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https://www.readbyqxmd.com/read/27891390/effectiveness-of-centchroman-on-regression-of-fibroadenosis-and-mastalgia
#1
Udayakumar Rajswaroob, Rajendiran Kannan, Narayanasamy Subbaraju Kannan, T Tirouaroul
INTRODUCTION: Fibroadenosis and mastalgia are common among the women in reproductive age group. Treatment for these conditions is not yet standardised. Most of the drugs used for fibroadenosis and mastalgia are expensive and have side effects. AIM: To find out the efficacy of centchroman, a Selective Estrogens Receptor Modulator (SERM) on regression of fibroadenosis and mastalgia. MATERIALS AND METHODS: Fifty one patients with mastalgia/fibroadenosis were treated with centchroman 30mg once daily on alternate days for a period of 3 months and followed up weekly for six months with Mastalgia chart and Visual Analog Scale (VAS) pain score...
October 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27857920/effectiveness-of-osteoporosis-drug-in-postmenopausal-women-with-spinal-compression-fracture-combined-consecutive-therapy-of-teriparatide-and-raloxifene-versus-bisphosphonate-single
#2
Chang Jin Shin, Sion Kim, Chun Sik Choi, Hyun Chul Shin, Young Joon Kwon
OBJECTIVE: Bisphosphonate, a typical bone resorption inhibitor, is an important first-line drug for treating osteoporosis. Recent studies show a novel paradigm in stimulating bone formation. Teriparatide, which is composed of recombinant human parathyroid hormone, stimulates osteoblasts and induces bone regeneration. Bone mineral density (BMD) that was used before and after the treatment with anti-osteoporosis drug was compared for the effectiveness in therapy between a combination of teriparatide and selective estrogen receptor modulator (SERM), and bisphosphonate...
October 2016: Korean Journal of Neurotrauma
https://www.readbyqxmd.com/read/27855957/age-and-duration-of-testosterone-therapy-predict-time-to-return-of-sperm-count-after-human-chorionic-gonadotropin-therapy
#3
Taylor P Kohn, Matthew R Louis, Stephen M Pickett, Mark C Lindgren, Jaden R Kohn, Alexander W Pastuszak, Larry I Lipshultz
OBJECTIVE: To determine factors that influence sperm recovery after T-associated infertility. DESIGN: Clinical retrospective study. SETTING: Academic male-infertility urology clinic. PATIENT(S): Sixty-six men who presented with infertility after T use. INTERVENTION(S): T cessation and combination high-dose hCG and selective estrogen modulator (SERM) therapy. MAIN OUTCOME MEASURE(S): Whether patients successfully achieved or failed to achieve a total motile count (TMC) of greater than 5 million sperm within 12 months of T cessation and initiation of therapy...
November 14, 2016: Fertility and Sterility
https://www.readbyqxmd.com/read/27848000/effects-of-post-fire-plant-cover-in-the-performance-of-two-cordilleran-cypress-austrocedrus-chilensis-seedling-stocktypes-planted-in-burned-forests-of-northeastern-patagonia-argentina
#4
María F Urretavizcaya, Héctor E Gonda, Guillermo E Defossé
Cordilleran cypress (Austrocedrus chilensis [D.Don] Pic. Serm. et Bizarri) forests occupy 140,000 ha along a sharp environmental gradient of central Andean-Patagonia in Argentina. Every summer, about 3200 ha of these forests are affected by wildfires, taking thereafter long time to recover. To accelerate forest recovery, we determined in xeric and mesic cypress stands burned 5 and 2 year before whether survival and growth of two planted cypress seedling stocktypes are affected by plant cover and contrasting precipitation conditions...
