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sporotrichosis

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https://www.readbyqxmd.com/read/28645771/dectin-1-expression-by-macrophages-and-related-antifungal-mechanisms-in-a-murine-model-of-sporothrix-schenckii-sensu-stricto-systemic-infection
#1
Juliana Aparecida Jellmayer, Lucas Souza Ferreira, Francine Alessandra Manente, Amanda Costa Gonçalves, Marisa Campos Polesi, Alexander Batista-Duharte, Iracilda Zeppone Carlos
The available information about the role of Dectin-1 in sporotrichosis is scarce. Hence, we aimed to assess Dectin-1 expression by macrophages and the activation of some related antifungal mechanisms during the Sporothrix schenckii sensu stricto infection as a first attempt to elucidate the role of this receptor in sporotrichosis. Balb/c mice were intraperitoneally infected with S. schenckii sensu stricto yeast ATCC 16345 and euthanized on days 5, 10 and 15 post-infection, when the following parameters were evaluated: fungal burden in spleen, Dectin-1 expression and nitric oxide (NO) production by peritoneal macrophages, as well as IL-1β, TNF-α and IL-10 ex vivo secretion by these same cells...
June 20, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28627095/sporotrichosis-masquerading-as-pyoderma-gangrenosum
#2
R B Lima, M A J Jeunon-Sousa, T Jeunon, J C Oliveira, M M E Oliveira, R M Zancopé-Oliveira, A C S Moraes
Sporotrichosis is a subcutaneous mycosis with a worldwide distribution caused by species of the Sporothrix schenkii complex. Since 1998, it has reached epidemic proportions in the city of Rio de Janeiro, Brazil, via transmission from infected cats to humans. The species identified as the primary cause was Sporothrix brasiliensis. This article is protected by copyright. All rights reserved.
June 19, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28595275/antifungal-susceptibility-of-sporothrix-schenckii-complex-biofilms
#3
Raimunda Sâmia Nogueira Brilhante, Felipe Rodrigues Magalhães de Aguiar, Maria Lucilene Queiroz da Silva, Jonathas Sales de Oliveira, Zoilo Pires de Camargo, Anderson Messias Rodrigues, Vandbergue Santos Pereira, Rosana Serpa, Débora de Souza Collares Maia Castelo-Branco, Edmilson Emanuel Monteiro Correia, Waldemiro Aquino Pereira-Neto, Rossana de Aguiar Cordeiro, Marcos Fábio Gadelha Rocha, José Júlio Costa Sidrim
Sporotrichosis, caused by species of Sporothrix schenckii complex, is the most prevalent subcutaneous mycosis in many areas of Latin America. The aim of this study was to evaluate the ability of Sporothrix spp. to form biofilms in vitro and to characterize the growth kinetics, morphology, and antifungal susceptibility of biofilms against classical antifungals. We investigated the ability of strains to produce biofilms in vitro and determined the effects of exposure to amphotericin B, itraconazole, caspofungin, ketoconazole, voriconazole, and fluconazole at minimum inhibitory concentration (MIC) against planktonic form and at 10× MIC and 50× MIC on the biomass and metabolic activity of these biofilms...
June 8, 2017: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/28591261/sporotrichoid-leishmaniasis-a-cross-sectional-clinical-epidemiological-and-laboratory-study-in-rio-de-janeiro-state-brazil
#4
Livia Martins Veloso de Carvalho, Maria Inês Fernandes Pimentel, Fátima Conceição-Silva, Érica de Camargo Ferreira E Vasconcellos, Cláudia Maria Valete-Rosalino, Marcelo Rosandiski Lyra, Mariza de Matos Salgueiro, Maurício Naoto Saheki, Maria de Fátima Madeira, Eliame Mouta-Confort, Liliane de Fátima Antonio, Aline Fagundes da Silva, Leonardo Pereira Quintella, Sandro Javier Bedoya-Pacheco, Armando de Oliveira Schubach
Background: Atypical presentations of cutaneous leishmaniasis include sporotrichoid leishmaniasis (SL), which is clinically described as a primary ulcer combined with lymphangitis and nodules and/or ulcerated lesions along its pathway. Aims: To assess the differences between patients with sporotrichoid leishmaniasis and typical cutaneous leishmaniasis (CL). Methods: From January 2004 to December 2010, 23 cases of SL (4.7%) were detected among 494 CL patients diagnosed at a reference center for the disease in Rio de Janeiro State, Brazil...
