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https://www.readbyqxmd.com/read/29747448/nodular-lymphangitis-sporotrichoid-lymphocutaneous-infections-clues-to-differential-diagnosis
#1
REVIEW
Andrés Tirado-Sánchez, Alexandro Bonifaz
Nodular lymphangitis, also known as sporotrichoid lymphocutaneous infections, is characterized by suppurative inflammatory nodules along the lymphatic vessels. This manifestation is classic of sporotrichosis, however, other infections such as nocardiosis, atypical mycobacteriosis, leishmaniasis, among others, can also express this clinical pattern. Sporotrichosis, which often occurs in gardeners, remains the most recognized cause of nodular lymphangitis. The histopathological studies, as well as the culture are diagnostic standards of lesions that do not respond to empirical treatment...
May 9, 2018: Journal of Fungi (Basel, Switzerland)
https://www.readbyqxmd.com/read/29747377/sporotrichin-skin-test-for-the-diagnosis-of-sporotrichosis
#2
Alexandro Bonifaz, Conchita Toriello, Javier Araiza, Max C Ramírez-Soto, Andrés Tirado-Sánchez
Sporotrichosis is the most common implantation mycosis caused by several species of the Sporothrix schenckii complex. The gold standard for diagnosis is concerned with the isolation of the fungus; although, fresh examinations, staining, and biopsies are also helpful for this purpose. The sporotrichin is an antigenic complex comprised of a peptide-rhamnomannan, which is relevant with respect to pathogenic fungi; it is primarily used for serological and skin testing. We present a study regarding the use of sporotrichin as a diagnostic aid for cutaneous sporotrichosis...
May 9, 2018: Journal of Fungi (Basel, Switzerland)
https://www.readbyqxmd.com/read/29729723/comparison-of-the-sensitivity-of-three-methods-for-the-early-diagnosis-of-sporotrichosis-in-cats
#3
J N Silva, L H M Miranda, R C Menezes, I D F Gremião, R V C Oliveira, S M M Vieira, F Conceição-Silva, L Ferreiro, S A Pereira
Sporotrichosis is caused by species of fungi within the Sporothrix schenckii complex that infect man and animals. In Rio de Janeiro, Brazil, an epidemic has been observed since 1998, with most of the cases being related to transmission from infected cats. Although the definitive diagnosis of feline sporotrichosis is made by fungal culture, cytopathological and histopathological examinations are used routinely, because the long culture period may delay treatment onset. However, alternative methods are desirable in cases of low fungal burden...
April 2018: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/29684015/cryosurgery-for-the-treatment-of-cutaneous-sporotrichosis-in-four-pregnant-women
#4
Vivian Fichman, Antonio Carlos Francesconi do Valle, Priscila Marques de Macedo, Dayvison Francis Saraiva Freitas, Manoel Marques Evangelista de Oliveira, Rodrigo Almeida-Paes, Maria Clara Gutierrez-Galhardo
BACKGROUND: Pregnant women with sporotrichosis should not receive systemic antifungal therapy except in severe cases when amphotericin B is recommended. Thermotherapy is the most reported treatment described in this group of patients. It entails weeks of daily self-application of heat to the lesions, requires that the patient faithfully apply it, and it could cause skin burns. Cryosurgery is a useful therapeutic tool for many cutaneous infectious diseases, safe for pregnant women, but not well evaluated for sporotrichosis treatment in this group...
April 23, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29652977/-auricular-sporotrichosis-atypical-case-report-simulating-bacterial-cellulitis
#5
Juan Ochoa-Reyes, Ernesto Ramos-Martínez, Rogelio Treviño-Rangel, Gloria M González, Alexandro Bonifaz
Sporotrichosis is the most common subcutaneous or implantation mycosis in Mexico. The case of a preauricular cutaneous-fixed sporotrichosis simulating atypical bacterial cellulitis is reported in an elderly patient with no history of trauma. The biopsy showed a suppurative granuloma with scarce yeast. Sporothrix schenckii was identified in the culture and confirmed by molecular biology. She was treated with itraconazole and a clinical and mycological cure was obtained. The case of atypical presentation is presented, coming from a semi-arid zone with extreme weather...
