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https://www.readbyqxmd.com/read/27445681/ghosts-in-the-machine-interoceptive-modeling-for-chronic-pain-treatment
#1
Daniele Di Lernia, Silvia Serino, Pietro Cipresso, Giuseppe Riva
Pain is a complex and multidimensional perception, embodied in our daily experiences through interoceptive appraisal processes. The article reviews the recent literature about interoception along with predictive coding theories and tries to explain a missing link between the sense of the physiological condition of the entire body and the perception of pain in chronic conditions, which are characterized by interoceptive deficits. Understanding chronic pain from an interoceptive point of view allows us to better comprehend the multidimensional nature of this specific organic information, integrating the input of several sources from Gifford's Mature Organism Model to Melzack's neuromatrix...
2016: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/27088014/the-gate-theory-of-pain-revisited-modeling-different-pain-conditions-with-a-parsimonious-neurocomputational-model
#2
Francisco Javier Ropero Peláez, Shirley Taniguchi
The gate control theory of pain proposed by Melzack and Wall in 1965 is revisited through two mechanisms of neuronal regulation: NMDA synaptic plasticity and intrinsic plasticity. The Melzack and Wall circuit was slightly modified by using strictly excitatory nociceptive afferents (in the original arrangement, nociceptive afferents were considered excitatory when they project to central transmission neurons and inhibitory when projecting to substantia gelatinosa). The results of our neurocomputational model are consistent with biological ones in that nociceptive signals are blocked on their way to the brain every time a tactile stimulus is given at the same locus where the pain was produced...
2016: Neural Plasticity
https://www.readbyqxmd.com/read/27080365/provoked-vestibulodynia-does-pain-intensity-correlate-with-sexual-dysfunction-and-dissatisfaction
#3
Leen Aerts, Sophie Bergeron, Caroline F Pukall, Samir Khalifé
INTRODUCTION: Provoked vestibulodynia (PVD) is suspected to be the most frequent cause of vulvodynia in premenopausal women. Previous research has been inconclusive as to whether higher vulvovaginal pain ratings are associated with lower sexual function and satisfaction in women with PVD. Whether pain intensity correlates with sexual impairment is an important question given its implications for treatment recommendations. AIM: To examine the associations among self-reported and objective pain measurements, sexual function, and sexual satisfaction in a large combined clinical and community sample of premenopausal women diagnosed with PVD...
June 2016: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/26898050/psychological-factors-in-experience-of-pain-during-childbirth
#4
Ana Havelka Mestrović, Morana Bilić, Larisa Buhin Loncar, Vlatko Micković, Zoran Loncar
Pain during delivery is unique because it is accompanied by powerful emotions. Emotions that occur in women during labor and delivery are closely tied to upbringing and culture in which they were raised and consequently with the sensation of experienced pain. According to the Melzack-Wall Theory of Pain, general mood is directly related to the intensity and quality of pain and it is therefore justifiable to presuppose that certain psychosocial factors will be linked with the intensity and quality of pain experienced during childbirth...
September 2015: Collegium Antropologicum
https://www.readbyqxmd.com/read/26849276/enigma-of-painful-diabetic-neuropathy-can-we-use-the-basic-science-research-outcomes-and-real-world-data-to-help-improve-patient-care-and-outcomes
#5
D V Coppini
The basic mechanisms responsible for painful neuropathy are threefold: peripheral sensory nerve hyper-excitability; central sensitization and defects in central inhibitory pathways (Fig. 1). On a more cellular and molecular level, the aetiological postulations become more complex, however, and various mechanisms occurring at spinal cord level are implicated. The N-methyl-D-aspartate (NMDA) receptor in the spinal cord has been intensively studied, has a key role in relaying painful stimuli from peripheral nerves to higher centres [1], and forms the basis of the revolving gate theory first described by Melzack and Wall 50 years ago [2]...
February 5, 2016: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/26817644/gain-control-mechanisms-in-the-nociceptive-system
#6
Rolf-Detlef Treede
The "gate control theory of pain" of 1965 became famous for integrating clinical observations and the understanding of spinal dorsal horn circuitry at that time into a testable model. Although it became rapidly clear that spinal circuitry is much more complex than that proposed by Melzack and Wall, their prediction of the clinical efficacy of transcutaneous electrical nerve stimulation and spinal cord stimulation has left an important clinical legacy also 50 years later. In the meantime, it has been recognized that the sensitivity of the nociceptive system can be decreased or increased and that this "gain control" can occur at peripheral, spinal, and supraspinal levels...
