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https://www.readbyqxmd.com/read/28945015/membrane-fusion-mediated-intracellular-delivery-of-lipid-bilayer-coated-mesoporous-silica-nanoparticles
#1
Jian Yang, Jing Tu, Gerda E M Lamers, René C L Olsthoorn, Alexander Kros
Protein delivery into the cytosol of cells is a challenging topic in the field of nanomedicine, because cellular uptake and endosomal escape are typically inefficient, hampering clinical applications. In this contribution cuboidal mesoporous silica nanoparticles (MSNs) containing disk-shaped cavities with a large pore diameter (10 nm) are studied as a protein delivery vehicle using cytochrome-c (cytC) as a model membrane-impermeable protein. To ensure colloidal stability, the MSNs are coated with a fusogenic lipid bilayer (LB) and cellular uptake is induced by a complementary pair of coiled-coil (CC) lipopeptides...
September 25, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28944964/wnt-%C3%AE-catenin-and-erk-pathway-activation-a-possible-mechanism-of-photobiomodulation-therapy-with-light-emitting-diodes-that-regulate-the-proliferation-of-human-outer-root-sheath-cells
#2
Jung E Kim, Young J Woo, Ki M Sohn, Kwan H Jeong, Hoon Kang
BACKGROUND: Outer root sheath cells (ORSCs) play important roles in maintaining hair follicle structure and provide support for the bulge area. The hair growth promoting effects of photobiomodulation therapy (PBMT) have been reported, but the mechanisms for this in human ORCs (hORSCs) have rarely been studied. OBJECTIVE: The aim of this study was to investigate the effect of various wavelengths of light-emitting diode (LED) irradiation on human ORSCs (hORSCs). METHODS: LED irradiation effects on hORSC proliferation and migration were examined with MTT assay, BrdU incorporation assay and migration assays...
September 25, 2017: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/28944814/one-step-detonation-assisted-synthesis-of-fe3o4-fe-bcnt-composite-towards-high-performance-lithium-ion-batteries
#3
Liyong Du, Chunxiao Xu, Jianjun Liu, Yazhu Lan, Pengwan Chen
An Fe3O4-Fe@BCNT composite was successfully synthesized via detonation of a mixture of hexogen (C3H6N6O6) and ferrocene (C10H10Fe), in which bamboo-like carbon nanotubes encapsulating iron nanoparticles attached to Fe3O4 flakes (up to 58.1%) were formed. In the detonation process, hexogen was used to generate high temperature and high pressure, while ferrocene was used as a carbon source and catalyst. The recovered Fe3O4-Fe@BCNT composite was characterized by TEM, SEM, XRD, XPS, and Raman spectroscopy. The results indicate that multi-walled carbon tubes with a bamboo-like structure are formed, in which iron nanoparticles are encapsulated...
September 25, 2017: Nanoscale
https://www.readbyqxmd.com/read/28944809/plasmonic-sensor-with-high-figure-of-merit-based-on-differential-polarization-spectra-of-elliptical-nanohole-array
#4
Bin Ai, Pradip Basnet, Steven Larson, Whitney Ingram, Yiping Zhao
Using the difference of the polarization transmission spectra of elliptical nanohole arrays (ENAs), the figure of merit (FOM) of the sensor performance of ENA can be significantly improved, and is inversely proportional to the measurement resolution. By optimizing the aspect ratio of the elliptical holes, Ag thickness, substrate-effect, and adhesive layer, the sensitivity, FOM, and relative sensitivity of the ENA can be improved to be 775 nm RIU(-1), 705 RIU(-1), and 70.23%, respectively, with an excellent linear dependence on the change of refractive index...
September 25, 2017: Nanoscale
https://www.readbyqxmd.com/read/28944766/magnesium-oxide-nanoparticle-loaded-polycaprolactone-composite-electrospun-fiber-scaffolds-for-bone-soft-tissue-engineering-applications-in-vitro-and-in-vivo-evaluation
#5
Ajay Suryavanshi, Kunal Khanna, K R Sindhu, Jayesh Bellare, Rohit Srivastava
The objective of the present investigation was to assess the potential of magnesium oxide nanoparticle (MgO NP)-loaded electrospun polycaprolactone (PCL) polymer composites as a bone-soft tissue engineering scaffold. MgO NPs were synthesized using a hydroxide precipitation sol-gel method and characterized using field emission gun-scanning electron microscopy/energy-dispersive x-ray spectroscopy (FEG-SEM/EDS), field emission gun-transmission electron microscopy (FEG-TEM), and x-ray diffraction (XRD) analysis...
