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https://www.readbyqxmd.com/read/28098899/analysis-of-gene-expression-profiles-of-non-small-cell-lung-cancer-at-different-stages-reveals-significantly-altered-biological-functions-and-candidate-genes
#1
Jin Wang, Jianxiang Song, Zhengya Gao, Xudong Huo, Yajun Zhang, Wencai Wang, Jianwei Qi, Shiying Zheng
We attempt to dissect the pathology of non-small cell lung cancer (NSCLC) patients at different stages and discover the novel candidate genes. Microarray data (GSE21933) were retrieved from the Gene Expression Omnibus database. The differential expression profiles of lung tumor tissues during different stages were analyzed. The significantly altered functions and pathways were assessed and the key nodes in a protein-protein interaction (PPI) network were screened out. Then, the coexpression gene pairs and tumor-related genes were assessed...
January 17, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28098880/the-role-of-gap-junctions-in-inflammatory-and-neoplastic-disorders-review
#2
Pui Wong, Victoria Laxton, Saurabh Srivastava, Yin Wah Fiona Chan, Gary Tse
Gap junctions are intercellular channels made of connexin proteins, mediating both electrical and biochemical signals between cells. The ability of gap junction proteins to regulate immune responses, cell proliferation, migration, apoptosis and carcinogenesis makes them attractive therapeutic targets for treating inflammatory and neoplastic disorders in different organ systems. Alterations in gap junction profile and expression levels are observed in hyperproliferative skin disorders, lymphatic vessel diseases, inflammatory lung diseases, liver injury and neoplastic disorders...
January 17, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28098817/spatial-analysis-of-human-health-risk-due-to-arsenic-exposure-through-drinking-groundwater-in-taiwan-s-pingtung-plain
#3
Ching-Ping Liang, Yi-Chi Chien, Cheng-Shin Jang, Ching-Fang Chen, Jui-Sheng Chen
Chronic arsenic (As) exposure continues to be a public health problem of major concern worldwide, affecting hundreds of millions of people. A long-term groundwater quality survey has revealed that 20% of the groundwater in southern Taiwan's Pingtung Plain is clearly contaminated with a measured As concentration in excess of the maximum level of 10 µg/L recommended by the World Health Organization. The situation is further complicated by the fact that more than half of the inhabitants in this area continue to use groundwater for drinking...
January 14, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28098761/pancreatic-neuroendocrine-neoplasms-basic-biology-current-treatment-strategies-and-prospects-for-the-future
#4
REVIEW
Akihiro Ohmoto, Hirofumi Rokutan, Shinichi Yachida
Pancreatic neuroendocrine neoplasms (pNENs) are rare tumors accounting for only 1%-2% of all pancreatic tumors. pNENs are pathologically heterogeneous and are categorized into three groups (neuroendocrine tumor: NET G1, NET G2; and neuroendocrine carcinoma: NEC) on the basis of the Ki-67 proliferation index and the mitotic count according to the 2010 World Health Organization (WHO) classification of gastroenteropancreatic NENs. NEC in this classification includes both histologically well-differentiated and poorly differentiated subtypes, and modification of the WHO 2010 classification is under discussion based on genetic and clinical data...
January 13, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28097883/is-angiotensin-3-4-val-tyr-the-shortest-angiotensin-ii-derived-peptide-opening-new-vistas-on-the-renin-angiotensin-system
#5
Juliana Dias, Flavia Axelband, Lucienne S Lara, Humberto Muzi-Filho, Adalberto Vieyra
Angiotensin-(3-4) (Ang-(3-4) or Val-Tyr) is the shorter angiotensin (Ang) II-derived peptide, formed through successive hydrolysis that culminates with the release of Val-Tyr as a dipeptide. It is formed both in plasma and in kidney from Ang II and Ang III, and can be considered a component of the systemic and organ-based renin-angiotensin system. It is potently antihypertensive in humans and rats, and its concerted actions on proximal tubule cells culminate in the inhibition of fluid reabsorption, hyperosmotic urinary excretion of Na(+)...
January 2017: Journal of the Renin-angiotensin-aldosterone System: JRAAS
https://www.readbyqxmd.com/read/28097785/down-regulation-of-bnda1-whose-gene-locus-is-associated-with-the-seeds-weight-improves-the-seeds-weight-and-organ-size-in-brassica-napus
#6
Jie-Li Wang, Min-Qiang Tang, Sheng Chen, Xiang-Feng Zheng, Hui-Xian Mo, Sheng-Jun Li, Zheng Wang, Ke-Ming Zhu, Li-Na Ding, Sheng-Yi Liu, Yun-Hai Li, Xiao-Li Tan
Brassica napus L. is an important oil crop worldwide, and is the main raw material for biofuel. Seed weight and seed size are the main contributors to seed yield. DA1 (DA means big in Chinese) is an ubiquitin receptor and negatively regulates seed size. Down-regulation of AtDA1 in Arabidopsis leads to larger seeds and organs by increasing cell proliferation in integuments. In this study, BnDA1was down-regulated in B. napus by over expressed of AtDA1(R358K) , which is a functional deficiency of DA1 with an arginine-to-lysine mutation at the 358(th) amino acid...
