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Dementia and BPSD

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https://www.readbyqxmd.com/read/29785228/evaluating-the-utility-of-a-structured-clinical-protocol-for-reducing-the-impact-of-behavioural-and-psychological-symptoms-of-dementia-in-progressive-neurological-diseases-a-pilot-study
#1
Nicholas P Ryan, Laura Scott, Maryanne McPhee, Susan Mathers, Marie-Claire Davis, Roxanne Maule, Fiona Fisher
Objectives: Behavioural and psychological symptoms of dementia (BPSD) cause significant distress to both aged care residents and staff. Despite the high prevalence of BPSD in progressive neurological diseases (PNDs) such as multiple sclerosis, Huntington's disease, and Parkinson's disease, the utility of a structured clinical protocol for reducing BPSD has not been systematically evaluated in PND populations. Method: Staff ( n = 51) and individuals with a diagnosis of PND ( n = 13) were recruited into the study, which aimed to evaluate the efficacy of a PND-specific structured clinical protocol for reducing the impact of BPSD in residential aged care (RAC) and specialist disability accommodation (SDA) facilities...
2018: Behavioural Neurology
https://www.readbyqxmd.com/read/29755923/epigenetic-alterations-impact-on-antipsychotic-treatment-in-elderly-patients
#2
Bryan M McClarty, Daniel W Fisher, Hongxin Dong
Purpose of the review: Antipsychotics are commonly prescribed for the treatment of psychosis as well as behavioral and psychological symptoms of dementia (BPSD) in elderly patients. However, elderly patients often experience decreased antipsychotic efficacy and increased side effects, though the mechanisms underlying these changes with age are not clear. Recent findings: Although aging can affect drug metabolism and clearance through changes in renal and hepatic function, additional pharmacokinetic and pharmacodynamic changes due to aging-induced epigenetic alterations also impact processes important for antipsychotic function...
March 2018: Current Treatment Options in Psychiatry
https://www.readbyqxmd.com/read/29755713/a-mobile-multimedia-reminiscence-therapy-application-to-reduce-behavioral-and-psychological-symptoms-in-persons-with-alzheimer-s
#3
Danish Imtiaz, Arshia Khan, Adriana Seelye
The goal of this project is to develop a novel and innovative mobile solution to address behavioral and psychological symptoms of dementia (BPSD) that occur in individuals with Alzheimer's. BPSD can include agitation, restlessness, aggression, apathy, obsessive-compulsive and repetitive behaviors, hallucinations, delusions, paranoia, and wandering. Alzheimer's currently affects 5.4 million adults in the United States and that number is projected to increase to 14 million by 2050. Almost 90% of all affected with AD experience BPSD, resulting in increased healthcare costs, heavier burden on caregivers, poor patient outcomes, early nursing home placement, long-term hospitalizations, and misuse of medications...
2018: Journal of Healthcare Engineering
https://www.readbyqxmd.com/read/29747583/effect-of-the-wecareadvisor%C3%A2-on-family-caregiver-outcomes-in-dementia-a-pilot-randomized-controlled-trial
#4
Helen C Kales, Laura N Gitlin, Barbara Stanislawski, H Myra Kim, Katherine Marx, Molly Turnwald, Claire Chiang, Constantine G Lyketsos
BACKGROUND: Behavioral and psychological symptoms of dementia (BPSD) are universal and associated with multiple negative outcomes. This pilot randomized controlled trial (RCT) evaluated the effect of using the WeCareAdvisor, an innovative web-based tool developed to enable family caregivers to assess, manage, and track BPSD. METHODS: This RCT enrolled 57 dementia family caregivers from community and clinical settings in Ann Arbor, Michigan and Baltimore, Maryland...
May 10, 2018: BMC Geriatrics
https://www.readbyqxmd.com/read/29735875/-predictors-of-behavioral-and-psychological-symptoms-of-dementia-based-on-the-model-of-multi-dimensional-behavior
#5
Jeong Eun Yang, Gwi Ryung Son Hong
PURPOSE: The purpose of this study was to identify factors predicting behavioral and psychological symptoms of dementia (BPSD) in persons with dementia. Factors including the patient, caregiver, and environment based on the multi-dimensional behavioral model were tested. METHODS: The subjects of the study were 139 pairs of persons with dementia and their caregivers selected from four geriatric long-term care facilities located in S city, G province, Korea. Data analysis included descriptive statistics, inverse normal transformations, Pearson correlation coefficients, Spearman's correlation coefficients and hierarchical multiple regression with the SPSS Statistics 22...
