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https://www.readbyqxmd.com/read/28337359/effect-of-acupuncture-on-postoperative-ileus-after-distal-gastrectomy-for-gastric-cancer
#1
Se Yun Jung, Hyun Dong Chae, Ung Rae Kang, Min Ah Kwak, In Hwan Kim
PURPOSE: Acupuncture has recently been accepted as a treatment option for managing postoperative ileus (POI) and various functional gastrointestinal disorders. Therefore, we conducted a prospective randomized study to evaluate the effect of acupuncture on POI and other surgical outcomes in patients who underwent gastric surgery. MATERIALS AND METHODS: Thirty-six patients who underwent distal gastrectomy for gastric cancer from March to December 2015 were randomly assigned to acupuncture or non-acupuncture (NA) groups at 1:1 ratio...
March 2017: Journal of Gastric Cancer
https://www.readbyqxmd.com/read/28331195/galactose-and-its-metabolites-deteriorate-metaphase-ii-mouse-oocyte-quality-and-subsequent-embryo-development-by-disrupting-the-spindle-structure
#2
Mili Thakur, Faten Shaeib, Sana N Khan, Hamid-Reza Kohan-Ghadr, Roohi Jeelani, Sarah R Aldhaheri, Bernard Gonik, Husam M Abu-Soud
Premature ovarian insufficiency (POI) is a frequent long-term complication of classic galactosemia. The majority of women with this disorder develop POI, however rare spontaneous pregnancies have been reported. Here, we evaluate the effect of D-galactose and its metabolites, galactitol and galactose 1-phosphate, on oocyte quality as well as embryo development to elucidate the mechanism through which these compounds mediate oocyte deterioration. Metaphase II mouse oocytes (n = 240), with and without cumulus cells (CCs), were exposed for 4 hours to D-galactose (2 μM), galactitol (11 μM) and galactose 1-phosphate (0...
March 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28319904/sensitivity-enhancement-of-graphene-zinc-oxide-nanocomposite-based-electrochemical-impedance-genosensor-for-single-stranded-rna-detection
#3
Sze Shin Low, Hwei-San Loh, Jian Sheng Boey, Poi Sim Khiew, Wee Siong Chiu, Michelle T T Tan
An efficient electrochemical impedance genosensing platform has been constructed based on graphene/zinc oxide nanocomposite produced via a facile and green approach. Highly pristine graphene was synthesised from graphite through liquid phase sonication and then mixed with zinc acetate hexahydrate for the synthesis of graphene/zinc oxide nanocomposite by solvothermal growth. The as-synthesised graphene/zinc oxide nanocomposite was characterised with scanning electron microscopy (SEM), transmission electron microscopy (TEM), Raman spectroscopy and X-ray diffractometry (XRD) to evaluate its morphology, crystallinity, composition and purity...
February 27, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28306340/a-potential-functional-association-between-mutant-bmpr2-and-primary-ovarian-insufficiency
#4
Liliana Catherine Patiño, Daniel Silgado, Paul Laissue
Primary ovarian insufficiency (POI) affects ~1% of women in the general population. Despite numerous attempts at identifying POI genetic aetiology, coding mutations in only a few genes have been functionally related to POI pathogenesis. It has been suggested that mutant BMPR2 might contribute towards the phenotype. Several BMP15 (a BMPR2 ligand) coding mutations in human species have been related to POI pathogenesis. The BMPR2 p.Ser987Phe mutation, previously identified in a woman with POI, might therefore lead to cellular dysfunction contributing to the phenotype...
March 17, 2017: Systems Biology in Reproductive Medicine
https://www.readbyqxmd.com/read/28303409/cardiovascular-inflammation-is-reduced-with-methotrexate-in-diabetes
#5
Adrian Quan, Yi Pan, Krishna K Singh, John Polemidiotis, Hwee Teoh, Howard Leong-Poi, Subodh Verma
Diabetes increases the risk of vascular events and mortality. While earlier type 2 diabetes trials demonstrated that intensive glucose lowering reduces microvascular complications, it is only recently that treatment with some of the newer antihyperglycemic agents has been associated with macrovascular benefits. We report herein that db/db mice concomitantly fed the Western diet and treated with the anti-inflammatory agent methotrexate display a less aggressive inflammatory (lower serum IL-1β, IL-6, SDF-1, and TNFα levels; higher circulating adiponectin, IL-12p70 and IL-10 concentrations; lower aortic VCAM-1 levels) profile than their saline-treated counterpart...
