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Trichomonas vaginalis

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https://www.readbyqxmd.com/read/29792148/homopiperazine-derived-female-controlled-vaginal-trichomonacidal-contraceptive-an-addition-to-structure-activity-relationship
#1
B S Rahul, Bindu Saraswati, C Shiju, Gopal Gupta, Nand Lal
BACKGROUND: In our previous work, several piperazine derived bis(dialkylaminethiocarbonyl) disulfides and disulfide esters of dithiocarbamic acid have been synthesized and evaluated for their spermicidal and microbicidal efficacy. These studies have provided some promising compounds for developing a dually active vaginal microbicidal contraceptive which are under pre-clinical stage [1, 16, 17]. OBJECTIVE: The main objective of this study was to design, synthesis and biological evaluation of bis(dialkylaminethiocarbonyl) disulfides (4-15) and 2,2'-disulfanediylbis (3-(substituted- 1-yl) propane-2,1-diyl) disubstituted-1-carbodithioates (19-28) as non-surfactant molecules capable of eliminating Trichomonas vaginalis as as well as irreversibly immobilizing 100% human sperm promptly...
May 23, 2018: Medicinal Chemistry
https://www.readbyqxmd.com/read/29784856/a-cell-surface-aggregation-promoting-factor-from-lactobacillus-gasseri-contributes-towards-inhibition-of-trichomonas-vaginalis-adhesion-to-human-vaginal-ectocervical-cells
#2
Niha Phukan, Anna E S Brooks, Augusto Simoes-Barbosa
Trichomoniasis, a prevalent sexually transmitted infection, is commonly symptomatic in women. The causative agent is Trichomonas vaginalis , an extracellular protozoan parasite. The host-protective mechanisms and molecules of vaginal lactobacilli that could counteract with this pathogen are largely unknown. This study examines the inhibition promoted by Lactobacillus gasseri against the adhesion of T. vaginalis to host cells, a critical virulence aspect of this pathogen. We observed that the vaginal L. gasseri ATCC 9857 is highly inhibitory by various contact-dependent mechanisms and surface proteins are largely responsible for this inhibitory phenotype...
May 21, 2018: Infection and Immunity
https://www.readbyqxmd.com/read/29782292/evaluation-of-symptomatic-patients-with-resistant-discharge
#3
Cemile Sonmez, Selma Usluca, Ismail Hakki Usluca, Irem Kalipci, Figen Sezen, Cemal Resat Atalay, Selcuk Kilic
The aim of this study was to detect the presence of Chlamydia trachomatis, Neisseria (N.) gonorrhoeae, Mycoplasma (M.) hominis, M. genitalium, Ureaplasma (U.) urealyticum, and Trichomonas (T.) vaginalis in patients with resistant discharge. The study also evaluated the concordance of the diagnostic tests. Samples from 156 patients were tested by direct microscopy and culture for T. vaginalis and Mycoplasma IES for M. hominis and U. urealyticum. Multiplex Polymerase Chain Reaction (PCR) was used to determine the presence of six agents...
April 2018: Acta Dermatovenerologica Croatica: ADC
https://www.readbyqxmd.com/read/29780013/use-of-internal-transcribed-spacer-sequence-polymorphisms-as-a-method-for-trichomonas-vaginalis-genotyping
#4
Hatice Ertabaklar, Sema Ertuğ, Serçin Özlem Çalışkan, Erdoğan Malatyalı, Bülent Bozdoğan
OBJECTIVE: Trichomonas vaginalis is the most common non-viral, sexually transmitted pathogen with a worldwide distribution. The aim of the present study was to design a new genotyping tool for T. vaginalis isolates using internal transcribed spacer (ITS) sequences. METHODS: First, a total of 20 cryopreserved T. vaginalis isolates were thawed and genomic DNA was isolated from fresh cultures. A polymerase chain reaction (PCR) was performed to amplify the ITS regions and the amplicons were sequenced...
March 2018: Türkiye Parazitolojii Dergisi
https://www.readbyqxmd.com/read/29768419/a-secreted-heat-shock-protein-90-of-trichomonas-vaginalis
#5
Meetali Singh, Divya Beri, Rishi Kumar Nageshan, Leena Chavaan, Darshak Gadara, Mukta Poojary, Suraj Subramaniam, Utpal Tatu
Trichomonas vaginalis is a causative agent of Trichomoniasis, a leading non-viral sexually transmitted disease worldwide. In the current study, we show Heat shock protein 90 is essential for its growth. Upon genomics analysis of the parasite, it was found to possess seven ORFs which could potentially encode Hsp90 isoforms. We identified a cytosolic Hsp90 homolog, four homologs which can align to truncated cytosolic Hsp90 gene products along with two Grp94 homologs (ER isoform of Hsp90). However, both Grp94 orthologs lacked an ER retention motif...
