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https://www.readbyqxmd.com/read/28443986/minimal-inhibitory-concentration-distributions-and-epidemiological-cutoff-values-of-five-antifungal-agents-against-sporothrix-brasiliensis
#1
Rodrigo Almeida-Paes, Fábio Brito-Santos, Maria Helena Galdino Figueiredo-Carvalho, Ana Caroline Sá Machado, Manoel Marques Evangelista Oliveira, Sandro Antonio Pereira, Maria Clara Gutierrez-Galhardo, Rosely Maria Zancopé-Oliveira
BACKGROUND: Sporothrix brasiliensis is the most virulent sporotrichosis agent. This species usually responds to antifungal drugs, but therapeutic failure can occur in some patients. Antifungal susceptibility tests have been performed on this species, but no clinical breakpoints (CBPs) are available. In this situation, minimal inhibitory concentration (MIC) distributions and epidemiological cutoff values (ECVs) support the detection of identification of resistant strains. OBJECTIVES: To study the MIC distributions of five antifungal drugs against S...
May 2017: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/28427354/unique-case-report-of-a-chromomycosis-and-listeria-in-soft-tissue-and-cerebellar-abscesses-after-kidney-transplantation
#2
J Tourret, N Benabdellah, S Drouin, F Charlotte, J Rottembourg, N Arzouk, A Fekkar, B Barrou
BACKGROUND: Chromomycosis is a rare mycotic infection encountered in tropical and subtropical regions. The disease presents as a slowly-evolving nodule that can become infected with bacteria. Here, we describe a unique association of abscesses caused by a chromomycosis and Listeria monocytogenes in a kidney transplant recipient, and didactically expose how the appropriate diagnosis was reached. CASE PRESENTATION: A 49-year old male originating from the Caribbean presented a scalp lesion which was surgically removed in his hometown where it was misdiagnosed as a sporotrichosis on histology, 3 years after he received a kidney transplant...
April 20, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28380215/recombinant-60-kda-heat-shock-protein-from-paracoccidioides-brasiliensis-is-it-a-good-antigen-for-serological-diagnosis-of-paracoccidioidomycosis
#3
G Peron, F F Fernandes, T N Landgraf, R Martinez, A Panunto-Castelo
Paracoccidioides brasiliensis and P. lutzii are fungi that cause paracoccidioidomycosis (PCM), the most prevalent systemic mycosis in South America. For serological diagnosis, although 43-kDa glycoprotein (gp43) is regarded as highly specific for PCM, the occurrence of false negative reactions in sera from patients infected with P. lutzii suggests that preparation with only one antigen is not recommended. Heat shock proteins are feasible alternatives as a second antigen because they are often highly immunogenic...
April 3, 2017: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/28349410/disseminated-sporotrichosis-with-osteolytic-bone-involvement
#4
Paul B Aronowitz, Meghan Gilroy, Katerina N Christiansen
No abstract text is available yet for this article.
March 27, 2017: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/28327256/origin-and-distribution-of-sporothrix-globosa-causing-sapronoses-in-asia
#5
Tarek A A Moussa, Naif M S Kadasa, Hassan S Al Zahrani, Sarah Abdallah Ahmed, Peiying Feng, Albertus H G Gerrits van den Ende, Yu Zhang, Rui Kano, Fuqiu Li, Shanshan Li, Yang Song, Bilin Dong, Luana Rossato, Somayeh Dolatabadi, Sybren de Hoog
PURPOSE: The aim of the study was to evaluate the main sources and epidemiological patterns and speculate on the evolutionary origin of Sporothrix globosa in Asia. METHODOLOGY: Case and case series literature on sporotrichosis in Asia from January 2007 onwards were reviewed using meta-analysis. Phylogenetic analysis of relevant S. globosa was carried out on the basis of concatenated sequences of ITS, TEF3 and CAL. A haplotype network of CAL sequences of 281 Sporothrix isolates was analysed to determine the population structure of S...
