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diabetes without nephropathy anemia

Marwa A Sabe, Brian Claggett, Emmanuel A Burdmann, Akshay S Desai, Peter Ivanovich, Reshma Kewalramani, Eldrin F Lewis, John J V McMurray, Kurt A Olson, Patrick Parfrey, Scott D Solomon, Marc A Pfeffer
BACKGROUND: Although clear evidence shows that chronic kidney disease is a predictor of cardiovascular events, death, and accelerated coronary artery disease (CAD) progression, it remains unknown whether CAD is a predictor of progression of chronic kidney disease to end-stage renal disease. We sought to assess whether CAD adds prognostic information to established predictors of progression to dialysis in patients with chronic kidney disease, diabetes, and anemia. METHODS AND RESULTS: Using the previously described Trial to Reduce Cardiovascular Events With Aranesp Therapy (TREAT) population, we compared baseline characteristics of patients with and without CAD...
April 2016: Journal of the American Heart Association
Monica Schaefer, Emily Littrell, Amina Khan, Mark E Patterson
BACKGROUND: Associations between sodium phosphate enemas and nephropathy have raised concerns about the safety of use as part of a bowel-cleansing regimen administered prior to colonoscopies. The objectives of this analysis are to evaluate the impact of sodium phosphate enema versus polyethylene glycol powder for oral solution (PEG) use prior to colonoscopy screening on estimated glomerular filtration rate (eGFR) decline in Veterans Affairs (VA) patients and identify other risk factors contributing to eGFR decline...
April 2016: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
Zih-Jie Sun, Yi-Ching Yang, Jin-Shang Wu, Ming-Cheng Wang, Chih-Jen Chang, Feng-Hwa Lu
BACKGROUND: Glomerular hyperfiltration is closely related to diabetes and may lead to subsequent nephropathy, but the association between glomerular hyperfiltration and prediabetic state is unclear. We examined the relationship of different glycemic statuses, including normal glucose tolerance (NGT), isolated impaired fasting glucose (IFG), impaired glucose tolerance (IGT) and newly diagnosed diabetes (NDD), with glomerular hyperfiltration. METHODS: This study included 12 833 subjects ≥20 years of age without a history of renal disease, cancer, moderate/severe anemia or diabetes and taking medications for hypertension, diabetes, hyperlipidemia or cardiovascular disease from National Cheng Kung University Hospital between January 2000 and August 2009...
August 2016: Nephrology, Dialysis, Transplantation
Said Alsidawi, Marian Couto, Angel López-Candales
We present a case of a 61 year old man who presented with a 3 week history of easy bruising and ecchymoses in both thighs and right arm without significant trauma. Physical exam was remarkable for oozing gums, diminished second heart sound, a systolic ejection murmur at the aortic position with radiation to carotids, and delayed pulses. Laboratories were remarkable for iron deficiency anemia. Echocardiogram was consistent with severe aortic stenosis. Colonoscopy revealed several arteriovenous malformations throughout the colon...
April 2015: Boletín de la Asociación Médica de Puerto Rico
Samuel Goussot, Christiane Mousson, Charles Guenancia, Karim Stamboul, Philippe Brunel, Damien Brunet, Claude Touzery, Yves Cottin, Marianne Zeller
Contrast-induced nephropathy (CIN) after percutaneous coronary intervention (PCI) for ST-segment elevation myocardial infarction (STEMI) is frequent and associated with long-term renal impairment and mortality. Early markers of CIN are needed to improve risk stratification. We aimed to assess whether N-terminal fragment of pro B-type natriuretic peptide (Nt-proBNP) could be associated with CIN. From the French regional RICO survey, all the consecutive patients who underwent primary PCI for STEMI, from January 1, 2001, to December 3, 2013, were included...
September 15, 2015: American Journal of Cardiology
R A Abellás-Sequeiros, S Raposeiras-Roubín, E Abu-Assi, V González-Salvado, D Iglesias-Álvarez, A Redondo-Diéguez, R González-Ferreiro, R Ocaranza-Sánchez, C Peña-Gil, J M García-Acuña, J R González-Juanatey
BACKGROUND: Nowadays, contrast-induced nephropathy (CIN) is the third cause of acquired acute renal impairment in hospital. CIN is related to increased in-hospital morbidity, mortality, costs of medical care, and long admissions. Because of this, we hypothesized it would be useful to determine the risk of CIN with scores such as the Mehran score. The aim of this study was to validate the Mehran score in a contemporary cohort of Spanish patients with acute coronary syndrome (ACS). METHODS: We assessed the calibration and discriminatory capacity of Mehran score to predict CIN in a cohort of 1520 patients with a definitive diagnosis of ACS and who underwent coronary angiography between March 2008 and June 2012...
