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https://www.readbyqxmd.com/read/29691180/multimodal-clinical-pathway-with-adductor-canal-block-decreases-hospital-length-of-stay-improves-pain-control-and-reduces-opioid-consumption-in-total-knee-arthroplasty-patients-a-retrospective-review
#1
Terry A Ellis, Hassan Hammoud, Philip Dela Merced, Nishankkumar P Nooli, Farhad Ghoddoussi, Joshua Kong, Sandeep H Krishnan
BACKGROUND: Total knee arthroplasty volume is increasing significantly in the United States. Reducing hospital length of stay may represent the best method for accommodating expanding volume and reducing costs. We hypothesized that tailoring a clinical pathway to facilitate early ambulation would decrease costs and resource utilization. METHODS: We conducted a sequential before-and-after study of total knee arthroplasty patients after a phased implementation of a clinical pathway that includes multimodal oral analgesic protocols, adductor canal nerve block, and standardized day of surgery ambulation protocols...
March 27, 2018: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29687366/molecular-modeling-of-non-covalent-binding-of-ligustrum-lucidum-secoiridoid-glucosides-to-ap-1-matrix-metalloproteinase-pathway-components
#2
Pathomwat Wongrattanakamon, Piyarat Nimmanpipug, Busaban Sirithunyalug, Wantida Chaiyana, Supat Jiranusornkul
Ligustrum lucidum secoiridoid glucosides have been demonstrated to treat various types of diseases such as inflammation, pain, hepatotoxicity and hyperlipidermic as well as tonic for liver and kidney. Matrix metalloproteinases (MMPs) play a key role upon the pathology of photoaging. The present computational study showed that among the six secoiridoid glucosides (ligustroside, lucidumoside A, lucidumoside C, neonuezhenide, oleoside dimethylester, and oleuropein), ligustroside and lucidumoside A competitively inhibit all MMP-1, MMP-3, and MMP-9 activities in the docking models...
April 23, 2018: Journal of Bioenergetics and Biomembranes
https://www.readbyqxmd.com/read/29687077/efficacy-and-outcomes-of-intrathecal-analgesia-as-part-of-an-enhanced-recovery-pathway-in-colon-and-rectal-surgical-patients
#3
Amit Merchea, Jenna K Lovely, Adam K Jacob, Dorin T Colibaseanu, Scott R Kelley, Kellie L Mathis, Grant M Spears, Marianne Huebner, David W Larson
Purpose: Multimodal analgesia is an essential component of an enhanced recovery pathway (ERP). An ERP that includes the use of single-injection intrathecal analgesia (IA) has been shown to decrease morbidity and cost and shorten length of stay (LOS). Limited data exist on safety, feasibility, and the optimal IA regimen. Our objective was to characterize the efficacy, safety, and feasibility of IA within an ERP in a cohort of colorectal surgical patients. Methods: We performed a retrospective review of all consecutive patients aged ≥ 18 years who underwent open or minimally invasive colorectal surgery from October 2012 to December 2013...
2018: Surgery Research and Practice
https://www.readbyqxmd.com/read/29686989/enhanced-recovery-after-surgery-protocols-in-major-urologic-surgery
#4
REVIEW
Natalija Vukovic, Ljubomir Dinic
The purpose of the review: The analysis of the components of enhanced recovery after surgery (ERAS) protocols in urologic surgery. Recent findings: ERAS protocols has been studied for over 20 years in different surgical procedures, mostly in colorectal surgery. The concept of improving patient care and reducing postoperative complications was also applied to major urologic surgery and especially procedure of radical cystectomy. This procedure is technically challenging, due to a major surgical resection and high postoperative complication rate that may reach 65%...
2018: Frontiers in Medicine
https://www.readbyqxmd.com/read/29686833/natural-products-with-toll-like-receptor-4-antagonist-activity
#5
REVIEW
Monica Molteni, Annalisa Bosi, Carlo Rossetti
Toll-Like Receptors (TLRs) are the innate immunity receptors that play an activating role when interacting with molecules released by bacteria and viruses (PAMPs, pathogen-associated molecular patterns) or with molecules released by injured cells and tissues (DAMPs, danger-associated molecular patterns). TLR triggering leads to the induction of proinflammatory cytokines and chemokines, driving the activation of both innate and adaptive immunity. In particular, Toll-Like Receptor 4 (TLR4) has been described to be involved in the inflammatory processes observed in several pathologies (such as ischemia/reperfusion injury, neuropathic pain, neurodegenerative diseases, and cancer)...