March 16, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28301062/metabolomic-guided-discovery-of-alzheimer-s-disease-biomarkers-from-body-fluid
#6
REVIEW
Che Nor Adlia Enche Ady, Siong Meng Lim, Lay Kek Teh, Mohd Zaki Salleh, Ai-Vyrn Chin, Maw Pin Tan, Philip Jun Hua Poi, Shahrul Bahyah Kamaruzzaman, Abu Bakar Abdul Majeed, Kalavathy Ramasamy
The rapid increase in the older population has made age-related diseases like Alzheimer's disease (AD) a global concern. Given that there is still no cure for this neurodegenerative disease, the drastic growth in the number of susceptible individuals represents a major emerging threat to public health. The poor understanding of the mechanisms underlying AD is deemed the greatest stumbling block against progress in definitive diagnosis and management of this disease. There is a dire need for biomarkers that can facilitate early diagnosis, classification, prognosis, and treatment response...
March 16, 2017: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/28298208/looking-back-to-move-forward-a-twenty-year-audit-of-herpes-zoster-in-asia-pacific
#7
REVIEW
Liang-Kung Chen, Hidenori Arai, Liang-Yu Chen, Ming-Yueh Chou, Samsuridjal Djauzi, Birong Dong, Taro Kojima, Ki Tae Kwon, Hoe Nam Leong, Edward M F Leung, Chih-Kuang Liang, Xiaohong Liu, Dilip Mathai, Jiun Yit Pan, Li-Ning Peng, Eduardo Rommel S Poblete, Philip J H Poi, Stewart Reid, Terapong Tantawichien, Chang Won Won
BACKGROUND: Herpes zoster (HZ) is a prevalent viral disease that inflicts substantial morbidity and associated healthcare and socioeconomic burdens. Current treatments are not fully effective, especially among the most vulnerable patients. Although widely recommended, vaccination against HZ is not routine; barriers in Asia-Pacific include long-standing neglect of adult immunisation and sparse local data. To address knowledge gaps, raise awareness, and disseminate best practice, we reviewed recent data and guidelines on HZ from the Asia-Pacific region...
March 15, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28289071/disorganization-of-the-germ-cell-pool-leads-to-primary-ovarian-insufficiency
#8
Ikko Kawashima, Kazuhiro Kawamura
The mammalian ovary is an organ that controls female germ cell development, storing them and releasing mature oocytes for transporting to the oviduct. During the fetal stage, female germ cells change from a proliferative state to meiosis before forming follicles with the potential for growth of surrounding somatic cells. Understanding of molecular and physiological bases of germ cell development in the fetal ovary contributed not only to the elucidation of genetic disorders in primary ovarian insufficiency (POI), but also advancement of novel treatments for patients with POI...
March 13, 2017: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/28285365/postoperative-ileus-in-an-enhanced-recovery-pathway-a-retrospective-cohort-study
#9
Fabian Grass, Juliette Slieker, Jonas Jurt, Anne Kummer, Josep Solà, Dieter Hahnloser, Nicolas Demartines, Martin Hübner
PURPOSE: Enhanced recovery after surgery (ERAS) protocols advocate no nasogastric tubes after colorectal surgery, but postoperative ileus (POI) remains a challenging clinical reality. The aim of this study was to assess incidence and risk factors of POI. METHODS: This retrospective analysis included all consecutive colorectal surgical procedures since May 2011 until November 2014. Uni- and multivariate risk factors for POI were identified by multiple logistic regression and functional and surgical outcomes assessed...
March 11, 2017: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/28283741/proposal-of-a-new-classification-of-postoperative-ileus-based-on-its-clinical-impact-results-of-a-global-survey-and-preliminary-evaluation-in-colorectal-surgery
#10
Aurélien Venara, Karem Slim, Jean-Marc Regimbeau, Pablo Ortega-Deballon, Bruno Vielle, Emilie Lermite, Guillaume Meurette, Antoine Hamy
PURPOSE: There is no consensual definition of postoperative ileus (POI), which leads to a lack of reproducibility. The aims of this study were (i) to propose and evaluate a classification of postoperative ileus based on its consequences and (ii) to assess the reproducibility of the classification. METHODS: A national global survey was carried out according to the DELPHI method in order to create a classification of primary POI. The classification was subsequently tested on a cohort of patients who underwent colorectal surgery...
