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Intervertebral Disc Mechanics

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https://www.readbyqxmd.com/read/29329586/il-33-st2-signaling-contributes-to-radicular-pain-by-modulating-mapk-and-nf-%C3%AE%C2%BAb-activation-and-inflammatory-mediator-expression-in-the-spinal-cord-in-rat-models-of-noncompressive-lumber-disk-herniation
#1
Si-Jian Huang, Jian-Qin Yan, Hui Luo, Lu-Yao Zhou, Jian-Gang Luo
BACKGROUND: Immune and inflammatory responses occurring in the spinal cord play a pivotal role in the progression of radicular pain caused by intervertebral disk herniation. Interleukin-33 (IL-33) orchestrates inflammatory responses in a wide range of inflammatory and autoimmune disorders of the nervous system. Thus, the purpose of this study is to investigate the expression of IL-33 and its receptor ST2 in the dorsal spinal cord and to elucidate whether the inhibition of spinal IL-33 expression significantly attenuates pain-related behaviors in rat models of noncompressive lumbar disc herniation...
January 12, 2018: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29323102/propionibacterium-acnes-induces-intervertebral-disc-degeneration-by-promoting-nucleus-pulposus-cell-apoptosis-via-the-tlr2-jnk-mitochondrial-mediated-pathway
#2
Yazhou Lin, Yucheng Jiao, Ye Yuan, Zezhu Zhou, Yuehuan Zheng, Jiaqi Xiao, Changwei Li, Zhe Chen, Peng Cao
Evidence suggests that intervertebral disc degeneration (IVDD) can be induced by Propionibacterium acnes (P. acnes), although the underlying mechanisms are unclear. In this study, we analyzed the pathological changes in degenerated human intervertebral discs (IVDs) infected with P. acnes. Compared with P. acnes-negative samples, P. acnes-positive IVDs showed increased apoptosis of nucleus pulposus cells (NPCs) concomitant with severe IVDD. Then, a P. acnes-inoculated IVD animal model was established, and severe IVDD was induced by P...
January 10, 2018: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/29320615/an-intervertebral-disc-whole-organ-culture-system-to-investigate-proinflammatory-and-degenerative-disc-disease-condition
#3
Gernot Lang, Yishan Liu, Janna Geries, Zhiyu Zhou, David Kubosch, Norbert Südkamp, R Geoff Richards, Mauro Alini, Sibylle Grad, Zhen Li
OBJECTIVE: The aim of this study was to compare the effect of different disease initiators of degenerative disc disease (DDD) within an intervertebral disc (IVD) organ culture system, and to understand the interplay between inflammation and degeneration in the early stage of DDD. DESIGN: Bovine caudal IVDs were cultured within a bioreactor for up to 11 days. Control group was cultured under physiological loading (0.02-0.2 MPa; 0.2 Hz; 2h/day) and high glucose (4...
January 10, 2018: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/29319178/glucose-enhances-aggrecan-expression-in-chondrocytes-via-the-pkc%C3%AE-p38-mir141-3p-signaling-pathway
#4
REVIEW
Tsung-Ju Wu, Yi-Chin Fong, Chih-Yang Lin, Yuan-Li Huang, Chih-Hsin Tang
Aggrecan is a high molecular weight proteoglycan that plays a critical role in cartilage structure and the function of joints, providing intervertebral disc and cartilage with the ability to resist compressive loads. Aggrecan degradation in articular cartilage is a significant event in early-stage osteoarthritis (OA). Currently, no effective treatment exists for OA other than pain relief. Dextrose (D-glucose) prolotherapy has shown promising activity in the treatment of different musculoskeletal disorders, including OA...
January 10, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29315127/tidemark-avulsions-are-a-predominant-form-of-endplate-irregularity
#5
Britta Berg-Johansen, Deeptee Jain, Ellen C Liebenberg, Aaron J Fields, Thomas M Link, Conor W O'Neill, Jeffrey C Lotz
STUDY DESIGN: Descriptive histologic and MRI study of human cadaveric spines. OBJECTIVE: To identify and characterize common endplate pathologies to form a histologic foundation for an etiology-based classification system. SUMMARY OF BACKGROUND DATA: Irregularities at the spinal disc-vertebra interface are associated with back pain and intervertebral disc herniation injuries. However, there is currently a lack of consensus regarding terminology for classification...
