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Trichomonas vaginalis

Harald Preisner, Eli Levy Karin, Gereon Poschmann, Kai Stühler, Tal Pupko, Sven B Gould
Certain protist lineages bear cytoskeletal structures that are germane to them and define their individual group. Trichomonadida are excavate parasites united by a unique cytoskeletal framework, which includes tubulin-based structures such as the pelta and axostyle, but also other filaments such as the striated costa whose protein composition remains unknown. We determined the proteome of the detergent-resistant cytoskeleton of Tetratrichomonas gallinarum. 203 proteins with homology to Trichomonas vaginalis were identified, which contain significantly more long coiled-coil regions than control protein sets...
September 16, 2016: Protist
C van der Veer, M Himschoot, S M Bruisten
OBJECTIVES: In this cross-sectional epidemiological study we aimed to identify molecular profiles for Trichomonas vaginalis and to determine how these molecular profiles were related to patient demographic and clinical characteristics. SETTING: Molecular typing methods previously identified two genetically distinct subpopulations for T. vaginalis; however, few molecular epidemiological studies have been performed. We now increased the sensitivity of a previously described multilocus sequence typing (MLST) tool for T...
October 13, 2016: BMJ Open
(no author information available yet)
Use of metronidazole for bacterial vaginosis and Trichomonas vaginalis should be avoided during the second trimester of pregnancy.
April 4, 2007: Nursing Standard
Charifa Zemouri, Teodora Elvira Wi, James Kiarie, Armando Seuc, Vittal Mogasale, Ahmed Latif, Nathalie Broutet
BACKGROUND: This review aimed to synthesize and analyze the diagnostic accuracy and the likelihood of providing correct treatment of the syndromic approach Vaginal Discharge Flowchart in managing cervical infections caused by Neisseria gonorrhoeae (NG) and Chlamydia trachomatis (CT), and vaginal infections caused by Trichomonas vaginalis (TV) and Bacterial vaginosis (BV) and Candida albicans. This review will inform updating the WHO 2003 guidelines on Vaginal Discharge syndromic case management...
2016: PloS One
Patrícia de Brum Vieira, Tiana Tasca, W Evan Secor
Trichomoniasis is a sexually transmitted disease (STD) caused by infection with the protozoan parasite Trichomonas vaginalis. It is considered the most prevalent non-viral sexually transmitted disease worldwide. Recently, the infection has been associated with adverse outcomes of pregnancy and increased risks of HIV acquisition and transmission, besides the association with cervical and prostate cancers. The consequences of trichomoniasis are likely much greater than previously recognized, both at the individual and the community level...
September 30, 2016: Current Topics in Medicinal Chemistry
Nigel Field, Soazig Clifton, Sarah Alexander, Catherine A Ison, Rumena Khanom, Pamela Saunders, Gwenda Hughes, Laura Heath, Simon Beddows, Catherine H Mercer, Clare Tanton, Anne M Johnson, Pam Sonnenberg
INTRODUCTION: Variable use of new molecular assays, asymptomatic infections and a lack of population data mean that the population burden of Trichomonas vaginalis is uncertain. We investigated the age-specific prevalence of T. vaginalis within the sexually active British general population to inform testing strategies. METHODS: Britain's third National Survey of Sexual Attitudes and Lifestyle (Natsal-3) is a probability sample survey of 15 162 individuals aged 16-74 years, undertaken during 2010-2012...
September 29, 2016: Sexually Transmitted Infections
Dariana Pimentel Gomes Hübner, Patrícia de Brum Vieira, Amanda Piccoli Frasson, Camila Braz Menezes, Franciane Rios Senger, Gloria Narjara Santos da Silva, Simone Cristina Baggio Gnoatto, Tiana Tasca
Caused by Trichomonas vaginalis, trichomoniasis is the most common non-viral STD worldwide. Currently, metronidazole and tinidazole are the only drugs approved for treatment of the condition. However, problems such as metronidazole-resistant T. vaginalis isolates and allergic reactions have been reported. Based on data previously published by our group, structural changes in betulinic acid (1) were performed, generating three new compounds that were tested for in vitro anti-T.vaginalis activity in this study...
