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Benign cerebellar astrocytoma

Carmine Antonio Donofrio, Filippo Gagliardi, Marcella Callea, Camillo Ferrari da Passano, Maria Rosa Terreni, Andrea Cavalli, Alfio Spina, Stefania Acerno, Michele Bailo, Samer K Elbabaa, Pietro Mortini
Pilocytic astrocytomas (PAs) are benign glial tumors and one of the most common childhood posterior fossa tumors. Spontaneous intratumoral hemorrhage in PAs occurs occasionally, in about 8-20% of cases. Cerebellar hemorrhages in pediatric population are rare and mainly due to head injuries, rupture of vascular malformations, infections, or hematological diseases. We have investigated the still controversial and unclear pathophysiology underlying intratumoral hemorrhage in PAs. Bleeding in low-grade tumors might be related to structural abnormalities and specific angio-architecture of tumor vessels, such as degenerative mural hyalinization, "glomeruloid" endothelial proliferation, presence of encased micro-aneurysms, and glioma-induced neoangiogenesis...
March 22, 2018: Neurosurgical Review
A N Konovalov, D I Pitskhelauri, A G Melikyan, L V Shishkina, N K Serova, I N Pronin, N M Eliseeva, A M Shkatova, D Ya Samborskiy, A E Bykanov, A L Golovteev, O A Grinenko, D N Kopachev
OBJECTIVE: Despite the advances in microsurgery, the choice of the most adequate approach to the posterior part of the medial temporal region (MTR) remains a very controversial issue. The supracerebellar transtentorial approach (STA) is considered as the most preferable one, since it provides the optimal balance between retraction, incision, and resection of the brain tissue. Here, we present our consecutive series of 20 patients who underwent STA surgery. MATERIAL AND METHODS: Twenty patients with glial tumors affecting the posterior MTR underwent STA surgery between 2006 and 2014...
2015: Zhurnal Voprosy Neĭrokhirurgii Imeni N. N. Burdenko
Tadanori Tomita, Gordan Grahovac
OBJECTIVE: Cerebellopontine angle (CPA) and cerebellomedullary fissure (CMF) tumors are rare in children and information is scarce in the literature. This retrospective study reports their histological distribution and tumor origin, and describes surgical resections and post-operative outcome based upon the authors' consecutive personal series. METHODS: Clinical data of infants and children 16 years old or younger of age treated from 2001 to 2012 by a single surgeon was retrospectively reviewed...
October 2015: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
Charles Raybaud, Vijay Ramaswamy, Michael D Taylor, Suzanne Laughlin
INTRODUCTION: Modern understanding of the relation between the mutated cancer stem cell and its site of origin and of its interaction with the tissue environment is enhancing the importance of developmental anatomy in the diagnostic assessment of posterior fossa tumors in children. The aim of this review is to show how MR imaging can improve on the exact identification of the tumors in the brainstem and in the vicinity of the fourth ventricle in children, using both structural imaging data and a precise topographical assessment guided by the developmental anatomy...
October 2015: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
Hyang-Hwa Ryu, Tae-Young Jung, Gwang-Jun Lee, Kyung-Hwa Lee, Seung-Hoon Jung, Shin Jung, Hee-Jo Baek
PURPOSE: Pilocytic astrocytoma (PA) is a World Health Organization grade I neoplasm that generally follows a benign course. However, in some patients, PA exhibits an aggressive clinical course. Here, we examined the clinical course of pediatric and adult PAs with progression at a single institution. METHODS: Between 1995 and 2013, 39 patients with PA were treated. Nineteen were pediatric patients (mean age, 12 years; range, 1-17 years) with a male-to-female patient ratio of 10:9, while 20 were adults (mean age, 36...
November 2015: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
Ghassan Abuharbid, Majid Esmaeilzadeh, Christian Hartmann, Elvis J Hermann, Joachim K Krauss
PURPOSE: Desmoplastic infantile gliomas (DIG) are rare tumors that occur in infants aged between 1 and 24 months. The tumor in general has a favorable prognosis after surgical resection. There are no treatment algorithms, however, for patients with multiple intracranial and intraspinal presentations. CASE REPORT: In an 11-month-old girl with a history of nystagmus, magnetic resonance imaging (MRI) demonstrated contrast-enhancing lesions in the suprasellar region, the cerebellar vermis, and the spinal axis...