April 2018: Journal of Korean Academy of Nursing
https://www.readbyqxmd.com/read/29720286/impact-of-brief-education-on-healthy-seniors-attitudes-and-healthcare-choices-about-alzheimer-s-disease-and-associated-symptoms
#6
Robyn E Waxman, Barbara J Russell, Oscar C T Iu, Benoit H Mulsant
ABSTRACTObjective:The primary objective of this study was to determine whether a brief education session about Alzheimer's disease (AD) stages and associated behavioral and psychological symptoms of dementia (BPSD) changes healthy seniors' treatment choices. A secondary objective was to determine whether pharmacotherapy to reduce BPSD would be preferred over other potentially more restrictive interventions. METHODS: Participants (n = 32; 8 men; aged > 64years; no self-reported dementia diagnosis) were assigned to one of ten group sessions during which they received information about AD and BPSD...
May 3, 2018: International Psychogeriatrics
https://www.readbyqxmd.com/read/29706989/caregiver-burden-in-semantic-dementia-with-right-and-left-sided-predominant-cerebral-atrophy-and-in-behavioral-variant-frontotemporal-dementia
#7
Asuka Koyama, Mamoru Hashimoto, Ryuji Fukuhara, Naoko Ichimi, Akihiro Takasaki, Masateru Matsushita, Tomohisa Ishikawa, Hibiki Tanaka, Yusuke Miyagawa, Manabu Ikeda
Background: Caregiver burden is a serious concern for family caregivers of dementia patients, but its nature is unclear in patients with semantic dementia (SD). This study aimed to clarify caregiver burden for right- (R > L) and left-sided (L > R) predominant SD versus behavioral-variant frontotemporal dementia (bvFTD) patients. Methods: Using the Japanese version of the Zarit Burden Interview (ZBI) and the Neuropsychiatric Inventory, we examined caregiver burden and behavioral and psychological symptoms of dementia (BPSD) in 43 first-visit outpatient/family caregiver dyads (bvFTD, 20 dyads; SD [L > R], 13 dyads; SD [R > L], 10 dyads)...
January 2018: Dementia and Geriatric Cognitive Disorders Extra
https://www.readbyqxmd.com/read/29695193/efficacy-and-safety-of-atypical-antipsychotics-for-behavioral-and-psychological-symptoms-of-dementia-among-community-dwelling-adults
#8
Katy E Trinkley, Allison M Sturm, Kyle Porter, Milap C Nahata
INTRODUCTION: Options for the treatment of the behavioral and psychological symptoms of dementia (BPSD) are limited. Atypical antipsychotics are often used but have questionable efficacy and are generally considered high risk. Therefore, the objective of this study is to evaluate the efficacy and safety of using any atypical antipsychotic for the treatment of BPSD among outpatients. METHODS: Retrospective observational study of an academic outpatient memory disorders clinic...
January 1, 2018: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/29689719/the-behavioral-and-psychological-symptoms-of-dementia-in-down-syndrome-bpsd-ds-scale-comprehensive-assessment-of-psychopathology-in-down-syndrome
#9
Alain D Dekker, Silvia Sacco, Angelo Carfi, Bessy Benejam, Yannick Vermeiren, Gonny Beugelsdijk, Mieke Schippers, Lyanne Hassefras, José Eleveld, Sharina Grefelman, Roelie Fopma, Monique Bomer-Veenboer, Mariángeles Boti, G Danielle E Oosterling, Esther Scholten, Marleen Tollenaere, Laura Checkley, André Strydom, Gert Van Goethem, Graziano Onder, Rafael Blesa, Christine Zu Eulenburg, Antonia M W Coppus, Anne-Sophie Rebillat, Juan Fortea, Peter P De Deyn
People with Down syndrome (DS) are prone to develop Alzheimer's disease (AD). Behavioral and psychological symptoms of dementia (BPSD) are core features, but have not been comprehensively evaluated in DS. In a European multidisciplinary study, the novel Behavioral and Psychological Symptoms of Dementia in Down Syndrome (BPSD-DS) scale was developed to identify frequency and severity of behavioral changes taking account of life-long characteristic behavior. 83 behavioral items in 12 clinically defined sections were evaluated...
April 16, 2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29685175/general-practitioners-knowledge-attitudes-and-experiences-of-managing-behavioural-and-psychological-symptoms-of-dementia-protocol-of-a-mixed-methods-systematic-review-and-meta-ethnography
#10
Aisling A Jennings, Tony Foley, Kieran A Walsh, Alice Coffey, John P Browne, Colin P Bradley
BACKGROUND: In the context of rising dementia prevalence, the workload of general practitioners (GPs) in dementia care is set to increase. However, there are many aspects of dementia care that GPs find challenging. Behavioural and psychological symptoms of dementia (BPSD) affect the majority of people with dementia and is an aspect of dementia care that GPs find particularly difficult to manage. The aim of this mixed methods systematic review is to undertake a synthesis of qualitative and quantitative studies on GPs' knowledge, attitudes and experiences of managing BPSD...
