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https://www.readbyqxmd.com/read/28342753/evaluation-of-chitosan-as-a-wall-material-for-microencapsulation-of-squalene-by-spray-drying-characterization-and-oxidative-stability-studies
#1
Lekshmi R G Kumar, N S Chatterjee, C S Tejpal, K V Vishnu, K K Anas, K K Asha, R Anandan, Suseela Mathew
The present study was aimed at investigating the efficacy of chitosan as a wall material for microencapsulation of squalene by spray drying for functional food applications. Based on different core to wall material ratio (1:1, 0.5:1 and 0.3:1 on w/w basis), emulsions were prepared and evaluated in terms of emulsion stability, particle size, zeta potential, polydispersity Index (PDI), rheology and microstructure. The optimized emulsion combination was spray dried and characterized, physically and chemically...
March 22, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28302155/a-prospective-randomised-placebo-controlled-double-masked-three-armed-multicentre-phase-ii-iii-trial-for-the-study-of-a-topical-treatment-of-ischaemic-central-retinal-vein-occlusion-to-prevent-neovascular-glaucoma-the-strong-study-study-protocol-for-a-randomised
#2
Katrin Lorenz, Yvonne Scheller, Katharina Bell, Franz Grus, Katharina A Ponto, Felix Bock, Claus Cursiefen, Jens Flach, Marta Gehring, Tunde Peto, Rufino Silva, Yossi Tal, Norbert Pfeiffer
BACKGROUND: Neovascular glaucoma (NVG) is rare, comprising only 3.9% of all glaucoma cases. The most common cause of NVG is ischaemic central retinal vein occlusion (iCRVO). NVG frequently results in blindness and painful end-stage glaucomatous damage leading to the need for enucleation. Currently, there is no preventive therapy for NVG following iCRVO. Rescue treatments have severe drawbacks. Accordingly, there is a great need for preventing the often visually devastating outcomes of NVG...
March 16, 2017: Trials
https://www.readbyqxmd.com/read/28298672/optimization-low-fat-and-low-cholesterol-mayonnaise-production-by-central-composite-design
#3
H R Mozafari, E Hosseini, M Hojjatoleslamy, G Hossein Mohebbi, N Jannati
In this study, the optimized process variables for mayonnaise low in cholestrol and fat, which contained soy milk as a yolk substitute with different levels of Xanthan gum, Zodo gum, and oil, were determined by response surface methodology using a central composite design. Polynomial equation was fitted with an insignificant lack of fit factor in order to study the relationship between variables and responses including apparent viscosity, consistency coefficient, flow index, firmness, and stability of mayonnaise sauces...
March 2017: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/28271329/stabilization-improves-theranostic-properties-of-lipiodol-%C3%A2-based-emulsion-during-liver-trans-arterial-chemo-embolization-in-a-vx2-rabbit-model
#4
F Deschamps, G Farouil, W Gonzalez, C Robic, A Paci, L M Mir, L Tselikas, T de Baère
PURPOSE: To demonstrate that stability is a crucial parameter for theranostic properties of Lipiodol(®)-based emulsions during liver trans-arterial chemo-embolization. MATERIALS AND METHODS: We compared the theranostic properties of two emulsions made of Lipiodol(®) and doxorubicin in two successive animal experiments (One VX2 tumour implanted in the left liver lobe of 30 rabbits). Emulsion-1 reproduced one of the most common way of preparation (ratio of oil/water: 1/1), and emulsion-2 was designed to obtain a water-in-oil emulsion with enhanced stability (ratio of oil/water: 3/1, plus an emulsifier)...
March 7, 2017: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/28216792/effect-of-monomer-solubility-on-the-evolution-of-copolymer-morphology-during-polymerization-induced-self-assembly-in-aqueous-solution
#5
Amy A Cockram, Thomas J Neal, Matthew J Derry, Oleksandr O Mykhaylyk, Neal S J Williams, Martin W Murray, Simon N Emmett, Steven P Armes
Polymerization-induced self-assembly (PISA) has become a widely used technique for the rational design of diblock copolymer nano-objects in concentrated aqueous solution. Depending on the specific PISA formulation, reversible addition-fragmentation chain transfer (RAFT) aqueous dispersion polymerization typically provides straightforward access to either spheres, worms, or vesicles. In contrast, RAFT aqueous emulsion polymerization formulations often lead to just kinetically-trapped spheres. This limitation is currently not understood, and only a few empirical exceptions have been reported in the literature...
