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https://www.readbyqxmd.com/read/29033611/stable-ischemic-heart-disease-in-women-current-perspectives
#1
REVIEW
Fatima Samad, Anushree Agarwal, Zainab Samad
Cardiovascular disease is the leading cause of death in women accounting for 1 in every 4 female deaths. Pathophysiology of ischemic heart disease in women includes epicardial coronary artery, endothelial dysfunction, coronary vasospasm, plaque erosion and spontaneous coronary artery dissection. Angina is the most common presentation of stable ischemic heart disease (SIHD) in women. Risk factors for SIHD include traditional risks such as older age, obesity (body mass index [BMI] >25 kg/m(2)), smoking, hypertension, dyslipidemia, cerebrovascular and peripheral vascular disease, sedentary lifestyle, family history of premature coronary artery disease, metabolic syndrome and diabetes mellitus, and nontraditional risk factors, such as gestational diabetes, insulin resistance/polycystic ovarian disease, pregnancy-induced hypertension, pre-eclampsia, eclampsia, menopause, mental stress and autoimmune diseases...
2017: International Journal of Women's Health
https://www.readbyqxmd.com/read/29030996/re-examining-the-sensitivity-of-glycated-hemoglobin-to-screen-for-diabetes-mellitus
#2
Chun Wei Yap, Yee Gary Ang, Timothy Peng Lim Quek, Bee Hoon Heng, Daniel Ek Kwang Chew
BACKGROUND: Glycated hemoglobin (HbA1c) is one of the laboratory tests recommended by the ADA to screen for diabetes mellitus (DM). It is particularly suitable for population segments that cannot or are unwilling to fast for a screening test. Our study aims to determine if HbA1c would be a useful tool to screen for DM in a real world setting if ADA guidelines for repeat testing to confirm the diagnosis of DM are strictly adhered to. METHODS: We carried out a retrospective database study by extracting demographic and laboratory data from a chronic disease registry which collects data on adults from three tertiary hospitals and nine large primary care clinics in Singapore...
October 14, 2017: Journal of Diabetes
https://www.readbyqxmd.com/read/29026763/comparative-evaluation-of-indian-diabetes-risk-score-and-finnish-diabetes-risk-score-for-predicting-risk-of-diabetes-mellitus-type-ii-a-teaching-hospital-based-survey-in-maharashtra
#3
Shivshakti D Pawar, Jayashri D Naik, Priya Prabhu, Gajanan M Jatti, Sachin B Jadhav, B K Radhe
CONTEXT: India is currently becoming capital for diabetes mellitus. This significantly increasing incidence of diabetes putting an additional burden on health care in India. Unfortunately, half of diabetic individuals are unknown about their diabetic status. Hence, there is an emergent need of effective screening instrument to identify "diabetes risk" individuals. AIMS: The aim is to evaluate and compare the diagnostic accuracy and clinical utility of Indian Diabetes Risk Score (IDRS) and Finnish Diabetes Risk Score (FINDRISC)...
January 2017: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/29020962/manipulation-under-anesthesia-versus-physiotherapy-treatment-in-stage-two-of-a-frozen-shoulder-a-study-protocol-for-a-randomized-controlled-trial
#4
Tim Kraal, Bertram The, Ronald Boer, M P van den Borne, Koen Koenraadt, Pjotr Goossens, Denise Eygendaal
BACKGROUND: There is no consensus about the optimal treatment strategy for frozen shoulders (FS). Conservative treatment consisting of intra-articular corticosteroid infiltrations and physiotherapy are considered appropriate for most patients. However, with a conservative strategy, patients experience a prolonged rehabilitation period with a considerable amount of pain and disabilities in daily life. Also, at long term, a residual amount of pain and restriction of range of motion is frequently reported...
October 11, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28993341/insights-from-molecular-characterization-of-adult-patients-of-families-with-multigenerational-diabetes-mellitus
#5
Serena Pezzilli, Ornella Ludovico, Tommaso Biagini, Luana Mercuri, Federica Alberico, Eleonora Lauricella, Hamza Dallali, Daniele Capocefalo, Massimo Carella, Elide Miccinilli, Pamela Piscitelli, Maria Giovanna Scarale, Tommaso Mazza, Vincenzo Trischitta, Sabrina Prudente
Multigenerational diabetes of the adulthood is a mostly overlooked entity, simplistically comprised in the large basin of type 2 diabetes. The general aim we are pursuing in last years is to unravel the genetic causes of such form of diabetes. Identifying among families with multigenerational diabetes those carrying mutations in known monogenic diabetes genes is the first step to then concentrate on remaining pedigrees where to unravel new diabetogenes.Targeted Next Generation Sequencing of 27 monogenic diabetes-genes has been carried out in 55 family probands and identified mutations verified among their relatives by Sanger sequencing...
