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https://www.readbyqxmd.com/read/29774005/the-bergen-4-day-ocd-treatment-delivered-in-a-group-setting-12-month-follow-up
#1
Bjarne Hansen, Kristen Hagen, Lars-Göran Öst, Stian Solem, Gerd Kvale
The Bergen 4-day concentrated exposure treatment (cET) for obsessive-compulsive disorder (OCD) has proven highly acceptable; with practically no drop-out and a 6 month remission rate of nearly 70%. The aim of the present study was to evaluate long term gains of the approach, and to compare the results to findings from our recent meta-analysis. Sixty-nine of 95 patients consecutively referred to an outpatient clinic in the specialist health care, were offered the Bergen 4-day treatment. Among the 65 who initiated treatment, 60...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/29769159/empirical-evidence-for-definitions-of-episode-remission-recovery-relapse-and-recurrence-in-depression-a-systematic-review
#2
P L de Zwart, B F Jeronimus, P de Jonge
AIMS: For the past quarter of a century, Frank et al.'s (1991) consensus-based definitions of major depressive disorder (MDD) episode, remission, recovery, relapse and recurrence have been the paramount driving forces for consistency in MDD research as well as in clinical practice. This study aims to review the evidence for the empirical validation of Frank et al.'s proposed concept definitions and to discuss evidence-based modifications. METHODS: A literature search of Web of Science and PubMed from 1/1/1991 to 08/30/2017 identified all publications which referenced Frank et al...
May 17, 2018: Epidemiology and Psychiatric Sciences
https://www.readbyqxmd.com/read/29768955/results-of-a-real-world-study-on-vortioxetine-in-patients-with-major-depressive-disorder-in-south-east-asia-revida
#3
Cheuk Ngen Chin, Azhar Zain, Solaphat Hemrungrojn, Eng Khean Ung, Patanon Kwansanit, Koon Choong Au Yong, Marvin Swee Woon Chong, Chalowat Inpa, Teck Hoe Yen, Boon Beng David Yeoh, Liam Kai Tay, Carmina Bernardo, Lionel Chee-Chong Lim, Chin Hong Yap, Calvin Fones, Ashwini Nayak, Lars Nelleman
OBJECTIVE: The REVIDA study aimed to assess the evolution of major depression symptoms in South East Asian (SEA) patients treated with vortioxetine for major depression in real-world clinical practice. METHODS: This non-interventional study was conducted from Aug 2016 to Apr 2017. A total of 138 patients (aged 18-65 years) with an active episode of major depression were recruited from Malaysia, Philippines, Singapore, and Thailand. Vortioxetine was initiated on the first visit and patients were followed for 3 months...
May 17, 2018: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/29765205/patterns-of-persistence-with-pharmacological-treatment-among-patients-with-current-depressive-episode-and-their-impact-on-long-term-outcome-a-naturalistic-study-with-5-year-follow-up
#4
Kanglai Li, Jiong Tao, Yuemei Li, Minhua Chen, Xiuhua Wu, Yingtao Liao, Xiaolan Lin, Zhaoyu Gan
Background: The aim of the study was to describe and compare the patterns of medication persistence among patients with unipolar depression (UD) or bipolar depression in a 5-year follow-up, and explore their impact on long-term outcome. Patients and methods: A total of 333 eligible patients with current major depressive episode were observed and followed up from the first index prescription for 5 years. Lack of persistence or treatment interruption was defined as a gap of at least 2 consecutive months without taking any medication...
2018: Patient Preference and Adherence
https://www.readbyqxmd.com/read/29763711/efficacy-and-acceptability-of-non-invasive-brain-stimulation-for-the-treatment-of-adult-unipolar-and-bipolar-depression-a-systematic-review-and-meta-analysis-of-randomised-sham-controlled-trials
#5
REVIEW
Julian Mutz, Daniel R Edgcumbe, Andre R BrunoniMD, Cynthia H Y FuMD
We examined the efficacy and acceptability of non-invasive brain stimulation in adult unipolar and bipolar depression. Randomised sham-controlled trials of transcranial direct current stimulation (tDCS), transcranial magnetic stimulation (TMS) and theta-burst stimulation (TBS), without co-initiation of another treatment, were included. We analysed effects on response, remission, all-cause discontinuation rates and continuous depression severity measures. Fifty-six studies met our criteria for inclusion (N  = 3,058, mean age = 44...
