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https://www.readbyqxmd.com/read/27916452/the-normal-range-of-fmr1-triple-cgg-repeats-may-be-associated-with-primary-ovarian-insufficiency-in-china
#1
Cui-Ling Lu, Rong Li, Xin-Na Chen, Yang-Ying Xu, Li-Ying Yan, Jie Yan, Yao-Yao Zhang, Hong-Yan Jin, Wen-Xin Zhang, Jie Qiao, Xiu-Mei Zhen
The aim of this study was to investigate the relationship between normal Fragile X mental retardation gene 1 (FMR1) CGG repeat numbers and primary ovarian insufficiency (POI) occurrence or subsequent resumption of ovarian function. A total of 122 women with POI and 105 controls were followed up and analysed in our centre. The prevalence of premutation and intermediate range of FMR1 CGG repeats in Han Chinese women with POI was only 0.81% (1/122) and 1.64% (2/122), respectively. The risk of POI occurrence for less than 26 CGG repeats and 29 or more CGG repeats in allele1 (smaller allele) was significantly higher than that for 26-28 CGG repeats (odds ratio 13...
November 15, 2016: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/27914997/transcriptomic-profiles-of-striped-snakehead-fish-cells-ssn-1-infected-with-red-spotted-grouper-nervous-necrosis-virus-rgnnv-with-an-emphasis-on-apoptosis-pathway
#2
Wenjie Chen, Lizhu Yi, Shuangshuang Feng, Xiaodan Liu, Muhammad Asim, Yongcan Zhou, Jiangfeng Lan, Sanjie Jiang, Jiagang Tu, Li Lin
Nervous necrosis virus (NNV), the causative agent of viral nervous necrosis (VNN) disease, has caused mass mortality of cultured marine and freshwater fish worldwide, resulting in enormous economic losses in the aquaculture industry. However, the molecular mechanisms underlying the pathogenicity of NNV are still poorly understood. In this study, the transcriptomic profiles of striped snakehead fish (Channa striatus) cells (SSN-1) infected with red-spotted grouper NNV (RGNNV) were investigated using deep RNA sequencing technique...
November 30, 2016: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/27912889/hormone-replacement-therapy-in-young-women-with-primary-ovarian-insufficiency-and-early-menopause
#3
REVIEW
Shannon D Sullivan, Philip M Sarrel, Lawrence M Nelson
Primary ovarian insufficiency (POI) is a rare but important cause of ovarian hormone deficiency and infertility in women. In addition to causing infertility, POI is associated with multiple health risks, including bothersome menopausal symptoms, decreased bone density and increased risk of fractures, early progression of cardiovascular disease, psychologic impact that may include depression, anxiety, and decreased perceived psychosocial support, potential early decline in cognition, and dry eye syndrome. Appropriate hormone replacement therapy (HRT) to replace premenopausal levels of ovarian sex steroids is paramount to increasing quality of life for women with POI and ameliorating associated health risks...
December 2016: Fertility and Sterility
https://www.readbyqxmd.com/read/27910707/standard-hormone-therapy-is-inadequate-for-bone-density-in-premature-ovarian-insufficiency
#4
Helena Giraldo, Cristina Benetti-Pinto, Valeska Ferreira, Heraldo Garmes, Daniela Yela, Paulo Giraldo
To assess standard dose hormone therapy (HT) and bone mass in premature ovarian insufficiency (POI), 239 women with POI, 132 using standard estrogen dose HT and 107 women without HT, were evaluated. All underwent bone mineral density (BMD) evaluation in the lumbar spine (LS) and total femur (TF). Mean age, age at last period and body mass index (BMI) for the untreated and for the HT groups were 38.1 ± 6.1 and 36.8 ± 7.3 years; 31.4 ± 7.3 and 30.7 ± 7.2 years; 26.6 ± 7.1 and 25.8 ± 4...
December 2, 2016: Gynecological Endocrinology
https://www.readbyqxmd.com/read/27906970/poor-compliance-to-hormone-therapy-and-decreased-bone-mineral-density-in-women-with-premature-ovarian-insufficiency
#5
Anne Bachelot, Carole Nicolas, Solenne Gricourt, Jérôme Dulon, Monique Leban, Jean Louis Golmard, Philippe Touraine
Premature ovarian insufficiency leads to through infertility and estrogen deficiency. Optimal management encompasses estrogen replacement therapy. Long-term outcome of women with POI is not known. We design a study to evaluate the medical care, hormone replacement therapy compliance and bone mineral density (BMD) in POI women with at least a five-year follow-up after the first evaluation. One hundred and sixty-two patients (37.3±8.0 years) were evaluated (follow-up 7.9±2.8 years). Sixty-nine patients (42...