May 16, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29730454/phase-solubility-studies-and-anti-trichomonas-vaginalis-activity-evaluations-of-metronidazole-and-methylated-%C3%AE-cyclodextrin-complexes-comparison-of-crysmeb-and-rameb
#6
Sophia Malli, Christian Bories, Gilles Ponchel, Philippe M Loiseau, Kawthar Bouchemal
Metronidazole (MTZ) is a 5-nitroimidazole drug used for the treatment of Trichomonas vaginalis parasitic infection. Aqueous formulations containing MTZ are restricted because apparent solubility in water of this drug is low. In this context, two methylated-β-cyclodextrins (CRYSMEB and RAMEB) were used as a tool to increase apparent solubility of MTZ in water. CRYSMEB was limited by its own solubility in water (15% w/w, 12.59 mM), while RAMEB at a concentration of 40% w/w (300.44 mM) allowed a maximal increase of apparent solubility of MTZ (3...
April 27, 2018: Experimental Parasitology
https://www.readbyqxmd.com/read/29706149/management-of-sexually-transmissible-infections-in-the-era-of-multiplexed-molecular-diagnostics-a-primary-care-survey
#7
Tal Brosh-Nissimov, Ron Kedem, Nimrod Ophir, Omri Shental, Nathan Keller, Sharon Amit
Background: Data regarding sexually transmissible infections (STI) often originate from STI clinics, screening programs or laboratory-based studies, thus are biased for specific risk groups or lack clinical details. This real-life observational study presents sample data of most young adult Israeli population by exploiting the centralised diagnostic and documentation platforms resulting from a mandatory military service at the age of 18 years for both genders. Methods: All STI diagnoses of Israeli Defence Forces soldiers during a 6-month period were reviewed...
April 30, 2018: Sexual Health
https://www.readbyqxmd.com/read/29692771/-trichomonas-vaginalis-induces-production-of-proinflammatory-cytokines-in-mouse-macrophages-through-activation-of-mapk-and-nf-%C3%AE%C2%BAb-pathways-partially-mediated-by-tlr2
#8
Ling Li, Xin Li, Pengtao Gong, Xichen Zhang, Zhengtao Yang, Ju Yang, Jianhua Li
Trichomoniasis, caused by Trichomonas vaginalis infection, is the most prevalent sexually transmitted disease in female and male globally. However, the mechanisms by innate immunity against T. vaginalis infection have not been fully elucidated. Toll-like receptor2 (TLR2) has been shown to be involved in pathogen recognition, innate immunity activation, and inflammatory response to the pathogens. Nonetheless, the function of TLR2 against T. vaginalis remains unclear. In the present study, we investigated the role of TLR2 in mouse macrophages against T...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29689080/beyond-syndromic-management-opportunities-for-diagnosis-based-treatment-of-sexually-transmitted-infections-in-low-and-middle-income-countries
#9
Nigel J Garrett, Farzana Osman, Bhavna Maharaj, Nivashnee Naicker, Andrew Gibbs, Emily Norman, Natasha Samsunder, Hope Ngobese, Nireshni Mitchev, Ravesh Singh, Salim S Abdool Karim, Ayesha B M Kharsany, Koleka Mlisana, Anne Rompalo, Adrian Mindel
INTRODUCTION: In light of the limited impact the syndromic management approach has had on the global sexually transmitted infection (STI) epidemic, we assessed a care model comprising point-of-care (POC) STI testing, immediate treatment, and expedited partner therapy (EPT) among a cohort of young women at high HIV risk in South Africa. METHODS AND FINDINGS: HIV negative women presenting for STI care underwent POC testing for Chlamydia trachomatis (CT), Neisseria gonorrhoeae (NG) and Trichomonas vaginalis (TV), and swabs were sent for NG culture and susceptibility testing...
2018: PloS One
https://www.readbyqxmd.com/read/29676341/the-prevalence-and-risk-factors-for-trichomonas-vaginalis-infection-amongst-human-immunodeficiency-virus-infected-pregnant-women-attending-the-antenatal-clinics-of-a-university-teaching-hospital-in-lagos-south-western-nigeria
#10
Olaolopin Ijasan, Kehinde Sharafadeen Okunade, Ayodeji Ayotunde Oluwole
Background: Trichomonas vaginalis infection is the most prevalent non-viral sexually transmitted infection worldwide. Interactions between this infection and human immunodeficiency virus (HIV) may cause adverse pregnancy outcomes such as preterm labour, premature rupture of membranes, chorioamnionitis, low birth weight and post-abortal sepsis. Aims: This study was aimed to determine the prevalence and risk factors of T. vaginalis infection amongst HIV-positive pregnant women attending antenatal care at the Lagos University Teaching Hospital (LUTH), Lagos, Nigeria...