June 1, 2017: Revista do Instituto de Medicina Tropical de São Paulo
https://www.readbyqxmd.com/read/28575449/efficacy-of-a-poly-aggregated-formulation-of-amphotericin-b-in-treating-systemic-sporotrichosis-caused-by-sporothrix-brasiliensis
#5
Kelly Ishida, Rafaela Alves Castro, Juan J Torrado, Dolores Remedios Serrano, Luana Pereira Borba-Santos, Leonardo Pereira Quintella, Wanderley de Souza, Sonia Rozental, Leila M Lopes-Bezerra
In severe cases of sporotrichosis, it is recommended to use amphotericin B deoxycholate (D-AMB) or its lipid formulations and/or in association with itraconazole (ITC). Our aim was to evaluate the antifungal efficacy of a poly-aggregated amphotericin B (P-AMB), a nonlipid formulation, compared with D-AMB on systemic sporotrichosis caused by Sporothrix brasiliensis. In vitro assays showed that Sporothrix schenckii sensu stricto and S. brasiliensis yeast clinical isolates were susceptible to low concentrations of P-AMB and D-AMB...
June 1, 2017: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/28566662/practical-management-of-deep-cutaneous-fungal-infections
#6
Tomotaka Sato
Understanding deep cutaneous fungal infection requires not only reading many case reports and checking the typical clinical images of skin lesions, but also managing the patients properly to prevent misdiagnosis. Herein, I review my recent experiences with eight typical cases of deep cutaneous infections (including protothecosis and nocardiosis) in Japan. It is very important to do the four management processes; namely, KOH direct microscopic examination, skin biopsy, fungal culture, and microscopic examination of the histopathological specimen of PAS and Grocott staining...
2017: Medical Mycology Journal
https://www.readbyqxmd.com/read/28539922/sporothrix-schenckii-sensu-stricto-and-sporothrix-brasiliensis-are-differentially-recognized-by-human-peripheral-blood-mononuclear-cells
#7
José A Martínez-Álvarez, Luis A Pérez-García, Erika Mellado-Mojica, Mercedes G López, Iván Martínez-Duncker, Leila M Lópes-Bezerra, Héctor M Mora-Montes
Sporothrix schenckii sensu stricto and S. brasiliensis are usually associated to sporotrichosis, a subcutaneous mycosis worldwide distributed. Comparative analyses between these two species indicate they contain genetic and physiological differences that are likely to impact the interaction with host cells. Here, we study the composition of the cell wall from conidia, yeast-like cells and germlings of both species and found they contained the same sugar composition. The carbohydrate proportion in the S. schenckii sensu stricto wall was similar across the three cell morphologies, with exception in the chitin content, which was significantly different in the three morphologies...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28492800/fungal-infection-control-by-garlic-extracts-allium-sativum-l-and-modulation-of-peritoneal-macrophages-activity-in-murine-model-of-sporotrichosis
#8
J P Burian, L V S Sacramento, I Z Carlos
Garlic (Allium sativum L.) is grown all over the world as seasoning and medicinal vegetable since 3,000 BC. Allicin is the main component of garlic, being attributed to it the most of its biological activities, such as bactericidal, antifungal and antiviral actions. However, other compounds of garlic present antioxidant, hypocholesterolemic, vasodilator activities, protective action against different types of cancer, and immunomodulatory. Fungal infections are important causes of morbidity and mortality in people mainly in immunosuppressed ones...
May 4, 2017: Brazilian Journal of Biology, Revista Brasleira de Biologia
https://www.readbyqxmd.com/read/28488313/sporotrichosis-among-children-of-a-hyperendemic-area-in-peru-an-8-year-retrospective-study
#9
Max C Ramírez Soto
BACKGROUND: The clinical and epidemiologic characteristics of pediatric sporotrichosis are poorly understood. OBJECTIVE: To describe the incidence and clinical characteristics of cases of sporotrichosis in children 14 years of age and younger reported in Abancay from 2004 to 2011, stratified according to age. METHODS: We performed a retrospective review of pediatric patients 14 years of age and younger who were diagnosed with sporotrichosis in a referral center at Abancay, a poor area located in the south central highlands of Peru, to estimate the incidence rates (per 100,000 person-years) according to age and sporotrichosis type (lymphocutaneous and fixed), and clinical characteristics of these patients...
May 9, 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/28482071/polar-origanum-vulgare-lamiaceae-extracts-with-antifungal-potential-against-sporothrix-brasiliensis
#10
Stefanie Bressan Waller, Jéssica Fernanda Hoffmann, Isabel Martins Madrid, Tony Picoli, Marlete Brum Cleff, Fabio Clasen Chaves, Régis A Zanette, João Roberto Braga de Mello, Renata Osório de Faria, Mário Carlos Araújo Meireles
Oregano (Origanum vulgare) has anti-Sporothrix spp. activity, including against strains that are resistant to antifungal drugs. As the studies are limited to the essential oil, the aim of this study was to evaluate the chemical, antioxidant and cytotoxic properties of polar oregano extracts and their anti-Sporothrix brasiliensis activity. Aerial plant parts were used in the preparation of 10 min (INF10) and 60 min (INF60) infusions, a decoction (DEC) and a hydroalcoholic extract (HAE). Six phenolic acids and four flavonoids were identified and quantified through liquid-chromatography (LC-MS)...
