keyword
https://read.qxmd.com/read/38307456/safety-and-efficacy-of-insulins-in-critically-ill-patients-receiving-continuous-enteral-nutrition
#21
JOURNAL ARTICLE
Kevin Ni, R Matthew Hawkins, Heather L Smyth, Stacey A Seggelke, Joanna Gibbs, Mark C Lindsay, Laura K Kaizer, Cecilia C Low Wang
OBJECTIVE: There is a relative lack of consensus regarding the optimal management of hyperglycemia in patients receiving continuous enteral nutrition (EN), with or without a diagnosis of diabetes. METHODS: This retrospective study examined 475 patients (303 with known diabetes) hospitalized in critical-care setting units in 2019 in a single center who received continuous EN. Rates of hypoglycemia, hyperglycemia, and glucoses within target range (70-180 mg/dL) were compared in those with or without diabetes, and treated with intermediate acting (IA) biphasic neutral protamine Hagedorn (NPH) 70/30 or long-acting (LA) or rapid-acting (RA) only insulin...
January 31, 2024: Endocrine Practice
https://read.qxmd.com/read/38307227/predictors-of-occlusion-after-carotid-stenting
#22
JOURNAL ARTICLE
Paul Rothenberg, Santiago Joaquin Lopez, Dylan Thibault, Lakshmikumar Pillai, Samantha Danielle Minc
OBJECTIVE: Carotid artery stent (CAS) occlusion is a rare complication not well studied. We used a national dataset to assess real world CAS experience to determine the rate of stent occlusion. The purpose of this study was to: 1) Identify risk factors associated with CAS occlusion on long-term follow-up (LTFU) and 2) Determine the adjusted odds of death/transient ischemic attack (TIA)/stroke (CVA) in patients with occlusion. METHODS: The national VQI CAS dataset (2016-2021) comprised the sample...
January 31, 2024: Annals of Vascular Surgery
https://read.qxmd.com/read/38294949/effect-of-penetration-enhancer-on-the-structure-of-stratum-corneum-on-site-study-by-confocal-polarized-raman-imaging
#23
JOURNAL ARTICLE
Feng Zhong, Hangwei Lu, Ru Meng, Chunbo Feng, Haidong Jia, Hai-Feng Yang, Feng Wang
Keratin and lipid structures in the stratum corneum (SC) are closely related to the SC barrier function. The application of penetration enhancers (PEs) disrupts the structure of SC, thereby promoting infiltration. To quantify these PE-induced structural changes in SC, we used confocal Raman imaging (CRI) and polarized Raman imaging (PRI) to explore the integrity and continuity of keratin and lipid structures in SC. The results showed that water is the safest PE and that oleic acid (OA), sodium dodecyl sulfate (SDS), and low molecular weight protamine (LMWP) disrupted the ordered structure of keratin, while azone and liposomes had less of an effect on keratin...
January 31, 2024: Molecular Pharmaceutics
https://read.qxmd.com/read/38291667/real-time-detection-of-circulating-thrombi-in-an-extracorporeal-circuit-using-doppler-ultrasound-in-vitro-proof-of-concept-study
#24
JOURNAL ARTICLE
Syed Murfad Peer, Manan Desai, Syed Bukhari, Yunchuan Delores, Richard Jonas, Pranava Sinha
BACKGROUND: Thromboembolic stroke continues to be by far the most common severe adverse event in patients supported with mechanical circulatory assist devices. Feasibility of using Doppler ultrasound to detect circulating thrombi in an extracorporeal circuit was investigated. METHODS: A mock extracorporeal circulatory loop of uncoated cardiopulmonary bypass tubing and a roller pump was setup. A Doppler bubble counter was used to monitor the mean ultrasound backscatter signal (MUBS)...
January 30, 2024: World Journal for Pediatric & Congenital Heart Surgery
https://read.qxmd.com/read/38289201/sperm-dna-fragmentation-causes-evaluation-and-management-in-male-infertility
#25
REVIEW
Syed Waseem Andrabi, Anam Ara, Ankur Saharan, Mir Jaffar, Nivita Gugnani, Sandro C Esteves
Male infertility is a great matter of concern as out of 15% of infertile couples in the reproductive age, about 40% are contributed by male factors alone. For DNA condensation during spermatogenesis, constrained DNA nicking is required, which if increased beyond certain level results in infertility in men. High sperm DNA Fragmentation (SDF) majorly contributes to male infertility and its association with regards to poor natural conception and assisted reproductive technology (ART) outcomes is equivocal. Apoptosis, protamination failure and the excess of reactive oxygen species (ROS) are considered to be the main causes of SDF...
