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https://www.readbyqxmd.com/read/29166661/ultraconserved-elements-uces-resolve-the-phylogeny-of-australasian-smurf-weevils
#1
Matthew H Van Dam, Athena W Lam, Katayo Sagata, Bradley Gewa, Raymond Laufa, Michael Balke, Brant C Faircloth, Alexander Riedel
Weevils (Curculionoidea) comprise one of the most diverse groups of organisms on earth. There is hardly a vascular plant or plant part without its own species of weevil feeding on it and weevil species diversity is greater than the number of fishes, birds, reptiles, amphibians and mammals combined. Here, we employ ultraconserved elements (UCEs) designed for beetles and a novel partitioning strategy of loci to help resolve phylogenetic relationships within the radiation of Australasian smurf-weevils (Eupholini)...
2017: PloS One
https://www.readbyqxmd.com/read/29166560/analytical-challenges-and-recent-advances-in-mass-spectrometry-based-lipidomics
#2
Yepy Hardi Rustam, Gavin Edmund Reid
Although no internationally accepted consensus definition exists, lipids can be broadly defined as "fatty acids and their derivatives, and substances related biosynthetically or functionally to these compounds". Lipids play critical roles as (i) the major structural components of biological membranes, and as functional and regulatory components of membrane protein signaling, (ii) bioactive intra- and inter-cellular signaling molecules, and (iii) energy storage molecules for the maintenance of energy homeostasis...
November 22, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/29166426/rhinology-future-debates-an-euforea-report
#3
W J Fokkens, C Bachert, M Bernal-Sprekelsen, J Bousquet, M Djandji, A Dorenbaum, D Hakimi-Mehr, S Hendry, C Hopkins, A Leunig, L Mannent, D Mucha, M Onerci, B Pugin, S Toppila-Salmi, P Rowe, S F Seys, S Stimson, A Strzembosz, P W Hellings
The first Rhinology Future Debates was held in Brussels in December 2016, organized by EUFOREA (European Forum for Research and Education in Allergy and Airways diseases). The purpose of these debates is to bring novel developments in the field of Rhinology to the attention of the medical, paramedical and patient community, in a highly credible and balanced context. For the first time in Rhinology, a peer to peer scientific exchange with key experts in the field of rhinology and key medical colleagues from leading industries let to a brainstorming and discussion event on a number of hot issues in Rhinology...
November 22, 2017: Rhinology
https://www.readbyqxmd.com/read/29166133/dosimetric-impact-of-gastrointestinal-air-column-in-radiation-treatment-of-pancreatic-cancer
#4
Neil C Estabrook, Jonathan B Corn, Marvene E Ewing, Higinia R Cardenes, Indra J Das
OBJECTIVE: Dosimetric evaluation of air column in gastro-intestinal (GI) structures in IMRT of pancreatic cancer. METHODS: Nine sequential patients were retrospectively chosen for dosimetric analysis of air column in the GI apparatus in pancreatic cancer using cone beam CT (CBCT). The 4DCT was used for target and organs at risk (OARs) and non-coplanar IMRT was used for treatment. Once/week, these patients underwent CBCT for air filling, isocenter verification and dose calculations retrospectively...
November 22, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/29165843/pillar-5-arenes-based-supramolecular-organic-framework-with-multi-guests-detection-and-recyclable-separation-properties
#5
Qi Lin, Yan-Qing Fan, Peng-Peng Mao, Lu Liu, Juan Liu, You-Ming Zhang, Hong Yao, Tai-Bao Wei
The selective detection and separation of target ions or molecules is an intriguing issue. Herein, a novel supramolecular organic framework (SOF-THBP) was constructed by bis-thioacetylhydrazine functionalized pillar[5]arenes. The SOF-THBP shows fluorescent response for Fe3+, Cr3+, Hg2+ and Cu2+. The xerogel of SOF-THBP shows excellent recyclable separation properties for these metal ions and the absorption rates were up to 99.29%. More interestingly, by rationally introduced these metal ions into the SOF-THBP, a series of metal ions coordinated SOFs (MSOFs) such as MSOF-Fe, MSOF-Hg and MSOF-Cu were constructed...