March 2016: Journal of Cardiology
Sun Hee Kim, Kyung Ae Lee, Heung Yong Jin, Hong Sun Baek, Tae Sun Park
BACKGROUND: Anemia is associated with various poor clinical outcomes in chronic kidney disease patients. The aim of this study was to investigate the relationship between anemia and the initiation degree and time of dialysis in type 2 diabetic nephropathy patients. METHODS: This observational retrospective study included 130 type 2 diabetic nephropathy patients in Korea. The existence of anemia, the degree and time of dialysis initiation were reviewed. Clinical characteristics and variables were also compared...
June 2015: Diabetes & Metabolism Journal
Hiroshi Okada, Goji Hasegawa, Muhei Tanaka, Takafumi Osaka, Yayoi Shiotsu, Hiromichi Narumiya, Mamoru Inoue, Koji Nakano, Naoto Nakamura, Michiaki Fukui
AIMS: Anemia, which might contribute to pathogenesis of kidney dysfunction, is a common finding in patients with type 2 diabetes. The aim of this study was to investigate if hemoglobin concentration is associated with the degree of change in urinary albumin-creatinine ratio or the development of albuminuria in patients with type 2 diabetes. METHODS: We measured hemoglobin concentration in 470 (296 men and 174 women) consecutive type 2 diabetic patients without albuminuria...
2015: PloS One
Luca De Nicola, Michele Provenzano, Paolo Chiodini, Silvio Borrelli, Carlo Garofalo, Mario Pacilio, Maria Elena Liberti, Adelia Sagliocca, Giuseppe Conte, Roberto Minutolo
Primary kidney disease is suggested to affect renal prognosis of CKD patients; however, whether nephrology care modifies this association is unknown. We studied patients with CKD stage I-IV treated in a renal clinic and with established diagnosis of CKD cause to evaluate whether the risk of renal event (composite of end-stage renal disease and eGFR decline ≥ 40%) linked to the specific diagnosis is modified by the achievement or maintenance in the first year of nephrology care of therapeutic goals for hypertension (BP ≤ 130/80 mmHg in patients with proteinuria ≥ 1 50 mg/24h and/or diabetes and ≤ 140/90 in those with proteinuria <150 mg/24h and without diabetes) anemia (hemoglobin, Hb ≥ 11 g/dL), and proteinuria (≤ 0...
2015: PloS One
Mahboobeh Sadat Hosseini, Zohreh Rostami, Alireza Saadat, Sayyed Mehdi Saadatmand, Effat Naeimi
BACKGROUND: Although chronic kidney disease-induced anemia is more prevalent in patients with diabetes mellitus (DM), anemia is a common finding prior to manifestation of kidney disease. In presence of some risk factors at the time of diagnosing DM, microvascular complications must be considered. The effect of anemia as a risk factor on progression of DM complications is still unclear. OBJECTIVES: The aim of the study was to determine the prevalence of anemia and its association with microvascular complications in patients with type 2 DM...
July 2014: Nephro-urology Monthly
Kazuyoshi Okada, Mitsuru Yanai, Kazuhisa Takeuchi, Kazuhiro Matsuyama, Kosaku Nitta, Kenji Hayashi, Susumu Takahashi
BACKGROUND/AIMS: We examined sex differences in prevalence, progression, and improvement in early-stage chronic kidney disease (CKD). METHODS: We analyzed data from 533 participants who took 4 consecutive annual CKD detection tests. RESULTS: Urine albumin-creatinine ratio (ACR), estimated glomerular filtration rate (eGFR), and hemoglobin (Hb) at baseline in men with and without CKD and in women with and without CKD were 8.3±6.1, 149.2±310...
2014: Kidney & Blood Pressure Research
Hiroyuki Ito, Yuichiro Takeuchi, Hidenori Ishida, Aya Otawa, Akane Shibayama, Shinichi Antoku, Mariko Abe, Mizuo Mifune, Michiko Togane
UNLABELLED: Aims/Introduction:  The present study investigated the frequency of mild anemia, which is not an indication of intensive therapy using drugs, in Japanese patients with type 2 diabetes mellitus and the association of mild anemia with diabetic complications. MATERIALS AND METHODS:   This is a cross-sectional study of 1189 patients with type 2 diabetes mellitus. Anemia was defined as a hemoglobin level <13.5 g/dL in men and <12.0 g/dL in women...
December 3, 2010: Journal of Diabetes Investigation
Lavinia Oltiţa Brătescu, Liliana Bârsan, Liliana Gârneaţă, Ana Stanciu, Mariana Lipan, Simona Hildegard Stancu, Gabriel Mircescu
BACKGROUND: Serum hepcidin-25 is not only a marker of iron stores, but also an acute phase reactant, and it could fluctuate in response to erythropoietic activity. STUDY DESIGN: Prospective interventional, 3-months duration, investigating the influence of additional intravenous (IV) iron on hepcidin-25 in hemodialysis (HD) patients without obvious iron deficiency (ID). SETTINGS AND PARTICIPANTS: Single HD unit, 41 patients. MEASUREMENTS: Hepcidin-25 (ELISA method), ferritin, transferrin, transferrin saturation (TSAT), C-reactive protein and serum albumin--at baseline and assessment; hemoglobin, iron and darbepoetin doses--monthly...