January 30, 2024: JBRA Assisted Reproduction
https://read.qxmd.com/read/38270666/association-between-intraoperative-blood-salvage-and-coagulation-disorder-after-cardiopulmonary-bypass
#26
JOURNAL ARTICLE
Masahiro Morinaga, Kenji Yoshitani, Soshiro Ogata, Satsuki Fukushima, Hitoshi Matsuda
BACKGROUND: This study investigated whether intraoperative blood salvage was associated with coagulation disorder diagnosed by conventional coagulation tests and thromboelastography (TEG) after cardiopulmonary bypass (CPB). STUDY DESIGN AND METHODS: This was a prospective, observational study. Ninety-two patients who underwent cardiovascular surgery with CPB were enrolled. We evaluated coagulation function in patients with or without cell salvage blood transfusion at the following time points: before CPB, just after protamine administration, and 1 h after protamine administration...
January 25, 2024: JA Clinical Reports
https://read.qxmd.com/read/38268214/ameliorative-effect-of-crocin-on-post-thaw-quality-fertility-associated-gene-expression-and-fertilization-potential-of-buffalo-bubalus-bubalis-bull-sperm
#27
JOURNAL ARTICLE
Ghulam Shabbir Khan, Muhammad Zahid Tahir, Muhammad Yasir Zahoor, Hifz-Ul- Rahman, Amjad Riaz
Buffalo bull sperm suffer more cryoinjuries due to lipid peroxidation of high structural polyunsaturated fatty acid contents than cattle sperm. Consequently, the post-thaw fertilization potential of buffalo bull sperm is compromised. Crocin is a carotenoid known for its antioxidant potential through scavenging reactive oxygen species. Objectives of the current study were to investigate the effect of crocin addition in the semen extender on post-thaw quality, fertility-associated gene expression and fertilization potential of buffalo bull sperm...
January 2024: Reproduction in Domestic Animals
https://read.qxmd.com/read/38264767/protamine-dosing-and-its-impact-in-cardiac-surgery-transfusion-practice-a-retrospective-bi-institutional-analysis
#28
JOURNAL ARTICLE
Samhati Mondal, Ezeldeen Abuelkasem, Roumen Vesselinov, Reney Henderson, Seung Choi, Ahmad Mousa, Khaled J Zaza, Kenichi A Tanaka
BACKGROUND: Bleeding after cardiac surgery is common and continues to require 10-20% of the national blood supply. Transfusion of allogeneic blood is associated with increased morbidity and mortality. Excessive protamine in the absence of circulating heparin after weaning off CPB can cause anticoagulation and precipitate bleeding. Hence, adequate dose calculation of protamine is crucial yet under evaluated. STUDY DESIGN: Retrospective cohort study. METHODS: We conducted a retrospective bi-institutional analysis of cardiac surgical patients who underwent cardiopulmonary bypass (CPB)-assisted cardiac surgery to assess the impact of protamine dosing in transfusion practice...
January 24, 2024: Transfusion
https://read.qxmd.com/read/38262054/immune-stealth-vp28-conjugated-heparin-nanoparticles-for-enhanced-and-reversible-anticoagulation
#29
JOURNAL ARTICLE
Hussein Reda Hussein, Chia-Yu Chang, Yini Zheng, Chih-Yu Yang, Li-Hua Li, Yi-Tzu Lee, Jun-Yi Chen, Yu-Chaun Liang, Chuan-Ju Lin, Yu-Chia Chang, Hui Nee Geo, Suzita Mohd Noor, Lik Voon Kiew, Fu-Rong Chen, Chia-Ching Chang
Heparins are a family of sulfated linear negatively charged polysaccharides that have been widely used for their anticoagulant, antithrombotic, antitumor, anti-inflammatory, and antiviral properties. Additionally, it has been used for acute cerebral infarction relief as well as other pharmacological actions. However, heparins self-aggregated macrocomplex may reduce blood circulation time and induce life-threatening thrombocytopenia (HIT) complicating the use of heparins. Nonetheless, the conjugation of heparin to immuno-stealth biomolecules may overcome these obstacles...
January 23, 2024: Nanotechnology
https://read.qxmd.com/read/38255792/reduced-sirt1-and-sirt3-and-lower-antioxidant-capacity-of-seminal-plasma-is-associated-with-shorter-sperm-telomere-length-in-oligospermic-men
#30
JOURNAL ARTICLE
Varinderpal S Dhillon, Mohammad Shahid, Permal Deo, Michael Fenech
Infertility affects millions of couples worldwide and has a profound impact not only on their families, but also on communities. Telomere attrition has been associated with infertility, DNA damage and fragmentation. Oxidative stress has been shown to affect sperm DNA integrity and telomere length. Sirtuins such as SIRT1 and SIRT3 are involved in aging and oxidative stress response. The aim of the present study is to determine the role of SIRT1 and SIRT3 in regulating oxidative stress, telomere shortening, and their association with oligospermia...
