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https://www.readbyqxmd.com/read/29779113/preparation-and-properties-of-nanoparticles-trna-bivalent-metal-cation-me-2-complexes-and-prospects-of-their-practical-use
#1
V N Danilevich, V V Sorokin, Ya P Moiseev, S V Sizova
The patterns of formation of RNA nanoparticles (NPs) during thermal cycling of bacterial total tRNA in the presence of cations Ca2+ , Mn2+ , Ni2+ , Zn2+ , Co2+ , and Cu2+ were studied. The optimal conditions for the production of NPs were found, and it was revealed that their size depends on the ratio of the concentrations of Me2+ and tRNA. The concentration of reagents for obtaining NPs of small size (from 5 to 100 nm) was selected. It was shown that tRNA-based nanoparticles can comprise short (20-50 nt) ribooligonucleotides, including aptamers and siRNAs...
March 2018: Doklady. Biochemistry and Biophysics
https://www.readbyqxmd.com/read/29779069/highly-sensitive-and-selective-detection-of-amoxicillin-using-carbon-quantum-dots-derived-from-beet
#2
Kunjie Wang, Qingjuan Ji, Jialin Xu, Hongxia Li, Deyi Zhang, Xiaoyu Liu, Yujuan Wu, Haiyan Fan
In the present work, we synthesized the carbon quantum dots (CQDs) by one step hydrothermal method using the dried beet powder as the carbon source without additional chemical reagents and functionalization. The as-prepared CQDs are quasi-spherical carbon nanoparticles with diameters of 4-8 nm as well as surface functional groups such as carboxyl and hydroxyl groups, and exhibit good water-solubility, biocompatibility, and strong fluorescence. It is confirmed that amoxicillin (AMO) could enhance the fluorescent intensity of CQDs, the I/I 0 showed a linear correlation between the intensity of fluorescence and the concentration of AMO in a broad range...
May 19, 2018: Journal of Fluorescence
https://www.readbyqxmd.com/read/29779062/synthesis-and-characterization-of-silibinin-phenanthroline-neocuproine-copper-ii-complexes-for-augmenting-bone-tissue-regeneration-an-in-vitro-analysis
#3
Subramaniyam Rajalakshmi, Selvaraj Vimalraj, Sekaran Saravanan, Desingh Raj Preeth, Manickaraj Shairam, Dhanasekaran Anuradha
In the recent decades, flavonoid metal complexes have been widely investigated for their multifaceted role in enabling osteoblast differentiation and bone formation. Silibinin complexed with copper(II) ion has been synthesized along with two mixed ligand complexes, namely copper(II) silibinin-phenanthroline and neocuproine as co-ligands, and their positive role in promoting neovacularization and osteoblast differentiation was investigated. Silibinin mono complex [Cu(sil)(H2 O)2 ] and [Cu(sil)(phen)] showed similar UV-visible absorption in the region of 315 and 222 nm, whereas Cu(silibinin)(neocuproine) [Cu(sil)(neo)] showed a blueshift in the 320 nm transition...
May 19, 2018: Journal of Biological Inorganic Chemistry: JBIC
https://www.readbyqxmd.com/read/29779060/three-way-dna-junction-based-platform-for-ultra-sensitive-fluorometric-detection-of-multiple-metal-ions-as-exemplified-for-cu-ii-mg-ii-and-pb-ii
#4
Wen Yun, Xiaoqing Du, Junsheng Liao, Ge Sang, Lin Chen, Ning Li, Lizhu Yang
A DNA-based fluorometric method is described for simultaneous determination of multiple metal ions. It is based on recycling cleavage of hairpins by using a three-way DNA junction structure. Three DNA sequences containing a binding region and an enzyme-strand (E-DNA) region are hybridized to form a three-way DNA junction. The enzyme strand regions at the end of the DNA sequence binds to the substrate sequence (S-DNA) at the loop of the hairpin to form typical DNAzyme structures. In the presence of analyte metal ions, the DNAzyme structure thus formed cleaves the loop of hairpins...
May 20, 2018: Mikrochimica Acta
https://www.readbyqxmd.com/read/29778981/walking-the-line-the-fate-of-nanomaterials-at-biological-barriers
#5
REVIEW
Huan Meng, Wei Leong, Kam W Leong, Chunying Chen, Yuliang Zhao
Biological systems have developed an efficient multi-tiered defense system to block foreign substances such as engineered nanomaterials (NMs) from causing damage. In a pathological scenario, the disease itself may also pose additional barriers due to the imbalance between abnormal cells and their surrounding microenvironment, and NMs could behave similarly or differently to classic foreign substances, depending on their unique characteristics. Thus, understanding the mechanisms that govern the fate of NMs against these biological barriers, including the strategies that can be used to shift their fate between access and blockage, become key information for NMs design...
