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N-3 emulsion

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https://www.readbyqxmd.com/read/28821102/microencapsulation-of-sardine-oil-application-of-vanillic-acid-grafted-chitosan-as-a-bio-functional-wall-material
#1
K V Vishnu, Niladri S Chatterjee, K K Ajeeshkumar, R G K Lekshmi, C S Tejpal, Suseela Mathew, C N Ravishankar
Vanillic acid grafted chitosan (Va-g-Ch) was evaluated as a new antioxidant wall material for microencapsulation of polyunsaturated fatty acid rich sardine oil. A high grafting ratio of 305mg vanillic acid equivalent/g of polymer was achieved using a free radical mediated grafting reaction. Oil in water emulsion was prepared with an optimised combination of Va-g-Ch and Tween 20 (3.2:1). Sardine oil loaded microparticles (SO-M) were produced (∼75% yield) by spray drying. The average diameter and polydispersity Index (PDI) of the particles were found to be 2...
October 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28816318/a-soluble-star-shaped-silsesquioxane-cored-polymer-towards-novel-stabilization-of-ph-dependent-high-internal-phase-emulsions
#2
Yuxiu Xing, Jun Peng, Kai Xu, Shuxi Gao, Xuefeng Gui, Shengyuan Liang, Longfeng Sun, Mingcai Chen
A well-defined pH-responsive star-shaped polymer containing poly(N,N-dimethylaminoethyl methacrylate) (PDMA) arms and a cage-like methacryloxypropyl silsesquioxane (CMSQ-T10) core was used as an interfacial stabilizer for emulsions consisting of m-xylene and water. We explored the properties of the CMSQ/PDMA star-shaped polymer using the characteristic results of nuclear magnetic resonance (NMR) spectroscopy, size exclusion chromatography (SEC), dynamic light scattering (DLS), and zeta potential and conductivity measurements...
August 17, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28803027/alizarin-yellow-r-ayr-as-compatible-stabilizer-for-miniemulsion-polymerization
#3
Zhang Zhenqian, Susanne Sihler, Ulrich Ziener
HYPOTHESIS: Many solid particles have been used in Pickering stabilized (mini)emulsions. Stabilizing "particles" can be also formed in situ e.g. by aggregation of dye molecules as reported recently. Among the dyes sodium 2-hydroxy-5-[(E)-(4-nitrophenyl)diazenyl]benzoate (Alizarin Yellow R, (AYR)) is one of the best stabilizers. It is assumed to act as sole stabilizer also in heterophase polymerizations and offers a great potential for applications. EXPERIMENTS: Aqueous solutions of AYR in varying concentrations (0...
August 3, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28770315/parameters-for-stable-water-in-oil-lipiodol-emulsion-for-liver-trans-arterial-chemo-eembolization
#4
F Deschamps, L Moine, T Isoardo, L Tselikas, A Paci, L M Mir, N Huang, E Fattal, T de Baère
PURPOSE: Water-in-oil type and stability are important properties for Lipiodol emulsions during conventional trans-arterial chemo-embolization. Our purpose is to evaluate the influence of 3 technical parameters on those properties. MATERIALS AND METHODS: The Lipiodol emulsions have been formulated by repetitive back-and-forth pumping of two 10-ml syringes through a 3-way stopcock. Three parameters were compared: Lipiodol/doxorubicin ratio (2/1 vs. 3/1), doxorubicin concentration (10 vs...
August 2, 2017: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/28767202/effects-of-parenteral-fish-oil-on-plasma-nonesterified-fatty-acids-and-systemic-inflammatory-mediators-in-dogs-following-ovariohysterectomy
#5
Kaoru Tsuruta, Robert C Backus, Amy E DeClue, Kevin L Fritsche, Fred A Mann
OBJECTIVE: To evaluate the effects of intravenous (IV) infusion of fish oil (FO) emulsion following ovariohysterectomy (OVH) on inflammatory mediators and plasma omega-3 nonesterified fatty acids (NEFA) concentrations in dogs. DESIGN: Prospective clinical study. SETTING: University teaching hospital. ANIMALS: Twenty-nine privately owned dogs undergoing routine OVH. INTERVENTIONS: Postoperative 3-hour IV infusion of saline (n = 9), FO (Omegaven, n = 10), or soybean oil (SO, intralipid, n = 10) emulsion and blood collected before, 5 and 24 hours following OVH for plasma NEFA and RBC membrane fatty acids (FAs) concentrations, leukocyte cytokine production capacity, and C-reactive protein (CRP) measurement...
