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Trichomonas vaginalis

Eshan U Patel, Charlotte A Gaydos, Zoe R Packman, Thomas C Quinn, Aaron A R Tobian
Background: The epidemiology of Trichomonas vaginalis (TV) infection in the United States is poorly defined. Methods: Males and females aged 18-59 years who participated in the 2013-2014 National Health and Nutrition Examination Survey and provided a urine specimen were tested for TV infection (n = 4057). Participants were also examined for Chlamydia trachomatis (CT) infection, genital human papillomavirus (HPV) infection, and herpes simplex virus type 2 serostatus...
March 15, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Christina A Muzny
No abstract text is available yet for this article.
March 15, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Ryoichi Hamasuna, Masahiro Matsumoto, Phuong Thi LE, Naohiro Fujimoto, Tetsuro Matsumoto
Mycoplasma genitalium is one of the pathogenic microorganisms in male urethritis as a sexually transmitted infection (STI). M.genitalium is detected in the urine specimens of 15-25% male patients with urethritis. The emergence of macrolide- or fluoroquinolone-resistant M.genitalium has become a serious problem in the treatment of male urethritis worldwide, but there is no commercial-based detecting kits accepted by the national insurance in Japan. In this study, we tested the validity of a molecular kit for detecting seven microorganisms related to STI (Anyplex™ II STI-7 Detection which detects Neisseria gonorrhoeae, Chlamydia trachomatis, M...
2018: Journal of UOEH
I Nikas, A Hapfelmeier, M Mollenhauer, D Angermeier, M Bettstetter, R Götz, M Schmidmayr, V Seifert-Klauss, A Muckenhuber, U Schenck, Gregor Weirich
Pathogenic microbes may colonize the female genital tract via sexual transmission and cause health issues like inflammation or malignancy, summarized as sexually transmitted disease (STD). A major representative of such pathogens is Trichomonas vaginalis (T.v.), whose role in the etiology of cervical cancer remains elusive. Traditional morphologic screening of cervical smears is able to detect T.v., although its identification may be complicated by look-alikes such as degenerated granulocytes and basal cells...
March 17, 2018: Parasitology Research
Azucena Muñoz-Ramírez, Aracely López-Monteon, Angel Ramos-Ligonio, Enrique Méndez-Bolaina, Mario R B Guapillo-Vargas
Female sex workers (FSWs) have been considered a key population for sexually transmitted infections (STIs); therefore, they are periodically screened as a requirement to obtain a work card. However, there is insufficient epidemiological data on STIs among FSWs in Mexico. The detection of Trichomonas vaginalis is limited to microscopic studies and the molecular screening of Human papillomavirus (HPV) is only done to women 35 years of age and older. The objective of this study was to determine the prevalence of T...
March 13, 2018: Revista Argentina de Microbiología
Piera Valenti, Luigi Rosa, Daniela Capobianco, Maria Stefania Lepanto, Elisa Schiavi, Antimo Cutone, Rosalba Paesano, Paola Mastromarino
The innate defense system of the female mucosal genital tract involves a close and complex interaction among the healthy vaginal microbiota, different cells, and various proteins that protect the host from pathogens. Vaginal lactobacilli and lactoferrin represent two essential actors in the vaginal environment. Lactobacilli represent the dominant bacterial species able to prevent facultative and obligate anaerobes outnumber in vaginal microbiota maintaining healthy microbial homeostasis. Several mechanisms underlie the protection exerted by lactobacilli: competition for nutrients and tissue adherence, reduction of the vaginal pH, modulation of immunity, and production of bioactive compounds...
2018: Frontiers in Immunology
C L Shannon, C C Bristow, N A Hoff, A Wynn, M Nguyen, A Medina-Marino, J Cabeza, A W Rimoin, J D Klausner
BACKGROUND: Chlamydia trachomatis (CT), Neisseria gonorrhoeae (NG), and Trichomonas vaginalis (TV) infections during pregnancy are linked with adverse birth outcomes. However, few countries have prenatal CT, NG, or TV screening programs. In this study, we aimed to evaluate the acceptability and feasibility of CT, NG, and TV screening and treatment among pregnant women across six low-to-middle income countries. METHODS: A total 1,817 pregnant women were screened for CT, NG, and TV in Botswana, the Democratic Republic of Congo (DRC), Haiti, South Africa, and Vietnam...
March 9, 2018: Sexually Transmitted Diseases
Martina Bradic, Jane M Carlton
No abstract text is available yet for this article.
