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JOURNAL ARTICLE
Mako Yanaga, Naomichi Okamoto, Reia Hashimoto, Ryohei Igata, Yuki Konishi, Atsuko Ikenouchi, Naoki Isomoto, Takahiro Shinkai, Masaru Harada, Reiji Yoshimura
BACKGROUND: Valproic acid (VPA) is a relatively safe drug widely used for the treatment of epileptic seizures and mania in bipolar disorder, as well as the prevention of migraine headaches. Here, we present a case of VPA-induced pancreatitis in a patient with vascular dementia, epileptic seizures, and psychiatric symptoms. He had no distinctive abdominal symptoms. CASE PRESENTATION: A 66-year-old Japanese man was treated with VPA for agitation and violent behavior due to vascular dementia, epileptic seizures, and psychiatric symptoms...
May 29, 2023: Journal of Medical Case Reports
#22
Maitri Patel, Jeremy P Middleton, Howard P Goodkin, Barrett Barnes, Emily McGowan, Ryan Eid
Cannabidiol is used in the care of treatment-resistant epilepsy. It has been associated with varying side effects, ranging from somnolence to diarrhea and weight loss. We present a patient on chronic cannabidiol therapy who had persistent diarrhea, abdominal pain, weight loss, and esophageal eosinophilia that improved with cannabidiol dose adjustment.
November 2022: JPGN reports
#23
JOURNAL ARTICLE
Blanca Talavera, Ganne Chaitanya, Norma Hupp, Sandipan Pati, Johnson P Hampson, Xi Luo, Jaison Hampson, Yash S Vakilna, M R Sandhya Rani, Rabeha Noor, John C Mosher, Nitin Tandon, Samden D Lhatoo, Nuria Lacuey
OBJECTIVE: We aimed to identify corticothalamic areas and electrical stimulation paradigms that optimally enhance breathing. METHODS: Twenty-nine patients with medically intractable epilepsy were prospectively recruited in an epilepsy monitoring unit while undergoing stereoelectroencephalographic evaluation. Direct electrical stimulation in cortical and thalamic regions was carried out using low (<1 Hz) and high (≥10 Hz) frequencies, and low (<5 mA) and high (≥5 mA) current intensities, with pulse width of ...
April 29, 2023: Epilepsia
#24
Ludovico Graziani, Giacomo Cinnirella, Valentina Ferradini, Chiara Conte, Federica Lo Bascio, Mario Bengala, Federica Sangiuolo, Giuseppe Novelli
Baraitser-Winter syndrome (BRWS) is a rare autosomal dominant disease (AD) caused by heterozygous variants in ACTB (BRWS1) or ACTG1 (BRWS2) genes. BRWS features developmental delay/intellectual disability of variable degree and craniofacial dysmorphisms. Brain abnormalities (especially pachygyria), microcephaly, epilepsy, as well as hearing impairment, cardiovascular and genitourinary abnormalities may be present. We report on a 4-year-old female, who was addressed to our institution because of psychomotor delay associated with microcephaly and dysmorphic features, short stature, mild bilateral sensorineural hearing loss, mild cardiac septal hypertrophy, and abdominal swelling...
February 21, 2023: American Journal of Medical Genetics. Part A
#25
JOURNAL ARTICLE
Xiuqin Xiong, Kim Dalziel, Li Huang, Brendan Mulhern, Natalie Carvalho
BACKGROUND: There is increasing interest in the validation of pediatric preference-based health-related quality of life measurement instruments. It is critical that children with various degrees of health-related quality of life (HRQoL) impact are included in validation studies. To inform patient sample selection for validation studies from a pragmatic perspective, this study explored HRQoL impairments between known-groups and HRQoL changes over time across 27 common chronic child health conditions and identified conditions with the largest impact on HRQoL...
