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https://www.readbyqxmd.com/read/29449295/management-of-type-2-diabetes-mellitus-in-people-with-severe-mental-illness-an-online-cross-sectional-survey-of-healthcare-professionals
#1
Hayley McBain, Frederique Lamontagne-Godwin, Mark Haddad, Alan Simpson, Jacqui Chapman, Julia Jones, Chris Flood, Kathleen Mulligan
OBJECTIVES: To establish healthcare professionals' (HCPs) views about clinical roles, and the barriers and enablers to delivery of diabetes care for people with severe mental illness (SMI). DESIGN: Cross-sectional, postal and online survey. SETTING: Trusts within the National Health Service, mental health and diabetes charities, and professional bodies. PARTICIPANTS: HCPs who care for people with type 2 diabetes mellitus (T2DM) and/or SMI in the UK...
February 15, 2018: BMJ Open
https://www.readbyqxmd.com/read/29448285/-risk-factors-and-therapeutic-goals-for-primary-and-secondary-cardiovascular-prevention-significance-for-the-glaucoma-patient
#2
Claudia Hacke, Carl Erb, Burkhard Weisser
Hypertension, diabetes mellitus and dyslipidaemia are among the most important cardiovascular risk factors. In addition, there is an association with the development and progression of glaucoma. During the last years, there has been an intense discussion concerning optimal treatment goals for these risk factors. Recently, the American Heart Association has defined a blood pressure greater than 130/80 mmHg as hypertension and the European guidelines will follow this definition. These lower blood pressure limits increase the risk for a too strict blood pressure treatment with night values, which might be too low for glaucoma patients...
February 2018: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/29446529/educational-disparities-in-the-associations-between-self-monitoring-of-blood-glucose-and-glycemic-control-in-type-2-diabetes-patients-in-xiamen-china
#3
Yanbing Zeng, Jielong Wu, Yaofeng Han, Fan Chen, Lele Chen, Shuyu Yang, Ya Fang
BACKGROUND: To examine the combined effect of self-monitoring of blood glucose (SMBG) and educational attainment on glycemic control in type 2 diabetes mellitus (T2DM) patients. METHODS: A cross-sectional survey was performed among community residents with T2DM. Good glycemic control was defined as hemoglobin A1c (HbA1c) levels below 7% in the most recent measurement. Multivariable logistic regression was used to examine associations of glycemic control with SMBG, educational attainment, and their combined effects by controlling for certain covariates, with further stratification by sex...
February 15, 2018: Journal of Diabetes
https://www.readbyqxmd.com/read/29444890/effect-of-gestational-diabetes-and-hypertensive-disorders-of-pregnancy-on-postpartum-cardiometabolic-risk
#4
Ling-Jun Li, Izzuddin M Aris, Lin Lin Su, Yap Seng Chong, Tien Yin Wong, Kok Hian Tan, Jie Jin Wang
AIMS: The cumulative effect of gestational diabetes mellitus (GDM) and hypertensive disorders of pregnancy (HDP) on postpartum cardio-metabolic diseases is equivocal. We aimed to assess the associations of GDM and HDP's individual and synergic contribution to risks of postpartum cardio-metabolic diseases (metabolic syndrome (MetS), abnormal glucose metabolism and hypertension (HTN)). METHODS: Of participants from a Singapore birth cohort, 276 mothers attending the 5-year postpartum visit were included in this study...
February 14, 2018: Endocrine Connections
https://www.readbyqxmd.com/read/29441829/role-of-peroxisome-proliferator-activated-receptor-gamma-activation-on-visfatin-advanced-glycation-end-products-and-renal-oxidative-stress-in-obesity-induced-type-2-diabetes-mellitus
#5
A Tabassum, T Mahboob
The present study focused on the role of peroxisome proliferator-activated receptor-gamma (PPAR-γ) activation on renal oxidative damages, serum visfatin, and advanced glycation end products (AGEs) in high-fat diet (HFD)-induced type 2 diabetes mellitus. Following the institutional animal ethics committee guidelines, Wistar rats were categorized into five groups: group 1: fed on a normal rat diet; group 2: HFD-induced obese rats (HFD for 8 weeks); group 3: HFD-fed rats treated with rosiglitazone (RSG; 3 mg/kg orally for 7 days); group 4: T2DM rats induced by HFD and low dose of streptozotocin (i...
