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https://www.readbyqxmd.com/read/29470277/does-duration-of-pain-at-baseline-influence-clinical-outcomes-of-low-back-pain-patients-managed-on-an-evidence-based-pathway
#1
Mary-Anne Jess, Ryan Cormac, Sharon Hamilton, Shaun Wellburn, Greg Atkinson, Charles Greenough, Andrew Coxon, Diarmaid Ferguson, Francis Fatoye, John Dickson, Andrea Jones, Denis Martin
Supplemental Digital Content is available in the text STUDY DESIGN.: Longitudinal observational study. OBJECTIVE: To investigate the association between the duration of pain at baseline and the clinical outcomes of patients with low back pain (LBP) enrolled on the North East of England Regional Back Pain and Radicular Pain Pathway (NERBPP). SUMMARY OF BACKGROUND DATA: The NERBPP is a clinical pathway based upon NICE guidelines (2009) for LBP of <1-year duration...
February 21, 2018: Spine
https://www.readbyqxmd.com/read/29470187/the-danish-gynecological-cancer-nursing-database-creating-evidence-for-quality-improvements-in-preoperative-and-postoperative-cancer-care
#2
Lene Seibæk, Dorthe Hjort Jakobsen, Claus Høgdall
OBJECTIVE: Quality of preoperative and postoperative care is crucial to improve postoperative outcome of cancer surgery and to ensure that neither complications nor a poor general condition delays any subsequent radiochemotherapy or recovery. On this background, the Danish Gynecological Cancer Database (DGCD) established a nursing database in 2011. The aim of DGCD Nursing is to monitor the quality of preoperative and postoperative care and to generate data for research. MATERIAL AND METHODS: In accordance with the current data protection legislation, real-time data are entered by clinical nurses at all national cancer centers...
February 22, 2018: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29468833/machine-learning-integration-of-rheumatoid-arthritis-synovial-histology-and-rnaseq-data-identifies-three-disease-subtypes
#3
Dana E Orange, Phaedra Agius, Edward F DiCarlo, Nicolas Robine, Heather Geiger, Jackie Szymonifka, Michael McNamara, Ryan Cummings, Kathleen M Andersen, Serene Mirza, Mark Figgie, Lionel Ivashkiv, Alessandra B Pernis, Caroline Jiang, Mayu Frank, Robert Darnell, Nithya Lingampali, Robinson William, Ellen Gravallese, Vivian P Bykerk, Susan M Goodman, Laura T Donlin
OBJECTIVE: We sought to refine histologic scoring of rheumatoid arthritis synovial tissue by training with gene expression data and machine learning. METHODS: Twenty histologic features were assessed on 129 synovial tissue samples. Consensus clustering was performed on gene expression data from a subset of 45 synovial samples. Support vector machine learning was used to predict gene expression subtypes using histology data as input. Corresponding clinical data were compared across subtypes...
February 22, 2018: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29468666/eicosanoids-prostacyclin-and-cyclooxygenase-in-the-cardiovascular-system
#4
REVIEW
Jane A Mitchell, Nicholas S Kirkby
Eicosanoids represent a diverse family of lipid mediators with fundamental roles in controlling physiology and disease. Within the eicosanoid super family are prostanoids, which are specifically derived from arachidonic acid by the enzyme cyclooxygenase (COX). COX has two isoforms; COX-1 and COX-2. COX-2 is the therapeutic target for the nonsteroidal anti-inflammatory drug (NSAID) class of pain medications. Of the prostanoids, prostacyclin, first discovered by Sir Professor John Vane in 1976, remains amongst the best studied and retains an impressive pedigree as one the bodies fundamental cardiovascular protective pathways...
February 21, 2018: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29468533/recalled-early-life-adversity-and-pain-the-role-of-mood-sleep-optimism-and-control
#5
Ambika Mathur, Jennifer E Graham-Engeland, Danica C Slavish, Joshua M Smyth, Richard B Lipton, Mindy J Katz, Martin J Sliwinski
Early life adversity (ELA) has been associated with pain symptomatology in adulthood, but mechanisms and moderators of these associations are unclear. Using recall based and concurrently assessed self-report data, we examined associations between ELA, mood, sleep, and recent pain intensity and interference, and whether optimism and perceived control weakened these associations in a midlife community sample of diverse adults reporting some ELA. Controlling for demographic variables and BMI, higher levels of ELA were associated with more pain intensity and interference; greater sleep disturbance and negative mood accounted for these associations...
