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https://www.readbyqxmd.com/read/28538979/stanniocalcin-1-is-an-ocular-hypotensive-agent-and-a-downstream-effector-molecule-that-is-necessary-for-the-intraocular-pressure-lowering-effects-of-latanoprost
#1
Gavin W Roddy, Kimberly B Viker, Nelson S Winkler, Cindy K Bahler, Bradley H Holman, David Sheikh-Hamad, Uttio Roy Chowdhury, W Daniel Stamer, Michael P Fautsch
Purpose: To identify downstream signaling molecules through which intraocular pressure (IOP) is lowered following treatment with the prostaglandin analog latanoprost. Methods: Total RNA and protein isolated from primary human Schlemm's canal cells (n = 3) treated with latanoprost (free acid; 100 nM) were processed for quantitative PCR and Western blot analysis. IOP was evaluated in stanniocalcin-1 (STC-1-/-) and wild-type mice following treatment with latanoprost or Rho kinase inhibitor Y27632...
May 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28538693/preparation-characterization-and-antioxidant-activity-evaluation-of-liposomes-containing-water-soluble-hydroxytyrosol-from-olive
#2
Jiao-Jiao Yuan, Frank G F Qin, Jun-Ling Tu, Bing Li
Due to the multiple hydroxyl groups in its structure, hydroxytyrosol (HT) is very sensitive to air and light and has very strong instability and hydrophilicity that affect its biological activity. This study attempted to prepare liposomes containing water-soluble HT to improve the bioavailability and biocompatibility of the target drug. The preparation process factors (temperature, mass ratio of phospholipid (PL) and cholesterol (CH), Tween-80 volume, HT mass) were studied and response surface methodology (RSM) was applied to optimize the conditions...
May 24, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28538685/the-effect-of-leaf-stacking-on-leaf-reflectance-and-vegetation-indices-measured-by-contact-probe-during-the-season
#3
Eva Neuwirthová, Zuzana Lhotáková, Jana Albrechtová
The aims of the study were: (i) to compare leaf reflectance in visible (VIS) (400-700 nm), near-infrared (NIR) (740-1140 nm) and short-wave infrared (SWIR) (2000-2400 nm) spectral ranges measured monthly by a contact probe on a single leaf and a stack of five leaves (measurement setup (MS)) of two broadleaved tree species during the vegetative season; and (ii) to test if and how selected vegetation indices differ under these two MS. In VIS, the pigment-related spectral region, the effect of MS on reflectance was negligible...
May 24, 2017: Sensors
https://www.readbyqxmd.com/read/28538674/biosynthesis-of-zno-nanoparticles-by-a-new-pichia-kudriavzevii-yeast-strain-and-evaluation-of-their-antimicrobial-and-antioxidant-activities
#4
Amin Boroumand Moghaddam, Mona Moniri, Susan Azizi, Raha Abdul Rahim, Arbakariya Bin Ariff, Wan Zuhainis Saad, Farideh Namvar, Mohammad Navaderi
The potential ability of a new yeast strain, Pichia kudriavzevii, in the synthesis of zinc oxide nanoparticles (ZnO-NPs) through a green method was explored in this study. The effect of reaction time (12, 24 and 36 h) on the structure of the resulting ZnO nanoparticles was investigated. From the XRD and TEM results, the ZnO-NPs with a hexagonal wurtzite structure and a particle crystal size of ~10-61 nm was formed at different reaction times. Combing XRD, TEM, and PL results, it was revealed that the sample prepared at intermediate duration (24 h) has the most favorable nanosized structure with the lowest defect concentration...
May 24, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28538515/effect-of-exposure-to-short-wavelength-light-on-susceptibility-to-motion-sickness
#5
Kyungshil Kim, Kazumi Hirayama, Kazuki Yoshida, Rika Yano, Masayuki Abe, Mika Otsuki, Satoshi Sakuraba, Shinya Sakai
This randomized cross-over study tested the hypothesis that exposure to short-wavelength light induces symptoms of motion sickness (MS). The study participants were 28 healthy adults (14 women; mean age±SD, 25.96±3.11 years). Two stimuli oscillating within a range of 0.4-0.6 Hz were used to induce MS: a blue wave stimulus with short-wavelength light (460 nm) and a green wave stimulus with middle-wavelength light (555 nm). All participants were exposed to both stimuli throughout two separate periods...
