keyword
https://read.qxmd.com/read/38236117/melanoma-and-dysplastic-nevi-development-after-ranitidine-rilmenidine-%C3%B0-oxonidine-lercanidipine-rosuvastatin-and-verapamil-trandolapril-new-data-case-series-the-potential-role-of-nitrosamine-ndsris-contamination-in-polymedication-as-substantial-skin-cancer
#1
JOURNAL ARTICLE
G Tchernev, N Naydekova
The idea of drug-induced/exogenic Nitrosogenesis is driven by the possibility of prolonged exposure of the human body to the influence of nitrosamines within the drug intake - substances or contaminants that have been proven to be carcinogenic or mutagenic one.Until recently, there was a complete lack of data in the scientific literature on the relationship between cancer, polymedication and polycontamination with nitrosamines. In the last decade, melanoma has been described repeatedly in the medical literature as a possible side-effect within the intake of possibly with nitrosamines contaminated medications such as: Valsartan, Hydrochlorothiazide, Amlodipine, Nebivolol, Bisoprolol and Perindopril...
November 2023: Georgian Medical News
https://read.qxmd.com/read/36999443/efficacy-of-antihypertensive-drugs-of-different-classes-after-renal-denervation-in-spontaneously-hypertensive-rats
#2
JOURNAL ARTICLE
Mathias Hohl, Lucas Lauder, Özlem Sevimli, Mert Tokcan, Lea Wagmann, Felix Götzinger, Clara Schneider, Ulrich Hübner, Ulrike Lehnert, Markus R Meyer, Michael Böhm, Felix Mahfoud
BACKGROUND: Renal denervation (RDN) lowers blood pressure (BP) in patients with uncontrolled hypertension. Limited data exist on the effectiveness of different antihypertensive medications following RDN on BP and maladaptive cardiac phenotypes. METHODS: Eighty-nine male spontaneously hypertensive rats with continuous BP recording underwent RDN or sham operation. Ten days postsurgery, spontaneously hypertensive rats were randomized to receive no antihypertensive medication, amlodipine, olmesartan, hydrochlorothiazide, bisoprolol, doxazosin, or moxonidine for 28 days...
March 31, 2023: Hypertension
https://read.qxmd.com/read/36978098/identifying-potential-biomarkers-for-the-diagnosis-and-treatment-of-iga-nephropathy-based-on-bioinformatics-analysis
#3
JOURNAL ARTICLE
Xiaohui Li, Mengru Zeng, Jialu Liu, Shumin Zhang, Yifei Liu, Yuee Zhao, Cong Wei, Kexin Yang, Ying Huang, Lei Zhang, Li Xiao
BACKGROUND: IgA nephropathy (IgAN) has become the leading cause of end-stage renal disease in young adults. Nevertheless, the current diagnosis exclusively relies on invasive renal biopsy, and specific treatment is deficient. Thus, our study aims to identify potential crucial genes, thereby providing novel biomarkers for the diagnosis and therapy of IgAN. METHODS: Three microarray datasets were downloaded from GEO official website. Differentially expressed genes (DEGs) were identified by limma package...
March 28, 2023: BMC Medical Genomics
https://read.qxmd.com/read/36835270/moxonidine-increases-uptake-of-oxidised-low-density-lipoprotein-in-cultured-vascular-smooth-muscle-cells-and-inhibits-atherosclerosis-in-apolipoprotein-e-deficient-mice
#4
JOURNAL ARTICLE
Yutang Wang, Dinh Tam Nguyen, Jack Anesi, Ahmed Alramahi, Paul K Witting, Zhonglin Chai, Abdul Waheed Khan, Jason Kelly, Kate M Denton, Jonathan Golledge
This study aimed to investigate the effect of the sympatholytic drug moxonidine on atherosclerosis. The effects of moxonidine on oxidised low-density lipoprotein (LDL) uptake, inflammatory gene expression and cellular migration were investigated in vitro in cultured vascular smooth muscle cells (VSMCs). The effect of moxonidine on atherosclerosis was measured by examining aortic arch Sudan IV staining and quantifying the intima-to-media ratio of the left common carotid artery in apolipoprotein E-deficient (ApoE-/- ) mice infused with angiotensin II...
February 14, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/36410408/moxonidine-ameliorates-cardiac-injury-in-rats-with-metabolic-syndrome-by-regulating-autophagy
#5
JOURNAL ARTICLE
Shaimaa S El-Sayed, Samar Rezq, Amira Ebrahim Alsemeh, Mona F Mahmoud
AIMS: Reduced cardiac autophagy, ischemic injury, sympathetic overactivity, and apoptosis all contribute to metabolic syndrome (MetS)-associated cardiovascular risks. NR4A2, an orphan nuclear receptor NR4A family member, induces autophagy while suppressing apoptosis in myocardial infarction. Moxonidine, a sympathoinhibitor imidazoline1 receptor (I1R) agonist, has beneficial metabolic and hemodynamic effects; however, whether autophagy and/or NR4A2 signaling are involved in moxonidine's cardiovascular effects via I1R activation, is unknown, and is the aim of this study...
