keyword
https://read.qxmd.com/read/38537234/clinical-and-urodynamics-outcomes-in-pediatric-primary-bladder-diverticula-a-comparative-study
#1
JOURNAL ARTICLE
Birgül Karaaslan, Mehmet O Kuzdan
OBJECTIVE: This study aimed to compare the effects of bladder diverticula smaller than 30 (SD) mm and larger than 30 mm (LD) on bladder functions and urodynamics. MATERIALS AND METHODS: Our retrospective analysis involved a cohort of 40 pediatric patients diagnosed with primary bladder diverticula. RESULTS: The predicted mean bladder capacity (MBC) was 197.7 ± 95.8 mL, whereas the observed MBC was lower at an average of 170.1 ± 79...
2024: Cirugia y Cirujanos
https://read.qxmd.com/read/38537158/impact-of-broadening-trial-eligibility-criteria-on-the-inclusion-of-patients-with-brain-metastases-in-cancer-clinical-trials-time-series-analyses-for-2012-2022
#2
JOURNAL ARTICLE
Hong Xiao, Riha Vaidya, Dawn L Hershman, Joseph M Unger
PURPOSE: In October 2017, an ASCO, Friends of Cancer Research (FoCR), and US Food and Drug Administration (ASCO/FoCR/FDA) task force recommended that common eligibility criteria be modified to make trials more inclusive. We examined whether patterns of exclusions regarding patients with brain metastases changed over time in relation to these recommendations. METHODS: Trial eligibility criteria were abstracted from ClinicalTrials.gov for phase I-III US-based interventional clinical trials for patients with advanced breast, colorectal, lung, or melanoma cancers from January 2012 to December 2022...
March 27, 2024: Journal of Clinical Oncology
https://read.qxmd.com/read/38537067/conventional-epithelial-off-corneal-crosslinking-in-patients-with-progressive-keratoconus-10-year-outcomes
#3
JOURNAL ARTICLE
Jérémy Bordais, Myriam Cassagne, David Touboul, Valentine Saunier, Jacqueline Butterworth, François Malecaze, Vincent Soler, Pierre Fournié
PURPOSE: Corneal crosslinking (CXL) is the standard treatment of progressive keratoconus (KC). We evaluated the safety and 10-year outcomes of conventional "epithelial-off" CXL for progressive KC for the first time in a cohort in France. METHODS: We conducted a retrospective review of patients undergoing conventional CXL (Dresden protocol) in our tertiary ophthalmology department from 2006 to 2011 with 10-year follow-up. The primary outcome was change in preoperative versus postoperative keratometry measured by maximum keratometry (Kmax), steep keratometry (K2), flat keratometry (K1), mean keratometry (Km), and topographic cylinder...
March 27, 2024: Cornea
https://read.qxmd.com/read/38537030/longitudinal-bond-strength-of-a-universal-adhesive-and-chemical-dentin-characterization-under-different-acid-etching-protocols
#4
JOURNAL ARTICLE
Lucélia Lemes Gonçalves, Anuradha Prakki, Tânia Mara da Silva, Arwa Bafail, Janaína Bortolatto, Alexander Terry Stavroullakis, Sérgio Eduardo de Paiva Gonçalves
OBJECTIVE: This study aimed to analyze the longitudinal bond strength of a universal adhesive and chemically characterize the dentin substrate under different acid etching protocols. METHODOLOGY: Dentin samples were etched with polyacrylic acid 25% (PAA) for 10 seconds (n=3) and phosphoric acid 32% (PA) for 15 seconds (n=3) and analyzed by Fourier transform infrared spectroscopy - attenuated total reflectance (FTIR-ATR) before and after treatment. For collagen degradation, samples (n=12) were divided into 3 groups: PAA, PA, and Deionized water (control), and analyzed by the quantity of solubilized type I collagen C-terminal cross-linked telopeptides and solubilized C-terminal peptide in relation to total protein concentration (ICTPtp and CTXtp) and by their ultimate tensile strength (UTS)...