September 25, 2017: Biomedical Materials
https://www.readbyqxmd.com/read/28944664/hemiindigo-highly-bistable-photoswitching-at-the-biooptical-window
#6
Christian Petermayer, Stefan Thumser, Florian Kink, Peter Mayer, Henry Dube
Hemiindigo is a long known chromophore that absorbs in the blue part of the spectrum but has almost completely been ignored as potential photoswitch. Herein we show how the absorption of hemiindigo is shifted to the red part of the visible spectrum and how nearly perfect photoswitching can be achieved using blue or green and red light. Five derivatives were investigated giving very high isomeric yields in both switching directions, i.e. >90% E isomer after irradiation with 470 to 530 nm light and 99% Z isomer with 590 up to 680 nm light...
September 25, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28944661/tempo-conjugated-gold-nanoparticles-for-reactive-oxygen-species-scavenging-and-regulation-of-stem-cell-differentiation
#7
Jingchao Li, Jing Zhang, Ying Chen, Naoki Kawazoe, Guoping Chen
Controlling the differentiation of human mesenchymal stem cells (hMSCs) shows a great potential in regenerative medicine. Because overproduced reactive oxygen species (ROS) have obvious inhibitory effect on the differentiation and functions of hMSCs, it is highly desirable to develop effective strategy for ROS scavenging and stem cell differentiation controlling. In this study, gold nanoparticles (Au NPs) with an average size of 40 nm were conjugated with 2,2,6,6-tetramethylpiperidine-N-oxyl (TEMPO) to endow them with ROS scavenging capacity while holding the beneficial effect of Au NPs...
September 25, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28944657/wetting-regimes-for-residual-layer-free-transfer-molding-at-the-micro-and-nanoscale
#8
Michael Deagen, Linda S Schadler, Chaitanya K Ullal
Transfer molding offers a low-cost approach to large-area fabrication of isolated structures in a variety of materials when recessed features of the open-faced mold are filled without leaving a residual layer on the plateaus of the mold. Considering both macroscale dewetting and microscale capillary flow, a proposed map of wetting regimes for blade meniscus coating provides a guide for achieving discontinuous dewetting at maximum throughput. Dependence of meniscus morphology on the azimuthal orientation of the stamp provides insight into the dominant mechanisms for discontinuous dewetting of 1-D patterns...
September 25, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28944635/-unknown-title
#9
(no author information available yet)
The use of a Nursing Model (NM) for nursing administration offers direct and indirect benefits for patients as for nurses. Depending the chosen NM, the concepts of person, health, nursing and environment are very different. Each NM has its special vision of the practice of nursing. The study investigated whether the Chief Nursing Officers (CNO) of the bilingual and French speaking Belgian hospitals integrate Nursing Models in the politics of their department. A quantitative descriptive and correlational survey was conducted...
August 17, 2017: Recherche en Soins Infirmiers
https://www.readbyqxmd.com/read/28944578/impact-of-a-central-scaffold-on-the-binding-affinity-of-fragment-pairs-isolated-from-dna-encoded-self-assembling-chemical-libraries
#10
Martina Bigatti, Alberto Dal Corso, Sara Vanetti, Samuele Cazzamalli, Ulrike Rieder, Jörg Scheuermann, Dario Neri, Filippo Sladojevich
The screening of encoded self-assembling chemical libraries allows the identification of fragment pairs that bind to adjacent pockets on target proteins of interest. For practical applications, it is necessary to link these ligand pairs into discrete organic molecules, devoid of any nucleic acid component. Here we describe the discovery of a synergistic binding pair for acid alpha-1 glycoprotein and a chemical strategy for the identification of optimal linkers, connecting the two fragments. The procedure yielded a set of small organic ligands, the best of which exhibited a dissociation constant of 9...