March 2018: PLoS Pathogens
María Elizbeth Alvarez-Sánchez, Laura Itzel Quintas-Granados, Laura Isabel Vázquez-Carrillo, Jonathan Puente-Rivera, Alma Villalobos-Osnaya, María Dolores Ponce-Regalado, Minerva Camacho-Nuez
Infection with Trichomonas vaginalis produces a malodorous seropurulent vaginal discharge due to several chemicals, including polyamines. The presence of 1,4-diamino-2-butanone (DAB) reduces the amount of intracellular putrescine by 90%, preventing the cotransport of exogenous spermine. DAB-treated parasites present morphological changes, which are restored by adding exogenous putrescine into the culture medium. However, the effect of polyamines over the trichomonad proteomic profile is unknown. In this study, we used a proteomic approach to analyze the polyamine-depletion and restoration effect by exogenous putrescine on T...
March 7, 2018: Parasitology Research
Mamadou Saidou Barry, Awa Ba Diallo, Mohamed Diadhiou, Ibrahima Mall, Omar Gassama, Mame Diarra Ndiaye Guèye, Serge Covi-Alavo, Epainete Gawa, Amy Ndao Fall, Aissatou Gaye Diallo, Jean Charles Moreau
OBJECTIVE: To assess the effectiveness of the WHO syndromic algorithm in the management of vaginal discharge among women of reproductive age in Dakar. METHODS: Cross-sectional study of consecutive female patients (aged 18-49 years) presenting with vaginal symptoms at six selected study sites in Dakar; of these, 276 patients were included in the analysis. Vaginal and cervical swab samples were collected and analysed to establish an aetiological diagnosis of any infection...
March 5, 2018: Tropical Medicine & International Health: TM & IH
M O Chacon, T H S Fonseca, S B V Oliveira, M A Alacoque, L L Franco, C A Tagliati, G D Cassali, G P Campos-Mota, R J Alves, L S A Capettini, Maria Aparecida Gomes
Trichomoniasis is the most common non-viral, sexually transmitted infection affecting humans worldwide. The main treatment for trichomoniasis is metronidazole (MTZ). However, adverse effects and reports of resistance have stimulated the development of therapeutic alternatives. The ease of manipulation of the side chains of MTZ coupled with its safety makes this molecule attractive for the development of new drugs. In this context, we evaluated the activity of the chlorinated MTZ derivative, MTZ-Cl, on sensitive and resistant strains of Trichomonas vaginalis...
March 3, 2018: Parasitology Research
Zhenchao Zhang, Lixia Kang, Weijuan Wang, Xin Zhao, Yuhua Li, Qing Xie, Shuai Wang, Tong He, Han Li, Tingwei Xiao, Yunchao Chen, Suqiong Zuo, Lingmin Kong, Pengju Li, Xiangrui Li
BACKGROUND: Trichomonas vaginalis (TV) is a protozoan parasite that causes trichomoniasis, a sexually transmitted disease, worldwide. In this study, we investigated the prevalence and genetic characterization of T. vaginalis and contrasted the most prevalent strains of T. vaginalis isolated from Xinxiang City, Henan Province, China. RESULTS: In Xinxiang from September 2015 to September 2017, a total of 267 (1.64%, 95% confidence interval, CI: 1.45-1.85) clinical T...
March 2, 2018: Parasites & Vectors
Carolina Sanitá Tafner Ferreira, Márcia Guimarães da Silva, Letícia Gomes de Pontes, Lucilene Delazari Dos Santos, Camila Marconi
OBJECTIVES: The aim of the study was to compare, using a proteomic approach, cervicovaginal fluid (CVF) proteins of women with bacterial vaginosis (BV) with those presenting normal microbiota. MATERIALS AND METHODS: A total of 309 reproductive-aged women were cross-sectionally enrolled. Participants were tested for vaginal candidosis, Trichomonas vaginalis, Chlamydia trachomatis, and Neisseria gonorrhoeae and excluded if positive. Vaginal microbiota was classified microscopically according to Nugent criteria in normal, intermediate, and BV...
February 23, 2018: Journal of Lower Genital Tract Disease
Alissa Davis, Dawn Goddard-Eckrich, Anindita Dasgupta, Nabila El-Bassel
The number of women under community supervision in the United States has increased, and this population has a high risk for sexually transmitted infections (STIs). We examined STI prevalence and multiple risk factors among drug-involved women under community supervision in New York City. Data were from a randomized controlled trial testing the efficacy of a behavioral HIV/STI intervention (Women on the Road to Health [WORTH]) among drug-involved women in the community corrections system in New York City from 2009 to 2012...