May 2014: International Urology and Nephrology
Amy M Becker, Jordan H Goldberg, Michael Henson, Chul Ahn, Liyue Tong, Michel Baum, George R Buchanan
BACKGROUND: Kidney disease is an important cause of morbidity and mortality in patients with sickle cell anemia (SCA). The factors that affect progression of renal disease are unknown, especially in children and adolescents. Alterations in blood pressure, including hypertension and lack of the normal nocturnal dip in blood pressure, are important determinants of diabetic nephropathy and other renal diseases and may play a role in sickle cell nephropathy. Our primary hypothesis was that children with SCA who have microalbuminuria will demonstrate less nocturnal dipping of blood pressure compared to patients without microalbuminuria...
March 2014: Pediatric Blood & Cancer
Mohamed Akheel Ahmed, Githa Kishore, Hafeez Abdul Khader, Meera Neelathahalli Kasturirangan
To determine the risk factors for nephropathy in diabetic patients and to study the management of diabetic nephropathy (DN), we conducted a hospital-based prospective study in the Internal Medicine department of our hospital on 60 patients with DN and 60 diabetic patients without DN. An odds ratio (OR) disclosed the following risk factors: Hypertension (OR = 2.06), family history of diabetes (OR = 1.23), family history of DN (OR = 2.86), uncontrolled hyperglycemia (OR = 11.80), obesity (OR = 1.07), duration of diabetes between 11 and 20 years (OR = 4...
November 2013: Saudi Journal of Kidney Diseases and Transplantation
Chagai Grossman, Zamir Dovrish, Nira Koren-Morag, Gil Bornstein, Avshalom Leibowitz
BACKGROUND: Anaemia is a common complication of diabetes mellitus (DM), usually related to renal failure. There is scarce information as to the levels of haemoglobin (Hb) and the rate of anaemia in diabetic patients with normal renal function. We, therefore, evaluated haemoglobin levels and the rate of anaemia in diabetic subjects with normal renal functions [estimated glomerular filtration rate (eGFR) > 60 mL/min]. METHODS: The charts of 9250 subjects who attended the Institute of Periodic Medical Examinations at the Chaim Sheba Medical Center for a routine yearly check-up were reviewed...
May 2014: Diabetes/metabolism Research and Reviews
Saziye Sezin Palabiyik, Terken Baydar, Ramazan Cetinkaya, Anil Barak Dolgun, Gönül Sahin
The present study was aimed to evaluate erythrocyte folate and the iron levels in diabetes and hypertension patients treated with/without hemodialysis. The effects of erythropoietin and iron treatment as well as vitamin supplementation on measured parameters were considered. The 67 controls consisted of healthy subjects (n = 22), hypertensive subjects (n = 22), and diabetic subjects (n = 23) without any renal disorder. According to primary renal disorders, the patients undergoing hemodialysis (n = 68) were classified into four groups as diabetic nephropathy, hypertensive nephropathy, reflux nephropathy or interstitial nephritis, and renal insufficiency depending on other causative factors...
January 2014: Hemodialysis International
D Kundu, A Roy, T Mandal, U Bandyopadhyay, E Ghosh, D Ray
BACKGROUND: Nephropathy is one of the complications of type 2 diabetes mellitus that could lead to end-stage renal disease. Persistent microalbuminuria is the best predictor of high risk of developing diabetic nephropathy. The relation between HbA 1c and microalbuminuria with the duration of diabetes is not clear. OBJECTIVES: To determine microalbuminuria levels in type 2 diabetics and to correlate changes in microalbuminuria levels to glycosylated hemoglobin level and duration of diabetes...
April 2013: Nigerian Journal of Clinical Practice
Andreea Andronesi, Luminita Iliuta, Magdalena Patruleasa, Camelia Achim, Gener Ismail, Raluca Bobeica, Elena Rusu, Diana Zilisteanu, Danut Andronesi, Otilia Motoi, Alecse Ditoiu, Ionel Copaci, Mihai Voiculescu
OBJECTIVES: Scientific literature indicates that the risk of coronary heart disease morbidity and death among peritoneal dialysis patients exceeds risk observed in non-renal patients. The aims of this study were to establish the independent predictors associated with increased risk of coronary heart disease in peritoneal dialysis patients without diabetic nephropathy. MATERIALS AND METHODS: A number of 116 end-stage renal disease patients without diabetic nephropathy undergoing peritoneal dialysis were evaluated for coronary heart disease and predictive risk factors were investigated and identified...
September 2012: Mædica
Hisham Waggiallah, Mohammed Alzohairy
BACKGROUND: The oxidative stress is considered as major consequence of diabetes mellitus affecting red cell antioxidant enzymes AIM: The present study was conducted to assess the impact of oxidative stress (reduced glutathione) on glutathione peroxidase, and glutathione reductse and prevalence of anemia among diabetic patients. MATERIALS AND METHODS: The study involved 100 adult patients attending Buraidah Central Hospital and 30 healthy controls...
July 2011: North American Journal of Medical Sciences
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