March 23, 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28316596/the-efficacy-of-humanized-antibody-against-the-sporothrix-antigen-gp70-in-promoting-phagocytosis-and-reducing-disease-burden
#6
José R F de Almeida, Karla L Santiago, Gilberto H Kaihami, Andrea Q Maranhão, Marcelo de Macedo Brígido, Sandro R de Almeida
Sporotrichosis is a subcutaneous mycosis distributed worldwide and is frequently reported in countries with tropical climates, as Latin America countries. We previously demonstrated that mice with sporotrichosis produce specific antibodies against a 70-kDa fungal protein, indicating that specific antibodies against this molecule may help to control the sporotrichosis. IgG1 monoclonal antibody was generated, and called mAbP6E7, in mice against a 70-kDa glycoprotein (gp70) of S. schenckii. The mAbP6E7 showed prophylactic and therapeutic activity against sporotrichosis...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28286151/oxidative-stress-in-rats-experimentally-infected-by-sporothrix-schenckii
#7
Verônica S P Castro, Aleksandro S Da Silva, Gustavo R Thomé, Patrícia Wolkmer, Jorge L C Castro, Márcio M Costa, Dominguita L Graça, Daniele C Oliveira, Sydney H Alves, Maria R C Schetinger, Sonia T A Lopes, Lenita M Stefani, Maria I Azevedo, Matheus D Baldissera, Cinthia M Andrade
The aim of this study was to evaluate whether oxidative stress occurs in rats experimentally infected by Sporothrix schenckii, and its possible effect on disease pathogenesis. Thirty rats were divided into two groups: the group A (uninfected, n = 18) and the group B (infected by S. schenckii, n=21). Blood samples were collected on days 15, 30 and 40 post-infection (PI). At each sampling time, six rats of the group A, and seven of the group B were bled. TBARS (thiobarbituric acid reactive substances) levels in serum samples were measured to evaluate lipid peroxidation...
March 7, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28219829/chemical-and-cytotoxic-analyses-of-brown-brazilian-propolis-apis%C3%A2-mellifera-and-its-in%C3%A2-vitro-activity-against-itraconazole-resistant%C3%A2-sporothrix-brasiliensis
#8
Stefanie B Waller, Cristina M Peter, Jéssica F Hoffmann, Tony Picoli, Luiza da G Osório, Fábio Chaves, João L Zani, Renata O de Faria, João R B de Mello, Mário C A Meireles
This study aimed to evaluate the chemical composition and cytotoxic activity of brown Brazilian propolis and its in vitro activity against itraconazole-resistant Sporothrix brasiliensis from animal sporotrichosis. Propolis was acquired commercially and prepared as a hydroalcoholic extract. Chemical analysis was evaluated by liquid chromatography coupled to mass spectrometry of ultra-efficiency. The cell viability was evaluated by MTT test in MDBK cells of 50 to 0.09 μg/mL. For antifungal tests, twenty isolates of Sporothrix brasiliensis from dogs (n = 11) and cats (n = 9) with sporotrichosis were tested to itraconazole (16-0...
April 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28140444/the-nlrp3-inflammasome-contributes-to-host-protection-during-sporothrix-schenckii-infection
#9
Amanda Costa Gonçalves, Lucas Souza Ferreira, Francine Alessandra Manente, Carolina Maria Quinello Gomes de Faria, Marisa Campos Polesi, Cleverton Roberto de Andrade, Dario Simões Zamboni, Iracilda Zeppone Carlos
Sporotrichosis is a mycosis caused by fungi from the Sporothrix schenckii species complex, whose prototypical member is Sporothrix schenckii sensu stricto. Pattern recognition receptors (PRRs) recognize and respond to pathogen-associated molecular patterns (PAMPs) and shape the following adaptive immune response. A family of PRRs most frequently associated with fungal recognition is the nucleotide-binding oligomerization domain-like receptor (NLR). After PAMP recognition, NLR family pyrin domain-containing 3 (NLRP3) binds to apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC) and caspase-1 to form the NLRP3 inflammasome...
January 31, 2017: Immunology
https://www.readbyqxmd.com/read/28133872/comparison-of-two-in%C3%A2-vitro-antifungal-sensitivity-tests-and-monitoring-during-therapy-of-sporothrix-schenckii-sensu-stricto-in-malaysian-cats
#10
Hock Siew Han, Rui Kano, Charles Chen, Chiara Noli
BACKGROUND: Feline sporotrichosis is common in Malaysia. Thermosensitivity and effects of azole treatment on fungal susceptibility are unknown. OBJECTIVES: To evaluate thermotolerance and antifungal susceptibility of feline Malaysian Sporothrix isolates, compare microdilution (MD) and E-test results, and investigate changes in susceptibility during azole therapy. METHODS: Sporothrix schenckii sensu stricto was isolated from 44 cats. Thermotolerance was determined via culture at 37°C for 7 days...
