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https://www.readbyqxmd.com/read/29149720/a-robust-strategy-for-preparation-of-sequential-stimuli-responsive-block-copolymer-prodrugs-via-thiolactone-chemistry-to-overcome-multiple-anticancer-drug-delivery-barriers
#1
Wendong Ke, Wei Yin, Zengshi Zha, Jean Felix Mukerabigwi, Weijian Chen, Yuheng Wang, Chuanxin He, Zhishen Ge
Block copolymer prodrugs (BCPs) have attracted considerable attentions in clinical translation of nanomedicine owing to their self-assembly into well-defined core-shell nanoparticles for improved pharmacokinetics, stability in blood circulation without drug leakage, and optimized biodistribution. However, a cascade of physiological barriers against specific delivery of drugs into tumor cells limit the final therapeutic efficacy. Herein, we report a robust and facile strategy based on thiolactone chemistry to fabricate well-defined BCPs with sequential tumor pH-promoted cellular internalization and intracellular stimuli-responsive drug release...
November 9, 2017: Biomaterials
https://www.readbyqxmd.com/read/29149647/dietary-fish-oil-differentially-ameliorates-high-fructose-diet-induced-hepatic-steatosis-and-hyperlipidemia-in-mice-depending-on-time-of-feeding
#2
Katsutaka Oishi, Tatsuya Konishi, Chiaki Hashimoto, Saori Yamamoto, Yoshinori Takahashi, Yasuhiko Shiina
Chrononutrition is the science of nutrition based on chronobiology. Numerous epidemiological studies have shown that fish oil (FO) reduces the risk of cardiovascular events through various actions such as lowering triglycerides. The present study aimed to determine the time of day when the hypertriglyceridemia-decreasing ability of FO is optimal in mice. A high-fructose diet (HFrD) that induces hyperlipidemia in mice was replaced with the same diet containing 4% FO (HFrD-4% FO) at different times of the day for 2 weeks as described below...
October 12, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29149483/factors-influencing-the-quality-of-vital-signs-data-in-electronic-health-records-a-qualitative-study
#3
Jean E Stevenson, Johan Israelsson, Goran Petersson, Peter A Bath
AIMS AND OBJECTIVES: The purpose of this study was to investigate reasons for inadequate documentation of vital signs in an electronic health record. BACKGROUND: Monitoring vital signs is crucial to detecting and responding to patient deterioration. The ways in which vital signs are documented in electronic health records have received limited attention in the research literature. A previous study revealed that vital signs in an electronic health record were incomplete and inconsistent...
November 17, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/29149427/the-impact-of-the-national-bowel-screening-program-in-the-netherlands-on-detection-and-treatment-of-endoscopically-unresectable-benign-polyps
#4
C C M Marres, C J Buskens, E Schriever, P C M Verbeek, M W Mundt, W A Bemelman, A W H van de Ven
BACKGROUND: In January 2014, a national bowel cancer screening program started in the Netherlands. The program is being implemented in phases until 2019. Due to this program, an increase in patients referred for a colorectal resection for benign, but endoscopically unresectable polyps, is expected. So far, most resections are performed according to oncological principles despite no pre-operative histological diagnosis of malignancy. The aim of this study was to analyze the increase in referred patients during the first year of the screening program and to compare pathological results and clinical outcome of resections of patients undergoing resection for benign polyps before and after implementation of screening...
November 17, 2017: Techniques in Coloproctology
https://www.readbyqxmd.com/read/29149142/mapping-the-association-between-vitamin-d-and-low-back-pain-a-systematic-review-and-meta-analysis-of-observational-studies
#5
Joshua Zadro, Debra Shirley, Manuela Ferreira, Ana Paula Carvalho-Silva, Sarah E Lamb, Cyrus Cooper, Paulo H Ferreira
BACKGROUND: Low back pain (LBP) is the highest contributor to disability worldwide, with current intervention strategies only providing small to moderate analgesic effects. The use of vitamin D supplementation for LBP has gained interest due to its proposed anti-inflammatory and neuromodulatory properties. However, it is still unclear whether vitamin D levels differ between those with and without LBP or if vitamin D levels are associated with pain intensity. OBJECTIVES: We aim to investigate the association between vitamin D levels and LBP and to determine if vitamin D levels correlate with pain intensity in individuals with LBP...
