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Remission depression

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https://www.readbyqxmd.com/read/27901522/the-effect-of-remission-status-on-work-functioning-in-employed-patients-treated-for-major-depressive-disorder
#1
David Sarfati, Kurtis Stewart, Cindy Woo, Sagar V Parikh, Lakshmi N Yatham, Raymond W Lam
BACKGROUND: The ability to function at work is impaired in patients with major depressive disorder (MDD) but few clinical trials include occupational outcome assessments. This study examined whether symptom remission following treatment for MDD is associated with work functioning improvement. METHODS: We conducted a secondary analysis of a 12-week randomized clinical trial comparing escitalopram with or without telephone-administered cognitive therapy in employed patients with MDD (N = 86)...
November 1, 2016: Annals of Clinical Psychiatry: Official Journal of the American Academy of Clinical Psychiatrists
https://www.readbyqxmd.com/read/27894036/efficacy-of-an-adjunctive-brief-psychodynamic-psychotherapy-to-usual-inpatient-treatment-of-depression-results-of-a-randomized-controlled-trial
#2
Yves de Roten, Gilles Ambresin, Fabrice Herrera, Sylfa Fassassi, Nicolas Fournier, Martin Preisig, Jean-Nicolas Despland
BACKGROUND: For severe and chronic depression, inpatient treatment may be necessary. Current guidelines recommend combined psychological and pharmacological treatments for moderate to severe depression. Results for positive effects of combined treatment for depressed inpatients are still ambiguous. METHODS: This randomised controlled trial examined the efficacy of adding an intensive and brief psychodynamic psychotherapy (IBPP) to treatment-as-usual (TAU) for inpatients with DSM-IV major depressive episode...
November 17, 2016: Journal of Affective Disorders
https://www.readbyqxmd.com/read/27893032/effect-of-group-vs-individual-cognitive-processing-therapy-in-active-duty-military-seeking-treatment-for-posttraumatic-stress-disorder-a-randomized-clinical-trial
#3
Patricia A Resick, Jennifer Schuster Wachen, Katherine A Dondanville, Kristi E Pruiksma, Jeffrey S Yarvis, Alan L Peterson, Jim Mintz, Elisa V Borah, Antoinette Brundige, Elizabeth A Hembree, Brett T Litz, John D Roache, Stacey Young-McCaughan
Importance: Cognitive processing therapy (CPT), an evidence-based treatment for posttraumatic stress disorder (PTSD), has not been tested as an individual treatment among active-duty military. Group CPT may be an efficient way to deliver treatment. Objective: To determine the effects of CPT on PTSD and co-occurring symptoms and whether they differ when administered in an individual or a group format. Design, Setting, and Participants: In this randomized clinical trial, 268 active-duty servicemembers consented to assessment at an army medical center from March 8, 2012, to September 23, 2014, and were randomized to group or individual CPT...
November 23, 2016: JAMA Psychiatry
https://www.readbyqxmd.com/read/27888965/effects-of-nursing-interventions-on-depression-of-patients-with-rheumatoid-arthritis-a-meta-analysis-of-randomized-controlled-trials
#4
Biyun Zhou, Guohong Li, Yuqun Zhang, Zihan Zhao
INTRODUCTION: Previous randomized controlled trials have led to conflicting findings regarding the effects of nursing interventions on depression of patients with rheumatoid arthritis (RA). The purpose of this study was to use the meta-analytic approach to resolve these discrepancies. METHODS: We performed a systematic search of publications using MEDLINE, EMBASE, the Cochrane Library, and manual searches without language restrictions. Studies that met the following criteria were included: (1) randomized controlled trials; (2) duration of intervention≥4 weeks; (3) comparative control group; (4) adults with RA; (5) published studies in any language since reception; and (6) psychological symptoms assessed...
December 2016: Archives of Psychiatric Nursing
https://www.readbyqxmd.com/read/27888525/breaking-sad-unleashing-the-breakthrough-potential-of-ketamine-s-rapid-antidepressant-effects
#5
David Feifel
Preclinical Research The surprising results of a small clinical trial on the effects of low dose ketamine, a 65-year old anesthetic drug that is also used off-label for chronic pain and recreationally as a club drug, in eight depressed subjects unleashed the most significant advance in antidepressant drug development in decades. That study and subsequent ones have demonstrated that low dose, infused ketamine is able to induce a remission of depression in patients who have failed conventional medications, within 24 h...
