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sporotrichosis

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https://www.readbyqxmd.com/read/28539922/sporothrix-schenckii-sensu-stricto-and-sporothrix-brasiliensis-are-differentially-recognized-by-human-peripheral-blood-mononuclear-cells
#1
José A Martínez-Álvarez, Luis A Pérez-García, Erika Mellado-Mojica, Mercedes G López, Iván Martínez-Duncker, Leila M Lópes-Bezerra, Héctor M Mora-Montes
Sporothrix schenckii sensu stricto and S. brasiliensis are usually associated to sporotrichosis, a subcutaneous mycosis worldwide distributed. Comparative analyses between these two species indicate they contain genetic and physiological differences that are likely to impact the interaction with host cells. Here, we study the composition of the cell wall from conidia, yeast-like cells and germlings of both species and found they contained the same sugar composition. The carbohydrate proportion in the S. schenckii sensu stricto wall was similar across the three cell morphologies, with exception in the chitin content, which was significantly different in the three morphologies...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28492800/fungal-infection-control-by-garlic-extracts-allium-sativum-l-and-modulation-of-peritoneal-macrophages-activity-in-murine-model-of-sporotrichosis
#2
J P Burian, L V S Sacramento, I Z Carlos
Garlic (Allium sativum L.) is grown all over the world as seasoning and medicinal vegetable since 3,000 BC. Allicin is the main component of garlic, being attributed to it the most of its biological activities, such as bactericidal, antifungal and antiviral actions. However, other compounds of garlic present antioxidant, hypocholesterolemic, vasodilator activities, protective action against different types of cancer, and immunomodulatory. Fungal infections are important causes of morbidity and mortality in people mainly in immunosuppressed ones...
May 4, 2017: Brazilian Journal of Biology, Revista Brasleira de Biologia
https://www.readbyqxmd.com/read/28488313/sporotrichosis-among-children-of-a-hyperendemic-area-in-peru-an-8-year-retrospective-study
#3
Max C Ramírez Soto
BACKGROUND: The clinical and epidemiologic characteristics of pediatric sporotrichosis are poorly understood. OBJECTIVE: To describe the incidence and clinical characteristics of cases of sporotrichosis in children 14 years of age and younger reported in Abancay from 2004 to 2011, stratified according to age. METHODS: We performed a retrospective review of pediatric patients 14 years of age and younger who were diagnosed with sporotrichosis in a referral center at Abancay, a poor area located in the south central highlands of Peru, to estimate the incidence rates (per 100,000 person-years) according to age and sporotrichosis type (lymphocutaneous and fixed), and clinical characteristics of these patients...
May 9, 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/28482071/polar-origanum-vulgare-lamiaceae-extracts-with-antifungal-potential-against-sporothrix-brasiliensis
#4
Stefanie Bressan Waller, Jéssica Fernanda Hoffmann, Isabel Martins Madrid, Tony Picoli, Marlete Brum Cleff, Fabio Clasen Chaves, Régis A Zanette, João Roberto Braga de Mello, Renata Osório de Faria, Mário Carlos Araújo Meireles
Oregano (Origanum vulgare) has anti-Sporothrix spp. activity, including against strains that are resistant to antifungal drugs. As the studies are limited to the essential oil, the aim of this study was to evaluate the chemical, antioxidant and cytotoxic properties of polar oregano extracts and their anti-Sporothrix brasiliensis activity. Aerial plant parts were used in the preparation of 10 min (INF10) and 60 min (INF60) infusions, a decoction (DEC) and a hydroalcoholic extract (HAE). Six phenolic acids and four flavonoids were identified and quantified through liquid-chromatography (LC-MS)...
May 6, 2017: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/28472490/in-vitro-susceptibility-of-sporothrix-brasiliensis-comparison-of-yeast-and-mycelial-phases
#5
Karine Ortiz Sanchotene, Tchana Martinez Brandolt, Gabriel Baracy Klafke, Vanice Rodrigues Poester, Melissa Orzechowski Xavier
Sporothrix brasiliensis has emerged as an important cause of sporotrichosis, particularly associated with feline and zoonotic cases. Owing to the paucity of data on antifungal activity against this species, the present study aimed to evaluate the in vitro susceptibility of clinical isolates of S. brasiliensis in the mycelial and yeast phases to itraconazole (ITZ), terbinafine (TRB), and amphotericin B (AMB). Thirty-five isolates from an outbreak of feline sporotrichosis in Southern Brazil were used. All of them were assessed in the yeast and filamentous phases using the broth microdilution technique in accordance with the respective reference protocols M27-A3 and M38-A2 of the Clinical and Laboratory Standards Institute (CLSI)...