April 23, 2018: Systematic Reviews
https://www.readbyqxmd.com/read/29671901/using-dolls-for-therapeutic-purposes-a-study-on-nursing-home-residents-with-severe-dementia
#11
A Cantarella, E Borella, S Faggian, A Navuzzi, R De Beni
OBJECTIVES: Among the psychosocial interventions intended to reduce the behavioral and psychological symptoms of dementia (BPSD), doll therapy (DT) is increasingly used in clinical practice. Few studies on DT have been based on empirical data obtained with an adequate procedure; however, none have assessed its efficacy using an active control group, and the scales used to assess changes in BPSD are usually unreliable. The aim of the present study was to measure the impact of DT on people with severe dementia with a reliable, commonly used scale for assessing their BPSD, and the related distress in formal caregivers...
April 19, 2018: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/29671334/alzheimer-disease-non-pharmacological-and-pharmacological-management-of-cognition-and-neuropsychiatric-symptoms
#12
Samantha M Loi, Dhamidhu Eratne, Wendy Kelso, Dennis Velakoulis, Jeffrey Cl Looi
OBJECTIVES: This clinical update review focuses on the management of cognition and the neuropsychiatric features of Alzheimer's disease (AD) and highlights current issues regarding pharmacological and non-pharmacological treatment, putative therapeutics and recent relevant research findings in this area. CONCLUSIONS: AD is a neurodegenerative progressive condition characterised by cognitive impairment and functional decline. Most people with AD will demonstrate neuropsychiatric features, better known as behavioural and psychological symptoms of dementia (BPSD)...
March 1, 2018: Australasian Psychiatry: Bulletin of Royal Australian and New Zealand College of Psychiatrists
https://www.readbyqxmd.com/read/29572105/-behavioral-and-psychological-symptoms-of-dementia-bpsd-and-impaired-cognition-reflect-unsuccessful-neuronal-compensation-in-the-pre-plaque-stage-and-serve-as-early-markers-for-alzheimer-s-disease-in-the-app23-mouse-model
#13
Anna Pfeffer, Tonia Munder, Stefanie Schreyer, Charlotte Klein, Justyna Rasińska, York Winter, Barbara Steiner
Recent research on Alzheimer's disease (AD) focuses on processes prior to amyloid-beta plaque deposition accounting for the progress of the disease. However, early mechanisms of AD are still poorly understood and predictors of the disease in the pre-plaque stage essential for initiating an early therapy are lacking. Behavioral and psychological symptoms of dementia (BPSD) and potentially impaired cognition may serve as predictors and early clinical diagnostic markers for AD. To investigate potential BPSD and cognitive impairments in association with neuronal cell development as such markers for AD in the pre-plaque stage, female APP23 mice at eight, 19 and 31 weeks of age and corresponding control animals were tested for BPSD (elevated zero maze; sucrose preference test), motor coordination (rotarod), spatial memory and reversal learning (Morris water maze) and hippocampal neurogenesis as a neuronal correlate for hippocampus-dependent behavior...
March 20, 2018: Behavioural Brain Research
https://www.readbyqxmd.com/read/29557193/managing-behavioural-and-psychological-symptoms-in-community-dwelling-older-people-with-dementia-2-a-systematic-review-of-qualitative-studies
#14
Andreas Braun, Daksha P Trivedi, Angela Dickinson, Laura Hamilton, Claire Goodman, Heather Gage, Kunle Ashaye, Steve Iliffe, Jill Manthorpe
Background People living with dementia often develop distressing behavioural and psychological symptoms (BPSD) that can affect their quality of life and the capacity of family carers and staff providing support at home. This systematic review of qualitative studies considers the views and experiences of people living with dementia and care providers about these symptoms and what helps to reduce their impact. Methods The two-stage review involved (a) An initial mapping of the literature to understand the range of BPSD, and how it is operationalised by different groups, to develop a search strategy; (b) A search of electronic databases from January 2000 to March 2015, updated in October 2016...
January 1, 2018: Dementia
https://www.readbyqxmd.com/read/29544342/tele-savvy-an-online-program-for-dementia-caregivers
#15
Patricia C Griffiths, Mariya Kovaleva, Melinda Higgins, Ashley H Langston, Kenneth Hepburn
INTRODUCTION: This study examined the feasibility and efficacy of Tele-Savvy, an online version of the Savvy Caregiver Program, a psychoeducation program for caregivers caring for a person with dementia. METHODS: A convenience sample of 22 caregivers from the Atlanta VA and 42 caregivers from 14 different states enrolled in Tele-Savvy. Pre- and post-program evaluations assessed caregiver burden, caregiver competency, and frequency of behavioral and psychological symptoms of dementia (BPSD)...