January 17, 2017: Plant Biotechnology Journal
https://www.readbyqxmd.com/read/28097647/microbiota-composition-and-pulmonary-surfactant-protein-expression-as-markers-of-death-by-drowning
#7
So-Yeon Lee, Seung-Kyun Woo, So-Min Lee, Eun-Ju Ha, Kyoung-Hee Lim, Kyung-Hwa Choi, Young-Hee Roh, Yong-Bin Eom
Pathological diagnosis of drowning remains a challenge for forensic science, because of a lack of pathognomonic findings. We analyzed microbiota and surfactant protein in the lungs for a novel diagnosis of drowning. All rats were divided into drowning, postmortem submersion, and control groups. The water, lungs, closed organs (kidney and liver), and cardiac blood in rats were assayed by targeting 16S ribosomal RNA of Miseq sequencing. Lung samples were analyzed by immunohistochemical staining for surfactant protein A...
January 18, 2017: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/28097538/the-role-of-glutamine-synthetase-in-energy-production-and-glutamine-metabolism-during-oxidative-stress
#8
Nohaiah Aldarini, Azhar A Alhasawi, Sean C Thomas, Vasu D Appanna
Oxidative stress is known to severely impede aerobic adenosine triphosphate (ATP) synthesis. However, the metabolically-versatile Pseudomonas fluorescens survives this challenge by invoking alternative ATP-generating networks. When grown in a medium with glutamine as the sole organic nutrient in the presence of H2O2, the microbe utilizes glutamine synthetase (GS) to modulate its energy budget. The activity of this enzyme that mediates the release of energy stored in glutamine was sharply increased in the stressed cells compared to the controls...
January 17, 2017: Antonie Van Leeuwenhoek
https://www.readbyqxmd.com/read/28097512/deletion-of-nlrp3-protects-from-inflammation-induced-skeletal-muscle-atrophy
#9
Nora Huang, Melanie Kny, Fabian Riediger, Katharina Busch, Sibylle Schmidt, Friedrich C Luft, Hortense Slevogt, Jens Fielitz
BACKGROUND: Critically ill patients develop atrophic muscle failure, which increases morbidity and mortality. Interleukin-1β (IL-1β) is activated early in sepsis. Whether IL-1β acts directly on muscle cells and whether its inhibition prevents atrophy is unknown. We aimed to investigate if IL-1β activation via the Nlrp3 inflammasome is involved in inflammation-induced atrophy. METHODS: We performed an experimental study and prospective animal trial. The effect of IL-1β on differentiated C2C12 muscle cells was investigated by analyzing gene-and-protein expression, and atrophy response...
December 2017: Intensive Care Medicine Experimental
https://www.readbyqxmd.com/read/28097368/incidence-of-and-risk-factors-for-skin-cancer-in-organ-transplant-recipients-in-the-united-states
#10
Giorgia L Garrett, Paul D Blanc, John Boscardin, Amanda Abramson Lloyd, Rehana L Ahmed, Tiffany Anthony, Kristin Bibee, Andrew Breithaupt, Jennifer Cannon, Amy Chen, Joyce Y Cheng, Zelma Chiesa-Fuxench, Oscar R Colegio, Clara Curiel-Lewandrowski, Christina A Del Guzzo, Max Disse, Margaret Dowd, Robert Eilers, Arisa Elena Ortiz, Caroline Morris, Spring K Golden, Michael S Graves, John R Griffin, R Samuel Hopkins, Conway C Huang, Gordon Hyeonjin Bae, Anokhi Jambusaria, Thomas A Jennings, Shang I Brian Jiang, Pritesh S Karia, Shilpi Khetarpal, Changhyun Kim, Goran Klintmalm, Kathryn Konicke, Shlomo A Koyfman, Charlene Lam, Peter Lee, Justin J Leitenberger, Tiffany Loh, Stefan Lowenstein, Reshmi Madankumar, Jacqueline F Moreau, Rajiv I Nijhawan, Shari Ochoa, Edit B Olasz, Elaine Otchere, Clark Otley, Jeremy Oulton, Parth H Patel, Vishal Anil Patel, Arpan V Prabhu, Melissa Pugliano-Mauro, Chrysalyne D Schmults, Sarah Schram, Allen F Shih, Thuzar Shin, Seaver Soon, Teresa Soriano, Divya Srivastava, Jennifer A Stein, Kara Sternhell-Blackwell, Stan Taylor, Allison Vidimos, Peggy Wu, Nicholas Zajdel, Daniel Zelac, Sarah T Arron
Importance: Skin cancer is the most common malignancy occurring after organ transplantation. Although previous research has reported an increased risk of skin cancer in solid organ transplant recipients (OTRs), no study has estimated the posttransplant population-based incidence in the United States. Objective: To determine the incidence and evaluate the risk factors for posttransplant skin cancer, including squamous cell carcinoma (SCC), melanoma (MM), and Merkel cell carcinoma (MCC) in a cohort of US OTRs receiving a primary organ transplant in 2003 or 2008...