August 2, 2017: Journal of Veterinary Emergency and Critical Care
https://www.readbyqxmd.com/read/28741857/surface-cross-linked-ultra-high-molecular-weight-polyethylene-by-emulsified-diffusion-of-dicumyl-peroxide
#6
Sanem Kayandan, Brinda N Doshi, Ebru Oral, Orhun K Muratoglu
Cross-linking improves the wear resistance of ultrahigh molecular weight polyethylene (UHMWPE) used in hip and knee implants. Free radicals, generated by ionizing radiation or chemically, react to form cross-links. Limiting cross-linking to the articulating surface of the implant is desirable to enable high wear resistance on the surface and higher strength and toughness in the bulk. We investigated the diffusion of emulsified dicumyl peroxide (DCP) into vitamin E-blended UHMWPE (0.1 and 0.3 wt. % vitamin-E) with subsequent thermal decomposition in situ to obtain surface cross-linking with the objective of achieving surface wear rate equivalent or lower than that of current clinically available materials...
July 25, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28740349/functional-lipidomics-in-patients-on-home-parenteral-nutrition-effect-of-lipid-emulsions
#7
Loris Pironi, Mariacristina Guidetti, Ornella Verrastro, Claudia Iacona, Federica Agostini, Caterina Pazzeschi, Anna Simona Sasdelli, Michele Melchiorre, Carla Ferreri
AIM: To investigate the fatty acid-based functional lipidomics of patients on long-term home parenteral nutrition receiving different intravenous lipid emulsions. METHODS: A cross-sectional comparative study was carried out on 3 groups of adults on home parenteral nutrition (HPN), receiving an HPN admixture containing an olive-soybean oil-based intravenous lipid emulsion (IVLE) (OO-IVLE; n = 15), a soybean- medium-chain triacylglycerol-olive-fish oil-based IVLE (SMOF-IVLE; n = 8) or HPN without IVLE (No-IVLE; n = 8) and 42 healthy controls (HCs)...
July 7, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28738225/the-effect-of-low-fat-beef-patties-formulated-with-a-low-energy-fat-analogue-enriched-in-long-chain-polyunsaturated-fatty-acids-on-lipid-oxidation-and-sensory-attributes
#8
Marta Alejandre, Denis Passarini, Iciar Astiasarán, Diana Ansorena
A new low-energy gelled emulsion containing algae oil was developed as animal fat replacer. Its stability was evaluated under different storage conditions: 4V (4°C/vacuum), 4NV (4°C/no vacuum), 25V (25°C/vacuum) and 25NV (25°C/no vacuum). According to moisture, hardness, color and lipid oxidation data, 4°C under vacuum (4V) was selected as the best condition. Once the gelled emulsion was characterized, its effectiveness as fat analogue was demonstrated in beef patties. Reformulated patties were produced with 100% of animal fat replacement and compared to conventional patties (9%fat)...
July 13, 2017: Meat Science
https://www.readbyqxmd.com/read/28720933/bioaccessibility-of-hydroxytyrosol-and-n-3-fatty-acids-as-affected-by-the-delivery-system-simple-double-and-gelled-double-emulsions
#9
Susana Cofrades, Ricard Bou, Linda Flaiz, Alba Garcimartín, Juana Benedí, Raquel Mateos, Francisco J Sánchez-Muniz, Raúl Olivero-David, Francisco Jiménez-Colmenero
This study examines the influence of different food-grade n-3 PUFA-enriched simple emulsion (SE), double emulsion (DE) and gelled double emulsion (GDE) delivery systems on the extent of lipolysis, antioxidant capacity and the bioaccessibility of hydroxytyrosol (HTy). GDE emulsion offered better protection for HTy (89%) than the other systems (79% in SE and DE). The reducing capacity of the emulsions containing HTy were not altered during oral digestion. However, "in vitro" gastric and intestinal phases significantly reduced the antioxidant activity of all systems...
June 2017: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/28720931/quality-attributes-of-dahi-prepared-from-milk-fortified-with-omega-3-fatty-acids-phytosterols-and-polydetxrose
#10
N Veena, B Surendra Nath, Bandla Srinivas, B V Balasubramanyam
In the present study, dahi prepared using milk fortified with omega-3 fatty acids (flaxseed oil), phytosterols and soluble fibre (polydextrose) through an oil-in-water emulsion was evaluated for the physico-chemical and sensory quality. The levels of fortificants in fortified dahi were also estimated. Fortification process did not affect the degree of fermentation in terms of pH and acidity. Sensory scores of fortified and control dahi did not differ significantly. Fortified dahi had lower viscosity, firmness and consistency, and higher water holding capacity (WHC) compared to control; however, significant differences were not observed in firmness and consistency values...