November 2017: Pain Physician
https://www.readbyqxmd.com/read/29148763/discovery-of-n-3-carbamoyl-5-5-7-7-tetramethyl-5-7-dihydro-4h-thieno-2-3-c-pyran-2-yl-lh-pyrazole-5-carboxamide-glpg1837-a-novel-potentiator-which-can-open-class-iii-mutant-cystic-fibrosis-transmembrane-conductance-regulator-cftr-channels-to-a-high-extent
#6
Steven Emiel Van der Plas, Hans Kelgtermans, Tom De Munck, Sébastien Laurent Xavier Martina, Sébastien Dropsit, Evelyne Quinton, Ann De Blieck, Caroline Joannesse, Linda Tomaskovic, Mia Jans, Thierry Christophe, Ellen Van der Aar, Monica Borgonovi, Luc Nelles, Maarten Gees, Pieter Fw Stouten, Jan Van Der Schueren, Oscar Mammoliti, Katja Conrath, Martin J Andrews
Cystic fibrosis (CF) is caused by mutations in the gene for the cystic fibrosis transmembrane conductance regulator (CFTR). With the discovery of Ivacaftor and Orkambi, it has been shown that CFTR function can be partially restored by administering one or more small molecules. These molecules aim at either enhancing the amount of CFTR on the cell surface (correctors) or at improving the gating function of the CFTR channel (potentiators). Here we describe the discovery of a novel potentiator GLPG1837 which shows enhanced efficacy on CFTR mutants harboring Class III mutations compared to Ivacaftor, the first marketed potentiator...
November 17, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29148428/-sup-135-sup-la-as-an-auger-electron-emitter-for-targeted-internal-radiotherapy
#7
Jesper Fonslet, Boon Quan Lee, Thuy A Tran, Mattia Siragusa, Mikael Jensen, Tibor Kibedi, Andrew E Stuchbery, Gregory W Severin
<b>Introduction:</b> <sup>135</sup>La has favorable nuclear and chemical properties for Auger-based targeted internal radiotherapy. Here we present detailed investigations of the production, emissions, imaging characteristics, and dosimetry related to <sup>135</sup>La therapy. <b>Methods and Results:</b> <sup>135</sup>La was produced by 16.5 MeV proton irradiation of metallic <sup>nat</sup>Ba on a medical cyclotron, and was isolated and purified by trap-and-release on weak cation-exchange resin...
November 17, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29148142/outcomes-of-primary-percutaneous-coronary-intervention-in-acute-myocardial-infarction-due-to-unprotected-left-main-thrombosis-the-asia-pacific-left-main-st-elevation-registry-aster
#8
Jonathan Yap, Gagan D Singh, Jung-Sun Kim, Krishan Soni, Kelvin Chua, Alvin Neo, Choong Hou Koh, Ehrin J Armstrong, Stephen W Waldo, Kendrick A Shunk, Reginald I Low, Myeong-Ki Hong, Yangsoo Jang, Khung Keong Yeo
INTRODUCTION: Prior studies of ULM STEMI have been confined to small cohorts. Recent registry data with larger patient cohorts have shown contrasting results. We aim to study the outcomes of patients with unprotected left main (ULM) ST-elevation myocardial infarction (STEMI) who underwent primary percutaneous coronary intervention (PCI). METHODS: The Asia-pacific left main ST-Elevation Registry (ASTER) is a multicenter retrospective registry involving 4 sites in Singapore, South Korea, and the United States...