2018: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
https://www.readbyqxmd.com/read/29629046/a-diabetic-elderly-man-with-finger-ulcer
#6
Noraini Mohamad, Salziyan Badrin, Wan Noor Hasbee Wan Abdullah
Fixed cutaneous sporotrichosis is a differential diagnosis that can be considered in diabetic patients who present with a poorly healing ulcer. Although its prevalence is low, it can occur in patients with immunocompromised status. Here we report a case of a 70-year-old man with diabetes mellitus who presented with a 1-month history of an unhealed ulcer over the tip of his left middle finger. He experienced a cat bite over his left middle finger 1 month prior to the appearance of the lesion. A skin biopsy revealed the presence of Sporothrix schenckii ...
March 2018: Korean Journal of Family Medicine
https://www.readbyqxmd.com/read/29601109/fungal-diseases-in-children-and-adolescents-in-a-referral-centre-in-bogota-colombia
#7
Alvarado Zulma, Pereira Claudia
A cross-sectional descriptive study was conducted at a dermatology referral centre in Bogotá to estimate the frequencies and aetiologies of mycoses in the population under 18 years of age attending the medical mycology laboratory over a 13-year period (2000-2012). A total of 1337 samples from 1221 patients were evaluated, involving direct examination and culture for 1279 samples, direct examination alone for 50 and culture alone for 8. During the study period, dermatophytosis was diagnosed via culture in 537 cases (40...
March 30, 2018: Mycoses
https://www.readbyqxmd.com/read/29559998/the-infection-returns-a-case-of-pulmonary-sporotrichosis-relapse-after-chemotherapy
#8
Samid M Farooqui, Houssein Youness
Background: Pulmonary sporotrichosis is a rare disease caused by a dimorphic fungus, Sporothrix schenckii . It is rarely found in association with malignancy. We present a case of pulmonary sporotrichosis recurrence after chemotherapy. Case Presentation: A 44-year-old man, treated for pulmonary sporotrichosis in the past, presented with dysphagia and was found to have squamous cell carcinoma of the esophagus. After undergoing chemotherapy, extensive cavitary lesions were observed on thoracic computed tomography scan...
2018: Case Reports in Medicine
https://www.readbyqxmd.com/read/29538731/sporotrichosis-between-1898-and-2017-the-evolution-of-knowledge-on-a-changeable-disease-and-on-emerging-etiological-agents
#9
Leila M Lopes-Bezerra, Hector M Mora-Montes, Yu Zhang, Gustavo Nino-Vega, Anderson Messias Rodrigues, Zoilo Pires de Camargo, Sybren de Hoog
The description of cryptic species with different pathogenic potentials has changed the perspectives on sporotrichosis. Sporothrix schenckii causes a benign chronic subcutaneous mycosis, Sporothrix brasiliensis is highly virulent, and Sporothrix globosa mainly causes fixed cutaneous lesions. Furthermore, S. brasiliensis is the prevalent species related to cat-transmitted sporotrichosis. Sources of infection, transmission, and distribution patterns also differ between species, and variability differs between species because of different degrees of clonality...
April 1, 2018: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/29522522/cell-walls-of-the-dimorphic-fungal-pathogens-sporothrix-schenckii-and-sporothrix-brasiliensis-exhibit-bilaminate-structures-and-sloughing-of-extensive-and-intact-layers
#10
Leila M Lopes-Bezerra, Louise A Walker, Gustavo Niño-Vega, Héctor M Mora-Montes, Gabriela W P Neves, Hector Villalobos-Duno, Laura Barreto, Karina Garcia, Bernardo Franco, José A Martínez-Álvarez, Carol A Munro, Neil A R Gow
Sporotrichosis is a subcutaneous mycosis caused by pathogenic species of the Sporothrix genus. A new emerging species, Sporothrix brasiliensis, is related to cat-transmitted sporotrichosis and has severe clinical manifestations. The cell wall of pathogenic fungi is a unique structure and impacts directly on the host immune response. We reveal and compare the cell wall structures of Sporothrix schenckii and S. brasiliensis using high-pressure freezing electron microscopy to study the cell wall organization of both species...