May 5, 2018: Biomaterials
https://www.readbyqxmd.com/read/29778960/rapid-colorimetric-detection-of-p53-protein-function-using-dna-gold-nanoconjugates-with-applications-for-drug-discovery-and-cancer-diagnostics
#6
Enock Assah, Walter Goh, Xin Ting Zheng, Ting Xiang Lim, Jun Li, David Lane, Farid Ghadessy, Yen Nee Tan
The tumor suppressor protein p53 plays a central role in preventing cancer through interaction with DNA response elements (REs) to regulate target gene expression in cells. Due to its significance in cancer biology, relentless efforts have been directed toward understanding p53-DNA interactions for the development of cancer therapeutics and diagnostics. In this paper, we report a rapid, label-free and versatile colorimetric assay to detect wildtype p53 DNA-binding function in complex solutions. The assay design is based on a concept that alters interparticle-distances between RE-AuNPs from a crosslinking effect induced through tetramerization of wildtype p53 protein (p53-WT) upon binding to canonical DNA motifs modified on gold nanoparticles (RE-AuNPs)...
May 5, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29778894/new-n-phenylpyrrolamide-dna-gyrase-b-inhibitors-optimization-of-efficacy-and-antibacterial-activity
#7
Martina Durcik, Denise Lovison, Žiga Skok, Cristina Durante Cruz, Päivi Tammela, Tihomir Tomašič, Davide Benedetto Tiz, Gábor Draskovits, Ákos Nyerges, Csaba Pál, Janez Ilaš, Lucija Peterlin Mašič, Danijel Kikelj, Nace Zidar
The ATP binding site located on the subunit B of DNA gyrase is an attractive target for the development of new antibacterial agents. In recent decades, several small-molecule inhibitor classes have been discovered but none has so far reached the market. We present here the discovery of a promising new series of N-phenylpyrrolamides with low nanomolar IC50 values against DNA gyrase, and submicromolar IC50 values against topoisomerase IV from Escherichia coli and Staphylococcus aureus. The most potent compound in the series has an IC50 value of 13 nM against E...
May 10, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29778893/synthesis-of-proline-derived-benzenesulfonamides-a-potent-anti-trypanosoma-brucei-gambiense-agent
#8
David I Ugwu, Uchechukwu C Okoro, Narendra K Mishra
Thousands of death in Africa and other developing nations are still attributed to trypanosomiasis. Excessive sleep has been associated with increased inflammation. We report herein, the synthesis, antitrypanosomal and anti-inflammatory activities of eight new carboxamide derivatives bearing substituted benzenesulfonamides. The base promoted reactions of l-proline and L-4-hydroxyproline with substituted benzenesulfonyl chlorides gave the benzenesulfonamides (11a-h) in excellent yields. Boric acid mediated amidation of the benzenesulfonamides (11a-h) and p-aminobenzoic acid (12) gave the new carboxamides (13a-h) in excellent yields...
May 14, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29778892/structure-based-design-of-novel-quinoxaline-2-carboxylic-acids-and-analogues-as-pim-1-inhibitors
#9
Bruno Oyallon, Marie Brachet-Botineau, Cédric Logé, Pascal Bonnet, Mohamed Souab, Thomas Robert, Sandrine Ruchaud, Stéphane Bach, Pascal Berthelot, Fabrice Gouilleux, Marie-Claude Viaud-Massuard, Caroline Denevault-Sabourin
We identified a new series of quinoxaline-2-carboxylic acid derivatives, targeting the human proviral integration site for Moloney murine leukemia virus-1 (HsPim-1) kinase. Seventeen analogues were synthesized providing useful insight into structure-activity relationships studied. Docking studies realized in the ATP pocket of HsPim-1 are consistent with an unclassical binding mode of these inhibitors. The lead compound 1 was able to block HsPim-1 enzymatic activity at nanomolar concentrations (IC50 of 74 nM), with a good selectivity profile against a panel of mammalian protein kinases...
May 11, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29778880/cellulose-hydrogel-with-tunable-shape-and-mechanical-properties-from-rigid-cylinder-to-soft-scaffold
#10
Noriyuki Isobe, Takehiro Komamiya, Satoshi Kimura, Ung-Jin Kim, Masahisa Wada
Cellulose hydrogel from aqueous solution of lithium bromide demonstrated excellent tunability of mechanical property and shape. A series of compression tests showed that cellulose hydrogel covered a wide range of mechanical property, where the compressive Young's modulus was controllable from 30 kPa to 1.3 MPa by changing the initial concentration of cellulose solution. Meanwhile, the diameter of the building block of gel, namely nano-fibrous cellulose, was constant at 15-20 nm irrelevant of the initial concentration of cellulose solution...