November 22, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29165700/epigenetic-therapy-novel-translational-implications-for-arrest-of-environmental-dioxin-induced-disease-in-females
#6
Zaraq Khan, Ye Zheng, Tiffanny L Jones, Abigail A Delaney, Luiz F Correa, Chandra C Shenoy, Khashayarsha Khazaie, Gaurang S Daftary
Increased toxicant exposure and resultant environmentally-induced diseases are a tradeoff of industrial productivity. Dioxin (TCDD: 2,3,7,8 tetrachlorodibenzo-p-dioxin), a ubiquitous by-product is associated with a spectrum of diseases including endometriosis, a common, chronic disease in women. TCDD activates cytochrome p450 (CYP) metabolic enzymes, which alters organ function to cause disease. In contrast, the transcription factor, Krüppel-Like Factor (KLF) 11 represses these enzymes via epigenetic mechanisms...
November 17, 2017: Endocrinology
https://www.readbyqxmd.com/read/29165683/systematic-review-occupational-illness-in-the-waste-and-recycling-sector
#7
C J M Poole, S Basu
Background: The waste and recycling sector is a growing part of industry. Whether health surveillance is indicated and how it should be undertaken is unclear. Aims: To undertake a review of the literature to identify hazards to health, biological effects and occupational illnesses for workers in the sector. Methods: A systematic review of the published literature and two UK databases. Results: Rates of fatal, non-fatal injuries and self-reported work-related illness were found to be higher in the waste and recycling sector than in UK industry as a whole...
November 20, 2017: Occupational Medicine
https://www.readbyqxmd.com/read/29165619/comparison-of-response-of-passive-dosimetry-systems-in-scanning-proton-radiotherapy-a-study-using-paediatric-anthropomorphic-phantoms
#8
Ž Kneževic, I Ambrozova, C Domingo, M De Saint-Hubert, M Majer, I Martínez-Rovira, S Miljanic, N Mojzeszek, P Porwol, O Ploc, M Romero-Expósito, L Stolarczyk, S Trinkl, R M Harrison, P Olko
Proton beam therapy has advantages in comparison to conventional photon radiotherapy due to the physical properties of proton beams (e.g. sharp distal fall off, adjustable range and modulation). In proton therapy, there is the possibility of sparing healthy tissue close to the target volume. This is especially important when tumours are located next to critical organs and while treating cancer in paediatric patients. On the other hand, the interactions of protons with matter result in the production of secondary radiation, mostly neutrons and gamma radiation, which deposit their energy at a distance from the target...
November 18, 2017: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/29165491/fe3o4-aunps-anchored-2d-metal-organic-framework-nanosheets-with-dna-regulated-switchable-peroxidase-like-activity
#9
Bing Tan, Huimin Zhao, Weihao Wu, Xuan Liu, Yaobin Zhang, Xie Quan
Two-dimensional (2D) metal-organic framework (MOF) nanosheets emerging as a new member of the 2D family have received significant research interest in recent years. Herein, we have successfully synthesized 2D copper-based MOF nanosheets with bimetallic anchorage using a facile two-step process at room temperature and ambient pressure, denoted as Cu(HBTC)-1/Fe3O4-AuNPs nanosheets. The as-synthesized 2D bimetallic MOF nanosheets displayed enhanced peroxidase-like activity with relatively high catalytic velocity and affinity for substrates compared with previously reported peroxidase mimics...
November 22, 2017: Nanoscale
https://www.readbyqxmd.com/read/29165248/neuromodulatory-connectivity-defines-the-structure-of-a-behavioral-neural-network
#10
Feici Diao, Amicia D Elliott, Fengqiu Diao, Sarav Shah, Benjamin H White
Neural networks are typically defined by their synaptic connectivity, yet synaptic wiring diagrams often provide limited insight into network function. This is due partly to the importance of non-synaptic communication by neuromodulators, which can dynamically reconfigure circuit activity to alter its output. Here we systematically map the patterns of neuromodulatory connectivity in a network that governs a developmentally critical behavioral sequence in Drosophila. This sequence, which mediates pupal ecdysis, is governed by the serial release of several key factors, which act both somatically as hormones and within the brain as neuromodulators...
