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Interbody Bone Fusion

L Hattou, X Morandi, J Lefebvre, P-J Le Reste, L Riffaud, P-L Hénaux
PURPOSE: The aim of this study was to assess the interbody fusion rate for patients treated by anterior cervical interbody fusion (ACIF) using polyetheretherketone (PEEK) cages filled with synthetic bone graft in acute cervical spine injury. MATERIALS AND METHODS: Twenty-nine patients (mean age: 49 years) with monosegmental instability due to cervical spine injury were followed. We assessed the rate of and time to interbody fusion at 1-year follow-up. In case of secondary displacement, we analysed its causes and surgical management...
October 5, 2016: Orthopaedics & Traumatology, Surgery & Research: OTSR
Md Shah Alam, Kevin Phan, Rezaul Karim, Sharif Ahmed Jonayed, Hasan Khalid Md Munir, Shubhendu Chakraborty, Tashfique Alam
BACKGROUND: Tuberculosis (TB) of the spine is a common site of osseous TB, accounting for 50%-60% of cases. Spinal TB still occurs in both developed and developing countries. The diagnosis of spinal TB is difficult and it commonly presents at an advanced stage. Delays in establishing diagnosis and management result in complications such as spinal cord compression and spinal deformity. METHODS: A total of 582 patients with TB of the cervical, thoracic and lumbar spine with moderate to severe cord compression were studied...
December 2015: J Spine Surg
Sukrit Jain, Adam E M Eltorai, Roy Ruttiman, Alan H Daniels
Since the late 1980s, spinal interbody cages (ICs) have been used to aid bone fusion in a variety of spinal disorders. Utilized to restore intervertebral height, enable bone graft containment for arthrodesis, and restore anterior column biomechanical stability, ICs have since evolved to become a highly successful means of achieving fusion, being associated with less postoperative pain, shorter hospital stay, fewer complications and higher rates of fusion when than bone graft only spinal fusion. IC design and materials have changed considerably over the past two decades...
August 2016: Orthopaedic Surgery
Kevin Phan, Ralph J Mobbs
Anterior lumbar interbody fusion (ALIF) is one of the surgical procedures for the relief of chronic back pain, radiculopathy and neurogenic claudication in patients with degenerative lumbar spine disease that is refractory to conservative therapy, low-grade spondylolisthesis and pseudo arthrosis. Over the past half century, both the surgical techniques and instrumentation required for ALIF have changed significantly. In particular, the designs of ALIF cage and the materials used have evolved dramatically, the common goal being to improve fusion rates and optimize clinical outcomes...
August 2016: Orthopaedic Surgery
Mingzheng Zhang, Fang Pu, Liqiang Xu, Linlin Zhang, Hang Liang, Deyu Li, Yu Wang, Yubo Fan
Spinal cages are used to create a suitable mechanical environment for interbody fusion in cases of degenerative spinal instability. Due to individual variations in bone structures and pathological conditions, patient-specific cages can provide optimal biomechanical conditions for fusion, strengthening patient recovery. Finite element analysis (FEA) is a valuable tool in the biomechanical evaluation of patient-specific cage designs, but the time- and labor-intensive process of modeling limits its clinical application...
September 14, 2016: Computer Methods in Biomechanics and Biomedical Engineering
Man Kyu Choi, Sung Bum Kim, Chang Kyu Park, Hridayesh P Malla, Sung Min Kim
STUDY DESIGN: A retrospective study. OBJECTIVE: To investigate the relationship between trunk muscle cross-sectional area (MCSA) and fusion rate after posterior lumbar interbody fusion using pedicle screw fixation (PLIF-PSF). SUMMARY OF BACKGROUND DATA: Although trunk muscles of the lumbar spine contribute to spinal stability and alignment, effect of trunk muscles on spinal fusion rate and time to fusion is unclear. METHODS: A total of 192 adult patients with degenerative lumbar disease who underwent PLIF-PSF at L3-L4 or L4-L5 were included...
September 10, 2016: Clinical Spine Surgery
Marjan Alimi, Rodrigo Navarro-Ramirez, Karishma Parikh, Innocent Njoku, Christoph P Hofstetter, Apostolos J Tsiouris, Roger Härtl
STUDY DESIGN: Retrospective cohort study. OBJECTIVE: To evaluate the radiographic and clinical outcome of silicate-substituted calcium phosphate (Si-CaP), utilized as a graft substance in spinal fusion procedures. SUMMARY OF BACKGROUND DATA: Specific properties of Si-CaP provide the graft with negative surface charge that can result in a positive effect on the osteoblast activity and neovascularization of the bone. METHODS: This study included those patients who underwent spinal fusion procedures between 2007 and 2011 in which Si-CaP was used as the only bone graft substance...