November 18, 2022: Life Sciences
https://read.qxmd.com/read/36400921/novel-non-stimulants-rescue-hyperactive-phenotype-in-an-adgrl3-1-mutant-zebrafish-model-of-adhd
#6
JOURNAL ARTICLE
Hildur Sóley Sveinsdóttir, Christian Christensen, Haraldur Þorsteinsson, Perrine Lavalou, Matthew O Parker, Alena Shkumatava, William H J Norton, Emile Andriambeloson, Stéphanie Wagner, Karl Ægir Karlsson
ADHD is a highly prevalent neurodevelopmental disorder. The first-line therapeutic for ADHD, methylphenidate, can cause serious side effects including weight loss, insomnia, and hypertension. Therefore, the development of non-stimulant-based therapeutics has been prioritized. However, many of these also cause other effects, most notably somnolence. Here, we have used a uniquely powerful genetic model and unbiased drug screen to identify novel ADHD non-stimulant therapeutics. We first found that adgrl3.1 null (adgrl3...
November 18, 2022: Neuropsychopharmacology
https://read.qxmd.com/read/36101495/the-signaling-and-selectivity-of-%C3%AE-adrenoceptor-agonists-for-the-human-%C3%AE-2a-%C3%AE-2b-and-%C3%AE-2c-adrenoceptors-and-comparison-with-human-%C3%AE-1-and-%C3%AE-adrenoceptors
#7
JOURNAL ARTICLE
Richard G W Proudman, Juliana Akinaga, Jillian G Baker
α2-adrenoceptors, (α2A, α2B and α2C-subtypes), are Gi-coupled receptors. Central activation of brain α2A and α2C-adrenoceptors is the main site for α2-agonist mediated clinical responses in hypertension, ADHD, muscle spasm and ITU management of sedation, reduction in opiate requirements, nausea and delirium. However, despite having the same Gi-potency in functional assays, some α2-agonists also stimulate Gs-responses whilst others do not. This was investigated. Agonist responses to 49 different α-agonists were studied (CRE-gene transcription, cAMP, ERK1/2-phosphorylation and binding affinity) in CHO cells stably expressing the human α2A, α2B or α2C-adrenoceptor, enabling ligand intrinsic efficacy to be determined (binding KD /Gi-IC50 )...
October 2022: Pharmacology Research & Perspectives
https://read.qxmd.com/read/36027398/cardiovascular-and-kidney-outcomes-in-treated-resistant-hypertensive-patients
#8
JOURNAL ARTICLE
Olena Matova, Larysa Mishchenko, Tatyana Talaeva
OBJECTIVE: To evaluate the incidence of cardiovascular (CV) and kidney outcomes and its predictors in treated resistant hypertensive (rHTN) patients. DESIGN AND METHOD: We studied 117 rHTN patients and 114 controlled hypertensives (cHTN) patients on a triple fixed-dose combination of RAAS blockers / CCB / thiazide or thiazide-like diuretic. Patients with rHTN treated with the same type of triple fixed-dose combination in maximally tolerated doses plus the individually defined most effective fourth-line agent (spironolactone/eplerenone 56...
June 1, 2022: Journal of Hypertension
https://read.qxmd.com/read/36027270/the-effect-of-renal-denervation-on-the-circadian-blood-pressure-pattern-in-patients-with-resistant-hypertension
#9
JOURNAL ARTICLE
Moiseeva Anna, Caraus Alexandru, Abras Marcel, Ciobanu Nicolae, Moscalu Vitalie, Surev Artiom, Cociu Maria, Caraus Mihaela, Falkovskaya Alla
OBJECTIVE: Loss of the normal circadian rhythm of blood pressure is associated with adverse cardiovascular outcomes, the activity of the sympathetic nervous system in this context having an important pathophysiological mechanism. So, the objective of the study was to evaluate the impact of sympathetic renal denervation on circadian blood pressure pattern in patients with resistant hypertension. DESIGN AND METHOD: The study included 75 patients with resistant hypertension, without comorbidities and mean age of 49...
