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https://www.readbyqxmd.com/read/28774696/neglected-endemic-mycoses
#1
REVIEW
Flavio Queiroz-Telles, Ahmed Hassan Fahal, Diego R Falci, Diego H Caceres, Tom Chiller, Alessandro C Pasqualotto
Fungi often infect mammalian hosts via the respiratory route, but traumatic transcutaneous implantation is also an important source of infections. Environmental exposure to spores of pathogenic fungi can result in subclinical and unrecognised syndromes, allergic manifestations, and even overt disease. After traumatic cutaneous inoculation, several fungi can cause neglected mycoses such as sporotrichosis, chromoblastomycosis, mycetoma, entomophthoramycosis, and lacaziosis. Most of these diseases have a subacute to chronic course and they can become recalcitrant to therapy and lead to physical disabilities, including inability to work, physical deformities, and amputations...
July 31, 2017: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/28706855/a-rare-case-of-disseminated-sporothrix-schenckii-with-bone-marrow-involvement-in-a-patient-with-idiopathic-cd4-lymphocytopenia
#2
Kruti J Yagnik, William Paul Skelton, Angela Olson, Cesar A Trillo, Jorge Lascano
Sporothrix schenckii is a pathogen with a predilection for dissemination in immunocompromised individuals, often with HIV. We report a case of disseminated sporotrichosis in an unfortunate 25 year old male (without HIV) who was originally treated for presumed pneumonia. The patient continued to worsen clinically and further work-up eventually revealed Sporothrix schenckii species with involvement of multiple organs including the skin, heart, lungs and bone marrow. Despite treatment with multiple antibacterials and antifungals, he ultimately passed away...
2017: IDCases
https://www.readbyqxmd.com/read/28702316/sporotrichosis-in-a-liver-transplant-patient-a-case-report-and-literature-review
#3
Renato Ferreira da Silva, Miguel Bonfitto, Francisco Inaldo Mendes da Silva Junior, Margarete Teresa Gottardo de Ameida, Rita de Cma da Silva
The liver transplant patient was admitted to the hospital with hyperemic, granulomatous, ulcerated lesion in the anterior compartment of the right lower limb with report of local trauma. The agent Sporothrix schenckii was isolated from biopsy of the lesion and lymph nodes of the right lower limb. In this case, the treatment was difficult because the patient has severe pulmonary hypertension and took the following drugs: warfarin, sildenafil, and tacrolimus. These medicines interact with the antifungal, which made it difficult...
September 2017: Medical Mycology Case Reports
https://www.readbyqxmd.com/read/28699881/chemical-composition-and-cytotoxicity-of-extracts-of-marjoram-and-rosemary-and-their-activity-against-sporothrix-brasiliensis
#4
Stefanie Bressan Waller, Isabel Martins Madrid, Jéssica Fernanda Hoffmann, Tony Picoli, Marlete Brum Cleff, Fábio Clasen Chaves, Renata Osório de Faria, Mário Carlos Araújo Meireles, João Roberto Braga de Mello
PURPOSE: Motivated by increasing reports of antifungal resistance in human and animal sporotrichosis, this study evaluated the chemical composition, cytotoxicity and anti-Sporothrix brasiliensis activity of extracts of marjoram (Origanum majorana) and rosemary (Rosmarinus officinalis). METHODOLOGY: Ten (INF10) and 60 min (INF60) infusions, a decoction and a hydroalcoholic extract (HAE, 70 %) were prepared from both plants (10 % w/v). The extract composition was analysed by liquid chromatography/mass spectrometry and the cytotoxicity was evaluated using a colorimetric assay in canine and feline kidney cells...
July 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28687406/comparative-efficacy-and-toxicity-of-two-vaccine-candidates-against-sporothrix-schenckii-using-either-montanide%C3%A2-pet-gel-a-or-aluminum-hydroxide-adjuvants-in-mice
#5
Deivys Leandro Portuondo, Alexander Batista-Duharte, Lucas Souza Ferreira, Cleverton Roberto de Andrade, Camila Quinello, Damiana Téllez-Martínez, Maria Luiza de Aguiar Loesch, Iracilda Zeppone Carlos
Sporotrichosis is an important zoonosis in Brazil and the most frequent subcutaneous mycosis in Latin America, caused by different Sporothrix species. Currently, there is no effective vaccine available to prevent this disease. In this study, the efficacy and toxicity of the adjuvant Montanide™ Pet Gel A (PGA) formulated with S. schenckii cell wall proteins (ssCWP) was evaluated and compared with that of aluminum hydroxide (AH). Balb/c mice received two subcutaneous doses (1st and 14th days) of either the unadjuvanted or adjuvanted vaccine candidates...