January 2018: Nigerian Postgraduate Medical Journal
https://www.readbyqxmd.com/read/29660492/characterization-of-multiple-enolase-ggenes-from-trichomonas-vaginalis-potential-novel-targets-for-drug-and-vaccine-design
#11
Elibeth Mirasol-Meléndez, Luis G Brieba-de Castro, Corina Díaz-Quezada, Marisol López-Hidalgo, Elisa E Figueroa-Angulo, Leticia Ávila-González, Rossana Arroyo-Verástegui, Claudia G Benítez-Cardoza
Trichomonas vaginalis is the protist parasite that causes the most common, non-viral sexually transmitted infection called trichomonosis. Enolase is a moonlighting protein that apart from its canonical function as a glycolytic enzyme, serves as a plasminogen receptor on the cell surface of T. vaginalis and, in consequence, it has been stablished as a virulence factor in this parasite. In the Trichomonas vaginalis sequence database there are nine genes annotated as enolase. In this work, we analyzed these genes as well as their products...
April 13, 2018: Parasitology International
https://www.readbyqxmd.com/read/29660412/mycoplasma-hominis-shows-strain-dependent-increase-of-resistance-to-selected-antibiotics-after-symbiosis-with-trichomonas-vaginalis
#12
Ursula Fürnkranz, Julia Walochnik, Birgit Henrich
OBJECTIVES: Mycoplasma hominis, a genetically heterogeneous, cell-wall less bacterium, is able to live in symbiosis with the protozoan parasite Trichomonas vaginalis. While impacts of this symbiosis on T. vaginalis have been investigated to a certain extent, less light has been shed on the influence on M. hominis. METHODS: In an in vitro minimal inhibitory concentration (MIC) study the antibiotic susceptibility of three clinical M. hominis isolates, V475, AKH136 and MhSS10, to clindamycin, moxifloxacin, ciprofloxacin and gentamicin was investigated in dependence on symbiosis with T...
April 13, 2018: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/29653033/organometallic-conjugates-of-the-drug-sulfadoxine-for-combatting-antimicrobial-resistance
#13
Peter J Sadler, Prinessa Chellan, Vicky Avery, Sandra Duffy, James Triccas, Gayathri Nagalingam, Christina Tam, Luisa Cheng, Jenny Liu, Kirkwood Land, Guy Clarkson, Isolda Romero
Fourteen novel arene RuII, and cyclopentadienyl (Cpx) RhIII and IrIII complexes containing an N,N'-chelated pyridylimino- or quinolylimino ligand functionalized with the antimalarial drug sulfadoxine have been synthesized and characterized, including three by x-ray crystallography. Rhodium and iridium complexes exhibited potent antiplasmodial activity with IC50 values of 0.10 - 2.0 µM in either all, or one of the three Plasmodium falciparum assays (3D7 chloroquine sensitive, Dd2 chloroquine resistant and NF54 sexual late stage gametocytes), but were only moderately active towards Trichomonas vaginalis...
April 13, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29643195/diagnostic-performance-of-a-molecular-test-versus-clinician-assessment-of-vaginitis
#14
Jane R Schwebke, Charlotte A Gaydos, Paul Nyirjesy, Sonia Paradis, Salma Kodsi, Charles K Cooper
Background: Vaginitis is a common complaint, diagnosed either empirically or using Amsel's criteria and wet mount microscopy. Objective: To determine characteristics of an investigational test (a molecular-based test for vaginitis), as compared to reference, for detection of bacterial vaginosis, Candida spp., and Trichomonas vaginalis Study Design: Vaginal specimens from a cross-sectional study were obtained from 1,740 women (≥18 years old), with vaginitis symptoms, during routine clinic visits (across 10 sites in the USA)...
April 11, 2018: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29624912/antichagasic-leishmanicidal-and-trichomonacidal-activity-of-2-benzyl-5-nitroindazole-derived-amines
#15
Vicente J Aran, Cristina Fonseca-Berzal, Alexandra Ibáñez-Escribano, Nerea Vela, José Cumella, Juan José Nogal-Ruiz, José Antonio Escario, Patrícia Bernardino da Silva, Marcos Meuser Batista, Maria de Nazaré C Soeiro, Sergio Sifontes-Rodriguez, Alfredo Meneses-Marcel, Alicia Gómez-Barrio
Three different series of new 5-nitroindazole derivatives, 1-(ω-aminoalkyl)-2-benzylindazolin-3-ones (series A; 10 compounds), 3-(ω-aminoalkoxy)-2-benzylindazoles (series B; 4 compounds) and 3-alkylamino-2-benzylindazoles (series C; 5 compounds), have been synthesized and evaluated against the protozoan parasites Trypanosoma cruzi, Leishmania amazonensis and Trichomonas vaginalis, etiological agents of Chagas disease, cutaneous leishmaniasis and trichomoniasis, respectively. Many indazoles of series A, B and C were efficient against T...