June 1, 2022: Journal of Hypertension
https://read.qxmd.com/read/36027194/the-pharmacokinetic-parameters-data-of-the-20-most-commonly-prescribed-antihypertensive-medications
#10
JOURNAL ARTICLE
Randah Alghamdi, Fahad Muhammad, Hanad Osman, Farah Salim, Sian Jenkins, Dennis Bernieh, Henry Gill, Dan Lane, Iain Squire, Donald Jones, Pankaj Gupta
OBJECTIVE: Chemical Adherence Testing (CAT) is now the preferred method for assessing adherence with prescribed medication. Further research is needed to understand the impact of pharmacokinetics(PK) on medication detection and adherence status, but there is no readily available collated literature. This study aims to collate PK data for 20 of the most prescribed antihypertensive medications. DESIGN AND METHOD: Prescription rates were determined by reviewing CAT data of 3796 unselected hypertension patients whose samples were tested by the Department of Chemical Pathology & Metabolic Diseases, University Hospitals of Leicester NHS Trust...
June 1, 2022: Journal of Hypertension
https://read.qxmd.com/read/36027077/effect-of-coronavirus-infection-on-patients-with-controlled-and-uncontrolled-arterial-hypertension
#11
JOURNAL ARTICLE
Anastasiya Denisova, Olga Sivakova, Tatyana Solntseva, Irina Chazova
OBJECTIVE: To assess the severity of coronavirus infection in patients with hypertension, including resistantand refractory hypertension, and to assess the effect of taking ACE inhibitors and ARBs on the course of COVID-19. DESIGN AND METHOD: We called 252 people with an established diagnosis of hypertension, included in the database from November 2018 to July 2021, in order to identify patients who have recently undergone COVID-19. Initially, the patients were divided into groups depending on the number of drugs taken and the achievement of target blood pressure levels...
June 1, 2022: Journal of Hypertension
https://read.qxmd.com/read/35908005/over-prescription-of-the-imidazoline-receptor-agonists-evidence-for-restriction-of-the-therapeutic-indication
#12
JOURNAL ARTICLE
Rimas Jankūnas, Diana Rinkūnienė, Donatas Stakišaitis
BACKGROUND: Major antihypertensive drug classes (but not Imidazoline Receptor Agonists) have been demonstrated to reduce cardiovascular morbidity and mortality. In 2017, Latvia and Lithuania had the highest cardiovascular mortality among the Eastern, Central, Northern, and Western Member States of the European Union (EU). Cardiovascular mortality in Estonia is much lower than in Lithuania and Latvia. OBJECTIVE: To evaluate the consumption of Imidazoline Receptor Agonists in the Baltic States and its potential implications...
September 2022: Therapeutic Innovation & Regulatory Science
https://read.qxmd.com/read/35560792/amelioration-of-cardiac-autonomic-dysfunction-mitigates-perivascular-and-perirenal-adipose-inflammation-and-cardiorenal-involvement-in-prediabetes
#13
JOURNAL ARTICLE
Ahmed F El-Yazbi, Safaa Hammoud, Ibrahim F Alzaim, Amira F Bekdash, Nahed Mougharbil, Hana F Itani
BACKGROUND: Early metabolic impairment is associated with significant cardiorenal risk. Specifically, subtle serum insulin and lipids changes in prediabetes trigger cardioautonomic and renovascular deterioration. Interestingly, data from our laboratory suggest that these insidious alterations are triggered by perirenal and perivascular adipose inflammation in response to hypoxia evoked by a localized increase in uncoupling protein1 (UCP1) expression and activity. This affects the adjacent organs in a paracrine manner...
May 2022: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://read.qxmd.com/read/35074611/differential-effects-of-renin-angiotensine-aldosteron-system-inhibition-sympathoinhibition-and-low-sodium-diet-on-blood-pressure-in-women-with-a-history-of-preeclampsia-a-double-blind-placebo-controlled-cross-over-trial-the-palm-study
#14
RANDOMIZED CONTROLLED TRIAL
Gerbrand A Zoet, Nina D Paauw, Jan H W Veerbeek, T Katrien J Groenhof, Wilko Spiering, Marianne C Verhaar, A Franx, A Titia Lely
Current guidelines lack sufficient evidence to recommend a specific blood pressure lowering strategy to prevent cardiovascular disease after preeclampsia. We conducted a double-blind cross-over trial to identify the most potent antihypertensive strategy: renin-angiotensin-aldosterone system (RAAS) inhibition (losartan), sympathoinhibition (moxonidine), low sodium diet and placebo (n = 10). Due to low inclusion rate our study stopped prematurely. Initiatory analyses showed no significant effect of antihypertensive strategy on office blood pressure and 24-hour blood pressure...
March 2022: Pregnancy Hypertension
https://read.qxmd.com/read/34622546/assessment-of-drug-drug-interactions-between-moxonidine-and-antiepileptic-drugs-in-the-maximal-electroshock-seizure-test-in-mice
#15
JOURNAL ARTICLE
Krzysztof Łukawski, Stanisław Jerzy Czuczwar
Hypertension is a common comorbid condition with epilepsy, and drug interactions between antihypertensive and antiepileptic drugs (AEDs) are likely in patients. Experimental studies showed that centrally active imidazoline compounds belonging to antihypertensive drugs can affect seizure susceptibility. The purpose of this study was to assess the effect of moxonidine, an I1 -imidazoline receptor agonist, on the anticonvulsant efficacy of numerous AEDs (carbamazepine, phenobarbital, valproate, phenytoin, oxcarbazepine, topiramate and lamotrigine) in the mouse model of maximal electroshock...