November 15, 2016: Environmental Management
https://www.readbyqxmd.com/read/27817194/suppression-of-isoproterenol-induced-apoptosis-in-h9c2-cardiomyoblast-cells-by-daidzein-through-activation-of-akt
#5
Wei-Syun Hu, Yueh-Min Lin, Wei-Wen Kuo, Lung-Fa Pan, Yu-Lan Yeh, Yi-Hui Li, Chia-Hua Kuo, Ray-Jade Chen, V. Vijaya Padma, Tung-Sheng Chen, Chih-Yang Huang
Increased serum norepinephrine level is one of pathological processes relating to heart disease. Estrogens are considered as potential therapeutics for the treatment of heart disease; however, estrogen supplementation shows some side-effects, such as increasing the risk of developing breast, endometrial and ovarian cancers. This study investigated the cardio-protective effects of daidzein (Dai), a selective estrogen receptor modulator (SERM) from soy bean extract, in H9c2 cardiomyoblast cells treated with isoproterenol (ISO), a norepinephrine analog...
December 31, 2016: Chinese Journal of Physiology
https://www.readbyqxmd.com/read/27802325/selective-estrogen-receptor-modulators-suppress-hif1%C3%AE-protein-accumulation-in-mouse-osteoclasts
#6
Mayu Morita, Yuiko Sato, Ryotaro Iwasaki, Tami Kobayashi, Ryuichi Watanabe, Takatsugu Oike, Kana Miyamoto, Yoshiaki Toyama, Morio Matsumoto, Masaya Nakamura, Hiromasa Kawana, Taneaki Nakagawa, Takeshi Miyamoto
Anti-bone resorptive drugs such as bisphosphonates, the anti-RANKL antibody (denosumab), or selective estrogen receptor modulators (SERMs) have been developed to treat osteoporosis. Mechanisms underlying activity of bisphosphonates or denosumab in this context are understood, while it is less clear how SERMs like tamoxifen, raloxifene, or bazedoxifene inhibit bone resorption. Recently, accumulation of hypoxia inducible factor 1 alpha (Hif1α) in osteoclasts was shown to be suppressed by estrogen in normal cells...
2016: PloS One
https://www.readbyqxmd.com/read/27793668/zip-restores-estrogen-receptor-expression-and-response-to-tamoxifen-in-estrogen-receptor-negative-tumors
#7
Ning Zhu, Jing Zhang, Xiaodong Qin, Ruidong Miao, Yuping Du, Jinbo Yang
As a component of NURD histone deacetylase complex, ZIP serves as a tumor suppressor gene in the development of breast tumors. However, whether it takes part in chemotherapy resistance remains poorly defined. In the present study, we reported that ZIP enhanced the response to SERM chemotherapy in ER-negative cells. Overexpression of ZIP suppressed EGFR expression level and restored ERalpha protein level in cells resistant to Tamoxifen. In vivo data confirmed those in vitro findings.
October 25, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27777390/-pharmacokinetics-of-selective-estrogen-receptor-modulators-serms
#8
Masakazu Terauchi
Selective estrogen receptor modulators(SERMs), or estrogen receptor agonists/antagonists(ERAAs), are a class of compounds that function as estrogen receptor(ER)agonists or antagonists tissue-dependently. Two types of SERMs are currently used in Japan to treat osteoporosis, raloxifene(RLX:Evista)and bazedoxifene(BZA:Viviant). This article describes the pharmacokinetics of these two drugs.
2016: Clinical Calcium
https://www.readbyqxmd.com/read/27735020/ospemifene-a-safe-treatment-of-vaginal-atrophy
#9
L Del Pup
OBJECTIVE: Vaginal atrophy is a chronic, progressive medical condition that affects fifty percent of postmenopausal women, causing symptoms like dyspareunia, vaginal dryness, and vaginal irritation. Until recently, the only prescription options were systemic and vaginal estrogen therapies that might be limited by concerns about long-term safety and breast cancer risk. The objective is to analyze the literature about ospemifene, a tissue-selective estrogen receptor modulator (SERM) recently approved for the treatment of vulvovaginal atrophy and dyspareunia and to compare its effects with those of the other SERMs to assess its safety...
September 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27734024/a-4-year-old-boy-with-shortness-of-breath
#10
Sermed Mezher, Mariam Rahm, Sunanda Sudarsanan, Surendran Chandrasekaran
No abstract text is available yet for this article.
