important for the advancement of biomedical research. Literature on the potential for biobanking of fine-needle aspiration, gynecologic, and nongynecologic cytology specimens is very limited. The potential for biobanking of these specimens as valuable additional resources to surgically excised tissues appears to be excellent. The cervicovaginal specimens that can be used for biobanking include Papanicolaou-stained monolayer preparations and residual material from liquid-based cytology preparations...
March 2015: Cancer Cytopathology
Jacob I Tower, Mark W Lingen, Tanguy Y Seiwert, Alexander Langerman
OBJECTIVES: To quantitatively and visually characterize changes in phosphorylated biomarker expression in head and neck squamous cell carcinoma specimens from excision through 90 minutes of warm ischemia. MATERIALS AND METHODS: Tissue biospecimens were procured prospectively. Head and neck squamous cell carcinoma specimens from 5 patients were subdivided into three parts upon excision, exposed to warm ischemia of 15, 30, or 90 minutes, and routinely biobanked. Relative change in biomarker expression of p-Akt, p-ERK, and p-Stat3 was measured by immunoblot densitometry...
2014: American Journal of Translational Research
William H Yong, Sarah M Dry, Maryam Shabihkhani
Powerful technologies critical to personalized medicine and targeted therapeutics require the analysis of carefully validated, procured, stored, and managed biospecimens. Reflecting advancements in biospecimen science, the National Cancer Institute and the International Society for Biological and Environmental Repositories are periodically publishing best practices that can guide the biobanker. The modern biobank will operate more like a clinical laboratory with formal accreditation, standard operating procedures, and quality assurance protocols...
2014: Methods in Molecular Biology
Jamie L'Heureux, Jeffrey C Murray, Elizabeth Newbury, Laura Shinkunas, Christian M Simon
PURPOSE: Human biospecimens are central to biobanking efforts, yet how members of the public think about biobank procurement strategies is not well understood. This study aimed to explore public perspectives toward the procurement of residual clinical material versus "direct" procurement strategies such as the drawing of blood. METHODS: Members of the public residing in and beyond the biobank catchment area of the University of Iowa Hospitals and Clinics were randomly selected to participate in focus groups and a telephone survey...
June 2013: Biopreservation and Biobanking
Idhaliz Flores, Teresita Muñoz-Antonia, Jaime Matta, Miosotis García, David Fenstermacher, Sylvia Gutierrez, Edward Seijo, Jose' Torres-Ruiz, W Jack Pledger, Domenico Coppola
Population-based studies are important to address emerging issues in health disparities among populations. The Partnership between the Moffitt Cancer Center (MCC) in Florida and the Ponce School of Medicine and Health Sciences (PSMHS) in Puerto Rico (the PSMHS-MCC Partnership) was developed to facilitate high-quality research, training, and community outreach focusing on the Puerto Rican population in the island and in the mainland, with funding from the National Cancer Institute. We report here the establishment of a Tissue Biobank at PSMHS, modeled after the MCC tissue biorepository, to support translational research projects on this minority population...
December 2011: Biopreservation and Biobanking
Martin Barr, Lina Souan, Peadar MacGabhann, Jeanette Müller, Maxim Al Ashhab, Mohammed Jasser, Khetam Hamza, Sallam Al Hassoon, Uwe Kuhn, Daniela Infante, Denise Lawlor, Kathy Gately, Eyad Amireh, Kenneth O'Byrne, Maher A Sughayer
Research studies aimed at advancing cancer prevention, diagnosis, and treatment depend on a number of key resources, including a ready supply of high-quality annotated biospecimens from diverse ethnic populations that can be used to test new drugs, assess the validity of prognostic biomarkers, and develop tailor-made therapies. In November 2011, KHCCBIO was established at the King Hussein Cancer Center (KHCC) with the support of Seventh Framework Programme (FP7) funding from the European Union (khccbio.khcc...
February 2014: Biopreservation and Biobanking
Elisa K Tong, Lei-Chun Fung, Susan L Stewart, Debora A Paterniti, Julie H T Dang, Moon S Chen
BACKGROUND: Biospecimen collection from diverse populations can advance cancer disparities research, but is currently underrepresented. METHODS: We partnered with a community-based clinic serving Cantonese-speaking Chinese Americans to develop and revise an educational seminar on biospecimen collection. Through a randomized controlled trial (n = 395), the intervention seminar was compared with a control seminar (cancer prevention) on change in willingness to donate biospecimens...