November 22, 2017: ELife
https://www.readbyqxmd.com/read/29165100/phytochemicals-formulated-as-nanoparticles-inventions-recent-patents-and-future-prospects
#11
Namdeo Jadhav, Sameer Nadaf, Dipali Lohar, Pravin Ghagare, Trupti Powar
BACKGROUND: The quest to improve the therapeutic effectiveness of herbal drugs has driven rigorously the pharmaceutical research towards development of herbal nanoparticles. Till date, various approaches have been adopted for the design of herbal nanoparticles. METHODS: We carried out an organized search of bibliographic databases consisting of an ample number of published abstracts and research articles using a focused review questionaries and insertion/omission criteria...
November 19, 2017: Recent Patents on Drug Delivery & Formulation
https://www.readbyqxmd.com/read/29165073/recent-progress-in-delivery-of-therapeutic-and-imaging-agents-utilizing-organic-inorganic-hybrid-nanoparticles
#12
Haque Sheikh Tanzina, Ezharul Chowdhury
Delivery of conventional small molecule drugs and currently evolving nucleic acid-based therapeutics, such as small interfering RNAs (siRNAs) and genes, and contrast agents for high resolution imaging, to the target site of action is highly demanding to increase the therapeutic and imaging efficacy while minimizing the off-target effects of the delivered molecules, as well as develop novel therapeutic and imaging approaches. Organic-inorganic hybrid nanoparticles offer a number of advantages by combining the unique properties of the organic and inorganic counterparts, thus improving the pharmacokinetic behavior and targetability of drugs and contrast agents, and conferring the exclusive optical and magnetic properties for both therapeutic and imaging purposes...
November 19, 2017: Current Drug Delivery
https://www.readbyqxmd.com/read/29165062/recent-progress-of-crosslinking-strategies-for-polymeric-micelles-with-enhanced-drug-delivery-in-cancer-therapy
#13
Wei Fan, Luye Zhang, Yiwen Li, Haoxing Wu
The drug delivery by versatile types of self-assembled micelles for tumor treatment, which improved the diagnostic and therapeutic effectiveness, is advocated. However, despite the numerous advantages, applications of most micelle system have been retarded by low in vivo bio-stability which led to premature drug release and nonspecific tissue accumulation. To date, a range of chemistries has been introduced in intermolecular non-covalent/covalent crosslinking strategies for these dynamic nanostructures to produce robust functional nanoparticles with enhanced circulation stability and lower non-targeted organ toxicity...
November 20, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/29164989/shining-a-light-examining-similarities-and-differences-in-the-work-psychology-of-health-support-workers-employed-in-long-term-care-and-home-and-community-care-settings
#14
Tyrone A Perreira, Whitney Berta, Audrey Laporte, Liane Ginsburg, Raisa Deber, Gillian Elliott, Janet Lum
Health Support Workers (HSWs) provide up to 80% of care to residents and clients in the long-term care (LTC) and home and community care (HCC) sectors but have received little research attention compared with the regulated professions. The authors explore similarities and differences in the work psychology of HSWs employed in LTC and HCC settings. Data were collected via survey from 276 LTC and 184 HCC HSWs. Descriptive statistics and path analyses were conducted. HSWs in LTC and HCC settings have significant, positive associations between organizational citizenship behaviors directed toward the organization (OCB-Os) and psychological empowerment, as well as intention to stay (ITS) and job satisfaction...
November 1, 2017: Journal of Applied Gerontology: the Official Journal of the Southern Gerontological Society
https://www.readbyqxmd.com/read/29164940/applying-ecological-frameworks-in-obesity-intervention-studies-in-hispanic-latino-youth-a-systematic-review
#15
Carmen Kiraly, Melanie T Turk, Melissa A Kalarchian, Cheryl Shaffer
INTRODUCTION: In the United States, Hispanic children have higher rates of obesity compared with non-Hispanic White children. An ecological framework provides a holistic view of the environment to which Hispanic/Latino children are exposed that can potentially inform prevention and treatment initiatives for this vulnerable population. METHOD: This systematic review examines the existing evidence on the use of an ecological framework in intervention studies targeting overweight and obesity in Hispanic youth from birth to 8 years...