May 19, 2017: Neuroreport
https://www.readbyqxmd.com/read/28538314/do-neuromuscular-dentistry-designed-mouthguards-enhance-dynamic-movement-ability-in-competitive-athletes
#6
Joshua A Cotter, Steve T Jamison, Sarah A Schloemer, Ajit M W Chaudhari
Cotter, JA, Jamison, ST, Schloemer, SA, and Chaudhari, AMW. Do neuromuscular dentistry-designed mouthguards enhance dynamic movement ability in competitive athletes? J Strength Cond Res 31(6): 1627-1635, 2017-The purpose of this study was to examine the effect of a neuromuscular dentistry-designed mouthguard (NMDD) on dynamic movement ability. Forty-two competitive athletes (8 women, 21.9 ± 2.9 years, 66.8 ± 18.8 kg, 1.68 ± 0.11 m; 34 men, 22.8 ± 4.8 years, 77.4 ± 12.7 kg, 1.78 ± 0.08 m) with greater than 2 years' experience in their designated sport were enrolled in the study...
June 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28538156/a-simple-marker-assisted-3d-nanometer-drift-correction-method-for-superresolution-microscopy
#7
Hongqiang Ma, Jianquan Xu, Jingyi Jin, Yi Huang, Yang Liu
High-precision fluorescence microscopy such as superresolution imaging or single-particle tracking often requires an online drift correction method to maintain the stability of the three-dimensional (3D) position of the sample at a nanometer precision throughout the entire data acquisition process. Current online drift correction methods require modification of the existing two-dimensional (2D) fluorescence microscope with additional optics and detectors, which can be cumbersome and limit its use in many biological laboratories...
May 23, 2017: Biophysical Journal
https://www.readbyqxmd.com/read/28538150/lanthanides-report-calcium-sensor-in-the-vestibule-of-ryanodine-receptor
#8
Sándor Sárközi, István Komáromi, István Jóna, János Almássy
Ca(2+) regulates ryanodine receptor's (RyR) activity through an activating and an inhibiting Ca(2+)-binding site located on the cytoplasmic side of the RyR channel. Their altered sensitivity plays an important role in the pathology of malignant hyperthermia and heart failure. We used lanthanide ions (Ln(3+)) as probes to investigate the Ca(2+) sensors of RyR, because they specifically bind to Ca(2+)-binding proteins and they are impermeable to the channel. Eu(3+)'s and Sm(3+)'s action was tested on single RyR1 channels reconstituted into planar lipid bilayers...
May 23, 2017: Biophysical Journal
https://www.readbyqxmd.com/read/28538092/discriminating-residue-substitutions-in-a-single-protein-molecule-using-a-sub-nanopore
#9
Zhuxin Dong, Eamonn Kennedy, Mohammad Hokmabadi, Gregory Timp
It is now possible to create, in a thin inorganic membrane, a single, sub-nanometer-diameter pore, i.e. a sub-nanopore, about the size of an amino acid residue. To explore the prospects for sequencing protein with it, measurements of the force and current were performed as two denatured histones, which differed by four amino acid residue substitutions, were impelled systematically through the sub-nanopore one-at-a-time using an atomic force microscope. The force measurements revealed that once the denatured protein, stabilized by sodium dodecyl sulfate (SDS), translocated through the sub-nanopore, a disproportionately large force was required to pull it back...
May 24, 2017: ACS Nano
https://www.readbyqxmd.com/read/28538080/formulation-and-characterization-of-lutetium-177-labeled-stannous-tin-colloid-for-radiosynovectomy
#10
Geetanjali Arora, Manoranjan Singh, Pragati Jha, Sarthak Tripathy, Chandrasekhar Bal, Anirban Mukherjee, Shamim A Shamim
OBJECTIVE: Easy large-scale production, easy availability, cost-effectiveness, long half-life, and favorable radiation characteristics have made lutetium-177 (Lu) a preferred radionuclide for use in therapy. Lutetium-177-labeled stannous (Lu-Sn) colloid particles were formulated for application in radiosynovectomy, followed by in-vitro and in-vivo characterization. METHODS: Stannous chloride (SnCl2) solution and Lu were heated together, the pH was adjusted, and the particles were recovered by centrifugation...
May 19, 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/28537927/wx-132-18b-a-novel-microtubule-inhibitor-exhibits-promising-anti-tumor-effects
#11
Fang Guan, Rui Ding, Qi Zhang, Wei Chen, Feifei Li, Long Long, Wei Li, Linna Li, Dexuan Yang, Lan Xie, Shoujun Yuan, Lili Wang
Cancer drug researchers have been seeking microtubule-inhibiting agents (MIAs) with higher bioactivity and lower toxicity than currently marketed drugs. WX-132-18B, a novel structural compound synthesized at our institute, specifically bound to the colchicine-binding site on tubulin rather than the vinblastine site, and concentration-dependently reduced microtubule content via depolymerization. It exhibited the same cellular phenotypic profiles as the classic MIAs (colchicine, vincristine, and taxol), including inducing cell cycle arrest at the G2/M phase, triggering tumor cell apoptosis, promoting nuclear membrane permeability, reducing mitochondrial membrane potential, and disrupting the redox system balance...