October 9, 2017: Diabetes
https://www.readbyqxmd.com/read/28990943/-do-turkish-reimbursement-recommendations-cover-current-european-lipid-guidelines-a-retrospective-analysis-of-patients-presenting-with-first-acute-coronary-syndrom
#6
Deniz Demirci, Duygu Ersan Demirci, Murat Esin, Özkan Kayhan, Şakir Arslan
OBJECTIVE: This study was a comparison of the statin therapy protocol issued by the European Society of Cardiology (ESC) and the Ministry of Health's Health Implementation Directive (SUT) in Turkey, performed in order to assess the adequacy of hyperlipidemia treatment indications for primary prevention. METHODS: A total of 582 patients with first acute coronary syndrome were included in the study. Patients with noncritical stenosis observed on coronary angiography or a history of atherosclerotic disease were excluded...
October 2017: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
https://www.readbyqxmd.com/read/28990741/post-transplant-diabetes-diagnosis-and-management
#7
Brian P Boerner, Vijay Shivaswamy, Eric Wolatz, Jennifer Larsen
Post-transplant diabetes mellitus (PTDM) is common after most types of solid organ transplantation, though the actual incidence is as yet unknown because of the use of different diagnostic criteria. PTDM is the result of individual risk factors as well as risk factors associated with the transplant itself, particularly immunosuppressants. Previously called New Onset Diabetes, in many cases inadequate screening for diabetes before transplant cannot assure that the diabetes is new after transplant. The most recent international consensus guidelines suggest diagnosis should be delayed until the patient is taking maintenance doses of immunosuppressants even if they require treatment in the immediate hospitalization...
October 9, 2017: Minerva Endocrinologica
https://www.readbyqxmd.com/read/28967720/current-multivariate-risk-scores-in-patients-undergoing-non-cardiac-surgery
#8
Gian Francesco Mureddu
Several indexes to predict perioperative cardiovascular risk have been proposed overtime. The most widely used is the Revised Cardiac Risk Index (RCRI) developed by Lee since 1999. It predicts major cardiac outcomes from five independent clinical determinants: history of ischemic heart disease, history of cardiovascular disease, heart failure, insulin-dependent diabetes mellitus, and chronic renal failure (i.e. serum creatinine >2 mg/dl). In external validation studies, the RCRI showed high negative predictive value in all groups of age, indicating that it may be used to identify people at low risk for perioperative adverse cardiovascular events in noncardiac surgery...
July 18, 2017: Monaldi Archives for Chest Disease, Archivio Monaldi Per le Malattie del Torace
https://www.readbyqxmd.com/read/28957985/evidence-supporting-serology-based-pathway-for-diagnosing-coeliac-disease-in-asymptomatic-children-from-high-risk-groups
#9
Siba Prosad Paul, Bhupinder Kaur Sandhu, Christine Helen Spray, Dharamveer Basude, Pramila Ramani
OBJECTIVE: The European Society for Paediatric Gastroenterology Hepatology and Nutrition (ESPGHAN) guidelines for diagnosing coeliac disease (CD) in children were modified in 2012. They recommend that in symptomatic children with anti-tissue transglutaminase antibody (anti-tTG) titre of greater than 10-times upper limit of normal (>10xULN) and who have positive anti-endomysial antibody and HLA-DQ2/DQ8 haplotype, the diagnosis of CD can be based on serology. Aim of this study is to establish whether serology-based pathway of the ESPGHAN guidelines could also be reliably applied to asymptomatic children from high-risk groups...
September 27, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28956359/metabolic-surgery-in-korea-what-to-consider-before-surgery
#10
REVIEW
Mi Kyung Kim, Yoonseok Heo
Obesity is increasing globally and represents a significant global health problem because it predisposes towards various diseases, such as type 2 diabetes mellitus, cardiovascular disease, degenerative joint disease, and certain types of cancer. Numerous studies have shown that bariatric surgery reduces body mass and ameliorates obesity-related complications, such as hypertension and hyperglycemia, suggesting that surgery is the most effective therapeutic option for severely obese and obese diabetic patients...