May 17, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29778879/preferential-binding-to-zinc-oxide-nanoparticle-interface-inhibits-lysozyme-fibrillation-and-cytotoxicity
#11
Kanti K Yadav, Manoranjan Arakha, Basudeb Das, Bibekanand Mallick, Suman Jha
The aim of present investigation is to explore the effect of zinc oxide nanoparticles (ZnONP, 30 nm) interface on conformational dynamics and stability of lysozyme, at pH 7.4 and pH 9.0. Lysozyme adopts partially disordered conformation at pH 9.0, which adopts fibril morphology in presence of sodium dodecyl sulfate (SDS), compared to the conformation adopted at pH 7.4. However, the presence of ZnONP interface renders partially disordered lysozyme relatively regular and non-amyloidogenic conformation, and enhances the functional efficacy of lysozyme at pH 9...
May 17, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29778875/purification-of-recombinant-trichodysplasia-spinulosa-associated-polyomavirus-vp1-derived-virus-like-particles-using-chromatographic-techniques
#12
Mindaugas Zaveckas, Karolis Goda, Danguole Ziogiene, Alma Gedvilaite
Trichodysplasia spinulosa-associated polyomavirus (TSPyV) has been linked to a rare and recently characterized skin disease occurring in immunocompromised patients. In analogy with other polyomaviruses, the major capsid protein VP1 of TSPyV can self-assemble into virus-like particles (VLPs). VLPs are increasingly applied for the vaccination and diagnostics. Mostly, non-scalable and labor intensive ultracentrifugation-based techniques are used for the purification of VLPs. In this work, we developed a purification procedure for TSPyV VP1 VLPs based on two chromatographic steps, ion-exchange monolith and core bead chromatography...
May 9, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29778873/bioanalysis-of-ibrutinib-and-its-dihydrodiol-and-glutathione-cycle-metabolites-by-liquid-chromatography-tandem-mass-spectrometry
#13
J J M Rood, P J A Dormans, M J van Haren, J H M Schellens, J H Beijnen, R W Sparidans
Ibrutinib is a targeted covalent inhibitor frequently used for the treatment of various lymphomas. In addition to oxidative metabolism, it is metabolized through glutathione coupling. The quantitative insight into this kind of metabolism is scarce, and tools for quantitation are lacking. The non-oxidative metabolism could prove a more prominent role when oxidative metabolism is impaired. Also, in-vitro studies could over-estimate the effect of CYP450-inhibition. To gain quantitative insight into this relatively unknown biotransformation pathway of the drug we have developed a validated simple, fast and sensitive bio-analytical assay for ibrutinib, dihydrodiol-ibrutinib, and the glutathione, cysteinylglycine and cysteine conjugates of ibrutinib in human plasma...
May 11, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29778782/acyclovir-lipid-nanocapsules-gel-for-oromucosal-delivery-a-preclinical-evidence-of-efficacy-in-the-chicken-pouch-membrane-model
#14
Darine Abozaid, Alyaa Ramadan, Heba Barakat, Nawal Khalafallah
The study aimed to develop a patient-friendly acyclovir gel with improved efficacy in viral mouth infections, in response to patients' need for an intraoral acyclovir product. Acyclovir was loaded in lipid nanocapsules in gel form, and formulae were evaluated for oromucosal delivery. Lipid nanocapsules were prepared by the phase inversion method. Formulae were optimized to achieve maximum acyclovir entrapment and minimum acyclovir precipitation. Colloidal properties, and pharmaceutical performance indicators were assessed...
May 17, 2018: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29778720/inflammatory-response-following-in-vitro-exposure-to-methylmercury-with-and-without-n-3-long-chain-polyunsaturated-fatty-acids-in-peripheral-blood-mononuclear-cells-from-systemic-lupus-erythematosus-patients-compared-to-healthy-controls
#15
William Crowe, Philip J Allsopp, Jennifer F Nyland, Pamela J Magee, J J Strain, Leanne C Doherty, Gene E Watson, Elisabeth Ball, Claire Riddell, David J Armstrong, Kayla Penta, Joshua J Todd, Toni Spence, Emeir M McSorley
Methylmercury (MeHg) is a proposed environmental stimulus in systemic lupus erythematosus (SLE). Humans are primarily exposed to MeHg through fish consumption. Fish are also important sources of n-3 long chain polyunsaturated fatty acids (n-3 LCPUFA). This in vitro study investigated the inflammatory response of isolated peripheral blood mononuclear cells (PBMCs), when exposed to either MeHg alone or with added n-3 LCPUFA, from SLE patients (N = 12) compared to healthy sex matched controls (N = 12)...