November 16, 2017: Journal of Interventional Cardiology
https://www.readbyqxmd.com/read/29146874/imaging-characteristics-of-venous-parenchymal-abnormalities
#9
Audrey Arnoux, Aude Triquenot-Bagan, Daniela Andriuta, David Wallon, Evelyne Guegan-Massardier, Claire Leclercq, Olivier Martinaud, Mélody Castier-Amouyel, Olivier Godefroy, Jean-Marc Bugnicourt
BACKGROUND AND PURPOSE: There are few published data on the patterns of parenchymal imaging abnormalities in a context of cerebral venous thrombosis (CVT). The objectives of the present study were to describe the patterns of parenchymal lesions associated with CVT and to determine the lesion sites. METHODS: We included 44 consecutively hospitalized patients with CVT and parenchymal lesions on magnetic resonance imaging. The diagnosis of CVT had been confirmed by magnetic resonance imaging/magnetic resonance venography...
November 16, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29146563/characterization-of-the-ipec-j2-mdr1-ip-gp-cell-line-as-a-tool-for-identification-of-p-gp-substrates
#10
Burak Ozgür, Lasse Saaby, Kristine Langthaler, Birger Brodin
Recently, we transfected the porcine intestinal cell line IPEC-J2, with human P-glycoprotein (P-gp, ABCB1). The resulting cell line, iP-gp, has a high expression of functional human P-gp in the apical membrane, and a low expression of nonhuman ATP-binding cassette (ABC) transporters. The aim of the present work was to investigate the usability of iP-gp cell line for determining transepithelial transport kinetics of the prototypical P-gp substrates digoxin and rhodamine 123. The cell line generated tight monolayers after 16days of culture, reflected by high transepithelial electrical resistance values (TEER>15,000Ω·cm(2)), immunocytochemistry and low fluxes of the paracellular flux marker [(14)C]-mannitol...
November 13, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29146525/maternal-nutritional-determinants-of-colostrum-fatty-acids-in-the-eden-mother-child-cohort
#11
Martine Armand, Jonathan Y Bernard, Anne Forhan, Barbara Heude, Marie-Aline Charles
BACKGROUND & AIMS: Programming of infant development and later health may depend on early-milk polyunsaturated fatty acids (PUFA) contents, that are very variable between women for reasons not well elucidated. Indeed, a high n-6/n-3 PUFA in milk was associated with higher adiposity, arterial pressure and lower psychomotor scores in childhood. We aimed to explore the respective contribution of several maternal and perinatal factors to the variability of linoleic (LA), α-linolenic (ALA), arachidonic (AA), and docosahexaenoic (DHA) acid levels in early milk...
October 21, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29146413/ct-fluoroscopy-guided-core-needle-biopsy-of-anterior-mediastinal-masses
#12
T Iguchi, T Hiraki, Y Matsui, H Fujiwara, J Sakurai, Y Masaoka, M Uka, T Tanaka, H Gobara, S Kanazawa
OBJECTIVE: To retrospectively evaluate the safety, diagnostic yield, and risk factors of diagnostic failure of computed tomography (CT) fluoroscopy-guided biopsies of anterior mediastinal masses. MATERIALS AND METHODS: Biopsy procedures and results of anterior mediastinal masses in 71 patients (32 women/39 men; mean [±standard deviation] age, 53.8±20.0years; range, 14-88years) were analyzed. Final diagnoses were based on surgical outcomes, imaging findings, or clinical follow-up findings...
November 13, 2017: Diagnostic and Interventional Imaging
https://www.readbyqxmd.com/read/29146138/development-of-kidney-transplant-fibrosis-is-inversely-associated-with-plasma-marine-fatty-acid-level
#13
Ivar A Eide, Christina Dörje, My Svensson, Trond Jenssen, Clara Hammarstrøm, Helge Scott, Kristian S Bjerve, Jeppe H Christensen, Erik B Schmidt, Anders Hartmann, Anders Åsberg, Anna V Reisæter, Finn P Reinholt
OBJECTIVE(S): We assessed associations between plasma levels of polyunsaturated fatty acids (PUFAs) and degree of inflammation and interstitial fibrosis in transplanted kidneys. DESIGN: The design of the study was single center cohort study. SUBJECTS: A study population of 156 patients who received a kidney transplant at Oslo University Hospital during 2010. MAIN OUTCOME MEASURE: Kidney transplant biopsies were obtained at 2 months and 1 year after transplantation...