2016: PloS One
https://www.readbyqxmd.com/read/27898025/identification-and-characterization-of-micrornas-in-the-liver-of-blunt-snout-bream-megalobrama-amblycephala-infected-by-aeromonas-hydrophila
#6
Lei Cui, Hongtao Hu, Wei Wei, Weimin Wang, Hong Liu
MicroRNAs (miRNAs) are small RNA molecules that play key roles in regulation of various biological processes. In order to better understand the biological significance of miRNAs in the context of Aeromonas hydrophila infection in Megalobrama amblycephala, small RNA libraries obtained from fish liver at 0 (non-infection), 4, and 24 h post infection (poi) were sequenced using Illumina deep sequencing technology. A total of 11,244,207, 9,212,958, and 7,939,157 clean reads were obtained from these three RNA libraries, respectively...
November 25, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27889442/current-perspectives-in-the-interpretation-of-gunshot-residues-in-forensic-science-a-review
#7
REVIEW
M Maitre, K P Kirkbride, M Horder, C Roux, A Beavis
The traces produced when a firearm is discharged can provide important information in cases when questions regarding a possible association of the firearm with a person of interest (POI), time since discharge or shooting distance are raised. With advances in technology, the forensic challenges presented by these traces, known as gunshot residues (GSR), are moving from the analytical domain to the interpretation of the analytical results. Different interpretation frameworks are currently competing. Formal classification of particles, using standards such as that produced by ASTM, focusses only on evaluation of evidence at the sub-source level...
September 22, 2016: Forensic Science International
https://www.readbyqxmd.com/read/27879048/coordinated-protein-co-expression-in-plants-by-harnessing-the-synergy-between-an-intein-and-a-viral-2a-peptide
#8
Bei Zhang, Madhusudhan Rapolu, Sandeep Kumar, Manju Gupta, Zhibin Liang, Zhenlin Han, Philip Williams, Wei Wen Su
A novel approach is developed for coordinated expression of multiple proteins from a single transgene in plants. An Ssp DnaE mini-intein variant engineered for hyper N-terminal autocleavage is covalently linked to the foot-and-mouth disease virus 2A (F2A) peptide with unique ribosome skipping property, via a peptide linker, to create an "IntF2A" self-excising fusion protein domain. This IntF2A domain acts, in cis, to direct highly effective release of its flanking proteins of interest (POI) from a "polyprotein" precursor in plants...
November 23, 2016: Plant Biotechnology Journal
https://www.readbyqxmd.com/read/27869718/endocrine-dysfunction-in-female-fmr1-premutation-carriers-characteristics-and-association-with-ill-health
#9
Sonya Campbell, Sarah E A Eley, Andrew G McKechanie, Andrew C Stanfield
Female FMR1 premutation carriers (PMC) have been suggested to be at greater risk of ill health, in particular endocrine dysfunction, compared to the general population. We set out to review the literature relating to endocrine dysfunction, including premature ovarian insufficiency (POI), in female PMCs, and then to consider whether endocrine dysfunction in itself may be predictive of other illnesses in female PMCs. A systematic review and pilot data from a semi-structured health questionnaire were used. Medline, Embase, and PsycInfo were searched for papers concerning PMCs and endocrine dysfunction...
November 18, 2016: Genes
https://www.readbyqxmd.com/read/27861765/genetics-of-primary-ovarian-insufficiency
#10
REVIEW
R Rossetti, I Ferrari, M Bonomi, L Persani
Primary ovarian insufficiency (POI) is characterized by a loss of ovarian function before the age of 40 and account for one major cause of female infertility. POI relevance is continuously growing because of the increasing number of women desiring conception beyond 30 years of age, when POI prevalence is >1%. POI is highly heterogeneous and can present with ovarian dysgenesis and primary amenorrhea, or with secondary amenorrhea, and it can be associated with other congenital or acquired abnormalities. In most cases POI remains classified as idiopathic...
