keyword
https://read.qxmd.com/read/38536919/iterative-assay-for-transposase-accessible-chromatin-by-sequencing-to-isolate-functionally-relevant-neuronal-subtypes
#1
JOURNAL ARTICLE
Collin B Merrill, Iris Titos, Miguel A Pabon, Austin B Montgomery, Aylin R Rodan, Adrian Rothenfluh
The Drosophila brain contains tens of thousands of distinct cell types. Thousands of different transgenic lines reproducibly target specific neuron subsets, yet most still express in several cell types. Furthermore, most lines were developed without a priori knowledge of where the transgenes would be expressed. To aid in the development of cell type-specific tools for neuronal identification and manipulation, we developed an iterative assay for transposase-accessible chromatin (ATAC) approach. Open chromatin regions (OCRs) enriched in neurons, compared to whole bodies, drove transgene expression preferentially in subsets of neurons...
March 29, 2024: Science Advances
https://read.qxmd.com/read/38536868/the-social-determinants-of-migrant-domestic-worker-mdw-health-and-well-being-in-the-western-pacific-region-a-scoping-review
#2
JOURNAL ARTICLE
Jamie Chan, Georgia Dominguez, Antonia Hua, Melissa Garabiles, Carl A Latkin, Brian J Hall
The health and well-being of transnational migrant domestic workers (MDWs) is a pressing but largely neglected public health concern. The Asia Pacific region is home to over 20% of the global MDW population. Living and working conditions, social contexts, political environments, and migration regimes are recognized as consequential to the health of this population, but currently no synthesis of available literature to prioritize research or policy agenda setting for MDW has yet been conducted. This scoping review screened 6,006 peer-reviewed articles and 1,217 gray literature sources, identifying 173 articles and 276 gray literature sources that reported key MDW health outcomes, social determinants of health, and related interventions...
2024: PLOS Glob Public Health
https://read.qxmd.com/read/38536558/a-deep-learning-model-for-translating-ct-to-ventilation-imaging-analysis-of-accuracy-and-impact-on-functional-avoidance-radiotherapy-planning
#3
JOURNAL ARTICLE
Zhen Hou, Youyong Kong, Junxian Wu, Jiabing Gu, Juan Liu, Shanbao Gao, Yicai Yin, Ling Zhang, Yongchao Han, Jian Zhu, Shuangshuang Li
PURPOSE: Radiotherapy planning incorporating functional lung images has the potential to reduce pulmonary toxicity. Free-breathing 4DCT-derived ventilation image (CTVI) may help quantify lung function. This study introduces a novel deep-learning model directly translating planning CT images into CTVI. We investigated the accuracy of generated images and the impact on functional avoidance planning. MATERIALS AND METHODS: Paired planning CT and 4DCT scans from 48 patients with NSCLC were randomized to training (n = 41) and testing (n = 7) data sets...
March 27, 2024: Japanese Journal of Radiology
https://read.qxmd.com/read/38536494/the-role-of-na-coupled-bicarbonate-transporters-ncbt-in-health-and-disease
#4
REVIEW
Shannon R Holmberg, Yohei Sakamoto, Akira Kato, Michael F Romero
Cellular and organism survival depends upon the regulation of pH, which is regulated by highly specialized cell membrane transporters, the solute carriers (SLC) (For a comprehensive list of the solute carrier family members, see: https://www.bioparadigms.org/slc/ ). The SLC4 family of bicarbonate (HCO3 - ) transporters consists of ten members, sorted by their coupling to either sodium (NBCe1, NBCe2, NBCn1, NBCn2, NDCBE), chloride (AE1, AE2, AE3), or borate (BTR1). The ionic coupling of SLC4A9 (AE4) remains controversial...
March 27, 2024: Pflügers Archiv: European Journal of Physiology
https://read.qxmd.com/read/38536433/immobilised-antimicrobial-peptides-in-downregulation-of-biofilm
#5
REVIEW
Moupriya Nag, Debasmita Bhattacharya, Sayantani Garai, Bandita Dutta, Sreejita Ghosh, Rina Rani Ray, Dibyajit Lahiri
Colonisation of sessile bacterial species on biotic and abiotic surfaces is responsible for the development of various infections in humans. At present, biofilm-associated chronic infections have been a prime concern among the healthcare practitioners since they are impermeable to drugs, resulting in the development of antibiotic resistance or multi-drug resistance. For a few decades, a lot of research activity has been performed in the development of alternative therapeutics to combat biofilm-associated chronic infections...