2018: International Journal of Inflammation
https://www.readbyqxmd.com/read/29686303/mitochondrial-dna-induces-foley-catheter-related-bladder-inflammation-via-toll-like-receptor-9-activation
#6
Carlos A Puyo, Alexander Earhart, Nicholas Staten, Yuan Huang, Alana Desai, Henry Lai, Ramakrishna Venkatesh
Bladder instrumentation engages the innate immune system via neutrophil activation, promoting inflammation and pain. Elevated levels of mitochondrial DNA (mtDNA) have been associated with tissue damage and organ dysfunction. We hypothesized that local bladder trauma induced by a Foley catheter (FC) will result in mtDNA release, migration of neutrophils into the bladder lumen, and activation of the Toll-like receptor 9 (TLR9) and nuclear factor kappa B (NF-κB) pathway leading to bladder tissue damage. We randomized 10 swine into two groups receiving uncoated, or chloroquine/N-Acetylcysteine (CQ/NAC)-coated FCs...
April 23, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29685141/sinew-acupuncture-for-knee-osteoarthritis-study-protocol-for-a-randomized-sham-controlled-trial
#7
Kwok Yin Au, Haiyong Chen, Wing Chung Lam, Chiu On Chong, Andrew Lau, Varut Vardhanabhuti, Kin Cheung Mak, Fei Jiang, Wing Yi Lam, Fung Man Wu, Hiu Ngok Chan, Yan Wah Ng, Bacon Fung-Leung Ng, Eric Tat-Chi Ziea, Lixing Lao
BACKGROUND: Sinew acupuncture is a new modality of acupuncture in which needles are inserted into acupoints, ashi points or spasm points of sinew and muscles along the meridian sinew pathway. A previous observational study revealed that sinew acupuncture has immediate analgesic effects on various soft tissue injuries, including knee injuries. However, no rigorous trials have been conducted. This study aims to examine whether sinew acupuncture can safely relieve pain and symptoms of knee osteoarthritis (KOA) and improve patients' functional movement and quality of life...
April 23, 2018: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29684652/generosity-and-compliance-recruitment-work-and-the-pathways-to-participation-in-bone-marrow-donation
#8
Kushan Dasgupta
This study examines challenges involved in recruiting bone marrow donors. Data comes from participant observation with a recruitment organization in the United States. Findings reveal that recruiters try to express bone marrow donation with common "gift of life" messaging, which emphasizes a singular event involving generosity. Potential recruits, however, respond by focusing on pain and time commitments. These concerns draw attention to the many stages and requirements involved in bone marrow donation and make issues of compliance salient...
April 12, 2018: Social Science & Medicine
https://www.readbyqxmd.com/read/29681797/electroacupuncture-potentiates-cannabinoid-receptor-mediated-descending-inhibitory-control-in-a-mouse-model-of-knee-osteoarthritis
#9
Xiao-Cui Yuan, Bing Zhu, Xiang-Hong Jing, Li-Ze Xiong, Cai-Hua Wu, Fang Gao, Hong-Ping Li, Hong-Chun Xiang, He Zhu, Bin Zhou, Wei He, Chuan-You Lin, Hui-Lin Pan, Qiang Wang, Man Li
Knee osteoarthritis (KOA) is a highly prevalent, chronic joint disorder, which can lead to chronic pain. Although electroacupuncture (EA) is effective in relieving chronic pain in the clinic, the involved mechanisms remain unclear. Reduced diffuse noxius inhibitory controls (DNIC) function is associated with chronic pain and may be related to the action of endocannabinoids. In the present study, we determined whether EA may potentiate cannabinoid receptor-mediated descending inhibitory control and inhibit chronic pain in a mouse model of KOA...