September 10, 2016: Clinical Spine Surgery
Hironobu Sakaura, Toshitada Miwa, Tomoya Yamashita, Yusuke Kuroda, Tetsuo Ohwada
STUDY DESIGN: Clinical case series. PURPOSE: In the posterior lumbar interbody fusion (PLIF) procedure in our institute, the cephalad screw trajectory follows a mediolateral and caudocephalad directed path according to the original cortical bone trajectory (CBT) method. However, the starting point of the caudal screw is at the medial border of the pedicle on an articular surface of the superior articular process, and the trajectory takes a mediolateral path parallel to the cephalad endplate...
August 2016: Asian Spine Journal
William R Walsh, Matthew H Pelletier, Nicky Bertollo, Chris Christou, Chris Tan
BACKGROUND: Polyetheretherketone (PEEK) has a wide range of clinical applications but does not directly bond to bone. Bulk incorporation of osteoconductive materials including hydroxyapatite (HA) into the PEEK matrix is a potential solution to address the formation of a fibrous tissue layer between PEEK and bone and has not been tested. QUESTIONS/PURPOSES: Using in vivo ovine animal models, we asked: (1) Does PEEK-HA improve cortical and cancellous bone ongrowth compared with PEEK? (2) Does PEEK-HA improve bone ongrowth and fusion outcome in a more challenging functional ovine cervical fusion model? METHODS: The in vivo responses of PEEK-HA Enhanced and PEEK-OPTIMA(®) Natural were evaluated for bone ongrowth in the form of dowels implanted in the cancellous and cortical bone of adult sheep and examined at 4 and 12 weeks as well as interbody cervical fusion at 6, 12, and 26 weeks...
November 2016: Clinical Orthopaedics and related Research
Dong-Ju Yun, Byeong-Wook Hwang, Hyeong-Seok Oh, Jin-Sung Kim, Sang-Hyeop Jeon, Sang-Ho Lee
BACKGROUND: Percutaneous vertebral augmentation with cement is used as a salvage procedure for failed instrumentation. However, few studies have reported the use of this procedure for failed anterior lumbar fusion in elderly patients with osteoporosis and other complicated diseases who have undergone a previous major operation. METHODS: Between January 2007 and December 2015, the clinical and radiographic results of 8 patients with osteoporosis who showed subsidence and migration of the implant after an initial operation were examined...
August 18, 2016: World Neurosurgery
Hai-yu Shao, Jun Zhang, Di Yang, Jin-ping Chen, Ya-zeng Huang
OBJECTIVE: To compare clinical efficacy of Zero-profile implant for anterior cervical discectomy and fusion and conventional titanium plate with cage internal fixation for the treatment of single segmental cervical intervertebral disc herniation. METHODS: From August 2011 to March 2014, clinical data of 139 patients with single cervical disc herniation treated with anterior cervical discectomy and interbody fusion with internal fixation were retrospectively analyzed...
June 2016: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
Jae Hyup Lee, Chang-Bae Kong, Jae Jun Yang, Hee-Jong Shim, Ki-Hyoung Koo, Jeehyuong Kim, Choon-Ki Lee, Bong-Soon Chang
BACKGROUND CONTEXT: The CaO-SiO2-P2O5-B2O3 glass ceramics spacer generates chemical bonding to adjacent bones with high mechanical stability to produce a union with the endplate and ultimately, stability. PURPOSE: The authors aimed to compare the clinical efficacy and safety of CaO-SiO2-P2O5-B2O3 glass ceramics with a titanium cage that is widely used for PLIF surgery in the clinical field. STUDY DESIGN/SETTING: Prospective, stratified randomized, multi-center, single-blinded, comparator-controlled non-inferiority trial PATIENT SAMPLE: This study was conducted in 4 hospitals and enrolled a total of 86 patients between 30 and 80 years of age who required one-level PLIF due to severe spinal stenosis, spondylolisthesis, or huge disc herniation...
August 3, 2016: Spine Journal: Official Journal of the North American Spine Society
Dae Hwan Kim, Nam Lee, Dong Ah Shin, Seong Yi, Keung Nyun Kim, Yoon Ha
OBJECTIVE: To compare the fusion rate of a hydroxyapatite demineralized bone matrix (DBM) with post-laminectomy acquired autograft in lumbar interbody fusion surgery and to evaluate the correlation between fusion rate and clinical outcome. METHODS: From January 2013 to April 2014, 98 patients underwent lumbar interbody fusion surgery with hydroxyapatite DBM (HA-DBM group) in our institute. Of those patients, 65 received complete CT scans for 12 months postoperatively in order to evaluate fusion status...