February 21, 2018: Journal of Behavioral Medicine
https://www.readbyqxmd.com/read/29468000/an-accurate-diagnostic-pathway-helps-to-correctly-distinguish-between-the-possible-causes-of-acute-scrotum
#6
Beat Roth, Ioannis Giannakis, Meret Elisabeth Ricklin, George Niklaus Thalmann, Aristomenis Konstantinos Exadaktylos
Objectives: We sought to identify a simplified approach for the rapid differential diagnosis of patients presenting with acute scrotum. Methods: A total of 440 patients referred to the emergency department of the University Hospital of Bern, Switzerland, with acute scrotum between 2003 and 2013 were retrospectively analyzed. Simple and multiple binary logistic regression analyses were used to evaluate clinical and laboratory parameters that may help to distinguish between genital/paragenital infection and acute testicular torsion...
January 2018: Oman Medical Journal
https://www.readbyqxmd.com/read/29467289/protonation-state-of-inhibitors-determines-interaction-sites-within-voltage-gated-sodium-channels
#7
Amanda Buyan, Delin Sun, Ben Corry
Voltage-gated sodium channels are essential for carrying electrical signals throughout the body, and mutations in these proteins are responsible for a variety of disorders, including epilepsy and pain syndromes. As such, they are the target of a number of drugs used for reducing pain or combatting arrhythmias and seizures. However, these drugs affect all sodium channel subtypes found in the body. Designing compounds to target select sodium channel subtypes will provide a new therapeutic pathway and would maximize treatment efficacy while minimizing side effects...
February 21, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29467019/clinical-and-cost-effectiveness-of-the-star-care-pathway-compared-to-usual-care-for-patients-with-chronic-pain-after-total-knee-replacement-study-protocol-for-a-uk-randomised-controlled-trial
#8
Vikki Wylde, Wendy Bertram, Andrew D Beswick, Ashley W Blom, Julie Bruce, Amanda Burston, Jane Dennis, Kirsty Garfield, Nicholas Howells, Athene Lane, Candy McCabe, Andrew J Moore, Sian Noble, Tim J Peters, Andrew Price, Emily Sanderson, Andrew D Toms, David A Walsh, Simon White, Rachael Gooberman-Hill
BACKGROUND: Approximately 20% of patients experience chronic pain after total knee replacement. There is little evidence for effective interventions for the management of this pain, and current healthcare provision is patchy and inconsistent. Given the complexity of this condition, multimodal and individualised interventions matched to pain characteristics are needed. We have undertaken a comprehensive programme of work to develop a care pathway for patients with chronic pain after total knee replacement...
February 21, 2018: Trials
https://www.readbyqxmd.com/read/29465573/synovium-as-a-widespread-pathway-to-the-adjacent-joint-in-undifferentiated-high-grade-pleomorphic-sarcoma-of-the-tibia-a-case-report
#9
Xiaona Li, Zekun Zhang, Mahrukh Latif, Wei Chen, Jianling Cui, Zhigang Peng
RATIONALE: Undifferentiated high-grade pleomorphic sarcoma (UPS), originated from bone, is a rare tumor, accounting for 2% to 5% of all primary maligment bone neoplasms. Skip lesion can be found in undifferentiated high-grade pleomorphic sarcoma of bone (UPS-B). However, the direct invasion across the articular synovium to bone has not been reported previously. PATIENT CONCERNS: We report an unusual case of a 65-year-old man complained of a year history of pain, swelling, and limitation of activity in the left knee joint...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29464164/an-enhanced-recovery-after-surgery-pathway-for-microvascular-breast-reconstruction-is-safe-and-effective
#10
Arezoo Astanehe, Claire Temple-Oberle, Markus Nielsen, William de Haas, Robert Lindsay, Jennifer Matthews, David C McKenzie, Justin Yeung, Christiaan Schrag
Background: The aim of this study was to develop, implement, and evaluate a standardized perioperative enhanced recovery after surgery (ERAS) clinical care pathway in microsurgical abdominal-based breast reconstruction. Methods: Development of a clinical care pathway was informed by the latest ERAS guideline for breast reconstruction. Key features included shortened preoperative fasting, judicious fluids, multimodal analgesics, early oral nutrition, early Foley catheter removal, and early ambulation...
January 2018: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/29463867/optogenetic-tractography-for-anatomo-functional-characterization-of-cortico-subcortical-neural-circuits-in-non-human-primates
#11
S Senova, C Poupon, J Dauguet, H J Stewart, G P Dugué, C Jan, K Hosomi, G S Ralph, L Barnes, X Drouot, C Pouzat, J F Mangin, F Pain, I Doignon, R Aron-Badin, E Brouillet, E S Boyden, K A Mitrophanous, P Hantraye, S Palfi
Dissecting neural circuitry in non-human primates (NHP) is crucial to identify potential neuromodulation anatomical targets for the treatment of pharmacoresistant neuropsychiatric diseases by electrical neuromodulation. How targets of deep brain stimulation (DBS) and cortical targets of transcranial magnetic stimulation (TMS) compare and might complement one another is an important question. Combining optogenetics and tractography may enable anatomo-functional characterization of large brain cortico-subcortical neural pathways...