2016: Global Pediatric Health
https://www.readbyqxmd.com/read/27729460/antiestrogens-structure-activity-relationships-and-use-in-breast-cancer-treatment
#11
Tatiana Traboulsi, Mohamed El Ezzy, James Gleason, Sylvie Mader
About 70% of breast tumors express estrogen receptor alpha (ERα), which mediates the proliferative effects of estrogens on breast epithelial cells, and are candidates for treatment with antiestrogens, steroidal or non-steroidal molecules designed to compete with estrogens and antagonize ERs. The variable patterns of activity of antiestrogens (AEs) in estrogen target tissues and the lack of systematic cross-resistance between different types of molecules have provided evidence for different mechanisms of action...
October 11, 2016: Journal of Molecular Endocrinology
https://www.readbyqxmd.com/read/27729078/chalepin-isolated-from-ruta-angustifolia-l-pers-induces-mitochondrial-mediated-apoptosis-in-lung-carcinoma-cells
#12
Jaime Stella Moses Richardson, Gautam Sethi, Guan Serm Lee, Sri Nurestri Abdul Malek
BACKGROUND: Cancer has been one of the leading causes of mortality in this era. Ruta angustifolia L. Pers has been traditionally used as an abortifacient, antihelmintic, emmenagogue and ophthalmic. In Malaysia and Singapore, the local Chinese community used it for the treatment of cancer. METHODS: In this study, the methanol and fractionated extracts (hexane, chloroform, ethyl acetate and water) of R. angustifolia were tested for its cytotoxicity using the sulforhodamide (SRB) cytotoxicity assay against HCT-116, A549, Ca Ski and MRC5 cell lines...
October 12, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27696078/quality-of-life-qol-and-symptom-burden-sb-in-patients-with-breast-cancer
#13
Julia Hamer, Rachel McDonald, Liying Zhang, Sunil Verma, Angela Leahey, Christine Ecclestone, Gillian Bedard, Natalie Pulenzas, Anchal Bhatia, Ronald Chow, Carlo DeAngelis, Janet Ellis, Eileen Rakovitch, Justin Lee, Edward Chow
PURPOSE: The purpose of this study was to determine the quality of life (QOL) and symptom burden (SB) among breast cancer patients. METHODS: Patients with DCIS, early stage, locally advanced, or metastatic breast cancer completed the Edmonton Symptom Assessment System (ESAS) and the Functional Assessment of Cancer Therapy for Breast Cancer (FACT-B). Patients were divided into subsequent cohorts based on their last day of treatment, age at enrollment, radiation, chemotherapy, and hormone therapy...
September 30, 2016: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/27663804/the-role-of-selective-estrogen-receptor-modulators-in-the-treatment-of-schizophrenia
#14
Agnieszka Bratek, Krzysztof Krysta, Karolina Drzyzga, Justyna Barańska, Krzysztof Kucia
BACKGROUND: Gender differences in schizophrenia have been recognized for a long time and it has been widely accepted that sex steroid hormones, especially estradiol, are strongly attributed to this fact. Two hypotheses regarding estradiol action in psychoses gained special research attention - the estrogen protection hypothesis and hypoestrogenism hypothesis. A growing number of studies have shown benefits in augmenting antipsychotic treatment with estrogens or selective estrogen receptor modulators (SERM)...
September 2016: Psychiatria Danubina
https://www.readbyqxmd.com/read/27647770/efficacy-of-ormeloxifene-versus-oral-contraceptive-in-the-management-of-abnormal-uterine-bleeding-due-to-uterine-leiomyoma
#15
Alka Kriplani, Astha Srivastava, Vidushi Kulshrestha, Garima Kachhawa, Nutan Agarwal, Neerja Bhatla, Smriti Hari
AIM: To compare ormeloxifene with combined oral contraceptive (COC) in abnormal uterine bleeding (AUB) due to leiomyoma (AUB-L). METHODS: Fifty women with AUB-L were randomized after informed consent and institute ethics clearance. Group I (n = 25) was given ormeloxifene (a SERM i.e. selective estrogen receptor modulator) 60 mg twice per week and group II (n = 25) was given COC (ethinyl estradiol 30 μg with desogestrel 150 μg) on days 1-21 for 6 months...