January 2022: Basic & Clinical Pharmacology & Toxicology
https://read.qxmd.com/read/34524565/influence-of-moxonidine-and-bisoprolol-on-morphofunctional-condition-of-arterial-wall-and-telomerase-activity-in-postmenopausal-women-with-arterial-hypertension-and-osteopenia-the-results-from-a-moscow-randomized-study
#16
JOURNAL ARTICLE
E Dudinskaya, O Tkacheva, E Bazaeva, L Matchekhina, K Eruslanova, N Sharashkina, Yu Kotovskaya, V Larina
PURPOSE: To compare the effect of 12 months of treatment with moxonidine or bisoprolol on telomerase activity (TA) and parameters characterizing the arterial wall state in postmenopausal women with arterial hypertension (AH) and osteopenia. METHODS: An open-label randomized study with 114 postmenopausal women with hypertension and osteopenia; pulse wave velocity (PWV), intima-media thickness (IMT), and TA were analyzed initially and after 12 months of therapy with moxonidine (n = 57) or bisoprolol (n = 57)...
September 15, 2021: Cardiovascular Drugs and Therapy
https://read.qxmd.com/read/34346265/effect-of-menopausal-symptom-treatment-options-on-palpitations-a-systematic-review
#17
JOURNAL ARTICLE
Y Sheng, J S Carpenter, C D Elomba, J S Alwine, M Yue, C X Chen, J E Tisdale
This systematic review provides an overview of the effects of menopausal symptom treatment options on palpitations, defined as feelings of missed or exaggerated heart beats, reported by perimenopausal and postmenopausal women. Guided by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, searches were conducted in PubMed, CINAHL and PsycINFO to identify articles meeting pre-specified inclusion criteria. Of 670 unique articles identified, 37 were included in the review...
August 4, 2021: Climacteric: the Journal of the International Menopause Society
https://read.qxmd.com/read/34171957/the-use-of-moxonidine-in-the-treatment-of-arterial-hypertension
#18
JOURNAL ARTICLE
Jan Vachek
Moxonidine is an oral antihypertensive drug from the group of 2nd generation sympatholytics. In patients with mild to moderate hypertension, moxonidine lowers blood pressure (BP) as effectively as most first-line antihypertensives when used as monotherapy - if appropriate, and is also an effective adjunctive therapy in combination with other antihypertensives. It improves metabolic profile in patients with hypertension and diabetes mellitus or impaired glucose tolerance, is very well tolerated, has a low potential for drug interactions and is administered in a single daily dose...
2021: Vnitr̆ní Lékar̆ství
https://read.qxmd.com/read/34074440/the-role-of-pka-log-p-of-analytes-and-protein-matrix-in-solid-phase-extraction-using-native-and-coated-nanofibrous-and-microfibrous-polymers-prepared-via-meltblowing-and-combined-meltblowing-electrospinning-technologies
#19
JOURNAL ARTICLE
Hedvika Raabová, Jakub Erben, Jiří Chvojka, Petr Solich, František Švec, Dalibor Šatínský
Effect of physicochemical properties including dissociation constant (pKa) and partition coefficient (log P) of the compounds on their extraction efficiency in sample preparation using fibrous polymer sorbents has been demonstrated. Poly-ε-caprolactone as meltblown/electrospun composite fibers, and polypropylene, polyethylene, poly(3-hydroxybutyrate), poly(lactic acid), and polyamide 6 in the meltblown fiber format were used as sorbents in solid-phase extraction. In addition, the polycaprolactone fibers were coated with dopamine, dopamine combined with heparin, and tannin, respectively, to modify their extraction properties...
September 1, 2021: Talanta
https://read.qxmd.com/read/34054559/the-effect-of-antihypertensive-medications-on-testing-for-primary-aldosteronism
#20
REVIEW
Piotr Jędrusik, Bartosz Symonides, Jacek Lewandowski, Zbigniew Gaciong
Primary aldosteronism (PA) is a potentially curable form of secondary hypertension caused by excessive renin-independent aldosterone secretion, leading to increased target organ damage and cardiovascular morbidity and mortality. The diagnosis of PA requires measuring renin and aldosterone to calculate the aldosterone-to-renin ratio, followed by confirmatory tests to demonstrate renin-independent aldosterone secretion and/or PA subtype differentiation. Various antihypertensive drug classes interfere with the renin-angiotensin-aldosterone axis and hence evaluation for PA should ideally be performed off-drugs...
2021: Frontiers in Pharmacology
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