February 20, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29463258/the-association-between-subgroups-of-mri-findings-identified-with-latent-class-analysis-and-low-back-pain-in-40-year-old-danes
#12
Rikke K Jensen, Peter Kent, Tue S Jensen, Per Kjaer
BACKGROUND: Research into the clinical importance of spinal MRI findings in patients with low back pain (LBP) has primarily focused on single imaging findings, such as Modic changes or disc degeneration, and found only weak associations with the presence of pain. However, numerous MRI findings almost always co-exist in the lumbar spine and are often present at more than one lumbar level. It is possible that multiple MRI findings are more strongly associated with LBP than single MRI findings...
February 20, 2018: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29462700/eugenia-brasiliensis-leaves-extract-attenuates-visceral-and-somatic-inflammatory-pain-in-mice
#13
Róli R Simões, Scheila I Kraus, Igor S Coelho, Daniela Dal-Secco, Diogo A Siebert, Gustavo A Micke, Michele D Alberton, Adair R S Santos
ETHNOPHARMACOLOGICAL RELEVANCE: Eugenia brasiliensis Lam. (Myrtaceae) is a Brazilian tree distributed throughout Atlantic rain forest, since Bahia until Santa Catarina state, and is popularly known as "grumixaba, grumixameira, cumbixaba, ibaporoiti, and cereja-brasileira". The bark and leaves of Eugenia brasiliensis are used in folk medicine as adstringent, diuretic, energizing, anti-rheumatic and anti-inflammatory. This study aimed at investigating the chemical composition, antinociceptive and anti-inflammatory effect of the hydroalcoholic extract of Eugenia brasiliensis (HEEb)...
February 17, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29462326/secreted-frizzled-related-protein-2-sfrp2-expression-promotes-lesion-proliferation-via-canonical-wnt-signaling-and-indicates-lesion-borders-in-extraovarian-endometriosis
#14
T Heinosalo, M Gabriel, L Kallio, P Adhikari, K Huhtinen, T D Laajala, E Kaikkonen, A Mehmood, P Suvitie, H Kujari, T Aittokallio, A Perheentupa, M Poutanen
STUDY QUESTION: What is the role of SFRP2 in endometriosis? SUMMARY ANSWER: SFRP2 acts as a canonical WNT/CTNNB1 signaling agonist in endometriosis, regulating endometriosis lesion growth and indicating endometriosis lesion borders together with CTNNB1 (also known as beta catenin). WHAT IS KNOWN ALREADY: Endometriosis is a common, chronic disease that affects women of reproductive age, causing pain and infertility, and has significant economic impact on national health systems...
February 15, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29462012/neuroinflammation-and-central-sensitization-in-chronic-and-widespread-pain
#15
Ru-Rong Ji, Andrea Nackley, Yul Huh, Niccolò Terrando, William Maixner
Chronic pain is maintained in part by central sensitization, a phenomenon of synaptic plasticity, and increased neuronal responsiveness in central pain pathways after painful insults. Accumulating evidence suggests that central sensitization is also driven by neuroinflammation in the peripheral and central nervous system. A characteristic feature of neuroinflammation is the activation of glial cells, such as microglia and astrocytes, in the spinal cord and brain, leading to the release of proinflammatory cytokines and chemokines...
February 19, 2018: Anesthesiology
https://www.readbyqxmd.com/read/29461977/mosaic-ras-mapk-variants-cause-sporadic-vascular-malformations-which-respond-to-targeted-therapy
#16
Lara Al-Olabi, Satyamaanasa Polubothu, Katherine Dowsett, Katrina A Andrews, Paulina Stadnik, Agnel P Joseph, Rachel Knox, Alan Pittman, Graeme Clark, William Baird, Neil Bulstrode, Mary Glover, Kristiana Gordon, Darren Hargrave, Susan M Huson, Thomas S Jacques, Gregory James, Hannah Kondolf, Loshan Kangesu, Kim M Keppler-Noreuil, Amjad Khan, Marjorie J Lindhurst, Mark Lipson, Sahar Mansour, Justine O'Hara, Caroline Mahon, Anda Mosica, Celia Moss, Aditi Murthy, Juling Ong, Victoria E Parker, Jean-Baptiste Rivière, Julie C Sapp, Neil J Sebire, Rahul Shah, Branavan Sivakumar, Anna Thomas, Alex Virasami, Regula Waelchli, Zhiqiang Zeng, Leslie G Biesecker, Alex Barnacle, Maya Topf, Robert K Semple, E Elizabeth Patton, Veronica A Kinsler
BACKGROUND: Sporadic vascular malformations (VMs) are complex congenital anomalies of blood vessels that lead to stroke, life-threatening bleeds, disfigurement, overgrowth, and/or pain. Therapeutic options are severely limited and multi-disciplinary management remains challenging, particularly for high-flow arteriovenous malformations (AVM). METHODS: To investigate the pathogenesis of sporadic intracranial and extracranial VMs in 160 children in which known genetic causes had been excluded, we sequenced DNA from affected tissue and optimised analysis for detection of low mutant allele frequency...
