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Dementia and BPSD

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https://www.readbyqxmd.com/read/28177178/association-of-premorbid-personality-with-behavioral-and-psychological-symptoms-in-dementia-with-lewy-bodies-comparison-with-alzheimer-s-disease-patients
#1
Kazuki Tabata, Yasuaki Saijo, Fumiyoshi Morikawa, Juichiro Naoe, Eiji Yoshioka, Yasuyuki Kawanishi, Yoshihiko Nakagi, Takahiko Yoshida
AIM: The aim of this study was to elucidate the relationship between premorbid personality traits and behavioral and psychological symptoms in dementia (BPSD) in dementia with Lewy bodies (DLB) and Alzheimer's disease (AD) patients. METHODS: Forty-one DLB patients and 98 AD patients were assessed for BPSD using the Neuropsychiatric Inventory (NPI). Each patient's midlife personality traits were rated by a family member using the NEO Five-Factor Inventory (NEO-FFI) questionnaire...
February 8, 2017: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/28095946/electroconvulsive-therapy-ect-for-treating-agitation-in-dementia-major-neurocognitive-disorder-a-promising-option
#2
Oliver M Glass, Brent P Forester, Adriana P Hermida
BACKGROUND: Agitation in patients with dementia increases caretaker burden, increases healthcare costs, and worsens the patient's quality of life. Antipsychotic medications, commonly used for the treatment of agitation in patients with dementia have a box warning from the FDA for elevated mortality risk. Electroconvulsive therapy (ECT) has made significant advances over the past several years, and is efficacious in treating a wide range of psychiatric conditions. We provide a systematic review of published literature regarding the efficacy of ECT for the treatment of agitation in patients with dementia (major neurocognitive disorder)...
January 18, 2017: International Psychogeriatrics
https://www.readbyqxmd.com/read/28065176/behavioural-and-psychological-symptoms-in-general-hospital-patients-with-dementia-distress-for-nursing-staff-and-complications-in-care-results-of-the-general-hospital-study
#3
J B Hessler, M Schäufele, I Hendlmeier, M N Junge, S Leonhardt, J Weber, H Bickel
AIMS: Little is known about how behavioural and psychological symptoms of dementia (BPSD) manifest in the general hospital. The aim was to examine the frequency of BPSD in general hospitals and their associations with nursing staff distress and complications in care. METHODS: Cross-sectional representative study with 1469 patients aged ≥65, including 270 patients with dementia, of 33 randomly selected general hospitals in Germany. BPSD and complications were reported by nurses...
January 9, 2017: Epidemiology and Psychiatric Sciences
https://www.readbyqxmd.com/read/28049192/combined-memantine-and-donepezil-treatment-improves-behavioral-and-psychological-symptoms-of-dementia-like-behaviors-in-olfactory-bulbectomized-mice
#4
Yasushi Yabuki, Kazuya Matsuo, Koga Hirano, Yasuharu Shinoda, Shigeki Moriguchi, Kohji Fukunaga
Memantine, an uncompetitive N-methyl-D-aspartate receptor antagonist, and the cholinesterase inhibitor, donepezil, are approved in most countries for treating moderate-to-severe Alzheimer's disease (AD). These drugs have different molecular targets; thus, it is expected that the effects of combined treatment would be synergistic. Some reports do show memantine/donepezil synergy in ameliorating cognition in AD model animals, but their combined effects on behavioral and psychological symptoms of dementia (BPSD)-like behaviors have not been addressed...
January 4, 2017: Pharmacology
https://www.readbyqxmd.com/read/28035924/the-effect-of-the-association-between-donepezil-and-choline-alphoscerate-on-behavioral-disturbances-in-alzheimer-s-disease-interim-results-of-the-ascomalva-trial
#5
Anna Carotenuto, Raffaele Rea, Enea Traini, Angiola Maria Fasanaro, Giovanna Ricci, Valentino Manzo, Francesco Amenta
BACKGROUND: Behavioral and psychological symptoms of dementia (BPSD) are a group of psychological reactions, psychiatric symptoms, and behaviors commonly found in Alzheimer's disease (AD). Four clusters of BPSD have been described: mood disorders (depression, anxiety, and apathy), psychotic symptoms (delusions and hallucinations), aberrant motor behaviors (pacing, wandering, and other purposeless behaviors), and inappropriate behaviors (agitation, disinhibition, and euphoria). Most of them are attributed to acetylcholine deficiency...