January 1, 2018: Human & Experimental Toxicology
https://www.readbyqxmd.com/read/29431385/glucose-management-in-hospitalized-patients
#6
Charles Kodner, Laurie Anderson, Katherine Pohlgeers
Glucose management in hospitalized patients poses challenges to physicians, including identifying blood glucose targets, judicious use of oral diabetes mellitus medications, and implementing appropriate insulin regimens. Uncontrolled blood glucose levels can lead to deleterious effects on wound healing, increased risk of infection, and delays in surgical procedures or discharge from the hospital. Previously recommended strict blood glucose targets for hospitalized patients result in more cases of hypoglycemia without improvement in patient outcomes...
November 15, 2017: American Family Physician
https://www.readbyqxmd.com/read/29431364/chronic-kidney-disease-detection-and-evaluation
#7
David Y Gaitonde, David L Cook, Ian M Rivera
Chronic kidney disease affects 47 million people in the United States and is associated with significant health care costs, morbidity, and mortality. Because this disease can silently progress to advanced stages, early detection is critical for initiating timely interventions. Multiple guidelines recommend at least annual screening with serum creatinine, urine albumin/creatinine ratio, and urinalysis for patients with risk factors, particularly diabetes mellitus, hypertension, and a history of cardiovascular disease...
December 15, 2017: American Family Physician
https://www.readbyqxmd.com/read/29429439/clinical-characteristics-and-causes-of-heart-failure-adherence-to-treatment-guidelines-and-mortality-of-patients-with-acute-heart-failure-experience-at-groote-schuur-hospital-cape-town-south-africa
#8
P Z Szymanski, M Badri, B M Mayosi
BACKGROUND: There is limited information on acute heart failure (AHF) and its treatment in sub-Saharan Africa. OBJECTIVE: To describe the clinical characteristics and causes of heart failure (HF), adherence to HF treatment guidelines, and mortality of patients with AHF presenting to Groote Schuur Hospital (GSH), Cape Town, South Africa. METHODS: This sub-study of The Sub-Saharan Africa Survey of Heart Failure (THESUS-HF) was a prospective and observational survey that focused on the enrolment and follow-up of additional patients with AHF presenting to GSH and entered into the existing registry after publication of the primary THESUS-HF article in 2012...
February 1, 2018: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
https://www.readbyqxmd.com/read/29425107/screening-for-gestational-diabetes-in-low-risk-women-effect-of-maternal-age
#9
Aida Kalok, Pravin Peraba, Shamsul Azhar Shah, Zaleha Abdullah Mahdy, Mohamad Abdul Jamil, Nirmala Kampan, Suraya Sulaiman, Nor Azlin Mohamed Ismail
Background Gestational diabetes mellitus (GDM) is on the rise globally and there are various screening guidelines with regard to patients' criteria. Materials and methods We conducted a prospective cross-sectional study to determine the prevalence of GDM amongst low-risk pregnant women above the age of 25 years. A modified glucose tolerance test (MGTT) was performed between 24 and 36 weeks of gestation. Women with GDM were divided into two groups for analysis: age between 25 and 34 years (group A) and above 35 years (group B)...
February 9, 2018: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/29424469/effect-of-intensive-blood-pressure-control-in-patients-with-type-2-diabetes-mellitus-over-9-years-of-follow-up-a-subgroup-analysis-of-high-risk-accordion-trial-participants
#10
Leo F Buckley, Dave L Dixon, George F Wohlford, Dayanjan S Wijesinghe, William L Baker, Benjamin W Van Tassell
Although guidelines recommend strict blood pressure (BP) control in patients with type 2 diabetes mellitus (T2DM) and elevated cardiovascular risk, the long-term effects of this approach are unknown. We investigated the effect of intensive BP control on clinical outcomes in patients with T2DM over 9 years of follow-up. We included ACCORD BP participants in the standard glucose control arm who had established cardiovascular disease, chronic kidney disease, age ≥75 years or 10-year coronary heart risk ≥15%...