May 12, 2018: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/29761591/psychological-distress-in-lung-cancer-survivors-at-least-one-year-after-diagnosis-results-of-a-german-multicenter-cross-sectional-study
#6
Martin Eichler, Marlene Hechtner, Beatrice Wehler, Roland Buhl, Jan Stratmann, Martin Sebastian, Heinz Schmidberger, Jessica Peuser, Cornelius Kortsik, Ursula Nestle, Sebastian Wiesemann, Hubert Wirtz, Thomas Wehler, Maria Blettner, Susanne Singer
OBJECTIVE: Despite the high incidence of lung cancer, little is known about distress in lung cancer survivors and patients who have survived diagnose for at least one year. We investigated distress prevalence and associated factors. METHODS: We performed a multicenter (n=6 hospitals) cross-sectional study. Data were collected using medical records, questionnaires, and a telephone interview. Distress was measured with the Patient Health Questionnaire (PHQ-4). Odds ratios (OR) for factors potentially associated with distress were calculated using multivariable logistic regression...
May 14, 2018: Psycho-oncology
https://www.readbyqxmd.com/read/29761488/psychological-therapies-for-treatment-resistant-depression-in-adults
#7
REVIEW
Sharea Ijaz, Philippa Davies, Catherine J Williams, David Kessler, Glyn Lewis, Nicola Wiles
BACKGROUND: Antidepressants are a first-line treatment for adults with moderate to severe major depression. However, many people prescribed antidepressants for depression don't respond fully to such medication, and little evidence is available to inform the most appropriate 'next step' treatment for such patients, who may be referred to as having treatment-resistant depression (TRD). National Institute for Health and Care Excellence (NICE) guidance suggests that the 'next step' for those who do not respond to antidepressants may include a change in the dose or type of antidepressant medication, the addition of another medication, or the start of psychotherapy...
May 14, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29761101/fibromyalgia-syndrome-a-case-report-on-controlled-remission-of-symptoms-by-a-dietary-strategy
#8
Silvia Maria Lattanzio, Francesca Imbesi
A 34-year-old woman suffered from significant chronic pain, depression, non-restorative sleep, chronic fatigue, severe morning stiffness, leg cramps, irritable bowel syndrome, hypersensitivity to cold, concentration difficulties, and forgetfulness. Blood tests were negative for rheumatic disorders. The patient was diagnosed with Fibromyalgia syndrome (FMS). Due to the lack of effectiveness of pharmacological therapies in FMS, she approached a novel metabolic proposal for the symptomatic remission. Its core idea is supporting serotonin synthesis by allowing a proper absorption of tryptophan assumed with food, while avoiding, or at least minimizing the presence of interfering non-absorbed molecules, such as fructose and sorbitol...
2018: Frontiers in Medicine
https://www.readbyqxmd.com/read/29750548/predictors-of-response-to-combined-wake-and-light-therapy-in-treatment-resistant-inpatients-with-depression
#9
Mette Kragh, Erik Roj Larsen, Klaus Martiny, Dorthe Norden Møller, Camilla Schultz Wihlborg, Tove Lindhardt, Poul Videbech
There is growing evidence for combined chronotherapeutic interventions as adjunctive treatments for major depression. However, as the treatments can be demanding, we need to identify predictors of response. This study aimed to describe predictors of response, remission and deterioration in the short-term phase, as well as predictors of long-term response. The predictors investigated were gender, type of depression, severity of depression, treatment resistance, quetiapine use, general self-efficacy, educational level and positive diurnal variation...
May 11, 2018: Chronobiology International
https://www.readbyqxmd.com/read/29749006/predictors-of-recurrence-in-remitted-late-life-depression
#10
Yi Deng, Douglas R McQuoid, Guy G Potter, David C Steffens, Kimberly Albert, Meghan Riddle, John L Beyer, Warren D Taylor
BACKGROUND: Late-life depression (LLD) is associated with a fragile antidepressant response and high recurrence risk. This study examined what measures predict recurrence in remitted LLD. METHODS: Individuals of age 60 years or older with a Diagnostic and Statistical Manual - IV (DSM-IV) diagnosis of major depressive disorder were enrolled in the neurocognitive outcomes of depression in the elderly study. Participants received manualized antidepressant treatment and were followed longitudinally for an average of 5 years...