January 25, 2023: Health and Quality of Life Outcomes
#26
Anas M Alrwashdeh, Prachi Saluja, Lana Hasan, Emily Kocurek, Ryan K Dare
OBJECTIVE: to describe a case of severe sepsis and complicated bacteremia caused by Arcanobacterium haemolyticum and review similar cases in the literature. CASE SUMMARY: A 26-year-old gentleman with a history of epilepsy presented with symptoms of sore throat, productive cough, periumbilical abdominal pain, watery diarrhea, nausea and vomiting, subjective fevers along with progressive jaundice for seven days. The patient had acute fulminant liver failure, septic shock, and Multi-organ failure...
2023: IDCases
#27
JOURNAL ARTICLE
Longfei You, Yiming Zhang, Dong Zhang, Lanlan Wang, Xiang Liu, Chang Peng, Yinbao Qi, Ruobing Qian
PURPOSE: To explore the localization value of drug-resistant temporal lobe epilepsy (TLE) aura for preoperative evaluation, based on stereoelectroencephalography (SEEG), and its prognostic value on the surgical outcome. METHODS: The data of patients with drug-resistant TLE who had SEEG electrodes implanted during preoperative evaluation at the First Affiliated Hospital of the University of Science and Technology of China (Hefei, China) were retrospectively analyzed...
January 2023: Epilepsy & Behavior: E&B
#28
Aldin Malkoc, Kerry E Fine, Ramisa Anjum, Joseph Vivian Davis
Blunt abdominal trauma is associated with a variety of medical complications. Traumatic abdominal wall hernias (TAWHs) are a rare sequela of blunt trauma. Of the various forms of TAWH, a rare subtype described as a "spontaneous lateral ventral hernia" or flank hernia occurs in less than 1% of all blunt abdominal traumas. We present a case of a 39-year-old male with a past medical history of epilepsy who was involved in a rollover motor vehicle collision. It was reported that the patient had a seizure while driving...
October 2022: Journal of Medical Cases
#29
JOURNAL ARTICLE
Lucy Loong, Agostina Tardivo, Alexej Knaus, Mona Hashim, Alistair T Pagnamenta, Kerstin Alt, Helena Böhrer-Rabel, Alfonso Caro-Llopis, Trevor Cole, Felix Distelmaier, Patrick Edery, Carlos R Ferreira, Aleksandra Jezela-Stanek, Bronwyn Kerr, Gerhard Kluger, Peter M Krawitz, Marius Kuhn, Johannes R Lemke, Gaetan Lesca, Sally Ann Lynch, Francisco Martinez, Caroline Maxton, Hanna Mierzewska, Sandra Monfort, Joost Nicolai, Carmen Orellana, Deb K Pal, Rafał Płoski, Oliver W Quarrell, Monica Rosello, Małgorzata Rydzanicz, Ataf Sabir, Robert Śmigiel, Alexander P A Stegmann, Helen Stewart, Constance Stumpel, Elżbieta Szczepanik, Andreas Tzschach, Lynne Wolfe, Jenny C Taylor, Yoshiko Murakami, Taroh Kinoshita, Allan Bayat, Usha Kini
PURPOSE: Biallelic PIGN variants have been described in Fryns syndrome, multiple congenital anomalies-hypotonia-seizure syndrome (MCAHS), and neurologic phenotypes. The full spectrum of clinical manifestations in relation to the genotypes is yet to be reported. METHODS: Genotype and phenotype data were collated and analyzed for 61 biallelic PIGN cases: 21 new and 40 previously published cases. Functional analysis was performed for 2 recurrent variants (c.2679C>G p...
November 2, 2022: Genetics in Medicine: Official Journal of the American College of Medical Genetics
#30
JOURNAL ARTICLE
Prashant A Natteru, Shoba Jayaram, Oriana Sanchez, Kyla Leon, Aditi Mishra, Christa O'Hana Nobleza
Refractory status epilepticus is commonly defined as status epilepticus that fails to respond to two or more appropriately dosed intravenous anti-seizure medications including at least one non-benzodiazepine drug. Super-refractory status epilepticus (SRSE) is when status epilepticus continues for ≥24 h despite anesthetic treatment or recurs on an attempted wean of the anesthetic drugs. There is little evidence to guide the management of SRSE. Of late, unconventional therapies have been described in the literature regarding the management of SRSE, with ketamine leading the pack...