2024: Journal of Applied Oral Science: Revista FOB
https://read.qxmd.com/read/38536214/health-behavior-change-intervention-preferences-expressed-by-american-indian-cancer-survivors-from-a-southwest-tribal-community-semistructured-interview-study
#5
JOURNAL ARTICLE
Jennifer Erdrich, Felina M Cordova-Marks, William O Carson, Jennifer W Bea, William R Montfort, Cynthia A Thomson
BACKGROUND: While many factors, including social determinants of health, affect cancer mortality, one modifiable risk factor that may contribute to cancer disparities is obesity. The prevalence of obesity in the American Indian/Alaska Native population is 48.1% per the Centers for Disease Control and Prevention. The overall cancer mortality for the American Indian/Alaska Native population is 18% higher than the White population as reported by the American Cancer Society. Interventions tailored to American Indian/Alaska Native communities that promote healthy lifestyle behaviors after cancer diagnosis and prior to cancer surgery (prehab) might improve cancer outcomes for this population...
March 27, 2024: JMIR Formative Research
https://read.qxmd.com/read/38536103/hospital-inpatient-nutrition-service-errors-and-patient-safety-interventions-a-scoping-review
#6
JOURNAL ARTICLE
Davis Austria, Chelsea McConnell, Charlene Pope
OBJECTIVES: Food service errors are prevalent in healthcare hospital inpatient settings. Like medication administration errors, these mistakes can result in disastrous consequences. This scoping review aimed to identify the evidence describing hospitals' nutrition department service errors and subsequent patient safety interventions. METHODS: The review was conducted on four electronic databases, OVID MedlinePlus, PubMed, Scopus, and CINAHL, to search for articles reporting hospital food-related errors...
March 28, 2024: Journal of Patient Safety
https://read.qxmd.com/read/38536042/genetic-variation-in-severe-cystic-fibrosis-liver-disease-is-associated-with-novel-mechanisms-for-disease-pathogenesis
#7
JOURNAL ARTICLE
Jaclyn R Stonebraker, Rhonda G Pace, Paul J Gallins, Hong Dang, Melis A Aksit, Anna V Faino, William W Gordon, Sonya MacParland, Michael J Bamshad, Ronald L Gibson, Garry R Cutting, Peter R Durie, Fred A Wright, Yi-Hui Zhou, Scott M Blackman, Wanda K O'Neal, Simon C Ling, Michael R Knowles
BACKGROUND AND AIMS: It is not known why severe cystic fibrosis (CF) liver disease (CFLD) with portal hypertension occurs in only ~7% of people with CF (pwCF). We aimed to identify genetic modifiers for severe CFLD to improve understanding of disease mechanisms. APPROACH AND RESULTS: Whole genome sequencing was available in 4,082 pwCF with pancreatic insufficiency (n=516 with severe CFLD; n=3,566 without CFLD). We tested ~15.9 million SNPs for association with severe CFLD versus no-CFLD, using pre-modulator clinical phenotypes including: 1) genetic variant (SERPINA1; Z-allele) previously associated with severe CFLD; 2) candidate SNPs (n=205) associated with non-CF liver diseases; 3) genome-wide association study (GWAS) of common/rare SNPs; 4) transcriptome-wide association (TWAS); and 5) gene-level and pathway analyses...
March 27, 2024: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://read.qxmd.com/read/38535440/a-standardized-extract-of-microalgae-phaeodactylum-tricornutum-mi136-inhibit-d-gal-induced-cognitive-dysfunction-in-mice
#8
JOURNAL ARTICLE
Jonathan Maury, Antoine Delbrut, Vanessa Villard, Rémi Pradelles
The microalgae Phaeodactylum tricornutum (PT) is distinguished by its rich nutrient profile, characterized by well-documented neuroprotective activities, including fucoxanthin (FX), a major carotenoid and polyunsaturated omega-3 fatty acids (n-3 PUFA). The current study aims to evaluate the protective effects of a standardized extract of PT (Mi136) containing 2% FX on cognitive function, oxidative stress, and inflammation parameters in a mouse model of accelerated aging. Seventy-two (72) male mice were randomly assigned to the blank control group (BC), negative control group (NC), and four similar microalgae extract of PT groups (branded as BrainPhyt™) with different human equivalent doses to evaluate potential dose-response effects...