February 20, 2018: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29461625/beyond-symptomatic-relief-for-chemotherapy-induced-peripheral-neuropathy-targeting-the-source
#17
REVIEW
Jiacheng Ma, Annemieke Kavelaars, Patrick M Dougherty, Cobi J Heijnen
Chemotherapy-induced peripheral neuropathy (CIPN) is a serious adverse side effect of many chemotherapeutic agents, affecting >60% of patients with cancer. Moreover, CIPN persists long into survivorship in approximately 20% to 30% of these patients. To the authors' knowledge, no drugs have been approved to date by the US Food and Drug Administration to effectively manage chemotherapy-induced neuropathic pain. The majority of the drugs tested for the management of CIPN aim at symptom relief, including pain and paresthesia, yet are not very efficacious...
February 20, 2018: Cancer
https://www.readbyqxmd.com/read/29460119/curcumin-inhibits-monocyte-chemoattractant-protein-1-expression-in-tnf-%C3%AE-induced-astrocytes-through-ampk-pathway
#18
Xingping Qin, Haowen Qiao, Songlin Wu, Jing Cheng, Qi Wan, Renzhong Liu
Curcumin, a phenolic pigment, plays an inhibitory role in astrocytes activation, a key step for neuropathic pain (NP). The present study aimed to investigate the mechanism behind the therapeutic effect of Curcumin on NP in vitro. Specifically, we investigated the inhibitory effect of Curcumin on tumor necrosis factor-α (TNF-α)-induced astrocyte migration. We also studied the effects of Curcumin on monocyte chemoattractant protein-1(MCP-1) expression and activity, as well as super oxide dismutase-2 (SOD2) expression and activity in TNF-α-induced astrocytes...
February 19, 2018: Neurochemical Research
https://www.readbyqxmd.com/read/29460077/orofacial-antinociceptive-effect-of-sulphated-polysaccharide-from-the-marine-algae-hypnea-pseudomusciformis-in-rodents
#19
Caio Átila Prata Bezerra Souza, Breytiner Amaro de Oliveira, Sacha Aubrey Alves Rodrigues Santos, Francisco Lucas Alves Batista, Francisco Regivânio Nascimento Andrade, Eugênio Januário Ramos Neto, José de Maria Albuquerque de Melo Júnior, Francisco Rogenio da Silva Mendes, Lana Karine Vasconcelos Barroso, Kirley Marques Canuto, Francisco Ernani Alves Magalhães, Angelo Roncalli Alves E Silva, Wladimir Ronald Lobo Farias, Adriana Rolim Campos
This study aimed to evaluate the antinociceptive effect of sulphated polysaccharide from the marine algae Hypnea pseudomusciformis (PLS) using rodent models of orofacial pain. Acute pain was induced by formalin, capsaicin, cinnamaldehyde, acidified saline or glutamate (cutaneous modes) and hypertonic saline (corneal model). In one experiment, animals were pretreated with ruthenium red, glibenclamide, naloxone, L-NAME, methylene blue or ketamine to investigate the mechanism of antinociception. In another experiment, animals pretreated with PLS or saline were submitted to the temporomandibular joint formalin test...
February 19, 2018: Inflammopharmacology
https://www.readbyqxmd.com/read/29460009/the-global-spine-care-initiative-applying-evidence-based-guidelines-on-the-non-invasive-management-of-back-and-neck-pain-to-low-and-middle-income-communities
#20
REVIEW
Roger Chou, Pierre Côté, Kristi Randhawa, Paola Torres, Hainan Yu, Margareta Nordin, Eric L Hurwitz, Scott Haldeman, Christine Cedraschi
PURPOSE: The purpose of this review was to develop recommendations for the management of spinal disorders in low-income communities, with a focus on non-invasive pharmacological and non-pharmacological therapies for non-specific low back and neck pain. METHODS: We synthesized two evidence-based clinical practice guidelines for the management of low back and neck pain. Our recommendations considered benefits, harms, quality of evidence, and costs, with attention to feasibility in medically underserved areas and low- and middle-income countries...
February 19, 2018: European Spine Journal
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