May 4, 2017: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/28443986/minimal-inhibitory-concentration-distributions-and-epidemiological-cutoff-values-of-five-antifungal-agents-against-sporothrix-brasiliensis
#6
Rodrigo Almeida-Paes, Fábio Brito-Santos, Maria Helena Galdino Figueiredo-Carvalho, Ana Caroline Sá Machado, Manoel Marques Evangelista Oliveira, Sandro Antonio Pereira, Maria Clara Gutierrez-Galhardo, Rosely Maria Zancopé-Oliveira
BACKGROUND: Sporothrix brasiliensis is the most virulent sporotrichosis agent. This species usually responds to antifungal drugs, but therapeutic failure can occur in some patients. Antifungal susceptibility tests have been performed on this species, but no clinical breakpoints (CBPs) are available. In this situation, minimal inhibitory concentration (MIC) distributions and epidemiological cutoff values (ECVs) support the detection of identification of resistant strains. OBJECTIVES: To study the MIC distributions of five antifungal drugs against S...
May 2017: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/28427354/unique-case-report-of-a-chromomycosis-and-listeria-in-soft-tissue-and-cerebellar-abscesses-after-kidney-transplantation
#7
J Tourret, N Benabdellah, S Drouin, F Charlotte, J Rottembourg, N Arzouk, A Fekkar, B Barrou
BACKGROUND: Chromomycosis is a rare mycotic infection encountered in tropical and subtropical regions. The disease presents as a slowly-evolving nodule that can become infected with bacteria. Here, we describe a unique association of abscesses caused by a chromomycosis and Listeria monocytogenes in a kidney transplant recipient, and didactically expose how the appropriate diagnosis was reached. CASE PRESENTATION: A 49-year old male originating from the Caribbean presented a scalp lesion which was surgically removed in his hometown where it was misdiagnosed as a sporotrichosis on histology, 3 years after he received a kidney transplant...
April 20, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28380215/recombinant-60-kda-heat-shock-protein-from-paracoccidioides-brasiliensis-is-it-a-good-antigen-for-serological-diagnosis-of-paracoccidioidomycosis
#8
G Peron, F F Fernandes, T N Landgraf, R Martinez, A Panunto-Castelo
Paracoccidioides brasiliensis and P. lutzii are fungi that cause paracoccidioidomycosis (PCM), the most prevalent systemic mycosis in South America. For serological diagnosis, although 43-kDa glycoprotein (gp43) is regarded as highly specific for PCM, the occurrence of false negative reactions in sera from patients infected with P. lutzii suggests that preparation with only one antigen is not recommended. Heat shock proteins are feasible alternatives as a second antigen because they are often highly immunogenic...
April 3, 2017: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/28349410/disseminated-sporotrichosis-with-osteolytic-bone-involvement
#9
Paul B Aronowitz, Meghan Gilroy, Katerina N Christiansen
No abstract text is available yet for this article.
March 27, 2017: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/28327256/origin-and-distribution-of-sporothrix-globosa-causing-sapronoses-in-asia
#10
Tarek A A Moussa, Naif M S Kadasa, Hassan S Al Zahrani, Sarah Abdallah Ahmed, Peiying Feng, Albertus H G Gerrits van den Ende, Yu Zhang, Rui Kano, Fuqiu Li, Shanshan Li, Yang Song, Bilin Dong, Luana Rossato, Somayeh Dolatabadi, Sybren de Hoog
PURPOSE: The aim of the study was to evaluate the main sources and epidemiological patterns and speculate on the evolutionary origin of Sporothrix globosa in Asia. METHODOLOGY: Case and case series literature on sporotrichosis in Asia from January 2007 onwards were reviewed using meta-analysis. Phylogenetic analysis of relevant S. globosa was carried out on the basis of concatenated sequences of ITS, TEF3 and CAL. A haplotype network of CAL sequences of 281 Sporothrix isolates was analysed to determine the population structure of S...