November 26, 2016: Drug Development Research
https://www.readbyqxmd.com/read/27886569/effects-of-a-right-unilateral-ultrabrief-pulse-electroconvulsive-therapy-course-on-health-related-quality-of-life-in-elderly-depressed-patients
#6
W Vaughn McCall, Sarah H Lisanby, Peter B Rosenquist, Mary Dooley, Mustafa M Husain, Rebecca G Knapp, Georgios Petrides, Matthew V Rudorfer, Robert C Young, Shawn M McClintock, Martina Mueller, Joan Prudic, Robert M Greenberg, Richard D Weiner, Samuel H Bailine, Mary Anne Riley, Laryssa McCloud, Charles H Kellner
INTRODUCTION: Patients with Major Depressive Disorder (MDD) referred for electroconvulsive therapy (ECT) have poorer Health Related Quality of Life (HRQOL), compared with other patients with MDD, but ECT is associated with significant and durable improvement in HRQOL. However, no prior research has focused exclusively on elderly patients with MDD receiving ECT. METHODS: HRQOL data from 240 depressed patients over the age of 60 was measured with the Medical Outcomes Study Short Form 36 (SF-36)...
November 11, 2016: Journal of Affective Disorders
https://www.readbyqxmd.com/read/27883963/hypothalamic-pituitary-adrenal-axis-activity-and-cognition-in-major-depression-the-role-of-remission-status
#7
Neus Salvat-Pujol, Javier Labad, Mikel Urretavizcaya, Aida de Arriba-Arnau, Cinto Segalàs, Eva Real, Alex Ferrer, José M Crespo, Susana Jiménez-Murcia, Carles Soriano-Mas, José M Menchón, Virginia Soria
OBJECTIVES: Neuropsychological deficits and hypothalamic-pituitary-adrenal (HPA) axis dysfunction have been described in major depressive disorder (MDD). We conducted an exploratory study to investigate the role of remission status in the relationship between HPA axis and cognition in MDD. METHODS: Ninety-seven MDD patients (44 remitted, 53 non-remitted) and 97 healthy controls (HC) were evaluated. We measured verbal and visual memory, working memory, processing speed, attention, and executive function...
November 10, 2016: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/27881072/patients-with-longstanding-ulcerative-colitis-in-remission-do-not-have-more-irritable-bowel-syndrome-like-symptoms-than-controls
#8
D Lundgren, J Rutegård, V Eklöf, R Palmqvist, P Karling
BACKGROUND: Irritable bowel syndrome (IBS) is more common in patients with ulcerative colitis (UC) than expected. The prevalence of IBS in patients with UC with longstanding disease is not known. We investigated the prevalence of IBS-like symptoms in patients with UC in remission and longstanding disease in comparison to control subjects. METHODS: Sixty-eight patients with UC and 33 patients with hereditary familiar colon cancer and who underwent colonoscopy surveillance were included...
November 24, 2016: BMC Gastroenterology
https://www.readbyqxmd.com/read/27880789/targeting-ruminative-thinking-in-adolescents-at-risk-for-depressive-relapse-rumination-focused-cognitive-behavior-therapy-in-a-pilot-randomized-controlled-trial-with-resting-state-fmri
#9
Rachel H Jacobs, Edward R Watkins, Amy T Peters, Claudia G Feldhaus, Alyssa Barba, Julie Carbray, Scott A Langenecker
: This pilot randomized control trial was designed to examine whether Rumination-Focused Cognitive Behavior Therapy (RFCBT) reduces rumination and residual depressive symptoms among adolescents with a history of Major Depressive Disorder (MDD) who are at risk for relapse. We also examined whether these changes in symptoms were associated with changes in functional connectivity of the posterior cingulate cortex (PCC), a key node in the default mode network (DMN). Thirty-three adolescents (ages 12-18) were randomized to eight weeks of RFCBT or an assessment only (AO) control...
2016: PloS One
https://www.readbyqxmd.com/read/27869986/physical-exercise-for-late-life-depression-customizing-an-intervention-for-primary-care
#10
Stamatula Zanetidou, Martino Belvederi Murri, Marco Menchetti, Giulio Toni, Fabrizio Asioli, Luigi Bagnoli, Donato Zocchi, Matteo Siena, Barbara Assirelli, Claudia Luciano, Mattia Masotti, Carlo Spezia, Monica Magagnoli, Mirco Neri, Mario Amore, Klea D Bertakis
OBJECTIVES: To identify which individual- and context-related factors influence the translation into clinical practice of interventions based on physical exercise (PE) as an adjunct to antidepressants (AD) for the treatment of late-life major depression (LLMD). DESIGN: Secondary analysis of a randomized controlled trial. SETTING: Primary care with psychiatric consultation-liaison programs (PCLPs)-organizational protocols that regulate the clinical management of individuals with psychiatric disorders...