February 21, 2024: Marine Drugs
https://read.qxmd.com/read/38535359/fatty-acid-profile-and-escherichia-coli-and-salmonella-sp-load-of-wild-caught-seaweed-fly-fucellia-maritima-haliday-1838-diptera-anthomyiidae
#9
JOURNAL ARTICLE
Felipe Lourenço, Ricardo Calado, Marisa Pinho, Maria Rosário Domingues, Isabel Medina, Olga M C C Ameixa
World aquaculture is expected to continue to grow over the next few decades, which amplifies the need for a higher production of sustainable feed ingredients for aquatic animals. Insects are considered good candidates for aquafeed ingredients because of their ability to convert food waste into highly nutritional biomass. However, commercially available terrestrial insect species lack n-3 long-chain polyunsaturated fatty acids (LC-PUFAs), which are essential biomolecules for marine cultured species. Nevertheless, several coastal insect species feature LC-PUFAs in their natural fatty acid (FA) profile...
February 28, 2024: Insects
https://read.qxmd.com/read/38535325/the-effect-of-dietary-protein-hydrolysate-from-black-soldier-fly-larvae-and-schizochytrium-on-palatability-nutrient-metabolites-and-health-status-in-beagle-dogs
#10
JOURNAL ARTICLE
Yu Wei, Lingfeng Xue, Deying Ma, Yuxiao Weng, Mingkang Liu, Luyang Li, Ziyi Dai, Ziyun Zhao, Haifeng Wang, Xiao Xu
Protein hydrolysate from black soldier fly larvae (BSFP) has garnered great attention with its lower allergenicity, high amount of essential amino acids, and small bioactive peptides. Schizochytrium is a promising alternative source of n-3 FUFA because it has enriched docosahexaenoic acid (DHA, C22: 6). The aim of this study was to assess palatability, the presence of diarrhea, plasma biochemistry panels, anti-oxidative and anti-inflammatory effects, and immune function in beagle dogs when supplementing a mixture of protein hydrolysate from black soldier fly larvae and schizochytrium (BSFPs) into their diets...
March 14, 2024: Metabolites
https://read.qxmd.com/read/38535161/-show-me-what-you-got-the-nomological-network-of-the-ability-to-pose-facial-emotion-expressions
#11
JOURNAL ARTICLE
Mattis Geiger, Sally Gayle Olderbak, Oliver Wilhelm
Just as receptive emotional abilities, productive emotional abilities are essential for social communication. Although individual differences in receptive emotional abilities, such as perceiving and recognizing emotions, are well-investigated, individual differences in productive emotional abilities, such as the ability to express emotions in the face, are largely neglected. Consequently, little is known about how emotion expression abilities fit in a nomological network of related abilities and typical behavior...
February 26, 2024: Journal of Intelligence
https://read.qxmd.com/read/38534773/-n-3-methylbutyl-benzisoselenazol-3-2h-one-exerts-antifungal-activity-in-vitro-and-in-a-mouse-model-of-vulvovaginal-candidiasis
#12
JOURNAL ARTICLE
Xiuyi Liang, Agata J Pacuła-Miszewska, Richa Vartak, Milankumar Prajapati, Haiyan Zheng, Caifeng Zhao, Ganming Mao, Ketankumar Patel, Natalya U Fedosova, Jacek Ścianowski, Blase Billack
In the present work, we evaluated the antifungal activities of two novel ebselen analogs, N -allyl-benzisoselenazol-3(2H)-one ( N -allyl-bs) and N -3-methylbutylbenzisoselenazol-3(2H)-one ( N -3mb-bs). Colorimetric and turbidity assays were performed to determine the minimum inhibitory concentration (MIC) of these compounds in S1 (fluconazole-sensitive) and S2 (fluconazole-resistant) strains of C. albicans . N -3mb-bs was more active than the N -allyl-bs compound. It is noteworthy that the concentration of N -3mb-bs observed to inhibit fungal growth by 50% (18...