September 26, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Cíntia Lima Ambrozio, Andréia Saggin Nagel, Sabrina Jeske, Guilherme Cassão Marques Bragança, Sibele Borsuk, Marcos Marreiro Villela
Trichomonas vaginalis infections have been associated with other diseases so that epidemiological studies of the parasite are important and help to prevent the spread of the disease. This study aimed to determine the prevalence of T. vaginalis in female patients of 19 counties in southwestern Rio Grande do Sul, Brazil. For diagnosis, was used direct examination, followed by applying a socio-epidemiological questionnaire. We analyzed 300 women and 9% were infected by Trichomonas vaginalis. The highest frequency occurred in women between 18 and 39 years old, single/divorced/widowed, whose family income was at one minimum wage or less, and they had not completed the primary school...
2016: Revista do Instituto de Medicina Tropical de São Paulo
Mariana da Silva Dias, Camila Braz Menezes, Tiana Tasca
This study compared preservative solutions at different temperatures aiming to improve the wet mount for trichomoniasis diagnosis. The glucose-saline pH6.0 solution preserved the trophozoites up to 6h. The urine samples preservation is crucial for diagnosis and we suggest this solution as part of the clinical laboratorial routine.
November 2016: Journal of Microbiological Methods
Jamshaid Iqbal, Jumanah Al-Rashed, Elijah O Kehinde
BACKGROUND: Despite a worldwide common and progressive nature of benign prostate hyperplasia (BPH) in older men, no association has been observed between a causative pathogen and other etiology so far. METHODS: In this study, we investigated a causative association of Trichomonas vaginalis, a flagellate protozoan parasite, in 171 BPH cases presenting without symptoms of prostatitis at a surgical outpatient clinic in Kuwait. We detected T. vaginalis DNA by polymerase chain reaction (PCR) and T...
2016: BMC Infectious Diseases
Subhojit Dey, Parika Pahwa, Arti Mishra, Jyotsna Govil, Preet K Dhillon
OBJECTIVES: Burden of cervical cancer (CC) is highest for women in low- and middle-income countries (LMICs). Human papillomavirus (HPV) is implicated as the necessary cause of CC although a number of other factors aid the long process of CC development. One among them is the presence of reproductive tract infections (RTIs). This study investigated the associations between RTIs and CC from India. METHODS: This study utilized secondary data from the Cancer Detection Centre of the ICS, Delhi...
October 2016: Journal of Obstetrics and Gynaecology of India
Dhanaraju Mandalapu, Bhavana Kushwaha, Sonal Gupta, Nidhi Singh, Mahendra Shukla, Jitendra Kumar, Dilip K Tanpula, Satya N Sankhwar, Jagdamba P Maikhuri, Mohammad I Siddiqi, Jawahar Lal, Gopal Gupta, Vishnu L Sharma
Trichomoniasis is the most prevalent, non-viral sexually transmitted diseases (STD) caused by amitochondriate protozoan Trichomonas vaginalis. Increased resistance of T. vaginalis to the marketed drug Metronidazole necessitates the development of newer chemical entities. A library of sixty 2-methyl-4/5-nitroimidazole derivatives was synthesized via nucleophilic ring opening reaction of epoxide and the efficacies against drug-susceptible and -resistant Trichomonas vaginalis were evaluated. All the molecules except two were found to be active against both susceptible and resistant strains with MICs ranging 8...
September 4, 2016: European Journal of Medicinal Chemistry
Erika E Doxtader, Tarik M Elsheikh
BACKGROUND: Trichomonas vaginalis is a rare finding in urine cytology specimens, especially those from men; only 2 case reports have been described in the literature. The authors of the current report sought to determine the incidence and clinical significance of this finding in urine cytology in males. METHODS: The authors' cytopathology archives were queried for urine cytology specimens that contained Trichomonas over a 30-year period. Clinical information from men with Trichomonas-positive urines was reviewed retrospectively...
September 16, 2016: Cancer Cytopathology
Alissa Davis, Anindita Dasgupta, Dawn Goddard-Eckrich, Nabila El-Bassel
BACKGROUND: The United States has a large community supervision population, a growing number of whom are women. Trichomonas vaginalis infection is strongly associated with an increased risk of human immunodeficiency virus (HIV) acquisition and transmission, particularly among women, but there is a paucity of research on HIV and T. vaginalis co-infection among women under community supervision. METHODS: This article examines the prevalence of T. vaginalis infection and T...
