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sporotrichosis

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https://www.readbyqxmd.com/read/29347940/domestic-feline-contribution-in-the-transmission-of-sporothrix-in-rio-de-janeiro-state-brazil-a-comparison-between-infected-and-non-infected-populations
#1
Pãmella A Macêdo-Sales, Simone R L S Souto, Carolina A Destefani, Ricardo P Lucena, Ricardo Luiz D Machado, Marcia R Pinto, Anderson M Rodrigues, Leila M Lopes-Bezerra, Elisabeth M S Rocha, Andréa Regina S Baptista
BACKGROUND: Sporotrichosis is a neglected zoonosis caused by pathogenic fungi belonging to the Sporothrix schenckii complex. In Rio de Janeiro state, this disease reached an epidemic status with over 4700 domestic felines and around 4000 humans affected since the mid-90s. The present study evaluated clinical and epidemiological aspects and also the frequency of colonization and infection by these fungi in healthy cats and among those with suspicious cutaneous lesions, inhabiting four Rio de Janeiro state distinct areas...
January 18, 2018: BMC Veterinary Research
https://www.readbyqxmd.com/read/29340472/disseminated-cutaneous-sporotrichosis-in-patient-with-alcoholism
#2
Ana Maria Benvegnú, Juliana Stramari, Lia Natália Diehl Dallazem, Raíssa Massaia Londero Chemello, André Avelino Costa Beber
Sporotrichosis is the most prevalent subcutaneous mycosis and is characterized by a subacute or chronic development of a cutaneous or subcutaneous nodular lesion. It is caused by the dimorphic fungus Sporothrix spp, which may manifest in different clinical forms. The disseminated cutaneous form is uncommon and is more likely to occur in immunocompromised patients. We report a 47-year-old male patient with multiple cutaneous and subcutaneous nodules. The patient was diagnosed with disseminated cutaneous sporotrichosis based on the isolation and identification of Sporothrix spp...
November 2017: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/29260114/ocular-sporotrichosis-a-frequently-misdiagnosed-cause-of-granulomatous-conjunctivitis-in-epidemic-areas
#3
João Paulo M Yamagata, Fabiana B Rudolph, Maria Clara L Nobre, Leninha V Nascimento, Felipe Maurício S Sampaio, Andrea Arinelli, Dayvison F Freitas
Purpose: Sporotrichosis is a subcutaneous mycosis caused by Sporothrix sp., a dimorphic fungus. Although the cutaneous form is the most frequent form, the ocular presentation has been increasingly diagnosed in epidemic areas. We describe three cases of ocular sporotrichosis with the involvement of the ocular adnexa due to autoinoculation without trauma with successful antifungal treatment. Observations: Patient 1: A 68-year-old woman presented with granulomatous conjunctivitis of the right eye with an ulcerated nodule on the right temporal region for 5 months...
December 2017: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29222709/successful-treatment-of-canine-sporotrichosis-with-terbinafine-case-reports-and-literature-review
#4
Paula Gonçalves Viana, Anna Barreto Fernandes Figueiredo, Isabella Dib Ferreira Gremião, Luisa Helena Monteiro de Miranda, Isabela Maria da Silva Antonio, Jéssica Sepulveda Boechat, Ana Caroline de Sá Machado, Manoel Marques Evangelista de Oliveira, Sandro Antonio Pereira
Sporotrichosis occurs worldwide, and the metropolitan region of Rio de Janeiro, Brazil, is a main endemic area, with a large number of human and animal cases in the last 19 years. This mycosis is more frequently described in cats rather than in dogs. There are a limited number of oral antifungal agents for the treatment of sporotrichosis in animals. In this context, the effectiveness of terbinafine in the treatment of sporotrichosis in humans, as well as the promising results of in vitro susceptibility tests, inspired us to use this drug in the therapy of this mycosis in dogs...
December 8, 2017: Mycopathologia
https://www.readbyqxmd.com/read/29221633/proteases-of-sporothrix-schenckii-cytopathological-effects-on-a-host-cell-model
#5
Myrna Sabanero López, Lérida L Flores Villavicencio, Karla Soto Arredondo, Gloria Barbosa Sabanero, Julio César Villagómez-Castro, Gustavo Cruz Jiménez, Gerardo Sandoval Bernal, Haydee Torres Guerrero
BACKGROUND: Sporotrichosis is a fungal infection caused by the Sporothrix schenckii complex. The adhesion of the fungus to the host tissue has been considered the key step in the colonization and invasion, but little is known about the early events in the host-parasite interaction. AIMS: To evaluate the proteolytic activity of S. schenckii on epithelial cells. METHODS: The proteolytic system (at pH 5 and 7) was evaluated using azocoll and zymograms...