January 5, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38243211/small-noncoding-rnas-and-sperm-nuclear-basic-proteins-reflect-the-environmental-impact-on-germ-cells
#31
JOURNAL ARTICLE
Giulio Ferrero, Rosaria Festa, Laura Follia, Gennaro Lettieri, Sonia Tarallo, Tiziana Notari, Antonella Giarra, Carmela Marinaro, Barbara Pardini, Alessandra Marano, Giulia Piaggeschi, Carla Di Battista, Marco Trifuoggi, Marina Piscopo, Luigi Montano, Alessio Naccarati
BACKGROUND: Molecular techniques can complement conventional spermiogram analyses to provide new information on the fertilizing potential of spermatozoa and to identify early alterations due to environmental pollution. METHODS: Here, we present a multilevel molecular profiling by small RNA sequencing and sperm nuclear basic protein analysis of male germ cells from 33 healthy young subjects residing in low and high-polluted areas. RESULTS: Although sperm motility and sperm concentration were comparable between samples from the two sites, those from the high-pollution area had a higher concentration of immature/immune cells, a lower protamine/histone ratio, a reduced ability of sperm nuclear basic proteins to protect DNA from oxidative damage, and an altered copper/zinc ratio in sperm...
January 20, 2024: Molecular Medicine
https://read.qxmd.com/read/38202846/isolation-and-purification-of-protamine-from-the-cultured-takifugu-flavidus-and-its-physicochemical-properties
#32
JOURNAL ARTICLE
Shuji Liu, Yue Zhang, Yihui Chen, Yongchang Su, Bei Chen, Yin Wang, Min Xu, Kun Qiao, Shuigen Li, Zhiyu Liu
Protamine is a cationic peptide derived from fish sperm and has several important functional properties: antibacterial properties, acting as a carrier for injectable insulin and as a heparin antagonist, combatting fatigue, etc. Thus, it has been widely used in medicinal applications and food products. Cultured Takifugu flavidus is a type of pufferfish with a delicious taste that is popular in China, and its production is increasing significantly. Therefore, protamine was extracted via acid extraction from the sperm of Takifugu flavidus and further isolated and purified via sephadex gel chromatography, ion exchange chromatography, and desalination chromatography...
January 4, 2024: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/38193053/reassessment-of-dextran-sulfate-in-anti-xa-assay-for-unfractionated-heparin-laboratory-monitoring
#33
JOURNAL ARTICLE
Michael Hardy, Julien Cabo, Antoine Deliège, Jonathan Douxfils, Isabelle Gouin-Thibault, Thomas Lecompte, François Mullier
BACKGROUND: Anti-Xa assays are used for unfractionated heparin (UFH) monitoring. Dextran sulfate (DS) is used in some assays to overcome the artifactual preanalytical release of platelet factor 4. However, the practical implications of this test modification have not been studied extensively. OBJECTIVES: To investigate the impact of the presence of DS in the anti-Xa assay for UFH laboratory monitoring. METHODS: We studied factor Xa inhibition, using an assay without DS (Stago Liquid Anti-Xa), in normal pool plasma spiked with various concentrations of UFH (up to 1 IU/mL) in the presence of increasing concentrations of DS (up to 2560 μg/mL)...
November 2023: Research and Practice in Thrombosis and Haemostasis
https://read.qxmd.com/read/38170186/molecular-and-functional-characterization-of-human-sex-determining-region-on-the-y-chromosome-variants-using-protamine-1-promoter
#34
JOURNAL ARTICLE
Deepali Pathak, Arka Baksi, S S Vasan, Rajan R Dighe
The male sex-determining gene, sex-determining region on the Y chromosome ( SRY ), is expressed in adult testicular germ cells; however, its role in regulating spermatogenesis remains unclear. The role of SRY in the postmeiotic gene expression was investigated by determining the effect of SRY on the promoter of the haploid-specific Protamine 1 ( PRM1 ) gene, which harbors five distinct SRY -binding motifs. In a luciferase reporter assay system, SRY upregulates PRM1 promoter activity in vitro in a dose-dependent manner...
January 3, 2024: DNA and Cell Biology
https://read.qxmd.com/read/38163951/prevention-and-treatment-of-pericardial-tamponade-in-the-electrophysiology-laboratory-a-european-heart-rhythm-association-survey
#35
JOURNAL ARTICLE
Andreas Metzner, Arian Sultan, Piotr Futyma, Sergio Richter, Laura Perrotta, K R Julian Chun
AIMS: Pericardial tamponade (PT) is the most frequent severe complication during electrophysiology (EP) procedures and requires immediate, co-ordinated, and effective treatment. However, multiple aspects of PT treatment are either not standardized or are under ongoing debate. METHODS AND RESULTS: An online questionnaire consisting of 26 multiple-choice questions was sent out to the European Heart Rhythm (EHRA) Research Network and also distributed via social media outputs...