September 2017: Hispanic Health Care International: the Official Journal of the National Association of Hispanic Nurses
https://www.readbyqxmd.com/read/29164924/towards-enhanced-pet-quantification-in-clinical-oncology
#16
Habib Zaidi, Nicolas Karakatsanis
Positron emission tomography (PET) has, since its inception, established itself as the imaging modality of choice for the in vivo quantitative assessment of molecular targets in a wide range of biochemical processes underlying tumour physiology. PET image quantification enables to ascertain a direct link between the time-varying activity concentration in organs/tissues and the fundamental parameters portraying the biological processes at the cellular level being assessed. However, the quantitative potential of PET may be affected by a number of factors related to physical effects, hardware and software system specifications, tracer kinetics, motion, scan protocol design and limitations in current image-derived PET metrics...
November 22, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/29164876/live-cell-imaging-of-endogenous-rnas-using-pumilio-homology-domain-mutants-principles-and-applications
#17
Hideaki Yoshimura
Recently, dynamic changes in RNA location in space and time in living cells have become a target of interest in biology because of their essential roles in controlling physiological phenomena. To visualize RNA, methods for the fluorescence labeling of RNA in living cells have been developed. For RNA labeling, oligonucleotide-based RNA probes have mainly been used because of their high selectivity for target RNAs. By contrast, protein-based RNA probes have not been used widely because of their lack of design flexibility, although they have various potential advantages compared with nucleotide-based probes, such as controllability of intracellular localization, high detectability, and ease of introduction to cells and transgenic organisms in cell type and tissue specific manner by genetic engineering techniques...
November 22, 2017: Biochemistry
https://www.readbyqxmd.com/read/29164873/plasma-protein-turnover-rates-in-rats-using-stable-isotope-labeling-global-proteomics-and-activity-based-protein-profiling
#18
Jordan Ned Smith, Kimberly J Tyrrell, Joshua R Hansen, Dennis George Thomas, Taylor A Murphree, Anil K Shukla, Teresa Luders, James M Madden, YunYing Li, Aaron T Wright, Paul D Piehowski
Protein turnover is important for general health on cellular and organism scales providing a strategy to replace old, damaged, or dysfunctional proteins. Protein turnover also informs of biomarker kinetics, as a better understanding of synthesis and degradation of proteins increases the clinical utility of biomarkers. Here, turnover rates of plasma proteins in rats were measured in vivo using a pulse-chase stable isotope labeling experiment. During the pulse, rats (n=5) were fed 13C6-labeled lysine ("heavy") feed for 23 days to label proteins...
November 22, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/29164849/an-emulsion-hydrogel-soft-motor-actuated-by-thermal-stimulation
#19
Hui Wang, Yuling Liang, Wei Gao, Renfeng Dong, Chaoyang Wang
An emulsion hydrogel motor (E-H-motor) constituted by low-boiling oil fuel and hydrogel matrix, is prepared through a simple yet versatile oil-in-water (O/W) emulsion template method. The E-H-motor can be efficiently propelled by the bubbles generated under thermal stimulus. As thermal-inducted explosion occurs inside the E-H-motor (diameter ~4.0 mm, length ~6.0 mm), the gas bubbles resulting from thermotropic phase transition are violently ejected from one side, leading to a fast speed of 14.78 ± 4.82 mm s-1 in a 60 oC aqueous solution...
November 22, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29164609/who-benefits-from-adolescent-sleep-interventions-moderators-of-treatment-efficacy-in-a-randomized-controlled-trial-of-a-cognitive-behavioral-and-mindfulness-based-group-sleep-intervention-for-at-risk-adolescents
#20
Matthew J Blake, Laura M Blake, Orli Schwartz, Monika Raniti, Joanna M Waloszek, Greg Murray, Julian G Simmons, Elizabeth Landau, Ronald E Dahl, Dana L McMakin, Paul Dudgeon, John Trinder, Nicholas B Allen
BACKGROUND: The aim of this study was to test moderators of therapeutic improvement in an adolescent cognitive-behavioral and mindfulness-based group sleep intervention. Specifically, we examined whether the effects of the program on postintervention sleep outcomes were dependent on participant gender and/or measures of sleep duration, anxiety, depression, and self-efficacy prior to the interventions. METHOD: Secondary analysis of a randomized controlled trial conducted with 123 adolescent participants (female = 59...
November 22, 2017: Journal of Child Psychology and Psychiatry, and Allied Disciplines
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