November 21, 2016: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/27869048/efficacy-safety-and-tolerability-of-vortioxetine-for-the-treatment-of-major-depressive-disorder-in-patients-aged-55-years-or-older
#11
George G Nomikos, Dapo Tomori, Wei Zhong, John Affinito, William Palo
OBJECTIVE: These post hoc analyses evaluate the efficacy, safety, and tolerability of vortioxetine versus placebo in patients aged ≥55 years with major depressive disorder (MDD). METHODS: Study-level efficacy data from 12 short-term, fixed-dose, randomized, placebo-controlled trials of vortioxetine 5-20 mg/day were assessed using a random-effects meta-analysis. Adverse events (AEs), vital signs, ECG values, liver enzymes, and body weight were pooled from the same studies...
November 21, 2016: CNS Spectrums
https://www.readbyqxmd.com/read/27863710/predictors-of-remission-from-generalized-anxiety-disorder-and-major-depressive-disorder
#12
Kristen M Kelly, Briana Mezuk
BACKGROUND: The predictors of onset of major depressive disorder (MDD) and generalized anxiety disorder (GAD) are well-characterized. However the factors that predict remission from these conditions are less clear, and the study of this area is further complicated by differing definitions of remission. METHODS: Data come from the National Comorbidity Survey - Replication, and analysis was limited to respondents with a lifetime history of GAD (n=621) or MDD (n=1299) assessed by the Composite International Diagnostic Interview...
October 26, 2016: Journal of Affective Disorders
https://www.readbyqxmd.com/read/27859669/effectiveness-of-agomelatine-on-anhedonia-in-depressed-patients-an-outpatient-open-label-real-world-study
#13
Pedro Damian Gargoloff, Ricardo Corral, Luis Herbst, Miguel Marquez, Giovanni Martinotti, Pedro Rafael Gargoloff
OBJECTIVE: The aim of this real-world study was to evaluate the effect of agomelatine on anhedonia as primary endpoint in outpatients under treatment of major depressive episodes. METHODS: The study was an open-label, multicenter, 8-week phase IV trial. Two hundred fifty-seven (257) patients were recruited, and 143 patients were included in the analysis. Agomelatine was administered orally as a 25-mg tablet. The dose could be increased to 50 mg after 2 weeks of treatment...
November 2016: Human Psychopharmacology
https://www.readbyqxmd.com/read/27855769/-cognitive-impairment-after-depression-leads-to-disability
#14
Anja Friis Elliott, Morten Dvoracek Hell, Abigail Sheldrick-Michel, Bent Nielsen
Cognitive impairment plays a crucial role in the course of depression and often persists after remission, which leads to considerable socio-occupational disability. In detecting cognitive deficits, the Danish translation of the Screen for Cognitive Impairment in Psychiatry has proven useful. No current pharmacotherapy has been approved for treating cognitive dysfunction in depression, but selective serotonin reuptake inhibitors may have beneficial effects. Cognitive computer training and psychoeducation are promising in the treatment of cognitive impairment associated with depression...
November 7, 2016: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/27852961/effect-of-antipsychotic-pharmacotherapy-on-clinical-outcomes-of-intermittent-theta-burst-stimulation-for-refractory-depression
#15
Laura Schulze, Gary Remington, Peter Giacobbe, Sidney H Kennedy, Daniel M Blumberger, Zafiris J Daskalakis, Jonathan Downar
Theta-burst stimulation is an emerging protocol for repetitive transcranial magnetic stimulation that takes 1-3 min to administer, yet offers equal/superior potency to conventional protocols lasting 30-60 min. However, preclinical evidence suggests that D2 receptor blockade may abolish the acute effects of theta-burst stimulation on synaptic facilitation or inhibition. As many patients presenting for repetitive transcranial magnetic stimulation are taking antipsychotic medications as augmentation for treatment-resistant depression, this finding is potentially concerning for the implementation of theta-burst stimulation in clinical settings...