December 5, 2017: Revista Iberoamericana de Micología
https://www.readbyqxmd.com/read/29204393/lymphocutaneous-sporotrichosis-treated-with-potassium-iodide-with-development-of-subclinical-hypothyroidism-wolff-chaikoff-effect
#6
Pooja Arora, M Raihan, Asha Kubba, Ram K Gautam
Sporotrichosis is a subcutaneous mycotic infection caused by Sporothrix schenckii that is acquired by traumatic implantation. The diagnosis is established by demonstration of fungal elements on histopathology and culture. Potassium iodide, azole antifungals, and terbinafine are the treatment options available. In this article, we report a 60-year-old female with lymphocutaneous sporotrichosis that responded well to potassium iodide. However, subclinical hypothyroidism (Wolff-Chaikoff effect) was encountered as a side effect of therapy which was managed with thyroxine replacement...
November 2017: Indian Dermatology Online Journal
https://www.readbyqxmd.com/read/29204336/sporotrichosis-by-sporothrix-schenckii-senso-stricto-with-itraconazole-resistance-and-terbinafine-sensitivity-observed-in-vitro-and-in-vivo-case-report
#7
Rodrigo Vettorato, Daiane Heidrich, Fernanda Fraga, Amanda Carvalho Ribeiro, Danielle Machado Pagani, Carina Timotheo, Tais Guarienti Amaro, Gerson Vettorato, Maria Lúcia Scroferneker
We report a case of a patient with lymphocutaneous sporotrichosis in the right upper limb. The fungus was identified as Sporothrix schenckii senso stricto by calmodulin gene sequencing. The initial treatment was itraconazole (200 mg/day), but in vitro antifungal susceptibility demonstrated high resistant to this and another six antifungals, with exception to terbinafine. The lesions did not regress with itraconazole treatment. Thus, 500 mg/day of terbinafine was prescribed and clinical cure was obtained after four months...
March 2018: Medical Mycology Case Reports
https://www.readbyqxmd.com/read/29166494/sporotrichosis-an-update-on-epidemiology-etiopathogenesis-laboratory-and-clinical-therapeutics
#8
Rosane Orofino-Costa, Priscila Marques de Macedo, Anderson Messias Rodrigues, Andréa Reis Bernardes-Engemann
In the late 90's there was a change in both the route of transmission and the people at risk for sporotrichosis. This zoonotic cat-man alternative transmission route elicited changes in strategies to control the epidemic. There was a progressive increase in the number of cases involving especially children and the elderly. In addition to becoming hyperendemic, uncommon clinical pictures like immunoreactive clinical presentations or severe systemic cases have emerged. New species were identified and classified through molecular tools using more virulent clinical isolates, like S...
September 2017: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/29164168/aids-related-endemic-mycoses-in-western-cape-south-africa-and-clinical-mimics-a-cross-sectional-study-of-adults-with-advanced-hiv-and-recent-onset-widespread-skin-lesions
#9
Ilan S Schwartz, Chris Kenyon, Rannakoe Lehloenya, Saskya Claasens, Zandile Spengane, Hans Prozesky, Rosie Burton, Arifa Parker, Sean Wasserman, Graeme Meintjes, Marc Mendelson, Jantjie Taljaard, Johann W Schneider, Natalie Beylis, Bonnie Maloba, Nelesh P Govender, Robert Colebunders, Sipho Dlamini
Background: Skin lesions are common in advanced HIV infection and are sometimes caused by serious diseases like systemic mycoses (SM). AIDS-related SM endemic to Western Cape, South Africa, include emergomycosis (formerly disseminated emmonsiosis), histoplasmosis, and sporotrichosis. We previously reported that 95% of patients with AIDS-related emergomycosis had skin lesions, although these were frequently overlooked or misdiagnosed clinically. Prospective studies are needed to characterize skin lesions of SM in South Africa and to help distinguish these from common HIV-related dermatoses...
