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Remission depression

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https://www.readbyqxmd.com/read/29146474/a-systematic-review-and-meta-analysis-of-deep-brain-stimulation-in-treatment-resistant-depression
#1
Chanjuan Zhou, Hanping Zhang, Yinhua Qin, Tian Tian, Bing Xu, Jianjun Chen, Xinyu Zhou, Li Zeng, Liang Fang, Xunzhong Qi, Bin Lian, Haiyang Wang, Zicheng Hu, Peng Xie
BACKGROUND: Deep brain stimulation (DBS) has been applied in treatment-resistant depression (TRD) as a putative intervention targeting different brain regions. However, the antidepressant effects of DBS for TRD in recent clinical trials remain controversial. METHODS: We searched Scopus, EMBASE, the Cochrane Library, PubMed, and PsycINFO for all published studies investigating the efficacy of DBS in TRD up to Feb 2017. Hamilton depression rating scale (HDRS) scores and Montgomery-Asberg depression rating scale (MARDS) scores were compared between baseline levels and those after DBS using the standardized mean difference (SMD) with 95% confidence intervals (CIs)...
November 13, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29145820/demographic-and-need-factors-of-early-delayed-and-no-mental-health-care-use-in-major-depression-a-prospective-study
#2
A M Boerema, M Ten Have, A Kleiboer, R de Graaf, J Nuyen, P Cuijpers, A T F Beekman
BACKGROUND: Despite the availability of evidence based treatments, many people with major depression receive no or delayed professional treatment, which may put them at risk for adverse outcomes. The aim of this study was to examine which demographic and need factors distinguish early, delayed and no treatment use. METHODS: Data were obtained from the Netherlands Mental Health Survey and Incidence Study-2 (NEMESIS-2). People with a diagnosis of major depression in the past 12 months were included (N = 434)...
November 16, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/29145077/stability-of-the-diagnosis-of-seasonal-affective-disorder-in-a-long-term-prospective-study
#3
Marie-Laure Cléry-Melin, Philip Gorwood, Serge Friedman, Christian Even
BACKGROUND: Seasonal affective disorder (SAD) is mainly characterized by a seasonal pattern of depressive recurrences over the years. However, few studies have been conducted on the long-term course of patients with SAD, whose findings raised questions about the diagnosis stability over time. This study aimed to better characterize the diagnosis evolution, and determine prognosis markers. METHODS: An initial cohort of 225 outpatients diagnosed as having a SAD, was assessed at baseline (T1) for clinical symptoms and response to bright light therapy...
November 7, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29143534/decreased-activation-and-subsyndromal-manic-symptoms-predict-lower-remission-rates-in-bipolar-depression
#4
Marco Antonio Caldieraro, Samantha Walsh, Thilo Deckersbach, William V Bobo, Keming Gao, Terence A Ketter, Richard C Shelton, Noreen A Reilly-Harrington, Mauricio Tohen, Joseph R Calabrese, Michael E Thase, James H Kocsis, Louisa G Sylvia, Andrew A Nierenberg
OBJECTIVE: Activation encompasses energy and activity and is a central feature of bipolar disorder. However, the impact of activation on treatment response of bipolar depression requires further exploration. The aims of this study were to assess the association of decreased activation and sustained remission in bipolar depression and test for factors that could affect this association. METHODS: We assessed participants with Diagnostic and Statistical Manual of Mental Disorders (4th ed) bipolar depression ( n = 303) included in a comparative effectiveness study of lithium- and quetiapine-based treatments (the Bipolar CHOICE study)...
November 1, 2017: Australian and New Zealand Journal of Psychiatry
https://www.readbyqxmd.com/read/29143405/cost-effectiveness-modeling-of-repetitive-transcranial-magnetic-stimulation-compared-to-electroconvulsive-therapy-for-treatment-resistant-depression-in-singapore
#5
Ying Jiao Zhao, Phern Chern Tor, Ai Leng Khoo, Monica Teng, Boon Peng Lim, Yee Ming Mok
BACKGROUND: Compared to electroconvulsive therapy (ECT), the cost-effectiveness of repetitive transcranial magnetic stimulation (rTMS) in the management of treatment-resistant depression (TRD) remains unclear. OBJECTIVE/HYPOTHESIS: This study evaluated the cost-effectiveness of rTMS vs. ECT for TRD from Singapore societal perspective. METHODS: We constructed a Markov model to project the cost and benefit of rTMS compared with ECT over one year in patients with TRD...