December 30, 2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28009676/effectiveness-of-meaningful-occupation-interventions-for-people-living-with-dementia-in-residential-aged-care-a-systematic-review
#6
Catherine Travers, Deborah Brooks, Sonia Hines, Maria O'Reilly, Mitchell McMaster, Wei He, Margaret MacAndrew, Elaine Fielding, Lina Karlsson, Elizabeth Beattie
BACKGROUND: The ability to participate in valued activities, whether for work, leisure or family, is an important aspect of personal identity. In dementia, progressive memory loss means that abilities developed over a lifetime begin to be lost as well, contributing to the loss of self and identity. Some studies have reported that activities or interventions tailored to be meaningful to the person with dementia (defined as any activity important to the individual) are more effective in addressing behavioral and psychological symptoms of dementia (BPSD) and improving quality of life (QoL) than those that are not so tailored...
December 2016: JBI Database of Systematic Reviews and Implementation Reports
https://www.readbyqxmd.com/read/27998324/investigating-the-current-methods-of-assessing-behavioral-and-psychological-symptoms-in-residential-aged-care-facilities-in-a-metropolitan-city
#7
Samantha M Loi, Nicola T Lautenschlager
Up to 90% of people with dementia living in residential aged care facilities (RACFs) display behavioral and psychological symptoms of dementia (BPSD), and these are associated with poorer quality of life and increased morbidity and mortality. In order to implement appropriate interventions, it is important to understand the symptoms in more detail. Despite the availability of BPSD assessment tools, it is unknown what the current practice of monitoring of BPSD in RACFs. We sought to investigate the current BPSD assessment tools being used in RACFs and explore different stakeholders' views on current practices...
December 21, 2016: International Psychogeriatrics
https://www.readbyqxmd.com/read/27917740/delirium-superimposed-on-dementia-phenomenological-differences-between-patients-with-and-without-behavioral-and-psychological-symptoms-of-dementia-in-a-specialized-delirium-unit
#8
Jennifer Abengaña, Mei Sian Chong, Laura Tay
BACKGROUND: Overlap between neuropsychiatric symptoms of dementia and delirium complicates diagnosis of delirium superimposed on dementia (DSD). This study sought to examine differences in delirium presentation and outcomes between DSD patients with and without pre-existing behavioral and psychological symptoms of dementia (BPSD). METHODS: This was a prospective cohort study of older adults with DSD admitted to a specialized delirium unit (December 2010-August 2012)...
December 5, 2016: International Psychogeriatrics
https://www.readbyqxmd.com/read/27911304/effects-of-short-term-exercise-interventions-on-behavioral-and-psychological-symptoms-in-patients-with-dementia-a%C3%A2-systematic-review
#9
Tim Fleiner, Stefan Leucht, Hans Förstl, Wiebren Zijlstra, Peter Haussermann
Observational and interventional studies indicate a direct link between the patients' physical activity and the extent of behavioral and psychological symptoms of dementia (BPSD). At present, there are no evidence-based recommendations for physical exercise in the acute dementia care settings. Hence, this systematic review investigates the effects of short-term exercise trials on BPSD. Trials with a length up to three months investigating the effects of structured exercise interventions on BPSD in acute dementia care settings were included...
2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27899689/herbal-medicine-for-management-of-the-behavioural-and-psychological-symptoms-of-dementia-bpsd-a-systematic-review-and-meta-analysis
#10
REVIEW
Anna J Hyde, Brian H May, Lin Dong, Mei Feng, Shaonan Liu, Xinfeng Guo, Anthony Lin Zhang, Chuanjian Lu, Charlie Changli Xue
Management of the behavioural and psychological symptoms of dementia remains a challenge worldwide. Herbal medicines may play a role in the development of new interventions. To determine effects of herbal medicines for management of the behavioural and psychological symptoms of dementia, meta-analysis was conducted of 31 controlled trials (3613 participants). Frequently tested herbal medicines were the Ginkgo biloba leaf extract EGb 761 (seven studies) and the multi-ingredient formula Yokukansan (eight studies)...