February 2017: Veterinary Dermatology
https://www.readbyqxmd.com/read/28103311/zoonotic-epidemic-of-sporotrichosis-cat-to-human-transmission
#11
Isabella Dib Ferreira Gremião, Luisa Helena Monteiro Miranda, Erica Guerino Reis, Anderson Messias Rodrigues, Sandro Antonio Pereira
No abstract text is available yet for this article.
January 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28042367/the-upside-of-bias-a-case-of-chronic-meningitis-due-to-sporothrix-schenckii-in-an-immunocompetent-host
#12
Christine Hessler, Carol A Kauffman, Felicia C Chow
Chronic meningitis of unknown etiology is a vexing illness for patients and clinicians. Identification of the correct pathogen can be challenging and time consuming, leading to delays in appropriate treatment. Although Sporothrix schenckii is a recognized and treatable cause of chronic meningitis, neurologists and infectious diseases physicians may not regularly evaluate for Sporothrix infection. We describe an immunocompetent patient with chronic meningitis who partially responded to empiric fluconazole. Prompted by a recent culture-confirmed case of meningeal sporotrichosis, we tested for S schenckii antibodies from the cerebrospinal fluid, which were positive...
January 2017: Neurohospitalist
https://www.readbyqxmd.com/read/27914747/sporothrix-schenckii-sensu-lato-identification-in-fragments-of-skin-lesion-cultured-in-nnn-medium-for-differential-diagnosis-of-cutaneous-leishmaniasis
#13
Liliane de Fátima Antonio, Maria Inês Fernandes Pimentel, Marcelo Rosandiski Lyra, Maria de Fátima Madeira, Luciana de Freitas Campos Miranda, Rodrigo Almeida Paes, Fábio Brito-Santos, Maria Helena Galdino Figueredo Carvalho, Armando de Oliveira Schubach
Eighty-nine patients with clinical suspicion of leishmaniasis were referred for differential diagnosis. Sporothrix schenckii sensu lato was isolated in Novy-MacNeal-Nicolle + Schneider media in 98% of 64 patients with final diagnosis of sporotrichosis. This medium may be suitable for diagnosis of sporotrichosis in areas where cutaneous leishmaniasis is also endemic.
February 2017: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/27861481/-presence-of-lactoferrin-lf-in-lymphocutaneous-sporotrichosis-yeast-bound-antimicrobial-peptide
#14
Alejandro Palma-Ramos, Laura E Castrillón-Rivera, María Elisa Vega-Mémije, Roberto Arenas-Guzmán, Lucía Rangel-Gamboa
Sporotrichosis is a common subcutaneous mycosis in Latin America, produced by dimorphic fungi belong to Sporothrix schenckii complex of cryptic species. Infection is acquired by traumatic inoculation with contaminated organic material. Host immune response includes polymorphonuclear neutrophils chemotaxis and release of granular components. Lactoferrin is a protein member of the transferrin family of iron-binding proteins, present inside polymorphonuclear granular structure, and has been reported to affect growth and development of infectious agents, including fungal organisms...
November 2016: Gaceta Médica de México
https://www.readbyqxmd.com/read/27856302/anti-inflammatory-activity-of-vismia-guianensis-aubl-pers-extracts-and-antifungal-activity-against-sporothrix-schenckii
#15
A H Oliveira, G G de Oliveira, F Carnevale Neto, D F Portuondo, A Batista-Duharte, I Z Carlos
ETHNOPHARMACOLOGICAL RELEVANCE: Vismia guianensis (Aubl.) Pers. is traditionally used in North and Northeast of Brazil for the treatment of dermatomycoses. Since the strategy associating immunomodulators with antifungal drugs seems to be promissory to improve the treatment efficacy in fungal infections, we aimed to investigate the antifungal activity of V. guianensis ethanolic extract of leaves (VGL) and bark (VGB) against Sporothrix schenckii ATCC 16345 and their antinflammatory activities...