2018: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/29681195/biologics-for-treating-axial-spondyloarthritis
#10
Alexis Jones, Coziana Ciurtin, Mediola Ismajli, Maria Leandro, Raj Sengupta, Pedro M Machado
Spondyloarthritis (SpA) encompasses a heterogeneous group of diseases sharing genetic, immunological, clinical and imaging features. Axial spondyloarthritis (axSpA) refers to a subgroup characterised predominately by inflammation of the axial skeleton with subsequent symptoms of chronic (often inflammatory) back pain and sacroiliitis. There is a strong association with the major histocompatibility complex (MHC) class I allele human leukocyte antigen (HLA) B27. In the last decade, there has been significant progress in earlier detection of the disease and the molecular mechanisms involved in its pathogenesis...
April 21, 2018: Expert Opinion on Biological Therapy
https://www.readbyqxmd.com/read/29680841/differential-metallothionein-expression-in-oral-lichen-planus-and-amalgam-associated-oral-lichenoid-lesions
#11
G-G Mendes, J-P-S Servato, F-C Borges, R-R Rosa, C-S Siqueira, P-R de Faria, A-M Loyola, S-V Cardoso
BACKGROUND: Oral lichen planus (OLP) is a chronic inflammatory disease mediated by T cells, which manifests as reticular (white) or erosive (red) lesions, that are eventually painful. Oral lichenoid lesion (OLL) are distinguished from OLP by the presence of precipitating factors. The aim of this study was to evaluate whether the presence of metallothionein, which is involved in anti-apoptotic pathways and the anti-oxidative response, could serve as a differential diagnostic for OLP and OLL...
April 22, 2018: Medicina Oral, Patología Oral y Cirugía Bucal
https://www.readbyqxmd.com/read/29680815/patient-trajectories-and-their-impact-on-mobility-social-participation-and-quality-of-life-in-patients-with-vertigo-dizziness-balance-disorders-and-osteoarthritis-mobile-tra-study-protocol-of-an-observational-practice-based-cohort-study
#12
Rebecca Kisch, Antje Bergmann, Daniela Koller, Reiner Leidl, Ulrich Mansmann, Martin Mueller, Linda Sanftenberg, Joerg Schelling, Leonie Sundmacher, Karen Voigt, Eva Grill
INTRODUCTION: Mobility limitations have a multitude of different negative consequences on elderly patients including decreasing opportunities for social participation, increasing the risk for morbidity and mortality. However, current healthcare has several shortcomings regarding mobility sustainment of older adults, namely a narrow focus on the underlying pathology, fragmentation of care across services and health professions and deficiencies in personalising care based on patients' needs and experiences...
April 21, 2018: BMJ Open
https://www.readbyqxmd.com/read/29680740/moringa-concanensis-nimmo-ameliorates-hyperglycemia-in-3t3-l1-adipocytes-by-upregulating-ppar-%C3%AE-c-ebp-%C3%AE-via-akt-signaling-pathway-and-stz-induced-diabetic-rats
#13
Brindha Banu Balakrishnan, Kalaivani Krishnasamy, Ki Choon Choi
Moringa concanensis Nimmo is a medicinal plant for treating various human illnesses including menstrual pain, high blood pressure, jaundice, inflammation, pain, fever, sore eyes, and cholesterol in Indian folk medicine. Despite its versatility, its antihyperglycemic mechanism of action (in vitro and in vivo) remains unclear. Therefore, in this study we developed the possible antihyperglycemic mechanism of action in 3T3-L1 cells by evaluating mRNA and protein expression, which are associated with adipogenesis and lipogenesis (insulin sensitizer)...
April 19, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29679681/inhibition-of-protein-kinase-a-and-girk-channel-reverses-fentanyl-induced-respiratory-depression
#14
Xiaonan Liang, Zheng Yong, Ruibin Su
Opioid-induced respiratory depression is a major obstacle to improving the clinical management of moderate to severe chronic pain. Opioids inhibit neuronal activity via various pathways, including calcium channels, adenylyl cyclase, and potassium channels. Currently, the underlying molecular pathway of opioid-induced respiratory depression is only partially understood. This study aimed to investigate the mechanisms of opioid-induced respiratory depression in vivo by examining the effects of different pharmacological agents on fentanyl-induced respiratory depression...
