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K J Juárez-Rendón, J E García-Ortiz
PURPOSE: Primary ovarian insufficiency (POI) is a clinical condition observed in women younger than 40 years of age, characterized by amenorrhea, hypoestrogenism, high levels of follicle-stimulating hormone (FSH), and infertility. Mutations in some master regulators of the development, maturation, and maintenance of ovarian follicles such as BMP15, FSHR, FOXL2, and GDF9 have been suggested as etiological factors in the development of POI. The aim of this study, the first in the Mexican population, is to evaluate the presence of mutations or polymorphisms in these four candidate genes...
June 18, 2018: Journal of Assisted Reproduction and Genetics
Beili Chen, Lin Li, Jing Wang, Tengyan Li, Hong Pan, Beihong Liu, Yiran Zhou, Yunxia Cao, Binbin Wang
BACKGROUND: To dissect the genetic alteration in two sisters with premature ovarian insufficiency (POI) from a consanguineous family. METHODS: Whole-exome sequencing technology was used in the POI proband, bioinformatics analysis was carried out to identify the potential genetic cause in this pedigree. Sanger sequencing analyses were performed to validate the segregation of the variant within the pedigree. In silico analysis was also used to predict the effect and pathogenicity of the variant...
June 18, 2018: Journal of Ovarian Research
Bernard Gottschalk
To find a deterministic pencil beam algorithm that computes, from first principles, the dose in some region of interest when a known heterogeneous terrain is irradiated by known proton beams.
 Methods: The terrain is discretized into slabs perpendicular to the nominal beam direction. Pencil beams (PBs) are transported through each slab using generalized Fermi-Eyges theory with the correct stopping and scattering powers for each material (no water-like assumption).
 At transverse heterogeneities PBs are divided into smaller ones using either redefinition (all PBs divided) or dynamic splitting (PBs divided one at a time as needed)...
June 14, 2018: Physics in Medicine and Biology
Steven Satterly, Owen McGrane, Thomas Frawley, William Bynum, John Martin, Charles Clegg, Nate Pearsall, Sean Reilly, Eric Verwiebe, Matthew Eckert
Hemorrhage in the presurgical setting has been the most significant cause of death on the battlefield. Damage control surgery (DCS) near the point of injury (POI) is not a new concept, but having conventional medical teams supporting Special Operations Forces (SOF) beyond robust military medical infrastructure is unique for the US military. The Expeditionary Resuscitative Surgical Team (ERST) was formed by the US Army Medical Command as a pilot team to fulfill a request for forces to provide DCS and personnel recovery near POI...
2018: Journal of Special Operations Medicine: a Peer Reviewed Journal for SOF Medical Professionals
Susann Karlberg, Aila Tiitinen, Henrik Alfthan, Marita Lipsanen-Nyman
STUDY QUESTION: What is the timing of onset and clinical course of premature ovarian insufficiency (POI) in patients with Mulibrey nanism (MUL), a monogenic disorder caused by mutations of the peroxisomal TRIM37 gene? SUMMARY ANSWER: The number of ovarian follicles is highly reduced already in infant and young MUL girls and the majority of them will have early depletion of follicles resulting in clinical and biochemical signs of POI. WHAT IS KNOWN ALREADY: Both female and male patients with MUL show failure of sexual maturation, signs of hypogonadism and infertility...
June 1, 2018: Human Reproduction
Ning Li, Lili Liu
AIM: To investigate the mechanism of resveratrol treatment in chemically induced premature ovarian insufficiency (POI) in rats. METHODS: Five-week-old specific pathogen-free healthy Sprague-Dawley female rats (n = 90) were randomly divided into five groups (n = 18): low-dose resveratrol (group A), moderate-dose resveratrol (group B), high-dose resveratrol (group C), model control group (group D) and blank control group (group E). POI was induced in rats from the resveratrol-treated groups and the model control group according to observed indexes using a previously established model (oral administration of tripterygium wilfordii polyglycoside tablet 50 mg/kg/day for 14 days)...
May 30, 2018: Journal of Obstetrics and Gynaecology Research
Carolina Carlosama, Liliana Catherine Patiño, Isabelle Beau, Adrien Morel, Brigitte Delemer, Jacques Young, Nadine Binart, Paul Laissue
Recently, it has been reported the first mutation in the KHDRBS1 gene related to primary ovarian insufficiency (POI) aetiology. Next generation sequencing (whole-exome sequencing-WES) experiments were performed in that study involving a familial case of POI (mother and daughter); this led to proposing that KHDRBS1-c.263C>T (p.Pro88Leu) and c.460A>G (pMet154Val) heterozygous sequence variants could be related to the phenotype. KHDRBS1 (also called Sam68) is an RNA-binding protein participating in several key cell processes, such as pre-mRNA splicing, mRNA translation, cell cycle regulation, signal transduction and apoptosis...