January 4, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27771622/refractory-sporotrichosis-due-to-sporothrix-brasiliensis-in-humans-appears-to-be-unrelated-to-in-vivo-resistance
#16
Rodrigo Almeida-Paes, Manoel Marques Evangelista Oliveira, Dayvison Francis Saraiva Freitas, Antônio Carlos Francesconi do Valle, Maria Clara Gutierrez-Galhardo, Rosely Maria Zancopé-Oliveira
Sporotrichosis is a subacute to chronic infection caused by members of the Sporothrix schenckii complex. Itraconazole is the first choice antifungal drug for treating this infection, with terbinafine and potassium iodide as alternatives and amphotericin B used in cases of severe infections. Correlation of antifungal susceptibility data with the clinical outcome of the patients is scarce. The aim of this study was to correlate clinical and mycological data in patients with refractory sporotrichosis. In this work, antifungal susceptibilities, determined according to the reference M38-A2 CLSI protocol, of 25 Sporothrix strains, isolated from seven human cases of sporotrichosis with adversities in the treatment, are presented...
October 22, 2016: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/27742285/invasive-fungal-disease-in-renal-transplant-recipients-at-a-brazilian-center-local-epidemiology-matters
#17
L F A Guimarães, M Halpern, A S de Lemos, E F de Gouvêa, R T Gonçalves, M A A da Rosa Santos, M Nucci, G Santoro-Lopes
INTRODUCTION: Invasive fungal disease (IFD) is an important complication after solid organ transplantation (SOT). A marked geographic variation in the epidemiology of IFD after kidney transplantation (KT) has been suggested by the results of previous studies. Nevertheless, data from Latin American centers are scarce. OBJECTIVE: This study sought to describe the epidemiology of IFD at a Brazilian KT center. METHODS: This study was a retrospective single-center cohort study that included patients who underwent KT between 1998 and 2009 and were followed up until July 2015...
September 2016: Transplantation Proceedings
https://www.readbyqxmd.com/read/27663926/tinea-on-a-tattoo
#18
Alexandru Oanţă, Marius Irimie
In the last twenty years, the prevalence of individuals with tattoos in the general population has increased in Europe (1) as well as in Australia (2) and the United States of America (3). A series of complications such as acute inflammatory reactions, allergic contact dermatitis (4,5), photoinduced, lichenoid, and granulomatous reactions (6, 7), pseudolymphoma (8), pseudoepitheliomatous hyperplasia (9), skin infections (6), and skin cancers (10) may occur on tattoos. Infectious complications on tattoos include bacterial infections (pyoderma, leprosy, syphilis, cutaneous tuberculosis, mycobacteriosis) (11-14), viral infections (molluscum contagiosum, warts, herpes simplex, hepatitis B and C) (15-17), and fungal infections (sporotrichosis, dermatophytosis) (18,19)...
August 2016: Acta Dermatovenerologica Croatica: ADC
https://www.readbyqxmd.com/read/27648881/sporotrichosis-associated-hospitalizations-united-states-2000-2013
#19
Jeremy A W Gold, Gordana Derado, Rajal K Mody, Kaitlin Benedict
To determine frequency and risk for sporotrichosis-associated hospitalizations, we analyzed the US 2000-2013 National (Nationwide) Inpatient Sample. An estimated 1,471 hospitalizations occurred (average annual rate 0.35/1 million persons). Hospitalizations were associated with HIV/AIDS, immune-mediated inflammatory diseases, and chronic obstructive pulmonary disease. Although rare, severe sporotrichosis should be considered for at-risk patients.
October 2016: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/27639705/antifungal-and-immunomodulatory-activity-of-a-novel-cochleate-for-amphotericin-b-delivery-against-sporothrix-schenckii
#20
A Batista-Duharte, M Lastre, B Romeu, D L Portuondo, D Téllez-Martínez, F A Manente, O Pérez, I Z Carlos
INTRODUCTION: Sporotrichosis is an emergent subcutaneous mycoses caused by species of the Sporothrix schenckii complex. Amphotericin B (AmB) remains the main antifungal drug for the treatment of systemic infections, but its use is limited by toxicity reasons. AFCo3 is a novel cochleate containing detoxified LPS, which exhibits drug delivery and immunomodulating properties. Here, AFCo3 was used as the vehicle for AmB to evaluate the immunomodulatory and antifungal efficacy against S. schenckii in vitro and in vivo...
November 2016: International Immunopharmacology
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