April 18, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29679037/the-therapeutic-potential-and-molecular-mechanism-of-isoflavone-extract-against-psoriasis
#15
Hsin-Ju Li, Nan-Lin Wu, Gon-Ann Lee, Chi-Feng Hung
Psoriasis is a common inflammatory disease. It affects 1-3% of the population worldwide and is associated with increasing medical costs every year. Typical psoriatic skin lesions are reddish, thick, scaly plaques that can occur on multiple skin sites all over the body. Topical application of imiquimod (IMQ), a toll-like receptor (TLR)7 agonist and potent immune system activator, can induce and exacerbate psoriasis. Previous studies have demonstrated that isoflavone extract has an antioxidant effect which may help decrease inflammation and inflammatory pain...
April 20, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29678719/carnosic-acid-attenuates-cartilage-degeneration-through-induction-of-heme-oxygenase-1-in-human-articular-chondrocytes
#16
Hiroyuki Ishitobi, Yohei Sanada, Yoshio Kato, Yasunari Ikuta, Sachi Shibata, Satoshi Yamasaki, Martin K Lotz, Kiminori Matsubara, Shigeru Miyaki, Nobuo Adachi
Osteoarthritis (OA) is common age-associated disease, and associated with joint pain, mobility limitations and compromised overall quality of life. OA treatment is currently limited to pain management and joint arthroplasty at end stage disease. Oxidative damage to cartilage extracellular matrix and cells is an important mechanism in joint aging and OA pathogenesis. Evidence from in vitro and in vivo models of OA suggests that pharmaceuticals and natural compounds with antioxidant properties reduce expression of mediators of OA pathogenesis and OA severity in animal models...
April 17, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29678208/glial-interleukin-1%C3%AE-upregulates-neuronal-sodium-channel-1-7-in-trigeminal-ganglion-contributing-to-temporomandibular-joint-inflammatory-hypernociception-in-rats
#17
Peng Zhang, Rui-Yun Bi, Ye-Hua Gan
BACKGROUND: The proinflammatory cytokine interleukin-1β (IL-1β) drives pain by inducing the expression of inflammatory mediators; however, its ability to regulate sodium channel 1.7 (Nav1.7), a key driver of temporomandibular joint (TMJ) hypernociception, remains unknown. IL-1β induces cyclooxygenase-2 (COX-2) and prostaglandin E2 (PGE2). We previously showed that PGE2 upregulated trigeminal ganglionic Nav1.7 expression. Satellite glial cells (SGCs) involve in inflammatory pain through glial cytokines...
April 20, 2018: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29675890/the-prevalence-and-potential-determinants-of-dysmenorrhoea-and-other-pelvic-pain-in-women-a-prospective-study
#18
Antoinette Righarts, Lauren Osborne, Jennie Connor, Wayne Gillett
OBJECTIVE: To estimate the prevalence of pelvic pain, and model associations with potential demographic, obstetric, gynaecological, and psychosocial determinants. DESIGN, SETTING AND SAMPLE: A cohort study of women born between 1972-1973 in Dunedin, New Zealand, most recently assessed when aged 38 years (95% of survivors retained); 429 women were eligible for analysis. METHODS: Women self-completed reproductive health questionnaires at ages 21, 26, 32 and 38 years, with questions on dysmenorrhoea at ages 13 and 15, and on all pelvic pain at age 38...
April 19, 2018: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29675582/multifunctional-opioid-ligands
#19
Jessica P Anand, Deanna Montgomery
The opioid receptor system plays a major role in the regulation of mood, reward, and pain. The opioid receptors therefore make attractive targets for the treatment of many different conditions, including pain, depression, and addiction. However, stimulation or blockade of any one opioid receptor type often leads to on-target adverse effects that limit the clinical utility of a selective opioid agonist or antagonist. Literature precedent suggests that the opioid receptors do not act in isolation and that interactions among the opioid receptors and between the opioid receptors and other proteins may produce clinically useful targets...
April 20, 2018: Handbook of Experimental Pharmacology
https://www.readbyqxmd.com/read/29674959/meal-sensing-signaling-pathways-in-functional-dyspepsia
#20
REVIEW
Amanda J Page, Hui Li
The upper gastrointestinal tract plays an important role in sensing the arrival, amount and chemical composition of a meal. Ingestion of a meal triggers a number of sensory signals in the gastrointestinal tract. These include the response to mechanical stimulation (e.g., gastric distension), from the presence of food in the gut, and the interaction of various dietary nutrients with specific "taste" receptors on specialized enteroendocrine cells in the small intestine culminating in the release of gut hormones...
2018: Frontiers in Systems Neuroscience
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