December 28, 2023: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://read.qxmd.com/read/38160236/real-world-analysis-of-long-acting-and-nph-containing-insulins-on-glycemic-control
#36
JOURNAL ARTICLE
Genevieve Hale, Valerie Marcellus, Tina Benny, Cynthia Moreau, Elaina Rosario, Alexandra Perez
Introduction Affordability of insulin products has become a concern in the past several years as the average price of various insulin products has increased. While awaiting legislation at the federal level that would address issues leading to high insulin costs, providers may have shifted prescribing practices to prescribe the lowest-priced insulin products to achieve patients' treatment goals. Objective To compare the prevalence of hypoglycemic events between patients receiving lower-cost neutral protamine Hagedorn (NPH)-containing human insulins and higher-cost long-acting insulin analogs in Medicare Part D enrollees within a management services organization, as well as assessing glycemic control and changes in body mass index...
January 1, 2024: Senior Care Pharmacist
https://read.qxmd.com/read/38152658/dual-basal-insulin-regimen-for-the-management-of-dawn-phenomenon-in-children-with-type-1-diabetes-a-retrospective-cohort-study
#37
JOURNAL ARTICLE
Nur Berna Celik, Dicle Canoruc Emet, Merve Canturk, Z Alev Ozon, E Nazli Gonc
BACKGROUND: Handling of the dawn phenomenon (DP) with multiple daily insulin injection (MDII) regimen is a real challenge. OBJECTIVE: We aimed to demonstrate the effectiveness of a dual-basal-insulin (a long-acting glargine and an intermediate-acting neutral protamine Hagedorn (NPH)) regimen for the management of DP in children with type 1 diabetes mellitus (T1DM). The primary efficacy outcome was to overcome morning hyperglycemia without causing hypoglycemia during the non-DP period of the night...
2023: Therapeutic Advances in Endocrinology and Metabolism
https://read.qxmd.com/read/38152205/three-step-surgical-management-algorithm-for-annular-rupture-in-transcatheter-aortic-valve-replacement
#38
JOURNAL ARTICLE
Kizuku Yamashita, Kazuo Shimamura, Koichi Maeda, Ai Kawamura, Masaki Taira, Daisuke Yoshioka, Shigeru Miyagawa
OBJECTIVE: Whereas transcatheter aortic valve replacement is widely implemented, annular rupture is a devastating complication and could be highly mortal. However, owing to its rare incidence, the optimal treatment algorithm has not been established. Thus, we evaluated the feasibility and effectiveness of a 3-step algorithm to treat annulus rupture. METHODS: From 2009 to 2022, 8 patients of 1083 transcatheter aortic valve implantation (0.8%) developed annulus rupture and were treated with the three-step algorithm...
December 2023: JTCVS techniques
https://read.qxmd.com/read/38149503/caco-3-nanoparticles-delivering-microrna-200c-suppress-oral-squamous-cell-carcinoma
#39
JOURNAL ARTICLE
Q J Ding, M T Remy, C Upara, J Hu, A V Mora Mata, A J Haes, E Lanzel, H Sun, M R Buchakjian, L Hong
MicroRNA (miR)-200c suppresses the initiation and progression of oral squamous cell carcinoma (OSCC), the most prevalent head and neck cancer with high recurrence, metastasis, and mortality rates. However, miR-200c -based gene therapy to inhibit OSCC growth has yet to be reported. To develop an miR-based gene therapy to improve the outcomes of OSCC treatment, this study investigates the feasibility of plasmid DNA (pDNA) encoding miR-200c delivered via nonviral CaCO3 -based nanoparticles to inhibit OSCC tumor growth...
December 27, 2023: Journal of Dental Research
https://read.qxmd.com/read/38142472/protamine-2-and-phospholipase-c-zeta-1-are-possible-biomarkers-for-the-diagnosis-of-male-subfertility-in-frozen-thawed-stallion-semen
#40
JOURNAL ARTICLE
Veronica Vigolo, Camille Gautier, Reinhard Ertl, Christine Aurich, Maria Elena Falomo
Subfertility is one of the main issues in horse breeding and the study of mRNAs in sperm might help in elucidating the reasons that lead to this diagnosis. The present study aims at assessing the differences in the expression of 10 potential candidate genes in stallions of different fertility. Frozen-thawed semen of 29 stallions was included. Each sample was classified into two groups according to pregnancy rates (PR) achieved with this semen: "good fertility" (GF; n = 17; PR ≥ 30 %) or "poor fertility" (PF; n = 12; PR <20 %)...
December 12, 2023: Theriogenology
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