April 6, 2018: ChemMedChem
https://www.readbyqxmd.com/read/29624560/sexual-behaviors-of-hiv-infected-pregnant-women-and-factors-associated-with-sexual-transmitted-infection-in-south-africa
#16
Dvora Joseph Davey, Remco P H Peters, Noah Kojima, Maanda Mudau, Lindsey De Vos, Dawie Olivier, James A McIntyre, Jeffrey D Klausner, Andrew Medina-Marino
BACKGROUND: Sexual behaviors in HIV-infected pregnant women in South Africa are not well understood. METHODS: HIV-infected pregnant women were recruited into a prospective cohort at first antenatal care visit. Sociodemographic information and self-collected vulvovaginal swab samples were collected from participants. Vulvovaginal swab samples were tested for Chlamydia trachomatis (CT), Neisseria gonorrhoea (NG) and Trichomonas vaginalis (TV) using GeneXpert®. We investigated sexual behaviors, alcohol use and factors associated with condomless sex during pregnancy and prevalent sexually transmitted infection (STI) among our cohort...
April 5, 2018: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/29619908/prevalence-of-sexually-transmitted-diseases-in-asymptomatic-renal-transplant-recipients
#17
Mehmet Sarier, Nevgun Sepin Ozen, Hicran Guler, Ibrahim Duman, Yücel Yüksel, Sabri Tekin, Asuman Havva Yavuz, Levent Yucetin, Mine Erdogan Yilmaz
OBJECTIVES: Sexually transmitted diseases, which may be asymptomatic, have the potential to cause serious health problems in renal transplant recipients. The aim of this study was to determine the prevalence of sexually transmitted diseases in sexually active asymptomatic renal transplant patients by using real-time multiplex polymerase chain reaction assays. MATERIALS AND METHODS: This prospective controlled study was conducted between November 2016 and January 2017 in our hospital...
April 4, 2018: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/29615721/structural-basis-of-interaction-between-dimeric-cyclophilin-1-and-myb1-transcription-factor-in-trichomonas-vaginalis
#18
Tesmine Martin, Yuan-Chao Lou, Chun-Chi Chou, Shu-Yi Wei, Sushant Sadotra, Chao-Cheng Cho, Meng-Hsuan Lin, Jung-Hsiang Tai, Chun-Hua Hsu, Chinpan Chen
Cyclophilin 1 (TvCyP1), a cyclophilin type peptidyl-prolyl isomerase present in the human parasite Trichomonas vaginalis, interacts with Myb1 and assists in its nuclear translocation. Myb1 regulates the expression of ap65-1 gene that encodes for a disease causing cytoadherence enzyme. Here, we determined the crystal structures of TvCyP1 and its complex with the minimum TvCyP1-binding sequence of Myb1 (Myb1104-111 ), where TvCyP1 formed a homodimer, unlike other single domain cyclophilins. In the complex structure, one Myb1104-111 peptide was bound to each TvCyP1 protomer, with G106-P107 and Y105 fitting well into the active site and auxiliary S2 pocket, respectively...
April 3, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29608771/aberrant-and-accidental-trichomonad-flagellate-infections-rare-or-underdiagnosed
#19
Chaoqun Yao, Jennifer K Ketzis
The clinical significance and frequency of human infections with trichomonad flagellates in aberrant locations (locations other than the predilection sites) and accidental infections (infections with non-human trichomonads) are unclear. The total number of case reports in the literature is low, with the identification of the infection largely the outcome of investigations for the cause of clinical signs. At least seven species have been identified in either aberrant or accidental infections, with these infections occurring worldwide...
March 28, 2018: Transactions of the Royal Society of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29589477/drug-repositioning-for-novel-antitrichomonas-from-known-antiprotozoan-drugs-using-hierarchical-screening
#20
Alfredo Meneses-Marcel, Yovani Marrero-Ponce, Alexandra Ibáñez-Escribano, Alicia Gómez-Barrio, José A Escario, Stephen J Barigye, Enrique Terán, Cesar R García-Jacas, Yanetsy Machado-Tugores, Juan J Nogal-Ruiz, Vicente J Arán-Redó
AIM: Metronidazole is the most widely used drug in trichomoniasis therapy. However, the emergence of metronidazole-resistant Trichomonas vaginalis isolates calls for the search for new drugs to counter the pathogenicity of these parasites. RESULTS: Classification models for predicting the antitrichomonas activity of molecules were built. These models were employed to screen antiprotozoal drugs, from which 20 were classified as active. The in vitro experiments showed moderate to high activity for 19 of the molecules at 10 μg/ml, while 3 compounds yielded higher activity than the reference at 1 μg/ml...
March 28, 2018: Future Medicinal Chemistry
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