May 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28316596/the-efficacy-of-humanized-antibody-against-the-sporothrix-antigen-gp70-in-promoting-phagocytosis-and-reducing-disease-burden
#11
José R F de Almeida, Karla L Santiago, Gilberto H Kaihami, Andrea Q Maranhão, Marcelo de Macedo Brígido, Sandro R de Almeida
Sporotrichosis is a subcutaneous mycosis distributed worldwide and is frequently reported in countries with tropical climates, as Latin America countries. We previously demonstrated that mice with sporotrichosis produce specific antibodies against a 70-kDa fungal protein, indicating that specific antibodies against this molecule may help to control the sporotrichosis. IgG1 monoclonal antibody was generated, and called mAbP6E7, in mice against a 70-kDa glycoprotein (gp70) of S. schenckii. The mAbP6E7 showed prophylactic and therapeutic activity against sporotrichosis...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28286151/oxidative-stress-in-rats-experimentally-infected-by-sporothrix-schenckii
#12
Verônica S P Castro, Aleksandro S Da Silva, Gustavo R Thomé, Patrícia Wolkmer, Jorge L C Castro, Márcio M Costa, Dominguita L Graça, Daniele C Oliveira, Sydney H Alves, Maria R C Schetinger, Sonia T A Lopes, Lenita M Stefani, Maria I Azevedo, Matheus D Baldissera, Cinthia M Andrade
The aim of this study was to evaluate whether oxidative stress occurs in rats experimentally infected by Sporothrix schenckii, and its possible effect on disease pathogenesis. Thirty rats were divided into two groups: the group A (uninfected, n = 18) and the group B (infected by S. schenckii, n=21). Blood samples were collected on days 15, 30 and 40 post-infection (PI). At each sampling time, six rats of the group A, and seven of the group B were bled. TBARS (thiobarbituric acid reactive substances) levels in serum samples were measured to evaluate lipid peroxidation...
March 7, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28219829/chemical-and-cytotoxic-analyses-of-brown-brazilian-propolis-apis%C3%A2-mellifera-and-its-in%C3%A2-vitro-activity-against-itraconazole-resistant%C3%A2-sporothrix-brasiliensis
#13
Stefanie B Waller, Cristina M Peter, Jéssica F Hoffmann, Tony Picoli, Luiza da G Osório, Fábio Chaves, João L Zani, Renata O de Faria, João R B de Mello, Mário C A Meireles
This study aimed to evaluate the chemical composition and cytotoxic activity of brown Brazilian propolis and its in vitro activity against itraconazole-resistant Sporothrix brasiliensis from animal sporotrichosis. Propolis was acquired commercially and prepared as a hydroalcoholic extract. Chemical analysis was evaluated by liquid chromatography coupled to mass spectrometry of ultra-efficiency. The cell viability was evaluated by MTT test in MDBK cells of 50 to 0.09 μg/mL. For antifungal tests, twenty isolates of Sporothrix brasiliensis from dogs (n = 11) and cats (n = 9) with sporotrichosis were tested to itraconazole (16-0...
April 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28140444/the-nlrp3-inflammasome-contributes-to-host-protection-during-sporothrix-schenckii-infection
#14
Amanda Costa Gonçalves, Lucas Souza Ferreira, Francine Alessandra Manente, Carolina Maria Quinello Gomes de Faria, Marisa Campos Polesi, Cleverton Roberto de Andrade, Dario Simões Zamboni, Iracilda Zeppone Carlos
Sporotrichosis is a mycosis caused by fungi from the Sporothrix schenckii species complex, whose prototypical member is Sporothrix schenckii sensu stricto. Pattern recognition receptors (PRRs) recognize and respond to pathogen-associated molecular patterns (PAMPs) and shape the following adaptive immune response. A family of PRRs most frequently associated with fungal recognition is the nucleotide-binding oligomerization domain-like receptor (NLR). After PAMP recognition, NLR family pyrin domain-containing 3 (NLRP3) binds to apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC) and caspase-1 to form the NLRP3 inflammasome...
June 2017: Immunology
https://www.readbyqxmd.com/read/28133872/comparison-of-two-in%C3%A2-vitro-antifungal-sensitivity-tests-and-monitoring-during-therapy-of-sporothrix-schenckii-sensu-stricto-in-malaysian-cats
#15
Hock Siew Han, Rui Kano, Charles Chen, Chiara Noli
BACKGROUND: Feline sporotrichosis is common in Malaysia. Thermosensitivity and effects of azole treatment on fungal susceptibility are unknown. OBJECTIVES: To evaluate thermotolerance and antifungal susceptibility of feline Malaysian Sporothrix isolates, compare microdilution (MD) and E-test results, and investigate changes in susceptibility during azole therapy. METHODS: Sporothrix schenckii sensu stricto was isolated from 44 cats. Thermotolerance was determined via culture at 37°C for 7 days...