November 16, 2016: Clinical Genetics
https://www.readbyqxmd.com/read/27861188/controversies-in-quantification-of-mitral-valve-regurgitation-role-of-cardiac-magnetic-resonance-imaging
#11
Kim A Connelly, Edwin C Ho, Howard Leong-Poi
PURPOSE OF REVIEW: Mitral regurgitation remains a common problem, and when severe, is associated with significant morbidity and mortality. At present, echocardiography remains the primary modality for assessing both mechanism and severity of mitral regurgitation. However, recent studies demonstrate that the echocardiographic assessment of mitral regurgitation severity may be subject to variability as a result of semiquantitative parameters, dependence upon loading conditions and significant interobserver variability...
November 18, 2016: Current Opinion in Cardiology
https://www.readbyqxmd.com/read/27858857/primary-amenorrhea-after-bone-marrow-transplantation-and-adjuvant-chemotherapy-misdiagnosed-as-disorder-of-sex-development-a-case-report
#12
He Huang, Qinjie Tian
INTRODUCTION: Disorders of sex development (DSD) is a congenital condition in which the development of chromosomal, gonadal or genital sex is atypical. Majority of patients present clinical characteristics of primary amenorrhea, absent secondary sex characters, and abnormal hormone level. A female appearance patient with primary amenorrhea and 46 XY karyotype seems to be solid evidences to diagnose Y-chromosome-related DSD diseases, while it is not necessarily the accurate diagnosis. We report the case of an 18-year-old girl with primary amenorrhea and 46 XY karyotype misdiagnosed as Y-chromosome-related DSD...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27836978/a-homozygous-nobox-truncating-variant-causes-defective-transcriptional-activation-and-leads-to-primary-ovarian-insufficiency
#13
Lin Li, Binbin Wang, Wei Zhang, Beili Chen, Minna Luo, Jing Wang, Xi Wang, Yunxia Cao, Kehkooi Kee
STUDY QUESTION: Does a novel homozygous NOBOX truncating variant, identified in whole exome sequencing (WES) of patients with primary ovarian insufficiency (POI), cause defective transcriptional activation of multiple oocyte-related genes? SUMMARY ANSWER: A novel homozygous truncating mutation of NOBOX was confirmed to exhibit a loss-of-function effect using well-defined molecular and functional analyses. WHAT IS KNOWN ALREADY: Several NOBOX mutations have been reported to be associated with POI but all of them are heterozygous mutations...
November 11, 2016: Human Reproduction
https://www.readbyqxmd.com/read/27836977/impaired-telomere-length-and-telomerase-activity-in-peripheral-blood-leukocytes-and-granulosa-cells-in-patients-with-biochemical-primary-ovarian-insufficiency
#14
Xiaofei Xu, Xinxia Chen, Xiruo Zhang, Yixun Liu, Zhao Wang, Peng Wang, Yanzhi Du, Yingying Qin, Zi-Jiang Chen
STUDY QUESTION: Are telomere length and telomerase activity associated with biochemical primary ovarian insufficiency (POI)? SUMMARY ANSWER: Shortened telomere length and diminished telomerase activity were associated with biochemical POI. WHAT IS KNOWN ALREADY: POI is a result of pathological reproductive aging and encompasses occult, biochemical and overt stages. Studies have indicated telomere length as a biomarker for biological aging...
November 11, 2016: Human Reproduction
https://www.readbyqxmd.com/read/27832682/effect-of-da-9701-a-novel-prokinetic-agent-on-postoperative-ileus-in-rats
#15
Sang Pyo Lee, Oh Young Lee, Kang Nyeong Lee, Hang Lak Lee, Ho Soon Choi, Byung Chul Yoon, Dae Won Jun
Background/Aims: Postoperative ileus (POI) is a common complication of abdominal surgery. DA-9701, an extract of Pharbitis Semen and Corydalis Tuber, is a new prokinetic agent that also alleviates visceral pain. The aim of this study was to investigate whether DA-9701 can ameliorate POI in rats. Methods: A total of 32 rats were divided into 4 groups: no surgery/no medication (NSNM), no surgery/medication (NSM), surgery/no medication (SNM), and surgery/medication (SM)...
