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https://www.readbyqxmd.com/read/29238132/implementing-evidence-based-nutrition-practice-guidelines-for-type-2-diabetes-mellitus-in-lebanon
#1
Najat Yahia, Maya Khoury, Tania Salloum, Rita Younes, Mounzer Saleh, Esther Myers
Lebanon is a Middle Eastern country experiencing a surge in the prevalence of type 2 diabetes mellitus among adults. This pilot study evaluated the feasibility and outcomes of implementing the Academy of Nutrition and Dietetics Evidence-Based Nutrition Practice Guidelines (EBNPGs) as part of medical care for patients newly diagnosed with type 2 diabetes mellitus. Seventy-five patients were recruited from 3 Lebanese hospitals, received nutrition care according to EBNPGs, and were followed up for 12 months. Patients achieved significant improvement in clinical outcomes between baseline and 3, 6, and 12 months...
October 2017: Topics in Clinical Nutrition
https://www.readbyqxmd.com/read/29232162/efficacy-and-safety-of-biosimilar-sar342434-insulin-lispro-in-adults-with-type-2-diabetes-also-using-insulin-glargine-sorella-2-study
#2
Karl-Michael Derwahl, Timothy S Bailey, Karin Wernicke-Panten, Lin Ping, Suzanne Pierre
BACKGROUND: SAR342434 (SAR-Lis) is a biosimilar (follow-on) of insulin lispro (U100; Humalog®; Ly-Lis). This study aimed to show similar efficacy, safety, and immunogenicity of SAR-Lis versus Ly-Lis in adult patients with type 2 diabetes mellitus (T2DM) treated with multiple daily injections, while using insulin glargine (GLA-100; Lantus®) as basal insulin. METHODS: SORELLA 2 was a 6-month, randomized, open-label, Phase 3 study (NCT02294474). Insulin doses were adjusted to achieve fasting and 2-h postprandial glucose targets according to American Diabetes Association guidelines...
December 12, 2017: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/29226100/clinical-food-addiction-is-not-associated-with-development-of-metabolic-complications-in-liver-transplant-recipients
#3
Sammy Saab, Cameron Sikavi, Melissa Jimenez, Matthew Viramontes, Ruby Allen, Youssef Challita, Michelle Mai, Negin Esmailzadeh, Jonathan Grotts, Gina Choi, Francisco Durazo, Mohamed El-Kabany, Steven-Huy Han, Elisa Moreno
Background and Aims: Given the increased risk of post-transplant metabolic syndrome (PTMS; defined by hypertension, diabetes mellitus and hyperlipidemia), we aimed to identify the potential role of food addiction in the development of metabolic complications in the post-liver transplant population. Methods: Inclusion criteria included adult liver transplant recipients followed at our institution between June 2016 and November 2016. Participants were administered a demographic survey as well as the Yale Food Assessment Scale 2...
December 28, 2017: Journal of Clinical and Translational Hepatology
https://www.readbyqxmd.com/read/29224109/testosterone-therapy-and-glucose-homeostasis-in-men-with-testosterone-deficiency-hypogonadism
#4
Farid Saad
Since the early 1990s, it has been recognized that testosterone (T) levels are lower in men with type 2 diabetes mellitus (T2DM) compared with nondiabetic men (controls). Hypogonadism has been reported in approximately 50% of men with T2DM with robust correlations with measures of obesity, such as waist circumference and body mass index (BMI). In longitudinal studies, hypogonadism has been identified as a predictor of incident T2DM. Experimental withdrawal of T led to acute decreased insulin sensitivity, which can be reversed by normalization of T concentrations...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29217675/ten-year-mortality-in-the-wise-study-women-s-ischemia-syndrome-evaluation
#5
Tanya S Kenkre, Pankaj Malhotra, B Delia Johnson, Eileen M Handberg, Diane V Thompson, Oscar C Marroquin, William J Rogers, Carl J Pepine, C Noel Bairey Merz, Sheryl F Kelsey
BACKGROUND: The WISE study (Women's Ischemia Syndrome Evaluation) was a prospective cohort study of 936 clinically stable symptomatic women who underwent coronary angiography to evaluate symptoms and signs of ischemia. Long-term mortality data for such women are limited. METHODS AND RESULTS: Obstructive coronary artery disease (CAD) was defined as ≥50% stenosis on angiography by core laboratory. We conducted a National Death Index search to assess the mortality of women who were alive at their final WISE contact date...