May 10, 2018: Depression and Anxiety
https://www.readbyqxmd.com/read/29748055/a-pilot-study-of-bed-nucleus-of-the-stria-terminalis-deep-brain-stimulation-in-treatment-resistant-depression
#11
Paul B Fitzgerald, Rebecca Segrave, Karyn E Richardson, Laura A Knox, Sally Herring, Zafiris J Daskalakis, Richard G Bittar
BACKGROUND: Studies are increasingly investigating the therapeutic effects of deep brain stimulation (DBS) applied to a variety of brain regions in the treatment of patients with highly treatment refractory depression. Limited research to date has investigated the therapeutic potential of DBS applied to the Bed Nucleus Of Stria Terminalis (BNST). OBJECTIVE: The aim of this study was to explore the therapeutic potential of DBS applied to the BNST. METHOD: Five patients with highly treatment resistant depression underwent DBS to the BNST in an open label case series design...
April 23, 2018: Brain Stimulation
https://www.readbyqxmd.com/read/29739287/collaborative-care-management-associated-with-improved-depression-outcomes-in-patients-with-personality-disorders-compared-to-usual-primary-care
#12
Jeremy J Solberg, Mark E Deyo-Svendsen, Kelsey R Nylander, Elliot J Bruhl, Dagoberto Heredia, Kurt B Angstman
BACKGROUND: The use of a collaborative care management (CCM) model can dramatically improve short- and long-term treatment outcomes for patients with major depressive disorder (MDD). Patients with comorbid personality disorder (PD) may experience poorer treatment outcomes for MDD. Our study seeks to examine the differences in MDD treatment outcomes for patients with comorbid PD when using a CCM approach rather than usual care (UC). METHODS: In our retrospective cohort study, we reviewed the records of 9614 adult patients enrolled in our depression registry with the clinical diagnosis MDD and the diagnosis of PD (Yes/No)...
January 2018: Journal of Primary Care & Community Health
https://www.readbyqxmd.com/read/29739130/a-cross-sectional-analysis-of-patterns-and-predictors-of-medication-adherence-in-bipolar-disorder-single-center-experience-from-south-india
#13
Nivedhitha Selvakumar, Vikas Menon, Shivan Kattimani
Objective: Our objective was to determine patterns and predictors of medication adherence in bipolar disorder. Methods: Between August 2015 and December 2016, we recruited 160 patients with a diagnosis of bipolar disorder as per International Classification of Diseases-10: Clinical Descriptions and Diagnostic Guidelines. The diagnosis was further confirmed by using the MINI International Neuropsychiatric Inventory. All of them were currently in remission (confirmed by standard measures) and on stable dosing of medication for at least a year...
May 31, 2018: Clinical Psychopharmacology and Neuroscience: the Official Scientific Journal of the Korean College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29738717/the-habenula-in-neurosurgery-for-depression-a-convergence-of-functional-neuroanatomy-psychiatry-and-imaging
#14
REVIEW
Georgios P Skandalakis, Christos Koutsarnakis, Aristotelis V Kalyvas, Panagiotis Skandalakis, Elizabeth O Johnson, George Stranjalis
BACKGROUND: The habenula is a small, mostly underrated structure in the pineal region. Multidisciplinary findings demonstrate an underlying complex connectivity of the habenula with the rest of the brain, subserving its major role in normal behavior and the pathophysiology of depression. These findings suggest the potential application of "habenular psychosurgery" in the treatment of mental disorders. OBJECTIVE/HYPOTHESIS: The remission of two patients with treatment-resistant major depression treated with deep brain stimulation of the habenula supported the hypothesis that the habenula is an effective target for deep brain stimulation and initiated a surge of basic science research...