March 27, 2024: Naunyn-Schmiedeberg's Archives of Pharmacology
https://read.qxmd.com/read/38536010/hydrophobic-functionalization-of-a-metal-organic-framework-as-an-ammonia-visual-sensing-material-under-high-humidity-conditions
#6
JOURNAL ARTICLE
Yuxin Wang, Zhengxuan Song, Yutao Liu, Yang Chen, Jinping Li, Libo Li, Jia Yao
Since exhaled ammonia (NH3 ) is one of the metabolic markers of liver and kidney diseases, ammonia visual sensing materials in humid environments have received extensive attention and investigation. Herein, through a tailor-made pore environment provided by metal-organic framework (MOF) materials (CH3 -Cu(BDC)), we achieved NH3 anti-interference sensing with apparent color changing under humid conditions. With methyl (CH3 -) functionalization, CH3 -Cu(BDC) demonstrated a strong response for trace ammonia and showed high selectivity under a humid environment...
March 27, 2024: Dalton Transactions: An International Journal of Inorganic Chemistry
https://read.qxmd.com/read/38535960/indoor-air-quality-and-bioaerosols-in-spanish-university-classrooms
#7
JOURNAL ARTICLE
Esther Fuentes-Ferragud, Antonio López, Juan Miguel Piera, Vicent Yusà, Salvador Garrigues, Miguel de la Guardia, F Xavier López Labrador, Marisa Camaró, María Ibáñez, Clara Coscollà
A comprehensive study assessed indoor air quality parameters, focusing on relevant air pollutants such as particulate matter (PM10 and PM2.5 ), gaseous compounds (CO, CO2 , formaldehyde, NO2 ) and volatile/semi-volatile organic chemicals, as well as respiratory viruses (including SARS-CoV-2), fungi and bacteria in Spanish university classrooms. Non-target screening strategies evaluated the presence of organic pollutants inside and outside the classrooms. Saliva samples from teachers and students were collected to explore correlations between respiratory viruses in the air and biological samples...
March 20, 2024: Toxics
https://read.qxmd.com/read/38535950/mechanism-of-the-synergistic-toxicity-of-ampicillin-and-cefazoline-on-selenastrum-capricornutum
#8
JOURNAL ARTICLE
Feng-Ling Huang, Li-Tang Qin, Ling-Yun Mo, Hong-Hu Zeng, Yan-Peng Liang
Ampicillin (AMP) and cefazolin (CZO) are commonly used β-lactam antibiotics which are extensively globally produced. Additionally, AMP and CZO are known to have relatively high ecotoxicity. Notably, the mix of AMP and CZO creates a synergistic effect that is more harmful to the environment, and how exposure to AMP-CZO can induce synergism in algae remains virtually unknown. To yield comprehensive mechanistic insights into chemical toxicity, including dose-response relationships and variations in species sensitivity, the integration of multiple endpoints with de novo transcriptomics analyses were used in this study...
March 14, 2024: Toxics
https://read.qxmd.com/read/38535911/behavioral-studies-of-zebrafish-reveal-a-new-perspective-on-the-reproductive-toxicity-of-micro-and-nanoplastics
#9
REVIEW
Baihui Wu, Haiyang Yu, Jia Yi, Pengyu Lei, Jiaxuan He, Jing Ruan, Peiye Xu, Runchao Tao, Libo Jin, Wei Wu, Qinsi Yang, Da Sun, Xiaoqun Zhang
The escalating prevalence of microplastics and nanoplastics in aquatic environments is a major challenge affecting the behavior and reproductive health of aquatic organisms while posing potential risks to human health and ecosystems. This review focuses on the neurobehavioral changes and reproductive toxicity of MNPs in zebrafish and their relationships. At the same time, the neurobehavioral changes caused by MNPs were studied, and the synergistic effects of the interaction of these pollutants with other environmental contaminants were explored...