October 25, 2022: Clinical EEG and Neuroscience: Official Journal of the EEG and Clinical Neuroscience Society (ENCS)
#31
JOURNAL ARTICLE
Weiwei Zhang, Xu Geng, Qing Dong, Xiuhan Li, Ping Ye, Mengyuan Lin, Bin Xu, Hong Jiang
ETHNOPHARMACOLOGICAL RELEVANCE: Realgar, the main component of which is As2 S2 or As4 S4 (≥90%), is a traditional Chinese natural medicine that has been used to treat carbuncles, furuncles, snake and insect bites, abdominal pain caused by parasitic worms, and epilepsy in China for many years. Because realgar contains arsenic, chronic or excessive use of single-flavor realgar and realgar-containing Chinese patent medicine can lead to drug-induced arsenic poisoning, but the exact mechanism underlying its toxicity to the central nervous system is unclear...
September 30, 2022: Journal of Ethnopharmacology
#32
REVIEW
Mohammed Al-Beltagi, Nermin Kamal Saeed
The brain and the gut are linked together with a complex, bi-path link known as the gut-brain axis through the central and enteric nervous systems. So, the brain directly affects and controls the gut through various neurocrine and endocrine processes, and the gut impacts the brain via different mechanisms. Epilepsy is a central nervous system (CNS) disorder with abnormal brain activity, causing repeated seizures due to a transient excessive or synchronous alteration in the brain's electrical activity. Due to the strong relationship between the enteric and the CNS, gastrointestinal dysfunction may increase the risk of epilepsy...
September 22, 2022: World Journal of Gastrointestinal Pathophysiology
#33
REVIEW
Mohammad Javad Emami Kazemabad, Sara Asgari Toni, Neda Tizro, Parisa Alsadat Dadkhah, Hanieh Amani, Shima Akhavan Rezayat, Zahra Sheikh, Mohammad Mohammadi, Dorsa Alijanzadeh, Farnoosh Alimohammadi, Mehregan Shahrokhi, Gisou Erabi, Masoud Noroozi, Mohammad Amin Karimi, Sara Honari, Niloofar Deravi
Age-related neurological disorders [AND] include neurodegenerative diseases [NDDs] such as Alzheimer's disease [AD] and Parkinson's disease [PD], which are the most prevalent types of dementia in the elderly. It also includes other illnesses such as migraine and epilepsy. ANDs are multifactorial, but aging is their major risk factor. The most frequent and vital pathological features of AND are oxidative stress, inflammation, and accumulation of misfolded proteins. As AND brain damage is a significant public health burden and its incidence is increasing, much has been done to overcome it...
2022: Frontiers in Aging Neuroscience
#34
Alexander Bertuccioli, Marco Cardinali, Francesco Di Pierro, Giordano Bruno Zonzini, Maria Rosaria Matera
Autism spectrum disorder (ASD) is often associated with several intestinal and/or metabolic disorders as well as neurological manifestations such as epilepsy (ASD-E). Those presenting these neuropathological conditions share common aspects in terms of gut microbiota composition. The use of microbiota intervention strategies may be an approach to consider in the management of these cases. We describe the case of a 17-year-old girl affected by ASD, reduced growth, neurological development delay, mutations in the PGM1 and EEF1A2 genes (in the absence of clinically manifested disease) and, intestinal disorders such as abdominal pain and diarrhea associated with weight loss...
August 8, 2022: International Journal of Molecular Sciences
#35
REVIEW
Katja Glutig, Ralf Husain, Diane Renz, Ulrike John-Kroegel, Hans-Joachim Mentzel
CLINICAL BACKGROUND: Tuberous sclerosis complex (TSC) is a phakomatosis and is a tumor predisposition syndrome. As a genetic multisystem disease, patients present with a broad range of changes in the brain, heart, skin, kidneys, and lungs. OBJECTIVES: Which imaging modalities are required to monitor TSC patients according to current international recommendations? MATERIALS AND METHODS: Common findings in TSC are cortical tubers, subependymal nodules, and giant cell astrocytomas in the central nervous system (CNS), rhabdomyomas in the heart, and cysts and angiomyolipomas in the kidneys...