November 16, 2017: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/29135294/-study-of-socio-demographic-factors-in-the-treatment-of-unipolar-major-depression-in-a-follow-up-clinical-trial
#6
Melinda Ferencz, Sándor Csibi, József Gabos Grecu
INTRODUCTION: Depression is one of the most widespread illnesses of our time, currently affecting more than 300 million people worldwide. Literature identifies several socio-demographic risk factors in the development of the depression. AIM: We aim to examine the socio-demographic factors involved in the remission of clinically diagnosed unipolar major depression. METHOD: Data collection was performed during 2016, at the 1st Psychiatric Clinic from Tirgu Mures...
October 2017: Orvosi Hetilap
https://www.readbyqxmd.com/read/29134965/depression-is-associated-with-more-aggressive-inflammatory-bowel-disease
#7
Bharati Kochar, Edward L Barnes, Millie D Long, Kelly C Cushing, Joseph Galanko, Christopher F Martin, Laura E Raffals, Robert S Sandler
OBJECTIVES: Depression is prevalent in inflammatory bowel disease (IBD) patients. The impact of depression on IBD is not well-studied. It is unknown how providers should assess depression. METHODS: We used data from the Sinai-Helmsley Alliance for Research Excellence cohort, to assess methods of diagnosing depression and effects of baseline depression on disease activity at follow-up. A patient health questionnaire (PHQ-8) score ≥5 was consistent with mild depression...
November 14, 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/29133948/increased-hippocampal-tail-volume-predicts-depression-status-and-remission-to-anti-depressant-medications-in-major-depression
#8
J J Maller, K Broadhouse, A J Rush, E Gordon, S Koslow, S M Grieve
Studies of patients with major depressive disorder (MDD) have consistently reported reduced hippocampal volumes; however, the exact pattern of these volume changes in specific anatomical subfields and their functional significance is unclear. We sought to clarify the relationship between hippocampal tail volumes and (i) a diagnosis of MDD, and (ii) clinical remission to anti-depressant medications (ADMs). Outpatients with nonpsychotic MDD (n=202) based on DSM-IV criteria and a 17-item Hamilton Rating Scale for Depression (HRSD17) score ⩾16 underwent pretreatment magnetic resonance imaging as part of the international Study to Predict Optimized Treatment for Depression (iSPOT-D)...
November 14, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/29129610/the-effect-of-rat-strain-and-stress-exposure-on-performance-in-touchscreen-tasks
#9
Lena-Sophie Martis, Simone Krog, Thao Phuong Tran, Elena Bouzinova, Sofie Laage Christiansen, Arne Møller, Megan C Holmes, Ove Wiborg
Patients suffering from depression-associated cognitive impairments often recover incompletely after remission from the core symptoms of depression (lack of energy, depressed mood and anhedonia). This study aimed to set the basis for clinically relevant testing of cognitive impairments in a preclinical model of depression. Hence, we used the chronic mild stress (CMS) model of depression, which provokes the core symptom of anhedonia in a fraction of the stress exposed animals, while others remain resilient, and assessed the entire CMS groups' cognitive performance on the touchscreen operant platform...
November 9, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/29127813/the-effectiveness-of-culturally-sensitive-collaborative-treatment-of-depressed-chinese-in-family-medicine-clinics-a-randomized-controlled-trial
#10
Hui-Chun Huang, Shen-Ing Liu, Lee-Ching Hwang, Fang-Ju Sun, Jin-Jin Tjung, Chiu-Ron Huang, Tsai-Chung Li, Yo-Ping Huang, Albert Yeung
OBJECTIVE: To investigate whether the Culturally Sensitive Collaborative Treatment (CSCT) would improve outcomes for patients with major depression who were managed in family medicine clinics in Taiwan. METHOD: A single-blinded randomized trial was conducted in 26 family medicine clinics. Patients with major depressive disorder were consecutively randomized to either CSCT or treatment as usual (TAU). The primary outcome was the severity of depression. Secondary outcomes included treatment response, treatment remission, quality of life, and medication adherence...