March 10, 2017: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/28282802/in-situ-memory-t-cells-and-patterns-of-invasion-predict-outcome-in-patients-with-early-stage-oral-squamous-cell-carcinoma
#11
Shan Wang, Jiankai Xu, Yan Meng, Dongxia Qiang, Changsheng Sun, Lei Shi, Eryang Zhao
PURPOSE: The objective of this study was to explore the prognostic value of in situ memory T cells and patterns of invasion (POI) in early stage oral squamous cell carcinoma (OSCC). METHODS: One hundred fifty-seven patients with early stage (cT1T2N0) OSCC were identified from a pre-existing database of patients with oral cancer and were classified by POI according to hematoxylin-eosin staining. We examined the impact of the immunohistochemical expression of CD45RO in OSCC...
March 3, 2017: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/28278532/genetics-of-reproductive-aging-from-gonadal-dysgenesis-through-menopause
#12
Swapna Desai, Aleksandar Rajkovic
Reproduction is essential for the survival of the species and is influenced by external factors such as smoking and exposure to chemotherapy as well as chronic disorders such as obesity and autoimmunity. Reproductive senescence, such as menopause, is also dependent on multiple intrinsic genetic factors. Reproductive aging is not isolated from an overall aging process, and several studies strongly support the link between the early age of menopause and mortality. The extreme form of reproductive aging is primary ovarian insufficiency (POI) with prevalence ranging from 1 to 5% of the female population...
March 2017: Seminars in Reproductive Medicine
https://www.readbyqxmd.com/read/28277883/prucalopride-for-the-treatment-of-ileus
#13
Christopher J Smart, Kamran I Malik
Postoperative ileus (POI) is an impairment of coordinated gastrointestinal (GI) motility that develops as a consequence of abdominal surgery and is a major factor contributing to patient morbidity and prolonged hospitalisation. Despite the availability of various options its treatment is still under debate. This review will focus on effect of Prucalopride (5-HT4 receptor agonist) on postoperative ileus based on the existing literature. Areas covered: A literature search of MEDLINE, EMBASE and COCHRANE Library was performed concerning topics related to the treatment of ileus with prucalopride...
March 10, 2017: Expert Opinion on Investigational Drugs
https://www.readbyqxmd.com/read/28277140/interactive-case-based-learning-improves-resident-knowledge-and-confidence-in-reproductive-endocrinology-and-infertility
#14
Kara N Goldman, Ashley W Tiegs, Kristen Uquillas, Margaret Nachtigall, M Elizabeth Fino, Abigail F Winkel, Veronica Lerner
Resident physicians' scores on the REI section of the CREOG exam are traditionally low, and nearly 40% of house staff nation-wide perceive their REI knowledge to be poor. We aimed to assess whether an interactive case-based group-learning curriculum would narrow the REI knowledge gap by improving understanding and retention of core REI concepts under the time constraints affecting residents. A three-hour case-based workshop was developed to address four primary CREOG objectives. A multiple-choice test was administered immediately before and after the intervention and 7 weeks post-workshop, to evaluate both knowledge and confidence...
February 21, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28277119/brain-derived-neurotrophic-factor-bdnf-plasma-concentration-in-patients-diagnosed-with-premature-ovarian-insufficiency-poi
#15
Adam Czyzyk, Dorota Filipowicz, Agnieszka Podfigurna, Paula Ptas, Malgorzata Piestrzynska, Roman Smolarczyk, Andrea R Genazzani, Blazej Meczekalski
Premature ovarian insufficiency (POI) is defined as a cessation of function of ovaries in women younger than 40 years old. Brain-derived neurotrophic factor (BDNF) is a protein critically involved in neuronal growth and metabolism. BDNF also has been shown to be important regulator of oocyte maturation. Recent data show that BDNF can be potentially involved in POI pathology. The aim of the study was to assess the BDNF plasma concentrations in patients diagnosed with idiopathic POI. 23 women diagnosed with POI (age 31 ± 7 years) and 18 (age 31 ± 3) controls were included to the study, matched according to age and body mass index...