July 2016: Journal of Korean Neurosurgical Society
Shang-Won Yu, Chin-Hsien Wu, James Jih-Hsi Yeh, Cheng-Yo Yen, Ching-Hou Ma, Yuan-Kun Tu
STUDY DESIGN: Retrospective study. OBJECTIVE: To assess the safety and efficacy of iliac crest defect reconstruction using Kirschner-wire (K-wire)/polymethylmethacrylate (PMMA) versus traditional autologous rib graft reconstruction. SUMMARY OF BACKGROUND DATA: The iliac crest has been the preferred donor site for strut bone graft for various spinal fusion surgeries. METHODS: Seventy-three patients [44 males and 29 females (average age: 57...
July 14, 2016: Clinical Spine Surgery
Lei Dang, Yu Sun, Shaobo Wang, Shengfa Pan, Mai Li, Li Zhang, Fengshan Zhang
PURPOSE: This study is to share our experience of a modified anterior cervical discectomy and fusion (ACDF) procedure with a new source of autograft bone for interbody fusion. METHODS: The same procedure was performed in 893 cases where autograft was obtained from the osteophytes and/or the reams of vertebrae. For each case, radiological fusion rate and clinical outcome were followed up for 3 and 12 months after surgery. RESULTS: For one to three-level ACDF, fusion rates were from 67...
July 17, 2016: British Journal of Neurosurgery
Mohamed Macki, Sbaa Syeda, Panagiotis Kerezoudis, Ali Bydon, Timothy F Witham, Daniel M Sciubba, Jean-Paul Wolinsky, Mohamad Bydon, Ziya Gokaslan
The objective of this independent study is to determine the impact of recombinant human bone morphogenetic protein 2 (rhBMP-2) on reoperation for pseudarthrosis and/or instrumentation failure. A nested case-control study of first-time posterolateral, instrumented fusion of the lumbar spine for degenerative spinal disease was undertaken. Cases of reoperation for pseudoarthrosis and/or instrumentation failure were assigned to controls, who did not experience the primary outcome measure at the time of reoperation...
October 2016: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
Yu-Xiang Wang, Hong-Qi Zhang, Ming-Xing Tang, Chao-Feng Guo, Ang Deng, Jian-Huang Wu, Jin-Yang Liu, Zhansheng Deng, Jing Chen
PURPOSE: The purpose of this study was to determine the efficacy and feasibility of surgical management of children with thoracolumbar spine tuberculosis with kyphosis by using one-stage posterior focus debridement, interbody grafts, and posterior instrumentation and fusion. METHODS: From October 2010 to September 2013, 21 children with thoracolumbar spinal tuberculosis accompanied by kyphosis were treated with one-stage posterior decompression, interbody grafts, and posterior instrumentation and fusion...
August 2016: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
Pei-I Tsai, Ching-Chi Hsu, San-Yuan Chen, Tsung-Han Wu, Chih-Chieh Huang
Traditional solid cages have been widely used in posterior lumbar interbody fusion (PLIF) surgery. However, solid cages significantly affect the loading mechanism of the human spine due to their extremely high structural stiffness. Previous studies proposed and investigated porous additive manufactured (AM) cages; however, their biomechanical performances were analyzed using oversimplified bone-implant numerical models. Thus, the aim of this study was to investigate the outer shape and inner porous structure of the AM cages...
September 1, 2016: Computers in Biology and Medicine
Ian Rodway, Julie Gander
Background. This retrospective, two cohort series study was designed to compare a room temperature, glycerol-preserved composite pinned bone allograft (G-CPBA) with the same graft type provided in a frozen state (F-CPBA) for use as a cervical interbody spacer in anterior cervical discectomy and fusion (ACDF). Methods. A comprehensive chart review was performed for 67 sequential patients that received either a F-CPBA or a G-CPBA and had at least one-year follow-up. Twenty-eight patients had received G-CPBA grafts and 37 patients had received F-CPBA grafts...
2014: International Scholarly Research Notices
Kyu Won Oh, Jae Hyup Lee, Ji-Ho Lee, Do-Yoon Lee, Hee Jong Shim
STUDY DESIGN: A retrospective review of prospectively collected radiographic and clinical data. OBJECTIVE: This study aims to investigate the relationship between cage subsidence and bone mineral density (BMD), and to reveal the clinical implications of cage subsidence. SUMMARY OF BACKGROUND DATA: Posterior lumbar interbody fusion (PLIF) has become one of the standard treatment modality for lumbar degenerative disease. However, cage subsidence might result in recurrent foraminal stenosis and deteriorate the clinical results...
June 28, 2016: Clinical Spine Surgery
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