February 2017: Veterinary Dermatology
https://www.readbyqxmd.com/read/28103311/zoonotic-epidemic-of-sporotrichosis-cat-to-human-transmission
#16
Isabella Dib Ferreira Gremião, Luisa Helena Monteiro Miranda, Erica Guerino Reis, Anderson Messias Rodrigues, Sandro Antonio Pereira
No abstract text is available yet for this article.
January 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28042367/the-upside-of-bias-a-case-of-chronic-meningitis-due-to-sporothrix-schenckii-in-an-immunocompetent-host
#17
Christine Hessler, Carol A Kauffman, Felicia C Chow
Chronic meningitis of unknown etiology is a vexing illness for patients and clinicians. Identification of the correct pathogen can be challenging and time consuming, leading to delays in appropriate treatment. Although Sporothrix schenckii is a recognized and treatable cause of chronic meningitis, neurologists and infectious diseases physicians may not regularly evaluate for Sporothrix infection. We describe an immunocompetent patient with chronic meningitis who partially responded to empiric fluconazole. Prompted by a recent culture-confirmed case of meningeal sporotrichosis, we tested for S schenckii antibodies from the cerebrospinal fluid, which were positive...
January 2017: Neurohospitalist
https://www.readbyqxmd.com/read/27914747/sporothrix-schenckii-sensu-lato-identification-in-fragments-of-skin-lesion-cultured-in-nnn-medium-for-differential-diagnosis-of-cutaneous-leishmaniasis
#18
Liliane de Fátima Antonio, Maria Inês Fernandes Pimentel, Marcelo Rosandiski Lyra, Maria de Fátima Madeira, Luciana de Freitas Campos Miranda, Rodrigo Almeida Paes, Fábio Brito-Santos, Maria Helena Galdino Figueredo Carvalho, Armando de Oliveira Schubach
Eighty-nine patients with clinical suspicion of leishmaniasis were referred for differential diagnosis. Sporothrix schenckii sensu lato was isolated in Novy-MacNeal-Nicolle + Schneider media in 98% of 64 patients with final diagnosis of sporotrichosis. This medium may be suitable for diagnosis of sporotrichosis in areas where cutaneous leishmaniasis is also endemic.
February 2017: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/27861481/-presence-of-lactoferrin-lf-in-lymphocutaneous-sporotrichosis-yeast-bound-antimicrobial-peptide
#19
Alejandro Palma-Ramos, Laura E Castrillón-Rivera, María Elisa Vega-Mémije, Roberto Arenas-Guzmán, Lucía Rangel-Gamboa
Sporotrichosis is a common subcutaneous mycosis in Latin America, produced by dimorphic fungi belong to Sporothrix schenckii complex of cryptic species. Infection is acquired by traumatic inoculation with contaminated organic material. Host immune response includes polymorphonuclear neutrophils chemotaxis and release of granular components. Lactoferrin is a protein member of the transferrin family of iron-binding proteins, present inside polymorphonuclear granular structure, and has been reported to affect growth and development of infectious agents, including fungal organisms...
November 2016: Gaceta Médica de México
https://www.readbyqxmd.com/read/27856302/anti-inflammatory-activity-of-vismia-guianensis-aubl-pers-extracts-and-antifungal-activity-against-sporothrix-schenckii
#20
A H Oliveira, G G de Oliveira, F Carnevale Neto, D F Portuondo, A Batista-Duharte, I Z Carlos
ETHNOPHARMACOLOGICAL RELEVANCE: Vismia guianensis (Aubl.) Pers. is traditionally used in North and Northeast of Brazil for the treatment of dermatomycoses. Since the strategy associating immunomodulators with antifungal drugs seems to be promissory to improve the treatment efficacy in fungal infections, we aimed to investigate the antifungal activity of V. guianensis ethanolic extract of leaves (VGL) and bark (VGB) against Sporothrix schenckii ATCC 16345 and their antinflammatory activities...
January 4, 2017: Journal of Ethnopharmacology
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