November 29, 2016: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/27864478/patient-and-caregiver-interplay-in-behavioral-and-psychological-symptoms-of-dementia-family-caregiver-s-experience
#11
Jun-Ah Song, Myonghwa Park, Jaewon Park, Hong Jin Cheon, Mihyun Lee
The purpose of this study was to identify family caregivers' experiences in managing the behavioral and psychological symptoms of dementia (BPSD) with particular focus on their interpersonal interactions with patient with dementia. Data were collected through focus-group interviews with 15 family caregivers from three local dementia-support centers located in Seoul. Data were analyzed using content analysis. Three main themes were identified through data analysis: triggers of BPSD, family caregiver's actions in response to BPSD and patient's reactions, and the effect of BPSD on family caregivers...
November 17, 2016: Clinical Nursing Research
https://www.readbyqxmd.com/read/27849639/wecareadvisor%C3%A2-the-development-of-a-caregiver-focused-web-based-program-to-assess-and-manage-behavioral-and-psychological-symptoms-of-dementia
#12
Helen C Kales, Laura N Gitlin, Barbara Stanislawski, Katherine Marx, Molly Turnwald, Daphne C Watkins, Constantine G Lyketsos
BACKGROUND/OBJECTIVES: Behavioral and psychological symptoms of dementia (BPSD) are nearly universal in dementia and associated with multiple negative outcomes. Current real-world management is largely pharmacologic, despite poor risk/benefit. The WeCareAdvisor was designed to enable family caregivers to assess, manage, and track BPSD using nonpharmacologic strategies. DESIGN: In-depth qualitative data were collected from family caregivers of people with dementia to inform: (1) style of approach and "look and feel" of the tool, and (2) the types of psychoeducation most needed by caregivers...
November 15, 2016: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/27847922/treatment-of-behavioral-and-psychological-symptoms-of-dementia-a-systematic-review
#13
REVIEW
Ulrich W Preuss, Jessica W M Wong, G Koller
BPSD (Behavioral and Psychological Symptoms in Dementia) affects virtually all patients with dementia. The aim of this review is to present information on epidemiology, consequences and evidence-based non-pharmacological and pharmacological treatment approaches. The review also covers recent literature derived from a systematic literature Medline search on BPSD. Results indicate that BPSD are major risk factors for an earlier placement of affected individuals in nursing homes and a potentially more severe course of dementia over time...
2016: Psychiatria Polska
https://www.readbyqxmd.com/read/27806743/causes-of-nursing-home-placement-for-older-people-with-dementia-a-systematic-review-and-meta-analysis
#14
Sandeep Toot, Tom Swinson, Mike Devine, David Challis, Martin Orrell
BACKGROUND: Up to half of people with dementia in high income countries live in nursing homes and more than two-thirds of care home residents have dementia. Fewer than half of these residents report good quality of life and most older people are anxious about the prospect of moving into a nursing home. Robust evidence is needed as to the causes of admission to nursing homes, particularly where these risk factors are modifiable. METHODS: We conducted a systematic literature search to identify controlled comparison studies in which the primary outcome was admission to nursing home of older adults with dementia...
November 3, 2016: International Psychogeriatrics
https://www.readbyqxmd.com/read/27772752/role-of-neurodevelopment-involved-genes-in-psychiatric-comorbidities-and-modulation-of-inflammatory-processes-in-alzheimer-s-disease
#15
Porcelli Stefano, Crisafulli Concetta, Donato Luigi, Calabrò Marco, Politis Antonis, Liappas Ioannis, Albani Diego, Atti Anna Rita, Salfi Raffaele, Raimondi Ilaria, Forloni Gianluigi, Papadimitriou George N, De Ronchi Diana, Serretti Alessandro
INTRODUCTION: With the increase of the population's average age, Alzheimer's disease (AD) is becoming one of the most disabling diseases worldwide. Recently, neurodevelopment processes have been involved in the AD etiopathogenesis. Genetic studies in this field could contribute to our knowledge and suggest new molecular targets for possible treatments. METHODS: Our primary aim was to investigate the associations among single nucleotide polymorphisms (SNPs) within neurodevelopment related genes (BDNF, ST8SIA2, C15orf32, NCAPG2, ESYT2, WDR60, LOC154822, VIPR2, GSK3B, NR1I2, ZNF804A, SP4) and AD...