November 14, 2017: Journal of Renal Nutrition
https://www.readbyqxmd.com/read/29145657/the-utility-of-blood-neuroendocrine-gene-transcript-measurement-in-the-diagnosis-of-bronchopulmonary-neuroendocrine-tumours-and-as-a-tool-to-evaluate-surgical-resection-and-disease-progression
#14
Pier Luigi Filosso, Mark Kidd, Matteo Roffinella, Anna Lewczuk, Kyung-Min Chung, Agnieszka Kolasinska-Cwikla, Jaroslaw Cwikla, Anna Lowczak, Anna Doboszynska, Anna Malczewska, Maria Catalano, Valentina Zunino, Monica Boita, Emanuela Arvat, Riccardo Cristofori, Francesco Guerrera, Alberto Oliaro, Margot Tesselaar, Wieneke Buikhuisen, Beata Kos-Kudla, Mauro Papotti, Lisa Bodei, Ignat Drozdov, Irvin Modlin
OBJECTIVES: The management of bronchopulmonary neuroendocrine tumours (BPNETs) is difficult, since imaging, histology and biomarkers have a limited value in diagnosis, predicting outcome and defining therapeutic efficacy. We evaluated a NET multigene blood test (NETest) to diagnose BPNETs, assess disease status and evaluate surgical resection. METHODS: (i) Diagnostic cohort: BP carcinoids (n = 118)-typical carcinoid, n = 67 and atypical carcinoid, n = 51; other lung NEN (large-cell neuroendocrine carcinoma and small-cell lung carcinoma, n = 13); adenocarcinoma, (n = 26); squamous cell carcinoma (n = 23); controls (n = 90) and chronic obstructive pulmonary disease (n = 18)...
November 13, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29145598/pubertal-escape-from-estradiol-negative-feedback-in-ewe-lambs-is-not-accounted-for-by-decreased-esr1-mrna-or-protein-in-kisspeptin-neurons
#15
Michelle N Bedenbaugh, Marcella D'Oliveira, Rodolfo C Cardoso, Stanley M Hileman, Gary L Williams, Marcel Amstalden
In this study, we investigated whether decreased sensitivity to estradiol negative feedback is associated with reduced ESR1 expression in kisspeptin neurons as ewe lambs approach puberty. Lambs were ovariectomized and received no implant (OVX) or an implant containing estradiol (OVX+E). In the middle arcuate nucleus (mARC), ESR1 mRNA was greater in OVX than OVX+E lambs but did not differ elsewhere. Posthoc analysis of LH secretion from OVX+E lambs revealed three patterns of LH pulsatility: low (1-2 pulses/12 h; LF, n=3), moderate (6-7 pulses/12 h; MF, n=6) and high (>10 pulses/12 h; HF, n=5)...
November 14, 2017: Endocrinology
https://www.readbyqxmd.com/read/29145536/the-effects-of-vitamin-d-supplementation-in-newly-diagnosed-type-1-diabetes-patients-systematic-review-of-randomized-controlled-trials
#16
Elina Gregoriou, Ioannis Mamais, Irene Tzanetakou, Giagkos Lavranos, Stavri Chrysostomou
AIM: The aim of this study was to examine the effects of vitamin D supplementation in patients newly diagnosed with type 1 diabetes (T1D) assessed by insulin needs and changes in glycemic indices, as evidenced by randomized controlled trials (RCTs). METHODS: A total of 7 RCTs were retrieved from PubMed/Medline and EBSCO databases by MeSH term search, and were reviewed systematically. The RCTs included examined the effects of alphacalcidole (n = 2), cholecalciferol (n = 2), and calcitriol (n = 3) supplementation on changes in daily insulin dose (DID), fasting Cpeptide (FCP), stimulated C-peptide (SCP), and HbA1c...