January 1, 2018: American Journal of Alzheimer's Disease and Other Dementias
https://www.readbyqxmd.com/read/29519963/-non-pharmacological-interventions-to-treat-clinical-symptoms-in-patients-with-dementia
#16
Hiroaki Kazui
Previous systematic reviews of non-pharmacological interventions for clinical symptoms in dementia patients have confirmed the effectiveness of cognitive stimulation therapy (CST) for cognitive impairment, exercise therapy for activities of daily living, and music therapy and behavior management techniques for behavioral and psychological symptoms of dementia (BPSD). A Japanese version of CST has been developed and is available, but standardized exercise therapy and music therapy have not been developed. It is also important for informal and formal caregivers to learn behavior management techniques...
March 2018: Brain and Nerve, Shinkei Kenkyū No Shinpo
https://www.readbyqxmd.com/read/29507257/supporting-regional-aged-care-nursing-staff-to-manage-residents-behavioural-and-psychological-symptoms-of-dementia-in-real-time-using-the-nurses-behavioural-assistant-nba-a-pilot-site-end-user-attitudes-trial
#17
Britt Klein, Lisa Clinnick, Jessica Chesler, Andrew Stranieri, Adam Bignold, Richard Dazeley, Suzanne McLaren, Sue Lauder, Venki Balasubramanian
BACKGROUND: This regional pilot site 'end-user attitudes' study explored nurses' experiences and impressions of using the Nurses' Behavioural Assistant (NBA) (a knowledge-based, interactive ehealth system) to assist them to better respond to behavioural and psychological symptoms of dementia (BPSD) and will be reported here. METHODS: Focus groups were conducted, followed by a four-week pilot site 'end-user attitudes' trial of the NBA at a regional aged care residential facility (ACRF)...
2018: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/29497377/long-term-treatment-with-low-dose-caffeine-worsens-bpsd-like-profile-in-3xtg-ad-mice-model-of-alzheimer-s-disease-and-affects-mice-with-normal-aging
#18
Raquel Baeta-Corral, Björn Johansson, Lydia Giménez-Llort
Coffee or caffeine has recently been suggested as prophylaxis for dementia. Although memory problems are hallmarks of Alzheimer's disease, this dementia is also characterized by neuropsychiatric symptoms called Behavioral and Psychological Symptoms of Dementia (BPSD). The impact of preventive/therapeutic strategies on both cognitive and non-cognitive symptoms can be addressed in the 3xTg-AD mice, since they exhibit cognitive but also BPSD-like profiles. Here, we studied the long-term effects of a low dose of caffeine in male 3xTg-AD mice and as compared to age-matched non-transgenic (NTg) counterparts with normal aging...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29485197/testing-the-evidence-integration-triangle-for-implementation-of-interventions-to-manage-behavioral-and-psychological-symptoms-associated-with-dementia-protocol-for-a-pragmatic-trial
#19
Barbara Resnick, Ann Kolanowski, Kimberly Van Haitsma, Elizabeth Galik, Marie Boltz, Jeanette Ellis, Liza Behrens, Nina M Flanagan, Karen J Eshraghi, Shijun Zhu
Behavioral and psychological symptoms of dementia (BPSD) include aggression, agitation, resistiveness to care, depression, anxiety, apathy, and hallucinations. BPSD are common in nursing home residents and can be ameliorated using person-centered approaches. Despite regulatory requirements, less than 2% of nursing homes consistently implement person-centered behavioral approaches. In a National Institute of Nursing Research-funded research protocol, we are implementing a pragmatic cluster randomized clinical trial designed to enable staff in nursing homes to reduce BPSD using behavioral approaches while optimizing function, preventing adverse events, and improving quality of life of residents...
February 27, 2018: Research in Nursing & Health
https://www.readbyqxmd.com/read/29463483/the-experience-of-paid-family-care-workers-of-people-with-dementia-in-south-korea
#20
Jungmin Kim, Anita Marie De Bellis, Lily Dongxia Xiao
PURPOSE: The South Korean government introduced the universal long-term care insurance program in 2008 that created a new employment category of "paid family-care worker" to assist the elderly with chronic illnesses including dementia. The aim of this study was to understand the lived experience of paid family-care workers of people with dementia in South Korea. METHODS: The study was a qualitative research design underpinned by interpretive description principles involving eight paid family-care workers...
March 2018: Asian Nursing Research
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