January 8, 2018: Spine
https://www.readbyqxmd.com/read/29314724/genipin-cross-linked-type-ii-collagen-scaffold-promotes-the-differentiation-of-adipose-derived-stem-cells-into-nucleus-pulposus-like-cells
#6
Xiaopeng Zhou, Yiqing Tao, Erman Chen, Jingkai Wang, Weijing Fang, Tengfei Zhao, Chengzhen Liang, Fangcai Li, Qixin Chen
Adipose-derived stem cells (ADSCs)-based tissue engineering was a promising method to treat intervertebral disc degeneration. Type II collagen is a native component in the nucleus pulposus (NP), and has the ability to promote ADSCs to differentiate into NP-like cells. In this article, we aimed to establish a genipin-cross-linked three-dimensional (3D) type II collagen scaffold, and determine the biological effects of the scaffold on ADSCs differentiating into a NP-like phenotype. Different concentrations of genipin were used to cross-link the 3D type II collagen scaffold...
January 3, 2018: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/29314237/nondestructive-indirect-assessment-of-the-biomechanical-properties-of-the-rat-intervertebral-disc-using-contrast-enhanced-%C3%A2%C2%B5ct
#7
Michael D Newton, Samantha E Hartner, Karissa Gawronski, Erik J Davenport, Shannon C Timmons, Kevin C Baker, Tristan Maerz
Mechanical characterization of the intervertebral disc involves labor-intensive and destructive experimental methodology. Contrast-enhanced micro-computed tomography is a nondestructive imaging modality for high-resolution visualization and glycosaminoglycan quantification of cartilaginous tissues. The purpose of this study was to determine whether anionic and cationic contrast-enhanced micro-computed tomography of the intervertebral disc can be used to indirectly assess disc mechanical properties in an ex vivo model of disc degeneration...
January 4, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29312639/progranulin-derived-engineered-protein-atsttrin-suppresses-tnf-%C3%AE-mediated-inflammation-in-intervertebral-disc-degenerative-disease
#8
Hong Ding, Jianlu Wei, Yunpeng Zhao, Yi Liu, Lian Liu, Lei Cheng
Atsttrin, an engineered molecule composed of three fragments of progranulin(PGRN), exerts comparable anti-inflammation ability. Intervertebral disc degeneration (IDD) is involved in inflammation in which TNF-α plays a key role. This study aims to examine the effect and the mechanism of Atsttrin in the pathogenesis of intervertebral disc degeneration. For this purpose, we took advantage of murine and human intervertebral disc (IVD) and examined the expression of TNF-α in IVD tissues using immunohistochemistry and TNF-α level in peripheral sera by ELISA assay...
December 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29310504/the-effect-of-electromagnetic-fields-on-postoperative-pain-and-locomotor-recovery-in-dogs-with-acute-severe-thoracolumbar-intervertebral-disc-extrusion-a-randomized-placebo-controlled-prospective-clinical-trial
#9
Natalia Zidan, Joe Fenn, Emily Griffith, Peter J Early, Chris L Mariani, Karen R Munana, Julien Guevar, Natasha Olby
Spinal cord injury (SCI) due to acute intervertebral disc extrusions (IVDE) is common in dogs and is treated by surgical decompression. Dogs with sensorimotor complete injuries have an incomplete recovery. Pulsed electromagnetic fields (PEMF) reduce postoperative pain through anti-inflammatory effects and there is growing evidence for neuroprotective effects. This randomized, controlled clinical trial evaluated the effect of PEMF on post-operative pain and neurologic recovery in dogs with surgically treated sensorimotor complete SCI due to acute IVDE...
January 8, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29285559/pressure-induced-end-plate-fracture-in-the-porcine-spine-is-the-annulus-fibrosus-susceptible-to-damage
#10
Chelsea R Snow, Maxine Harvey-Burgess, Brigitte Laird, Stephen H M Brown, Diane E Gregory
PURPOSE: To determine if the mechanical properties of the annulus fibrosus (AF) are altered following end-plate fracture. Vertebral fractures, particularly those in the growth plate, are relatively common among adolescents. What is unclear is whether or not these fractures are also associated with concomitant damage to the intervertebral disc (IVD), in particular the AF. METHODS: The current study employed a high-rate IVD pressurization model to create growth plate fractures in the porcine cervical spine...