June 2016: Pain
https://www.readbyqxmd.com/read/26755090/why-us-perceived-injustice-is-associated-with-more-sexual-and-psychological-distress-in-couples-coping-with-genito-pelvic-pain
#7
Myriam Pâquet, Katy Bois, Natalie O Rosen, Marie-Hélène Mayrand, Véronique Charbonneau-Lefebvre, Sophie Bergeron
INTRODUCTION: Provoked vestibulodynia (PVD) is the most frequent cause of genito-pelvic pain/penetration disorder (GPPPD) and is associated with negative psychological and sexual consequences for affected women and their partners. PVD is often misdiagnosed or ignored and many couples may experience a sense of injustice, due to the loss of their ability to have a normal sexual life. Perceiving injustice has been documented to have important consequences in individuals with chronic pain...
January 2016: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/26642069/the-golden-anniversary-of-melzack-and-wall-s-gate-control-theory-of-pain-celebrating-50-years-of-pain-research-and-management
#8
Joel Katz, Brittany N Rosenbloom
No abstract text is available yet for this article.
November 2015: Pain Research & Management: the Journal of the Canadian Pain Society
https://www.readbyqxmd.com/read/26304172/pain
#9
Ronald Melzack, Joel Katz
Pain has many valuable functions. It often signals injury or disease, generates a wide range of adaptive behaviors, and promotes healing through rest. Despite these beneficial aspects of pain, there are negative features that challenge our understanding of the puzzle of pain, including persistent phantom limb pain after amputation or total spinal cord transection. Pain is a personal, subjective experience influenced by cultural learning, the meaning of the situation, attention, and other psychological variables...
January 2013: Wiley Interdisciplinary Reviews. Cognitive Science
https://www.readbyqxmd.com/read/26299052/-the-neuromatrix-and-its-importance-in-pain-neurobiology
#10
EDITORIAL
Ricardo Cárdenas Fernández
The gate control theory of pain, introduced by Melzack and Wall in 1965, led the way in pain research during the second half of the 20th century. Eventually, the observation of pain-related phenomena which the theory could not satisfactorily explain propelled Melzack to develop a new concept, the neuromatrix, which considers as participants in the pain transmission and modulation system, certain brain areas not traditionally associated with the pain experience. This concept places equal importance on the sensory, affective and cognitive aspects of pain, helping the advancement of novel diagnostic and therapeutic approaches in different clinical pain conditions...
June 2015: Investigación Clínica
https://www.readbyqxmd.com/read/26156269/effectiveness-of-new-vibration-delivery-system-on-pain-associated-with-injection-of-local-anesthesia-in-children
#11
Mangalampally Shilpapriya, Mungara Jayanthi, Venumbaka Nilaya Reddy, Rajendran Sakthivel, Girija Selvaraju, Poornima Vijayakumar
AIM: Pain is highly subjective and it is neurologically proven that stimulation of larger diameter fibers - e.g., using appropriate coldness, warmth, rubbing, pressure or vibration - can close the neural "gate" so that the central perception of itch and pain is reduced. This fact is based upon "gate control" theory of Melzack and Wall. The present study was carried out to investigate the effects of vibration stimuli on pain experienced during local anesthetic injections. MATERIALS AND METHODS: Thirty patients aged 6-12 years old of both the genders with Frankel's behavior rating scale as positive and definitely positive requiring bilateral local anesthesia injections for dental treatment were included in the split-mouth cross over design...
July 2015: Journal of the Indian Society of Pedodontics and Preventive Dentistry
https://www.readbyqxmd.com/read/26005075/-occipital-nerve-stimulation-for-refractory-chronic-migraine
#12
REVIEW
Pedro E Bermejo, Cristina V Torres, Rafael G Sola
INTRODUCTION: Occipital nerve stimulation (ONS) is an emerging and promising preventive treatment for refractory chronic migraine. AIM: To evaluate the mechanisms of actions, clinical studies, implantation techniques and inclusion criteria of the ONS as a preventive treatment for migraine. DEVELOPMENT: This work includes a non-systematic review of the literature on the above-mentioned aspects of ONS as a treatment for refractory chronic migraine...
June 1, 2015: Revista de Neurologia
https://www.readbyqxmd.com/read/25963291/are-primary-and-secondary-provoked-vestibulodynia-two-different-entities-a-comparison-of-pain-psychosocial-and-sexual-characteristics
#13
COMPARATIVE STUDY
Leen Aerts, Sophie Bergeron, Serena Corsini-Munt, Marc Steben, Myriam Pâquet
INTRODUCTION: Provoked vestibulodynia (PVD) is suspected to be the most frequent cause of vulvodynia in premenopausal women. Based on the onset of PVD relative to the start of sexual experience, PVD can be divided into primary (PVD1) and secondary PVD (PVD2). Studies comparing these PVD subgroups are inconclusive as to whether differences exist in sexual and psychosocial functioning. AIM: The aim of this study was to compare the pain, sexual and psychosocial functioning of a large clinical and community-based sample of premenopausal women with PVD1 and PVD2...