February 26, 2024: Toxics
https://read.qxmd.com/read/38535815/integration-of-multi-omics-histological-and-biochemical-analysis-reveals-the-toxic-responses-of-nile-tilapia-liver-to-chronic-microcystin-lr-exposure
#10
JOURNAL ARTICLE
Yichao Li, Huici Yang, Bing Fu, Gen Kaneko, Hongyan Li, Jingjing Tian, Guangjun Wang, Mingken Wei, Jun Xie, Ermeng Yu
Microcystin-LR (MC-LR) is a cyanobacterial metabolite produced during cyanobacterial blooms and is toxic to aquatic animals, and the liver is the main targeted organ of MC-LR. To comprehensively understand the toxicity mechanism of chronic exposure to environmental levels of MC-LR on the liver of fish, juvenile Nile tilapia were exposed to 0 μg/L (control), 1 μg/L (M1), 3 μg/L (M3), 10 μg/L (M10), and 30 μg/L (M30) MC-LR for 60 days. Then, the liver hepatotoxicity induced by MC-LR exposure was systematically evaluated via histological and biochemical determinations, and the underlying mechanisms were explored through combining analysis of biochemical parameters, multi-omics (transcriptome and metabolome), and gene expression...
March 14, 2024: Toxins
https://read.qxmd.com/read/38535786/bee-venom-composition-and-anticancer-properties
#11
REVIEW
Goran Gajski, Elina Leonova, Nikolajs Sjakste
Among the various natural compounds used in alternative and Oriental medicine, toxins isolated from different organisms have had their application for many years, and Apis mellifera venom has been studied the most extensively. Numerous studies dealing with the positive assets of bee venom (BV) indicated its beneficial properties. The usage of bee products to prevent the occurrence of diseases and for their treatment is often referred to as apitherapy and is based mainly on the experience of the traditional system of medical practice in diverse ethnic communities...
February 29, 2024: Toxins
https://read.qxmd.com/read/38535779/screening-tlr4-binding-peptide-from-naja-atra-venom-glands-based-on-phage-display
#12
JOURNAL ARTICLE
Runhan Li, Yezhong Tang, Zening Chen, Yang Liu
Toll-like receptor 4 (TLR4) is a crucial inflammatory signaling pathway that can serve as a potential treatment target for various disorders. A number of inhibitors have been developed for the TLR4 pathway, and although no inhibitors have been approved for clinical use, most have been screened against the TLR4-MD2 conformation. The venom gland is the organ of venomous snakes that secretes substances that are toxic to other animals. The level of gene transcription in venom glands is different from that in other tissues, includes a large number of biologically active ingredients, and is an important natural resource for the development of new drugs...
February 24, 2024: Toxins
https://read.qxmd.com/read/38535718/dare-to-ask-a-model-for-teaching-nursing-students-about-identifying-and-responding-to-violence-against-women-and-domestic-violence
#13
JOURNAL ARTICLE
Leah Okenwa Emegwa, Stéphanie Paillard-Borg, Inger Wallin Lundell, Anna Stålberg, Maria Åling, Gabriella Ahlenius, Henrik Eriksson
The role of nurses in identifying and responding to family violence and violence against women has long been established. However, nurses' readiness to fully assume this role remains low due to various barriers and the sensitive nature of the subject. As part of capacity building to address this problem, an additional national qualitative learning target, i.e., to "show knowledge about men's violence against women and violence in close relationships", was introduced into the Swedish Higher Education Ordinance for nursing and seven other educational programs between 2017 and 2018...
March 10, 2024: Nursing Reports
https://read.qxmd.com/read/38535500/an-exploratory-investigation-of-organic-chemicals-detected-in-baby-teeth-differences-in-children-with-and-without-autism
#14
JOURNAL ARTICLE
Raymond F Palmer
Autism spectrum disorder (ASD) is a behaviorally defined neurodevelopmental disorder characterized by deficits in language, communication, and social function with an estimated prevalence rate of between 1 in 30 and 44 U.S. births. Gene/environment (G × E) interactions are widely regarded as the most probable explanation for idiopathic ASD, especially because some genes are selectively targeted by various environmental xenobiotics. Because deciduous teeth are a likely biomarker of in utero exposure, the present study investigated if the quantity of chemicals found in deciduous teeth differs between children with and without ASD...
March 14, 2024: Journal of Xenobiotics
https://read.qxmd.com/read/38535472/anti-inflammatory-activity-of-cyanobacteria-pigment-extracts-physiological-free-radical-scavenging-and-modulation-of-inos-and-lox-activity
#15
JOURNAL ARTICLE
Lécia Rodrigues, Janaína Morone, Guilherme Scotta Hentschke, Vitor Vasconcelos, Graciliana Lopes
Cyanobacteria are among the oldest organisms colonizing Earth. Their great biodiversity and ability to biosynthesize secondary metabolites through a variety of routes makes them attractive resources for biotechnological applications and drug discovery. In this pioneer study, four filamentous cyanobacteria ( Cephalothrix lacustris LEGE 15493, Leptolyngbya boryana LEGE 15486, Nodosilinea nodulosa LEGE 06104 and Leptothoe sp. LEGE 11479) were explored for their anti-inflammatory potential in cell and cell-free in vitro bioassays, involving different inflammatory mediators and enzymes...