March 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29520092/an-immunoproteomic-approach-revealing-peptides-from-sporothrix-brasiliensis-that-induce-a-cellular-immune-response-in-subcutaneous-sporotrichosis
#11
José Roberto Fogaça de Almeida, Grasielle Pereira Jannuzzi, Gilberto Hideo Kaihami, Leandro Carvalho Dantas Breda, Karen Spadari Ferreira, Sandro Rogério de Almeida
Sporothrix brasiliensis is the most virulent fungus of the Sporothrix complex and is the main species recovered in the sporotrichosis zoonotic hyperendemic area in Rio de Janeiro. A vaccine against S. brasiliensis could improve the current sporotrichosis situation. Here, we show 3 peptides from S. brasiliensis immunogenic proteins that have a higher likelihood for engaging MHC-class II molecules. We investigated the efficiency of the peptides as vaccines for preventing subcutaneous sporotrichosis. In this study, we observed a decrease in lesion diameters in peptide-immunized mice, showing that the peptides could induce a protective immune response against subcutaneous sporotrichosis...
March 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29476824/functional-characterization-of-the-sporothrix-schenckii-ktr4-and-ktr5-mannosyltransferases-involved-in-the-n-linked-glycosylation-pathway
#12
Luz A López-Ramírez, Nahúm V Hernández, Nancy E Lozoya-Pérez, Leila M Lopes-Bezerra, Héctor M Mora-Montes
Sporothrix schenckii is one of the causative agents of the deep-seated mycosis sporotrichosis, a fungal infection with worldwide distribution. Fungus-specific molecules and biosynthetic pathways are potential targets for the development of new antifungal drugs. The MNT1/KRE2 gene family is a group of genes that encode fungus-specific Golgi-resident mannosyltransferases that participate in the synthesis of O-linked and N-linked glycans. While this family is composed of five and nine members in Candida albicans and Saccharomyces cerevisiae, respectively, the S...
April 2018: Research in Microbiology
https://www.readbyqxmd.com/read/29473510/synthesis-and-antifungal-activity-of-coumarins-derivatives-against-sporothrix-spp
#13
Luana da S M Forezi, Luana Pereira Borba-Santos, Mariana F C Cardoso, Vitor F Ferreira, Sonia Rozental, Fernando de C da Silva
Sporotrichosis is a serious public health problem in Brazil that affects human patients and domestic animals, mainly cats. Thus, the search for new antifungal agents is required also due to the emergence and to the lack of effective drugs available in the therapeutic arsenal. The aim of this study was to evaluate the in vitro antifungal profile of two synthetic series of coumarin derivatives against Sporothrix schenckii and Sporothrix brasiliensis. The three-components synthetic routes used for the preparation of coumarin derivatives have proved to be quite efficient and compounds 16 and 17 have been prepared in good yields...
2018: Current Topics in Medicinal Chemistry
https://www.readbyqxmd.com/read/29469701/disseminated-cutaneous-sporotrichosis-presenting-as-a-necrotic-facial-mass-case-and-review
#14
Yong He, Chelsea Ma, Maxwell Fung, Sarah Fitzmaurice
Sporotrichosis is a subcutaneous mycotic infection caused by Sporothrix schenckii, a group of common saprophytes of soil, plants, and organic debris. Disseminated forms may be seen in the setting of immunosuppression and are typically treated initially with intravenous lipidized amphotericin B. We report an unusual case of a 65-year-old woman who developed disseminated cutaneous sporotrichosis with extensive facial involvement in the absence of a known primary inoculation. Her cutaneous lesions completely resolved after treatment with intravenous posaconazole without amphotericin B...
July 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/29440688/unbalanced-inflammatory-reaction-could-increase-tissue-destruction-and-worsen-skin-infectious-diseases-a-comparative-study-of-leishmaniasis-and-sporotrichosis
#15
F N Morgado, L M V de Carvalho, J Leite-Silva, A J Seba, M I F Pimentel, A Fagundes, M F Madeira, M R Lyra, M M Oliveira, A O Schubach, F Conceição-Silva
The clinical presentations of skin diseases produced by different pathogens, as American tegumentary leishmaniasis (ATL) and sporotrichosis can be similar and possibly influenced by the skin immune system (SIS). The aim of the study was to understand the underlying mechanisms of skin inflammation produced by different pathogens. We used immunohistochemistry to analyze 96 patients: a- localized cutaneous leishmaniasis (LCL-ATL); b- sporotrichoid cutaneous leishmaniasis (SCL-ATL); c-lymphocutaneous (LC-SP); d- fixed (F-SP) sporotrichosis...