February 14, 2017: Macromolecules
https://www.readbyqxmd.com/read/28183171/impacts-of-post-mortem-ageing-prior-to-freezing-on-technological-and-oxidative-properties-of-coarse-ground-lamb-sausage-in-a-model-system
#6
Ju-Hui Cho, Hyun-Wook Kim, Mustafa M Farouk, Yuan H Brad Kim
Objective: The objective of this study was to evaluate the effects of ageing time of lamb loins prior to freezing on technological characteristics and oxidation stability of coarse ground lamb loin sausage using in a model system. Methods: Lamb loins (M. longissimus lumborum, n=25) were aged at -1.5ºC for 0, 1, 2, 3 and 8 wk and then frozen for the remaining days (a total of 30 wk). The aged/frozen/thawed lamb loins were ground, and model sausages were formulated with 75% aged/frozen/thawed lamb loin, 25% water, 1...
January 26, 2017: Asian-Australasian Journal of Animal Sciences
https://www.readbyqxmd.com/read/28159255/amorphous-nano-curcumin-stabilized-oil-in-water-emulsion-physico-chemical-characterization
#7
N P Aditya, Ian E Hamilton, Ian T Norton
Particle characteristics e.g. size and polymorphism are known to significantly affect the Pickering ability of the solid particles by influencing their interaction at the oil and water (O/W) interface. In this study, nano-sized amorphous curcumin particles were fabricated using nanonization technology to use them as Pickering particles. After nanonization, native crystalline curcumin particles were converted into amorphous, nanosized particles of ∼220nm. Amorphous nature of the particle was evident from the decreased melting point from 177±1°C (native curcumin) to 146±3°C (nanonized curcumin) and enthalpy from 27±2J/g to 3...
June 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28156159/cholesterol-peg-comodified-poly-n-butyl-cyanoacrylate-nanoparticles-for-brain-delivery-in-vitro-and-in-vivo-evaluations
#8
Xiao Hu, Feifei Yang, Yonghong Liao, Lin Li, Lan Zhang
This study investigated cholesterol-polyethylene glycol (PEG) comodified poly (ethyleneglycol)-poly (lactide) nanoparticles (CLS-PEG NPs) as a novel, biodegradable brain drug delivery system and included an evaluation of its in vitro and in vivo properties. To this end, coumarin-6 (C6), a fluorescent probe, was encapsulated into CLS-PEG NPs by an emulsion polymerization method. We reported that the use of CLS-PEG NPs led to a sustained drug release in vitro. Additionally, cell viability experiments confirmed their safety...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/28123298/oxygen-and-indocyanine-green-loaded-phase-transition-nanoparticle-mediated-photo-sonodynamic-cytotoxic-effects-on-rheumatoid-arthritis-fibroblast-like-synoviocytes
#9
Qin Tang, Jianyu Cui, Zhonghua Tian, Jiangchuan Sun, Zhigang Wang, Shufang Chang, Shenyin Zhu
BACKGROUND: Photodynamic therapy and sonodynamic therapy are developing, minimally invasive, and site-specific modalities for cancer therapy. A combined strategy PSDT (photodynamic therapy followed by sonodynamic therapy) has been proposed in this study. Here, we aimed to develop novel biodegradable poly(DL-lactide-co-glycolic acid) phase-transition nanoparticles simultaneously loaded with oxygen and indocyanine green (OI-NPs) and to investigate the cytotoxic effects and the potential mechanisms of OI-NP-mediated PSDT on MH7A synoviocytes...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28121666/tenofovir-alafenamide-and-elvitegravir-loaded-nanoparticles-for-long-acting-prevention-of-hiv-1-vaginal-transmission
#10
Subhra Mandal, Pavan K Prathipati, Guobin Kang, You Zhou, Zhe Yuan, Wenjin Fan, Qingsheng Li, Christopher J Destache
OBJECTIVE: This report presents tenofovir (TFV) alafenamide (TAF) and elvitegravir (EVG) fabricated into nanoparticles for subcutaneous delivery as prevention strategy. DESIGN: Prospective prevention study in humanized bone marrow-liver-thymus (hu-BLT) mice. METHODS: Using an oil-in-water emulsion solvent evaporation technique, TAF + EVG drugs were entrapped together into nanoparticles containing poly(lactic-co-glycolic acid). In-vitro prophylaxis studies (90% inhibition concentration) compared nanoparticles with drugs in solution...