September 24, 2017: ChemMedChem
https://www.readbyqxmd.com/read/28944566/design-and-synthesis-of-a-highly-selective-jak3-inhibitor-for-the-treatment-of-rheumatoid-arthritis
#11
Linhong He, Heying Pei, Tingxuan Lan, Minghai Tang, Chufeng Zhang, Lijuan Chen
Selective inhibition of Janus kinase 3 (JAK3) has been identified as an important strategy for the treatment of autoimmune disorders. Based on the unique cysteine 909 residue (Cys909) of JAK3 at the gatekeeper position, we have developed a new irreversible covalent inhibitor, III-4, which is highly potent and selective in targeting JAK3. Importantly, III-4 selectively inhibited JAK3 (IC50  = 57 ± 1.21 nM) over other JAKs (IC50  > 10 µM) and Cys909 kinome members (IC50  > 1 µM)...
September 25, 2017: Archiv der Pharmazie
https://www.readbyqxmd.com/read/28944565/novel-tetrahydroacridine-derivatives-with-iodobenzoic-acid-moiety-as-multifunctional-acetylcholinesterase-inhibitors
#12
Robert Skibiński, Kamila Czarnecka, Małgorzata Girek, Ireneusz Bilichowski, Nina Chufarova, Elżbieta Mikiciuk-Olasik, Paweł Szymański
New synthesized series of 9-amino-1,2,3,4-tetrahydroacridine derivatives with iodobenzoic acid moiety were studied for their inhibitory activity towards cholinesterase and against β-amyloid aggregation. All novel molecules 3a-3i interacted with both cholinesterases - acetylcholinesterase and butyrylcholinesterase, delivered nanomolar IC50 values. The structure-activity relationship showed that N-butyl moiety derivatives are stronger inhibitors towards AChE and BuChE than N-ethyl and N-propyl moieties compounds...
September 25, 2017: Chemical Biology & Drug Design
https://www.readbyqxmd.com/read/28944561/impact-of-persistent-and-non-persistent-generic-escherichia-coli-and-salmonella-sp-recovered-from-a-beef-packing-plant-on-biofilm-formation-by-e-coli-o157
#13
Jeyachchandran Visvalingam, Timothy C Ells, Xianqin Yang
AIMS: To examine the influence of meat plant E. coli and Salmonella sp. isolates on E. coli O157 biofilm formation. METHODS AND RESULTS: Biofilm formation was quantified by crystal violet staining (A570 nm ) and viable cell numbers for up to 6 days at 15°C. All five persistent E. coli genotypes formed strong biofilms when cultured alone or co-cultured with E. coli O157, with A570 nm values reaching ≥4.8 at day 4, while only two of five non-persistent genotypes formed such biofilms...
September 25, 2017: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/28944395/combined-measurement-of-directional-raman-scattering-and-surface-plasmon-polariton-cone-from-adsorbates-on-smooth-planar-gold-surfaces
#14
Charles K A Nyamekye, Stephen C Weibel, Jonathan M Bobbitt, Emily A Smith
Directional-surface-plasmon-coupled Raman scattering (directional RS) has the combined benefits of surface plasmon resonance and Raman spectroscopy, and provides the ability to measure adsorption and monolayer-sensitive chemical information. Directional RS is performed by optically coupling a 50 nm gold film to a Weierstrass prism in the Kretschmann configuration and scanning the angle of the incident laser under total internal reflection. The collected parameters on the prism side of the interface include a full surface-plasmon-polariton cone and the full Raman signal radiating from the cone as a function of incident angle...
September 25, 2017: Analyst
https://www.readbyqxmd.com/read/28944391/coherence-in-nonradiative-transitions-internal-conversion-in-rydberg-excited-n-methyl-and-n-ethyl-morpholine
#15
Yao Zhang, Hannes Jónsson, Peter M Weber
The survival of coherent wavepacket motion during internal conversions is observed in relatively large molecules, N-methyl morpholine and N-ethyl morpholine, where standard models imply fast decoherence in a statistical limit. Optical excitation in the region of 194 to 230 nm excites the molecule to 3s or 3p Rydberg states, launching a wavepacket motion in the umbrella mode of the tertiary amine chromophore. In the short wavelength range, <214 nm, the molecules are excited to the 3p Rydberg state, which decays by internal conversion on a time scale of about 100 fs to the lower-lying 3s Rydberg state...