July 4, 2017: Vaccine
https://www.readbyqxmd.com/read/28681818/molecular-identification-and-phenotypic-characterisation-of-sporothrix-globosa-from-clinical-cases-of-eastern-assam-north-east-india
#6
Reema Nath, Pinky Lahon, Longmindar Timung
Sporotrichosis is known to be endemic in the state of Assam, North-east India, which is situated in the Sub-Himalayan region. This disease is an acute or chronic infection caused by Sporothrix schenckii species complex which currently includes several species of clinical relevance such as Sporothrix brasiliensis, Sporothrix globosa, Sporothrix schenckii sensu stricto, Sporothrix albicans, Sporothrix mexicana, Sporothrix pallida and Sporothrix luriei. S. globosa is the prevalent species in India. Eight culture-positive patients were diagnosed from suspected consecutive cases of two lymphocutaneous and six fixed cutaneous forms over a period of 4 years in a clinical mycology laboratory of a tertiary care centre in Eastern Assam...
April 2017: Indian Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28670680/subcutaneous-mycoses-in-peru-a-systematic-review-and-meta-analysis-for-the-burden-of-disease
#7
Max Carlos Ramírez Soto, German Malaga
BACKGROUND: There is a worrying lack of epidemiological data on the geographical distribution and burden of subcutaneous mycoses in Peru, hindering the implementation of surveillance and control programs. OBJECTIVES: This study aimed to estimate the disease burden of subcutaneous mycoses in Peru and identify which fungal species were commonly associated with these mycoses. METHODS: We performed a meta-analysis after a systematic review of the published literature in PubMed, LILACS, and SciELO to estimate the burden of subcutaneous mycoses in 25 regions in Peru...
July 3, 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/28645771/dectin-1-expression-by-macrophages-and-related-antifungal-mechanisms-in-a-murine-model-of-sporothrix-schenckii-sensu-stricto-systemic-infection
#8
Juliana Aparecida Jellmayer, Lucas Souza Ferreira, Francine Alessandra Manente, Amanda Costa Gonçalves, Marisa Campos Polesi, Alexander Batista-Duharte, Iracilda Zeppone Carlos
The available information about the role of Dectin-1 in sporotrichosis is scarce. Hence, we aimed to assess Dectin-1 expression by macrophages and the activation of some related antifungal mechanisms during the Sporothrix schenckii sensu stricto infection as a first attempt to elucidate the role of this receptor in sporotrichosis. Balb/c mice were intraperitoneally infected with S. schenckii sensu stricto yeast ATCC 16345 and euthanized on days 5, 10 and 15 post-infection, when the following parameters were evaluated: fungal burden in spleen, Dectin-1 expression and nitric oxide (NO) production by peritoneal macrophages, as well as IL-1β, TNF-α and IL-10 ex vivo secretion by these same cells...
June 20, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28627095/sporotrichosis-masquerading-as-pyoderma-gangrenosum
#9
R B Lima, M A J Jeunon-Sousa, T Jeunon, J C Oliveira, M M E Oliveira, R M Zancopé-Oliveira, A C S Moraes
Sporotrichosis is a subcutaneous mycosis with a worldwide distribution caused by species of the Sporothrix schenkii complex. Since 1998, it has reached epidemic proportions in the city of Rio de Janeiro, Brazil, via transmission from infected cats to humans. The species identified as the primary cause was Sporothrix brasiliensis. This article is protected by copyright. All rights reserved.
June 19, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28595275/antifungal-susceptibility-of-sporothrix-schenckii-complex-biofilms
#10
Raimunda Sâmia Nogueira Brilhante, Felipe Rodrigues Magalhães de Aguiar, Maria Lucilene Queiroz da Silva, Jonathas Sales de Oliveira, Zoilo Pires de Camargo, Anderson Messias Rodrigues, Vandbergue Santos Pereira, Rosana Serpa, Débora de Souza Collares Maia Castelo-Branco, Edmilson Emanuel Monteiro Correia, Waldemiro Aquino Pereira-Neto, Rossana de Aguiar Cordeiro, Marcos Fábio Gadelha Rocha, José Júlio Costa Sidrim
Sporotrichosis, caused by species of Sporothrix schenckii complex, is the most prevalent subcutaneous mycosis in many areas of Latin America. The aim of this study was to evaluate the ability of Sporothrix spp. to form biofilms in vitro and to characterize the growth kinetics, morphology, and antifungal susceptibility of biofilms against classical antifungals. We investigated the ability of strains to produce biofilms in vitro and determined the effects of exposure to amphotericin B, itraconazole, caspofungin, ketoconazole, voriconazole, and fluconazole at minimum inhibitory concentration (MIC) against planktonic form and at 10× MIC and 50× MIC on the biomass and metabolic activity of these biofilms...