May 17, 2018: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/29778709/a-novel-and-simple-deep-eutectic-solvent-based-liquid-phase-microextraction-method-for-rhodamine-b-in-cosmetic-products-and-water-samples-prior-to-its-spectrophotometric-determination
#16
Erkan Yilmaz, Mustafa Soylak
A novel and green deep eutectic solvent based liquid phase microextraction (DES-LPME) methodology has been proposed for the assessment of rhodamine B from cosmetic products and water samples. A deep eutectic solvent (DES) consist of tetrabutyl ammonium chloride-decanoic acid (1:2) as extraction solvent and tetrahydrofuran as emulsification agent were used for the microextraction of rhodamine B. The quantitative recoveries were achieved at pH 3 by using 0.3 mL of DES and 0.3 mL of THF. The rhodamine B concentration in last volume was analyzed by mirco-cuvette UV-VIS spectrophotometer at 550 nm...
May 9, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29778708/fluorescence-resonance-energy-transfer-of-caf-2-eu-2-tb-3-applied-to-dye-sensitized-solar-cells
#17
Lege Wang, Zijian Yang, You-Fen Li, Ru Yang, Zhigang Dai, Shuqiao Hu, Liangliang Sun, Yaoyao Tong
CaF2 : Eu2+ , Tb3+ introduced into dye-sensitized solar cells (DSSCs) were studied to examine the influence of luminescent materials on photoanodes using a simple method. The emission spectra of CaF2 : Eu2+ , Tb3+ included the blue light of Eu2+ (4f → 5d) at 430 nm and green emission of Tb3+ (5 D4  → 7 F5 ) at 542 nm under the monitoring wavelengths at 398 nm, which matched well the absorption range of the N719 dye in DSSCs. Energy transfer (ET) was verified between Eu2+ and Tb3+ ions and the efficiency of ET found to increase with Tb3+ concentration...
May 4, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29778706/validated-stability-indicating-spectrophotometric-methods-for-the-determination-of-silodosin-in-the-presence-of-its-degradation-products
#18
Shereen A Boltia, Mohammed Abdelkawy, Taghreed A Mohammed, Nahla N Mostafa
Five simple, rapid, accurate, and precise spectrophotometric methods are developed for the determination of Silodosin (SLD) in the presence of its acid induced and oxidative induced degradation products. Method A is based on dual wavelength (DW) method; two wavelengths are selected at which the absorbance of the oxidative induced degradation product is the same, so wavelengths 352 and 377 nm are used to determine SLD in the presence of its oxidative induced degradation product. Method B depends on induced dual wavelength theory (IDW), which is based on selecting two wavelengths on the zero-order spectrum of SLD where the difference in absorbance between them for the spectrum of acid induced degradation products is not equal to zero so through multiplying by the equality factor, the absorption difference is made to be zero for the acid induced degradation product while it is still significant for SLD...
April 24, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29778703/sequential-injection-analysis-for-the-determination-of-fluoroquinolone-antibacterial-drug-residues-by-using-eosin-y-as-complexing-agent
#19
Kanokwan Chaiyasing, Boonsom Liawruangrath, Surapol Natakankitkul, Sakchai Satienperakul, Narabhats Rannurags, Poachanee Norfun, Saisunee Liawruangrath
A sequential injection analysis (SIA) method was developed for the rapid and sensitive determination of fluoroquinolone residues, including norfloxacin, ciprofloxacin and enrofloxacin, in fish samples. The method is based on the reaction between fluoroquinolone drug and eosin Y in Britton-Robinson buffer (pH 2.0), forming pink colored complexs with maximum absorptions at 522, 525 and 527 nm for norfloxacin, ciprofloxacin and enrofloxacin, respectively. Linearity ranges were found to be 0.05-10.0 mg L-1 (r2  = 0...
May 9, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29778679/efficient-metal-adsorption-and-microbial-reduction-from-rawal-lake-wastewater-using-metal-nanoparticle-coated-cotton
#20
Attarad Ali, Ayesha Gul, Abdul Mannan, Muhammad Zia
This study was designed to investigate removal of toxic metals and reduction of bacterial count from Rawal Lake wastewater with novel nanocomposite sorbents. Iron, zinc and silver oxide nanoparticles (NPs) were attached on cotton. The nanocomposites (iron NPs on cotton (FeCt), zinc NPs on cotton (ZnCt) and silver NPs on cotton (AgCt)) were characterized by FTIR, XRD and SEM, which showed successful adsorption of 10-30 nm size nanoparticles. Batch experiments were performed to determine the adsorption capacity of nanocomposite for metal removal...
May 17, 2018: Science of the Total Environment
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