October 2016: Sexually Transmitted Diseases
Erik Munson, David Wenten, Sheila Jhansale, Mary Kay Schuknecht, Nicki Pantuso, Joshua Gerritts, Aaron Steward, Kimber L Munson, Maureen Napierala, Deb Hamer
Of 1493 male sexually-transmitted infection (STI) clinic encounters in a high-prevalence STI community, 8.7% revealed detection of Chlamydia trachomatis and 6.6% revealed detection of Neisseria gonorrhoeae Additional Trichomonas vaginalis and Mycoplasma genitalium screening resulted in 17.4% and 23.9% of encounters positive for STI, respectively. STI agents were detected in 13.7% of urine specimens; addition of pharyngeal and rectal collections resulted in detection of STI agents in 19.0% and 23.9% of encounters, respectively...
September 14, 2016: Journal of Clinical Microbiology
Bertha Isabel Carvajal-Gamez, Laura Vázquez Carrillo, Julio César Torres-Romero, Minerva Camacho-Nuez, María Dolores Ponce-Regalado, César López Camarillo, María Elizbeth Alvarez-Sánchez
Trichomonas vaginalis eIF-5A-like protein (TveIF-5A) belongs to the highly conserved eIF-5A family of proteins that contains a unique polyamine-derived amino acid, hypusine. Recently, we determined that the polyamine putrescine is required for tveif-5a mRNA stability, and it is necessary for stability and maturation of the TveIF-5A protein. Eukaryotic eIF-5A is known to be involved in mRNA turnover and is capable of sequence-specific RNA binding to eIF-5A response elements (EREs). These ERE sequences are present in diverse mammalian mRNAs, including human cyclooxygenase-2 (cox-2)...
December 2016: Parasitology International
Anthony J Szempruch, Lauren Dennison, Rudo Kieft, John M Harrington, Stephen L Hajduk
Parasitic unicellular eukaryotes use extracellular vesicles (EVs) as vehicles for intercellular communication and host manipulation. By using various mechanisms to generate EVs and by transferring a wide range of molecules through EVs, pathogenic protozoans are able to establish infective niches, modulate the immune system of the host and cause disease. In addition to effects on the host, EVs are able to transfer virulence factors, drug-resistance genes and differentiation factors between parasites. In this Progress article, we explore recent insights into the biology of EVs from human infectious protozoan parasites, including Trichomonas vaginalis, Plasmodium spp...
November 2016: Nature Reviews. Microbiology
Ziwen Zhu, Kristoffer T Davidson, Andrew Brittingham, Mark R Wakefield, Qian Bai, Huaping Xiao, Yujiang Fang
Prostate cancer (PCA) is the most common malignancy in men in USA, and the role of Trichomonas vaginalis (T. vag) in the development of PCA is still controversial. Clonogenic assay, PCNA staining, TUNEL staining and caspase-3 activity assay were used to investigate the in vitro role of T. vag in human prostate cancer. We further investigated the possible molecular mechanisms using RT-PCR and immunohistochemical staining. Culture supernatant of T. vag inhibits growth of PC-3 prostate cancer cells, and this correlated with upregulation of p21...
October 2016: Medical Oncology
Heba AbdelKader Aminou, Yosra Hussein Alam-Eldin, Hanan Ahmed Hashem
Trichomonas vaginalis is a parasitic protozoan that is the aetiological agent of trichomoniasis, the most common non-viral sexually transmitted disease worldwide. Currently, the compound of choice for the treatment of T. vaginalis infections is metronidazole, however, it has many side effects and an increase in metronidazole-resistant trichomoniasis has been observed. Medicinal plants could be a source of new antiprotozoal drugs with high activity, low toxicity and lower price. The present work was carried out to investigate the therapeutic potential of Nigella sativa alcoholic extract and oil, as well as Phaseolus vulgaris (kidney bean) lectin and their in vitro activity on the ultrastructure of T...
September 2016: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
Néstor Casillas-Vega, Rayo Morfín-Otero, Santos García, Jorge Llaca-Díaz, Eduardo Rodríguez-Noriega, Adrián Camacho-Ortiz, Ma de la Merced Ayala-Castellanos, Soraya Mendoza-Olazarán, Samantha Flores-Treviño, Santiago Petersen-Morfín, Héctor J Maldonado-Garza, Francisco J Bosques-Padilla, Elvira Garza-González
OBJECTIVE: To determine the frequency of nine sexually transmitted pathogens, coinfections and risk factors in patients attending obstetrics and gynecology clinics in Jalisco, Mexico. MATERIALS AND METHODS: Samples from 662 patients attending obstetrics and gynecology clinics were analyzed. Treponema pallidum, HIV, and HCV were detected by serology. HPV was detected by Polimerase Chain Reaction (PCR), and its genotype was determined by Restriction Fragment Length Polymorphism (RFLP)...
August 2016: Salud Pública de México
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