May 5, 2018: Brain Research
https://www.readbyqxmd.com/read/29734670/depression-olfaction-and-quality-of-life-a-mutual-relationship
#15
REVIEW
Marion Rochet, Wissam El-Hage, Sami Richa, François Kazour, Boriana Atanasova
Olfactory dysfunction has been well studied in depression. Common brain areas are involved in depression and in the olfactory process, suggesting that olfactory impairments may constitute potential markers of this disorder. Olfactory markers of depression can be either state (present only in symptomatic phases) or trait (persistent after symptomatic remission) markers. This study presents the etiology of depression, the anatomical links between olfaction and depression, and a literature review of different olfactory markers of depression...
May 4, 2018: Brain Sciences
https://www.readbyqxmd.com/read/29727073/efficacy-safety-and-durability-of-repeated-ketamine-infusions-for-comorbid-posttraumatic-stress-disorder-and-treatment-resistant-depression
#16
C Sophia Albott, Kelvin O Lim, Miriam K Forbes, Christopher Erbes, Susanna J Tye, John G Grabowski, Paul Thuras, Tegan M Batres-Y-Carr, Joseph Wels, Paulo R Shiroma
OBJECTIVE: The present study examined the efficacy, safety, and durability of repeated ketamine infusions for the treatment of comorbid posttraumatic stress disorder (PTSD) and treatment-resistant depression (TRD) in a sample of veterans. METHODS: Individuals with comorbid DSM-5-defined PTSD and DSM-IV-defined major depressive disorder (N = 15) received 6 intravenous ketamine infusions (0.5 mg/kg) on a Monday-Wednesday-Friday schedule over a 12-day period from May 2015 to June 2016...
May 1, 2018: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/29726909/fatigue-anxiety-depression-and-quality-of-life-in-kidney-transplant-recipients-haemodialysis-patients-patients-with-a-haematological-malignancy-and-healthy-controls
#17
Marit S van Sandwijk, Doaa Al Arashi, Fons M van de Hare, J M Rolien van der Torren, Marie-José Kersten, Joost A Bijlsma, Ineke J M Ten Berge, Frederike J Bemelman
Background: The impact of haemodialysis (HD) and kidney transplantation on quality of life (QoL) is often underestimated due to a lack of comparative studies with other patient groups. Methods: We conducted a cross-sectional cohort study in 168 patients including HD patients, kidney transplant recipients (KTR), patients with a haematological malignancy either receiving chemotherapy or in remission and healthy controls. All participants completed the 36-item short form survey of health-related quality of life, the Checklist Individual Strength and the Hospital Anxiety and Depression Scale questionnaire...
May 2, 2018: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29718600/relative-efficacy-and-acceptability-of-antidepressant-drugs-in-adults-with-major-depressive-disorder-commentary-on-a-network-meta-analysis
#18
Chittaranjan Andrade
A large number of antidepressant drugs are available across the world. All have been compared against placebo, and many have been compared with some but not all other antidepressants. There is therefore little information about a hierarchy of the efficacy and acceptability of these drugs. About 9 years ago, a network meta-analysis attempted to rank the efficacy and acceptability of 12 newer antidepressant drugs in adults with major depressive disorder. Very recently, this network meta-analysis was updated to include 21 antidepressant drugs, most of which were introduced during the 1980s and afterward...
March 2018: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/29717092/controlled-joint-inflammation-but-still-no-remission-it-s-time-to-attend-to-depressive-symptoms
#19
EDITORIAL
Patricia L Dobkin, Gilles Boire
No abstract text is available yet for this article.
May 2018: Journal of Rheumatology
https://www.readbyqxmd.com/read/29714106/meta-analysis-of-the-efficacy-and-acceptability-of-cognitive-behavioural-therapy-for-arab-adult-populations-experiencing-anxiety-depression-or-post-traumatic-stress-disorder
#20
Rony Kayrouz, Blake F Dear, Bechara Kayrouz, Eyal Karin, Milena Gandy, Nickolai Titov
A meta-analysis of the literature of cognitive behaviour therapy (CBT) with Arab adult populations experiencing anxiety, depression or post-traumatic stress disorder (PTSD) was conducted. Nine studies (n = 536) met the eligibility criteria. Three of the nine studies (33%) were randomised control trials using waitlist control groups. All studies (100%) reported a statistically significant reduction in psychological symptoms at post-treatment with large effect sizes for anxiety (effect size, 95% confidence interval) (1...
May 1, 2018: Cognitive Behaviour Therapy
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