February 9, 2018: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/29417379/a-snapshot-of-type-two-diabetes-mellitus-management-in-general-practice-prior-to-the-introduction-of-diabetes-cycle-of-care
#11
Jennifer V Gettings, Raymond O'Connor, Jane O'Doherty, Ailish Hannigan, Walter Cullen, Louise Hickey, Andrew O'Regan
BACKGROUND: Diabetes is associated with complications, including coronary heart disease, stroke, kidney failure, blindness and amputation, and ultimately is a major cause of disability and death worldwide. Adherence to best practice guidelines is limited in unstructured diabetes management in primary care settings. AIMS: This study aims to establish what data was being collected in general practice prior to the introduction of the Cycle of Care, which is a proactive model of diabetes management introduced in Ireland...
February 7, 2018: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/29415658/late-onset-postoperative-mycobacterium-haemophilum-endophthalmitis-masquerading-as-inflammatory-uveitis-a-case-report
#12
Warinyupa Pinitpuwadol, Sucheera Sarunket, Sutasinee Boonsopon, Nattaporn Tesavibul, Pitipol Choopong
BACKGROUND: Although atypical mycobacteria had been increasingly found in various ocular infections in the past decades, a slow-growing Mycobacterium haemophilum (M. haemophilum) was scarcely reported. Similar to tuberculous infection, the presentation can masquerade as low-grade granulomatous intraocular inflammation with partial response to corticosteroids. Besides, the special requirements for culture make this pathogen difficult to diagnose. The study aims to report the clinical presentation and notify the awareness of NTM endophthalmitis among clinicians...
February 7, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29413998/lipid-lowering-treatment-in-peripheral-artery-disease
#13
REVIEW
Niki Katsiki, Athanasios D Giannoukas, Vasilios G Athyros, Dimitri P Mikhailidis
Peripheral artery disease (PAD) is characterized by increased cardiovascular (CV) risk, limb morbidity and all-cause mortality. According to the current guidelines (2016) of the American Heart Association/American College of Cardiology on the management of PAD patients, statin therapy is recommended for PAD patients in order to treat dyslipidemia and reduce CV risk. The present narrative review discusses the use of statins and other lipid-lowering drugs such as ezetimibe, fibrates, niacin, anacetrapib and proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors in PAD patients in terms of both CV and limb outcomes...
January 31, 2018: Current Opinion in Pharmacology
https://www.readbyqxmd.com/read/29412431/chemerin-and-factors-related-to-cardiovascular-risk-in-children-and-adolescents-a-systematic-review
#14
Vanessa Sequeira Fontes, Felipe Silva Neves, Ana Paula Carlos Cândido
OBJECTIVE: To review findings on chemerin and factors related to cardiovascular risk in children and adolescents. DATA SOURCE: A systematic review was performed, according to the standards proposed by the PRISMA guideline, on PubMed, Science Direct, and Lilacs databases. The descriptor "chemerin" was used in combination with "children" and "adolescent", no time limit applied. The research encompassed only original articles written in English, conducted with human subjects - the adult and elderly populations excluded -, as well as literature reviews, brief communications, letters, and editorials...
January 15, 2018: Revista Paulista de Pediatria: Orgão Oficial da Sociedade de Pediatria de São Paulo
https://www.readbyqxmd.com/read/29410149/cost-calculation-for-a-flash-glucose-monitoring-system-for-uk-adults-with-type-1-diabetes-mellitus-receiving-intensive-insulin-treatment
#15
Richard Hellmund, Raimund Weitgasser, Deirdre Blissett
AIMS: To estimate the costs associated with a flash glucose monitoring system as a replacement for routine self-monitoring of blood glucose (SMBG) in patients with type 1 diabetes mellitus (T1DM) using intensive insulin, from a UK National Health Service (NHS) perspective. METHODS: The base-case cost calculation was created using the maximum frequency of glucose monitoring recommended by the 2015 National Institute for Health and Care Excellence guidelines (4-10 tests per day)...