November 10, 2016: Journal of Neurogastroenterology and Motility
https://www.readbyqxmd.com/read/27829492/forward-medevac-during-serval-and-barkhane-operations-in-sahel-a-registry-study
#16
Cyril Carfantan, Yvain Goudard, Christophe Butin, Sandrine Duron-Martinaud, Jean-Philippe Even, Anthony Anselme, Erwan Dulaurent, Mélanie Géhant, Vicky Vitalis, Christian Bay, Jérôme Bancarel, Julien Bordes
INTRODUCTION: The French army has been deployed in Mali since January 2013 with the Serval Operation and since July 2014 in the Sahel-Saharan Strip (SSS) with the Barkhane Operation where the distances (up to 1100km) can be very long. French Military Medical Service deploys an inclusive chain from the point of injury (POI) to hospital in France. A patient evacuation coordination cell (PECC) has been deployed since February 2013 to organise forward medical evacuation (MEDEVAC) in the area between the POI and three forward surgical units...
November 4, 2016: Injury
https://www.readbyqxmd.com/read/27828684/development-policy-for-the-brazilian-health-industry-and-qualification-of-national-public-laboratories
#17
Ana Luiza d'Ávila Viana, Hudson Pacifico da Silva, Nelson Ibañez, Fabíola Lana Iozzi
Technological innovations play a decisive role in societies' development by contributing to economic growth and the population's welfare. The state has a key role in this process by inducing innovative behavior, strategies, and decisions. This study addresses Brazil's current policy for development of the health industry and its effects on qualification of national public laboratories by contextualizing different cycles of interaction between health policy and the industrial base, discussing the government's development strategy and the transfer and absorption of health technology (through Industrial Development Partnerships), and presenting two current partnerships involving public laboratories in the production of medicines and vaccines...
November 3, 2016: Cadernos de Saúde Pública
https://www.readbyqxmd.com/read/27828674/development-health-and-international-policy-the-research-and-innovation-dimension
#18
Paulo Marchiori Buss, Claudia Chamas, Miriam Faid, Carlos Morel
This text main objective is to discuss development and health from the perspective of the influence of global health governance, using as the tracer the dimension of research, development, and innovation policies in health, which relate to both important inputs for the health system, like drugs and medicines, vaccines, diagnostic reagents, and equipment, and innovative concepts and practices for the improvement of health systems and public health. The authors examine the two main macro-processes that influence development and health: the post-2015 Development Agenda and the process under way in the World Health Organization concerning research and development, intellectual property, and access to health inputs...
November 3, 2016: Cadernos de Saúde Pública
https://www.readbyqxmd.com/read/27825820/the-upregulation-of-immune-responses-in-tyrosine-hydroxylase-th-silenced-litopenaeus-vannamei
#19
Ratchaneegorn Mapanao, Chin-Chyuan Chang, Winton Cheng
Catecholamines (CAs) play a crucial role in maintaining physiological and immune homeostasis in invertebrates and vertebrates under stressful conditions. Tyrosine hydroxylase (TH) is the first and rate-limiting enzyme in CA synthesis. To develop an effective CA-related immunological defense system against stress and pathogen infection, various criteria, were evaluated in TH double-stranded (ds) RNA-injected white shrimp, Litopenaeus vannamei. Specifically, the relative transcript quantification of TH, dopamine β-hydroxylase (DBH), crustacean hyperglycemic hormone (CHH), and other immune-related genes; TH activity in the haemolymph; and the estimation of l-dihydroxyphenylalanine (l-DOPA), glucose, and lactate levels in the haemolymph were examined...
February 2017: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/27816926/a-mother-s-gift-of-life-exploring-the-concerns-and-ethical-aspects-of-fertility-preservation-for-mother-to-daughter-oocyte-donation
#20
REVIEW
E M E Balkenende, W Dondorp, M C Ploem, C B Lambalk, M Goddijn, F Mol
With the introduction of oocyte vitrification, a special form of intergenerational intrafamilial medically assisted reproduction (IMAR) has now become feasible: fertility preservation for mother-to-daughter oocyte donation (FPMDD). For girls diagnosed with premature ovarian insufficiency (POI), banking of their mothers' oocytes can preserve the option of having genetically related offspring. Since policy documents on IMAR do not discuss specific concerns raised by FPMDD, clinicians can feel at a loss for guidance with regard to handling these requests...
November 5, 2016: Human Reproduction
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