December 2017: Circulation. Cardiovascular Quality and Outcomes
https://www.readbyqxmd.com/read/29216336/managing-diabetic-kidney-disease
#6
Sagen Zac-Varghese, Peter Winocour
Introduction: Diabetes mellitus (DM) is the leading cause of chronic kidney disease (CKD). This review covers the pillars of care essential for the management of diabetic kidney disease (DKD) including (1) early diagnosis, (2) improved glycaemic control, (3) treatment of hypertension, (4) identification and treatment of associated metabolic bone disease and (5) identification and effective management of dyslipidaemia and additional cardiovascular risk factors. Sources of data: We searched PubMed for articles using search terms: diabetic nephropathy, diabetic kidney disease, diabetes and chronic kidney disease...
December 5, 2017: British Medical Bulletin
https://www.readbyqxmd.com/read/29214611/coronary-risk-equivalence-of-diabetes-assessed-by-spect-mpi
#7
Donna Chelle V Morales, Sanjeev P Bhavnani, Alan W Ahlberg, Raja C Pullatt, Deborah M Katten, Donna M Polk, Gary V Heller
BACKGROUND: Several publications and guidelines designate diabetes mellitus (DM) as a coronary artery disease (CAD) risk equivalent. The aim of this investigation was to examine DM cardiac risk equivalence from the perspective of stress SPECT myocardial perfusion imaging (MPI). METHODS AND RESULTS: We examined cardiovascular outcomes (cardiac death or nonfatal MI) of 17,499 patients referred for stress SPECT-MPI. Patients were stratified into four categories: non-DM without CAD, non-DM with CAD, DM without CAD, and DM with CAD, and normal or abnormal perfusion...
December 6, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/29212336/-new-directions-in-bariatric-and-metabolic-surgery
#8
Martin Fried
Czech Republic may be counted among the leading European Countries in regards of the level of delivered high quality multidisciplinary care in treatment of obesity and obesity related metabolic diseases. The 1st Faculty of Medicine (Charles University) and the Faculty General Hospital in Prague played the most important role in the development of bariatric and metabolic surgery in the Czech Republic. pCzech bariatric surgery achieves great successes both on national and international levels. Just to mention some of them: M...
2017: Casopís Lékar̆ů C̆eských
https://www.readbyqxmd.com/read/29211592/quality-of-diabetes-care-for-individuals-with-comorbid-chronic-psychotic-illness-a-sex-based-analysis
#9
Lucy Church Barker, Paul Kurdyak, Binu Jacob, Simone N Vigod
BACKGROUND: Diabetes is common among individuals with chronic psychotic illness, yet they receive lower quality of diabetes care than those without psychosis. Men usually receive higher quality diabetes care than women, but whether this holds true in chronic psychotic illness populations is unknown. We aimed to determine whether quality of diabetes care differs between men and women with chronic psychotic illness. METHODS: This population-based cohort study used Ontario health administrative data to compare women and men with comorbid chronic psychotic illness and diabetes mellitus (2011-2013)...
December 6, 2017: Journal of Women's Health
https://www.readbyqxmd.com/read/29208508/scientific-evidence-on-the-links-between-periodontal-diseases-and-diabetes-consensus-report-and-guidelines-of-the-joint-workshop-on-periodontal-diseases-and-by-the-international-diabetes-federation-and-the-european-federation-of-periodontology
#10
Mariano Sanz, Antonio Ceriello, Martin Buysschaert, Iain Chapple, Ryan T Demmer, Filippo Graziani, David Herrera, Søren Jepsen, Luca Lione, Phoebus Madianos, Manu Mathur, Eduard Montanya, Lior Shapira, Maurizio Tonetti, Daniel Vegh
BACKGROUND: Diabetes and periodontitis are chronic non-communicable diseases independently associated with mortality and have a bidirectional relationship. AIMS: To update the evidence for their epidemiological and mechanistic associations and re-examine the impact of effective periodontal therapy upon metabolic control (glycated haemoglobin, HbA1C). EPIDEMIOLOGY: There is strong evidence that people with periodontitis have elevated risk for dysglycaemia and insulin resistance...