June 2015: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/25885295/spinal-cord-stimulation-current-applications-for-treatment-of-chronic-pain
#14
REVIEW
Prasad Vannemreddy, Konstantin V Slavin
Spinal cord stimulation (SCS) is thought to relieve chronic intractable pain by stimulating nerve fibers in the spinal cord. The resulting impulses in the fibers may inhibit the conduction of pain signals to the brain, according to the pain gate theory proposed by Melzack and Wall in 1965 and the sensation of pain is thus blocked. Although SCS may reduce pain, it will not eliminate it. After a period of concern about safety and efficacy, SCS is now regaining popularity among pain specialists for the treatment of chronic pain...
January 2011: Anesthesia, Essays and Researches
https://www.readbyqxmd.com/read/25882267/pain-and-fatigue-in-elderly-cancer-patients-turkey-example
#15
Melek Erturk, Yasemin Yildirim, Serap Parlar Kilic, Serap Ozer, Fisun Senuzun Aykar
The aim of this study was to evaluate the pain and fatigue levels of elderly cancer patients and to examine whether pain is an independent variable in fatigue development. A total of 250 elderly cancer patients undergoing treatment in the outpatient chemotherapy units and internal medicine clinic at 2 hospitals were enrolled. A "Patient Information Form," the "McGill Melzack Pain Questionnaire," and the "Brief Fatigue Inventory" were used as data instruments. It was determined that all patients had pain and that the mean present pain intensity score was 2...
May 2015: Holistic Nursing Practice
https://www.readbyqxmd.com/read/25712169/composite-pain-index-reliability-validity-and-sensitivity-of-a-patient-reported-outcome-for-research
#16
Diana J Wilkie, Robert E Molokie, Marie L Suarez, Miriam O Ezenwa, Zaijie J Wang
OBJECTIVE: A single score that represents the multidimensionality of pain would be an innovation for patient-reported outcomes. Our aim was to determine the reliability, validity, and sensitivity of the Composite Pain Index (CPI). DESIGN: Methodological analysis of data from a randomized controlled, pretest/post-test education-based intervention study. SETTING: The study was conducted in outpatient oncology clinics. SUBJECTS: The 176 subjects had pain, were 52 ± 12...
July 2015: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/25709702/evaluation-of-the-effects-of-ice-massage-applied-to-large-intestine-4-hegu-on-postpartum-pain-during-the-active-phase-of-labor
#17
Hafize Ozturk Can, Aynur Saruhan
BACKGROUND: The uterus continues to contract after childbirth. The pain caused by the contractions of the uterus can be as severe as labor pain. The study was aimed to evaluate the effects of ice massage applied to the large intestine 4 (LI4) on postpartum pain during the active phase of labor. MATERIALS AND METHODS: The study was designed as a randomized controlled trial with three groups and carried out in two stages. The study sample comprised of 150 pregnant women, who were referred to a maternity hospital...
January 2015: Iranian Journal of Nursing and Midwifery Research
https://www.readbyqxmd.com/read/25638694/history-and-present-state-of-targeted-intrathecal-drug-delivery
#18
REVIEW
Syed Rizvi, Krishna Kumar
Nearly 50 years ago, the seminal experiments of Melzack and Wall, culminating in the gate control theory, coupled with the discovery of endogenous opioid receptors, helped shape modern understandings of pain and provided interventionalists a potent therapeutic gateway to neuraxial analgesia. This paper emphasizes the historical antecedents, present state, and emerging future of the neuromodulatory technique of targeted intrathecal drug delivery (TIDD) for chronic pain. The strengths of TIDD are its customizability, reversibility, programmability, and low risk profile...
2015: Current Pain and Headache Reports
https://www.readbyqxmd.com/read/25420137/illusory-reduplication-of-one-s-own-body-phenomenology-and-classification-of-autoscopic-phenomena
#19
P Brugger, M Regard, T Landis
Autoscopic phenomena involve the illusory reduplication of one's own body. The literature on the topic is widely scattered and suffers from considerable terminological and conceptual inconsistencies. This article proposes a classification scheme based on phenomenological criteria. Along with examples of illustrative cases, we outline the main features of autoscopic hallucinations, heautoscopy proper, the feeling of a presence, the out-of-body experience, and negative and inner forms of autoscopic phenomena...
February 1, 1997: Cognitive Neuropsychiatry
https://www.readbyqxmd.com/read/25026568/electro-analgesia
#20
F R Berry, W B Conolly, J G Mcleod, E J Inglis
Between May 1975 and March 1976, 19 patients with pain or hypersensitivity, or both, in the distribution of a peripheral nerve were treated with electro-analgesia in the physiotherapy department of Sydney Hospital. The rationale for this treatment is the work of Melzack and Wall (1965). The current selected was that used by Meyer and Field (1972), a unidirectional square wave current with pulse length of 0.1 millisecond at a frequency of 100 Hertz. The machine used was a GRASS S48 stimulator, which is a highly accurate instrument...
June 1977: Australian Journal of Physiotherapy
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