2017: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/29147593/rapidly-progressive-disseminated-sporotrichosis-as-the-first-presentation-of-hiv-infection-in-a-patient-with-a-very-low-cd4-cell-count
#10
Isis Cristine Morávia Ribeiro de Oliveira-Esteves, Guilherme Almeida Rosa da Silva, Walter de Araujo Eyer-Silva, Rodrigo Panno Basílio-de-Oliveira, Luciana Ferreira de Araujo, Carlos José Martins, Rogério Neves-Motta, Marcelo Costa Velho Mendes de Azevedo, Dario José Hart Pontes Signorini, Jorge Francisco da Cunha Pinto, Lívia Machado Moura, Rafael Jacyntho Laterça, Diogo Raphael Garcia de Oliveira Pereira, Isabela Vieira do Lago, Fernando Raphael de Almeida Ferry
Sporotrichosis is a human and animal disease caused by species of the Sporothrix schenckii complex. It is classically acquired through traumatic inoculation of fungal elements. Most frequently, sporotrichosis presents as a fixed cutaneous or as a lymphocutaneous form. A much smaller number of cases occur as cutaneous disseminated and disseminated forms. These cases require immediate diagnosis and management to reduce morbidity and mortality. We present the case of a 34-year-old male patient in whom the first presentation of HIV infection was a rapidly progressive sporotrichosis with multiple cutaneous lesions, a high fungal burden in tissues, and pulmonary involvement...
2017: Case Reports in Infectious Diseases
https://www.readbyqxmd.com/read/29080316/sporotrichosis-transmitted-by-a-cockatiel-nymphicus-hollandicus
#11
V Fichman, I D F Gremião, A A V Mendes-Júnior, F M S Sampaio, D F S Freitas, M M E Oliveira, R Almeida-Paes, A C F Valle, M C Gutierrez-Galhardo
Sporotrichosis is caused by dimorphic, pathogenic species from the genus Sporothrix, which are found in nature as saprophytes in decaying vegetation and soil. Classic transmission occurs after traumatic inoculation while manipulating contaminated plant material, and zoonotic transmission is uncommon. The genus Sporothrix contains relevant species with diverse clinical features, infection routes and virulence traits. This article is protected by copyright. All rights reserved.
October 28, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29058171/cavitary-pulmonary-sporotrichosis-case-report-and-literature-review
#12
Florencia D Rojas, Mariana S Fernández, Juan Manuel Lucchelli, Dora Lombardi, José Malet, María Eugenia Vetrisano, María Emilia Cattana, María de Los Ángeles Sosa, Gustavo Giusiano
A case of cavitary pulmonary sporotrichosis without mucocutaneous involvement caused by Sporothrix schenckii is reported in a sexagenarian woman with a long smoking history. The patient was hospitalized for septic shock with multiorgan failure from a respiratory focus. The diagnosis was delayed due to the fungal etiological agent was not initially considered in the differential diagnosis. A good clinical and radiological evolution was obtained with the antifungal therapy. Occasional cases of primary pulmonary sporotrichosis have been reported in the literature...
December 2017: Mycopathologia
https://www.readbyqxmd.com/read/29033815/cutaneous-nocardiosis-simulating-cutaneous-lymphatic-sporotrichosis
#13
Pedro Secchin, Beatriz Moritz Trope, Larissa Araujo Fernandes, Glória Barreiros, Marcia Ramos-E-Silva
Sporotrichosis is the subcutaneous mycosis caused by several species of the Sporothrix genus. With worldwide occurrence, the State of Rio de Janeiro is presently undergoing a zoonotic sporotrichosis epidemic. The form of lymphocutaneous nocardiosis is rare, being caused especially by Nocardia brasiliensis. It appears as a nodular or ulcerated lesion, with multiple painful erythematous nodules or satellite pustules distributed along the lymphatic tract, similar to the lymphocutaneous variant of sporotrichosis...
May 2017: Case Reports in Dermatology
https://www.readbyqxmd.com/read/29026615/an-unusual-cutaneous-infection-caused-by-mycobacterium-marinum
#14
Federica Veronese, Elisa Zavattaro, Pamela Farinelli, Enrico Colombo, Paola Savoia
Introduction.Mycobacterium marinum is a non-tubercular mycobacterium residing in fresh or salt water (in tropical or temperate areas); it is a fish and human pathogen, and in immunocompromised patients can cause severe cutaneous and subcutaneous infections. Case presentation. A 46-year-old white man who underwent immunosuppressive therapy was admitted to our department in May 2016 for skin lesions previously diagnosed as 'unusual erysipelas'. We rejected the hypothesis of erysipelas, due to the clinical features, and our diagnostic hypotheses were oriented towards sporotrichosis, atypical mycobacteriosis, cutaneous tuberculosis and cutaneous sarcoidosis...
April 2017: JMM Case Reports
https://www.readbyqxmd.com/read/29018254/genetic-variation-of-sporothrix-globosa-isolates-from-diverse-geographic-and-clinical-origins-in-china
#15
Lipei Zhao, Yan Cui, Yu Zhen, Lei Yao, Ying Shi, Yang Song, Ruili Chen, Shanshan Li
Sporothrix globosa is the main causative agent of sporotrichosis, a common mycosis that usually affects the skin, in China. Despite increasing efforts in the molecular identification of this fungal pathogen, its modes of transmission and epidemiology remain poorly understood. The goals of this study were to assess the genetic diversity of S. globosa using amplified fragment length polymorphism (AFLP) analysis and to assess the correlation of AFLP profiles with the geographic origins, growth rates, clinical forms, and antifungal susceptibilities of S...