December 28, 2017: European Spine Journal
https://www.readbyqxmd.com/read/29259641/icariin-prevents-il-1%C3%AE-induced-apoptosis-in-human-nucleus-pulposus-via-the-pi3k-akt-pathway
#11
Xiangyu Deng, Wei Wu, Hang Liang, Donghua Huang, Doudou Jing, Dong Zheng, Zengwu Shao
Purpose: To explore the effect and possible mechanism of icariin, a prenylated flavonol glycoside derived from the Chinese herb Epimedium sagittatum that was applied to IL-1β pretreated human nucleus pulposus (NP) cells. Methods: Human NP cells were isolated from intervertebral discs of patients with scoliosis and lumbar spondylolisthesis. The cells were divided into five groups: A (blank control); B (20 ng/ml IL-1β); C (20 ng/ml IL-1β + 20 μM icariin); D (20 μM icariin + 20 ng/ml IL-1β + 25 μM LY294002); E (20 ng/ml IL-1β + 25 μM LY294002)...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29222837/low-melt-bioactive-glass-reinforced-3d-printing-akermanite-porous-cages-with-highly-improved-mechanical-properties-for-lumbar-spinal-fusion
#12
Xiurong Ke, Lei Zhang, Xianyan Yang, Juncheng Wang, Chen Zhuang, Zhouwen Jin, An Liu, Tengfei Zhao, Sanzhong Xu, Changyou Gao, Zhongru Gou, Guojing Yang
Although great strides have been made in medical technology, low back/neck pain and intervertebral disc degeneration initiated from disc degenerative disease remains a clinical challenge. Within the field of regenerative medicine therapy, we have sought to improve the biomechanical transformation of spinal fusion procedures conducted using biodegradable porous implants. Specifically, we have focused on developing mechanically strong bioceramic cages for spinal fusion and functional recovery. Herein we fabricated the akermanite (AKE) ceramic-based porous cages using low-melting bioactive glass (BG) and 3D printing technology...
December 9, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/29221904/tensile-behaviour-of-individual-fibre-bundles-in-the-human-lumbar-anulus-fibrosus
#13
Diana T Pham, Joe G Shapter, John J Costi
Disc degeneration is a common medical affliction whose origins are not fully understood. An improved understanding of its underlying mechanisms could lead to the development of more effective treatments. The aim of this paper was to investigate the effect of (1) degeneration, (2) circumferential region and (3) strain rate on the microscale mechanical properties (toe region modulus, linear modulus, extensibility, phase angle) of individual fibre bundles in the anulus fibrosus lamellae of the human intervertebral disc...
November 28, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/29214889/cell-seeded-adhesive-biomaterial-for-repair-of-annulus-fibrosus-defects-in-intervertebral-discs
#14
Michelle A Cruz, Warren W Hom, Distefano Tyler, Robert Merrill, Olivia M Torre, Huizi A Lin, Andrew Hecht, Svenja Illien-Junger, James C Iatridis
Defects in the annulus fibrosus (AF) of intervertebral discs allow nucleus pulposus tissue to herniate causing painful disability. Microdiscectomy procedures remove herniated tissue fragments but unrepaired defects remain allowing reherniation or progressive degeneration. Cell therapies show promise to enhance repair but methods are undeveloped and carriers are required to prevent cell leakage. To address this challenge, this study developed and evaluated genipin-crosslinked fibrin (FibGen) as an adhesive cell carrier optimized for AF repair that can deliver cells, match AF material properties and have low risk of extrusion during loading...
December 7, 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/29197741/exploration-about-changes-of-il-10-nf-%C3%AE%C2%BAb-and-mmp-3-in-a-rat-model-of-cervical-spondylosis
#15
Jianjian Yin, Kewei Ren, Yongjing Huang, Gongming Gao, Luming Nong, Nanwei Xu
OBJECTIVES: To investigate the relationship and mechanism between IL-10, NF-κB and MMP-3 in cervical degenerative disease induced by unbalanced dynamic and static forces in rats. METHODS: Sixty Sprague Dawley rats were randomized into test (n=45) and control (n=15) groups, which were randomly subdivided into three groups corresponding to one-month, three-month and six-month post-operation. Test group included 10, 15, 20 rats at corresponding postoperative stage and control group had five rats at each time point...