March 12, 2024: Marine Drugs
https://read.qxmd.com/read/38535455/marine-derived-anticancer-agents-targeting-apoptotic-pathways-exploring-the-depths-for-novel-cancer-therapies
#16
REVIEW
Doralyn S Dalisay, Chuckcris P Tenebro, Edna M Sabido, Angelica Faith L Suarez, Melissa June V Paderog, Rikka Reyes-Salarda, Jonel P Saludes
Extensive research has been conducted on the isolation and study of bioactive compounds derived from marine sources. Several natural products have demonstrated potential as inducers of apoptosis and are currently under investigation in clinical trials. These marine-derived compounds selectively interact with extrinsic and intrinsic apoptotic pathways using a variety of molecular mechanisms, resulting in cell shrinkage, chromatin condensation, cytoplasmic blebs, apoptotic bodies, and phagocytosis by adjacent parenchymal cells, neoplastic cells, or macrophages...
February 28, 2024: Marine Drugs
https://read.qxmd.com/read/38535405/combinations-of-lemongrass-and-star-anise-essential-oils-and-their-main-constituent-synergistic-housefly-repellency-and-safety-against-non-target-organisms
#17
JOURNAL ARTICLE
Mayura Soonwera, Jirisuda Sinthusiri, Hataichanok Passara, Tanapoom Moungthipmalai, Cheepchanok Puwanard, Sirawut Sittichok, Kouhei Murata
The present study evaluated the housefly repellency of single-component formulations and combinations of lemongrass and star anise essential oils (EOs) and their main constituents. The efficacies of the combinations were compared against those of single-component formulations and DEET. Safety bioassays of all formulations and DEET on non-target species-guppy, molly, dwarf honeybee, and stingless bee-were conducted. GC-MS analysis showed that the main constituent of lemongrass EO was geranial (46.83%) and that of star anise EO was trans -anethole (92...
March 20, 2024: Insects
https://read.qxmd.com/read/38535401/-wolbachia-infection-through-hybridization-to-enhance-an-incompatible-insect-technique-based-suppression-of-aedes-albopictus-in-eastern-spain
#18
JOURNAL ARTICLE
Maria Cholvi, María Trelis, Rubén Bueno-Marí, Messaoud Khoubbane, Rosario Gil, Antonio Marcilla, Riccardo Moretti
The emergence of insecticide resistance in arbovirus vectors is putting the focus on the development of new strategies for control. In this regard, the exploitation of Wolbachia endosymbionts is receiving increasing attention due to its demonstrated effectiveness in reducing the vectorial capacity of Aedes mosquitoes. Here, we describe the establishment of a naïve Wolbachia infection in a wild Aedes albopictus population of eastern Spain through a hybridization approach to obtain males capable of sterilizing wild females...
March 20, 2024: Insects
https://read.qxmd.com/read/38535314/pesticides-unintended-impact-on-the-hidden-world-of-gut-microbiota
#19
REVIEW
Asghar Ali, Khalid I AlHussaini
A vast range of pesticides have been routinely employed for plant protection throughout the last few decades. Pesticides can enter non-target organisms in various ways, posing health hazards. Exposure to different environmental pollutants, including pesticides, can affect the human gut flora. Metabolites generated from the gut microbiota play an essential role in the host's health by regulating metabolic homeostasis. A disruption in this equilibrium can lead to the emergence of numerous illnesses and their etiology...
March 7, 2024: Metabolites
https://read.qxmd.com/read/38535289/an-untargeted-metabolomics-strategy-to-identify-substrates-of-known-and-orphan-e-coli-transporters
#20
JOURNAL ARTICLE
Mohammad S Radi, Lachlan J Munro, Daniela Rago, Douglas B Kell
Transport systems play a pivotal role in bacterial physiology and represent potential targets for medical and biotechnological applications. However, even in well-studied organisms like Escherichia coli , a notable proportion of transporters, exceeding as many as 30%, remain classified as orphans due to their lack of known substrates. This study leveraged high-resolution LC-MS-based untargeted metabolomics to identify candidate substrates for these orphan transporters. Human serum, including a diverse array of biologically relevant molecules, served as an unbiased source for substrate exposure...
March 20, 2024: Membranes
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