March 14, 2024: Current Issues in Molecular Biology
https://read.qxmd.com/read/38534518/regeneration-process-of-an-autologous-tissue-engineered-trachea-atet-in-a-rat-patch-tracheoplasty-model
#13
JOURNAL ARTICLE
Shun Iwasaki, Koichi Deguchi, Ryosuke Iwai, Yasuhide Nakayama, Hiroomi Okuyama
The treatment of long-tracheal lesion is difficult because there are currently no viable grafts for tracheal replacement. To solve this problem, we have developed an autologous Tissue-Engineered Trachea (aTET), which is made up of collagenous tissues and cartilage-like structures derived from rat chondrocytes. This graft induced successful long-term survival in a small-animal experiment in our previous study. In this study, we investigated the regeneration process of an aTET to attain reproducible success. We prepared an aTET by using a specially designed mold and performed patch tracheoplasty with an aTET...
February 29, 2024: Bioengineering
https://read.qxmd.com/read/38534280/screening-for-high-risk-human-papillomavirus-reveals-hpv52-and-hpv58-among-pediatric-and-adult-patient-saliva-samples
#14
JOURNAL ARTICLE
Hunter Hinton, Lorena Herrera, Sofia Valenzuela, Katherine M Howard, Karl Kingsley
Previous research has demonstrated that the human papillomavirus (HPV) can infect a wide range of human tissues, including those within the oral cavity. High-risk oral HPV strains have been associated with the development and progression of oral cancers, including oral squamous cell carcinomas. Although many studies have examined the prevalence of the high-risk strains HPV16 and HPV18, far fewer have assessed the prevalence of other high-risk HPV strains. An approved study protocol was used to identify HPV52 and HPV58 among clinical samples ( n = 87) from a saliva biorepository...
February 29, 2024: Dentistry Journal
https://read.qxmd.com/read/38532630/restoration-of-t-and-b-cell-generation-in-x-linked-severe-combined-immunodeficiency-mice-through-adenine-base-editing-of-hematopoietic-stem-cells
#15
JOURNAL ARTICLE
Lu Zhang, Kai Li, Zhiwei Liu, Lisha An, Haikun Wei, Shanshan Pang, Zongfu Cao, Xingxu Huang, Xiaohua Jin, Xu Ma
Base editing of hematopoietic stem/progenitor cells (HSPCs) is an attractive strategy for treating immunohematologic diseases. However, the feasibility of using adenine base-edited HSPCs for treating X-linked severe combined immunodeficiency (SCID-X1), the influence of dose-response relationships on immune cell generation, and the potential risks have not been demonstrated in vivo. Here, a humanized SCID-X1 mouse model was established and 86.67% ± 2.52% (n = 3) of mouse hematopoietic stem cell (HSC) pathogenic mutations were corrected, with no sgRNA-dependent off-target effects detected...
March 26, 2024: Molecular Therapy
https://read.qxmd.com/read/38532328/tools-to-measure-barriers-to-medication-management-capacity-in-older-adults-a-scoping-review
#16
JOURNAL ARTICLE
Bincy Baby, Annette McKinnon, Kirk Patterson, Hawa Patel, Rishabh Sharma, Caitlin Carter, Ryan Griffin, Catherine Burns, Feng Chang, Sara Jt Guilcher, Linda Lee, Sara Abu Fadaleh, Tejal Patel
BACKGROUND: Medication management capacity is a crucial component of medication adherence, particularly among older adults. Various factors, including physical abilities, cognitive functions, sensory capabilities, motivational, and environmental factors, influence older adults' ability to manage medications. It is, therefore, crucial to identify appropriate tools that allow clinicians to determine which factors may impact medication management capacity and, consequently, nonadherence to medications...