June 2017: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/28717975/development-of-a-novel-polymeric-nanocomposite-complex-for-drugs-with-low-bioavailability
#11
Mduduzi N Sithole, Yahya E Choonara, Lisa C du Toit, Pradeep Kumar, Thashree Marimuthu, Pierre P D Kondiah, Viness Pillay
Semi-synthetic biopolymer complex (SSBC) nanoparticles were investigated as a potential oral drug delivery system to enhance the bioavailability of a poorly water-soluble model drug acyclovir (ACV). The SSBCs were prepared from cross-linking of hydroxyl groups on hyaluronic acid (HA) with poly(acrylic acid) (PAA) resulting in ether linkages. Thereafter, conjugation of 2-hydroxypropyl-β-cyclodextrin (HP-β-CD) onto HA-PAA was accomplished using a 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC)/N-hydroxysuccinimide (NHS)-promoted coupling reaction...
July 17, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/28707367/colloidal-synthesis-of-silicon-carbon-composite-materials-for-lithium-ion-batteries
#12
Haiping Su, Alejandro A Barragan, Linxiao Geng, Donghui Long, Licheng Ling, Krassimir N Bozhilov, Lorenzo Mangolini, Juchen Guo
We report colloidal routes to synthesize silicon@carbon composites for the first time. Surface-functionalized Si nanoparticles (SiNPs) dissolved in styrene and hexadecane are used as the dispersed phase in oil-in-water emulsions, from which yolk-shell and dual-shell hollow SiNPs@C composites are produced via polymerization and subsequent carbonization. As anode materials for Li-ion batteries, the SiNPs@C composites demonstrate excellent cycling stability and rate performance, which is ascribed to the uniform distribution of SiNPs within the carbon hosts...
July 14, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28699164/novel-amino-acid-based-surfactant-for-silicone-emulsification-and-its-application-in-hair-care-products-a-promising-alternative-to-quaternary-ammonium-cationic-surfactants
#13
Mika Fujii, Motoki Inoue, Toshiro Fukami
OBJECTIVE: Quaternary ammonium cationic surfactants (ACSs) and N-[3-alkyl(12,14)oxy-2-hydroxypropyl]-L-arginine hydrochloride (N-AOHPA) were used to emulsify silicone. The potential of the resulting emulsions in hair conditioning products was investigated. METHODS: The emulsions were prepared using a homogenizer and/or high-pressure homogenizer. ACSs and N-AOHPA were used as silicone emulsifiers. The stability of the emulsions were evaluated by measuring particle sizes, creaming fractions, polydispersity indexes and zeta potentials...
July 12, 2017: International Journal of Cosmetic Science
https://www.readbyqxmd.com/read/28685297/hemodynamic-effects-of-lipid-based-oxygen-microbubbles-via-rapid-intravenous-injection-in-rodents
#14
Katherine J Black, Andrew T Lock, Lindsay M Thomson, Alexis R Cole, Xiaoqi Tang, Brian D Polizzotti, John N Kheir
PURPOSE: Low oxygen levels, or hypoxemia, is a common cause of morbidity and mortality in critically ill patients. Hypoxemia is typically addressed by increasing the fraction of inspired oxygen, the use of mechanical ventilation, or more invasive measures. Recently, the injection of oxygen gas directly into the bloodstream by packaging it within lipid-based oxygen microbubbles (LOMs) has been explored. The purpose of this work is to examine the acute hemodynamic effects of intravenous injections of LOMs...
July 6, 2017: Pharmaceutical Research
https://www.readbyqxmd.com/read/28662951/cd11a-and-cd49d-enhance-the-detection-of-antigen-specific-t-cells-following-human-vaccination
#15
Allison F Christiaansen, Upasna Gaur Dixit, Rhea N Coler, Anna Marie Beckmann, Steven G Reed, Patricia L Winokur, M Bridget Zimmerman, Steven M Varga, Mary E Wilson
BACKGROUND: Determining the efficacy of human vaccines that induce antigen-specific protective CD4 T cell responses against pathogens can be particularly challenging to evaluate. Surface expression of CD11a and CD49d has been shown to identify antigen-specific CD4 T cells against viral pathogens in mice. We hypothesized that CD11a and CD49d would also serve as markers of human antigen-specific T cells responding to vaccination. METHODS: A phase I vaccine trial enabled us to evaluate a novel gating strategy based on surface expression of CD11a and CD49d as a means of detecting antigen-specific, cytokine producing CD4 and CD8 T cells induced after vaccination of naïve individuals against leishmaniasis...