December 2, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29208206/prospective-study-of-nsaids-prescribing-in%C3%A2-saudi-arabia-cardiovascular-and-gastrointestinal-risk-in-patients-with-diabetes%C3%A2-mellitus%C3%A2
#11
Faizan Mazhar, Nafis Haider, Jabeen Sultana, Shahzad Akram, Yousif Ahmed
OBJECTIVES: The purpose of this study was to investigate the patterns of nonsteroidal anti-inflammatory drug (NSAID) prescriptions in diabetes mellitus (DM) patients and to evaluate their suitability based on patient gastrointestinal/cardiovascular (GI/CV) risk profiles. MATERIALS AND METHODS: We retrospectively identified patients with DM, who were seen at a primary care facility from March 1 to 31, 2016. GI risk factors, CV histories, and current medications were recorded...
December 6, 2017: International Journal of Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29207965/long-term-intra-individual-variability-of-albuminuria-in-type-2-diabetes-mellitus-implications-for-categorization-of-albumin-excretion-rate
#12
Amanda Leong, Elif Ilhan Ekinci, Cattram Nguyen, Michele Milne, Mariam Hachem, Matthew Dobson, Richard J MacIsaac, George Jerums
BACKGROUND: Diabetic kidney disease (DKD) is the leading cause of end-stage renal disease in the Western world. Early and accurate identification of DKD offers the best chance of slowing the progression of kidney disease. An important method for evaluating risk of progressive DKD is abnormal albumin excretion rate (AER). Due to the high variability in AER, most guidelines recommend the use of more than or equal to two out of three AER measurements within a 3- to 6-month period to categorise AER...
December 6, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/29206790/aspirin-for-prophylaxis-against-venous-thromboembolism-after-orthopaedic-oncologic-surgery
#13
Gregory M Mendez, Yash M Patel, Daniel A Ricketti, John P Gaughan, Richard D Lackman, Tae Won B Kim
BACKGROUND: Patients who undergo orthopaedic oncologic surgical procedures are at increased risk of developing a venous thromboembolism (VTE). Guidelines from surgical societies are shifting to include aspirin as a postoperative VTE prophylactic agent. The purpose of this study was to review our experience using aspirin as postoperative VTE prophylaxis for orthopaedic oncologic surgical procedures. METHODS: This study was a retrospective review of patients diagnosed with a primary malignant soft-tissue or bone tumor or metastatic carcinoma...
December 6, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/29203507/the-short-term-health-and-economic-burden-of-gestational-diabetes-mellitus-in-china-a-modelling-study
#14
Tingting Xu, Livia Dainelli, Kai Yu, Liangkun Ma, Irma Silva Zolezzi, Patrick Detzel, Hai Fang
OBJECTIVES: Gestational diabetes mellitus (GDM) is associated with a higher risk for adverse health outcomes during pregnancy and delivery for both mothers and babies. This study aims to assess the short-term health and economic burden of GDM in China in 2015. DESIGN: Using TreeAge Pro, an analytical decision model was built to estimate the incremental costs and quality-of-life loss due to GDM, in comparison with pregnancy without GDM from the 28th gestational week until and including childbirth...
December 3, 2017: BMJ Open
https://www.readbyqxmd.com/read/29201367/services-aimed-at-achieving-desirable-clinical-outcomes-in-patients-with-chronic-kidney-disease-and-diabetes-mellitus-a-narrative-review
#15
REVIEW
Fergus William Gardiner, Ezekiel Uba Nwose, Phillip Taderera Bwititi, Judith Crockett, Lexin Wang
There is a large number of patients with chronic kidney disease (CKD), diabetes mellitus (DM), and hypertension (HT) but whether the targets on blood pressure (BP) control in patients with DM and/or CKD are met is not clear. This narrative review therefore investigated evidence on services aimed at achieving desirable clinical results in patients with CKD and DM, and HT in Australia. Literature pertaining to pathology diagnosis and management of these patients as well as the complexities in management were considered...
