Sheema Khan, Saini Setua, Sonam Kumari, Nirnoy Dan, Andrew Massey, Bilal Bin Hafeez, Murali M Yallapu, Zachary Edwar Stiles, Anas Alabkaa, Junming Yue, Aditya Ganju, Stephen Behrman, Meena Jaggi, Subhash C Chauhan
Pancreatic cancer is a complex disease accounting for fibrotic tumors and an aggressive phenotype. Gemcitabine (GEM) is used as a standard therapy, which develops chemoresistance leading to poor patient outcome. We have recently developed a superparamagnetic iron oxide nanoparticle (SPION) formulation of curcumin (SP-CUR), which is a nontoxic, bioactive anti-inflammatory/anti-cancer agent for its enhanced delivery in tumors. In this study, we demonstrate that SP-CUR effectively delivers bioactive curcumin to pancreatic tumors, simultaneously enhances GEM uptake and its efficacy...
July 2019: Biomaterials