November 15, 2016: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/27713359/measurement-of-neuropsychiatric-symptoms-in-clinical-trials-targeting-alzheimer-s-disease-and-related-disorders
#16
Renaud David, Emmanuel Mulin, Patrick Mallea, Philippe H Robert
Behavioral and psychological symptoms (BPSD) are now known to be frequently associated to cognitive and functional decline in Alzheimer's disease and related disorders. They are present since the early stages of the disease and have negative impact on the disease process. BPSD assessment is crucial in clinical practice and also in future clinical trials targeting disease-modifying therapies for dementia. In this article, we will first review current assessment tools for BPSD, mainly global and domain-specific scales, and new assessment methods, currently available or in development, including new scales, diagnostic criteria and new technologies such as ambulatory actigraphy...
July 26, 2010: Pharmaceuticals
https://www.readbyqxmd.com/read/27665755/predicting-off-label-antipsychotic-medication-use-in-a-randomly-selected-nursing-home-sample-based-on-resident-and-facility-characteristics
#17
William E Mansbach, Ryan A Mace, Kristen M Clark, Isabella M Firth, Jacqueline K Breeden
Reducing off-label antipsychotic medication use for behavioral and psychological symptoms of dementia (BPSD) in nursing home residents has been a centerpiece of government regulation, but without insight into utilization differences based on resident and facility characteristics. To examine whether resident and facility characteristics can predict off-label antipsychotic medication treatment for BPSD, residents prescribed antipsychotic medication (N = 216) from 17 Maryland nursing facilities were randomly selected...
November 1, 2016: Research in Gerontological Nursing
https://www.readbyqxmd.com/read/27651011/pharmacological-treatments-of-behavioral-and-psychological-symptoms-of-dementia-in-alzheimer-s-disease-role-of-acetylcholinesterase-inhibitors-and-memantine
#18
Thomas Desmidt, Caroline Hommet, Vincent Camus
Behavioral and psychological symptoms of dementia (BPSD) are frequent in Alzheimer's disease (AD). They are associated with disability and suffering for both the patients and their caregivers. Even if BPSD are now well diagnosed and characterized by standardized tools, their treatment remains often challenging in clinical setting because of the frequent and severe side effects of the psychotropic drugs when used in this indication. Evidence-based data confirm that antipsychotics and antidepressants are efficient for the treatment of BPSD but have a poor tolerance profile and their use is problematic...
September 1, 2016: Gériatrie et Psychologie Neuropsychiatrie du Vieillissement
https://www.readbyqxmd.com/read/27634618/progress-in-bpsd-research-analyzing-individual-bpsd-might-hold-the-key-to-better-support-caregivers
#19
Nicola T Lautenschlager
Behavioral and Psychological Symptoms of Dementia (BPSD) or neuropsychiatric symptoms occur in more or less every person with dementia at some stage during the illness. They often have a significant impact on caregiver well-being and vice versa - caregivers response to BPSD can impact on the well-being of the care recipient with dementia (Feast et al., 2016A). The relationship between caregiver and care-recipient factors when it comes to BPSD is complex and more detailed research is needed to be able to progress to more effective interventions and support...
September 16, 2016: International Psychogeriatrics
https://www.readbyqxmd.com/read/27609932/pilot-testing-of-the-eit-4-bpsd-intervention
#20
Barbara Resnick, Ann Kolanowski, Kimberly Van Haitsma, Marie Boltz, Elizabeth Galik, Alice Bonner, Erin Vigne, Lauren Holtzman, Paula M Mulhall
Behavioral and psychological symptoms of dementia are common in nursing home residents, and the Centers for Medicare and Medicaid Services now require that nonpharmacological interventions be used as a first-line treatment. Few staff know how to implement these interventions. The purpose of this study was to pilot test an implementation strategy, Evidence Integration Triangle for Behavioral and Psychological Symptoms of Dementia (EIT-4-BPSD), which was developed to help staff integrate behavioral interventions into routine care...
November 2016: American Journal of Alzheimer's Disease and Other Dementias
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