September 2017: Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28955417/prescription-pattern-of-antihypertensive-medications-and-blood-pressure-control-among-hypertensive-outpatients-at-the-university-of-benin-teaching-hospital-in-benin-city-nigeria
#11
Oluseyi Adejumo, Enajite Okaka, Ikponmwosa Iyawe
BACKGROUND: The prevalence of hypertension and attendant cardiovascular disease burden is increasing globally. Auditing antihypertensive prescriptions and assessing patients with hypertension for blood pressure (BP) control are important steps on the path to reducing hypertension-related morbidity, mortality, and health expenditure. This study assessed the prescription pattern of antihypertensive medications and BP control among hypertensive outpatients at the University of Benin Teaching Hospital in Benin City, Nigeria...
June 2017: Malawi Medical Journal: the Journal of Medical Association of Malawi
https://www.readbyqxmd.com/read/28952815/blood-pressure-goal-for-the-elderly-chinese-the-findings-from-the-northern-shanghai-study
#12
Jiadela Teliewubai, Bin Qiu, Yuyan Lu, Bin Bai, Shikai Yu, Yiwu Zhou, Chen Chi, Jing Xiong, Hongwei Ji, Ximin Fan, Jue Li, Jacques Blacher, Yawei Xu, Yi Zhang
BACKGROUND: The Eighth Joint National Committee Panel (JNC8) recommended a novel blood pressure (BP) goal for individuals with hypertension, which was less stringent than the Seventh Joint National Committee (JNC7) guideline and is still under debate. In our study, we aimed at finding a better BP goal for the elderly Chinese. METHODS: About 1599 community-based elderly participants were recruited in the northern Shanghai and were classified by chronic kidney disease or diabetes mellitus to investigate their BP control conditions based on both the JNC7 and JNC8...
September 27, 2017: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/28951682/clinical-pharmacists-as-medication-therapy-experts-in-diabetic-clinics-in-saudi-arabia-not-just-a-perception-but-a-need
#13
REVIEW
Hafiz A Makeen
The pharmacist's role is expanding from medication dispensing to patient care. There are several newer horizons in which clinical pharmacists have a vital role to play such as diabetic care, handling asthma patients, pain management, anti-coagulation therapy and in hyperlipidemia. Among these, the disorder that is perceived to reach epidemic proportions globally is diabetes mellitus. In the Arab world, particularly in countries like Saudi Arabia, the number affected and the cost incurred in the management of diabetes are relatively high...
September 2017: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/28948654/quality-assessment-of-recent-evidence-based-clinical-practice-guidelines-for-management-of-type-2-diabetes-mellitus-in-adults-using-the-agree-ii-instrument
#14
Muhammad A Anwer, Ousama B Al-Fahed, Samir I Arif, Yasser S Amer, Maher A Titi, Mohammed O Al-Rukban
RATIONALE, AIMS AND OBJECTIVES: Type 2 diabetes mellitus (T2DM) is a worldwide and national public health problem that has a great impact on the population in Saudi Arabia. High-quality clinical practice guidelines (CPGs) are cornerstones in improving the health care provided for patients with diabetes. This study evaluated the methodological rigour, transparency, and applicability of recently published CPGs. METHODS: Our group conducted a systematic search for recently published CPGs for T2DM...
September 25, 2017: Journal of Evaluation in Clinical Practice
https://www.readbyqxmd.com/read/28943985/the-impact-of-pharmacist-led-medication-therapy-management-on-medication-adherence-in-patients-with-type-2-diabetes-mellitus-a-randomized-controlled-study
#15
Daniel A Erku, Asnakew A Ayele, Abebe B Mekuria, Sewunet A Belachew, Bisrat Hailemeskel, Henok G Tegegn
BACKGROUND: Poor adherence to antidiabetic medications leads to a higher rate of hospital admissions and adverse health outcomes in type 2 diabetes mellitus patients. OBJECTIVE: This study aims to evaluate whether a pharmacist-led medication therapy management, compared to the usual care, could enhance medication adherence and reduce hospital admission in patients with type 2 diabetes mellitus. METHODS: A prospective randomized controlled study was conducted in patients with type 2 diabetes mellitus from February 1 to July 30, 2016...