July 2017: Review of Diabetic Studies: RDS
https://www.readbyqxmd.com/read/29145299/prophylactic-temporary-abdominal-aorta-balloon-occlusion-in-women-with-placenta-previa-accretism-during-late-gestation
#17
Zhongyuan Qiu, Jifen Hu, Jianbo Wu, Lihong Chen
BACKGROUND: To evaluate the clinical efficacy of prophylactic temporary balloon occlusion of the abdominal aorta in patients with placenta previa accretism during cesarean section. METHODS: Twenty-three consecutive patients, prenatally confirmed with placenta previa accretism were retrospectively analyzed in our center from August 2012 to October 2014. All 23 subjects underwent cesarean section with prophylactic balloon occlusion of the abdominal aorta. RESULTS: All of the 23 subjects experienced singleton pregnancies leading to the birth of live infants...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29144985/a-phase-1-2-study-of-rigosertib-in-patients-with-myelodysplastic-syndromes-mds-and-mds-progressed-to-acute-myeloid-leukemia
#18
Shyamala C Navada, Steven M Fruchtman, Rosalie Odchimar-Reissig, Erin P Demakos, Michael E Petrone, Patrick S Zbyszewski, James F Holland, Lewis R Silverman
This Phase 1/2, dose-escalating study of rigosertib enrolled 22 patients with higher-risk myelodysplastic syndromes (MDS) (n=9) and acute myeloid leukemia (AML; n=13) who had relapsed or were refractory to standard therapy and for whom no second-line therapies were approved. Patients received 3- to 7-day continuous intravenous infusions of rigosertib, an inhibitor of Ras-effector pathways that interacts with the Ras-binding domains, common to several signaling proteins including Raf and PI3 kinase. Rigosertib was administered at doses of 650-1700mg/m(2)/day in 14-day cycles...
November 11, 2017: Leukemia Research
https://www.readbyqxmd.com/read/29144886/comparative-effectiveness-of-proactive-tobacco-treatment-among-smokers-with-and-without-chronic-lower-respiratory-disease
#19
Anne C Melzer, Barbara Clothier, Sandra J Japuntich, Siamak Noorbaloochi, Patrick Hammett, Diana J Burgess, Anne M Joseph, Steven S Fu
RATIONALE: Adults with chronic lower respiratory disease (CLRD) differ in their barriers to smoking cessation, but also suffer from tobacco related health concerns, which may motivate quit attempts. Few studies have examined differences in tobacco treatment response between smokers with and without CLRD. OBJECTIVE: We examined the effectiveness of a proactive outreach program for cessation among smokers with and without CLRD. METHODS: Subgroup analysis of the Veterans VICTORY Over Tobacco Study, a pragmatic randomized controlled trial that demonstrated the effectiveness of proactive outreach and the choice of tobacco treatments compared to usual care...
November 16, 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/29143871/head-and-neck-rhabdomyosarcoma-in-children-a-20-year-retrospective-study-at-a-tertiary-referral-center
#20
Sophia Marie Häußler, Carmen Stromberger, Heidi Olze, Georg Seifert, Steffen Knopke, Arne Böttcher
OBJECTIVE: The purpose of this study was to assess rhabdomyosarcomas (RMS) of the head and neck in pediatric patients with regard to clinical presentation, treatment, and survival. METHODS: Data were retrospectively obtained from patient charts with regard to RMS of the head and neck diagnosed between 1996 and 2016 at a tertiary referral center. Clinical course, treatment modalities, and side effects were analyzed. Survival analysis was carried out using the Kaplan-Meier method...
November 16, 2017: Journal of Cancer Research and Clinical Oncology
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