September 25, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28944375/influence-of-different-calcium-phosphates-on-an-experimental-adhesive-resin
#16
Isadora Martini Garcia, Vicente Castelo Branco Leitune, Susana Maria Werner Samuel, Fabrício Mezzomo Collares
PURPOSE: To formulate adhesive resins with 2 wt% of hydroxyapatite (HAp), α-tricalcium phosphate (α-TCP), or octacalcium phosphate (OCP) and to compare these groups with an unfilled adhesive regarding the degree of conversion, polymerization rate, microshear bond strength and mineral deposition. MATERIALS AND METHODS: The experimental adhesive resin was formulated mixing 66.6 wt% bisphenol A glycol dimethacrylate (bis-GMA), 33.3 wt% 2-hydroxyethyl methacrylate (HEMA), and a photoinitiator system...
September 21, 2017: Journal of Adhesive Dentistry
https://www.readbyqxmd.com/read/28944309/particle-coatings-but-not-silver-ions-mediate-genotoxicity-of-ingested-silver-nanoparticles-in-a-mouse-model
#17
Sameera Nallanthighal, Cadia Chan, Dhruba J Bharali, Shaker A Mousa, Elizabeth Vásquez, Ramune Reliene
Incorporation of silver nanoparticles (AgNPs) in toothpaste, food containers, dietary supplements and other consumer products can result in oral exposure to AgNPs and/or silver ions (Ag(+)) released from the surface of AgNPs. To examine whether ingestion of AgNPs or Ag(+) results in genotoxic damage and whether AgNP coatings modulate the effect, we exposed mice orally to 20 nm citrate-coated AgNPs, polyvinylpyrrolidone (PVP)-coated AgNPs, silver acetate or respective vehicles at a 4 mg/kg dose (equivalent to 800x the EPA reference dose for Ag) for 7 days...
January 2017: NanoImpact
https://www.readbyqxmd.com/read/28944308/titanium-dioxide-nanoparticle-ingestion-alters-nutrient-absorption-in-an-in-vitro-model-of-the-small-intestine
#18
Zhongyuan Guo, Nicole J Martucci, Fabiola Moreno-Olivas, Elad Tako, Gretchen J Mahler
Ingestion of titanium dioxide (TiO2) nanoparticles from products such as agricultural chemicals, processed food, and nutritional supplements is nearly unavoidable. The gastrointestinal tract serves as a critical interface between the body and the external environment, and is the site of essential nutrient absorption. The goal of this study was to examine the effects of ingesting the 30 nm TiO2 nanoparticles with an in vitro cell culture model of the small intestinal epithelium, and to determine how acute or chronic exposure to nano-TiO2 influences intestinal barrier function, reactive oxygen species generation, proinflammatory signaling, nutrient absorption (iron, zinc, fatty acids), and brush border membrane enzyme function (intestinal alkaline phosphatase)...
January 2017: NanoImpact
https://www.readbyqxmd.com/read/28944287/detection-of-pentosidine-cross-links-in-cell-secreted-decellularized-matrices-using-time-resolved-fluorescence-spectroscopy
#19
Debika Mitra, Hussain Fatakdawala, Michael Nguyen-Truong, Amy Creecy, Jeffry Nyman, Laura Marcu, J Kent Leach
Hyperglycemia-mediated, nonenzymatic collagen cross-links such as pentosidine (PENT) can have deleterious effects on cellular interactions with the extracellular matrix (ECM). Present techniques to quantify PENT are limited, motivating the need for improved methods to study the accumulation and contribution of PENT toward diabetic clinical challenges such as impaired bone healing. Current methods for studying PENT are destructive, laborious, and frequently employ oversimplified collagen films that lack the complexity of the native ECM...
September 11, 2017: ACS Biomaterials Science & Engineering
https://www.readbyqxmd.com/read/28944279/imaging-subcellular-dynamics-with-fast-and-light-efficient-volumetrically-parallelized-microscopy
#20
Kevin M Dean, Philippe Roudot, Erik S Welf, Theresa Pohlkamp, Gerard Garrelts, Joachim Herz, Reto Fiolka
In fluorescence microscopy, the serial acquisition of 2D images to form a 3D volume limits the maximum imaging speed. This is particularly evident when imaging adherent cells in a light-sheet fluorescence microscopy format, as their elongated morphologies require ~200 image planes per image volume. Here, by illuminating the specimen with three light-sheets, each independently detected, we present a light-efficient, crosstalk free, and volumetrically parallelized 3D microscopy technique that is optimized for high-speed (up to 14 Hz) subcellular (300 nm lateral, 600 nm axial resolution) imaging of adherent cells...
February 20, 2017: Optica
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