March 2014: Cancer Epidemiology, Biomarkers & Prevention
Kristen J Wells, Mariana Arevalo, Cathy D Meade, Clement K Gwede, Gwendolyn P Quinn, John S Luque, Gloria San Miguel, Dale Watson, Rebecca Phillips, Carmen Reyes, Margarita Romo, Jim West, Paul B Jacobsen
BACKGROUND: No validated multiscale instruments exist that measure community members' views on biobanking and biospecimen donation. This study describes the development and psychometric properties of the English-language BANKS (Biobanking Attitudes and Knowledge Survey). METHODS: The BANKS was created by item generation through review of scientific literature, focus groups with community members, and input from a community advisory board. Items were refined through cognitive interviews...
March 2014: Cancer Epidemiology, Biomarkers & Prevention
Veronique M Neumeister
Biospecimen science has recognized the importance of tissue quality for accurate molecular and biomarker analysis and efforts are made to standardize tissue procurement, processing and storage conditions of tissue samples. At the same time the field has emphasized the lack of standardization of processes between different laboratories, the variability inherent in the analytical phase and the lack of control over the pre-analytical phase of tissue processing. The problem extends back into tissue samples in biorepositories, which are often decades old and where documentation about tissue processing might not be available...
March 2014: Clinical Biochemistry
Maryam Shabihkhani, Gregory M Lucey, Bowen Wei, Sergey Mareninov, Jerry J Lou, Harry V Vinters, Elyse J Singer, Timothy F Cloughesy, William H Yong
Well preserved frozen biospecimens are ideal for evaluating the genome, transcriptome, and proteome. While papers reviewing individual aspects of frozen biospecimens are available, we present a current overview of experimental data regarding procurement, storage, and quality assurance that can inform the handling of frozen biospecimens. Frozen biospecimen degradation can be influenced by factors independent of the collection methodology including tissue type, premortem agonal changes, and warm ischemia time during surgery...
March 2014: Clinical Biochemistry
Mark Basik, Adriana Aguilar-Mahecha, Caroline Rousseau, Zuanel Diaz, Sabine Tejpar, Alan Spatz, Celia M T Greenwood, Gerald Batist
The majority of samples in existing tumour biobanks are surgical specimens of primary tumours. Insights into tumour biology, such as intratumoural heterogeneity, tumour-host crosstalk, and the evolution of the disease during therapy, require biospecimens from the primary tumour and those that reflect the patient's disease in specific contexts. Next-generation 'omics' technologies facilitate deep interrogation of tumours, but the characteristics of the samples can determine the ultimate accuracy of the results...
August 2013: Nature Reviews. Clinical Oncology
Sheng Hui Wu, Xiao Ou Shu, Wong-Ho Chow, Yong-Bing Xiang, Xianglan Zhang, Hong-Lan Li, Qiuyin Cai, Bu-Tian Ji, Hui Cai, Nathaniel Rothman, Yu-Tang Gao, Wei Zheng, Gong Yang
BACKGROUND: Soy and some of its constituents, such as isoflavones, have been shown to affect the inflammatory process in animal studies. The association between soy food intake and inflammatory markers has not been evaluated adequately in humans. OBJECTIVE: Our aim was to evaluate whether higher intake of soy foods was inversely associated with inflammatory markers in 1,005 middle-aged Chinese women. DESIGN: In this cross-sectional study, dietary intake of soy foods was assessed by a validated food frequency questionnaire and by a 24-hour recall when biospecimens were procured...
July 2012: Journal of the Academy of Nutrition and Dietetics
Sandra A McDonald, Mark A Watson, Joan Rossi, Colleen M Becker, David P Jaques, John D Pfeifer
Banking of high-quality, appropriately consented human tissue is crucial for the understanding of disease pathogenesis and translation of such knowledge into improvements in patient care. Traditionally, tissue banking has been thought of as primarily an academic research activity, but tissue and biospecimen banking is increasingly assuming clinical importance, especially with the advent of genetic and proteomic testing approaches that rely on fresh or fresh frozen tissue. These approaches are part of the revolution in personalized medicine...
November 2011: American Journal of Clinical Pathology
Elizabeth Sheldon, Kim Chi Vo, Ramsey A McIntire, Lusine Aghajanova, Zara Zelenko, Juan C Irwin, Linda C Giudice
OBJECTIVE: To develop a standard operating procedure (SOP) for collection, transport, storage of human endometrial tissue and blood samples, subject and specimen annotation, and establishing sample priorities. DESIGN: The SOP synthesizes sound scientific procedures, the literature on ischemia research, sample collection and gene expression profiling, good laboratory practices, and the authors' experience of workflow and sample quality. SETTING: The National Institutes of Health, University of California, San Francisco, Human Endometrial Tissue and DNA Bank...
May 2011: Fertility and Sterility
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