May 28, 2018: Clinical Endocrinology
Wesley M Durand, Jack H Ruddell, Adam E M Eltorai, J Mason DePasse, Alan H Daniels
BACKGROUND: Postoperative ileus (POI) is a common complication after spine surgery, with particularly high rates after adult spinal deformity surgery (ASD). Few investigations have been conducted, however, on predictors of POI following ASD. The objective of this investigation was to determine risk factors for POI in patients undergoing ASD. We also sought to determine the association between POI and in-hospital mortality, length of stay, and total charges. METHODS: Data were obtained from the National/Nationwide Inpatient Sample, years 2010 - 2014...
May 23, 2018: World Neurosurgery
Weiming Wang, Yang Wang, Jiani Wu, Likun Yang, Zhishun Liu
OBJECTIVE: To explore the effects of electroacupuncture (EA) at "Zhongliao" (BL 33) and "Tianshu" (ST 25) on ovarian function in rats with premature ovarian insufficiency (POI). METHODS: A total of 48 SD female rats with regular estrus were divided into a blank group ( n =8), a model group ( n =10), an EA group ( n =10), a binding group ( n =10) and a tamoxifen (TAM) group ( n =10). The rats in the model group, EA group, binding group and TAM group were all treated with intraperitoneal injection of 4-vinylcyclohexene diepoxide (VCD, 160 mg/kg) for 15 consecutive days to establish the model of POI; the rats in the blank group were treated with normal diet...
May 12, 2018: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
Brooke C Schneider, Johanna Schröder, Thomas Berger, Fritz Hohagen, Björn Meyer, Christina Späth, Wolfgang Greiner, Martin Hautzinger, Wolfgang Lutz, Matthias Rose, Eik Vettorazzi, Steffen Moritz, Jan Philipp Klein
BACKGROUND: Psychological online interventions (POIs) for depression have demonstrated promising effects. However, there are fewer randomized controlled studies on POIs among older adults with depression. The goal of the present study was to compare the use and efficacy of Deprexis, an online intervention for depression, among Millennials (18-35 years) and Baby Boomers (50-65 years). METHODS: We completed a secondary data analysis on a subset (N = 577) of participants in the EVIDENT trial, a parallel-groups, pragmatic, randomized, controlled single-blind study, which compared a 12-week POI (Deprexis) to care as usual (CAU)...
April 22, 2018: Journal of Affective Disorders
Israel Fernandez-Pineda, Andrew M Davidoff, Lu Lu, Bhaskar N Rao, Carmen L Wilson, D Kumar Srivastava, James L Klosky, Monica L Metzger, Matthew J Krasin, Kirsten K Ness, Ching-Hon Pui, Leslie L Robison, Melissa M Hudson, Charles A Sklar, Daniel M Green, Wassim Chemaitilly
BACKGROUND: We reviewed the effect of ovarian transposition (OT) on ovarian function among long-term survivors of childhood Hodgkin lymphoma (HL) treated with pelvic radiotherapy. PROCEDURE: Female participants (age 18+ years) with HL in the St. Jude Lifetime Cohort Study (SJLIFE) were clinically evaluated for premature ovarian insufficiency (POI) 10 or more years after pelvic radiotherapy. Reproductive history including age at menopause and pregnancy/live births was available on all patients...
May 11, 2018: Pediatric Blood & Cancer
Denise Pedrini, Sônia Regina Panzarini, Adelisa Rodolfo Ferreira Tiveron, Valéria Marisel de Abreu, Celso Koogi Sonoda, Wilson Roberto Poi, Daniela Atili Brandini
Objectives This study evaluated the evolution of cases of concussion and subluxation through a retrospective study of 20 years. Material and Methods Were examined clinical and radiographic records of 1,309 patients who underwent treatment of dentoalveolar trauma in the discipline of Integrated Clinic of the School of Dentistry of Araçatuba, UNESP, of which we selected 137 whose patients had concussion and subluxation injuries, with average age of 23.3 (SD - 10.96). The variables collected were: gender, age, history of previous and actual trauma, treatments performed, the presence of necrotic pulp, and time elapsed until the same trauma...
2018: Journal of Applied Oral Science: Revista FOB
Shiwei Wu, Lujun Yu, Xiaozhe Fu, Xi Yan, Qiang Lin, Lihui Liu, Hongru Liang, Ningqiu Li
Infectious spleen and kidney necrosis virus (ISKNV) has caused significant losses in the cultured mandarin fish (Siniperca chuatsi) industry. The molecular mechanisms that underlie interaction between ISKNV and hosts are not fully understood. In this study, the proteomic profile of CPB cells at progressive time points after ISKNV infection was analyzed by isobaric tags for relative and absolute quantitation (iTRAQ). A total of 2731 proteins corresponding to 6363 novel peptides (false discovery rate <0.01) were identified...
May 4, 2018: Fish & Shellfish Immunology
Manjunatha Kogenaru, Mark Isalan
Destabilizing domains (DDs) are genetic tags that conditionally control the level of abundance of proteins-of-interest (POI) with specific stabilizing small-molecule drugs, rapidly and reversibly, in a wide variety of organisms. The amount of the DD-tagged fusion protein directly impacts its molecular function. Hence, it is important that the background levels be tightly regulated in the absence of any drug. This is especially true for classes of proteins that function at extremely low levels, such as lethality genes involved in tissue development and certain transcriptional activator proteins...