March 27, 2024: BMC Geriatrics
https://read.qxmd.com/read/38532298/mobile-apps-for-common-noncommunicable-disease-management-systematic-search-in-app-stores-and-evaluation-using-the-mobile-app-rating-scale
#17
JOURNAL ARTICLE
Khang Jin Cheah, Zahara Abdul Manaf, Arimi Fitri Mat Ludin, Nurul Huda Razalli, Norfilza Mohd Mokhtar, Sawal Hamid Md Ali
BACKGROUND: The success of mobile apps in improving the lifestyle of patients with noncommunicable diseases through self-management interventions is contingent upon the emerging growth in this field. While users of mobile health (mHealth) apps continue to grow in number, little is known about the quality of available apps that provide self-management for common noncommunicable diseases such as diabetes, hypertension, and obesity. OBJECTIVE: We aimed to investigate the availability, characteristics, and quality of mHealth apps for common noncommunicable disease health management that included dietary aspects (based on the developer's description), as well as their features for promoting health outcomes and self-monitoring...
March 12, 2024: JMIR MHealth and UHealth
https://read.qxmd.com/read/38532151/electroacupuncture-promotes-angiogenesis-in-mice-with-cerebral-ischemia-by-inhibiting-mir-7
#18
JOURNAL ARTICLE
Qian Yu, Shi Shu, Xin-Yao Ju, Wei Peng, Xue-Qi Ren, Shu-Han Si, Shi-Zhen Song, Xue-Yun Xie, Bang-Jiang Fang, Shuang Zhou
OBJECTIVE: To observe the angiogenesis effect of electroacupuncture (EA) at Shuigou acupoint (GV 26) in the treatment of cerebral ischemia, and explore the value of miRNA-7 (miR-7) in it. METHODS: First, 48 mice were randomly divided into sham operation, middle cerebral artery occlusion (MCAO) model, and EA treatment groups. Then 9 mice were divided into carrier control group, miR-7 knockout group and miR-7 overexpression group (n=3 each group). Finally, 20 mice were divided into model and carrier control group, model and miR-7 knockout group, EA treatment and carrier control group and EA treatment and miR-7 overexpression group, with 3-6 mice in each group...
March 27, 2024: Chinese Journal of Integrative Medicine
https://read.qxmd.com/read/38530989/unraveling-the-activity-and-mechanism-of-tm-g-c-4-n-3-electrocatalysts-in-the-oxygen-reduction-reaction
#19
JOURNAL ARTICLE
Hao Deng, Dan Deng, Shang-Bin Jin, Zhihong Tian, Li-Ming Yang
In this work, a high-throughput screening strategy and density functional theory (DFT) are jointly employed to identify high-performance TM@g-C4 N3 (TM = 3d, 4d, 5d transition metals) single-atom catalysts (SACs) for the oxygen reduction reaction (ORR). Comprehensive studies demonstrated that Cu@, Zn@, and Ag@g-C4 N3 show high ORR catalytic activities under both acidic and alkaline conditions with favorable overpotentials (ηORR ) of 0.70, 0.89, and 0.89 V, respectively; among them, Cu@g-C4 N3 is the best candidate...
March 26, 2024: ACS Applied Materials & Interfaces
https://read.qxmd.com/read/38530281/enhancing-oncolytic-virus-efficiency-with-methionine-and-n-3-aminoprolil-methacrylamide-modified-acrylamide-cationic-block-polymer
#20
JOURNAL ARTICLE
Gong Chen, Yuan Yuan, Ying Li, Qianyuan He, Zizhen Qin, Han Hu, Congcong Gao, Zushun Xu, Qi Xu, Qinglei Gao, Fei Li
Oncolytic virus ablation of tumor cells has the advantages of high tumor selectivity, strong immunogenicity, and low side effects. However, the recognition and clearance of oncolytic viruses by the immune system are the main factors limiting their anti-tumor efficiency. As a highly biosafe and highly modifiable oncolytic virus vector, acrylamide can improve the long-term circulation of oncolytic viruses. Still, it is limited in its uptake efficiency by tumor cells. Herein, we constructed an N -hydroxymethyl acrylamide- b -( N -3-aminopropyl methacrylamide)- b -DMC block copolymer (NMA- b -APMA- b -DMA, NAD) as an oncolytic virus carrier, which not only improves the long-term circulation of oncolytic viruses in the body but also shows excellent stability for loading an oncolytic virus...
March 26, 2024: Journal of Materials Chemistry. B, Materials for Biology and Medicine
keyword
keyword
120752
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.