June 2015: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
N Ait Khelifa-Gallois, F Laroussinie, S Puget, C Sainte-Rose, G Dellatolas
UNLABELLED: Abstract Purpose: A number of studies report neurological and cognitive deficits and behavioural disorders in children after surgical treatment for a benign cerebellar tumour. The present study explores functional outcome in adolescents and adults treated for a low-grade cerebellar astrocytoma in childhood. MATERIALS AND METHODS: Participants were 18 adolescents and 46 adults treated for low-grade astrocytoma in childhood. Academic achievement, professional status and neurological, cognitive and behavioural disturbances were collected using self-completed and parental questionnaires for adolescents and phone interview for adults...
2015: Brain Injury: [BI]
N Ait Khelifa-Gallois, S Puget, A Longaud, F Laroussinie, C Soria, C Sainte-Rose, G Dellatolas
It has been suggested that the cerebellum is involved in reading acquisition and in particular in the progression from automatic grapheme-phoneme conversion to the internalization of speech required for silent reading. This idea is in line with clinical and neuroimaging data showing a cerebellar role in subvocal rehearsal for printed verbalizable material and with computational "internal models" of the cerebellum suggesting its role in inner speech (i.e. covert speech without mouthing the words). However, studies examining a possible cerebellar role in the suppression of articulatory movements during silent reading acquisition in children are lacking...
April 2015: Cerebellum
Mohamed A El Beltagy, Mostafa M E Atteya, Alaa El-Haddad, Madiha Awad, Hala Taha, Mohamed Kamal, Sherif Abou El Naga
BACKGROUND: Cerebellar pilomyxoid astrocytomas (PMAs) and intermediate pilomyxoid astrocytomas (IPAs) are collectively called "pilomyxoid-spectrum astrocytomas (PMSAs)." Cerebellar PMSAs are thought to behave more aggressively than pilocytic astrocytomas (PAs). Our objective is to compare PMSAs to PAs in terms of surgical and clinical profiles. METHODS: This retrospective study included 66 cases (35 males and 31 females) with cerebellar astrocytomas treated between July 2007 and December 2012 at Children's Cancer Hospital Egypt (CCHE 57357) with a mean age of 7 (±1...
June 2014: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
Sven O Eicker, Frank W Floeth, Marcel Kamp, Hans-Jakob Steiger, Daniel Hänggi
PURPOSE: 5-Aminolevulinic acid (5-ALA)-based fluorescence-guided surgery was shown to be beneficial for cerebral malignant gliomas. Extension of this technique for resection of meningiomas and cerebral metastasis has been recently evaluated. Aim of the present study is to evaluate the impact of fluorescence-guided surgery in spinal tumor surgery. METHODS: Twenty-six patients with intradural spinal tumors were included in the study. 5-ALA was administered orally prior to the induction of anesthesia...
June 2013: European Spine Journal
Yee Hui Yeo, Nicholas P Byrne, George J Counelis, Arie Perry
Pilocytic astrocytoma (PA) is the most common pediatric tumor, with the vast majority being benign (WHO Grade I). Herein, we present a rare sporadic (not radiation- or NF1-associated) anaplastic PA arising from the cerebellum of an adult patient. The diagnosis was based on the coexistence of classic PA and more cellular foci, associated with both tumor necrosis and up to 27 mitoses per 10 high power fields. Based on these features, the tumor was felt to be equivalent in biological behavior to that of a WHO Grade III astrocytoma...
May 2013: Clinical Neuropathology
Jesús Vaquero, Cristobal Saldaña, Santiago Coca, Mercedes Zurita
Dysembryoplastic neuroepithelial tumor (DNT) is a benign neoplasm with typical supratentorial location, but the possibility of these rare tumors can also be located in the posterior fossa must be taken into account. We report a 21-year-old woman that suffered gait instability, headache, and diplopia. On CT-scan, an intraparenchymatous cerebellar tumor was disclosed. It was isodense, showing light enhancement after contrast administration. On MRI (T1-weighted image) the tumor was isointense, showing inhomogeneous hyperintensity after-gadolinium administration...
2012: Case Reports in Pathology
Mohamed Ali El-Gaidi
OBJECTIVE: The characteristics of 451 Egyptian children (aged 0-14 years) with primary intracranial neoplasms were investigated for demographic, clinical, topographical and pathological features using the most recent 2007 Classification of Central Nervous System Tumors. PATIENTS AND METHODS: This was a retrospective study performed in the Departments of Pediatric Neurosurgery of the Cairo University Hospitals from 2005 to 2008. RESULTS: There was a slight male predominance (51...
