Zahra Darmishonnejad, Vahideh Hassan Zadeh, Marziyeh Tavalaee, Farzad Kobarfard, Mahsa Hassani, Parviz Gharagozloo, Joël R Drevet, Mohammad Hossein Nasr-Esfahani
This study investigated the deleterious impact of advanced glycation end products (AGEs), commonly present in metabolic disorders like diabetes, obesity, and infertility-related conditions, on sperm structure and function using a mouse model where AGE generation was heightened through dietary intervention. Five-week-old C57BL/6 mice were divided into two groups, one on a regular diet (control) and the other on an AGE-rich diet. After 13 weeks, various parameters were examined, including fasting blood glucose, body weight, food consumption, sperm parameters and function, testicular superoxide dismutase levels, malondialdehyde content, total antioxidant capacity, Johnson score, AGE receptor (RAGE) content, and carboxymethyl lysine (CML) content...
March 13, 2024: Reproductive Sciences