January 1, 2018: International Journal of STD & AIDS
Collin M Price, Remco P H Peters, Janré Steyn, Maanda Mudau, Dawie Olivier, Lindsey De Vos, Erika Morikawa, Marleen M Kock, Andrew Medina-Marino, Jeffrey D Klausner
BACKGROUND: Trichomonas vaginalis is a STI associated with increased transmission of HIV and significant adverse birth outcomes; culture and PCR are commonly used in diagnosis. METHODS: Consenting HIV-infected pregnant women were recruited from clinics in South Africa and screened for T. vaginalis using PCR. PCR-positive women provided an additional sample for culture. We compared T. vaginalis detection between PCR and culture, and investigated how PCR cycle threshold (Ct) values differ among culture results...
November 7, 2017: Sexually Transmitted Diseases
J Schwebke, A Merriweather, S Massingale, M Scisney, C Hill, D Getman
Men and women attending family planning and sexually transmitted disease clinics for STI screening in 2012-2013 were tested for Trichomonas vaginalis (TV) using a sensitive nucleic acid amplification test. TV prevalence in urogenital samples from 77,740 women was 11.3%, 6.1% in 12,604 men, and increased with age in both genders.This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited...
November 14, 2017: Sexually Transmitted Diseases
Z Mike Chirenje, Nicholas Dhibi, H Hunter Handsfield, Elizabeth Gonese, Beth Tippett Barr, Lovemore Gwanzura, Ahmed S Latif, Dumisili Venessa Maseko, Ranmini S Kularatne, Mufuta Tshimanga, Peter H Kilmarx, Anna Machiha, Owen Mugurungi, Cornelis A Rietmeijer
INTRODUCTION: Symptomatic vaginal discharge is a common gynecological condition managed syndromically in most developing countries. In Zimbabwe, women presenting with symptomatic vaginal discharge are treated with empirical regimens that commonly cover both sexually transmitted infections (STI) and reproductive tract infections, typically including a combination of an intramuscular injection of kanamycin, and oral doxycycline and metronidazole regimens. This study was conducted to determine the current etiology of symptomatic vaginal discharge and assess adequacy of current syndromic management guidelines...
November 29, 2017: Sexually Transmitted Diseases
Alexandre Lockhart, Matt Psioda, Jie Ting, Sara Campbell, Nelly Mugo, Jessie Kwatampora, Michael Chitwa, Joshua Kimani, Anne Gakure, Jennifer S Smith
BACKGROUND: To examine the agreement between sexually transmitted infection (STI) screening using self-collected specimens and physician-collected specimens, and to investigate the acceptability of self-collection for screening in an 18-month study of female sex-workers (FSW) in a high-risk, low-resource setting. METHODS: A total of 350 FSW in Nairobi, Kenya participated in a prospective study from 2009-2011. Women self-collected a cervico-vaginal specimen. Next, a physician conducted a pelvic examination to obtain a cervical specimen...
January 2, 2018: Sexually Transmitted Diseases
Yesica R Nievas, Ajay A Vashisht, Maria M Corvi, Sebastian Metz, Patricia J Johnson, James A Wohlschlegel, Natalia de Miguel
The flagellated protozoan parasite Trichomonas vaginalis is the etiologic agent of trichomoniasis, the most common non-viral sexually transmitted infection worldwide. As an obligate extracellular pathogen, adherence to epithelial cells is critical for parasite survival within the human host and a better understanding of this process is a prerequisite for the development of therapies to combat infection. In this sense, recent work has shown S-acylation as a key modification that regulates pathogenesis in different protozoan parasites...
February 14, 2018: Molecular & Cellular Proteomics: MCP
Thaisa Helena Silva Fonseca, Marina Alacoque, Fabrício Marcus Silva Oliveira, Betânia Maria Soares, Henrique Vitor Leite, Marcelo Vidigal Caliari, Maria Aparecida Gomes, Haendel Busatti
The emergence of nitroimidazole resistant isolates has been an aggravating factor in the treatment of trichomoniasis, the most common non-viral sexually transmitted disease in the world. This particularity highlights the importance of new technologies that are safe, effective, and have minor side effects or resistance. Hence, we evaluated the effectiveness of photodynamic therapy on the inactivation of Trichomonas vaginalis in vitro. We used methylene blue as a photosensitizing substance, and a light-emitting diode (LED) for irradiation of metronidazole sensitive and resistant strains...
February 11, 2018: Photodiagnosis and Photodynamic Therapy
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