February 28, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28270022/a-phase-1-trial-of-the-hdac-inhibitor-ar-42-in-patients-with-multiple-myeloma-and-t-and-b-cell-lymphomas
#16
Douglas W Sborov, Alessandro Canella, Erinn M Hade, Xiaokui Mo, Soun Khountham, Jiang Wang, Wenjun Ni, Ming Poi, Christopher Coss, Zhongfa Liu, Mitch A Phelps, Amir Mortazavi, Leslie Andritsos, Robert A Baiocchi, Beth A Christian, Don M Benson, Joseph Flynn, Pierluigi Porcu, John C Byrd, Flavia Pichiorri, Craig C Hofmeister
Histone deacetylase inhibitors (HDACi) have proven activity in hematologic malignancies, and their FDA approval in multiple myeloma (MM) and T-cell lymphoma highlights the need for further development of this drug class. We investigated AR-42, an oral pan-HDACi, in a first-in-man phase 1 dose escalation clinical trial. Overall, treatment was well tolerated, no DLTs were evident, and the MTD was defined as 40 mg dosed three times weekly for three weeks of a 28-day cycle. One patient each with MM and mantle cell lymphoma demonstrated disease control for 19 and 27 months (ongoing), respectively...
March 7, 2017: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/28261699/effect-of-polylactic-film-surgi-wrap-on-preventing-postoperative-ileus-after-major-hepato-pancreato-biliary-surgery
#17
Chang Hyung Lee, Hongbeom Kim, In Woong Han, Suh Min Kim, Beom Seok Kwak, Yong Hae Baik, Young Jin Park, Min Gu Oh
BACKGROUNDS/AIMS: Major hepato-pancreato-biliary (HPB) surgery is usually performed via an open method rather than a laparoscopic method. Postoperative ileus (POI) is a classic complication after open surgery. The purpose of this study was to determine whether polylactic film is useful in the prevention of POI. METHODS: A total of 179 patients who underwent major HPB surgery between 2005 and 2014, were retrospectively reviewed. A diagnosis of POI was made by a physical examination, laboratory, and radiological findings...
November 2016: Ann Hepatobiliary Pancreat Surg
https://www.readbyqxmd.com/read/28258272/treatment-of-extrusive-luxation-in-permanent-teeth-literature-review-with-systematic-criteria
#18
Marina F Amaral, Melyna M de Almeida, Lorraine P de Faria, Daniela A Brandini, Wilson R Poi, Roberta Okamoto
INTRODUCTION: Extrusive luxation is a traumatic dental injury caused by the action of oblique forces, characterized by partial displacement of the tooth out of its socket. The ideal treatment for this type of trauma involves repositioning the tooth in its socket. However, in cases where the tooth cannot be repositioned, different options may be considered, such as intentional reattachment and orthodontic intrusion. The aim is to review the literature on the extrusive luxation of permanent teeth while assessing the risks of complications for two methods of delayed treatment for extrusive luxation...
March 1, 2017: Journal of Contemporary Dental Practice
https://www.readbyqxmd.com/read/28257537/primary-ovarian-insufficiency-current-concepts
#19
Gretchen Collins, Bansari Patel, Suruchi Thakore, James Liu
A potential consequence of chemotherapy is the destruction of oocytes, resulting in primary ovarian insufficiency (POI) in young patients; this often results in secondary amenorrhea and necessitates hormone replacement therapy. Regardless of the etiology of POI, the chance of pregnancy is low in this patient population. Given the extent to which oocyte depletion or dysfunction is variable, there is the possibility of spontaneous ovulation on hormone replacement therapy and subsequent pregnancy, however. If pregnancy is not desired, contraception always should be discussed...
March 2017: Southern Medical Journal
https://www.readbyqxmd.com/read/28250725/autoimmune-premature-ovarian-failure
#20
REVIEW
Beata Komorowska
Premature ovarian failure (POF), also termed as primary ovarian insufficiency (POI), is a highly heterogenous condition affecting 0.5-3.0% of women in childbearing age. These young women comprise quite a formidable group with unique physical and psychological needs that require special attention. Premature ovarian senescence (POS) in all of its forms evolves insidiously as a basically asymptomatic process, leading to complete loss of ovarian function, and POI/POF diagnoses are currently made at relatively late stages...
December 2016: Przeglad Menopauzalny, Menopause Review
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