2011: Pediatric Neurosurgery
Clare Samuelson, Kate M Forman, Stuart Smith
We present the case of an 8-year-old girl with chronic idiopathic thrombocytopenic purpura (ITP) and a short history suggestive of raised intracranial pressure. Urgent computed tomography scan of the head showed a large bleed into a left cerebellar lesion. She underwent treatment with intravenous immunoglobulin (IVIg) and steroids to increase her platelet count, followed by excision of the lesion, which was found to be a benign pilocytic astrocytoma. The patient made a complete recovery and shortly afterwards underwent splenectomy, following which there was complete resolution of her thrombocytopenia...
2010: BMJ Case Reports
Min-Su Kim, Sang Woo Kim, Chul-Hoon Chang, Oh-Lyong Kim
Cerebellar pilocytic astrocytomas (PAs) are benign gliomas predominantly found in the pediatric population. Intracranial hemorrhages are extremely rare in initial presentations of cerebellar PAs. There are no reports in the medical literature of adult cerebellar PA cases presenting with intratumoral hemorrhage. We report 2 cases of adult cerebellar pilocytic astrocytomas with intratumoral hemorrhage. The first case is a 37-year-old woman presenting with severe headache, nausea, and vomitting. Computed tomography demonstrated an acute hemorrhage adjacent to the right cerebellar hemisphere and hydrocephalus...
June 2011: Journal of Korean Neurosurgical Society
Hideki Ogiwara, Robin M Bowman, Tadanori Tomita
BACKGROUND: The long-term prognosis of cerebellar astrocytomas needs to be reviewed. OBJECTIVE: To elucidate the factors influencing tumor recurrence or progression and to determine how long these patient with cerebellar astrocytomas require surveillance with neuroimaging. METHODS: A retrospective review of 101 children surgically treated for a cerebellar astrocytoma and followed up for > 10 years was performed. RESULTS: Mean follow-up was 18...
January 2012: Neurosurgery
Rakesh Redhu, Trimurti D Nadkarni
A 26-year-old male presented with a rare cerebellar pilocytic astrocytoma with multicompartmental subarachnoid metastases. Cerebrospinal fluid dissemination of low grade astrocytoma at presentation is rare in adults. In the present patient, clinical and neuroradiological follow-up at 4 years, without adjuvant treatment, revealed non progression of tumors. The occurrence of benign dormancy, low grade tumor histology and multifocal involvement of the neuraxis is rare. Close clinical observation is the best approach for management of such a patient...
October 2011: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
Yuuta Kamoshima, Yutaka Sawamura, Nobuharu Saitoh, Masahito Kawabori, Kiyohiro Houkin, Kanako Kubota
A 1-year-old female infant presented with congenital giant, hairy and pigmented nevi. MRI scan as screening test revealed a cerebellar tumor. A diagnosis of provisional neurocutaneous melanosis was made on the basis of the patient's MRI and physical findings. At her 6 years of age, MRI revealed the tumor grown up to 3 cm diameter in 5 years. The cerebellar tumor was removed partially using the occipital transtentorial approach for tissue diagnosis. The color of the cerebellar tumor was whitish and contained neither benign nor malignant melanocyte...
May 2011: No Shinkei Geka. Neurological Surgery
Fuminari Komatsu, Hiroshi Kawaguchi, Hitoshi Tsugu, Shinya Oshiro, Mika Komatsu, Takeo Fukushima, Kazuki Nabeshima, Tooru Inoue
A 23-year-old man was admitted with a rare case of radiation-induced astrocytoma manifesting as 3-month history of unstable gait. He had received 50 Gy of irradiation therapy for a germ cell tumor in the right basal ganglia 13 years earlier. Magnetic resonance (MR) imaging on admission showed a non-enhanced mass lesion in the right cerebellar hemisphere with expansion to the vermis. The histological diagnosis of the stereotaxic biopsy specimen was grade II astrocytoma. Two months later, he developed drowsiness, and MR imaging demonstrated that the tumor had enlarged and was enhanced after gadolinium injection...
2011: Neurologia Medico-chirurgica
Ichiyo Shibahara, Tomohiro Kawaguchi, Masayuki Kanamori, Shingo Yonezawa, Hiroki Takazawa, Kenichiro Asano, Hiroki Ohkuma, Mitsuomi Kaimori, Tatsuya Sasaki, Michiharu Nishijima
Pilocytic astrocytoma sometimes transforms to a malignant type, and previous radiation therapy is considered to be a key factor. We report a case of pilocytic astrocytoma with histological malignant features without previous radiation therapy. A 21-year-old man presented a sudden onset of severe headache. Neuroimaging had detected a cystic mass in the posterior fossa at the age of one year without therapeutic intervention. On admission, computed tomography depicted a brain tumor in the posterior fossa with cystic components, intratumoral hemorrhage, and upward herniation...
2011: Neurologia Medico-chirurgica
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