February 20, 2017: AIDS
https://www.readbyqxmd.com/read/28044232/lipid-emulsions-containing-medium-chain-triacylglycerols-blunt-bradykinin-induced-endothelium-dependent-relaxation-in-porcine-coronary-artery-rings
#11
Said Amissi, Julie Boisramé-Helms, Mélanie Burban, Sherzad K Rashid, Antonio J León-González, Cyril Auger, Florence Toti, Ferhat Meziani, Valérie B Schini-Kerth
Lipid emulsions for parenteral nutrition are used to provide calories and essential fatty acids for patients. They have been associated with hypertriglyceridemia, hypercholesterolemia, and metabolic stress, which may promote the development of endothelial dysfunction in patients. The aim of the present study was to determine whether five different industrial lipid emulsions may affect the endothelial function of coronary arteries. Porcine coronary artery rings were incubated with lipid emulsions 0.5, 1, or 2% (v/v) for 30 min before the determination of vascular reactivity in organ chambers and the level of oxidative stress using electron paramagnetic resonance...
March 2017: Lipids
https://www.readbyqxmd.com/read/28032304/l-carnitine-reduces-susceptibility-to-bupivacaine-induced-cardiotoxicity-an-experimental-study-in-rats
#12
Gail K Wong, Carolyne Pehora, Mark W Crawford
BACKGROUND: The primary aim of this study was to evaluate the effect of acute administration of L-carnitine 100 mg·kg(-1) iv on susceptibility to bupivacaine-induced cardiotoxicity in rats. METHODS: In the first of two experiments, L-carnitine 100 mg·kg(-1) iv (n = 10) or saline iv (n = 10) was administered to anesthetized and mechanically ventilated Sprague-Dawley rats following which an infusion of bupivacaine 2.0 mg·kg(-1)·min(-1) iv was given until asystole occurred...
March 2017: Canadian Journal of Anaesthesia, Journal Canadien D'anesthésie
https://www.readbyqxmd.com/read/28028728/tissue-concentration-of-dodecafluoropentane-ddfp-following-repeated-iv-administration-in-the-new-zealand-white-rabbit
#13
Christine Arthur, Lin Song, William Culp, Aliza Brown, Michael Borrelli, Robert Skinner, Howard Hendrickson
IV injection of dodecafluoropentane emulsion (DDFPe) increases oxygen transportation and reduces brain infarct volume in a rabbit stroke model. Tissue distribution of the parent perfluorocarbon dodecafluoropentane (DDFP) is unknown but is critical to understanding the mechanism by which DDFPe is effective in treating ischemia and for determining safe dosing. Previous studies showed a DDFP blood half-life of <2 min yet therapeutic effects lasted >90 min after injection. We describe DDFP distribution in brain, kidney, liver, spleen, and lung following nine dosing regimens in New Zealand White (NZW) rabbits...
March 2017: AAPS Journal
https://www.readbyqxmd.com/read/27898794/greenhouse-gas-emissions-from-solid-and-liquid-organic-fertilizers-applied-to-lettuce
#14
Phasita Toonsiri, Stephen J Del Grosso, Arina Sukor, Jessica G Davis
Improper application of nitrogen (N) fertilizer and environmental factors can cause the loss of nitrous oxide (NO) to the environment. Different types of fertilizers with different C/N ratios may have different effects on the environment. The focus of this study was to evaluate the effects of environmental factors and four organic fertilizers (feather meal, blood meal, fish emulsion, and cyano-fertilizer) applied at different rates (0, 28, 56, and 112 kg N ha) on NO emissions and to track CO emissions from a lettuce field ( L...
November 2016: Journal of Environmental Quality
https://www.readbyqxmd.com/read/27875287/two-year-follow-up-of-a-randomized-controlled-nutrition-intervention-trial-in-very-low-birth-weight-infants
#15
Jorine A Roelants, Hester Vlaardingerbroek, Chris H P van den Akker, Rogier C J de Jonge, Johannes B van Goudoever, Marijn J Vermeulen
BACKGROUND: Very low-birth-weight (VLBW) infants are at risk for neurodevelopment impairment. This study assessed the effect of early aggressive parenteral nutrition (PN) on long-term outcome in VLBW infants. MATERIALS AND METHODS: Directly after birth, VLBW infants (birth weight <1500 g, n = 142) were randomized to 5 different PN regimes. Controls (n = 46) received glucose and standard-dose amino acids (AAs; 2.4 g/[kg·d]) from birth onward and pure soybean oil fat emulsion (SOY) on the second day of life...