October 10, 2017: General Hospital Psychiatry
https://www.readbyqxmd.com/read/29119301/whole-body-vibration-added-to-treatment-as-usual-is-effective-in-adolescents-with-depression-a-partly-randomized-three-armed-clinical-trial-in-inpatients
#11
Heidrun Lioba Wunram, Stefanie Hamacher, Martin Hellmich, Maxi Volk, Franziska Jänicke, Franziska Reinhard, Wilhelm Bloch, Philipp Zimmer, Christine Graf, Eckhard Schönau, Gerd Lehmkuhl, Stephan Bender, Oliver Fricke
There is growing evidence for the effectiveness of exercise in the treatment of adult major depression. With regard to adolescents, clinical trials are scarce. Due to the inherent symptoms of depression (lack of energy, low motivation to exercise), endurance training forms could be too demanding especially in the first weeks of treatment. We hypothesized that an easy-to-perform passive muscular training on a whole body vibration (WBV) device has equal anti-depressive effects compared to a cardiovascular training, both administered as add-ons to treatment as usual (TAU)...
November 8, 2017: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/29119217/psilocybin-with-psychological-support-for-treatment-resistant-depression-six-month-follow-up
#12
R L Carhart-Harris, M Bolstridge, C M J Day, J Rucker, R Watts, D E Erritzoe, M Kaelen, B Giribaldi, M Bloomfield, S Pilling, J A Rickard, B Forbes, A Feilding, D Taylor, H V Curran, D J Nutt
RATIONALE: Recent clinical trials are reporting marked improvements in mental health outcomes with psychedelic drug-assisted psychotherapy. OBJECTIVES: Here, we report on safety and efficacy outcomes for up to 6 months in an open-label trial of psilocybin for treatment-resistant depression. METHODS: Twenty patients (six females) with (mostly) severe, unipolar, treatment-resistant major depression received two oral doses of psilocybin (10 and 25 mg, 7 days apart) in a supportive setting...
November 8, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/29116947/cerebrovascular-steal-phenomenon-and-electroconvulsive-therapy-a-case-report-and-review-of-the-literature
#13
Ana Hategan, Calvin H Hirsch
Electroconvulsive therapy (ECT) is a safe and effective treatment for major depressive disorder, but cerebrovascular and cardiovascular complications, although rare, remain the most concerning. This is particularly notable in those with preexisting cerebrovascular disease, which impacts dynamic cerebral autoregulation. In these patients, the increased blood flow to the seizing portions of the brain induced by ECT potentially can reduce cerebral blood flow to ischemic areas, possibly causing adverse neurological events...
November 8, 2017: Journal of ECT
https://www.readbyqxmd.com/read/29110183/integrated-cross-network-connectivity-of-amygdala-insula-and-subgenual-cingulate-associated-with-facial-emotion-perception-in-healthy-controls-and-remitted-major-depressive-disorder
#14
Lisanne M Jenkins, Jonathan P Stange, Alyssa Barba, Sophie R DelDonno, Leah R Kling, Emily M Briceño, Sara L Weisenbach, K Luan Phan, Stewart A Shankman, Robert C Welsh, Scott A Langenecker
Emotion perception deficits could be due to disrupted connectivity of key nodes in the salience and emotion network (SEN), including the amygdala, subgenual anterior cingulate cortex (sgACC), and insula. We examined SEN resting-state (rs-)fMRI connectivity in rMDD in relation to Facial Emotion Perception Test (FEPT) performance. Fifty-two medication-free people ages 18 to 23 years participated. Twenty-seven had major depressive disorder (MDD) in remission (rMDD, 10 males), as MDD is associated with emotion perception deficits and alterations in rsfMRI...
November 6, 2017: Cognitive, Affective & Behavioral Neuroscience
https://www.readbyqxmd.com/read/29110140/economic-evaluation-of-implementing-a-novel-pharmacogenomic-test-idgenetix-%C3%A2-to-guide-treatment-of-patients-with-depression-and-or-anxiety
#15
Mehdi Najafzadeh, Jorge A Garces, Alejandra Maciel
BACKGROUND: The response to therapeutics varies widely in patients with depression and anxiety, making selection of an optimal treatment choice challenging. IDgenetix(®), a novel pharmacogenomic test, has been shown to improve outcomes by predicting the likelihood of response to different psychotherapeutic medications. OBJECTIVE: The objective of this study was to estimate the cost effectiveness of implementing a novel pharmacogenomic test (IDgenetix(®)) to guide treatment choices in patients with depression and/or anxiety compared with treatment as usual from the US societal perspective...