November 30, 2017: Molecular Immunology
https://www.readbyqxmd.com/read/29196238/tgf-%C3%AE-synergizes-with-ml264-to-block-il-1%C3%AE-induced-matrix-degradation-mediated-by-kr%C3%A3-ppel-like-factor-5-in-the-nucleus-pulposus
#16
Zi'ang Xie, Zhiwei Jie, Gangliang Wang, Xuewu Sun, Pan Tang, Shuai Chen, An Qin, Jian Wang, Shunwu Fan
Intervertebral disc degeneration causes low back pain.Interleukin-1β (IL-1β) is a well-known inflammatory mediator that is involved in disc degeneration but its molecular mechanisms on catabolic and anabolic events in nucleus pulposus (NP) cells remain unclear. Krüppel-like factor 5 (KLF5) is associated with inflammation and was previously shown to cause cartilage degradation. In this study, we revealed that KLF5 is involved in IL-1β activated NF-kB cascade by enhancing both p65 phosphorylation and p65 acetylation...
November 28, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29192178/characterisation-of-porous-knitted-titanium-for-replacement-of-intervertebral-disc-nucleus-pulposus
#17
Gauri Tendulkar, Vrinda Sreekumar, Frank Rupp, Arun K Teotia, Kiriaki Athanasopulu, Ralf Kemkemer, Alfred Buck, Alfred Buck, Hans-Peter Kaps, Jürgen Geis-Gerstorfer, Ashok Kumar, Andreas K Nussler
Effective restoration of human intervertebral disc degeneration is challenged by numerous limitations of the currently available spinal fusion and arthroplasty treatment strategies. Consequently, use of artificial biomaterial implant is gaining attention as a potential therapeutic strategy. Our study is aimed at investigating and characterizing a novel knitted titanium (Ti6Al4V) implant for the replacement of nucleus pulposus to treat early stages of chronic intervertebral disc degeneration. Specific knitted geometry of the scaffold with a porosity of 67...
November 30, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29189572/immunomodulation-of-human-mesenchymal-stem-stromal-cells-in-intervertebral-disc-degeneration-insights-from-a-proinflammatory-degenerative-ex-vivo-model
#18
Graciosa Q Teixeira, Catarina Leite Pereira, Joana R Ferreira, André F Maia, Maria Gomez-Lazaro, Mário A Barbosa, Cornelia Neidlinger-Wilke, Raquel M Goncalves
STUDY DESIGN: Ex vivo experimental study. OBJECTIVE: To investigate the effect of proinflammatory/degenerative intervertebral disc (IVD) microenvironment on the regenerative and immunomodulatory behavior of mesenchymal stem/stromal cells (MSCs), using an ex vivo model from bovine origin. SUMMARY OF BACKGROUND DATA: Low back pain (LBP) is a cause of disability worldwide, most frequently associated with IVD degeneration and inflammation, and characterized by increased levels of inflammatory mediators, often disregarded...
November 17, 2017: Spine
https://www.readbyqxmd.com/read/29188679/a-new-surgical-positioning-system-for-robotic-assisted-minimally-invasive-spine-surgery-and-transpedicular-approach-to-the-disc
#19
G Vadalà, D Accoto, F Russo, I Portaccio, M Rossini, S Valentini, R Papalia, V Denaro
Minimally Invasive Spine Surgery (MISS) procedures for the treatment of spinal pathologies have experienced exponential growth due to improved techniques and decreased trauma to the patient. Several MISS procedures that require the use of a trans-pedicular cannula as a guiding tool for pedicle screw placement, delivery of biomaterials to the vertebral body or injection of biologics to the disc space have been described. Although these are clear advantages of MISS, the limited dissection and exposure may reduce the accuracy and stability of operation and make spine surgeons rely heavily on intraoperative fluoroscopy, raising concerns over the level of radiation exposure...
October 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/29181144/evaluation-of-electrospun-nanofiber-anchored-silicone-for-the-degenerative-intervertebral-disc
#20
M Khandaker, S Riahanizad
The nucleus pulposus (NP) substitution by polymeric gel is one of the promising techniques for the repair of the degenerative intervertebral disc (IVD). Silicone gel is one of the potential candidates for a NP replacement material. Electrospun fiber anchorage to silicone disc, referred as ENAS disc, may not only improve the biomechanical performances of the gel but it can also improve restoration capability of the gel, which is unknown. This study successfully produced a novel process to anchor any size and shape of NP gel with electrospun fiber mesh...
2017: Journal of Healthcare Engineering
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