May 9, 2017: Oncotarget
https://www.readbyqxmd.com/read/28537878/biological-characterization-of-sn32976-a-selective-inhibitor-of-pi3k-and-mtor-with-preferential-activity-to-pi3k%C3%AE-in-comparison-to-established-pan-pi3k-inhibitors
#12
Gordon W Rewcastle, Sharada Kolekar, Christina M Buchanan, Swarna A Gamage, Anna C Giddens, Kit Y Tsang, Jackie D Kendall, Ripudaman Singh, Woo-Jeong Lee, Greg C Smith, Weiping Han, David J Matthews, William A Denny, Peter R Shepherd, Stephen M F Jamieson
Multiple therapeutic agents have been developed to target the phosphatidylinositol 3-kinase (PI3K) signaling pathway, which is frequently dysregulated in cancer promoting tumor growth and survival. These include pan PI3K inhibitors, which target class Ia PI3K isoforms and have largely shown limited single agent activity with narrow therapeutic windows in clinical trials. Here, we characterize SN32976, a novel pan PI3K inhibitor, for its biochemical potency against PI3K isoforms and mTOR, kinase selectivity, cellular activity, pharmacokinetics, pharmacodynamics and antitumor efficacy relative to five clinically-evaluated pan PI3K inhibitors: buparlisib, dactolisib, pictilisib, omipalisib and ZSTK474...
May 9, 2017: Oncotarget
https://www.readbyqxmd.com/read/28537735/improved-superresolution-imaging-using-telegraph-noise-in-organic-semiconductor-nanoparticles
#13
Yifei Jiang, Muskendol Novoa, Teeranan Nongnual, Rhonda Powell, Terri F Bruce, Jason D McNeill
Small semiconductor structures often exhibit "telegraph noise". If the number of charge carriers is small, then spontaneous changes in the number of carriers can lead to abrupt switching between two or more discrete levels, leading to burst noise or popcorn noise in transistors. We have observed similar behavior in the fluorescence of organic semiconductor nanoparticles, where typical carrier populations are often less than ~10 carriers per nanoparticle. Spontaneous changes in the number of charges results in abrupt switching between 2 or more fluorescence intensity levels, since the charges act as highly efficient fluorescence quenchers...
May 24, 2017: Nano Letters
https://www.readbyqxmd.com/read/28537728/antimalarial-inhibitors-targeting-serine-hydroxymethyltransferase-shmt-with-in-vivo-efficacy-and-analysis-of-their-binding-mode-based-on-x-ray-cocrystal-structures
#14
Geoffrey Schwertz, Matthias C Witschel, Matthias Rottmann, Roger Bonnert, Ubolsree Leartsakulpanich, Penchit Chitnumsub, Aritsara Jaruwat, Wanwipa Ittarat, Anja Schäfer, Raphael A Aponte, Susan A Charman, Karen L White, Abhijit Kundu, Surajit Sadhukhan, Mel Lloyd, Gail M Freiberg, Myron Srikumaran, Marc Siggel, Adrian Zwyssig, Pimchai Chaiyen, François Diederich
Target-based approaches towards new antimalarial treatments are highly valuable to prevent resistance development. We report several series of pyrazolopyran-based inhibitors targeting the enzyme serine hydroxymethyltransferase (SHMT), designed to improve microsomal metabolic stability and to identify suitable candidates for in vivo efficacy evaluation. The best ligands inhibited Plasmodium falciparum (Pf) and Arabidopsis thaliana (At) SHMT in target assays and PfNF54 strains in cell-based assays with values in the low nanomolar range (3...
May 24, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28537713/site-occupancy-preference-and-antithermal-quenching-of-the-bi-2-deep-red-emission-in-%C3%AE-ca2p2o7-bi-2
#15
Liyi Li, Jiangkun Cao, Bruno Viana, Shanhui Xu, Mingying Peng
The resistance to thermal quenching is an essential factor in evaluating the performance of luminescent materials for application in white light emitting diodes (WLEDs). In this work, we studied the site occupancy preference and thermal quenching of luminescence in β-Ca2P2O7:Bi(2+) red phosphor at low (10-300 K) and high temperatures (303-573 K). In β-Ca2P2O7, the host lattice has four different calcium sites, at which Bi(2+)dopant can be located. After comparing the change of bond energy when the Bi(2+) ions are incorporated into the four calcium sites, we found out that Bi(2+) would preferentially occupy the smaller energy variation sites Ci(2) and Ci(1) in this compound, which can be assigned to Bi(2) and Bi(1), respectively...