May 6, 2017: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/28472490/in-vitro-susceptibility-of-sporothrix-brasiliensis-comparison-of-yeast-and-mycelial-phases
#11
Karine Ortiz Sanchotene, Tchana Martinez Brandolt, Gabriel Baracy Klafke, Vanice Rodrigues Poester, Melissa Orzechowski Xavier
Sporothrix brasiliensis has emerged as an important cause of sporotrichosis, particularly associated with feline and zoonotic cases. Owing to the paucity of data on antifungal activity against this species, the present study aimed to evaluate the in vitro susceptibility of clinical isolates of S. brasiliensis in the mycelial and yeast phases to itraconazole (ITZ), terbinafine (TRB), and amphotericin B (AMB). Thirty-five isolates from an outbreak of feline sporotrichosis in Southern Brazil were used. All of them were assessed in the yeast and filamentous phases using the broth microdilution technique in accordance with the respective reference protocols M27-A3 and M38-A2 of the Clinical and Laboratory Standards Institute (CLSI)...
May 4, 2017: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/28443986/minimal-inhibitory-concentration-distributions-and-epidemiological-cutoff-values-of-five-antifungal-agents-against-sporothrix-brasiliensis
#12
Rodrigo Almeida-Paes, Fábio Brito-Santos, Maria Helena Galdino Figueiredo-Carvalho, Ana Caroline Sá Machado, Manoel Marques Evangelista Oliveira, Sandro Antonio Pereira, Maria Clara Gutierrez-Galhardo, Rosely Maria Zancopé-Oliveira
BACKGROUND: Sporothrix brasiliensis is the most virulent sporotrichosis agent. This species usually responds to antifungal drugs, but therapeutic failure can occur in some patients. Antifungal susceptibility tests have been performed on this species, but no clinical breakpoints (CBPs) are available. In this situation, minimal inhibitory concentration (MIC) distributions and epidemiological cutoff values (ECVs) support the detection of identification of resistant strains. OBJECTIVES: To study the MIC distributions of five antifungal drugs against S...
May 2017: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/28427354/unique-case-report-of-a-chromomycosis-and-listeria-in-soft-tissue-and-cerebellar-abscesses-after-kidney-transplantation
#13
J Tourret, N Benabdellah, S Drouin, F Charlotte, J Rottembourg, N Arzouk, A Fekkar, B Barrou
BACKGROUND: Chromomycosis is a rare mycotic infection encountered in tropical and subtropical regions. The disease presents as a slowly-evolving nodule that can become infected with bacteria. Here, we describe a unique association of abscesses caused by a chromomycosis and Listeria monocytogenes in a kidney transplant recipient, and didactically expose how the appropriate diagnosis was reached. CASE PRESENTATION: A 49-year old male originating from the Caribbean presented a scalp lesion which was surgically removed in his hometown where it was misdiagnosed as a sporotrichosis on histology, 3 years after he received a kidney transplant...
April 20, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28380215/recombinant-60-kda-heat-shock-protein-from-paracoccidioides-brasiliensis-is-it-a-good-antigen-for-serological-diagnosis-of-paracoccidioidomycosis
#14
G Peron, F F Fernandes, T N Landgraf, R Martinez, A Panunto-Castelo
Paracoccidioides brasiliensis and P. lutzii are fungi that cause paracoccidioidomycosis (PCM), the most prevalent systemic mycosis in South America. For serological diagnosis, although 43-kDa glycoprotein (gp43) is regarded as highly specific for PCM, the occurrence of false negative reactions in sera from patients infected with P. lutzii suggests that preparation with only one antigen is not recommended. Heat shock proteins are feasible alternatives as a second antigen because they are often highly immunogenic...
April 3, 2017: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/28349410/disseminated-sporotrichosis-with-osteolytic-bone-involvement
#15
Paul B Aronowitz, Meghan Gilroy, Katerina N Christiansen
No abstract text is available yet for this article.
