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Hyluronic acid

Alireza Zakeri, Mohammad Javad Rasaee, Navid Pourzardosht
Hyaluronic acid (HA) is a high molecular weight linear polysaccharide, endowed with unique physiological and biological properties. Given its unique properties, HA have unprecedented applications in the fields of medicine and cosmetics. The ever growing demand for HA production is the driving force behind the need for finding and developing novel and amenable sources of the HA producers. Microbial fermentation of Streptococcus zooepidemicus deemed as one the most expeditious and pervasive methods of HA production...
December 2017: Biotechnology Reports
Feng Xia, Shuguang Wang, Min Chen, Xiaojun Wang, Xiaobin Feng, Jiahong Dong
PURPOSE: The purpose of the study is to evaluate the protective effects of Verapamil on hepatic ischemia-reperfusion injury in cirrhotic patients with HCC. METHOD: A controlled study was performed on 86 consecutive patients with cirrhosis who underwent liver resection for suffering HCC. Thirty-nine patients were injected with Verapamil through the mesenteric vein before Pringle's maneuver to alleviate hepatic ischemia-reperfusion injury, while 47 patients were not...
November 2009: Langenbeck's Archives of Surgery
Vera Regina Rodrigues Camacho, Themis Reverbel da Silveira, Jarbas Rodrigues de Oliveira, Sérgio Gabriel Silva de Barros, Carlos Thadeu Schmidt Cerski
BACKGROUND: Serologic markers have been proposed for monitoring hepatic fibrosis in chronic liver disease. Among fibrosis markers, type III procollagen (PIIIP) and hyaluronic acid have been studied in these patients. AIM: To evaluate the association between these serum markers with histological findings. METHODS: A prospective cross-sectional study was carried out with HCV-positive blood donors. The studied population included men and women whose age ranged from 18 to 60 years, with elevated liver function tests [ALT levels > 1...
April 2007: Arquivos de Gastroenterologia
Eiji Shimpuku, Kazutoshi Hamada, Akiyoshi Handa, Kunihiko Kobayashi, Tomotaka Nakajima, Hitoshi Yamazaki, Masato Nakamura, Hiroaki Fukuda, Joji Mochida
Hyluronic acid (HA) on tissue healing has been controversial. We examined the molecular pharmacology of HA injection at the suture site in an acute model of supracoracoid tendon laceration using chickens, an injury of a nonweight-bearing joint considered similar to the human shoulder. Expression of mRNAs encoding alpha I (I) and alphaI (III) procollagens was localized using in situ hybridization (ISH). Intensities of mRNA expression for alpha I (I) and alpha I (III) procollagens, transforming growth factor-beta1 (TGF- beta1), basic fibroblast growth factor (bFGF), and insulin-like growth factor (IGF) were determined by quantitative reverse transcription-polymerase chain reaction (RT-PCR)...
February 2007: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
Huazhong Li, Kenji Morimoto, Tetsuya Kimura, Kazuo Sakka, Kunio Ohmiya
A beta-N-acetylglucosaminidase gene (nag84A) was cloned from Clostridium paraputrificum M-21 in Escherichia coli. The nag84A gene consists of an open reading frame of 4647 by encoding 1549 amino acids, with a deduced molecular weight of 174,311, which have a catalytic domain belonging to family 84 of the glycoside hydrolases. Nag84A was purified from a recombinant E. coli and characterized. Although Nag84A exhibited high homology to the hyaluronidase from Clostridium perfringens, it did not degrade hyluronic acid...
2003: Journal of Bioscience and Bioengineering
W M Tian, C L Zhang, S P Hou, X Yu, F Z Cui, Q Y Xu, S L Sheng, H Cui, H D Li
Nogo-66 and NgR are important receptors inhibiting neuronal regeneration and therefore are targets for treating CNS injury. Antagonists of this receptor including blocking antibodies are potential therapeutic agents for CNS axonal injuries such as spinal cord and brain trauma. A new antibody (IgG) releasing system has been developed by covalently attaching IgG to the biodegradable hyaluronic acid (HA) hydrogel via the hydrolytically unstable hydrazone linkage, aiming to deliver the antibody of CNS regeneration inhibitors to the injured brain...
January 20, 2005: Journal of Controlled Release: Official Journal of the Controlled Release Society
U Wollina, T Karamfilov
Pyoderma gangrenosum sometimes takes a recalcitrant course that is unresponsive to standard immuno-suppression with corticosteroids and/or cyclosporin A. In these cases improvement of painful ulcerations is a therapeutic challenge. We report a 17-year-old boy with severe pyoderma gangrenosum treated successfully with mycophenolate mofetil and autologous keratinocyte transplantation using an esterified hyluronic acid delivery system.
May 2000: Journal of the European Academy of Dermatology and Venereology: JEADV
D H Manicourt, J C Pita, E J Thonar, D S Howell
Proteoglycans were extracted and purified without dissociation (a-A1 preparations) from superficial and deeper layers of high weight-bearing (HWA) and low weight-bearing (LWA) areas of dog normal articular cartilage. These proteoglycans were then characterized by velocity gradient centrifugation. In each of the 4 different topographical regions, the weight average sedimentation coefficients related strongly with total hexuronate content of the tissue. In the superficial layers, almost all aggregates had low sedimentation coefficients: the aggregates were smaller and less abundant in LWA than in HWA...
1991: Connective Tissue Research
M McCabe, T C Laurent
A method is reported for the measurement of the diffusion coefficients in water of some sparingly soluble gases. The results obtained for the diffusion coefficients of oxygen and nitrogen gas through water at 25 degrees C are 2.12. 10-5 and 2.61 . 10-5 cm-2 . s-1, respectively. A check on the accuracy of the teachnique using tritiated water as the diffusing substance gave a value of 2.15 . 10-5 cm-2 . s-1 which agrees within 3% with recent values from the literature. The method was applied to the measurement of oxygen, nitrogen, and tritiated water diffusion coefficients through agarose gels and through agarose gels containing hyluronate...
July 14, 1975: Biochimica et Biophysica Acta
R Varma, R S Varma, W S Allen, A H Wardi
Paper chromatography of neutral sugars and gas chromatography of their aldononitrile acetates indicated the presence of fucose, arabinose and a small amount of glucose in purified human umbilical cord hyaluronate. The molar ratios of serine, threonine and aspartic acid to neutral sugars were not unity, suggesting the non-involvement of the neutral sugars and the amino acids in a carbohydrate-protein linkage. The same was indicated by an increase in the percentage of the aforementioned amino acids and by the absence of sugar alditols in umbilical cord hyaluronate reduced eith NaBH4 -PdCl2, after alkali treatment...
July 14, 1975: Biochimica et Biophysica Acta
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