January 11, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/28097070/sponge-exhalent-seawater-contains-a-unique-chemical-profile-of-dissolved-organic-matter
#11
Cara L Fiore, Christopher J Freeman, Elizabeth B Kujawinski
Sponges are efficient filter feeders, removing significant portions of particulate and dissolved organic matter (POM, DOM) from the water column. While the assimilation and respiration of POM and DOM by sponges and their abundant microbial symbiont communities have received much attention, there is virtually no information on the impact of sponge holobiont metabolism on the composition of DOM at a molecular-level. We applied untargeted and targeted metabolomics techniques to characterize DOM in seawater samples prior to entering the sponge (inhalant reef water), in samples exiting the sponge (exhalent seawater), and in samples collected just outside the reef area (off reef seawater)...
2017: PeerJ
https://www.readbyqxmd.com/read/28096902/functional-characterization-of-the-active-mutator-like-transposable-element-muta1-from-the-mosquito-aedes-aegypti
#12
Kun Liu, Susan R Wessler
BACKGROUND: Mutator-like transposable elements (MULEs) are widespread with members in fungi, plants, and animals. Most of the research on the MULE superfamily has focused on plant MULEs where they were discovered and where some are extremely active and have significant impact on genome structure. The maize MuDR element has been widely used as a tool for both forward and reverse genetic studies because of its high transposition rate and preference for targeting genic regions. However, despite being widespread, only a few active MULEs have been identified, and only one, the rice Os3378, has demonstrated activity in a non-host organism...
2017: Mobile DNA
https://www.readbyqxmd.com/read/28096721/current-concepts-in-non-gastrointestinal-stromal-tumor-soft-tissue-sarcomas-a-primer-for-radiologists
#13
REVIEW
Akshay D Baheti, Jyothi P Jagannathan, Ailbhe O'Neill, Harika Tirumani, Sree Harsha Tirumani
Non-gastrointestinal stromal tumor (GIST) soft tissue sarcomas (STSs) are a heterogeneous group of neoplasms whose classification and management continues to evolve with better understanding of their biologic behavior. The 2013 World Health Organization (WHO) has revised their classification based on new immunohistochemical and cytogenetic data. In this article, we will provide a brief overview of the revised WHO classification of soft tissue tumors, discuss in detail the radiology and management of the two most common adult non-GIST STS, namely liposarcoma and leiomyosarcoma, and review some of the emerging histology-driven targeted therapies in non-GIST STS, focusing on the role of the radiologist...
January 2017: Korean Journal of Radiology: Official Journal of the Korean Radiological Society
https://www.readbyqxmd.com/read/28096698/burkitt-lymphoma-in-adolescents-and-young-adults-management-challenges
#14
REVIEW
Massimo Dozzo, Francesca Carobolante, Pietro Maria Donisi, Annamaria Scattolin, Elena Maino, Rosaria Sancetta, Piera Viero, Renato Bassan
About one-half of all Burkitt lymphoma (BL) patients are younger than 40 years, and one-third belong to the adolescent and young adult (AYA) subset, defined by an age between 15 and 25-40 years, based on selection criteria used in different reports. BL is an aggressive B-cell neoplasm displaying highly characteristic clinico-diagnostic features, the biologic hallmark of which is a translocation involving immunoglobulin and c-MYC genes. It presents as sporadic, endemic, or epidemic disease. Endemicity is pathogenetically linked to an imbalance of the immune system which occurs in African children infected by malaria parasites and Epstein-Barr virus, while the epidemic form strictly follows the pattern of infection by HIV...