November 9, 2016: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/27847932/neurochemical-alterations-in-anterior-cingulate-cortex-in-bipolar-disorder-a-proton-magnetic-resonance-spectroscopy-study-1h-mrs
#16
Beata Galińska-Skok, Beata Konarzewska, Bożena Kubas, Eugeniusz Tarasów, Agata Szulc
OBJECTIVES: The aim of this study was to determine neurochemical alterations in bipolar disorder using proton magnetic resonance spectroscopy (1H-MRS). METHODS: We investigated a group of 27 patients diagnosed with bipolar disorder (with manic and mixed episodes, depression and after remission of symptoms) and 10 healthy subjects. MR imaging and 1H-MRS were performed on a 1.5 T scanner. Voxels of 8 cm3 were positioned in the anterior cingulate, left frontal lobe and left temporal lobe...
2016: Psychiatria Polska
https://www.readbyqxmd.com/read/27846292/implicit-and-explicit-self-esteem-in-current-remitted-recovered-and-comorbid-depression-and-anxiety-disorders-the-nesda-study
#17
Lonneke A van Tuijl, Klaske A Glashouwer, Claudi L H Bockting, Jorge N Tendeiro, Brenda W J H Penninx, Peter J de Jong
BACKGROUND: Dual processing models of psychopathology emphasize the relevance of differentiating between deliberative self-evaluative processes (explicit self-esteem; ESE) and automatically-elicited affective self-associations (implicit self-esteem; ISE). It has been proposed that both low ESE and ISE would be involved in major depressive disorder (MDD) and anxiety disorders (AD). Further, it has been hypothesized that MDD and AD may result in a low ISE "scar" that may contribute to recurrence after remission...
2016: PloS One
https://www.readbyqxmd.com/read/27845776/proliferation-rates-and-gene-expression-profiles-in-human-lymphoblastoid-cell-lines-from-patients-with-depression-characterized-in-response-to-antidepressant-drug-therapy
#18
J Breitfeld, C Scholl, M Steffens, K Brandenburg, K Probst-Schendzielorz, O Efimkina, D Gurwitz, M Ising, F Holsboer, S Lucae, J C Stingl
The current therapy success of depressive disorders remains in need of improvement due to low response rates and a delay in symptomatic improvement. Reliable functional biomarkers would be necessary to predict the individual treatment outcome. On the basis of the neurotrophic hypothesis of antidepressant's action, effects of antidepressant drugs on proliferation may serve as tentative individual markers for treatment efficacy. We studied individual differences in antidepressant drug effects on cell proliferation and gene expression in lymphoblastoid cell lines (LCLs) derived from patients treated for depression with documented clinical treatment outcome...
November 15, 2016: Translational Psychiatry
https://www.readbyqxmd.com/read/27843321/efficacy-of-ketamine-in-the-rapid-treatment-of-major-depressive-disorder-a-meta-analysis-of-randomized-double-blind-placebo-controlled-studies
#19
Yu Han, Jianjun Chen, Dezhi Zou, Peng Zheng, Qi Li, Haiyang Wang, Pengfei Li, Xinyu Zhou, Yuqing Zhang, Yiyun Liu, Peng Xie
BACKGROUND: An increasing number of studies are reporting that ketamine could be treated as a novel antidepressant for major depressive disorder (MDD). Therefore, we performed this meta-analysis to comprehensively and systematically assess the efficacy of ketamine for treating patients with MDD. METHOD: Randomized, double-blind, placebo-controlled studies on ketamine versus placebo for treating MDD were searched up to April 2016 in medical databases (PubMed, CCTR, Web of Science, Embase, CBM-disc, and CNKI)...
2016: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/27837572/clinical-and-cognitive-factors-affecting-psychosocial-functioning-in-remitted-patients-with-bipolar-disorder
#20
G Konstantakopoulos, N Ioannidi, M Typaldou, D Sakkas, P Oulis
Impaired interpersonal, social, and occupational functioning is very often observed in patients with bipolar disorder, not only at the acute stages of the illness but in remission as well. This finding raises the question of multiple factors that might affect psychosocial functioning in bipolar patients, such as residual subsyndromal symptoms and neuropsychological deficits. Social cognition impairment, especially impaired Theory of Mind (ToM), might also play an important role in bipolar patients' every-day functioning, similarly to what was found in patients with schizophrenia...
July 2016: Psychiatrikē, Psychiatriki
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