February 1, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29407048/personalizing-glucose-lowering-therapy-in-patients-with-type-2-diabetes-and-cardiovascular-disease
#16
REVIEW
Silvio E Inzucchi
Twelve drug categories are marketed in the United States to lower blood glucose concentrations in type 2 diabetes mellitus (T2DM). After metformin, there is disagreement about the optimal next choice for combination therapy. Guidelines advise balancing potency, risks, benefits, and costs. For T2DM and cardiovascular disease (CVD), emerging evidence suggests that certain options may have specific advantages. Specific members of the thiazolidinedione, sodium-glucose cotransporter-2 inhibitor, and glucagon-like peptide-1 receptor agonist classes have been associated with significant reductions in major adverse cardiovascular events, generally in those with established CVD...
March 2018: Endocrinology and Metabolism Clinics of North America
https://www.readbyqxmd.com/read/29406841/slow-titration-and-delayed-intensification-of-basal-insulin-among-patients-with-type-2-diabetes
#17
Michelle Mocarski, Jason Yeaw, Victoria Divino, Mitch DeKoven, German Guerrero, Jakob Langer, Brian Larsen Thorsted
BACKGROUND: Clinical inertia in type 2 diabetes mellitus (T2DM) refers to the failure of clinicians to intensify therapy when indicated. Many T2DM patients remain suboptimally controlled after initiating basal insulin. OBJECTIVE: To examine the prevalence of patients treated with basal insulin but in poor glycemic control (hemoglobin A1c [A1c] ≥ 7%) after initiation and subsequent treatment intensification patterns and glycemic outcomes in a real-world setting...
November 16, 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/29406816/accuracy-and-the-proper-use-of-the-point-of-care-analysis-in-hemoglobin-a1c-measurement
#18
Lei Lynn, Dana Kay, Naji Younes, Sabyasachi Sen, Vivek Jain
BACKGROUND: Diabetes Mellitus is one of the most common chronic diseases in the United States and worldwide. In 2009 the American Diabetes Association (ADA) recommended using A1C greater than 6.5% to diagnose diabetes. Hemoglobin A1C can be measured by laboratory and Point-of-Care (POC) methods. It is important to compare results obtained by the two modalities to determine the proper use of these tests. METHODS: One hundred fifteen patients were identified to have both POC and laboratory A1C values obtained on the same day, between August 2013 and August 2014...
February 6, 2018: Metabolic Syndrome and related Disorders
https://www.readbyqxmd.com/read/29399299/self-management-levels-of-diet-and-metabolic-risk-factors-according-to-disease-duration-in-patients-with-type-2-diabetes
#19
Sukyung Cho, Minkyeong Kim, Kyong Park
BACKGROUND/OBJECTIVES: Metabolic risk factors should be managed effectively in patients with type 2 diabetes mellitus (T2DM) to prevent or delay diabetic complications. This study aimed to compare the self-management levels of diet and metabolic risk factors in patients with T2DM, according to the duration of illness, and to examine the trends in self-management levels during the recent decades. SUBJECTS/METHODS: Data were collected from the Korea National Health and Nutrition Examination Surveys (KNHANES, 1998-2014)...
February 2018: Nutrition Research and Practice
https://www.readbyqxmd.com/read/29396251/glycated-albumin-in-chronic-kidney-disease-pathophysiologic-connections
#20
REVIEW
Alok Raghav, Jamal Ahmad
Nephropathy in diabetes patients is the most common etiology of end-stage kidney disease (ESKD). Strict glycemic control reduces the development and progression of diabetes-related complications, and there is evidence that improved metabolic control improves outcomes in subjects having diabetes mellitus with advanced chronic kidney disease (CKD). Glycemic control in people with kidney disease is complex. Changes in glucose and insulin homoeostasis may occur as a consequence of loss of kidney function and dialysis...
January 30, 2018: Diabetes & Metabolic Syndrome
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