July 24, 2017: Vaccine
https://www.readbyqxmd.com/read/28662102/a-novel-monoclonal-antibody-against-the-n-terminus-of-a%C3%AE-1-42-reduces-plaques-and-improves-cognition-in-a-mouse-model-of-alzheimer-s-disease
#16
Hai-Yan Xing, Bin Li, Dan Peng, Chun-Yan Wang, Guan-Ying Wang, Pan Li, Ying-Ying Le, Ji-Ming Wang, George Ye, Jian-Hong Chen
Senile plaques consisting of Amyloid-beta (Aβ) peptides, in particular Aβ1-42, are the hallmark of Alzheimer's disease (AD) and have been the primary therapeutic targets. Passive immunotherapy with monoclonal antibodies (mAbs) has shown initial success in mouse models of AD. However, the existing Aβ-directed mAbs mostly were tested on animal models or patients with advanced disease. The effects and mechanisms of mAbs on animals or human trial participants in the prodromal phase of AD are not fully clarified...
2017: PloS One
https://www.readbyqxmd.com/read/28641075/postconditioning-with-intralipid-emulsion-protects-against-reperfusion-injury-in-post-infarct-remodeled-rat-hearts-by-activation-of-ros-akt-erk-signaling
#17
Michael Zaugg, Phing-How Lou, Eliana Lucchinetti, Manoj Gandhi, Alexander S Clanachan
The clinically used lipid emulsion Intralipid (ILE) reduces ischemia reperfusion injury in healthy rodent hearts. We tested whether ILE is cardioprotective in postinfarct remodeled hearts. Post-infarct remodeled and sham Sprague-Dawley rat hearts were perfused in working mode and subjected to ischemia (15 minutes) and reperfusion (30 minutes). Left ventricular (LV) work was measured in hearts that were untreated or that received ILE (1%) postconditioning administered at the onset of reperfusion, or the reactive oxygen species (ROS) scavenger N-(2-mercaptopropionyl)-glycine (10 μM) alone or in combination with ILE...
June 1, 2017: Translational Research: the Journal of Laboratory and Clinical Medicine
https://www.readbyqxmd.com/read/28634838/superselective-transarterial-chemoembolization-as-an-alternative-to-surgery-in-symptomatic-enlarging-liver-hemangiomas
#18
İlgin Özden, Arzu Poyanlı, Yılmaz Önal, Ali Aslan Demir, Gültekin Hoş, Bülent Acunaş
BACKGROUND: Transarterial embolization of liver hemangiomas has not been considered to be consistently effective. METHODS: The charts of 25 patients who underwent superselective transarterial chemoembolization with the bleomycin-lipiodol emulsion were evaluated retrospectively. RESULTS: Twenty-two patients had abdominal pain; asymptomatic/vaguely symptomatic enlargement was the treatment indication in three patients. A single session was conducted in 17 patients, two sessions in 7 and three sessions in one...
June 20, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28634213/omega-3-fatty-acids-increase-the-unfolded-protein-response-and-improve-amyloid-%C3%AE-phagocytosis-by-macrophages-of-patients-with-mild-cognitive-impairment
#19
Henry M Olivera-Perez, Larry Lam, Johnny Dang, Weilan Jiang, Fabian Rodriguez, Elizabeth Rigali, Sarah Weitzman, Verna Porter, Liudmilla Rubi, Marco Morselli, Matteo Pellegrini, Milan Fiala
Mϕs of patients with Alzheimer's disease and mild cognitive impairment (MCI) are defective in amyloid-β1-42 (Aβ) phagocytosis and have low resistance to apoptosis by Aβ. ω-3 in vitro and in vivo and the ω-3 mediator, resolvin D1, in vitro increase Aβ phagocytosis by Mϕs of patients with MCI. We have investigated the unfolded protein response (UPR) to endoplasmic reticulum (ER) stress by Mϕs in a longitudinal study of fish-derived, ω-3-supplemented patients with MCI. Patients in the apolipoprotein E (ApoE)e3/e3 subgroup over time exhibited an increase of protein kinase RNA-like ER kinase (PERK) expression, Aβ phagocytosis, intermediate M1-M2 Mϕ type, and a Mini-Mental State Examination (MMSE) rate of change of +1...
June 20, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28628490/comparison-of-efficacy-of-difluprednate-0-05-and-loteprednol-gel-0-5-after-cataract-surgery
#20
Bryan Abessi, Lauren Brooksby, Robert L Schultze
PURPOSE: To compare the outcomes and complications of topical difluprednate 0.05% and loteprednol gel 0.5% after routine cataract surgery. METHODS: Subjects received either difluprednate emulsion 0.05% (n=30 eyes) or loteprednol gel 0.5% (n=30 eyes) after routine cataract surgery. Topical steroid drops were initiated 3 days before cataract surgery and continued for 2 weeks postoperatively. Anterior chamber (AC) cell grade, corneal edema, corneal pachymetry, visual acuity, ocular surface quality (Oxford scale), and intraocular pressure (IOP) were evaluated at 1 day, 1 week, and 1 month postoperatively...
June 16, 2017: Eye & Contact Lens
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