May 24, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28535540/development-of-a-synthetic-substrate-for-the-in-vitro-performance-testing-of-sunscreens
#16
Myriam Sohn, Camille Malburet, Laure Baptiste, Yvonne Prigl
PURPOSE: Polymethylmethacrylate (PMMA) plates generally used for the in vitro testing of sunscreens have failed to yield a satisfactory correlation between the sun protection factor (SPF) in vitro and that in vivo. In the present study, various polymers were investigated as alternative substrates to PMMA plates. PROCEDURES: In total, 14 polymers were tested in terms of ultraviolet (UV) transparency by transmission spectroscopy, and surface properties by contact angle measurement...
May 24, 2017: Skin Pharmacology and Physiology
https://www.readbyqxmd.com/read/28535356/one-dimensional-carrier-confinement-in-giant-cds-cdse-excitonic-nanoshells
#17
Natalia Razgoniaeva, Pavel Moroz, Mingrui Yang, Darya S Budkina, Holly Eckard, Marissa Augspurger, Dmitriy Khon, Alexander N Tarnovsky, Mikhail Zamkov
The emerging generation of quantum dot optoelectronic devices offers an appealing prospect of a size-tunable band gap. The confinement-enabled control over electronic properties, however, requires nanoparticles to be sufficiently small, which leads to a large area of inter-particle boundaries in a film. Such interfaces lead to a high density of surface traps which ultimately increase the electrical resistance of a solid. To address this issue, we have developed an inverse energy-gradient core/shell architecture supporting the quantum confinement in nanoparticles larger than the exciton Bohr radius...
May 23, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28535354/high-capacity-and-ultrafast-na-ion-storage-of-self-supported-3d-porous-antimony-persulfide-graphene-foam-architecture
#18
Yanying Lu, Ning Zhang, Shuang Jiang, Yudong Zhang, Meng Zhou, Zhanliang Tao, Lynden A Archer, Jun Chen
The key challenge for high performance sodium-ion batteries is the exploitation of appropriate electrode materials with long cycling stability and high rate capability. Here, we report Sb2S5 nanoparticles (~ 5 nm) uniformly encapsulated in three-dimensional (3D) porous graphene foam, which were fabricated by a facile hydrothermal co-assembly strategy, as a high-performance anode material for sodium-ion batteries. The as-prepared composite can be directly used as electrodes without adding binder or current collector, exhibiting outstanding electrochemical performance with high reversible capacity (845 mAh g-1 at 0...
May 23, 2017: Nano Letters
https://www.readbyqxmd.com/read/28535347/preparation-and-characterization-of-protein-loaded-electrospun-fiber-mat-and-its-release-kinetics
#19
Peng Wen, Yan Wen, Xiao Huang, Minhua Zong, Hong Wu
For the enhancement of protein's bioavailability, a specific delivery system was developed by coaxial electrospinning. Bovine serum albumin (BSA) was used as protein model and the core-sheath fiber mat was fabricated using sodium alginate as shell layer and the BSA-loaded chitosan nanoparticle that prepared previously as core layer. By optimizing electrospinning parameters, uniform fibers with diameters ranging from 200 nm to 600 nm were obtained, and transmission electron microscopy and confocal laser scanning microscopy revealed its core-sheath structure...
May 23, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28535344/clarifying-the-controversial-catalytic-performance-of-co-oh-2-and-co3o4-for-oxygen-reduction-evolution-reactions-toward-efficient-zn-air-batteries
#20
Zhishuang Song, Xiaopeng Han, Yida Deng, Naiqin Zhao, Wenbin Hu, Cheng Zhong
Cobalt-based nanomaterials have been widely studied as catalysts for the oxygen reduction reaction (ORR) and oxygen evolution reaction (OER) due to their remarkable bifunctional catalytic activity, low cost and easy available. However, controversial results concerning OER/ORR performance exist between different types of cobalt-based catalysts, especially for Co(OH)2 and Co3O4. To address this issue, we develop a facile electrochemical deposition method to grow Co(OH)2 directly on the skeleton of carbon cloth, and further Co3O4 was obtained by post thermal treatment...
May 23, 2017: ACS Applied Materials & Interfaces
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