July 2017: Pharmacy Practice
https://www.readbyqxmd.com/read/28940961/perioperative-continuation-of-metformin-does-not-improve-glycemic-control-in-patients-with-type-2-diabetes-a-randomized-controlled-trial
#16
A H Hulst, J A W Polderman, E Ouweneel, A J Pijl, M W Hollmann, J H DeVries, B Preckel, J Hermanides
Historically, metformin was withheld before surgery in fear of metformin associated lactic acidosis. Now, this risk is deemed low and guidelines move towards continuation of metformin. We hypothesized that continuing metformin perioperatively would lower postoperative serum glucose without an effect on plasma lactate. We performed a single-blind multicenter RCT in type 2 diabetes mellitus patients scheduled for non-cardiac surgery and continued (MF+) or withheld (MF-) metformin before surgery. Main outcome parameters were the differences in perioperative plasma glucose and lactate levels...
September 20, 2017: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/28939944/gestational-retinal-microvasculature-and-the-risk-of-5%C3%A2-year-postpartum-abnormal-glucose-metabolism
#17
Ling-Jun Li, Kok Hian Tan, Izzuddin M Aris, Yap Seng Chong, Seang Mei Saw, Peter Gluckman, Jie Jin Wang, Tien Yin Wong
AIMS/HYPOTHESIS: Changes in retinal microvasculature may reflect insulin resistance. We examined the association of changes in retinal microvasculature during pregnancy and risk of subsequent abnormal glucose metabolism in a cohort of mothers at baseline and 5 years postpartum. METHODS: Of the participants from the Singapore birth cohort (Growing Up in Singapore Towards Healthy Outcomes [GUSTO]), 276 mothers attended both baseline (at 26-28 weeks of gestation) and follow-up (5 year postpartum) visits...
September 22, 2017: Diabetologia
https://www.readbyqxmd.com/read/28937255/the-assessment-of-the-serum-c-peptide-and-plasma-glucose-levels-by-orally-administered-whey-proteins-in-type-2-diabetes-mellitus
#18
E Wildová, P Kraml, J Potočková, P Dlouhý, M Anděl
A personalized antidiabetic therapy is not yet part of the official guidelines of professional societies for clinical practice. The aim of this study was to evaluate the serum C-peptide and plasma glucose levels in patients with type 2 diabetes mellitus (T2DM) after oral administration of whey proteins. Sixteen overweight T2DM Caucasians with good glycaemic control and with preserved fasting serum C-peptide levels (> 200 nmol/l) were enrolled in this study. Two oral stimulation tests - one with 75 g of glucose (OGTT) and the other with 75 g of whey proteins (OWIST) - were administered for assessing serum C-peptide and plasma glucose levels in each participant...
September 22, 2017: Physiological Research
https://www.readbyqxmd.com/read/28936150/prevalence-of-poor-glycemic-and-blood-pressure-control-and-pattern-of-drug-use-among-primary-health-care-outpatients-in-al-ahsa-saudi-arabia
#19
Promise M Emeka, Ahmed Al Mukalaf, Hussien Al Helal, Tahir M Khan, Mishial A Almukalf
OBJECTIVES: To assess drug use pattern and the effect on glycemic and blood pressure (BP) control in type 2 diabetes mellitus (T2DM) and hypertensive patients. Furthermore, to evaluate the duration of drug use and antecedence in diagnosis. METHODOLOGY: A cross-sectional study design, comprising interview/questionnaire targeting outpatients attending primary health centers in Al Ahsa was adopted. During the interview, their fasting blood glucose, weight, and height were measured, along with their BP...
July 2017: International Journal of Health Sciences
https://www.readbyqxmd.com/read/28934715/stercoral-perforation-of-the-rectosigmoid-colon-due-to-chronic-constipation-a-case-report
#20
Mustafa Fevzi Celayir, Hakan Mustafa Köksal, Mehmet Uludag
INTRODUCTION: Chronic constipation is very common in elderly patients. As a result of this situation fecaloma is also frequently seen at these ages. However, the stercoral perforation caused by fecaloma is a rare situation to occur. The rectosigmoid colon is the most affected colonic segment. It is seen in older patients with concomitant diseases and a low quality of life. PRESENTATION OF CASE: Here in this case, we have to report an 83 - year-old male patient who came to the emergency room with complaints of abdominal pain and constipation for two days...
September 14, 2017: International Journal of Surgery Case Reports
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