March 27, 2017: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/28327256/origin-and-distribution-of-sporothrix-globosa-causing-sapronoses-in-asia
#16
REVIEW
Tarek A A Moussa, Naif M S Kadasa, Hassan S Al Zahrani, Sarah Abdallah Ahmed, Peiying Feng, Albertus H G Gerrits van den Ende, Yu Zhang, Rui Kano, Fuqiu Li, Shanshan Li, Yang Song, Bilin Dong, Luana Rossato, Somayeh Dolatabadi, Sybren de Hoog
PURPOSE: The aim of the study was to evaluate the main sources and epidemiological patterns and speculate on the evolutionary origin of Sporothrix globosa in Asia. METHODOLOGY: Case and case series literature on sporotrichosis in Asia from January 2007 onwards were reviewed using meta-analysis. Phylogenetic analysis of relevant S. globosa was carried out on the basis of concatenated sequences of ITS, TEF3 and CAL. A haplotype network of CAL sequences of 281 Sporothrix isolates was analysed to determine the population structure of S...
May 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28316596/the-efficacy-of-humanized-antibody-against-the-sporothrix-antigen-gp70-in-promoting-phagocytosis-and-reducing-disease-burden
#17
José R F de Almeida, Karla L Santiago, Gilberto H Kaihami, Andrea Q Maranhão, Marcelo de Macedo Brígido, Sandro R de Almeida
Sporotrichosis is a subcutaneous mycosis distributed worldwide and is frequently reported in countries with tropical climates, as Latin America countries. We previously demonstrated that mice with sporotrichosis produce specific antibodies against a 70-kDa fungal protein, indicating that specific antibodies against this molecule may help to control the sporotrichosis. IgG1 monoclonal antibody was generated, and called mAbP6E7, in mice against a 70-kDa glycoprotein (gp70) of S. schenckii. The mAbP6E7 showed prophylactic and therapeutic activity against sporotrichosis...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28286151/oxidative-stress-in-rats-experimentally-infected-by-sporothrix-schenckii
#18
Verônica S P Castro, Aleksandro S Da Silva, Gustavo R Thomé, Patrícia Wolkmer, Jorge L C Castro, Márcio M Costa, Dominguita L Graça, Daniele C Oliveira, Sydney H Alves, Maria R C Schetinger, Sonia T A Lopes, Lenita M Stefani, Maria I Azevedo, Matheus D Baldissera, Cinthia M Andrade
The aim of this study was to evaluate whether oxidative stress occurs in rats experimentally infected by Sporothrix schenckii, and its possible effect on disease pathogenesis. Thirty rats were divided into two groups: the group A (uninfected, n = 18) and the group B (infected by S. schenckii, n=21). Blood samples were collected on days 15, 30 and 40 post-infection (PI). At each sampling time, six rats of the group A, and seven of the group B were bled. TBARS (thiobarbituric acid reactive substances) levels in serum samples were measured to evaluate lipid peroxidation...
March 7, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28219829/chemical-and-cytotoxic-analyses-of-brown-brazilian-propolis-apis%C3%A2-mellifera-and-its-in%C3%A2-vitro-activity-against-itraconazole-resistant%C3%A2-sporothrix-brasiliensis
#19
Stefanie B Waller, Cristina M Peter, Jéssica F Hoffmann, Tony Picoli, Luiza da G Osório, Fábio Chaves, João L Zani, Renata O de Faria, João R B de Mello, Mário C A Meireles
This study aimed to evaluate the chemical composition and cytotoxic activity of brown Brazilian propolis and its in vitro activity against itraconazole-resistant Sporothrix brasiliensis from animal sporotrichosis. Propolis was acquired commercially and prepared as a hydroalcoholic extract. Chemical analysis was evaluated by liquid chromatography coupled to mass spectrometry of ultra-efficiency. The cell viability was evaluated by MTT test in MDBK cells of 50 to 0.09 μg/mL. For antifungal tests, twenty isolates of Sporothrix brasiliensis from dogs (n = 11) and cats (n = 9) with sporotrichosis were tested to itraconazole (16-0...
April 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28140444/the-nlrp3-inflammasome-contributes-to-host-protection-during-sporothrix-schenckii-infection
#20
Amanda Costa Gonçalves, Lucas Souza Ferreira, Francine Alessandra Manente, Carolina Maria Quinello Gomes de Faria, Marisa Campos Polesi, Cleverton Roberto de Andrade, Dario Simões Zamboni, Iracilda Zeppone Carlos
Sporotrichosis is a mycosis caused by fungi from the Sporothrix schenckii species complex, whose prototypical member is Sporothrix schenckii sensu stricto. Pattern recognition receptors (PRRs) recognize and respond to pathogen-associated molecular patterns (PAMPs) and shape the following adaptive immune response. A family of PRRs most frequently associated with fungal recognition is the nucleotide-binding oligomerization domain-like receptor (NLR). After PAMP recognition, NLR family pyrin domain-containing 3 (NLRP3) binds to apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC) and caspase-1 to form the NLRP3 inflammasome...
June 2017: Immunology
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