November 6, 2017: PharmacoEconomics
https://www.readbyqxmd.com/read/29109690/comorbid-mental-disorders-and-6-month-symptomatic-and-functioning-outcomes-in-chinese-university-students-at-clinical-high-risk-for-psychosis
#16
Jingyu Shi, Lu Wang, Yuhong Yao, Na Su, Chenyu Zhan, Ziyu Mao, Xudong Zhao
Background: High rates of non-psychotic psychopathological symptoms have been observed in clinical population at clinical high risk (CHR) for psychosis. These comorbid disorders affected the baseline functional level of CHR patients. However, little is known about the comorbid mental disorder in CHR individuals in non-clinical adolescent population. This study aimed to investigate the comorbid mental disorder in non-clinical CHR adolescents and the impact on attenuated psychosis symptoms (APS) as well as clinical outcome...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29105003/anxiety-irritability-and-agitation-as-indicators-of-bipolar-mania-with-depressive-symptoms-a-post-hoc-analysis-of-two-clinical-trials
#17
Trisha Suppes, Jonas Eberhard, Ole Lemming, Allan H Young, Roger S McIntyre
BACKGROUND: Symptoms of anxiety, irritability, and agitation (AIA) are prevalent among patients with bipolar I disorder (BD-I) mania with depressive symptoms, and could potentially be used to aid physicians in the identification of this more severe form of BD-I. Using data from two clinical trials, the aims of this post hoc analysis were to describe the phenomenology of bipolar mania in terms of AIA and depressive symptoms, and to evaluate the influence of these symptoms on the likelihood of remission during treatment...
November 6, 2017: International Journal of Bipolar Disorders
https://www.readbyqxmd.com/read/29102368/-body-dysmorphic-disorder-future-prospects-of-medical-care
#18
E Siegfried, A Ayrolles, H Rahioui
Body dysmorphic disorder (BDD) is characterized by excessive preoccupation with a slight or imagined defect in one's physical appearance, believing they look ugly, abnormal or deformed. While the most common preoccupations focus on the skin, hair and nose, any part of the body may be involved. Preoccupations are intrusive, time-consuming and hard to control. Repetitive behaviors are performed in response to the preoccupations. BDD is associated with marked impairment in socio-professional functioning, poor quality of life and high suicide rates...
November 1, 2017: L'Encéphale
https://www.readbyqxmd.com/read/29100154/oxytocin-plasma-levels-predict-the-outcome-of-psychotherapy-a-pilot-study-in-chronic-depression
#19
A Jobst, L Sabaß, D Hall, B Brücklmeier, A Buchheim, J Hall, N Sarubin, P Zill, P Falkai, E-L Brakemeier, F Padberg
BACKGROUND: Oxytocin is associated with bonding and social deficits in psychiatric disorders and has also been discussed as a potential therapeutic intervention to augment psychotherapy. The Cognitive Behavioral Analysis System of Psychotherapy (CBASP) is a specific form of psychotherapy for chronic depression, an illness in which interpersonal deficits play a major role. In this pilot study, we investigated whether Oxytocin plasma levels predict the clinical outcome of chronic depressive patients after CBASP...
October 24, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29100149/predictors-of-treatment-outcome-in-depression-in-later-life-a-systematic-review-and-meta-analysis
#20
REVIEW
Chavit Tunvirachaisakul, Rebecca L Gould, Mark C Coulson, Emma V Ward, Gemma Reynolds, Rebecca L Gathercole, Hannah Grocott, Thitiporn Supasitthumrong, Athicha Tunvirachaisakul, Kate Kimona, Robert J Howard
BACKGROUND: Predictor analyses of late-life depression can be used to identify variables associated with outcomes of treatments, and hence ways of tailoring specific treatments to patients. The aim of this review was to systematically identify, review and meta-analyse predictors of outcomes of any type of treatment for late-life depression. METHODS: Pubmed, Embase, CINAHL, Web of Science and PsycINFO were searched for studies published up to December 2016. Primary and secondary studies reported treatment predictors from randomised controlled trials of any treatment for patients with major depressive disorder aged over 60 were included...
October 10, 2017: Journal of Affective Disorders
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