June 8, 2017: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/28591261/sporotrichoid-leishmaniasis-a-cross-sectional-clinical-epidemiological-and-laboratory-study-in-rio-de-janeiro-state-brazil
#11
COMPARATIVE STUDY
Livia Martins Veloso de Carvalho, Maria Inês Fernandes Pimentel, Fátima Conceição-Silva, Érica de Camargo Ferreira E Vasconcellos, Cláudia Maria Valete-Rosalino, Marcelo Rosandiski Lyra, Mariza de Matos Salgueiro, Maurício Naoto Saheki, Maria de Fátima Madeira, Eliame Mouta-Confort, Liliane de Fátima Antonio, Aline Fagundes da Silva, Leonardo Pereira Quintella, Sandro Javier Bedoya-Pacheco, Armando de Oliveira Schubach
Background: Atypical presentations of cutaneous leishmaniasis include sporotrichoid leishmaniasis (SL), which is clinically described as a primary ulcer combined with lymphangitis and nodules and/or ulcerated lesions along its pathway. Aims: To assess the differences between patients with sporotrichoid leishmaniasis and typical cutaneous leishmaniasis (CL). Methods: From January 2004 to December 2010, 23 cases of SL (4.7%) were detected among 494 CL patients diagnosed at a reference center for the disease in Rio de Janeiro State, Brazil...
June 1, 2017: Revista do Instituto de Medicina Tropical de São Paulo
https://www.readbyqxmd.com/read/28575449/efficacy-of-a-poly-aggregated-formulation-of-amphotericin-b-in-treating-systemic-sporotrichosis-caused-by-sporothrix-brasiliensis
#12
Kelly Ishida, Rafaela Alves Castro, Juan J Torrado, Dolores Remedios Serrano, Luana Pereira Borba-Santos, Leonardo Pereira Quintella, Wanderley de Souza, Sonia Rozental, Leila M Lopes-Bezerra
In severe cases of sporotrichosis, it is recommended to use amphotericin B deoxycholate (D-AMB) or its lipid formulations and/or in association with itraconazole (ITC). Our aim was to evaluate the antifungal efficacy of a poly-aggregated amphotericin B (P-AMB), a nonlipid formulation, compared with D-AMB on systemic sporotrichosis caused by Sporothrix brasiliensis. In vitro assays showed that Sporothrix schenckii sensu stricto and S. brasiliensis yeast clinical isolates were susceptible to low concentrations of P-AMB and D-AMB...
June 1, 2017: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/28566662/practical-management-of-deep-cutaneous-fungal-infections
#13
Tomotaka Sato
Understanding deep cutaneous fungal infection requires not only reading many case reports and checking the typical clinical images of skin lesions, but also managing the patients properly to prevent misdiagnosis. Herein, I review my recent experiences with eight typical cases of deep cutaneous infections (including protothecosis and nocardiosis) in Japan. It is very important to do the four management processes; namely, KOH direct microscopic examination, skin biopsy, fungal culture, and microscopic examination of the histopathological specimen of PAS and Grocott staining...
2017: Medical Mycology Journal
https://www.readbyqxmd.com/read/28539922/sporothrix-schenckii-sensu-stricto-and-sporothrix-brasiliensis-are-differentially-recognized-by-human-peripheral-blood-mononuclear-cells
#14
José A Martínez-Álvarez, Luis A Pérez-García, Erika Mellado-Mojica, Mercedes G López, Iván Martínez-Duncker, Leila M Lópes-Bezerra, Héctor M Mora-Montes
Sporothrix schenckii sensu stricto and S. brasiliensis are usually associated to sporotrichosis, a subcutaneous mycosis worldwide distributed. Comparative analyses between these two species indicate they contain genetic and physiological differences that are likely to impact the interaction with host cells. Here, we study the composition of the cell wall from conidia, yeast-like cells and germlings of both species and found they contained the same sugar composition. The carbohydrate proportion in the S. schenckii sensu stricto wall was similar across the three cell morphologies, with exception in the chitin content, which was significantly different in the three morphologies...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28492800/fungal-infection-control-by-garlic-extracts-allium-sativum-l-and-modulation-of-peritoneal-macrophages-activity-in-murine-model-of-sporotrichosis
#15
J P Burian, L V S Sacramento, I Z Carlos
Garlic (Allium sativum L.) is grown all over the world as seasoning and medicinal vegetable since 3,000 BC. Allicin is the main component of garlic, being attributed to it the most of its biological activities, such as bactericidal, antifungal and antiviral actions. However, other compounds of garlic present antioxidant, hypocholesterolemic, vasodilator activities, protective action against different types of cancer, and immunomodulatory. Fungal infections are important causes of morbidity and mortality in people mainly in immunosuppressed ones...