November 10, 2016: JPEN. Journal of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/27859401/biochemical-and-molecular-characterization-of-a-lipase-from-an-algerian-isolated-staphylococcus-aureus-strain
#16
Fatima Nehal, Raida Jallouli, Najeh Krayem, Madiha Bou Ali, Abdelkader Dilmi Bouras, Ahmed Fendri, Youssef Gargouri
A Staphylococcus aureus strain, isolated from an Algerian biotope, secretes a non-induced lipase in the culture medium. The S. aureus lipase (SAL) was purified to homogeneity. Pure SAL is a monomeric protein (43 kDa). The 20 N-terminal amino acid residues showed a high degree of homology with other staphylococcal lipase sequences. SAL presents specific activities of about 1600 and 555 U mg(-1) using tributyrin and olive oil emulsion as substrates, respectively. In contrast to other staphylococcal lipases previously characterized, SAL was stable at a pH range from 6 to 9 after 1 h incubation, and retained 50% of its activity after 10 min incubation at 50 °C...
March 2017: Journal of Basic Microbiology
https://www.readbyqxmd.com/read/27858037/dual-responsive-pickering-emulsions-stabilized-by-constructed-core-crosslinked-polymer-nanoparticles-via-reversible-covalent-bonds
#17
Huazhang Guo, Duanguang Yang, Mei Yang, Yong Gao, Yijiang Liu, Huaming Li
In this study, pH- and glucose-responsive Pickering emulsions stabilized by core crosslinked polymer nanoparticles, which were constructed via reversible covalent bonds, were presented for the first time. Firstly, well-defined PDMA-b-PAPBA (poly(N,N-dimethylacrylamide)-b-poly(3-acrylamidophenylboronic acid)) diblock copolymers were synthesized via sequential reversible addition-fragmentation chain transfer (RAFT) polymerization reactions. By means of complexation of PBA units of PDMA-b-PAPBA with PVA in basic water, core crosslinked polymer nanoparticles (CCPNs) with a core-shell structure were formed...
December 6, 2016: Soft Matter
https://www.readbyqxmd.com/read/27783521/co2-triggered-pickering-emulsion-based-on-silica-nanoparticles-and-tertiary-amine-with-long-hydrophobic-tails
#18
Yongmin Zhang, Shuang Guo, Wentao Wu, Zhirong Qin, Xuefeng Liu
We describe a strategy of fabricating CO2-triggered oil-in-water Pickering emulsion based on silica nanoparticles functionalized in situ by a trace amount of conventional CO2-switchable surfactant, N-(3-(dimethylamino)propyl)alkyl amide (CnPMA). By alternately bubbling CO2 and N2 at a moderate conditions (30 °C, 80 mL min(-1)), silica nanoparticles reversibly switch between amphipathic and hydrophilic as a result of the adsorption of ammonium (CO2) and the desorption of tertiary amine (N2). The emulsion can then be smart switched "on (stable)" and "off (unstable)", along with homogenization, without needing cooling and heating...
November 15, 2016: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/27777453/development-and-quality-assessment-of-carrageenan-incorporated-low-fat-chevon-patties
#19
N K Nayak, V Pathak
The present study was conducted to develop and assess the quality of carrageenan incorporated chevon patties with the objective of reducing fat content. Efficacy of carrageenan as fat replacers (0.3, 0.6 & 0.9 %) was assessed for development of low fat chevon patties. Emulsion stability and cooking yield increased with the increase in levels of carrageenan. Significantly (P < 0.05) lower fat and cholesterol contents and higher moisture and fat retention were observed in formulation with carrageenan. No significant difference in the mineral content in either of the treatment was recorded...
September 2016: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/27777121/efficacy-of-a-new-topical-cationic-emulsion-of-cyclosporine-a-on-dry%C3%A2-eye-clinical-signs-in-an-experimental-mouse-model-of-dry-eye
#20
Philippe Daull, Laurence Feraille, Stefano Barabino, Nicolas Cimbolini, Sophie Antonelli, Virgine Mauro, Jean-Sébastien Garrigue
Dry eye disease (DED) is a complex, multifactorial pathology characterized by corneal epithelium lesions and inflammation. The aim of the present study was to evaluate the efficacy of a cationic emulsion of cyclosporine A (CsA) in a mouse model that mimics severe dry eye. Eight to 12-week-old female C57BL/6N mice with tail patches of scopolamine were housed in controlled environment chambers to induce dry eye. At day three, following dry eye confirmation by corneal fluorescein staining (CFS, score 0-15) and phenol red thread (PRT) lacrimation test, the mice (n = 10/gp) were either treated 3 times a day in both eyes with drug-free cationic emulsion, a 0...
October 21, 2016: Experimental Eye Research
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