September 20, 2016: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/27647367/a-new-suzuki-synthesis-of-triphenylethylenes-that-inhibit-aromatase-and-bind-to-estrogen-receptors-%C3%AE-and-%C3%AE
#16
Li-Ming Zhao, Hai-Shan Jin, Jinzhong Liu, Todd C Skaar, Joseph Ipe, Wei Lv, David A Flockhart, Mark Cushman
The design and synthesis of dual aromatase inhibitors/selective estrogen receptor modulators (AI/SERMs) is an attractive strategy for the discovery of new breast cancer therapeutic agents. Previous efforts led to the preparation of norendoxifen (4) derivatives with dual aromatase inhibitory activity and estrogen receptor binding activity. In the present study, some of the structural features of the potent AI letrozole were incorporated into the lead compound (norendoxifen) to afford a series of new dual AI/SERM agents based on a symmetrical diphenylmethylene substructure that eliminates the problem of E,Z isomerization encountered with norendoxifen-based AI/SERMs...
November 1, 2016: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/27644075/neuroprotective-and-immunomodulatory-effects-of-raloxifene-in-the-myenteric-plexus-of-a-mouse-model-of-parkinson-s-disease
#17
Andrée-Anne Poirier, Mélissa Côté, Mélanie Bourque, Marc Morissette, Thérèse Di Paolo, Denis Soulet
Motor symptoms in Parkinson's disease (PD) are often preceded by nonmotor symptoms related to dysfunctions of the autonomic nervous system such as constipation, defecatory problems, and delayed gastric emptying. These gastrointestinal impairments are associated with the alteration of dopaminergic (DAergic) neurons in the myenteric plexus of the gut. Recently, we demonstrated the anti-inflammatory properties of estrogens to treat intestinal neurodegeneration in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of PD...
August 16, 2016: Neurobiology of Aging
https://www.readbyqxmd.com/read/27632930/laparoscopic-management-of-huge-myoma-nascendi
#18
Nuri Peker, Savas Gundogan, Fatih Sendag
To present the feasibility of laparoscopic management of huge myoma nascendi DESIGN: Step by step explanation of the surgery using video SETTING: Uterine fibroids are the most common benign neoplasm of the female reproductive tract with the estimated incidence of 25-30% at reproductive age. Patients generally have no symptoms however patients those have symptoms such as severe pelvic pain, heavy uterine bleeding or infertility may undergo surgery. The traditional management is surgery however uterine artery embolization, hormonal therapy using GnRH (Gonadotropin-Releasing Hormone) agonists or SERM (Selective Estrogen Receptor Modulator) should be preferred as the medical approach...
September 12, 2016: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/27632929/laparoscopic-management-of-huge-cervical-myoma
#19
Nuri Peker, Savaş Gundogan, Fatih Şendağ
To present the feasibility of laparoscopic management of huge cervical myoma DESIGN: Step by step explanation of the surgery using video SETTING: Uterine fibroids are the most common benign neoplasm of the female reproductive tract with the estimated incidence of 25-30% at reproductive age. Patients generally have no symptoms however patients those have symptoms such as severe pelvic pain, heavy uterine bleeding or infertility may undergo surgery. The traditional management is surgery however uterine artery embolization, hormonal therapy using GnRH (Gonadotropin-Releasing Hormone) agonists or SERM (Selective Estrogen Receptor Modulator) should be preferred as the medical approach...
September 12, 2016: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/27617055/physician-and-patient-barriers-to-breast-cancer-preventive-therapy
#20
Susan Hum, Melinda Wu, Sandhya Pruthi, Ruth Heisey
The uptake of selective estrogen receptor modulators (SERMs) and aromatase inhibitors (AIs) for the primary prevention of breast cancer is low, despite their proven efficacy in several randomized clinical trials. This review summarizes the latest data on physicians' and women's barriers to breast cancer preventive therapy. Physicians' challenges include: identifying suitable candidates for preventive therapy, inadequate training and confidence in risk assessment and counselling, insufficient knowledge of risk-reducing medications, and lack of time...
2016: Current Breast Cancer Reports
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