February 13, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29412358/feline-sporotrichosis-associations-between-clinical-epidemiological-profiles-and-phenotypic-genotypic-characteristics-of-the-etiological-agents-in-the-rio-de-janeiro-epizootic-area
#16
Jéssica Sepulveda Boechat, Manoel Marques Evangelista Oliveira, Rodrigo Almeida-Paes, Isabella Dib Ferreira Gremião, Ana Caroline de Sá Machado, Raquel de Vasconcelos Carvalhaes Oliveira, Anna Barreto Fernandes Figueiredo, Vanessa Brito de Souza Rabello, Karoline Benevides de Lima Silva, Rosely Maria Zancopé-Oliveira, Tânia Maria Pacheco Schubach, Sandro Antonio Pereira
BACKGROUND: Sporotrichosis is caused by species of the genus Sporothrix. From 1998 to 2015, 4,703 cats were diagnosed at the Fundação Oswaldo Cruz (Fiocruz), Rio de Janeiro, Brazil. Even after the description of the Sporothrix species, the characterisation of feline isolates is not performed routinely. OBJECTIVES: To characterise the clinical isolates from cats at the species level and correlate them with the clinical and epidemiological characteristics of the cats...
March 2018: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/29394517/a-population-genetics-analysis-in-clinical-isolates-of-sporothrix-schenckii-based-on-calmodulin-and-calcium-calmodulin-dependent-kinase-partial-gene-sequences
#17
Lucia Rangel-Gamboa, Fernando Martinez-Hernandez, Pablo Maravilla, Ana Flisser
Sporotrichosis is a subcutaneous mycosis that is caused by diverse species of Sporothrix. High levels of genetic diversity in Sporothrix isolates have been reported, but few population genetics analyses have been documented. To analyse the genetic variability and population genetics relations of Sporothrix schenckii Mexican clinical isolates and to compare them with other reported isolates. We studied the partial sequences of calmodulin and calcium/calmodulin-dependent kinase genes in 24 isolates; 22 from Mexico, one from Colombia, and one ATCC® 6331™; the latter was used as a positive control...
February 2, 2018: Mycoses
https://www.readbyqxmd.com/read/29387746/sporotrichosis-in-the-nail-an-unusual-location-and-presentation
#18
Krista N Larson, Shaily Pandey, William Hoover, Natalie Z Sun
No abstract text is available yet for this article.
January 2018: JAAD Case Reports
https://www.readbyqxmd.com/read/29380297/epidemiology-of-fungal-infections-in-china
#19
REVIEW
Min Chen, Yuan Xu, Nan Hong, Yali Yang, Wenzhi Lei, Lin Du, Jingjun Zhao, Xia Lei, Lin Xiong, Langqi Cai, Hui Xu, Weihua Pan, Wanqing Liao
With the increasing number of immunocompromised hosts, the epidemiological characteristics of fungal infections have undergone enormous changes worldwide, including in China. In this paper, we reviewed the existing data on mycosis across China to summarize available epidemiological profiles. We found that the general incidence of superficial fungal infections in China has been stable, but the incidence of tinea capitis has decreased and the transmission route has changed. By contrast, the overall incidence of invasive fungal infections has continued to rise...
February 2018: Frontiers of Medicine
https://www.readbyqxmd.com/read/29371525/cutaneous-disseminated-and-extracutaneous-sporotrichosis-current-status-of-a-complex-disease
#20
REVIEW
Alexandro Bonifaz, Andrés Tirado-Sánchez
Sporotrichosis is an implantation or inoculation mycosis caused by species of Sporothrix schenckii complex; its main manifestations are limited to skin; however, cutaneous-disseminated, disseminated (visceral) and extracutaneous variants of sporotrichosis can be associated with immunosuppression, including HIV-AIDS, chronic alcoholism or more virulent strains. The most common extracutaneous form of sporotrichosis includes pulmonary, osteoarticular and meningeal. The laboratory diagnosis requires observing yeast forms and isolating the fungus; the two main causative agents are Sporothrix schenckii ( ss ) and Sporothrix brasiliensis ...
February 10, 2017: Journal of Fungi (Basel, Switzerland)
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