2017: SAGE Open Medicine
https://www.readbyqxmd.com/read/29200879/cost-consequence-analysis-of-sitagliptin-versus-sulfonylureas-as-add-on-therapy-for-the-treatment-of-diabetic-patients-in-italy
#16
Valentina Lorenzoni, Fabio Baccetti, Stefano Genovese, Enrico Torre, Giuseppe Turchetti
Objective: Diabetes mellitus is a chronic disease related to a significant impact in both epidemiologic and economic terms. In Italy, around 3.6 million people are affected by diabetes and this number is expected to increase significantly in the next few years. As recommended by current national and international guidelines, metformin (Met) is prescribed as first-line pharmacological treatment, and many pharmacological alternatives are available for patients uncontrolled with Met monotherapy...
2017: ClinicoEconomics and Outcomes Research: CEOR
https://www.readbyqxmd.com/read/29197933/impact-of-low-dose-steroids-on-hba1c-levels-and-development-of-pre-diabetes-and-nodat-in-non-diabetic-renal-transplant-recipients-on-long-term-follow-up
#17
F P Tillmann, M Schmitz, L C Rump, I Quack
BACKGROUND: This study aimed to evaluate the impact of 5 mg of prednisolone/day on HbA1c levels and its association with the development of pre-diabetes and new-onset diabetes mellitus (NODAT) in non-diabetic first renal transplant recipients on long-term follow-up. METHODS: Four hundred patients were analysed on an average of 4.1 ± 3.0 years after successful transplantation: 96 (24%) were steroid-free and 304 (76%) treated with 5 mg of prednisolone/day combined with cyclosporine A (CsA) or tacrolimus (Tac) as part of their immunosuppressive protocol...
December 2, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/29197254/utilization-of-lipid-modifying-therapy-and-low-density-lipoprotein-cholesterol-goal-attainment-in-patients-at-high-and-very-high-cardiovascular-risk-real-world-evidence-from-germany
#18
Winfried März, Franz-Werner Dippel, Karlheinz Theobald, Katherine Gorcyca, Şerban R Iorga, David Ansell
BACKGROUND AND AIMS: Elevated low-density lipoprotein cholesterol (LDL-C) is a causal risk factor for cardiovascular (CV) events. European guidelines recommend reducing LDL-C as the primary lipid target to reduce CV risk, using lifestyle modifications and lipid-lowering therapy (LLT). Many European patients do not achieve guideline-recommended LDL-C levels. The present database analysis aimed to assess LLT treatment patterns and LDL-C threshold attainment in Germany in a large, real-world cohort of patients...
November 20, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/29193555/overtreatment-of-older-patients-with-type-2-diabetes-mellitus-in-primary-care
#19
E Hart Huberta, E Rutten Guy, N Bontje Kyra, C Vos Rimke
There are indications of overtreatment in older type 2 diabetes patients in both the US and Europe. We assessed the level of personalized diabetes treatment for older patients in primary care, focusing on overtreatment. Based on Dutch guidelines individuals ≥ 70 years were classified into three HbA1c treatment target groups: 7% (53 mmol/mol), 7.5% (58 mmol/mol) and 8% (64 mmol/mol). In our cohort of 1.002 patients (n=319 ≥ 70 yrs), the 165 patients with target above 7% had more micro- and macrovascular complications, used more often ≥ 5 medicines and were more often frail compared to those with an HbA1c target ≤ 7%...
November 30, 2017: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/29187186/a-mobile-and-web-based-clinical-decision-support-and-monitoring-system-for-diabetes-mellitus-patients-in-primary-care-a-study-protocol-for-a-randomized-controlled-trial
#20
Özge Kart, Vildan Mevsim, Alp Kut, İsmail Yürek, Ayşe Özge Altın, Oğuz Yılmaz
BACKGROUND: Physicians' guideline use rates for diagnosis, treatment and monitoring of diabetes mellitus (DM) is very low. Time constraints, patient overpopulation, and complex guidelines require alternative solutions for real time patient monitoring. Rapidly evolving e-health technology combined with clinical decision support and monitoring systems (CDSMS) provides an effective solution to these problems. The purpose of the study is to develop a user-friendly, comprehensive, fully integrated web and mobile-based Clinical Decision Support and Monitoring System (CDSMS) for the screening, diagnosis, treatment, and monitoring of DM diseases which is used by physicians and patients in primary care and to determine the effectiveness of the system...
November 29, 2017: BMC Medical Informatics and Decision Making
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