May 4, 2017: Brazilian Journal of Biology, Revista Brasleira de Biologia
https://www.readbyqxmd.com/read/28488313/sporotrichosis-among-children-of-a-hyperendemic-area-in-peru-an-8-year-retrospective-study
#16
Max C Ramírez Soto
BACKGROUND: The clinical and epidemiologic characteristics of pediatric sporotrichosis are poorly understood. OBJECTIVE: To describe the incidence and clinical characteristics of cases of sporotrichosis in children 14 years of age and younger reported in Abancay from 2004 to 2011, stratified according to age. METHODS: We performed a retrospective review of pediatric patients 14 years of age and younger who were diagnosed with sporotrichosis in a referral center at Abancay, a poor area located in the south central highlands of Peru, to estimate the incidence rates (per 100,000 person-years) according to age and sporotrichosis type (lymphocutaneous and fixed), and clinical characteristics of these patients...
May 9, 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/28482071/polar-origanum-vulgare-lamiaceae-extracts-with-antifungal-potential-against-sporothrix-brasiliensis
#17
Stefanie Bressan Waller, Jéssica Fernanda Hoffmann, Isabel Martins Madrid, Tony Picoli, Marlete Brum Cleff, Fabio Clasen Chaves, Régis A Zanette, João Roberto Braga de Mello, Renata Osório de Faria, Mário Carlos Araújo Meireles
Oregano (Origanum vulgare) has anti-Sporothrix spp. activity, including against strains that are resistant to antifungal drugs. As the studies are limited to the essential oil, the aim of this study was to evaluate the chemical, antioxidant and cytotoxic properties of polar oregano extracts and their anti-Sporothrix brasiliensis activity. Aerial plant parts were used in the preparation of 10 min (INF10) and 60 min (INF60) infusions, a decoction (DEC) and a hydroalcoholic extract (HAE). Six phenolic acids and four flavonoids were identified and quantified through liquid-chromatography (LC-MS)...
May 6, 2017: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/28472490/in-vitro-susceptibility-of-sporothrix-brasiliensis-comparison-of-yeast-and-mycelial-phases
#18
Karine Ortiz Sanchotene, Tchana Martinez Brandolt, Gabriel Baracy Klafke, Vanice Rodrigues Poester, Melissa Orzechowski Xavier
Sporothrix brasiliensis has emerged as an important cause of sporotrichosis, particularly associated with feline and zoonotic cases. Owing to the paucity of data on antifungal activity against this species, the present study aimed to evaluate the in vitro susceptibility of clinical isolates of S. brasiliensis in the mycelial and yeast phases to itraconazole (ITZ), terbinafine (TRB), and amphotericin B (AMB). Thirty-five isolates from an outbreak of feline sporotrichosis in Southern Brazil were used. All of them were assessed in the yeast and filamentous phases using the broth microdilution technique in accordance with the respective reference protocols M27-A3 and M38-A2 of the Clinical and Laboratory Standards Institute (CLSI)...
May 4, 2017: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/28443986/minimal-inhibitory-concentration-distributions-and-epidemiological-cutoff-values-of-five-antifungal-agents-against-sporothrix-brasiliensis
#19
Rodrigo Almeida-Paes, Fábio Brito-Santos, Maria Helena Galdino Figueiredo-Carvalho, Ana Caroline Sá Machado, Manoel Marques Evangelista Oliveira, Sandro Antonio Pereira, Maria Clara Gutierrez-Galhardo, Rosely Maria Zancopé-Oliveira
BACKGROUND: Sporothrix brasiliensis is the most virulent sporotrichosis agent. This species usually responds to antifungal drugs, but therapeutic failure can occur in some patients. Antifungal susceptibility tests have been performed on this species, but no clinical breakpoints (CBPs) are available. In this situation, minimal inhibitory concentration (MIC) distributions and epidemiological cutoff values (ECVs) support the detection of identification of resistant strains. OBJECTIVES: To study the MIC distributions of five antifungal drugs against S...
May 2017: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/28427354/unique-case-report-of-a-chromomycosis-and-listeria-in-soft-tissue-and-cerebellar-abscesses-after-kidney-transplantation
#20
J Tourret, N Benabdellah, S Drouin, F Charlotte, J Rottembourg, N Arzouk, A Fekkar, B Barrou
BACKGROUND: Chromomycosis is a rare mycotic infection encountered in tropical and subtropical regions. The disease presents as a slowly-evolving nodule that can become infected with bacteria. Here, we describe a unique association of abscesses caused by a chromomycosis and Listeria monocytogenes in a kidney transplant recipient, and didactically expose how the appropriate diagnosis was reached. CASE PRESENTATION: A 49-year old male originating from the Caribbean presented a scalp lesion which was surgically removed in his hometown where it was misdiagnosed as a sporotrichosis on histology, 3 years after he received a kidney transplant...
April 20, 2017: BMC Infectious Diseases
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