May 7, 2018: ACS Synthetic Biology
Lise Courtot, Bertrand Le Roy, Ricardo Memeo, Thibault Voron, Nicolas de Angelis, Nicolas Tabchouri, Francesco Brunetti, Anne Berger, Didier Mutter, Johan Gagniere, Ephrem Salamé, Denis Pezet, Mehdi Ouaïssi
PURPOSE: Postoperative ileus (POI) is associated with an elevated risk of other complications and increases the economic impact on healthcare services. The aim of this study was to identify pre-, intra- and postoperative risk factors associated with the development of POI following elective laparoscopic right colectomy. METHODS: Between 2004 and 2016, 637 laparoscopic right colectomies were performed. Data were analysed retrospectively thanks to the CLIHMET database...
May 7, 2018: International Journal of Colorectal Disease
Haibo Wang, Hanjie Chen, Ming Cai
The primary objective of this study was to develop an evaluation method for assessing an urban traffic noise-exposed population and apply it in the main urban area of Guangzhou. The method based on points of interest (POIs) and noise map is realized in several steps. First, after regionalizing based on road networks and executing a cluster analysis for regions according to the properties of POIs, the environmental noise functional regions (NFRs) of the urban area are presented. Then, surrounding POIs are used to infer the type of buildings, and according to the attraction of different building types and the whole population of the region, the population distribution at the building level is calculated...
May 2, 2018: Environmental Pollution
Katie L Moore, Ildefonso Rodríguez-Ramiro, Eleanor R Jones, Emily J Jones, Jorge Rodríguez-Celma, Kirstie Halsey, Claire Domoney, Peter R Shewry, Susan Fairweather-Tait, Janneke Balk
Pea seeds are widely consumed in their immature form, known as garden peas and petit pois, mostly after preservation by freezing or canning. Mature dry peas are rich in iron in the form of ferritin, but little is known about the content, form or bioavailability of iron in immature stages of seed development. Using specific antibodies and in-gel iron staining, we show that ferritin loaded with iron accumulated gradually during seed development. Immunolocalization and high-resolution secondary ion mass spectrometry (NanoSIMS) revealed that iron-loaded ferritin was located at the surface of starch-containing plastids...
May 2, 2018: Scientific Reports
Matteo Lambertini, Halle C F Moore, Robert C F Leonard, Sibylle Loibl, Pamela Munster, Marco Bruzzone, Luca Boni, Joseph M Unger, Richard A Anderson, Keyur Mehta, Susan Minton, Francesca Poggio, Kathy S Albain, Douglas J A Adamson, Bernd Gerber, Amy Cripps, Gianfilippo Bertelli, Sabine Seiler, Marcello Ceppi, Ann H Partridge, Lucia Del Mastro
Purpose The role of temporary ovarian suppression with gonadotropin-releasing hormone agonists (GnRHa) during chemotherapy as a strategy to preserve ovarian function and fertility in premenopausal women remains controversial. This systematic review and meta-analysis using individual patient-level data was conducted to better assess the efficacy and safety of this strategy in patients with early breast cancer. Methods The trials in which premenopausal women with early breast cancer were randomly assigned to receive (neo)adjuvant chemotherapy alone or with concurrent GnRHa were eligible for inclusion...
May 2, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
Yan Ding, Jia-Liang Shao, Jun-Wei Li, Ying Zhang, Kai-Hua Hong, Ke-Qin Hua, Xiang Wang
BACKGROUND: Fertility preservation by whole ovary cryopreservation and transplantation (WOCP&TP) with vascular anastomosis requires successful cryopreservation. In this study, we investigated the possibility of restoring ovarian function and natural fertility after WOCP&TP in a premature ovarian insufficiency (POI) rat model. The influence of cryopreservation on the offspring of rats following WOCP&TP was also explored. METHOD: Rats aged 8-10 weeks were used as donors and recipients for allotransplantation...
May 2, 2018: Journal of Ovarian Research
Elena J Tucker, Sonia R Grover, Gorjana Robevska, Jocelyn van den Bergen, Chloe Hanna, Andrew H Sinclair
Next-generation sequencing (NGS) is increasingly being used in a clinical setting for the molecular diagnosis of patients with heterogeneous disorders, such as premature ovarian insufficiency (POI). We performed NGS of ~1000 candidate genes in four unrelated patients with POI. We discovered the genetic cause of "isolated" POI in two cases, both of which had causative variants in surprising genes. In the first case, a homozygous nonsense variant in NBN was causative. Recessive function-altering NBN variants typically cause Nijmegen breakage syndrome characterized by microcephaly, cancer predisposition, and immunodeficiency, none of which are evident in the patient...
April 30, 2018: European Journal of Human Genetics: EJHG
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