August 9, 2022: Radiologie (Heidelb)
#36
JOURNAL ARTICLE
Max Ackerman, Arian Frost, Kimberly Stanford
BACKGROUND: Neutropenic enterocolitis (NE), or typhlitis, a condition typically associated with severe neutropenia in the setting of chemotherapy, is highly morbid (50-100%) and benefits from early diagnosis. It has been associated with neutropenia in the setting of human immunodeficiency virus (HIV) but has not been described in a patient with HIV who was not neutropenic on presentation. We present the case of a patient with HIV who was not neutropenic on presentation but found to have NE...
August 8, 2022: International Journal of Emergency Medicine
#37
REVIEW
Blanca Talavera, Norma J Hupp, Stephen Melius, Samden D Lhatoo, Nuria Lacuey
Multimodal polygraphy including cardiorespiratory monitoring in the Epilepsy Monitoring is becoming increasingly important. In addition to simultaneous recording of video and EEG, the combination of these techniques not only improves seizure detection, it enhances patient safety and provides information on autonomic clinical symptoms, which may be contributory to localization of seizure foci. However, there are currently no consensus guidelines, nor adequate information on devices available for multimodal polygraphy for cardiorespiratory monitoring in the Epilepsy Monitoring Unit...
September 2022: Epilepsy Research
#38
Xiuling Shang, Hongxuan Zhang, Sheng Chen, Chen Wang, Meifu Lin, Rongguo Yu
Background: Mycobacterium tuberculosis infection remains a public health concern worldwide. The diagnosis and treatment of disseminated M. tuberculosis is very difficult, so we shared our experiences and lessons learned in this case report. Case Presentation: A 36-year-old female with a history of epilepsy presented to our hospital with fever, upper abdominal pain, muscle soreness in limbs for 7 days, and shortness of breath for 4 days. On admission, she presented with acute respiratory distress syndrome (ARDS) and liver dysfunction...
2022: Frontiers in Public Health
#39
JOURNAL ARTICLE
Gonca Kılıç Yıldırım, Murat Yağcı, Anıl Çiğdem Uygur, Hülya Özen, Coşkun Yarar, Kürşat Bora Çarman
BACKGROUND: We evaluate here the effect of the ketogenic diet (KD) on children with drug-resistant epilepsy (DRE) in terms of clinical effectiveness, anthropometric measurements, and some electroencephalogram (EEG) and biochemical findings. METHODS: Included in the study were 18 children (median age 70 months, 61.1% female) who received the classical KD and modified Atkins diet (MAD) for at least one year due to DRE. The patients` demographic and laboratory data; weight, height and body mass index values; EEG and electrocardiographic findings; abdominal ultrasonography findings; and biochemical parameters were recorded at baseline and at 12 months after the initiation of the diet...
2022: Turkish Journal of Pediatrics
#40
JOURNAL ARTICLE
Chiara Fogliano, Chiara Maria Motta, Paola Venditti, Gianluca Fasciolo, Gaetana Napolitano, Bice Avallone, Rosa Carotenuto
Benzodiazepines, psychotropics drugs used for treating sleep disorders, anxiety and epilepsy, represent a major class of emerging water pollutants. As occurs for other pharmaceutical residues, they are not efficiently degraded during sewage treatment and persist in effluent waters. Bioaccumulation is already reported in fish and small crustaceans, but the impact and consequences on other "non-target" aquatic species are still unclear and nowadays of great interest. In this study, we investigated the effects of a pharmaceutical preparation containing the benzodiazepine delorazepam on the embryogenesis of Xenopus laevis, amphibian model species, taxa at high risk of exposure to water contaminants...
September 2022: Aquatic Toxicology
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