October 11, 2017: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/28989052/in-silico-analysis-of-cytochrome-p450-monooxygenases-in-chronic-granulomatous-infectious-fungus-sporothrix-schenckii-special-focus-on-cyp51
#16
Retshedisitswe Godfrey Matowane, Lukasz Wieteska, Hans Denis Bamal, Ipeleng Kopano Rosinah Kgosiemang, Mari Van Wyk, Nessie Agnes Manume, Sara Mohamed Hasaan Abdalla, Samson Sitheni Mashele, Dominik Gront, Khajamohiddin Syed
Sporotrichosis is an emerging chronic, granulomatous, subcutaneous, mycotic infection caused by Sporothrix species. Sporotrichosis is treated with the azole drug itraconazole as ketoconazole is ineffective. It is a well-known fact that azole drugs act by inhibiting cytochrome P450 monooxygenases (P450s), heme-thiolate proteins. To date, nothing is known about P450s in Sporothrix schenckii and the molecular basis of its resistance to ketoconazole. Here we present genome-wide identification, annotation, phylogenetic analysis and comprehensive P450 family-level comparative analysis of S...
October 5, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28984226/clotrimazole-is-highly-effective-in-vitro-against-feline-sporothrix-brasiliensis-isolates
#17
Thalita Gagini, Luana Pereira Borba-Santos, Anderson Messias Rodrigues, Zoilo Pires de Camargo, Sonia Rozental
PURPOSE: Sporothrix brasiliensis, the most virulent species in the Sporothrix schenckii complex, is responsible for the ongoing epidemics of human and animal sporotrichosis in Brazil. Feline outbreaks are usually driven by S. brasiliensis and followed by extensive transmission to humans. Itraconazole is the first-line treatment for both feline and human sporotrichosis; however, reduced sensitivity is an emerging issue. Thus, we investigated the effect of the widely used antifungal clotrimazole - alone or in combination with itraconazole - against the pathogenic (yeast) form of feline and human S...
October 6, 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28972025/differences-in-clinical-ocular-outcomes-between-exogenous-and-endogenous-endophthalmitis-caused-by-sporothrix-a-systematic-review-of-published-literature
#18
Max Carlos Ramírez Soto
BACKGROUND: Sporotrichosis is an implantation mycosis caused by Sporothrix species prevalent worldwide, which occasionally can also result in intraocular infection presenting as an exogenous or endogenous infection (disseminated sporotrichosis). Knowledge in its clinical recognition and management is limited. AIMS: To systematically review and analyse data from published literature with a view to comparing clinical outcomes between exogenous and endogenous endophthalmitis caused by Sporothrix...
September 28, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28966608/tacrolimus-increases-the-effectiveness-of-itraconazole-and-fluconazole-against-sporothrix-spp
#19
Luana P Borba-Santos, Leandro F Reis de Sá, Juliene A Ramos, Anderson M Rodrigues, Zoilo P de Camargo, Sonia Rozental, Antonio Ferreira-Pereira
Calcineurin inhibitors - such as the clinically used drug tacrolimus - are active against important fungal pathogens, particularly when combined with azoles. However, tacrolimus has not been tested against sporotrichosis, an endemic subcutaneous mycosis with worldwide distribution. Here, we evaluated the activity of tacrolimus and cyclosporine A in vitro - as monotherapy and in combination with itraconazole or fluconazole - against yeasts of Sporothrix brasiliensis and S. schenckii, the main sporotrichosis agents in Brazil...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28919888/the-sporothrix-schenckii-gene-encoding-for-the-ribosomal-protein-l6-has-constitutive-and-stable-expression-and-works-as-an-endogenous-control-in-gene-expression-analysis
#20
Elías Trujillo-Esquivel, José A Martínez-Álvarez, Diana M Clavijo-Giraldo, Nahúm V Hernández, Alberto Flores-Martínez, Patricia Ponce-Noyola, Héctor M Mora-Montes
Sporothrix schenckii is one of the causative agents of sporotrichosis, a worldwide-distributed mycosis that affects humans and other mammals. The interest in basic and clinical features of this organism has significantly increased in the last years, yet little progress in molecular aspects has been reported. Gene expression analysis is a set of powerful tools that helps to assess the cell response to changes in the extracellular environment, the genetic networks controlling metabolic pathways, and the adaptation to different growth conditions...
2017: Frontiers in Microbiology
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