2017: Adolescent Health, Medicine and Therapeutics
https://www.readbyqxmd.com/read/28096670/lung-targeting-drug-delivery-system-of-baicalin-loaded-nanoliposomes-development-biodistribution-in-rabbits-and-pharmacodynamics-in-nude-mice-bearing-orthotopic-human-lung-cancer
#15
Yumeng Wei, Jing Liang, Xiaoli Zheng, Chao Pi, Hao Liu, Hongru Yang, Yonggen Zou, Yun Ye, Ling Zhao
The present study aims to develop a kind of novel nanoliposomes for the lung-targeting delivery system of baicalin as a Chinese medicine monomer. Baicalin-loaded nanoliposomes were prepared by the effervescent dispersion and lyophilized techniques. Baicalin-loaded nanoliposomes had an average particle size of 131.7±11.7 nm with 0.19±0.02 polydispersity index, 82.8%±1.24% entrapment efficiency and 90.47%±0.93% of yield and sustaining drug release effect over 24 h and were stable for 12 months at least. In vitro no hemolytic activity was observed for the experimental drug concentration...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28096487/a-clostridium-difficile-specific-gel-forming-protein-required-for-optimal-spore-germination
#16
M Lauren Donnelly, William Li, Yong-Qing Li, Lauren Hinkel, Peter Setlow, Aimee Shen
: Clostridium difficile is a Gram-positive spore-forming obligate anaerobe that is a leading cause of antibiotic-associated diarrhea worldwide. In order for C. difficile to initiate infection, its aerotolerant spore form must germinate in the gut of mammalian hosts. While almost all spore-forming organisms use transmembrane germinant receptors to trigger germination, C. difficile uses the pseudoprotease CspC to sense bile salt germinants. CspC activates the related subtilisin-like protease CspB, which then proteolytically activates the cortex hydrolase SleC...
January 17, 2017: MBio
https://www.readbyqxmd.com/read/28096404/torc1-dependent-sumoylation-of-rpc82-promotes-rna-polymerase-iii-assembly-and-activity
#17
Pierre Chymkowitch, Aurélie Nguéa P, Håvard Aanes, Joseph Robertson, Arne Klungland, Jorrit M Enserink
Maintaining cellular homeostasis under changing nutrient conditions is essential for the growth and development of all organisms. The mechanisms that maintain homeostasis upon loss of nutrient supply are not well understood. By mapping the SUMO proteome in Saccharomyces cerevisiae, we discovered a specific set of differentially sumoylated proteins mainly involved in transcription. RNA polymerase III (RNAPIII) components, including Rpc53, Rpc82, and Ret1, are particularly prominent nutrient-dependent SUMO targets...
January 17, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28096292/regulation-of-kidney-development-by-the-mdm2-mdm4-p53-axis
#18
REVIEW
Samir El-Dahr, Sylvia Hilliard, Zubaida Saifudeen
While p53 activity is required for tumor suppression, unconstrained p53 activity on the other hand is detrimental to the organism, resulting in inappropriate cellular death or proliferation defects. Unimpeded p53 activity is lethal in the developing embryo, underlining the need for maintaining a tight control on p53 activity during this period. The critical role of the negative regulators of p53, Mdm2 and Mdm4, in vertebrate development came to light by fatal disruption of embryogenesis that was observed with Mdm2 and Mdm4 gene deletions in mice...
January 17, 2017: Journal of Molecular Cell Biology
https://www.readbyqxmd.com/read/28096196/craniospinal-irradiation-using-helical-tomotherapy-for-central-nervous-system-tumors
#19
Sanziana R I Schiopu, Gregor Habl, Matthias Häfner, Sonja Katayama, Klaus Herfarth, Juergen Debus, Florian Sterzing
The aim of this study was to describe early and late toxicity, survival and local control in 45 patients with primary brain tumors treated with helical tomotherapy craniospinal irradiation (HT-CSI). From 2006 to 2014, 45 patients with central nervous system malignancies were treated with HT-CSI. The most common tumors were medulloblastoma in 20 patients, ependymoma in 10 patients, intracranial germinoma (ICG) in 7 patients, and primitive neuroectodermal tumor in 4 patients. Hematological toxicity during treatment included leukopenia Grades 1-4 (6...
January 17, 2017: Journal of Radiation Research
https://www.readbyqxmd.com/read/28096092/initiation-of-acute-graft-versus-host-disease-by-angiogenesis
#20
Katarina Riesner, Yu Shi, Angela Jacobi, Martin Kraeter, Martina Kalupa, Aleixandria McGearey, Sarah Mertlitz, Steffen Cordes, Jens-Florian Schrezenmeier, Jörg Mengwasser, Sabine Westphal, Daniel Perez-Hernandez, Clemens Schmitt, Gunnar Dittmar, Jochen Guck, Olaf Penack
The inhibition of inflammation-associated angiogenesis ameliorates inflammatory diseases by reducing the recruitment of tissue infiltrating leukocytes. However, it is not known if angiogenesis has an active role during the initiation of inflammation or if it is merely a secondary effect occurring in response to stimuli by tissue infiltrating leukocytes. Here we show that angiogenesis precedes leukocyte infiltration in experimental models of inflammatory bowel disease and acute graft-versus-host disease (GVHD)...
January 17, 2017: Blood
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